OTHER_EIF2AK4-2 (eIF-2-alpha kinase GCN2)

Total number of chains: 18
Active chains: 2
Uniprot: E2AK4_HUMAN
Kinase Domain Residues: 590 - 1001
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 8 44.4% 7QWKD
DFGin BLAminus 4 22.2% AF-Q9P2K8-K2A
DFGin None 4 22.2% 7QQ6B
DFGinter BABtrans 1 5.6% 7QWKH
DFGinter None 1 5.6% 7QWKF
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EIF2AK4-2 AF-Q9P2K8-K2A Q9P2K8 582 1009 1649.0 No_ligand No_ligand Active DFGin 6.617 14.3334 BLAminus -136.29, -175.54 55.03, 79.43 -90.03, 22.0 290.92, 79.21 -58.96, -26.48 in-in in 9.5056 Saltbr-in 2.9486 HRD-in -71.79, -47.78 64.97, -9.83 in-in-in SNCiii in-in ActLoopNT-in 3.0125 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.06, 154.72 APE9-dihe-na 104.42, 174.21 APE8-dihe-in -78.42, 122.57 APE8-rot-in 303.04 APE67-dihe-in -70.42, -29.98 -45.44, -33.85 APE12-dist-in 11.1201 APE11-dist-in 11.8919 APE10-dist-in 5.9185 APE9-dist-in 3.7355 None None None AF2 -1.0 1.0 1.0 A 428.0 428.0 0 46 46 0 [[277, 541], [590, 1001]] 2.0 AF-Q9P2K8-K2 OTHER_EIF2AK4-2_HUMAN OTHER 1.4e-46 165.1 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 AF-Q9P2K8-K4A Q9P2K8 582 1009 1649.0 No_ligand No_ligand Active DFGin 6.6056 13.9985 BLAminus -136.5, -169.45 54.98, 63.3 -76.1, 15.72 292.56, 86.18 -62.07, -22.72 in-in in 8.8076 Saltbr-in 2.7462 HRD-in -75.42, -42.82 64.6, -12.86 in-in-in SNCiii in-in ActLoopNT-in 2.9019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.36, 139.51 APE9-dihe-na 113.38, 169.46 APE8-dihe-in -72.14, 130.61 APE8-rot-in 295.69 APE67-dihe-in -77.95, -5.75 -49.91, -35.42 APE12-dist-in 11.0678 APE11-dist-in 11.9312 APE10-dist-in 6.1496 APE9-dist-in 3.3593 None None None AF2 -1.0 1.0 1.0 A 428.0 428.0 0 46 46 0 [[277, 541], [590, 1001]] 2.0 AF-Q9P2K8-K4 OTHER_EIF2AK4-2_HUMAN OTHER 1.4e-46 165.1 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 6N3NA Q9P2K8 584 1003 1649.0 KA4:62500 Type1 Inactive DFGin 6.9419 14.8962 BLAminus -161.77, -164.95 51.61, 53.4 -59.48, -46.57 276.83, 65.68 113.21, 101.52 out-out out 11.8329 Saltbr-out 11.4985 HRD-in -82.81, -56.02 77.87, -40.32 out-out-none SNCoon out-none ActLoopNT-out 8.5281 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 6.58 APE8-rot-na 302.93 APE67-dihe-in -70.39, -29.28 -70.81, -30.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899E,T904E None None XRAY 3.01 0.219 0.277 A 317.0 242.0 55 46 19 27 [[277, 541], [590, 1001]] 2.0 6n3n OTHER_EIF2AK4-2_HUMAN OTHER 2.4e-45 161.1 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 6N3OA Q9P2K8 584 1004 1649.0 KA7:62500 Type1.5_Back Inactive DFGin 6.6523 15.2081 BLAminus -153.67, -168.18 56.94, 54.84 -57.06, -41.03 283.3, 70.25 96.81, 112.56 out-out out 12.2274 Saltbr-out 12.5811 HRD-in -73.69, -58.26 76.04, -15.13 out-out-none SNCoon out-none ActLoopNT-out 8.6582 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.04 APE8-rot-na 294.34 APE67-dihe-in -83.15, -13.22 -77.59, -5.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899E,T904E None None XRAY 2.4 0.202 0.254 A 317.0 252.0 46 46 20 26 [[277, 541], [590, 1001]] 2.0 6n3o OTHER_EIF2AK4-2_HUMAN OTHER 2.4e-45 161.1 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QQ6A Q9P2K8 584 1004 1649.0 38O:1701 Type1 Inactive DFGin 4.5453 13.8322 None -64.42, 179.79 -78.36, -177.52 -104.81, 135.74 11.85, 74.61 -87.56, 999.0 out-out out 10.4039 Saltbr-out 7.2276 HRD-in -78.55, -45.81 67.95, -11.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -139.37, 156.89 APE9-dihe-na 68.88, -136.49 APE8-dihe-out -63.0, -22.3 APE8-rot-out 54.98 APE67-dihe-in -64.33, -22.31 -64.88, -30.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3092 D848N None None XRAY 2.8 0.213 0.258 A 320.0 269.0 26 46 26 20 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QQ6B Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.7434 14.4365 None -62.22, 177.25 -71.17, -177.31 -113.77, 112.84 16.57, 83.07 -117.04, 75.83 out-out out 10.6295 Saltbr-out 6.7733 HRD-in -73.84, -58.14 68.49, 11.03 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -145.51, 135.89 APE9-dihe-na 67.14, -114.96 APE8-dihe-out -68.69, -35.73 APE8-rot-out 40.19 APE67-dihe-in -61.7, -18.1 -60.4, -26.4 APE12-dist-out 22.8084 APE11-dist-out 18.7912 APE10-dist-out 18.981 APE9-dist-out 12.6461 D848N None None XRAY 2.8 0.213 0.258 B 320.0 275.0 22 46 28 18 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QQ6C Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 5.1533 15.3312 None -67.88, 178.26 -74.84, 168.69 -62.36, -56.97 309.72, 121.46 57.54, 31.05 out-out out 10.4307 Saltbr-out 6.7866 HRD-in -71.08, -48.65 67.11, -5.82 out-out-out SNCooo out-out ActLoopNT-out 7.7299 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 103.35 APE8-dihe-out -115.25, -20.91 APE8-rot-out 51.72 APE67-dihe-in -84.71, -19.81 -111.62, 33.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7921 D848N None None XRAY 2.8 0.213 0.258 C 320.0 267.0 30 46 17 29 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QQ6D Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.7934 14.7823 None -71.0, 172.41 -73.73, 163.04 -66.19, -82.98 327.33, 91.13 74.54, 67.6 out-out out 11.1023 Saltbr-out 6.778 HRD-in -68.97, -46.58 79.03, -46.68 out-out-none SNCoon out-none ActLoopNT-out 6.5052 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.25, -17.58 999.0, -55.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.8 0.213 0.258 D 320.0 260.0 37 46 17 29 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QWKH Q9P2K8 584 1006 1649.0 G41:1701 Type1 Inactive DFGinter 8.0462 8.4367 BABtrans -55.61, 130.2 -124.52, 16.67 -106.93, 111.28 188.62, 73.34 126.77, 18.12 out-out out 11.0562 Saltbr-out 7.6256 HRD-in -81.65, -56.1 78.04, -22.14 out-out-out SNCooo out-out ActLoopNT-out 5.2947 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -63.36, -44.68 APE9-dihe-na -61.4, -37.94 APE8-dihe-out -73.72, -24.45 APE8-rot-none 999.0 APE67-dihe-in -74.17, -2.36 -79.69, -19.77 APE12-dist-out 22.3633 APE11-dist-out 21.0532 APE10-dist-out 23.9535 APE9-dist-out 13.5058 D848N None None XRAY 2.3 0.214 0.243 H 318.0 259.0 38 46 27 19 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QWKF Q9P2K8 584 1005 1649.0 G41:1701 Type1 Inactive DFGinter 8.0374 8.1815 None -60.18, 141.19 -134.64, 94.13 -155.09, 69.13 206.23, 33.34 148.0, 161.57 out-out out 11.1145 Saltbr-out 8.211 HRD-in -90.54, -49.57 66.47, -5.34 out-out-out SNCooo out-out ActLoopNT-out 6.628 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na 134.32, -54.28 APE9-dihe-na -62.87, -46.85 APE8-dihe-out -62.12, -35.02 APE8-rot-none 999.0 APE67-dihe-in -70.96, -4.61 -71.45, -20.51 APE12-dist-out 23.468 APE11-dist-out 21.7478 APE10-dist-out 24.3155 APE9-dist-out 13.581 D848N None None XRAY 2.3 0.214 0.243 F 318.0 254.0 42 46 22 24 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QWKA Q9P2K8 583 998 1649.0 G41:1701 Type1 Inactive DFGout 17.8239 9.5126 None -134.51, -151.1 -121.46, -46.25 35.17, 27.68 228.21, 155.53 -84.53, 128.11 out-none out 11.5577 Saltbr-none 999.0 HRD-in -76.45, -48.97 72.32, -6.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.65 APE8-dihe-out -87.38, 8.98 APE8-rot-none 999.0 APE67-dihe-in -67.63, -12.84 -66.2, 0.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2821 D848N None None XRAY 2.3 0.214 0.243 A 318.0 245.0 48 46 13 33 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QWKB Q9P2K8 583 998 1649.0 G41:1701 Type1 Inactive DFGout 17.8439 9.3903 None -144.52, -139.04 -156.42, 125.77 -114.71, 16.01 223.02, 149.14 -71.92, 114.82 out-out out 11.8481 Saltbr-out 8.1951 HRD-in -79.04, -54.75 67.92, 8.38 out-out-out SNCooo out-out ActLoopNT-out 14.5345 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.73 APE8-dihe-out -76.87, -29.31 APE8-rot-none 999.0 APE67-dihe-in -63.87, -23.61 -70.02, -18.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8685 D848N None None XRAY 2.3 0.214 0.243 B 318.0 249.0 44 46 20 26 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QWKC Q9P2K8 583 1004 1649.0 G41:1701 Type1 Inactive DFGout 17.9422 9.7212 None -140.22, -142.02 -158.37, 117.76 -96.27, -4.59 219.72, 151.65 -71.27, 106.76 out-out out 11.963 Saltbr-out 7.857 HRD-in -88.1, -52.43 58.54, 27.47 out-out-none SNCoon out-none ActLoopNT-out 15.3146 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -59.9 APE8-rot-none 999.0 APE67-dihe-in -67.01, -4.12 -84.11, -11.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 C 318.0 249.0 47 46 16 30 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QWKD Q9P2K8 583 1003 1649.0 G41:1701 Type1 Inactive DFGout 17.7026 9.3216 None -139.27, -135.78 -159.12, 124.73 -118.38, 23.17 221.49, 144.06 -75.45, 126.8 out-out out 11.8336 Saltbr-out 8.4313 HRD-in -88.04, -58.27 56.71, 45.95 out-out-out SNCooo out-out ActLoopNT-out 14.7493 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -86.87 APE8-dihe-out -67.23, -22.9 APE8-rot-none 999.0 APE67-dihe-in -74.1, -19.72 -68.07, -8.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.5566 D848N None None XRAY 2.3 0.214 0.243 D 318.0 254.0 41 46 19 27 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QWKE Q9P2K8 584 1004 1649.0 G41:1701 Type1 Inactive DFGout 17.7793 9.8216 None -151.76, -141.6 -160.26, 136.01 -98.22, 91.17 239.64, 115.15 -107.96, 84.44 out-none out 11.0819 Saltbr-none 999.0 HRD-in -88.02, -51.01 74.43, -13.48 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 E 318.0 241.0 54 46 4 42 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 7QWKG Q9P2K8 584 1007 1649.0 G41:1701 Type1 Inactive DFGout 18.1915 10.1344 None -152.52, -143.94 -140.15, -46.73 82.87, -54.7 218.3, 133.54 -74.32, 999.0 out-out out 11.6583 Saltbr-out 9.1998 HRD-in -81.42, -58.02 87.03, -25.33 out-out-none SNCoon out-none ActLoopNT-out 6.6179 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -52.87 APE8-rot-none 999.0 APE67-dihe-in -65.85, -22.5 -65.49, -20.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 G 318.0 257.0 41 46 20 26 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 6N3LA Q9P2K8 584 1002 1649.0 KAV:62501 Type2 Inactive DFGout 15.7238 8.6945 None -131.92, -171.74 -165.1, 131.81 -91.39, 999.0 282.47, 16.23 999.0, 999.0 in-in in 8.3752 Saltbr-in 3.222 HRD-in -61.96, -55.14 81.8, -15.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -34.98 APE8-rot-none 999.0 APE67-dihe-in -81.86, -12.43 -63.68, -11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899A,T904A None None XRAY 2.61 0.226 0.29 A 330.0 230.0 65 46 10 36 [[277, 541], [590, 1001]] 2.0 6n3l OTHER_EIF2AK4-2_HUMAN OTHER 3.8e-45 160.5 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 6N3LB Q9P2K8 584 1002 1649.0 KAV:62501 Type2 Inactive DFGout 15.4447 8.6193 None -134.73, -168.42 -167.35, 133.28 -92.51, 999.0 285.34, 13.72 999.0, 999.0 in-in in 8.3883 Saltbr-in 3.4825 HRD-in -61.97, -53.58 83.5, -20.28 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.86 APE8-rot-none 999.0 APE67-dihe-in -82.56, -10.84 -61.36, -8.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899A,T904A None None XRAY 2.61 0.226 0.29 B 330.0 227.0 68 46 10 36 [[277, 541], [590, 1001]] 2.0 6n3l OTHER_EIF2AK4-2_HUMAN OTHER 3.8e-45 160.5 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2

OTHER_EIF2AK4-2 (eIF-2-alpha kinase GCN2)

Total number of chains: 18
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 8 44.4% 7QWKD
DFGin BLAminus 4 22.2% AF-Q9P2K8-K2A
DFGin None 4 22.2% 7QQ6B
DFGinter BABtrans 1 5.6% 7QWKH
DFGinter None 1 5.6% 7QWKF
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EIF2AK4-2 E2AK4_HUMAN AF-Q9P2K8-K2A Q9P2K8 582 1009 1649.0 No_ligand No_ligand Active DFGin 6.617 14.3334 BLAminus -136.29, -175.54 55.03, 79.43 -90.03, 22.0 290.92, 79.21 -58.96, -26.48 in-in in 9.5056 Saltbr-in 2.9486 HRD-in -71.79, -47.78 64.97, -9.83 in-in-in SNCiii in-in ActLoopNT-in 3.0125 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.06, 154.72 APE9-dihe-na 104.42, 174.21 APE8-dihe-in -78.42, 122.57 APE8-rot-in 303.04 APE67-dihe-in -70.42, -29.98 -45.44, -33.85 APE12-dist-in 11.1201 APE11-dist-in 11.8919 APE10-dist-in 5.9185 APE9-dist-in 3.7355 None None None AF2 -1.0 1.0 1.0 A 428.0 428.0 0 46 46 0 [[277, 541], [590, 1001]] 2.0 AF-Q9P2K8-K2 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 1.4e-46 165.1 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN AF-Q9P2K8-K4A Q9P2K8 582 1009 1649.0 No_ligand No_ligand Active DFGin 6.6056 13.9985 BLAminus -136.5, -169.45 54.98, 63.3 -76.1, 15.72 292.56, 86.18 -62.07, -22.72 in-in in 8.8076 Saltbr-in 2.7462 HRD-in -75.42, -42.82 64.6, -12.86 in-in-in SNCiii in-in ActLoopNT-in 2.9019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.36, 139.51 APE9-dihe-na 113.38, 169.46 APE8-dihe-in -72.14, 130.61 APE8-rot-in 295.69 APE67-dihe-in -77.95, -5.75 -49.91, -35.42 APE12-dist-in 11.0678 APE11-dist-in 11.9312 APE10-dist-in 6.1496 APE9-dist-in 3.3593 None None None AF2 -1.0 1.0 1.0 A 428.0 428.0 0 46 46 0 [[277, 541], [590, 1001]] 2.0 AF-Q9P2K8-K4 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 1.4e-46 165.1 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 6N3NA Q9P2K8 584 1003 1649.0 KA4:62500 Type1 Inactive DFGin 6.9419 14.8962 BLAminus -161.77, -164.95 51.61, 53.4 -59.48, -46.57 276.83, 65.68 113.21, 101.52 out-out out 11.8329 Saltbr-out 11.4985 HRD-in -82.81, -56.02 77.87, -40.32 out-out-none SNCoon out-none ActLoopNT-out 8.5281 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 6.58 APE8-rot-na 302.93 APE67-dihe-in -70.39, -29.28 -70.81, -30.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899E,T904E None None XRAY 3.01 0.219 0.277 A 317.0 242.0 55 46 19 27 [[277, 541], [590, 1001]] 2.0 6n3n Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.4e-45 161.1 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 6N3OA Q9P2K8 584 1004 1649.0 KA7:62500 Type1.5_Back Inactive DFGin 6.6523 15.2081 BLAminus -153.67, -168.18 56.94, 54.84 -57.06, -41.03 283.3, 70.25 96.81, 112.56 out-out out 12.2274 Saltbr-out 12.5811 HRD-in -73.69, -58.26 76.04, -15.13 out-out-none SNCoon out-none ActLoopNT-out 8.6582 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.04 APE8-rot-na 294.34 APE67-dihe-in -83.15, -13.22 -77.59, -5.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899E,T904E None None XRAY 2.4 0.202 0.254 A 317.0 252.0 46 46 20 26 [[277, 541], [590, 1001]] 2.0 6n3o Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.4e-45 161.1 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QQ6A Q9P2K8 584 1004 1649.0 38O:1701 Type1 Inactive DFGin 4.5453 13.8322 None -64.42, 179.79 -78.36, -177.52 -104.81, 135.74 11.85, 74.61 -87.56, 999.0 out-out out 10.4039 Saltbr-out 7.2276 HRD-in -78.55, -45.81 67.95, -11.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -139.37, 156.89 APE9-dihe-na 68.88, -136.49 APE8-dihe-out -63.0, -22.3 APE8-rot-out 54.98 APE67-dihe-in -64.33, -22.31 -64.88, -30.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3092 D848N None None XRAY 2.8 0.213 0.258 A 320.0 269.0 26 46 26 20 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QQ6B Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.7434 14.4365 None -62.22, 177.25 -71.17, -177.31 -113.77, 112.84 16.57, 83.07 -117.04, 75.83 out-out out 10.6295 Saltbr-out 6.7733 HRD-in -73.84, -58.14 68.49, 11.03 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -145.51, 135.89 APE9-dihe-na 67.14, -114.96 APE8-dihe-out -68.69, -35.73 APE8-rot-out 40.19 APE67-dihe-in -61.7, -18.1 -60.4, -26.4 APE12-dist-out 22.8084 APE11-dist-out 18.7912 APE10-dist-out 18.981 APE9-dist-out 12.6461 D848N None None XRAY 2.8 0.213 0.258 B 320.0 275.0 22 46 28 18 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QQ6C Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 5.1533 15.3312 None -67.88, 178.26 -74.84, 168.69 -62.36, -56.97 309.72, 121.46 57.54, 31.05 out-out out 10.4307 Saltbr-out 6.7866 HRD-in -71.08, -48.65 67.11, -5.82 out-out-out SNCooo out-out ActLoopNT-out 7.7299 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 103.35 APE8-dihe-out -115.25, -20.91 APE8-rot-out 51.72 APE67-dihe-in -84.71, -19.81 -111.62, 33.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7921 D848N None None XRAY 2.8 0.213 0.258 C 320.0 267.0 30 46 17 29 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QQ6D Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.7934 14.7823 None -71.0, 172.41 -73.73, 163.04 -66.19, -82.98 327.33, 91.13 74.54, 67.6 out-out out 11.1023 Saltbr-out 6.778 HRD-in -68.97, -46.58 79.03, -46.68 out-out-none SNCoon out-none ActLoopNT-out 6.5052 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.25, -17.58 999.0, -55.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.8 0.213 0.258 D 320.0 260.0 37 46 17 29 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QWKH Q9P2K8 584 1006 1649.0 G41:1701 Type1 Inactive DFGinter 8.0462 8.4367 BABtrans -55.61, 130.2 -124.52, 16.67 -106.93, 111.28 188.62, 73.34 126.77, 18.12 out-out out 11.0562 Saltbr-out 7.6256 HRD-in -81.65, -56.1 78.04, -22.14 out-out-out SNCooo out-out ActLoopNT-out 5.2947 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -63.36, -44.68 APE9-dihe-na -61.4, -37.94 APE8-dihe-out -73.72, -24.45 APE8-rot-none 999.0 APE67-dihe-in -74.17, -2.36 -79.69, -19.77 APE12-dist-out 22.3633 APE11-dist-out 21.0532 APE10-dist-out 23.9535 APE9-dist-out 13.5058 D848N None None XRAY 2.3 0.214 0.243 H 318.0 259.0 38 46 27 19 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QWKF Q9P2K8 584 1005 1649.0 G41:1701 Type1 Inactive DFGinter 8.0374 8.1815 None -60.18, 141.19 -134.64, 94.13 -155.09, 69.13 206.23, 33.34 148.0, 161.57 out-out out 11.1145 Saltbr-out 8.211 HRD-in -90.54, -49.57 66.47, -5.34 out-out-out SNCooo out-out ActLoopNT-out 6.628 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na 134.32, -54.28 APE9-dihe-na -62.87, -46.85 APE8-dihe-out -62.12, -35.02 APE8-rot-none 999.0 APE67-dihe-in -70.96, -4.61 -71.45, -20.51 APE12-dist-out 23.468 APE11-dist-out 21.7478 APE10-dist-out 24.3155 APE9-dist-out 13.581 D848N None None XRAY 2.3 0.214 0.243 F 318.0 254.0 42 46 22 24 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QWKA Q9P2K8 583 998 1649.0 G41:1701 Type1 Inactive DFGout 17.8239 9.5126 None -134.51, -151.1 -121.46, -46.25 35.17, 27.68 228.21, 155.53 -84.53, 128.11 out-none out 11.5577 Saltbr-none 999.0 HRD-in -76.45, -48.97 72.32, -6.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.65 APE8-dihe-out -87.38, 8.98 APE8-rot-none 999.0 APE67-dihe-in -67.63, -12.84 -66.2, 0.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2821 D848N None None XRAY 2.3 0.214 0.243 A 318.0 245.0 48 46 13 33 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QWKB Q9P2K8 583 998 1649.0 G41:1701 Type1 Inactive DFGout 17.8439 9.3903 None -144.52, -139.04 -156.42, 125.77 -114.71, 16.01 223.02, 149.14 -71.92, 114.82 out-out out 11.8481 Saltbr-out 8.1951 HRD-in -79.04, -54.75 67.92, 8.38 out-out-out SNCooo out-out ActLoopNT-out 14.5345 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.73 APE8-dihe-out -76.87, -29.31 APE8-rot-none 999.0 APE67-dihe-in -63.87, -23.61 -70.02, -18.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8685 D848N None None XRAY 2.3 0.214 0.243 B 318.0 249.0 44 46 20 26 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QWKC Q9P2K8 583 1004 1649.0 G41:1701 Type1 Inactive DFGout 17.9422 9.7212 None -140.22, -142.02 -158.37, 117.76 -96.27, -4.59 219.72, 151.65 -71.27, 106.76 out-out out 11.963 Saltbr-out 7.857 HRD-in -88.1, -52.43 58.54, 27.47 out-out-none SNCoon out-none ActLoopNT-out 15.3146 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -59.9 APE8-rot-none 999.0 APE67-dihe-in -67.01, -4.12 -84.11, -11.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 C 318.0 249.0 47 46 16 30 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QWKD Q9P2K8 583 1003 1649.0 G41:1701 Type1 Inactive DFGout 17.7026 9.3216 None -139.27, -135.78 -159.12, 124.73 -118.38, 23.17 221.49, 144.06 -75.45, 126.8 out-out out 11.8336 Saltbr-out 8.4313 HRD-in -88.04, -58.27 56.71, 45.95 out-out-out SNCooo out-out ActLoopNT-out 14.7493 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -86.87 APE8-dihe-out -67.23, -22.9 APE8-rot-none 999.0 APE67-dihe-in -74.1, -19.72 -68.07, -8.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.5566 D848N None None XRAY 2.3 0.214 0.243 D 318.0 254.0 41 46 19 27 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QWKE Q9P2K8 584 1004 1649.0 G41:1701 Type1 Inactive DFGout 17.7793 9.8216 None -151.76, -141.6 -160.26, 136.01 -98.22, 91.17 239.64, 115.15 -107.96, 84.44 out-none out 11.0819 Saltbr-none 999.0 HRD-in -88.02, -51.01 74.43, -13.48 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 E 318.0 241.0 54 46 4 42 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 7QWKG Q9P2K8 584 1007 1649.0 G41:1701 Type1 Inactive DFGout 18.1915 10.1344 None -152.52, -143.94 -140.15, -46.73 82.87, -54.7 218.3, 133.54 -74.32, 999.0 out-out out 11.6583 Saltbr-out 9.1998 HRD-in -81.42, -58.02 87.03, -25.33 out-out-none SNCoon out-none ActLoopNT-out 6.6179 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -52.87 APE8-rot-none 999.0 APE67-dihe-in -65.85, -22.5 -65.49, -20.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 G 318.0 257.0 41 46 20 26 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 6N3LA Q9P2K8 584 1002 1649.0 KAV:62501 Type2 Inactive DFGout 15.7238 8.6945 None -131.92, -171.74 -165.1, 131.81 -91.39, 999.0 282.47, 16.23 999.0, 999.0 in-in in 8.3752 Saltbr-in 3.222 HRD-in -61.96, -55.14 81.8, -15.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -34.98 APE8-rot-none 999.0 APE67-dihe-in -81.86, -12.43 -63.68, -11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899A,T904A None None XRAY 2.61 0.226 0.29 A 330.0 230.0 65 46 10 36 [[277, 541], [590, 1001]] 2.0 6n3l Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 3.8e-45 160.5 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
EIF2AK4-2 E2AK4_HUMAN 6N3LB Q9P2K8 584 1002 1649.0 KAV:62501 Type2 Inactive DFGout 15.4447 8.6193 None -134.73, -168.42 -167.35, 133.28 -92.51, 999.0 285.34, 13.72 999.0, 999.0 in-in in 8.3883 Saltbr-in 3.4825 HRD-in -61.97, -53.58 83.5, -20.28 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.86 APE8-rot-none 999.0 APE67-dihe-in -82.56, -10.84 -61.36, -8.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899A,T904A None None XRAY 2.61 0.226 0.29 B 330.0 227.0 68 46 10 36 [[277, 541], [590, 1001]] 2.0 6n3l Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 3.8e-45 160.5 1.0 256.0 256.0 865 866 867 869 871 619 636 640 845 847 846 848.0 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2

OTHER_EIF2AK4-2 (eIF-2-alpha kinase GCN2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name