TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 28
Active chains: 6
Family: TYR
Uniprot: FGFR3_HUMAN
Kinase Domain Residues: 472 - 750
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 20 71.4% 9D1XA
DFGin BLAminus 7 25.0% AF-P22607-K1A
DFGin BLBplus 1 3.6% 8UDUA

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
4K33A 459 755 806.0 ACP:801 ATPlike Active DFGin 6.252 13.787 BLAminus DFGAsp-rot-in -133.88, -173.58 58.49, 82.81 197.25, -16.95 -96.43, 27.55 291.81, 80.95 -59.32, -31.32 in-in in 8.211 Saltbr-in 2.895 HRD-in -87.09, -47.34 67.06, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -55.89, 133.11 APE9-dihe-in -125.43, 130.21 APE8-dihe-in -78.76, 72.58 APE8-rot-na 29.71 APE67-dihe-in -71.45, -4.47 -50.14, -48.75 APE12-dist-na 13.31 APE11-dist-na 9.602 APE10-dist-na 8.305 APE9-dist-na 6.873 C482A,C582S,K650E None None XRAY 2.341 0.181 0.228 A 325 293 4 0 0 0 [[472, 750]] 1.0 4k33 TYR_FGFR3_HUMAN TYR 2.4e-104 354.2 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
AF-P22607-K1A 464 758 806.0 No_ligand No_ligand Active DFGin 6.562 13.72 BLAminus DFGAsp-rot-in -135.6, -172.84 54.36, 70.3 200.96, 24.32 -87.69, 11.11 291.08, 95.72 -59.35, -30.65 in-in in 7.439 Saltbr-in 2.65 HRD-in -71.1, -43.09 66.59, -18.9 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -62.08, 128.6 APE9-dihe-in -136.51, 151.31 APE8-dihe-in -81.26, 77.84 APE8-rot-na 37.52 APE67-dihe-in -66.67, -14.17 -46.27, -41.56 APE12-dist-na 14.39 APE11-dist-na 9.904 APE10-dist-na 9.996 APE9-dist-na 6.521 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[472, 750]] 1.0 AF-P22607-K1 TYR_FGFR3_HUMAN TYR 1.7e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
AF-P22607-K3A 464 758 806.0 No_ligand No_ligand Active DFGin 6.362 13.763 BLAminus DFGAsp-rot-in -140.11, -178.74 60.69, 64.92 205.01, 9.05 -81.11, 10.08 291.09, 95.14 -60.2, -27.32 in-in in 7.694 Saltbr-in 2.724 HRD-in -81.64, -44.23 60.23, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -64.46, 141.09 APE9-dihe-in -143.98, 144.08 APE8-dihe-in -81.78, 61.47 APE8-rot-na 36.97 APE67-dihe-in -68.61, -8.42 -45.34, -43.48 APE12-dist-na 14.454 APE11-dist-na 10.934 APE10-dist-na 10.364 APE9-dist-na 6.946 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[472, 750]] 1.0 AF-P22607-K3 TYR_FGFR3_HUMAN TYR 1.7e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
6LVMA 472 755 806.0 EVR:60801 Type1.5_Back Active DFGin 6.528 14.251 BLAminus DFGAsp-rot-in -141.75, -180.0 67.67, 74.35 212.38, -7.8 -89.33, 29.0 297.0, 117.38 -56.22, -44.89 in-in in 7.87 Saltbr-in 3.304 HRD-in -81.99, -57.17 74.69, 3.13 in-in-in SNCiii in-in ActLoopNT-in 3.023 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -86.44, 126.31 APE9-dihe-in -128.79, 145.49 APE8-dihe-in -85.23, 77.25 APE8-rot-na 30.53 APE67-dihe-in -75.5, -6.21 -67.03, -34.23 APE12-dist-na 14.131 APE11-dist-na 10.493 APE10-dist-na 10.62 APE9-dist-na 6.82 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.53 0.211 0.279 A 313 276 8 0 0 0 [[472, 750]] 1.0 6lvm TYR_FGFR3_HUMAN TYR 2.1e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
7DHLA 472 755 806.0 H6X:60801 Type1.5_Back Active DFGin 5.905 13.891 BLAminus DFGAsp-rot-in -128.75, 172.71 75.89, 84.08 214.6, -2.2 -98.64, 30.77 301.65, 163.04 -59.86, -43.17 in-in in 7.804 Saltbr-in 3.205 HRD-in -74.83, -62.31 81.14, 3.67 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -89.21, 114.53 APE9-dihe-in -123.29, 143.17 APE8-dihe-in -76.55, 75.16 APE8-rot-na 29.19 APE67-dihe-in -80.84, -3.09 -66.95, -32.19 APE12-dist-na 14.415 APE11-dist-na 10.488 APE10-dist-na 10.067 APE9-dist-na 6.821 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.57 0.197 0.254 A 313 277 7 0 0 0 [[472, 750]] 1.0 7dhl TYR_FGFR3_HUMAN TYR 2.1e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDUB 459 755 806.0 WIQ:61002 Type1.5_Front Active DFGin 6.421 14.415 BLAminus DFGAsp-rot-in -138.69, 176.26 64.2, 86.01 192.54, -15.43 -100.28, 24.84 287.71, 79.66 -57.6, -41.09 in-in in 8.185 Saltbr-in 2.946 HRD-in -71.69, -47.92 71.62, 0.22 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -67.88, 155.75 APE9-dihe-in -122.51, 89.95 APE8-dihe-in -81.37, 70.05 APE8-rot-na 30.61 APE67-dihe-in -66.22, -12.9 -45.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 7.661 APE10-dist-na 8.489 APE9-dist-na 7.717 P572S,P573G None None XRAY 1.737 0.231 0.256 B 297 276 9 0 0 1 [[472, 750]] 1.0 8udu TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9KFUA 448 756 806.0 A1L5T:801 Type1 Inactive DFGin 7.019 14.492 BLAminus DFGAsp-rot-out -131.22, -178.97 62.43, 68.96 282.46, 4.78 -89.65, 16.94 287.35, 89.22 -61.48, -27.48 in-in in 7.689 Saltbr-in 2.766 HRD-in -73.03, -51.34 76.73, -9.72 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -98.53, 13.75 APE9-dihe-in -98.46, 127.45 APE8-dihe-in -57.08, 120.6 APE8-rot-na 333.93 APE67-dihe-in -72.45, -11.1 -67.2, -26.43 APE12-dist-na 9.97 APE11-dist-na 10.764 APE10-dist-na 7.042 APE9-dist-na 4.799 None None None XRAY 1.4 0.229 0.251 A 309 288 21 0 0 6 [[472, 750]] 1.0 9kfu TYR_FGFR3_HUMAN TYR 1.8e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
6PNXA 456 757 806.0 ACP:801 ATPlike Inactive DFGin 5.183 13.257 BLAplus DFGAsp-rot-out -117.43, 165.96 59.53, 36.21 289.47, -0.22 -90.35, -22.61 56.49, 88.29 -100.71, 20.75 in-out in 7.758 Saltbr-out 3.892 HRD-in -72.74, -43.96 72.66, -12.59 out-out-out SNCooo out-out ActLoopNT-out 8.611 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out 61.32, -168.18 APE9-dihe-in -95.45, 138.6 APE8-dihe-in -83.08, 62.92 APE8-rot-na 32.84 APE67-dihe-in -77.59, -4.01 -63.19, -31.79 APE12-dist-na 17.76 APE11-dist-na 14.387 APE10-dist-na 16.475 APE9-dist-na 7.98 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 A 324 291 11 0 0 0 [[472, 750]] 1.0 6pnx TYR_FGFR3_HUMAN TYR 2.6e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
6PNXB 455 756 806.0 ACP:801 ATPlike Inactive DFGin 5.102 12.88 BLAplus DFGAsp-rot-out -116.22, 163.18 57.59, 45.48 292.51, -6.63 -96.33, -11.84 56.51, 88.18 -107.89, 22.55 in-in in 7.372 Saltbr-in 2.381 HRD-in -94.02, -38.66 69.29, -17.12 in-out-out SNCioo out-out ActLoopNT-out 4.149 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out 54.33, 74.29 APE9-dihe-in -157.39, 146.53 APE8-dihe-in -79.85, 92.16 APE8-rot-na 29.38 APE67-dihe-in -64.97, -14.94 -62.55, -40.44 APE12-dist-na 17.529 APE11-dist-na 16.958 APE10-dist-na 14.632 APE9-dist-na 7.491 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 B 324 294 8 0 0 0 [[472, 750]] 1.0 6pnx TYR_FGFR3_HUMAN TYR 2.6e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDTA 457 756 806.0 MLT:61001,MLT:61002,WGF:61003 Allosteric,Allosteric,Type1.5_Front Inactive DFGin 5.441 13.493 BLAplus DFGAsp-rot-out -114.8, 158.79 55.69, 43.2 295.67, -51.96 -82.19, -34.37 42.84, 89.08 -83.27, -4.41 in-out in 8.383 Saltbr-out 5.287 HRD-in -68.34, -46.54 75.89, -9.4 out-out-out SNCooo out-out ActLoopNT-out 7.921 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.29 APE8-dihe-out -63.06, -32.23 APE8-rot-na 340.92 APE67-dihe-in -68.35, -26.42 -62.13, -28.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.198 P572S,P573G None None XRAY 2.829 0.263 0.274 A 297 284 4 0 0 4 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9VM9A 456 756 806.0 A1ESW:801 Type1 Inactive DFGin 4.966 13.492 BLAplus DFGAsp-rot-out -119.2253, 164.0599 63.1421, 28.0452 298.4088, -20.5723 -80.6137, -19.722 58.8265, 88.3498 -89.4979, 3.838 in-in in 8.227 Saltbr-in 3.087 HRD-in -83.5015, -38.9421 67.609, -4.9778 in-out-out SNCioo out-out ActLoopNT-out 7.488 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -161.4206, 160.008 APE9-dihe-in -107.118, 107.4877 APE8-dihe-out -62.9034, -10.7817 APE8-rot-na 339.842 APE67-dihe-in -73.7411, -10.7298 -67.7033, -23.1684 APE12-dist-na 16.035 APE11-dist-na 20.242 APE10-dist-na 18.306 APE9-dist-na 11.034 None None None XRAY 2.65 0.262 0.312 A 292 287 2 0 0 0 [[472, 750]] 1.0 9vm9 TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9VM9B 457 755 806.0 A1ESW:801 Type1 Inactive DFGin 4.897 13.418 BLAplus DFGAsp-rot-out -118.1146, 165.3887 61.3627, 30.6061 300.2288, -39.0485 -82.5158, -20.0989 61.779, 89.971 -89.4214, 0.2931 in-out in 8.194 Saltbr-out 4.343 HRD-in -78.6959, -44.4486 76.8665, -18.6531 out-out-out SNCooo out-out ActLoopNT-out 7.085 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -164.1861, 155.5897 APE9-dihe-in -100.8219, 112.393 APE8-dihe-out -62.6805, -15.6899 APE8-rot-na 338.614 APE67-dihe-in -73.9513, -16.6434 -66.7504, -20.5086 APE12-dist-na 15.925 APE11-dist-na 20.12 APE10-dist-na 18.159 APE9-dist-na 10.971 None None None XRAY 2.65 0.262 0.312 B 292 285 2 0 0 0 [[472, 750]] 1.0 9vm9 TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9VM9C 462 756 806.0 A1ESW:801 Type1 Inactive DFGin 4.981 13.216 BLAplus DFGAsp-rot-out -117.2651, 166.7429 62.5729, 25.3486 294.8151, -23.2774 -78.3678, -24.8213 55.9088, 91.3153 -86.7896, 3.5439 in-out in 8.16 Saltbr-out 4.018 HRD-in -78.4924, -39.3464 68.6842, -7.6966 out-out-out SNCooo out-out ActLoopNT-out 7.457 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -158.0344, 156.8491 APE9-dihe-in -101.6007, 111.3298 APE8-dihe-out -63.9614, -13.0871 APE8-rot-na 340.3288 APE67-dihe-in -75.3695, -10.2261 -66.4686, -23.6326 APE12-dist-na 15.991 APE11-dist-na 20.237 APE10-dist-na 18.228 APE9-dist-na 11.099 None None None XRAY 2.65 0.262 0.312 C 292 281 2 0 0 0 [[472, 750]] 1.0 9vm9 TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9VM9D 459 756 806.0 A1ESW:802 Type1 Inactive DFGin 5.041 13.235 BLAplus DFGAsp-rot-out -113.9306, 165.2223 61.6624, 22.0486 298.8167, -19.0768 -73.4743, -22.6442 57.5347, 87.6331 -90.2727, 1.583 in-none in 8.154 Saltbr-none 999.0 HRD-in -71.1771, -50.6322 76.5196, -3.1321 none-out-out SNCnoo out-out ActLoopNT-out 7.536 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -152.0562, 156.2583 APE9-dihe-in -103.8127, 110.8616 APE8-dihe-out -64.3171, -15.4813 APE8-rot-na 338.7707 APE67-dihe-in -74.9476, -13.3888 -65.6453, -22.3392 APE12-dist-na 15.838 APE11-dist-na 20.012 APE10-dist-na 17.941 APE9-dist-na 10.904 None None None XRAY 2.65 0.262 0.312 D 292 284 2 0 0 0 [[472, 750]] 1.0 9vm9 TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9VMBA 456 756 806.0 A1ESX:801 Type1 Inactive DFGin 4.993 13.461 BLAplus DFGAsp-rot-out -106.5175, 161.6879 65.3472, 18.46 293.7428, -21.3049 -70.1659, -20.2448 57.7617, 91.439 -90.0125, 3.5321 in-in in 8.114 Saltbr-in 3.154 HRD-in -73.0442, -49.8537 77.8647, -11.6549 in-out-out SNCioo out-out ActLoopNT-out 7.526 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -152.7604, 163.4923 APE9-dihe-in -109.8641, 99.2708 APE8-dihe-out -57.3812, -21.1375 APE8-rot-na 333.2281 APE67-dihe-in -72.5898, -10.0313 -56.6744, -26.6672 APE12-dist-na 15.764 APE11-dist-na 19.999 APE10-dist-na 18.055 APE9-dist-na 11.148 None None None XRAY 1.97 0.19 0.237 A 292 287 2 0 0 0 [[472, 750]] 1.0 9vmb TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9VMBB 456 756 806.0 A1ESX:801 Type1 Inactive DFGin 4.918 13.334 BLAplus DFGAsp-rot-out -101.2362, 162.3019 65.7035, 22.9263 296.0175, -18.1175 -75.1338, -16.684 57.728, 90.9936 -87.9579, -1.2468 in-in in 8.139 Saltbr-in 2.932 HRD-in -80.3523, -46.5517 70.8057, -7.6489 in-out-out SNCioo out-out ActLoopNT-out 7.213 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -154.8117, 163.1472 APE9-dihe-in -110.4807, 104.3122 APE8-dihe-out -59.7288, -18.7285 APE8-rot-na 334.721 APE67-dihe-in -68.6335, -11.7253 -64.2068, -25.2113 APE12-dist-na 16.031 APE11-dist-na 20.139 APE10-dist-na 18.09 APE9-dist-na 11.151 None None None XRAY 1.97 0.19 0.237 B 292 287 2 0 0 0 [[472, 750]] 1.0 9vmb TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9VMBC 457 756 806.0 A1ESX:801 Type1 Inactive DFGin 4.945 13.666 BLAplus DFGAsp-rot-out -103.8136, 162.5884 63.5687, 24.7591 293.6162, -20.9054 -75.1988, -20.3203 56.9995, 90.1495 -91.5147, 3.3859 in-in in 8.479 Saltbr-in 3.31 HRD-in -72.8221, -49.2111 77.839, -8.105 in-out-out SNCioo out-out ActLoopNT-out 7.476 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -157.0324, 160.7269 APE9-dihe-in -107.8221, 103.0352 APE8-dihe-out -59.0895, -17.7937 APE8-rot-na 339.4939 APE67-dihe-in -70.5257, -10.852 -59.7611, -29.5081 APE12-dist-na 15.382 APE11-dist-na 19.602 APE10-dist-na 17.694 APE9-dist-na 11.087 None None None XRAY 1.97 0.19 0.237 C 292 286 2 0 0 0 [[472, 750]] 1.0 9vmb TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9VMBD 462 756 806.0 A1ESX:801 Type1 Inactive DFGin 4.791 13.46 BLAplus DFGAsp-rot-out -100.7828, 162.3753 66.1417, 19.9883 295.7498, -20.8087 -67.6844, -21.8861 57.61, 88.7193 -92.2668, 3.4935 in-out in 8.295 Saltbr-out 3.757 HRD-in -74.0736, -49.8159 78.6982, -9.5659 out-out-out SNCooo out-out ActLoopNT-out 7.159 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -147.9897, 158.6846 APE9-dihe-in -103.9422, 104.6784 APE8-dihe-out -56.8069, -24.4311 APE8-rot-na 333.5062 APE67-dihe-in -75.6433, -10.8102 -61.0327, -20.764 APE12-dist-na 15.923 APE11-dist-na 20.119 APE10-dist-na 17.988 APE9-dist-na 11.1 None None None XRAY 1.97 0.19 0.237 D 292 281 2 0 0 0 [[472, 750]] 1.0 9vmb TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9D1XA 461 754 806.0 A1A6M:2001 Type1 Inactive DFGin 5.12 12.632 BLAplus DFGAsp-rot-out -108.03, 159.86 61.02, 36.65 294.48, -3.42 -81.76, -20.43 56.47, 81.47 -95.6, 7.99 in-in in 7.873 Saltbr-in 3.088 HRD-in -69.72, -49.85 77.77, -9.05 in-out-out SNCioo out-out ActLoopNT-out 7.414 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -149.56, 157.12 APE9-dihe-in -112.69, 98.2 APE8-dihe-out -58.57, -23.42 APE8-rot-na 337.44 APE67-dihe-in -70.39, -9.82 -57.35, -25.35 APE12-dist-na 16.005 APE11-dist-na 20.086 APE10-dist-na 17.503 APE9-dist-na 11.305 P572S,P573G None None XRAY 1.6 0.18 0.19 A 297 282 0 0 0 0 [[472, 750]] 1.0 9d1x TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9CD7A 451 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.019 12.728 BLAplus DFGAsp-rot-out -114.49, 161.16 51.06, 50.03 295.69, -1.49 -90.62, -20.91 50.11, 84.08 -82.82, 141.47 in-in in 7.095 Saltbr-in 2.583 HRD-in -75.51, -51.62 85.64, -15.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 85.15 APE8-dihe-out -64.87, -3.22 APE8-rot-na 28.88 APE67-dihe-in -77.21, -9.06 -69.64, -25.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.346 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 A 312 276 29 0 0 17 [[472, 750]] 1.0 9cd7 TYR_FGFR3_HUMAN TYR 2.1e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9CD7B 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.065 12.859 BLAplus DFGAsp-rot-out -114.57, 159.12 51.43, 51.5 294.2, 2.36 -92.22, -19.36 49.89, 84.09 -76.73, -39.85 in-in in 7.413 Saltbr-in 2.597 HRD-in -74.94, -51.38 85.94, -16.13 in-out-out SNCioo out-out ActLoopNT-out 7.599 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.12 APE8-dihe-out -65.12, -2.8 APE8-rot-na 29.36 APE67-dihe-in -77.72, -8.63 -66.93, -28.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.217 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 B 312 278 20 0 0 6 [[472, 750]] 1.0 9cd7 TYR_FGFR3_HUMAN TYR 2.1e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
9CD7C 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.055 12.917 BLAplus DFGAsp-rot-out -113.11, 157.29 52.27, 52.26 295.83, 0.87 -91.9, -19.06 50.44, 84.08 -76.91, -39.15 in-in in 7.421 Saltbr-in 2.602 HRD-in -75.28, -51.41 85.96, -15.25 in-out-out SNCioo out-out ActLoopNT-out 7.712 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.75 APE8-dihe-out -72.0, 23.1 APE8-rot-na 34.26 APE67-dihe-in -76.94, -9.16 -66.89, -26.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 10.796 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 C 312 278 20 0 0 6 [[472, 750]] 1.0 9cd7 TYR_FGFR3_HUMAN TYR 2.1e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDVA 458 755 806.0 WIQ:1003 Type1.5_Back Inactive DFGin 6.001 13.476 BLAplus DFGAsp-rot-in -124.26, 161.29 66.5, 36.68 236.27, 38.57 -91.33, -43.75 46.96, 90.73 -84.73, 13.25 in-in in 7.661 Saltbr-in 2.94 HRD-in -66.26, -46.33 75.0, -11.55 in-out-out SNCioo out-out ActLoopNT-out 8.16 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -144.63, 151.27 APE9-dihe-in -107.88, 92.32 APE8-dihe-out -54.6, -21.22 APE8-rot-na 338.66 APE67-dihe-in -68.84, -8.83 -57.22, -29.15 APE12-dist-na 15.956 APE11-dist-na 19.998 APE10-dist-na 17.285 APE9-dist-na 11.612 V555M None None XRAY 2.348 0.237 0.261 A 297 279 7 0 0 7 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.6e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDVB 455 755 806.0 WIQ:803 Type1.5_Back Inactive DFGin 5.481 13.254 BLAplus DFGAsp-rot-in -124.6, 164.38 63.05, 27.71 239.92, 31.12 -82.13, -38.21 55.85, 89.15 -91.32, 13.57 in-in in 7.68 Saltbr-in 2.904 HRD-in -63.59, -46.44 79.4, -13.95 in-out-out SNCioo out-out ActLoopNT-out 8.907 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -136.87, 152.88 APE9-dihe-in -110.79, 96.93 APE8-dihe-out -58.89, -20.81 APE8-rot-na 338.74 APE67-dihe-in -70.46, -8.74 -52.69, -32.19 APE12-dist-na 15.479 APE11-dist-na 19.386 APE10-dist-na 16.703 APE9-dist-na 11.424 V555M None None XRAY 2.348 0.237 0.261 B 297 281 8 0 0 8 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.6e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDVC 458 755 806.0 WIQ:1004 Type1.5_Back Inactive DFGin 6.071 13.431 BLAplus DFGAsp-rot-in -124.65, 164.21 70.39, 38.16 222.01, 54.2 -109.8, -21.91 57.41, 87.59 -78.9, -34.05 in-in in 7.655 Saltbr-in 2.888 HRD-in -64.72, -49.48 77.07, -10.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 91.25 APE8-dihe-out -54.32, -20.59 APE8-rot-na 338.75 APE67-dihe-in -71.87, -8.91 -59.36, -26.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.626 V555M None None XRAY 2.348 0.237 0.261 C 297 269 17 0 0 16 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.6e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDTB 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.71 BLAplus DFGAsp-rot-out -108.64, 157.87 56.15, 40.62 295.75, -51.28 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.445 Saltbr-out 5.398 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.867 ActLoopCT-out TYR APEdihe_nooai APEdist_aaaa APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.666 APE9-dist-na 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297 283 3 0 0 3 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDTC 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.824 BLAplus DFGAsp-rot-out -109.74, 157.08 55.91, 40.67 296.56, -52.6 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.103 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.87 ActLoopCT-out TYR APEdihe_nooai APEdist_aaaa APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.405 APE9-dist-na 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297 284 4 0 0 4 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
8UDUA 460 756 806.0 WIQ:61002 Type1.5_Back Inactive DFGin 5.761 13.529 BLBplus DFGAsp-rot-in -121.3, 171.32 71.72, 21.7 212.76, 42.72 -99.77, 166.76 66.11, 93.34 95.58, -59.45 in-in in 7.917 Saltbr-in 2.734 HRD-in -77.2, -48.45 77.61, -12.83 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -71.65, 162.44 APE9-dihe-in -54.1, 129.25 APE8-dihe-in -83.64, 61.19 APE8-rot-na 34.62 APE67-dihe-in -73.43, -8.03 -52.16, -35.97 APE12-dist-na 999.0 APE11-dist-na 14.232 APE10-dist-na 17.747 APE9-dist-na 8.253 P572S,P573G None None XRAY 1.737 0.231 0.256 A 297 277 8 0 0 8 [[472, 750]] 1.0 8udu TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3

TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 28
Active chains: 6
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 20 71.4% 9D1XA
DFGin BLAminus 7 25.0% AF-P22607-K1A
DFGin BLBplus 1 3.6% 8UDUA

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FGFR3_HUMAN 4K33A P22607 459 755 806.0 ACP:801 ATPlike Active DFGin 6.252 13.787 BLAminus DFGAsp-rot-in -133.88, -173.58 58.49, 82.81 197.25, -16.95 -96.43, 27.55 291.81, 80.95 -59.32, -31.32 in-in in 8.211 Saltbr-in 2.895 HRD-in -87.09, -47.34 67.06, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -55.89, 133.11 APE9-dihe-in -125.43, 130.21 APE8-dihe-in -78.76, 72.58 APE8-rot-na 29.71 APE67-dihe-in -71.45, -4.47 -50.14, -48.75 APE12-dist-na 13.31 APE11-dist-na 9.602 APE10-dist-na 8.305 APE9-dist-na 6.873 C482A,C582S,K650E None None XRAY 2.341 0.181 0.228 A 325 293 4 0 0 0 [[472, 750]] 1.0 4k33 Homo sapiens TYR_FGFR3_HUMAN TYR 2.4e-104 354.2 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN AF-P22607-K1A P22607 464 758 806.0 No_ligand No_ligand Active DFGin 6.562 13.72 BLAminus DFGAsp-rot-in -135.6, -172.84 54.36, 70.3 200.96, 24.32 -87.69, 11.11 291.08, 95.72 -59.35, -30.65 in-in in 7.439 Saltbr-in 2.65 HRD-in -71.1, -43.09 66.59, -18.9 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -62.08, 128.6 APE9-dihe-in -136.51, 151.31 APE8-dihe-in -81.26, 77.84 APE8-rot-na 37.52 APE67-dihe-in -66.67, -14.17 -46.27, -41.56 APE12-dist-na 14.39 APE11-dist-na 9.904 APE10-dist-na 9.996 APE9-dist-na 6.521 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[472, 750]] 1.0 AF-P22607-K1 Homo sapiens TYR_FGFR3_HUMAN TYR 1.7e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN AF-P22607-K3A P22607 464 758 806.0 No_ligand No_ligand Active DFGin 6.362 13.763 BLAminus DFGAsp-rot-in -140.11, -178.74 60.69, 64.92 205.01, 9.05 -81.11, 10.08 291.09, 95.14 -60.2, -27.32 in-in in 7.694 Saltbr-in 2.724 HRD-in -81.64, -44.23 60.23, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -64.46, 141.09 APE9-dihe-in -143.98, 144.08 APE8-dihe-in -81.78, 61.47 APE8-rot-na 36.97 APE67-dihe-in -68.61, -8.42 -45.34, -43.48 APE12-dist-na 14.454 APE11-dist-na 10.934 APE10-dist-na 10.364 APE9-dist-na 6.946 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[472, 750]] 1.0 AF-P22607-K3 Homo sapiens TYR_FGFR3_HUMAN TYR 1.7e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 6LVMA P22607 472 755 806.0 EVR:60801 Type1.5_Back Active DFGin 6.528 14.251 BLAminus DFGAsp-rot-in -141.75, -180.0 67.67, 74.35 212.38, -7.8 -89.33, 29.0 297.0, 117.38 -56.22, -44.89 in-in in 7.87 Saltbr-in 3.304 HRD-in -81.99, -57.17 74.69, 3.13 in-in-in SNCiii in-in ActLoopNT-in 3.023 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -86.44, 126.31 APE9-dihe-in -128.79, 145.49 APE8-dihe-in -85.23, 77.25 APE8-rot-na 30.53 APE67-dihe-in -75.5, -6.21 -67.03, -34.23 APE12-dist-na 14.131 APE11-dist-na 10.493 APE10-dist-na 10.62 APE9-dist-na 6.82 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.53 0.211 0.279 A 313 276 8 0 0 0 [[472, 750]] 1.0 6lvm Homo sapiens TYR_FGFR3_HUMAN TYR 2.1e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 7DHLA P22607 472 755 806.0 H6X:60801 Type1.5_Back Active DFGin 5.905 13.891 BLAminus DFGAsp-rot-in -128.75, 172.71 75.89, 84.08 214.6, -2.2 -98.64, 30.77 301.65, 163.04 -59.86, -43.17 in-in in 7.804 Saltbr-in 3.205 HRD-in -74.83, -62.31 81.14, 3.67 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -89.21, 114.53 APE9-dihe-in -123.29, 143.17 APE8-dihe-in -76.55, 75.16 APE8-rot-na 29.19 APE67-dihe-in -80.84, -3.09 -66.95, -32.19 APE12-dist-na 14.415 APE11-dist-na 10.488 APE10-dist-na 10.067 APE9-dist-na 6.821 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.57 0.197 0.254 A 313 277 7 0 0 0 [[472, 750]] 1.0 7dhl Homo sapiens TYR_FGFR3_HUMAN TYR 2.1e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDUB P22607 459 755 806.0 WIQ:61002 Type1.5_Front Active DFGin 6.421 14.415 BLAminus DFGAsp-rot-in -138.69, 176.26 64.2, 86.01 192.54, -15.43 -100.28, 24.84 287.71, 79.66 -57.6, -41.09 in-in in 8.185 Saltbr-in 2.946 HRD-in -71.69, -47.92 71.62, 0.22 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -67.88, 155.75 APE9-dihe-in -122.51, 89.95 APE8-dihe-in -81.37, 70.05 APE8-rot-na 30.61 APE67-dihe-in -66.22, -12.9 -45.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 7.661 APE10-dist-na 8.489 APE9-dist-na 7.717 P572S,P573G None None XRAY 1.737 0.231 0.256 B 297 276 9 0 0 1 [[472, 750]] 1.0 8udu Homo sapiens TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9KFUA P22607 448 756 806.0 A1L5T:801 Type1 Inactive DFGin 7.019 14.492 BLAminus DFGAsp-rot-out -131.22, -178.97 62.43, 68.96 282.46, 4.78 -89.65, 16.94 287.35, 89.22 -61.48, -27.48 in-in in 7.689 Saltbr-in 2.766 HRD-in -73.03, -51.34 76.73, -9.72 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -98.53, 13.75 APE9-dihe-in -98.46, 127.45 APE8-dihe-in -57.08, 120.6 APE8-rot-na 333.93 APE67-dihe-in -72.45, -11.1 -67.2, -26.43 APE12-dist-na 9.97 APE11-dist-na 10.764 APE10-dist-na 7.042 APE9-dist-na 4.799 None None None XRAY 1.4 0.229 0.251 A 309 288 21 0 0 6 [[472, 750]] 1.0 9kfu Homo sapiens TYR_FGFR3_HUMAN TYR 1.8e-104 354.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 6PNXA P22607 456 757 806.0 ACP:801 ATPlike Inactive DFGin 5.183 13.257 BLAplus DFGAsp-rot-out -117.43, 165.96 59.53, 36.21 289.47, -0.22 -90.35, -22.61 56.49, 88.29 -100.71, 20.75 in-out in 7.758 Saltbr-out 3.892 HRD-in -72.74, -43.96 72.66, -12.59 out-out-out SNCooo out-out ActLoopNT-out 8.611 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out 61.32, -168.18 APE9-dihe-in -95.45, 138.6 APE8-dihe-in -83.08, 62.92 APE8-rot-na 32.84 APE67-dihe-in -77.59, -4.01 -63.19, -31.79 APE12-dist-na 17.76 APE11-dist-na 14.387 APE10-dist-na 16.475 APE9-dist-na 7.98 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 A 324 291 11 0 0 0 [[472, 750]] 1.0 6pnx Homo sapiens TYR_FGFR3_HUMAN TYR 2.6e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 6PNXB P22607 455 756 806.0 ACP:801 ATPlike Inactive DFGin 5.102 12.88 BLAplus DFGAsp-rot-out -116.22, 163.18 57.59, 45.48 292.51, -6.63 -96.33, -11.84 56.51, 88.18 -107.89, 22.55 in-in in 7.372 Saltbr-in 2.381 HRD-in -94.02, -38.66 69.29, -17.12 in-out-out SNCioo out-out ActLoopNT-out 4.149 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out 54.33, 74.29 APE9-dihe-in -157.39, 146.53 APE8-dihe-in -79.85, 92.16 APE8-rot-na 29.38 APE67-dihe-in -64.97, -14.94 -62.55, -40.44 APE12-dist-na 17.529 APE11-dist-na 16.958 APE10-dist-na 14.632 APE9-dist-na 7.491 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 B 324 294 8 0 0 0 [[472, 750]] 1.0 6pnx Homo sapiens TYR_FGFR3_HUMAN TYR 2.6e-104 354.1 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDTA P22607 457 756 806.0 MLT:61001,MLT:61002,WGF:61003 Allosteric,Allosteric,Type1.5_Front Inactive DFGin 5.441 13.493 BLAplus DFGAsp-rot-out -114.8, 158.79 55.69, 43.2 295.67, -51.96 -82.19, -34.37 42.84, 89.08 -83.27, -4.41 in-out in 8.383 Saltbr-out 5.287 HRD-in -68.34, -46.54 75.89, -9.4 out-out-out SNCooo out-out ActLoopNT-out 7.921 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.29 APE8-dihe-out -63.06, -32.23 APE8-rot-na 340.92 APE67-dihe-in -68.35, -26.42 -62.13, -28.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.198 P572S,P573G None None XRAY 2.829 0.263 0.274 A 297 284 4 0 0 4 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9VM9A P22607 456 756 806.0 A1ESW:801 Type1 Inactive DFGin 4.966 13.492 BLAplus DFGAsp-rot-out -119.2253, 164.0599 63.1421, 28.0452 298.4088, -20.5723 -80.6137, -19.722 58.8265, 88.3498 -89.4979, 3.838 in-in in 8.227 Saltbr-in 3.087 HRD-in -83.5015, -38.9421 67.609, -4.9778 in-out-out SNCioo out-out ActLoopNT-out 7.488 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -161.4206, 160.008 APE9-dihe-in -107.118, 107.4877 APE8-dihe-out -62.9034, -10.7817 APE8-rot-na 339.842 APE67-dihe-in -73.7411, -10.7298 -67.7033, -23.1684 APE12-dist-na 16.035 APE11-dist-na 20.242 APE10-dist-na 18.306 APE9-dist-na 11.034 None None None XRAY 2.65 0.262 0.312 A 292 287 2 0 0 0 [[472, 750]] 1.0 9vm9 Homo sapiens TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9VM9B P22607 457 755 806.0 A1ESW:801 Type1 Inactive DFGin 4.897 13.418 BLAplus DFGAsp-rot-out -118.1146, 165.3887 61.3627, 30.6061 300.2288, -39.0485 -82.5158, -20.0989 61.779, 89.971 -89.4214, 0.2931 in-out in 8.194 Saltbr-out 4.343 HRD-in -78.6959, -44.4486 76.8665, -18.6531 out-out-out SNCooo out-out ActLoopNT-out 7.085 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -164.1861, 155.5897 APE9-dihe-in -100.8219, 112.393 APE8-dihe-out -62.6805, -15.6899 APE8-rot-na 338.614 APE67-dihe-in -73.9513, -16.6434 -66.7504, -20.5086 APE12-dist-na 15.925 APE11-dist-na 20.12 APE10-dist-na 18.159 APE9-dist-na 10.971 None None None XRAY 2.65 0.262 0.312 B 292 285 2 0 0 0 [[472, 750]] 1.0 9vm9 Homo sapiens TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9VM9C P22607 462 756 806.0 A1ESW:801 Type1 Inactive DFGin 4.981 13.216 BLAplus DFGAsp-rot-out -117.2651, 166.7429 62.5729, 25.3486 294.8151, -23.2774 -78.3678, -24.8213 55.9088, 91.3153 -86.7896, 3.5439 in-out in 8.16 Saltbr-out 4.018 HRD-in -78.4924, -39.3464 68.6842, -7.6966 out-out-out SNCooo out-out ActLoopNT-out 7.457 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -158.0344, 156.8491 APE9-dihe-in -101.6007, 111.3298 APE8-dihe-out -63.9614, -13.0871 APE8-rot-na 340.3288 APE67-dihe-in -75.3695, -10.2261 -66.4686, -23.6326 APE12-dist-na 15.991 APE11-dist-na 20.237 APE10-dist-na 18.228 APE9-dist-na 11.099 None None None XRAY 2.65 0.262 0.312 C 292 281 2 0 0 0 [[472, 750]] 1.0 9vm9 Homo sapiens TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9VM9D P22607 459 756 806.0 A1ESW:802 Type1 Inactive DFGin 5.041 13.235 BLAplus DFGAsp-rot-out -113.9306, 165.2223 61.6624, 22.0486 298.8167, -19.0768 -73.4743, -22.6442 57.5347, 87.6331 -90.2727, 1.583 in-none in 8.154 Saltbr-none 999.0 HRD-in -71.1771, -50.6322 76.5196, -3.1321 none-out-out SNCnoo out-out ActLoopNT-out 7.536 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -152.0562, 156.2583 APE9-dihe-in -103.8127, 110.8616 APE8-dihe-out -64.3171, -15.4813 APE8-rot-na 338.7707 APE67-dihe-in -74.9476, -13.3888 -65.6453, -22.3392 APE12-dist-na 15.838 APE11-dist-na 20.012 APE10-dist-na 17.941 APE9-dist-na 10.904 None None None XRAY 2.65 0.262 0.312 D 292 284 2 0 0 0 [[472, 750]] 1.0 9vm9 Homo sapiens TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9VMBA P22607 456 756 806.0 A1ESX:801 Type1 Inactive DFGin 4.993 13.461 BLAplus DFGAsp-rot-out -106.5175, 161.6879 65.3472, 18.46 293.7428, -21.3049 -70.1659, -20.2448 57.7617, 91.439 -90.0125, 3.5321 in-in in 8.114 Saltbr-in 3.154 HRD-in -73.0442, -49.8537 77.8647, -11.6549 in-out-out SNCioo out-out ActLoopNT-out 7.526 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -152.7604, 163.4923 APE9-dihe-in -109.8641, 99.2708 APE8-dihe-out -57.3812, -21.1375 APE8-rot-na 333.2281 APE67-dihe-in -72.5898, -10.0313 -56.6744, -26.6672 APE12-dist-na 15.764 APE11-dist-na 19.999 APE10-dist-na 18.055 APE9-dist-na 11.148 None None None XRAY 1.97 0.19 0.237 A 292 287 2 0 0 0 [[472, 750]] 1.0 9vmb Homo sapiens TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9VMBB P22607 456 756 806.0 A1ESX:801 Type1 Inactive DFGin 4.918 13.334 BLAplus DFGAsp-rot-out -101.2362, 162.3019 65.7035, 22.9263 296.0175, -18.1175 -75.1338, -16.684 57.728, 90.9936 -87.9579, -1.2468 in-in in 8.139 Saltbr-in 2.932 HRD-in -80.3523, -46.5517 70.8057, -7.6489 in-out-out SNCioo out-out ActLoopNT-out 7.213 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -154.8117, 163.1472 APE9-dihe-in -110.4807, 104.3122 APE8-dihe-out -59.7288, -18.7285 APE8-rot-na 334.721 APE67-dihe-in -68.6335, -11.7253 -64.2068, -25.2113 APE12-dist-na 16.031 APE11-dist-na 20.139 APE10-dist-na 18.09 APE9-dist-na 11.151 None None None XRAY 1.97 0.19 0.237 B 292 287 2 0 0 0 [[472, 750]] 1.0 9vmb Homo sapiens TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9VMBC P22607 457 756 806.0 A1ESX:801 Type1 Inactive DFGin 4.945 13.666 BLAplus DFGAsp-rot-out -103.8136, 162.5884 63.5687, 24.7591 293.6162, -20.9054 -75.1988, -20.3203 56.9995, 90.1495 -91.5147, 3.3859 in-in in 8.479 Saltbr-in 3.31 HRD-in -72.8221, -49.2111 77.839, -8.105 in-out-out SNCioo out-out ActLoopNT-out 7.476 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -157.0324, 160.7269 APE9-dihe-in -107.8221, 103.0352 APE8-dihe-out -59.0895, -17.7937 APE8-rot-na 339.4939 APE67-dihe-in -70.5257, -10.852 -59.7611, -29.5081 APE12-dist-na 15.382 APE11-dist-na 19.602 APE10-dist-na 17.694 APE9-dist-na 11.087 None None None XRAY 1.97 0.19 0.237 C 292 286 2 0 0 0 [[472, 750]] 1.0 9vmb Homo sapiens TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9VMBD P22607 462 756 806.0 A1ESX:801 Type1 Inactive DFGin 4.791 13.46 BLAplus DFGAsp-rot-out -100.7828, 162.3753 66.1417, 19.9883 295.7498, -20.8087 -67.6844, -21.8861 57.61, 88.7193 -92.2668, 3.4935 in-out in 8.295 Saltbr-out 3.757 HRD-in -74.0736, -49.8159 78.6982, -9.5659 out-out-out SNCooo out-out ActLoopNT-out 7.159 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -147.9897, 158.6846 APE9-dihe-in -103.9422, 104.6784 APE8-dihe-out -56.8069, -24.4311 APE8-rot-na 333.5062 APE67-dihe-in -75.6433, -10.8102 -61.0327, -20.764 APE12-dist-na 15.923 APE11-dist-na 20.119 APE10-dist-na 17.988 APE9-dist-na 11.1 None None None XRAY 1.97 0.19 0.237 D 292 281 2 0 0 0 [[472, 750]] 1.0 9vmb Homo sapiens TYR_FGFR3_HUMAN TYR 8.1e-105 355.8 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9D1XA P22607 461 754 806.0 A1A6M:2001 Type1 Inactive DFGin 5.12 12.632 BLAplus DFGAsp-rot-out -108.03, 159.86 61.02, 36.65 294.48, -3.42 -81.76, -20.43 56.47, 81.47 -95.6, 7.99 in-in in 7.873 Saltbr-in 3.088 HRD-in -69.72, -49.85 77.77, -9.05 in-out-out SNCioo out-out ActLoopNT-out 7.414 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -149.56, 157.12 APE9-dihe-in -112.69, 98.2 APE8-dihe-out -58.57, -23.42 APE8-rot-na 337.44 APE67-dihe-in -70.39, -9.82 -57.35, -25.35 APE12-dist-na 16.005 APE11-dist-na 20.086 APE10-dist-na 17.503 APE9-dist-na 11.305 P572S,P573G None None XRAY 1.6 0.18 0.19 A 297 282 0 0 0 0 [[472, 750]] 1.0 9d1x Homo sapiens TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9CD7A P22607 451 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.019 12.728 BLAplus DFGAsp-rot-out -114.49, 161.16 51.06, 50.03 295.69, -1.49 -90.62, -20.91 50.11, 84.08 -82.82, 141.47 in-in in 7.095 Saltbr-in 2.583 HRD-in -75.51, -51.62 85.64, -15.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 85.15 APE8-dihe-out -64.87, -3.22 APE8-rot-na 28.88 APE67-dihe-in -77.21, -9.06 -69.64, -25.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.346 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 A 312 276 29 0 0 17 [[472, 750]] 1.0 9cd7 Homo sapiens TYR_FGFR3_HUMAN TYR 2.1e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9CD7B P22607 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.065 12.859 BLAplus DFGAsp-rot-out -114.57, 159.12 51.43, 51.5 294.2, 2.36 -92.22, -19.36 49.89, 84.09 -76.73, -39.85 in-in in 7.413 Saltbr-in 2.597 HRD-in -74.94, -51.38 85.94, -16.13 in-out-out SNCioo out-out ActLoopNT-out 7.599 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.12 APE8-dihe-out -65.12, -2.8 APE8-rot-na 29.36 APE67-dihe-in -77.72, -8.63 -66.93, -28.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.217 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 B 312 278 20 0 0 6 [[472, 750]] 1.0 9cd7 Homo sapiens TYR_FGFR3_HUMAN TYR 2.1e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 9CD7C P22607 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.055 12.917 BLAplus DFGAsp-rot-out -113.11, 157.29 52.27, 52.26 295.83, 0.87 -91.9, -19.06 50.44, 84.08 -76.91, -39.15 in-in in 7.421 Saltbr-in 2.602 HRD-in -75.28, -51.41 85.96, -15.25 in-out-out SNCioo out-out ActLoopNT-out 7.712 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.75 APE8-dihe-out -72.0, 23.1 APE8-rot-na 34.26 APE67-dihe-in -76.94, -9.16 -66.89, -26.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 10.796 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 C 312 278 20 0 0 6 [[472, 750]] 1.0 9cd7 Homo sapiens TYR_FGFR3_HUMAN TYR 2.1e-104 354.4 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDVA P22607 458 755 806.0 WIQ:1003 Type1.5_Back Inactive DFGin 6.001 13.476 BLAplus DFGAsp-rot-in -124.26, 161.29 66.5, 36.68 236.27, 38.57 -91.33, -43.75 46.96, 90.73 -84.73, 13.25 in-in in 7.661 Saltbr-in 2.94 HRD-in -66.26, -46.33 75.0, -11.55 in-out-out SNCioo out-out ActLoopNT-out 8.16 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -144.63, 151.27 APE9-dihe-in -107.88, 92.32 APE8-dihe-out -54.6, -21.22 APE8-rot-na 338.66 APE67-dihe-in -68.84, -8.83 -57.22, -29.15 APE12-dist-na 15.956 APE11-dist-na 19.998 APE10-dist-na 17.285 APE9-dist-na 11.612 V555M None None XRAY 2.348 0.237 0.261 A 297 279 7 0 0 7 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.6e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDVB P22607 455 755 806.0 WIQ:803 Type1.5_Back Inactive DFGin 5.481 13.254 BLAplus DFGAsp-rot-in -124.6, 164.38 63.05, 27.71 239.92, 31.12 -82.13, -38.21 55.85, 89.15 -91.32, 13.57 in-in in 7.68 Saltbr-in 2.904 HRD-in -63.59, -46.44 79.4, -13.95 in-out-out SNCioo out-out ActLoopNT-out 8.907 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -136.87, 152.88 APE9-dihe-in -110.79, 96.93 APE8-dihe-out -58.89, -20.81 APE8-rot-na 338.74 APE67-dihe-in -70.46, -8.74 -52.69, -32.19 APE12-dist-na 15.479 APE11-dist-na 19.386 APE10-dist-na 16.703 APE9-dist-na 11.424 V555M None None XRAY 2.348 0.237 0.261 B 297 281 8 0 0 8 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.6e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDVC P22607 458 755 806.0 WIQ:1004 Type1.5_Back Inactive DFGin 6.071 13.431 BLAplus DFGAsp-rot-in -124.65, 164.21 70.39, 38.16 222.01, 54.2 -109.8, -21.91 57.41, 87.59 -78.9, -34.05 in-in in 7.655 Saltbr-in 2.888 HRD-in -64.72, -49.48 77.07, -10.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 91.25 APE8-dihe-out -54.32, -20.59 APE8-rot-na 338.75 APE67-dihe-in -71.87, -8.91 -59.36, -26.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 11.626 V555M None None XRAY 2.348 0.237 0.261 C 297 269 17 0 0 16 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.6e-105 356.6 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDTB P22607 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.71 BLAplus DFGAsp-rot-out -108.64, 157.87 56.15, 40.62 295.75, -51.28 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.445 Saltbr-out 5.398 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.867 ActLoopCT-out TYR APEdihe_nooai APEdist_aaaa APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.666 APE9-dist-na 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297 283 3 0 0 3 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDTC P22607 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.824 BLAplus DFGAsp-rot-out -109.74, 157.08 55.91, 40.67 296.56, -52.6 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.103 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.87 ActLoopCT-out TYR APEdihe_nooai APEdist_aaaa APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.405 APE9-dist-na 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297 284 4 0 0 4 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3_HUMAN 8UDUA P22607 460 756 806.0 WIQ:61002 Type1.5_Back Inactive DFGin 5.761 13.529 BLBplus DFGAsp-rot-in -121.3, 171.32 71.72, 21.7 212.76, 42.72 -99.77, 166.76 66.11, 93.34 95.58, -59.45 in-in in 7.917 Saltbr-in 2.734 HRD-in -77.2, -48.45 77.61, -12.83 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -71.65, 162.44 APE9-dihe-in -54.1, 129.25 APE8-dihe-in -83.64, 61.19 APE8-rot-na 34.62 APE67-dihe-in -73.43, -8.03 -52.16, -35.97 APE12-dist-na 999.0 APE11-dist-na 14.232 APE10-dist-na 17.747 APE9-dist-na 8.253 P572S,P573G None None XRAY 1.737 0.231 0.256 A 297 277 8 0 0 8 [[472, 750]] 1.0 8udu Homo sapiens TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3

TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name