TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 20
Active chains: 6
Uniprot: FGFR3_HUMAN
Kinase Domain Residues: 472 - 750
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 12 60.0% 9D1XA
DFGin BLAminus 7 35.0% AF-P22607-K1A
DFGin BLBplus 1 5.0% 8UDUA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FGFR3 4K33A P22607 459 755 806.0 ACP:801 ATPlike Active DFGin 6.2519 13.787 BLAminus -133.88, -173.58 58.49, 82.81 -96.43, 27.55 291.81, 80.95 -59.32, -31.32 in-in in 8.2114 Saltbr-in 2.895 HRD-in -87.09, -47.34 67.06, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.9905 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.89, 133.11 APE9-dihe-in -125.43, 130.21 APE8-dihe-in -78.76, 72.58 APE8-rot-na 29.71 APE67-dihe-in -71.45, -4.47 -50.14, -48.75 APE12-dist-na 13.3098 APE11-dist-na 9.6016 APE10-dist-na 8.3051 APE9-dist-in 6.8731 C482A,C582S,K650E None None XRAY 2.341 0.181 0.228 A 325.0 293.0 4 30 30 0 [[472, 750]] 1.0 4k33 TYR_FGFR3_HUMAN TYR 2.3e-104 354.2 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 AF-P22607-K1A P22607 464 758 806.0 No_ligand No_ligand Active DFGin 6.5621 13.7198 BLAminus -135.6, -172.84 54.36, 70.3 -87.69, 11.11 291.08, 95.72 -59.35, -30.65 in-in in 7.4386 Saltbr-in 2.6502 HRD-in -71.1, -43.09 66.59, -18.9 in-in-in SNCiii in-in ActLoopNT-in 2.8909 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.08, 128.6 APE9-dihe-in -136.51, 151.31 APE8-dihe-in -81.26, 77.84 APE8-rot-na 37.52 APE67-dihe-in -66.67, -14.17 -46.27, -41.56 APE12-dist-na 14.3905 APE11-dist-na 9.9039 APE10-dist-na 9.996 APE9-dist-in 6.5212 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[472, 750]] 1.0 AF-P22607-K1 TYR_FGFR3_HUMAN TYR 1.6e-104 354.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 AF-P22607-K3A P22607 464 758 806.0 No_ligand No_ligand Active DFGin 6.3619 13.7626 BLAminus -140.11, -178.74 60.69, 64.92 -81.11, 10.08 291.09, 95.14 -60.2, -27.32 in-in in 7.6939 Saltbr-in 2.724 HRD-in -81.64, -44.23 60.23, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.9077 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.46, 141.09 APE9-dihe-in -143.98, 144.08 APE8-dihe-in -81.78, 61.47 APE8-rot-na 36.97 APE67-dihe-in -68.61, -8.42 -45.34, -43.48 APE12-dist-na 14.4543 APE11-dist-na 10.9342 APE10-dist-na 10.3642 APE9-dist-in 6.9461 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[472, 750]] 1.0 AF-P22607-K3 TYR_FGFR3_HUMAN TYR 1.6e-104 354.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 6LVMA P22607 472 755 806.0 EVR:60801 Type1.5_Back Active DFGin 6.5277 14.2505 BLAminus -141.75, -180.0 67.67, 74.35 -89.33, 29.0 297.0, 117.38 -56.22, -44.89 in-in in 7.87 Saltbr-in 3.3042 HRD-in -81.99, -57.17 74.69, 3.13 in-in-in SNCiii in-in ActLoopNT-in 3.0228 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.44, 126.31 APE9-dihe-in -128.79, 145.49 APE8-dihe-in -85.23, 77.25 APE8-rot-na 30.53 APE67-dihe-in -75.5, -6.21 -67.03, -34.23 APE12-dist-na 14.1311 APE11-dist-na 10.493 APE10-dist-na 10.6197 APE9-dist-in 6.8201 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.53 0.211 0.279 A 313.0 276.0 8 30 30 0 [[472, 750]] 1.0 6lvm TYR_FGFR3_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 7DHLA P22607 472 755 806.0 H6X:60801 Type1.5_Back Active DFGin 5.9046 13.8906 BLAminus -128.75, 172.71 75.89, 84.08 -98.64, 30.77 301.65, 163.04 -59.86, -43.17 in-in in 7.8037 Saltbr-in 3.2049 HRD-in -74.83, -62.31 81.14, 3.67 in-in-in SNCiii in-in ActLoopNT-in 2.9371 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.21, 114.53 APE9-dihe-in -123.29, 143.17 APE8-dihe-in -76.55, 75.16 APE8-rot-na 29.19 APE67-dihe-in -80.84, -3.09 -66.95, -32.19 APE12-dist-na 14.4146 APE11-dist-na 10.4878 APE10-dist-na 10.067 APE9-dist-in 6.8206 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.57 0.197 0.254 A 313.0 277.0 7 30 30 0 [[472, 750]] 1.0 7dhl TYR_FGFR3_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 8UDUB P22607 459 755 806.0 WIQ:61002 Type1.5_Front Active DFGin 6.4209 14.4148 BLAminus -138.69, 176.26 64.2, 86.01 -100.28, 24.84 287.71, 79.66 -57.6, -41.09 in-in in 8.1853 Saltbr-in 2.9464 HRD-in -71.69, -47.92 71.62, 0.22 in-in-in SNCiii in-in ActLoopNT-in 2.9471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 155.75 APE9-dihe-in -122.51, 89.95 APE8-dihe-in -81.37, 70.05 APE8-rot-na 30.61 APE67-dihe-in -66.22, -12.9 -45.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 7.6606 APE10-dist-na 8.4893 APE9-dist-in 7.717 P572S,P573G None None XRAY 1.737 0.231 0.256 B 297.0 276.0 9 30 29 1 [[472, 750]] 1.0 8udu TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 9KFUA P22607 448 756 806.0 A1L5T:801 Type1 Inactive DFGin 7.0189 14.4915 BLAminus -131.22, -178.97 62.43, 68.96 -89.65, 16.94 287.35, 89.22 -61.48, -27.48 in-in in 7.689 Saltbr-in 2.7663 HRD-in -73.03, -51.34 76.73, -9.72 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.53, 13.75 APE9-dihe-in -98.46, 127.45 APE8-dihe-in -57.08, 120.6 APE8-rot-na 333.93 APE67-dihe-in -72.45, -11.1 -67.2, -26.43 APE12-dist-na 9.9702 APE11-dist-na 10.7644 APE10-dist-na 7.0416 APE9-dist-in 4.7988 None None None XRAY 1.4 0.229 0.251 A 309.0 288.0 21 30 24 6 [[472, 750]] 1.0 9kfu TYR_FGFR3_HUMAN TYR 1.7e-104 354.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 6PNXA P22607 456 757 806.0 ACP:801 ATPlike Inactive DFGin 5.1832 13.2568 BLAplus -117.43, 165.96 59.53, 36.21 -90.35, -22.61 56.49, 88.29 -100.71, 20.75 in-out in 7.758 Saltbr-out 3.8922 HRD-in -72.74, -43.96 72.66, -12.59 out-out-out SNCooo out-out ActLoopNT-out 8.6112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 61.32, -168.18 APE9-dihe-in -95.45, 138.6 APE8-dihe-in -83.08, 62.92 APE8-rot-na 32.84 APE67-dihe-in -77.59, -4.01 -63.19, -31.79 APE12-dist-na 17.76 APE11-dist-na 14.3869 APE10-dist-na 16.4747 APE9-dist-in 7.9796 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 A 324.0 291.0 11 30 30 0 [[472, 750]] 1.0 6pnx TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 6PNXB P22607 455 756 806.0 ACP:801 ATPlike Inactive DFGin 5.1024 12.8796 BLAplus -116.22, 163.18 57.59, 45.48 -96.33, -11.84 56.51, 88.18 -107.89, 22.55 in-in in 7.3718 Saltbr-in 2.3809 HRD-in -94.02, -38.66 69.29, -17.12 in-out-out SNCioo out-out ActLoopNT-out 4.1485 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 54.33, 74.29 APE9-dihe-in -157.39, 146.53 APE8-dihe-in -79.85, 92.16 APE8-rot-na 29.38 APE67-dihe-in -64.97, -14.94 -62.55, -40.44 APE12-dist-na 17.5294 APE11-dist-na 16.9582 APE10-dist-na 14.6317 APE9-dist-in 7.491 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 B 324.0 294.0 8 30 30 0 [[472, 750]] 1.0 6pnx TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 8UDTA P22607 457 756 806.0 MLT:61001,MLT:61002,WGF:61003 Allosteric,Allosteric,Type1.5_Front Inactive DFGin 5.4408 13.493 BLAplus -114.8, 158.79 55.69, 43.2 -82.19, -34.37 42.84, 89.08 -83.27, -4.41 in-out in 8.3828 Saltbr-out 5.2872 HRD-in -68.34, -46.54 75.89, -9.4 out-out-out SNCooo out-out ActLoopNT-out 7.9211 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.29 APE8-dihe-out -63.06, -32.23 APE8-rot-na 340.92 APE67-dihe-in -68.35, -26.42 -62.13, -28.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.1982 P572S,P573G None None XRAY 2.829 0.263 0.274 A 297.0 284.0 4 30 26 4 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 9D1XA P22607 461 754 806.0 A1A6M:2001 Type1 Inactive DFGin 5.1196 12.6323 BLAplus -108.03, 159.86 61.02, 36.65 -81.76, -20.43 56.47, 81.47 -95.6, 7.99 in-in in 7.8726 Saltbr-in 3.0881 HRD-in -69.72, -49.85 77.77, -9.05 in-out-out SNCioo out-out ActLoopNT-out 7.4139 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -149.56, 157.12 APE9-dihe-in -112.69, 98.2 APE8-dihe-out -58.57, -23.42 APE8-rot-na 337.44 APE67-dihe-in -70.39, -9.82 -57.35, -25.35 APE12-dist-na 16.0046 APE11-dist-na 20.0862 APE10-dist-na 17.5026 APE9-dist-out 11.3051 P572S,P573G None None XRAY 1.6 0.18 0.19 A 297.0 282.0 0 30 30 0 [[472, 750]] 1.0 9d1x TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 9CD7A P22607 451 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.0186 12.7277 BLAplus -114.49, 161.16 51.06, 50.03 -90.62, -20.91 50.11, 84.08 -82.82, 141.47 in-in in 7.0948 Saltbr-in 2.5832 HRD-in -75.51, -51.62 85.64, -15.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 85.15 APE8-dihe-out -64.87, -3.22 APE8-rot-na 28.88 APE67-dihe-in -77.21, -9.06 -69.64, -25.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.3457 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 A 312.0 276.0 29 30 13 17 [[472, 750]] 1.0 9cd7 TYR_FGFR3_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 9CD7B P22607 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.0653 12.8593 BLAplus -114.57, 159.12 51.43, 51.5 -92.22, -19.36 49.89, 84.09 -76.73, -39.85 in-in in 7.4133 Saltbr-in 2.5967 HRD-in -74.94, -51.38 85.94, -16.13 in-out-out SNCioo out-out ActLoopNT-out 7.5988 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.12 APE8-dihe-out -65.12, -2.8 APE8-rot-na 29.36 APE67-dihe-in -77.72, -8.63 -66.93, -28.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2175 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 B 312.0 278.0 20 30 24 6 [[472, 750]] 1.0 9cd7 TYR_FGFR3_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 9CD7C P22607 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.0552 12.9174 BLAplus -113.11, 157.29 52.27, 52.26 -91.9, -19.06 50.44, 84.08 -76.91, -39.15 in-in in 7.4207 Saltbr-in 2.6017 HRD-in -75.28, -51.41 85.96, -15.25 in-out-out SNCioo out-out ActLoopNT-out 7.7116 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.75 APE8-dihe-out -72.0, 23.1 APE8-rot-na 34.26 APE67-dihe-in -76.94, -9.16 -66.89, -26.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.796 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 C 312.0 278.0 20 30 24 6 [[472, 750]] 1.0 9cd7 TYR_FGFR3_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 8UDVA P22607 458 755 806.0 WIQ:1003 Type1.5_Back Inactive DFGin 6.0012 13.4764 BLAplus -124.26, 161.29 66.5, 36.68 -91.33, -43.75 46.96, 90.73 -84.73, 13.25 in-in in 7.6609 Saltbr-in 2.9402 HRD-in -66.26, -46.33 75.0, -11.55 in-out-out SNCioo out-out ActLoopNT-out 8.16 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -144.63, 151.27 APE9-dihe-in -107.88, 92.32 APE8-dihe-out -54.6, -21.22 APE8-rot-na 338.66 APE67-dihe-in -68.84, -8.83 -57.22, -29.15 APE12-dist-na 15.9556 APE11-dist-na 19.9983 APE10-dist-na 17.2851 APE9-dist-out 11.6116 V555M None None XRAY 2.348 0.237 0.261 A 297.0 279.0 7 30 23 7 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 8UDVB P22607 455 755 806.0 WIQ:803 Type1.5_Back Inactive DFGin 5.4813 13.2542 BLAplus -124.6, 164.38 63.05, 27.71 -82.13, -38.21 55.85, 89.15 -91.32, 13.57 in-in in 7.68 Saltbr-in 2.9036 HRD-in -63.59, -46.44 79.4, -13.95 in-out-out SNCioo out-out ActLoopNT-out 8.9067 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -136.87, 152.88 APE9-dihe-in -110.79, 96.93 APE8-dihe-out -58.89, -20.81 APE8-rot-na 338.74 APE67-dihe-in -70.46, -8.74 -52.69, -32.19 APE12-dist-na 15.4794 APE11-dist-na 19.3858 APE10-dist-na 16.7032 APE9-dist-out 11.4241 V555M None None XRAY 2.348 0.237 0.261 B 297.0 281.0 8 30 22 8 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 8UDVC P22607 458 755 806.0 WIQ:1004 Type1.5_Back Inactive DFGin 6.071 13.4313 BLAplus -124.65, 164.21 70.39, 38.16 -109.8, -21.91 57.41, 87.59 -78.9, -34.05 in-in in 7.6549 Saltbr-in 2.8879 HRD-in -64.72, -49.48 77.07, -10.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 91.25 APE8-dihe-out -54.32, -20.59 APE8-rot-na 338.75 APE67-dihe-in -71.87, -8.91 -59.36, -26.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.6264 V555M None None XRAY 2.348 0.237 0.261 C 297.0 269.0 17 30 14 16 [[472, 750]] 1.0 8udv TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 8UDTB P22607 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.2581 13.7103 BLAplus -108.64, 157.87 56.15, 40.62 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.4451 Saltbr-out 5.3977 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.8672 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.6665 APE9-dist-out 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297.0 283.0 3 30 27 3 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 8UDTC P22607 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.2583 13.8238 BLAplus -109.74, 157.08 55.91, 40.67 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.1026 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.8702 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.4047 APE9-dist-out 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297.0 284.0 4 30 26 4 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 8UDUA P22607 460 756 806.0 WIQ:61002 Type1.5_Back Inactive DFGin 5.7614 13.5292 BLBplus -121.3, 171.32 71.72, 21.7 -99.77, 166.76 66.11, 93.34 95.58, -59.45 in-in in 7.9172 Saltbr-in 2.7343 HRD-in -77.2, -48.45 77.61, -12.83 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.65, 162.44 APE9-dihe-in -54.1, 129.25 APE8-dihe-in -83.64, 61.19 APE8-rot-na 34.62 APE67-dihe-in -73.43, -8.03 -52.16, -35.97 APE12-dist-na 999.0 APE11-dist-na 14.2323 APE10-dist-na 17.7469 APE9-dist-out 8.253 P572S,P573G None None XRAY 1.737 0.231 0.256 A 297.0 277.0 8 30 22 8 [[472, 750]] 1.0 8udu TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3

TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 20
Active chains: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 12 60.0% 9D1XA
DFGin BLAminus 7 35.0% AF-P22607-K1A
DFGin BLBplus 1 5.0% 8UDUA

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FGFR3 FGFR3_HUMAN 4K33A P22607 459 755 806.0 ACP:801 ATPlike Active DFGin 6.2519 13.787 BLAminus -133.88, -173.58 58.49, 82.81 -96.43, 27.55 291.81, 80.95 -59.32, -31.32 in-in in 8.2114 Saltbr-in 2.895 HRD-in -87.09, -47.34 67.06, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.9905 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.89, 133.11 APE9-dihe-in -125.43, 130.21 APE8-dihe-in -78.76, 72.58 APE8-rot-na 29.71 APE67-dihe-in -71.45, -4.47 -50.14, -48.75 APE12-dist-na 13.3098 APE11-dist-na 9.6016 APE10-dist-na 8.3051 APE9-dist-in 6.8731 C482A,C582S,K650E None None XRAY 2.341 0.181 0.228 A 325.0 293.0 4 30 30 0 [[472, 750]] 1.0 4k33 Homo sapiens TYR_FGFR3_HUMAN TYR 2.3e-104 354.2 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN AF-P22607-K1A P22607 464 758 806.0 No_ligand No_ligand Active DFGin 6.5621 13.7198 BLAminus -135.6, -172.84 54.36, 70.3 -87.69, 11.11 291.08, 95.72 -59.35, -30.65 in-in in 7.4386 Saltbr-in 2.6502 HRD-in -71.1, -43.09 66.59, -18.9 in-in-in SNCiii in-in ActLoopNT-in 2.8909 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.08, 128.6 APE9-dihe-in -136.51, 151.31 APE8-dihe-in -81.26, 77.84 APE8-rot-na 37.52 APE67-dihe-in -66.67, -14.17 -46.27, -41.56 APE12-dist-na 14.3905 APE11-dist-na 9.9039 APE10-dist-na 9.996 APE9-dist-in 6.5212 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[472, 750]] 1.0 AF-P22607-K1 Homo sapiens TYR_FGFR3_HUMAN TYR 1.6e-104 354.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN AF-P22607-K3A P22607 464 758 806.0 No_ligand No_ligand Active DFGin 6.3619 13.7626 BLAminus -140.11, -178.74 60.69, 64.92 -81.11, 10.08 291.09, 95.14 -60.2, -27.32 in-in in 7.6939 Saltbr-in 2.724 HRD-in -81.64, -44.23 60.23, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.9077 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.46, 141.09 APE9-dihe-in -143.98, 144.08 APE8-dihe-in -81.78, 61.47 APE8-rot-na 36.97 APE67-dihe-in -68.61, -8.42 -45.34, -43.48 APE12-dist-na 14.4543 APE11-dist-na 10.9342 APE10-dist-na 10.3642 APE9-dist-in 6.9461 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[472, 750]] 1.0 AF-P22607-K3 Homo sapiens TYR_FGFR3_HUMAN TYR 1.6e-104 354.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 6LVMA P22607 472 755 806.0 EVR:60801 Type1.5_Back Active DFGin 6.5277 14.2505 BLAminus -141.75, -180.0 67.67, 74.35 -89.33, 29.0 297.0, 117.38 -56.22, -44.89 in-in in 7.87 Saltbr-in 3.3042 HRD-in -81.99, -57.17 74.69, 3.13 in-in-in SNCiii in-in ActLoopNT-in 3.0228 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.44, 126.31 APE9-dihe-in -128.79, 145.49 APE8-dihe-in -85.23, 77.25 APE8-rot-na 30.53 APE67-dihe-in -75.5, -6.21 -67.03, -34.23 APE12-dist-na 14.1311 APE11-dist-na 10.493 APE10-dist-na 10.6197 APE9-dist-in 6.8201 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.53 0.211 0.279 A 313.0 276.0 8 30 30 0 [[472, 750]] 1.0 6lvm Homo sapiens TYR_FGFR3_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 7DHLA P22607 472 755 806.0 H6X:60801 Type1.5_Back Active DFGin 5.9046 13.8906 BLAminus -128.75, 172.71 75.89, 84.08 -98.64, 30.77 301.65, 163.04 -59.86, -43.17 in-in in 7.8037 Saltbr-in 3.2049 HRD-in -74.83, -62.31 81.14, 3.67 in-in-in SNCiii in-in ActLoopNT-in 2.9371 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.21, 114.53 APE9-dihe-in -123.29, 143.17 APE8-dihe-in -76.55, 75.16 APE8-rot-na 29.19 APE67-dihe-in -80.84, -3.09 -66.95, -32.19 APE12-dist-na 14.4146 APE11-dist-na 10.4878 APE10-dist-na 10.067 APE9-dist-in 6.8206 None PTR577,PTR647,PTR648 PTR577,PTR647,PTR648 XRAY 2.57 0.197 0.254 A 313.0 277.0 7 30 30 0 [[472, 750]] 1.0 7dhl Homo sapiens TYR_FGFR3_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 8UDUB P22607 459 755 806.0 WIQ:61002 Type1.5_Front Active DFGin 6.4209 14.4148 BLAminus -138.69, 176.26 64.2, 86.01 -100.28, 24.84 287.71, 79.66 -57.6, -41.09 in-in in 8.1853 Saltbr-in 2.9464 HRD-in -71.69, -47.92 71.62, 0.22 in-in-in SNCiii in-in ActLoopNT-in 2.9471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.88, 155.75 APE9-dihe-in -122.51, 89.95 APE8-dihe-in -81.37, 70.05 APE8-rot-na 30.61 APE67-dihe-in -66.22, -12.9 -45.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 7.6606 APE10-dist-na 8.4893 APE9-dist-in 7.717 P572S,P573G None None XRAY 1.737 0.231 0.256 B 297.0 276.0 9 30 29 1 [[472, 750]] 1.0 8udu Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 9KFUA P22607 448 756 806.0 A1L5T:801 Type1 Inactive DFGin 7.0189 14.4915 BLAminus -131.22, -178.97 62.43, 68.96 -89.65, 16.94 287.35, 89.22 -61.48, -27.48 in-in in 7.689 Saltbr-in 2.7663 HRD-in -73.03, -51.34 76.73, -9.72 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.53, 13.75 APE9-dihe-in -98.46, 127.45 APE8-dihe-in -57.08, 120.6 APE8-rot-na 333.93 APE67-dihe-in -72.45, -11.1 -67.2, -26.43 APE12-dist-na 9.9702 APE11-dist-na 10.7644 APE10-dist-na 7.0416 APE9-dist-in 4.7988 None None None XRAY 1.4 0.229 0.251 A 309.0 288.0 21 30 24 6 [[472, 750]] 1.0 9kfu Homo sapiens TYR_FGFR3_HUMAN TYR 1.7e-104 354.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 6PNXA P22607 456 757 806.0 ACP:801 ATPlike Inactive DFGin 5.1832 13.2568 BLAplus -117.43, 165.96 59.53, 36.21 -90.35, -22.61 56.49, 88.29 -100.71, 20.75 in-out in 7.758 Saltbr-out 3.8922 HRD-in -72.74, -43.96 72.66, -12.59 out-out-out SNCooo out-out ActLoopNT-out 8.6112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 61.32, -168.18 APE9-dihe-in -95.45, 138.6 APE8-dihe-in -83.08, 62.92 APE8-rot-na 32.84 APE67-dihe-in -77.59, -4.01 -63.19, -31.79 APE12-dist-na 17.76 APE11-dist-na 14.3869 APE10-dist-na 16.4747 APE9-dist-in 7.9796 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 A 324.0 291.0 11 30 30 0 [[472, 750]] 1.0 6pnx Homo sapiens TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 6PNXB P22607 455 756 806.0 ACP:801 ATPlike Inactive DFGin 5.1024 12.8796 BLAplus -116.22, 163.18 57.59, 45.48 -96.33, -11.84 56.51, 88.18 -107.89, 22.55 in-in in 7.3718 Saltbr-in 2.3809 HRD-in -94.02, -38.66 69.29, -17.12 in-out-out SNCioo out-out ActLoopNT-out 4.1485 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 54.33, 74.29 APE9-dihe-in -157.39, 146.53 APE8-dihe-in -79.85, 92.16 APE8-rot-na 29.38 APE67-dihe-in -64.97, -14.94 -62.55, -40.44 APE12-dist-na 17.5294 APE11-dist-na 16.9582 APE10-dist-na 14.6317 APE9-dist-in 7.491 C482A,C582S,R669E None None XRAY 2.199 0.195 0.23 B 324.0 294.0 8 30 30 0 [[472, 750]] 1.0 6pnx Homo sapiens TYR_FGFR3_HUMAN TYR 2.5e-104 354.1 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 8UDTA P22607 457 756 806.0 MLT:61001,MLT:61002,WGF:61003 Allosteric,Allosteric,Type1.5_Front Inactive DFGin 5.4408 13.493 BLAplus -114.8, 158.79 55.69, 43.2 -82.19, -34.37 42.84, 89.08 -83.27, -4.41 in-out in 8.3828 Saltbr-out 5.2872 HRD-in -68.34, -46.54 75.89, -9.4 out-out-out SNCooo out-out ActLoopNT-out 7.9211 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.29 APE8-dihe-out -63.06, -32.23 APE8-rot-na 340.92 APE67-dihe-in -68.35, -26.42 -62.13, -28.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.1982 P572S,P573G None None XRAY 2.829 0.263 0.274 A 297.0 284.0 4 30 26 4 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 9D1XA P22607 461 754 806.0 A1A6M:2001 Type1 Inactive DFGin 5.1196 12.6323 BLAplus -108.03, 159.86 61.02, 36.65 -81.76, -20.43 56.47, 81.47 -95.6, 7.99 in-in in 7.8726 Saltbr-in 3.0881 HRD-in -69.72, -49.85 77.77, -9.05 in-out-out SNCioo out-out ActLoopNT-out 7.4139 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -149.56, 157.12 APE9-dihe-in -112.69, 98.2 APE8-dihe-out -58.57, -23.42 APE8-rot-na 337.44 APE67-dihe-in -70.39, -9.82 -57.35, -25.35 APE12-dist-na 16.0046 APE11-dist-na 20.0862 APE10-dist-na 17.5026 APE9-dist-out 11.3051 P572S,P573G None None XRAY 1.6 0.18 0.19 A 297.0 282.0 0 30 30 0 [[472, 750]] 1.0 9d1x Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 9CD7A P22607 451 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.0186 12.7277 BLAplus -114.49, 161.16 51.06, 50.03 -90.62, -20.91 50.11, 84.08 -82.82, 141.47 in-in in 7.0948 Saltbr-in 2.5832 HRD-in -75.51, -51.62 85.64, -15.78 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 85.15 APE8-dihe-out -64.87, -3.22 APE8-rot-na 28.88 APE67-dihe-in -77.21, -9.06 -69.64, -25.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.3457 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 A 312.0 276.0 29 30 13 17 [[472, 750]] 1.0 9cd7 Homo sapiens TYR_FGFR3_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 9CD7B P22607 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.0653 12.8593 BLAplus -114.57, 159.12 51.43, 51.5 -92.22, -19.36 49.89, 84.09 -76.73, -39.85 in-in in 7.4133 Saltbr-in 2.5967 HRD-in -74.94, -51.38 85.94, -16.13 in-out-out SNCioo out-out ActLoopNT-out 7.5988 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.12 APE8-dihe-out -65.12, -2.8 APE8-rot-na 29.36 APE67-dihe-in -77.72, -8.63 -66.93, -28.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2175 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 B 312.0 278.0 20 30 24 6 [[472, 750]] 1.0 9cd7 Homo sapiens TYR_FGFR3_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 9CD7C P22607 458 755 806.0 A1AV2:801 Type1 Inactive DFGin 5.0552 12.9174 BLAplus -113.11, 157.29 52.27, 52.26 -91.9, -19.06 50.44, 84.08 -76.91, -39.15 in-in in 7.4207 Saltbr-in 2.6017 HRD-in -75.28, -51.41 85.96, -15.25 in-out-out SNCioo out-out ActLoopNT-out 7.7116 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.75 APE8-dihe-out -72.0, 23.1 APE8-rot-na 34.26 APE67-dihe-in -76.94, -9.16 -66.89, -26.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.796 C482A,C582S,K650E None None XRAY 2.53 0.23 0.267 C 312.0 278.0 20 30 24 6 [[472, 750]] 1.0 9cd7 Homo sapiens TYR_FGFR3_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 8UDVA P22607 458 755 806.0 WIQ:1003 Type1.5_Back Inactive DFGin 6.0012 13.4764 BLAplus -124.26, 161.29 66.5, 36.68 -91.33, -43.75 46.96, 90.73 -84.73, 13.25 in-in in 7.6609 Saltbr-in 2.9402 HRD-in -66.26, -46.33 75.0, -11.55 in-out-out SNCioo out-out ActLoopNT-out 8.16 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -144.63, 151.27 APE9-dihe-in -107.88, 92.32 APE8-dihe-out -54.6, -21.22 APE8-rot-na 338.66 APE67-dihe-in -68.84, -8.83 -57.22, -29.15 APE12-dist-na 15.9556 APE11-dist-na 19.9983 APE10-dist-na 17.2851 APE9-dist-out 11.6116 V555M None None XRAY 2.348 0.237 0.261 A 297.0 279.0 7 30 23 7 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 8UDVB P22607 455 755 806.0 WIQ:803 Type1.5_Back Inactive DFGin 5.4813 13.2542 BLAplus -124.6, 164.38 63.05, 27.71 -82.13, -38.21 55.85, 89.15 -91.32, 13.57 in-in in 7.68 Saltbr-in 2.9036 HRD-in -63.59, -46.44 79.4, -13.95 in-out-out SNCioo out-out ActLoopNT-out 8.9067 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -136.87, 152.88 APE9-dihe-in -110.79, 96.93 APE8-dihe-out -58.89, -20.81 APE8-rot-na 338.74 APE67-dihe-in -70.46, -8.74 -52.69, -32.19 APE12-dist-na 15.4794 APE11-dist-na 19.3858 APE10-dist-na 16.7032 APE9-dist-out 11.4241 V555M None None XRAY 2.348 0.237 0.261 B 297.0 281.0 8 30 22 8 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 8UDVC P22607 458 755 806.0 WIQ:1004 Type1.5_Back Inactive DFGin 6.071 13.4313 BLAplus -124.65, 164.21 70.39, 38.16 -109.8, -21.91 57.41, 87.59 -78.9, -34.05 in-in in 7.6549 Saltbr-in 2.8879 HRD-in -64.72, -49.48 77.07, -10.54 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 91.25 APE8-dihe-out -54.32, -20.59 APE8-rot-na 338.75 APE67-dihe-in -71.87, -8.91 -59.36, -26.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.6264 V555M None None XRAY 2.348 0.237 0.261 C 297.0 269.0 17 30 14 16 [[472, 750]] 1.0 8udv Homo sapiens TYR_FGFR3_HUMAN TYR 4.5e-105 356.6 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 8UDTB P22607 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.2581 13.7103 BLAplus -108.64, 157.87 56.15, 40.62 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.4451 Saltbr-out 5.3977 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.8672 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.6665 APE9-dist-out 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297.0 283.0 3 30 27 3 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 8UDTC P22607 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.2583 13.8238 BLAplus -109.74, 157.08 55.91, 40.67 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.1026 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.8702 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.4047 APE9-dist-out 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297.0 284.0 4 30 26 4 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
FGFR3 FGFR3_HUMAN 8UDUA P22607 460 756 806.0 WIQ:61002 Type1.5_Back Inactive DFGin 5.7614 13.5292 BLBplus -121.3, 171.32 71.72, 21.7 -99.77, 166.76 66.11, 93.34 95.58, -59.45 in-in in 7.9172 Saltbr-in 2.7343 HRD-in -77.2, -48.45 77.61, -12.83 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.65, 162.44 APE9-dihe-in -54.1, 129.25 APE8-dihe-in -83.64, 61.19 APE8-rot-na 34.62 APE67-dihe-in -73.43, -8.03 -52.16, -35.97 APE12-dist-na 999.0 APE11-dist-na 14.2323 APE10-dist-na 17.7469 APE9-dist-out 8.253 P572S,P573G None None XRAY 1.737 0.231 0.256 A 297.0 277.0 8 30 22 8 [[472, 750]] 1.0 8udu Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3

TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name