OTHER_EIF2AK4-2 (eIF-2-alpha kinase GCN2)

Total number of chains: 18
Active chains: 2
Uniprot: E2AK4_HUMAN
Kinase Domain Residues: 590 - 1001
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 8 44.4% 7QWKD
DFGin BLAminus 4 22.2% AF-Q9P2K8-K2A
DFGin None 4 22.2% 7QQ6B
DFGinter BABtrans 1 5.6% 7QWKH
DFGinter None 1 5.6% 7QWKF
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q9P2K8-K2A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 582 - 1009 0 None None eIF-2-alpha kinase GCN2
AF-Q9P2K8-K4A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 582 - 1009 0 None None eIF-2-alpha kinase GCN2
6N3NA 3.01 Inactive DFGin‑BLAminus out-out out-none nonTYR APEdihe_aanai APEdist_nnnn KA4 Type1 584 - 1003 0 None K807A,D848N,T899E,T904E eIF-2-alpha kinase GCN2
6N3OA 2.4 Inactive DFGin‑BLAminus out-out out-none nonTYR APEdihe_aanai APEdist_nnnn KA7 Type1.5_Back 584 - 1004 0 None K807A,D848N,T899E,T904E eIF-2-alpha kinase GCN2
7QQ6A 2.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 38O Type1 584 - 1004 0 None D848N eIF-2-alpha kinase GCN2
7QQ6B 2.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_oooo 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2
7QQ6C 2.8 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_nnno 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2
7QQ6D 2.8 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2
7QWKH 2.3 Inactive DFGinter‑BABtrans out-out out-out nonTYR APEdihe_aaoni APEdist_oooo G41 Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2
7QWKF 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoni APEdist_oooo G41 Type1 584 - 1005 0 None D848N eIF-2-alpha kinase GCN2
7QWKA 2.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 998 0 None D848N eIF-2-alpha kinase GCN2
7QWKB 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 998 0 None D848N eIF-2-alpha kinase GCN2
7QWKC 2.3 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aanni APEdist_nnnn G41 Type1 583 - 1004 0 None D848N eIF-2-alpha kinase GCN2
7QWKD 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 1003 0 None D848N eIF-2-alpha kinase GCN2
7QWKE 2.3 Inactive DFGout‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn G41 Type1 584 - 1004 0 None D848N eIF-2-alpha kinase GCN2
7QWKG 2.3 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aanni APEdist_nnnn G41 Type1 584 - 1007 0 None D848N eIF-2-alpha kinase GCN2
6N3LA 2.61 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn KAV Type2 584 - 1002 0 None K807A,D848N,T899A,T904A eIF-2-alpha kinase GCN2
6N3LB 2.61 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn KAV Type2 584 - 1002 0 None K807A,D848N,T899A,T904A eIF-2-alpha kinase GCN2

OTHER_EIF2AK4-2 (eIF-2-alpha kinase GCN2)

Total number of chains: 18
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 8 44.4% 7QWKD
DFGin BLAminus 4 22.2% AF-Q9P2K8-K2A
DFGin None 4 22.2% 7QQ6B
DFGinter BABtrans 1 5.6% 7QWKH
DFGinter None 1 5.6% 7QWKF
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
E2AK4_HUMAN AF-Q9P2K8-K2A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 582 - 1009 0 None None eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN AF-Q9P2K8-K4A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 582 - 1009 0 None None eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 6N3NA 3.01 Inactive DFGin‑BLAminus out-out out-none nonTYR APEdihe_aanai APEdist_nnnn KA4 Type1 584 - 1003 0 None K807A,D848N,T899E,T904E eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 6N3OA 2.4 Inactive DFGin‑BLAminus out-out out-none nonTYR APEdihe_aanai APEdist_nnnn KA7 Type1.5_Back 584 - 1004 0 None K807A,D848N,T899E,T904E eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QQ6A 2.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 38O Type1 584 - 1004 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QQ6B 2.8 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaooi APEdist_oooo 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QQ6C 2.8 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_nnno 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QQ6D 2.8 Inactive DFGin‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 38O Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QWKH 2.3 Inactive DFGinter‑BABtrans out-out out-out nonTYR APEdihe_aaoni APEdist_oooo G41 Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QWKF 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoni APEdist_oooo G41 Type1 584 - 1005 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QWKA 2.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 998 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QWKB 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 998 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QWKC 2.3 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aanni APEdist_nnnn G41 Type1 583 - 1004 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QWKD 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 1003 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QWKE 2.3 Inactive DFGout‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn G41 Type1 584 - 1004 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 7QWKG 2.3 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aanni APEdist_nnnn G41 Type1 584 - 1007 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 6N3LA 2.61 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn KAV Type2 584 - 1002 0 None K807A,D848N,T899A,T904A eIF-2-alpha kinase GCN2 Homo sapiens
E2AK4_HUMAN 6N3LB 2.61 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn KAV Type2 584 - 1002 0 None K807A,D848N,T899A,T904A eIF-2-alpha kinase GCN2 Homo sapiens

OTHER_EIF2AK4-2 (eIF-2-alpha kinase GCN2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism