8TQW

CDK8 (Cyclin-dependent kinase 8)
Group: CMGC
Uniprot: CDK8_HUMAN
Organism: Homo sapiens
Domain boundary: 20 - 335
Resolu: 8.2

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
a Inactive DFGin BLAplus in-out in-in No_ligand No_ligand 1 - 359 0
Representative sequence - Chain a
10 20 30 40
MDYDFKVKLS SERERVEDLF EYEGCKVGRG TYGHVYKAKR
50 60 70 80
KdgkddkDYA LKQIEGTGIS MSACREIALL RELKHPNVIS
90 100 110 120
LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRaskankkp
130 140 150 160
vqLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM
170 180 190 200
GEGPERGRVK IADMGFARLF NSPLKPLADL DPVVVTFWYR
210 220 230 240
APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCrqed
250 260 270 280
iktsnpyhHD QLDRIFNVMG FPADkdwedi kkMPEHSTLM
290 300 310 320
kdfrrntytn CSLIKYMEKH KVKPDSKAFH LLQKLLTMDP
330 340 350 360
IKRITSEQAM QDPYFLEDPL PTSDVFAGCQ IPYPKREFLt
370 380 390 400
eeepddkgdk knqqqqqgnn htngtghpgn qdsshtqgpp
410 420 430 440
lkkvrvvppt ttsgglimts dyqrsnphaa ypnpgpstsq
450 460
pqssmgysat sqqppqyshq thry
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None