TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 20
Active chains: 6
Family: TYR
Uniprot: FGFR3_HUMAN
Kinase Domain Residues: 472 - 750
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 12 60.0% 9D1XA
DFGin BLAminus 7 35.0% AF-P22607-K1A
DFGin BLBplus 1 5.0% 8UDUA

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
4K33A 459 755 806.0 ACP:801 ATPlike Active DFGin 6.252 13.787 BLAminus -133.88, -173.58 58.49, 82.81 -96.43, 27.55 291.81, 80.95 -59.32, -31.32 in-in in 8.211 Saltbr-in 2.895 HRD-in -87.09, -47.34 67.06, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.89, 133.11 APE9-dihe-in -125.43, 130.21 APE8-dihe-in -78.76, 72.58 APE8-rot-na 29.71 APE67-dihe-in -71.45, -4.47 -50.14, -48.75 APE12-dist-na 13.31 APE11-dist-na 9.602 APE10-dist-na 8.305 APE9-dist-in 6.873 C482A,C582S,K650E None None XRAY 2.341 0.181 0.228 A 325 293 4 0 0 0 [[472, 750]] 1.0 4k33 TYR_FGFR3_HUMAN TYR 2.3e-104 354.2 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
AF-P22607-K1A 464 758 806.0 No_ligand No_ligand Active DFGin 6.562 13.72 BLAminus -135.6, -172.84 54.36, 70.3 -87.69, 11.11 291.08, 95.72 -59.35, -30.65 in-in in 7.439 Saltbr-in 2.65 HRD-in -71.1, -43.09 66.59, -18.9 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.08, 128.6 APE9-dihe-in -136.51, 151.31 APE8-dihe-in -81.26, 77.84 APE8-rot-na 37.52 APE67-dihe-in -66.67, -14.17 -46.27, -41.56 APE12-dist-na 14.39 APE11-dist-na 9.904 APE10-dist-na 9.996 APE9-dist-in 6.521 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[472, 750]] 1.0 AF-P22607-K1 TYR_FGFR3_HUMAN TYR 1.6e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
AF-P22607-K3A 464 758 806.0 No_ligand No_ligand Active DFGin 6.362 13.763 BLAminus -140.11, -178.74 60.69, 64.92 -81.11, 10.08 291.09, 95.14 -60.2, -27.32 in-in in 7.694 Saltbr-in 2.724 HRD-in -81.64, -44.23 60.23, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.46, 141.09 APE9-dihe-in -143.98, 144.08 APE8-dihe-in -81.78, 61.47 APE8-rot-na 36.97 APE67-dihe-in -68.61, -8.42 -45.34, -43.48 APE12-dist-na 14.454 APE11-dist-na 10.934 APE10-dist-na 10.364 APE9-dist-in 6.946 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[472, 750]] 1.0 AF-P22607-K3 TYR_FGFR3_HUMAN TYR 1.6e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
6LVMA 472 755 806.0 EVR:60801 Type1.5_Back Active DFGin 6.528 14.251 BLAminus -141.75, -180.0 67.67, 74.35 -89.33, 29.0 297.0, 117.38 -56.22, -44.89 in-in in 7.87 Saltbr-in 3.304 HRD-in -81.99, -57.17 74.69, 3.13 in-in-in SNCiii in-in ActLoopNT-in 3.023 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.44, 126.31 APE9-dihe-in -128.79, 145.49 APE8-dihe-in -85.23, 77.25 APE8-rot-na 30.53 APE67-dihe-in -75.5, -6.21 -67.03, -34.23 APE12-dist-na 14.131 APE11-dist-na 10.493 APE10-dist-na 10.62 APE9-dist-in 6.82 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.53 0.211 0.279 A 313 276 8 0 0 0 [[472, 750]] 1.0 6lvm TYR_FGFR3_HUMAN TYR 2e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
7DHLA 472 755 806.0 H6X:60801 Type1.5_Back Active DFGin 5.905 13.891 BLAminus -128.75, 172.71 75.89, 84.08 -98.64, 30.77 301.65, 163.04 -59.86, -43.17 in-in in 7.804 Saltbr-in 3.205 HRD-in -74.83, -62.31 81.14, 3.67 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.21, 114.53 APE9-dihe-in -123.29, 143.17 APE8-dihe-in -76.55, 75.16 APE8-rot-na 29.19 APE67-dihe-in -80.84, -3.09 -66.95, -32.19 APE12-dist-na 14.415 APE11-dist-na 10.488 APE10-dist-na 10.067 APE9-dist-in 6.821 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.57 0.197 0.254 A 313 277 7 0 0 0 [[472, 750]] 1.0 7dhl TYR_FGFR3_HUMAN TYR 2e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDUB 459 755 806.0 WIQ:61002 Type1.5_Front Active DFGin 6.421 14.415 BLAminus -138.69, 176.26 64.2, 86.01 -100.28, 24.84 287.71, 79.66 -57.6, -41.09 in-in in 8.185 Saltbr-in 2.946 HRD-in -71.69, -47.92 71.62, 0.22 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 155.75 APE9-dihe-in -122.51, 89.95 APE8-dihe-in -81.37, 70.05 APE8-rot-na 30.61 APE67-dihe-in -66.22, -12.9 -45.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 7.661 APE10-dist-na 8.489 APE9-dist-in 7.717 P572S,P573G None None XRAY 1.737 0.231 0.256 B 297 276 9 0 0 1 [[472, 750]] 1.0 8udu TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9KFUA 448 756 806.0 A1L5T:801 Type1 Inactive DFGin 7.019 14.492 BLAminus -131.22, -178.97 62.43, 68.96 -89.65, 16.94 287.35, 89.22 -61.48, -27.48 in-in in 7.689 Saltbr-in 2.766 HRD-in -73.03, -51.34 76.73, -9.72 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.53, 13.75 APE9-dihe-in -98.46, 127.45 APE8-dihe-in -57.08, 120.6 APE8-rot-na 333.93 APE67-dihe-in -72.45, -11.1 -67.2, -26.43 APE12-dist-na 9.97 APE11-dist-na 10.764 APE10-dist-na 7.042 APE9-dist-in 4.799 None None None XRAY 1.4 0.229 0.251 A 309 288 21 0 0 6 [[472, 750]] 1.0 9kfu TYR_FGFR3_HUMAN TYR 1.7e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
6PNXA 456 757 806.0 ACP:801 ATPlike Inactive DFGin 5.183 13.257 BLAplus -117.43, 165.96 59.53, 36.21 -90.35, -22.61 56.49, 88.29 -100.71, 20.75 in-out in 7.758 Saltbr-out 3.892 HRD-in -72.74, -43.96 72.66, -12.59 out-out-out SNCooo out-out ActLoopNT-out 8.611 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 61.32, -168.18 APE9-dihe-in -95.45, 138.6 APE8-dihe-in -83.08, 62.92 APE8-rot-na 32.84 APE67-dihe-in -77.59, -4.01 -63.19, -31.79 APE12-dist-na 17.76 APE11-dist-na 14.387 APE10-dist-na 16.475 APE9-dist-in 7.98 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 A 324 291 11 0 0 0 [[472, 750]] 1.0 6pnx TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
6PNXB 455 756 806.0 ACP:801 ATPlike Inactive DFGin 5.102 12.88 BLAplus -116.22, 163.18 57.59, 45.48 -96.33, -11.84 56.51, 88.18 -107.89, 22.55 in-in in 7.372 Saltbr-in 2.381 HRD-in -94.02, -38.66 69.29, -17.12 in-out-out SNCioo out-out ActLoopNT-out 4.149 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 54.33, 74.29 APE9-dihe-in -157.39, 146.53 APE8-dihe-in -79.85, 92.16 APE8-rot-na 29.38 APE67-dihe-in -64.97, -14.94 -62.55, -40.44 APE12-dist-na 17.529 APE11-dist-na 16.958 APE10-dist-na 14.632 APE9-dist-in 7.491 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 B 324 294 8 0 0 0 [[472, 750]] 1.0 6pnx TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDTA 457 756 806.0 MLT:61001,MLT:61002,WGF:61003 Allosteric,Allosteric,Type1.5_Front Inactive DFGin 5.441 13.493 BLAplus -114.8, 158.79 55.69, 43.2 -82.19, -34.37 42.84, 89.08 -83.27, -4.41 in-out in 8.383 Saltbr-out 5.287 HRD-in -68.34, -46.54 75.89, -9.4 out-out-out SNCooo out-out ActLoopNT-out 7.921 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.29 APE8-dihe-out -63.06, -32.23 APE8-rot-na 340.92 APE67-dihe-in -68.35, -26.42 -62.13, -28.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.198 P572S,P573G None None XRAY 2.829 0.263 0.274 A 297 284 4 0 0 4 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9D1XA 461 754 806.0 A1A6M:2001 Type1 Inactive DFGin 5.12 12.632 BLAplus -108.03, 159.86 61.02, 36.65 -81.76, -20.43 56.47, 81.47 -95.6, 7.99 in-in in 7.873 Saltbr-in 3.088 HRD-in -69.72, -49.85 77.77, -9.05 in-out-out SNCioo out-out ActLoopNT-out 7.414 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -149.56, 157.12 APE9-dihe-in -112.69, 98.2 APE8-dihe-out -58.57, -23.42 APE8-rot-na 337.44 APE67-dihe-in -70.39, -9.82 -57.35, -25.35 APE12-dist-na 16.005 APE11-dist-na 20.086 APE10-dist-na 17.503 APE9-dist-out 11.305 P572S,P573G None None XRAY 1.6 0.18 0.19 A 297 282 0 0 0 0 [[472, 750]] 1.0 9d1x TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9CD7A 451 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.019 12.728 BLAplus -114.49, 161.16 51.06, 50.03 -90.62, -20.91 50.11, 84.08 -82.82, 141.47 in-in in 7.095 Saltbr-in 2.583 HRD-in -75.51, -51.62 85.64, -15.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 85.15 APE8-dihe-out -64.87, -3.22 APE8-rot-na 28.88 APE67-dihe-in -77.21, -9.06 -69.64, -25.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.346 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 A 312 276 29 0 0 17 [[472, 750]] 1.0 9cd7 TYR_FGFR3_HUMAN TYR 2e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9CD7B 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.065 12.859 BLAplus -114.57, 159.12 51.43, 51.5 -92.22, -19.36 49.89, 84.09 -76.73, -39.85 in-in in 7.413 Saltbr-in 2.597 HRD-in -74.94, -51.38 85.94, -16.13 in-out-out SNCioo out-out ActLoopNT-out 7.599 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.12 APE8-dihe-out -65.12, -2.8 APE8-rot-na 29.36 APE67-dihe-in -77.72, -8.63 -66.93, -28.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.217 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 B 312 278 20 0 0 6 [[472, 750]] 1.0 9cd7 TYR_FGFR3_HUMAN TYR 2e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9CD7C 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.055 12.917 BLAplus -113.11, 157.29 52.27, 52.26 -91.9, -19.06 50.44, 84.08 -76.91, -39.15 in-in in 7.421 Saltbr-in 2.602 HRD-in -75.28, -51.41 85.96, -15.25 in-out-out SNCioo out-out ActLoopNT-out 7.712 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.75 APE8-dihe-out -72.0, 23.1 APE8-rot-na 34.26 APE67-dihe-in -76.94, -9.16 -66.89, -26.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.796 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 C 312 278 20 0 0 6 [[472, 750]] 1.0 9cd7 TYR_FGFR3_HUMAN TYR 2e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDVA 458 755 806.0 WIQ:1003 Type1.5_Back Inactive DFGin 6.001 13.476 BLAplus -124.26, 161.29 66.5, 36.68 -91.33, -43.75 46.96, 90.73 -84.73, 13.25 in-in in 7.661 Saltbr-in 2.94 HRD-in -66.26, -46.33 75.0, -11.55 in-out-out SNCioo out-out ActLoopNT-out 8.16 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -144.63, 151.27 APE9-dihe-in -107.88, 92.32 APE8-dihe-out -54.6, -21.22 APE8-rot-na 338.66 APE67-dihe-in -68.84, -8.83 -57.22, -29.15 APE12-dist-na 15.956 APE11-dist-na 19.998 APE10-dist-na 17.285 APE9-dist-out 11.612 V555M None None XRAY 2.348 0.237 0.261 A 297 279 7 0 0 7 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDVB 455 755 806.0 WIQ:803 Type1.5_Back Inactive DFGin 5.481 13.254 BLAplus -124.6, 164.38 63.05, 27.71 -82.13, -38.21 55.85, 89.15 -91.32, 13.57 in-in in 7.68 Saltbr-in 2.904 HRD-in -63.59, -46.44 79.4, -13.95 in-out-out SNCioo out-out ActLoopNT-out 8.907 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -136.87, 152.88 APE9-dihe-in -110.79, 96.93 APE8-dihe-out -58.89, -20.81 APE8-rot-na 338.74 APE67-dihe-in -70.46, -8.74 -52.69, -32.19 APE12-dist-na 15.479 APE11-dist-na 19.386 APE10-dist-na 16.703 APE9-dist-out 11.424 V555M None None XRAY 2.348 0.237 0.261 B 297 281 8 0 0 8 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDVC 458 755 806.0 WIQ:1004 Type1.5_Back Inactive DFGin 6.071 13.431 BLAplus -124.65, 164.21 70.39, 38.16 -109.8, -21.91 57.41, 87.59 -78.9, -34.05 in-in in 7.655 Saltbr-in 2.888 HRD-in -64.72, -49.48 77.07, -10.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 91.25 APE8-dihe-out -54.32, -20.59 APE8-rot-na 338.75 APE67-dihe-in -71.87, -8.91 -59.36, -26.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.626 V555M None None XRAY 2.348 0.237 0.261 C 297 269 17 0 0 16 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDTB 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.71 BLAplus -108.64, 157.87 56.15, 40.62 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.445 Saltbr-out 5.398 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.867 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.666 APE9-dist-out 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297 283 3 0 0 3 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDTC 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.824 BLAplus -109.74, 157.08 55.91, 40.67 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.103 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.87 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.405 APE9-dist-out 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297 284 4 0 0 4 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDUA 460 756 806.0 WIQ:61002 Type1.5_Back Inactive DFGin 5.761 13.529 BLBplus -121.3, 171.32 71.72, 21.7 -99.77, 166.76 66.11, 93.34 95.58, -59.45 in-in in 7.917 Saltbr-in 2.734 HRD-in -77.2, -48.45 77.61, -12.83 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.65, 162.44 APE9-dihe-in -54.1, 129.25 APE8-dihe-in -83.64, 61.19 APE8-rot-na 34.62 APE67-dihe-in -73.43, -8.03 -52.16, -35.97 APE12-dist-na 999.0 APE11-dist-na 14.232 APE10-dist-na 17.747 APE9-dist-out 8.253 P572S,P573G None None XRAY 1.737 0.231 0.256 A 297 277 8 0 0 8 [[472, 750]] 1.0 8udu TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3

TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 20
Active chains: 6
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 12 60.0% 9D1XA
DFGin BLAminus 7 35.0% AF-P22607-K1A
DFGin BLBplus 1 5.0% 8UDUA

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FGFR3_HUMAN 4K33A P22607 459 755 806.0 ACP:801 ATPlike Active DFGin 6.252 13.787 BLAminus -133.88, -173.58 58.49, 82.81 -96.43, 27.55 291.81, 80.95 -59.32, -31.32 in-in in 8.211 Saltbr-in 2.895 HRD-in -87.09, -47.34 67.06, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.89, 133.11 APE9-dihe-in -125.43, 130.21 APE8-dihe-in -78.76, 72.58 APE8-rot-na 29.71 APE67-dihe-in -71.45, -4.47 -50.14, -48.75 APE12-dist-na 13.31 APE11-dist-na 9.602 APE10-dist-na 8.305 APE9-dist-in 6.873 C482A,C582S,K650E None None XRAY 2.341 0.181 0.228 A 325 293 4 0 0 0 [[472, 750]] 1.0 4k33 Homo sapiens TYR_FGFR3_HUMAN TYR 2.3e-104 354.2 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN AF-P22607-K1A P22607 464 758 806.0 No_ligand No_ligand Active DFGin 6.562 13.72 BLAminus -135.6, -172.84 54.36, 70.3 -87.69, 11.11 291.08, 95.72 -59.35, -30.65 in-in in 7.439 Saltbr-in 2.65 HRD-in -71.1, -43.09 66.59, -18.9 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.08, 128.6 APE9-dihe-in -136.51, 151.31 APE8-dihe-in -81.26, 77.84 APE8-rot-na 37.52 APE67-dihe-in -66.67, -14.17 -46.27, -41.56 APE12-dist-na 14.39 APE11-dist-na 9.904 APE10-dist-na 9.996 APE9-dist-in 6.521 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[472, 750]] 1.0 AF-P22607-K1 Homo sapiens TYR_FGFR3_HUMAN TYR 1.6e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN AF-P22607-K3A P22607 464 758 806.0 No_ligand No_ligand Active DFGin 6.362 13.763 BLAminus -140.11, -178.74 60.69, 64.92 -81.11, 10.08 291.09, 95.14 -60.2, -27.32 in-in in 7.694 Saltbr-in 2.724 HRD-in -81.64, -44.23 60.23, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.46, 141.09 APE9-dihe-in -143.98, 144.08 APE8-dihe-in -81.78, 61.47 APE8-rot-na 36.97 APE67-dihe-in -68.61, -8.42 -45.34, -43.48 APE12-dist-na 14.454 APE11-dist-na 10.934 APE10-dist-na 10.364 APE9-dist-in 6.946 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[472, 750]] 1.0 AF-P22607-K3 Homo sapiens TYR_FGFR3_HUMAN TYR 1.6e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 6LVMA P22607 472 755 806.0 EVR:60801 Type1.5_Back Active DFGin 6.528 14.251 BLAminus -141.75, -180.0 67.67, 74.35 -89.33, 29.0 297.0, 117.38 -56.22, -44.89 in-in in 7.87 Saltbr-in 3.304 HRD-in -81.99, -57.17 74.69, 3.13 in-in-in SNCiii in-in ActLoopNT-in 3.023 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.44, 126.31 APE9-dihe-in -128.79, 145.49 APE8-dihe-in -85.23, 77.25 APE8-rot-na 30.53 APE67-dihe-in -75.5, -6.21 -67.03, -34.23 APE12-dist-na 14.131 APE11-dist-na 10.493 APE10-dist-na 10.62 APE9-dist-in 6.82 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.53 0.211 0.279 A 313 276 8 0 0 0 [[472, 750]] 1.0 6lvm Homo sapiens TYR_FGFR3_HUMAN TYR 2e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 7DHLA P22607 472 755 806.0 H6X:60801 Type1.5_Back Active DFGin 5.905 13.891 BLAminus -128.75, 172.71 75.89, 84.08 -98.64, 30.77 301.65, 163.04 -59.86, -43.17 in-in in 7.804 Saltbr-in 3.205 HRD-in -74.83, -62.31 81.14, 3.67 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.21, 114.53 APE9-dihe-in -123.29, 143.17 APE8-dihe-in -76.55, 75.16 APE8-rot-na 29.19 APE67-dihe-in -80.84, -3.09 -66.95, -32.19 APE12-dist-na 14.415 APE11-dist-na 10.488 APE10-dist-na 10.067 APE9-dist-in 6.821 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.57 0.197 0.254 A 313 277 7 0 0 0 [[472, 750]] 1.0 7dhl Homo sapiens TYR_FGFR3_HUMAN TYR 2e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDUB P22607 459 755 806.0 WIQ:61002 Type1.5_Front Active DFGin 6.421 14.415 BLAminus -138.69, 176.26 64.2, 86.01 -100.28, 24.84 287.71, 79.66 -57.6, -41.09 in-in in 8.185 Saltbr-in 2.946 HRD-in -71.69, -47.92 71.62, 0.22 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 155.75 APE9-dihe-in -122.51, 89.95 APE8-dihe-in -81.37, 70.05 APE8-rot-na 30.61 APE67-dihe-in -66.22, -12.9 -45.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 7.661 APE10-dist-na 8.489 APE9-dist-in 7.717 P572S,P573G None None XRAY 1.737 0.231 0.256 B 297 276 9 0 0 1 [[472, 750]] 1.0 8udu Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9KFUA P22607 448 756 806.0 A1L5T:801 Type1 Inactive DFGin 7.019 14.492 BLAminus -131.22, -178.97 62.43, 68.96 -89.65, 16.94 287.35, 89.22 -61.48, -27.48 in-in in 7.689 Saltbr-in 2.766 HRD-in -73.03, -51.34 76.73, -9.72 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.53, 13.75 APE9-dihe-in -98.46, 127.45 APE8-dihe-in -57.08, 120.6 APE8-rot-na 333.93 APE67-dihe-in -72.45, -11.1 -67.2, -26.43 APE12-dist-na 9.97 APE11-dist-na 10.764 APE10-dist-na 7.042 APE9-dist-in 4.799 None None None XRAY 1.4 0.229 0.251 A 309 288 21 0 0 6 [[472, 750]] 1.0 9kfu Homo sapiens TYR_FGFR3_HUMAN TYR 1.7e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 6PNXA P22607 456 757 806.0 ACP:801 ATPlike Inactive DFGin 5.183 13.257 BLAplus -117.43, 165.96 59.53, 36.21 -90.35, -22.61 56.49, 88.29 -100.71, 20.75 in-out in 7.758 Saltbr-out 3.892 HRD-in -72.74, -43.96 72.66, -12.59 out-out-out SNCooo out-out ActLoopNT-out 8.611 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 61.32, -168.18 APE9-dihe-in -95.45, 138.6 APE8-dihe-in -83.08, 62.92 APE8-rot-na 32.84 APE67-dihe-in -77.59, -4.01 -63.19, -31.79 APE12-dist-na 17.76 APE11-dist-na 14.387 APE10-dist-na 16.475 APE9-dist-in 7.98 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 A 324 291 11 0 0 0 [[472, 750]] 1.0 6pnx Homo sapiens TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 6PNXB P22607 455 756 806.0 ACP:801 ATPlike Inactive DFGin 5.102 12.88 BLAplus -116.22, 163.18 57.59, 45.48 -96.33, -11.84 56.51, 88.18 -107.89, 22.55 in-in in 7.372 Saltbr-in 2.381 HRD-in -94.02, -38.66 69.29, -17.12 in-out-out SNCioo out-out ActLoopNT-out 4.149 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 54.33, 74.29 APE9-dihe-in -157.39, 146.53 APE8-dihe-in -79.85, 92.16 APE8-rot-na 29.38 APE67-dihe-in -64.97, -14.94 -62.55, -40.44 APE12-dist-na 17.529 APE11-dist-na 16.958 APE10-dist-na 14.632 APE9-dist-in 7.491 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 B 324 294 8 0 0 0 [[472, 750]] 1.0 6pnx Homo sapiens TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDTA P22607 457 756 806.0 MLT:61001,MLT:61002,WGF:61003 Allosteric,Allosteric,Type1.5_Front Inactive DFGin 5.441 13.493 BLAplus -114.8, 158.79 55.69, 43.2 -82.19, -34.37 42.84, 89.08 -83.27, -4.41 in-out in 8.383 Saltbr-out 5.287 HRD-in -68.34, -46.54 75.89, -9.4 out-out-out SNCooo out-out ActLoopNT-out 7.921 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.29 APE8-dihe-out -63.06, -32.23 APE8-rot-na 340.92 APE67-dihe-in -68.35, -26.42 -62.13, -28.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.198 P572S,P573G None None XRAY 2.829 0.263 0.274 A 297 284 4 0 0 4 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9D1XA P22607 461 754 806.0 A1A6M:2001 Type1 Inactive DFGin 5.12 12.632 BLAplus -108.03, 159.86 61.02, 36.65 -81.76, -20.43 56.47, 81.47 -95.6, 7.99 in-in in 7.873 Saltbr-in 3.088 HRD-in -69.72, -49.85 77.77, -9.05 in-out-out SNCioo out-out ActLoopNT-out 7.414 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -149.56, 157.12 APE9-dihe-in -112.69, 98.2 APE8-dihe-out -58.57, -23.42 APE8-rot-na 337.44 APE67-dihe-in -70.39, -9.82 -57.35, -25.35 APE12-dist-na 16.005 APE11-dist-na 20.086 APE10-dist-na 17.503 APE9-dist-out 11.305 P572S,P573G None None XRAY 1.6 0.18 0.19 A 297 282 0 0 0 0 [[472, 750]] 1.0 9d1x Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9CD7A P22607 451 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.019 12.728 BLAplus -114.49, 161.16 51.06, 50.03 -90.62, -20.91 50.11, 84.08 -82.82, 141.47 in-in in 7.095 Saltbr-in 2.583 HRD-in -75.51, -51.62 85.64, -15.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 85.15 APE8-dihe-out -64.87, -3.22 APE8-rot-na 28.88 APE67-dihe-in -77.21, -9.06 -69.64, -25.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.346 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 A 312 276 29 0 0 17 [[472, 750]] 1.0 9cd7 Homo sapiens TYR_FGFR3_HUMAN TYR 2e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9CD7B P22607 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.065 12.859 BLAplus -114.57, 159.12 51.43, 51.5 -92.22, -19.36 49.89, 84.09 -76.73, -39.85 in-in in 7.413 Saltbr-in 2.597 HRD-in -74.94, -51.38 85.94, -16.13 in-out-out SNCioo out-out ActLoopNT-out 7.599 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.12 APE8-dihe-out -65.12, -2.8 APE8-rot-na 29.36 APE67-dihe-in -77.72, -8.63 -66.93, -28.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.217 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 B 312 278 20 0 0 6 [[472, 750]] 1.0 9cd7 Homo sapiens TYR_FGFR3_HUMAN TYR 2e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9CD7C P22607 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.055 12.917 BLAplus -113.11, 157.29 52.27, 52.26 -91.9, -19.06 50.44, 84.08 -76.91, -39.15 in-in in 7.421 Saltbr-in 2.602 HRD-in -75.28, -51.41 85.96, -15.25 in-out-out SNCioo out-out ActLoopNT-out 7.712 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.75 APE8-dihe-out -72.0, 23.1 APE8-rot-na 34.26 APE67-dihe-in -76.94, -9.16 -66.89, -26.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.796 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 C 312 278 20 0 0 6 [[472, 750]] 1.0 9cd7 Homo sapiens TYR_FGFR3_HUMAN TYR 2e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDVA P22607 458 755 806.0 WIQ:1003 Type1.5_Back Inactive DFGin 6.001 13.476 BLAplus -124.26, 161.29 66.5, 36.68 -91.33, -43.75 46.96, 90.73 -84.73, 13.25 in-in in 7.661 Saltbr-in 2.94 HRD-in -66.26, -46.33 75.0, -11.55 in-out-out SNCioo out-out ActLoopNT-out 8.16 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -144.63, 151.27 APE9-dihe-in -107.88, 92.32 APE8-dihe-out -54.6, -21.22 APE8-rot-na 338.66 APE67-dihe-in -68.84, -8.83 -57.22, -29.15 APE12-dist-na 15.956 APE11-dist-na 19.998 APE10-dist-na 17.285 APE9-dist-out 11.612 V555M None None XRAY 2.348 0.237 0.261 A 297 279 7 0 0 7 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDVB P22607 455 755 806.0 WIQ:803 Type1.5_Back Inactive DFGin 5.481 13.254 BLAplus -124.6, 164.38 63.05, 27.71 -82.13, -38.21 55.85, 89.15 -91.32, 13.57 in-in in 7.68 Saltbr-in 2.904 HRD-in -63.59, -46.44 79.4, -13.95 in-out-out SNCioo out-out ActLoopNT-out 8.907 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -136.87, 152.88 APE9-dihe-in -110.79, 96.93 APE8-dihe-out -58.89, -20.81 APE8-rot-na 338.74 APE67-dihe-in -70.46, -8.74 -52.69, -32.19 APE12-dist-na 15.479 APE11-dist-na 19.386 APE10-dist-na 16.703 APE9-dist-out 11.424 V555M None None XRAY 2.348 0.237 0.261 B 297 281 8 0 0 8 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDVC P22607 458 755 806.0 WIQ:1004 Type1.5_Back Inactive DFGin 6.071 13.431 BLAplus -124.65, 164.21 70.39, 38.16 -109.8, -21.91 57.41, 87.59 -78.9, -34.05 in-in in 7.655 Saltbr-in 2.888 HRD-in -64.72, -49.48 77.07, -10.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 91.25 APE8-dihe-out -54.32, -20.59 APE8-rot-na 338.75 APE67-dihe-in -71.87, -8.91 -59.36, -26.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.626 V555M None None XRAY 2.348 0.237 0.261 C 297 269 17 0 0 16 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDTB P22607 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.71 BLAplus -108.64, 157.87 56.15, 40.62 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.445 Saltbr-out 5.398 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.867 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.666 APE9-dist-out 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297 283 3 0 0 3 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDTC P22607 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.824 BLAplus -109.74, 157.08 55.91, 40.67 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.103 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.87 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.405 APE9-dist-out 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297 284 4 0 0 4 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDUA P22607 460 756 806.0 WIQ:61002 Type1.5_Back Inactive DFGin 5.761 13.529 BLBplus -121.3, 171.32 71.72, 21.7 -99.77, 166.76 66.11, 93.34 95.58, -59.45 in-in in 7.917 Saltbr-in 2.734 HRD-in -77.2, -48.45 77.61, -12.83 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.65, 162.44 APE9-dihe-in -54.1, 129.25 APE8-dihe-in -83.64, 61.19 APE8-rot-na 34.62 APE67-dihe-in -73.43, -8.03 -52.16, -35.97 APE12-dist-na 999.0 APE11-dist-na 14.232 APE10-dist-na 17.747 APE9-dist-out 8.253 P572S,P573G None None XRAY 1.737 0.231 0.256 A 297 277 8 0 0 8 [[472, 750]] 1.0 8udu Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3

TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name