CMGC_CDK8 (Cyclin-dependent kinase 8)

Total number of chains: 38
Active chains: 2
Uniprot: CDK8_HUMAN
Kinase Domain Residues: 20 - 335
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 14 36.8% 6T41A
DFGin BLAminus 10 26.3% AF-P49336-K1A
DFGout BBAminus 9 23.7% 6TPAA
DFGin BLAplus 3 7.9% 8TQ2A
DFGin BLBplus 1 2.6% 5HBHA
None None 1 2.6% 4F70A

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK8 AF-P49336-K1A P49336 12 343 464.0 No_ligand No_ligand Active DFGin 6.9313 15.6629 BLAminus -128.17, 177.28 55.68, 59.43 -72.54, 15.56 300.04, 114.68 -62.04, -32.39 in-in in 9.1654 Saltbr-in 2.8975 HRD-in -73.5, -51.19 62.86, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.8327 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.05, 164.39 APE9-dihe-na 83.32, 124.4 APE8-dihe-in -52.27, 134.37 APE8-rot-in 287.61 APE67-dihe-in -65.17, -26.48 -44.23, -41.35 APE12-dist-in 12.0588 APE11-dist-in 11.607 APE10-dist-in 5.8083 APE9-dist-in 3.4091 None None None AF2 -1.0 1.0 1.0 A 332.0 332.0 0 31 31 0 [[22, 335]] 1.0 AF-P49336-K1 CMGC_CDK8_HUMAN CMGC 2.9e-82 282.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 AF-P49336-K3A P49336 12 343 464.0 No_ligand No_ligand Active DFGin 7.0585 14.4146 BLAminus -125.11, 179.05 58.06, 66.16 -75.42, 13.63 298.43, 116.53 -58.59, -38.0 in-in in 9.222 Saltbr-in 2.7201 HRD-in -77.81, -49.38 63.32, 9.66 in-in-in SNCiii in-in ActLoopNT-in 2.8729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.07, 166.88 APE9-dihe-na 60.71, 128.33 APE8-dihe-in -54.75, 135.42 APE8-rot-in 297.36 APE67-dihe-in -67.37, -15.46 -44.59, -50.0 APE12-dist-in 12.5614 APE11-dist-in 10.811 APE10-dist-in 6.5807 APE9-dist-in 3.286 None None None AF2 -1.0 1.0 1.0 A 332.0 332.0 0 31 31 0 [[22, 335]] 1.0 AF-P49336-K3 CMGC_CDK8_HUMAN CMGC 2.9e-82 282.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5HBJA P49336 1 361 464.0 5Y8:60401 Type1 Inactive DFGin 7.5418 14.7786 BLAminus -106.87, 176.98 71.07, 89.31 -114.96, 61.9 305.41, 118.79 -100.84, -170.16 in-in in 9.7609 Saltbr-in 2.6824 HRD-in -77.67, -52.92 73.2, 5.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -16.09 APE8-dihe-in -117.57, 98.85 APE8-rot-in 304.83 APE67-dihe-in -72.47, -22.93 -102.77, 29.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3779 None None None XRAY 3.0 999.0 0.288 A 364.0 340.0 21 31 19 12 [[22, 335]] 1.0 5hbj CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5ICPA P49336 1 362 464.0 69Z:60401 Type1 Inactive DFGin 6.1473 13.6394 BLAminus -129.39, 179.13 50.41, 56.76 -66.42, 4.81 256.2, 78.89 56.91, 53.37 in-in in 9.1898 Saltbr-in 2.5875 HRD-in -78.65, -54.95 77.97, -2.02 in-out-out SNCioo out-out ActLoopNT-out 8.7892 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 83.07 APE9-dihe-na -127.02, 140.47 APE8-dihe-in -112.3, 142.07 APE8-rot-out 57.72 APE67-dihe-in -65.52, -25.52 -110.98, 18.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.6843 APE9-dist-out 12.5091 None None None XRAY 2.18 0.185 0.216 A 364.0 343.0 19 31 23 8 [[22, 335]] 1.0 5icp CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5IDNA P49336 1 363 464.0 6A7:60401 Type1 Inactive DFGin 7.3226 16.0877 BLAminus -124.47, 174.0 67.51, 75.48 -91.55, 21.99 294.62, 123.1 -96.7, 0.53 in-in in 8.9702 Saltbr-in 2.647 HRD-in -71.0, -49.83 80.54, -0.94 in-out-out SNCioo out-out ActLoopNT-out 8.4045 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.78 APE8-dihe-in -125.68, 150.04 APE8-rot-out 46.55 APE67-dihe-in -67.71, -25.83 -125.87, 33.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7732 None None None XRAY 2.26 0.221 0.253 A 370.0 336.0 27 31 15 16 [[22, 335]] 1.0 5idn CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5XQXA P49336 1 362 464.0 8CC:60402 Type1 Inactive DFGin 7.1009 13.3766 BLAminus -124.76, 173.54 67.85, 87.06 -93.65, 13.06 285.44, 142.36 -53.92, -30.2 in-in in 8.5993 Saltbr-in 2.6458 HRD-in -76.07, -52.85 74.84, 2.4 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.45 APE8-dihe-in -121.89, 118.59 APE8-rot-in 276.05 APE67-dihe-in -59.33, -23.95 -109.46, 21.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0086 None None None XRAY 2.3 0.19 0.222 A 380.0 337.0 25 31 18 13 [[22, 335]] 1.0 5xqx CMGC_CDK8_HUMAN CMGC 4.7e-82 281.6 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5XS2A P49336 1 363 464.0 8D6:60402 Type1 Inactive DFGin 7.1 13.2185 BLAminus -125.86, 168.92 68.44, 89.08 -85.59, 13.7 295.46, 132.91 -57.29, -23.08 in-in in 8.5472 Saltbr-in 2.6849 HRD-in -77.09, -53.4 74.45, 0.97 in-in-out SNCiio in-out ActLoopNT-in 2.7249 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -119.34, 129.98 APE9-dihe-na -115.73, -15.25 APE8-dihe-in -128.4, 144.08 APE8-rot-out 53.94 APE67-dihe-in -59.75, -24.05 -125.87, 25.67 APE12-dist-in 7.1385 APE11-dist-in 11.8021 APE10-dist-out 9.8465 APE9-dist-out 12.3679 None None None XRAY 2.04 0.197 0.225 A 380.0 363.0 0 31 31 0 [[22, 335]] 1.0 5xs2 CMGC_CDK8_HUMAN CMGC 4.7e-82 281.6 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 6QTJA P49336 1 359 464.0 JHK:60501 Type1 Inactive DFGin 7.5864 14.0745 BLAminus -112.22, -179.25 62.71, 86.71 -102.98, 13.61 301.92, 111.63 -83.54, 3.25 in-in in 8.4612 Saltbr-in 2.9368 HRD-in -68.14, -49.62 76.51, -6.19 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.96 APE8-dihe-in -121.23, 128.93 APE8-rot-in 272.12 APE67-dihe-in -58.17, -25.47 -117.92, 17.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2357 None None None XRAY 2.48 0.187 0.22 A 405.0 329.0 30 31 13 18 [[22, 335]] 1.0 6qtj CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 9H8CA P49336 1 361 464.0 A1IS8:60503 Type1 Inactive DFGin 7.5455 14.2354 BLAminus -123.76, 163.44 68.83, 82.68 -94.14, 12.47 302.05, 120.29 -95.45, 18.7 in-in in 8.8322 Saltbr-in 2.6869 HRD-in -71.9, -45.8 76.46, -12.96 in-out-out SNCioo out-out ActLoopNT-out 8.8362 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 1.06 APE8-dihe-in -111.33, 130.78 APE8-rot-in 270.85 APE67-dihe-in -58.13, -22.76 -124.23, 26.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0634 None None None XRAY 2.573 0.192 0.262 A 414.0 336.0 25 31 16 15 [[22, 335]] 1.0 9h8c CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 9H8SA P49336 1 362 464.0 A1ITF:60509 Type1 Inactive DFGin 7.3437 13.9243 BLAminus -119.28, 163.44 74.84, 82.25 -92.61, 11.91 298.93, 132.0 -87.41, 10.8 in-in in 8.6117 Saltbr-in 2.6241 HRD-in -75.25, -51.5 79.06, -6.52 in-out-out SNCioo out-out ActLoopNT-out 8.6589 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.05 APE8-rot-out 75.96 APE67-dihe-in -54.19, -23.95 -111.96, 19.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.157 0.197 0.248 A 414.0 335.0 27 31 14 17 [[22, 335]] 1.0 9h8s CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 8TQ2A P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 5.9534 13.4093 BLAplus -149.38, -174.61 57.66, 42.3 -94.56, 56.63 80.28, 25.13 -65.65, -33.03 in-out in 9.074 Saltbr-out 5.0175 HRD-in -71.17, -43.38 62.04, 12.67 out-in-out SNCoio in-out ActLoopNT-in 2.9073 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.63, -27.07 APE9-dihe-na -152.97, 160.77 APE8-dihe-in -61.74, 149.93 APE8-rot-out 187.22 APE67-dihe-in -65.55, -27.76 -65.32, -15.56 APE12-dist-in 13.0056 APE11-dist-in 10.6044 APE10-dist-in 7.3395 APE9-dist-in 4.2314 None None None EM 3.8 999.0 999.0 A 464.0 313.0 46 31 31 0 [[22, 335]] 1.0 8tq2 CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 8TQCA P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 5.954 13.4098 BLAplus -149.38, -174.65 57.7, 42.3 -94.58, 56.63 80.22, 25.15 -65.67, -33.03 in-out in 9.0736 Saltbr-out 5.0166 HRD-in -71.16, -43.39 62.07, 12.66 out-in-out SNCoio in-out ActLoopNT-in 2.9071 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.64, -27.07 APE9-dihe-na -152.99, 160.74 APE8-dihe-in -61.68, 149.91 APE8-rot-out 187.24 APE67-dihe-in -65.64, -27.68 -65.36, -15.51 APE12-dist-in 13.006 APE11-dist-in 10.6041 APE10-dist-in 7.3394 APE9-dist-in 4.2313 None None None EM 3.8 999.0 999.0 A 464.0 313.0 46 31 31 0 [[22, 335]] 1.0 8tqc CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 8TQWA P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 6.9194 11.7033 BLAplus -136.58, -174.19 58.52, 55.8 -94.53, 48.46 79.76, 124.7 -72.57, -22.17 in-out in 9.013 Saltbr-out 4.2612 HRD-in -69.7, -41.94 60.18, 16.8 out-in-out SNCoio in-out ActLoopNT-in 3.2241 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -107.3, -18.61 APE9-dihe-na -153.74, 161.23 APE8-dihe-in -65.82, 153.77 APE8-rot-out 180.15 APE67-dihe-in -67.85, -29.18 -70.07, -16.17 APE12-dist-in 12.7643 APE11-dist-in 10.6621 APE10-dist-in 7.0853 APE9-dist-in 4.3173 None None None EM 8.2 999.0 999.0 a 464.0 313.0 46 31 31 0 [[22, 335]] 1.0 8tqw CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 4G6LA P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 7.7821 13.1649 BLBminus -140.33, 170.43 60.07, 39.76 -65.01, 139.84 287.11, 130.96 -72.68, 84.6 in-in in 9.41 Saltbr-in 2.7316 HRD-in -90.39, -58.08 80.12, -10.69 in-out-none SNCion out-none ActLoopNT-out 8.7909 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.75, -20.61 999.0, 14.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.214 0.266 A 406.0 333.0 26 31 19 12 [[22, 335]] 1.0 4g6l CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5FGKA P49336 1 362 464.0 5XG:60401 Type1 Inactive DFGin 8.4978 15.5831 BLBminus -133.54, 169.31 57.53, 42.29 -55.85, 144.8 295.15, 85.37 -70.31, 91.66 in-in in 9.829 Saltbr-in 2.8534 HRD-in -79.53, -56.66 86.65, -4.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.88 APE8-dihe-in -124.66, 135.5 APE8-rot-in 267.49 APE67-dihe-in -66.95, -24.09 -119.64, 24.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.9461 None None None XRAY 2.36 999.0 0.237 A 364.0 331.0 31 31 14 17 [[22, 335]] 1.0 5fgk CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5HBEA P49336 1 361 464.0 5Y6:60401 Type1 Inactive DFGin 6.3817 13.4796 BLBminus -150.55, 174.93 54.88, 46.99 -64.39, 138.78 282.35, 68.64 -73.7, 83.07 in-in in 9.4752 Saltbr-in 2.6635 HRD-in -80.78, -53.55 75.81, 1.36 in-out-out SNCioo out-out ActLoopNT-out 9.0331 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 124.46 APE8-dihe-in -128.69, 136.48 APE8-rot-out 167.77 APE67-dihe-in -66.35, -22.41 -120.15, 22.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.377 None None None XRAY 2.38 0.23 0.256 A 364.0 343.0 18 31 22 9 [[22, 335]] 1.0 5hbe CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5HNBA P49336 1 359 464.0 62M:60401 Type1 Inactive DFGin 6.6498 13.1706 BLBminus -138.74, 167.16 57.27, 44.77 -53.04, 139.99 284.36, 64.87 -77.11, 80.76 in-in in 9.3522 Saltbr-in 2.6998 HRD-in -81.89, -52.43 75.49, 2.56 in-out-out SNCioo out-out ActLoopNT-out 8.8745 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 22.41 APE8-rot-in 326.4 APE67-dihe-out -68.33, -25.9 68.06, 1.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.35 0.218 0.252 A 370.0 339.0 20 31 21 10 [[22, 335]] 1.0 5hnb CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5I5ZA P49336 1 362 464.0 68U:60401 Type1 Inactive DFGin 6.4155 13.0643 BLBminus -146.19, 175.23 51.04, 37.29 -51.44, 128.07 281.53, 66.91 -69.5, 65.99 in-in in 9.1148 Saltbr-in 2.9017 HRD-in -79.94, -54.75 78.35, 1.56 in-out-out SNCioo out-out ActLoopNT-out 8.7902 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 116.55 APE8-rot-out 180.69 APE67-dihe-in -62.72, -27.98 -92.64, 5.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.239 0.274 A 370.0 342.0 20 31 21 10 [[22, 335]] 1.0 5i5z CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5IDPA P49336 1 359 464.0 6A6:60401 Type1 Inactive DFGin 6.659 13.1177 BLBminus -136.27, 172.07 59.2, 45.18 -61.59, 132.52 281.19, 68.65 -74.88, 80.04 in-in in 9.3926 Saltbr-in 2.8965 HRD-in -79.39, -54.81 77.61, 1.02 in-out-out SNCioo out-out ActLoopNT-out 8.6935 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 164.27 APE8-rot-out 60.39 APE67-dihe-in -68.82, -22.92 -114.95, 18.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.232 0.272 A 370.0 341.0 18 31 21 10 [[22, 335]] 1.0 5idp CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 4F7SA P49336 1 359 464.0 0SW:60501 Type1 Inactive DFGin 6.495 13.0688 BLBminus -136.61, 176.12 53.35, 42.37 -54.98, 136.0 280.12, 74.29 -77.21, 78.52 in-in in 9.2294 Saltbr-in 2.7473 HRD-in -79.34, -55.77 76.41, 2.24 in-out-out SNCioo out-out ActLoopNT-out 8.7597 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.9 APE8-rot-out 180.5 APE67-dihe-in -68.08, -24.25 -110.68, 14.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.194 0.222 A 405.0 339.0 20 31 22 9 [[22, 335]] 1.0 4f7s CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5BNJA P49336 1 362 464.0 4TV:60501 Type1 Inactive DFGin 6.1998 14.6125 BLBminus -127.23, 163.17 60.48, 55.04 -65.81, 148.47 290.88, 72.47 -70.37, 93.4 in-in in 9.8117 Saltbr-in 2.7276 HRD-in -79.48, -50.1 76.1, -2.58 in-out-out SNCioo out-out ActLoopNT-out 8.736 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 162.07 APE8-rot-out 56.78 APE67-dihe-in -68.21, -22.51 -112.22, 14.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.64 0.228 0.273 A 405.0 341.0 21 31 20 11 [[22, 335]] 1.0 5bnj CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 6QTGA P49336 1 359 464.0 JH8:60501 Type1 Inactive DFGin 6.8548 13.5978 BLBminus -115.69, 168.8 67.93, 119.69 -128.98, 119.87 314.23, 115.38 -156.88, 999.0 in-in in 8.458 Saltbr-in 2.9444 HRD-in -69.43, -47.54 81.38, -19.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -47.73 APE8-dihe-in -122.24, 124.81 APE8-rot-in 266.36 APE67-dihe-in -67.96, -18.93 -113.56, 25.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0679 None None None XRAY 2.7 0.202 0.231 A 405.0 328.0 31 31 12 19 [[22, 335]] 1.0 6qtg CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 4CRLA P49336 1 359 464.0 C1I:61360 Type1 Inactive DFGin 6.2635 12.9653 BLBminus -130.84, 167.17 41.28, 61.34 -57.58, 143.29 285.19, 53.46 -56.15, 77.43 in-in in 9.2784 Saltbr-in 2.7647 HRD-in -77.87, -48.76 70.82, 12.4 in-out-out SNCioo out-out ActLoopNT-out 8.8293 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -12.95 APE8-dihe-in -65.77, 114.52 APE8-rot-out 186.25 APE67-dihe-in -70.31, -18.88 -108.2, 7.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3551 None None None XRAY 2.4 0.201 0.256 A 406.0 336.0 23 31 21 10 [[22, 335]] 1.0 4crl CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5CEIA P49336 1 362 464.0 50R:60508 Type1 Inactive DFGin 6.4332 13.0148 BLBminus -132.66, 174.92 55.78, 44.71 -56.21, 137.6 280.16, 70.73 -77.01, 72.68 in-in in 9.2797 Saltbr-in 2.5792 HRD-in -79.82, -54.28 77.75, 0.99 in-out-out SNCioo out-out ActLoopNT-out 8.6632 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 169.41 APE8-rot-out 67.16 APE67-dihe-in -60.87, -22.55 -115.47, 18.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.24 0.175 0.227 A 406.0 344.0 18 31 22 9 [[22, 335]] 1.0 5cei CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 6R3SA P49336 1 362 464.0 JRE:60501 Type1 Inactive DFGin 6.4489 13.1166 BLBminus -136.26, 169.85 57.34, 42.45 -52.43, 144.8 287.58, 63.16 -78.12, 79.2 in-in in 9.3756 Saltbr-in 2.8296 HRD-in -80.26, -51.73 75.92, 4.6 in-out-out SNCioo out-out ActLoopNT-out 8.6882 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.83 APE8-rot-out 181.78 APE67-dihe-in -67.95, -25.35 -103.82, 11.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.19 0.202 0.227 A 406.0 343.0 19 31 22 9 [[22, 335]] 1.0 6r3s CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 6Y0AA P49336 1 362 464.0 JRE:60501 Type1 Inactive DFGin 6.4489 13.1166 BLBminus -136.26, 169.85 57.34, 42.45 -52.43, 144.8 287.58, 63.16 -78.12, 79.2 in-in in 9.3756 Saltbr-in 2.8296 HRD-in -80.26, -51.73 75.92, 4.6 in-out-out SNCioo out-out ActLoopNT-out 8.6882 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.83 APE8-rot-out 181.78 APE67-dihe-in -67.95, -25.35 -103.82, 11.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.19 0.202 0.227 A 406.0 343.0 19 31 22 9 [[22, 335]] 1.0 6y0a CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 6T41A P49336 1 359 464.0 MFE:60501 Type1 Inactive DFGin 8.6301 13.5154 BLBminus -130.72, 167.87 65.4, 35.77 -47.77, 142.68 290.97, 94.77 -79.52, 87.36 in-in in 9.2255 Saltbr-in 2.9666 HRD-in -82.44, -61.41 81.57, -4.44 in-out-out SNCioo out-out ActLoopNT-out 8.8749 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 161.03 APE8-rot-out 58.35 APE67-dihe-in -69.81, -18.57 -101.28, 19.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.185 0.256 A 407.0 343.0 16 31 22 9 [[22, 335]] 1.0 6t41 CMGC_CDK8_HUMAN CMGC 6e-82 281.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5HBHA P49336 1 361 464.0 5Y7:60401 Type1 Inactive DFGin 5.4841 13.3356 BLBplus -129.14, 169.91 65.09, 34.73 -89.33, 139.59 54.15, 87.69 88.57, 16.73 in-in in 9.1442 Saltbr-in 2.8415 HRD-in -73.61, -55.97 88.78, -11.96 in-out-out SNCioo out-out ActLoopNT-out 9.6525 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 146.42 APE9-dihe-na -93.82, 144.5 APE8-dihe-in -120.03, 143.32 APE8-rot-out 75.1 APE67-dihe-in -65.56, -22.05 -107.02, 22.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.8418 APE9-dist-out 12.1846 None None None XRAY 2.5 0.235 0.268 A 364.0 334.0 27 31 17 14 [[22, 335]] 1.0 5hbh CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 3RGFA P49336 1 353 464.0 BAX:60465 Type2 Inactive DFGout 15.0897 10.8645 BBAminus -128.79, 167.92 -135.88, 84.21 -83.29, -7.22 304.7, 18.84 -121.06, 44.25 in-out in 9.3695 Saltbr-out 4.8518 HRD-in -76.1, -55.23 78.73, 2.83 out-out-out SNCooo out-out ActLoopNT-out 12.2242 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 133.12 APE8-dihe-in -111.84, 132.17 APE8-rot-out 185.32 APE67-dihe-in -67.42, -19.98 -109.35, 18.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6368 None None None XRAY 2.2 0.183 0.221 A 405.0 319.0 34 31 15 16 [[22, 335]] 1.0 3rgf CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 4F6UA P49336 1 359 464.0 0SR:60501 Type2 Inactive DFGout 14.5288 8.1472 BBAminus -137.04, 173.39 -132.48, 97.94 -82.11, -23.16 303.07, 124.54 89.51, -145.66 in-in in 8.5274 Saltbr-in 2.6265 HRD-in -75.69, -54.68 80.97, 0.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, -48.5 APE9-dihe-na -168.88, 136.11 APE8-dihe-in -116.43, 154.29 APE8-rot-out 81.86 APE67-dihe-in -65.37, -20.81 -106.87, 16.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.2334 APE9-dist-out 10.9418 None None None XRAY 2.1 0.177 0.198 A 405.0 332.0 27 31 14 17 [[22, 335]] 1.0 4f6u CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 4F6WA P49336 1 359 464.0 0SS:60501 Type2 Inactive DFGout 17.0447 13.9468 BBAminus -134.04, 175.74 -149.99, 134.58 -80.54, -17.82 302.37, 168.31 89.71, 32.24 in-in in 8.5227 Saltbr-in 2.6647 HRD-in -81.35, -56.06 84.43, -4.37 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 94.48 APE8-rot-in 298.45 APE67-dihe-in -64.37, -22.4 -100.8, 19.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.193 0.234 A 405.0 330.0 29 31 13 18 [[22, 335]] 1.0 4f6w CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 4F7LA P49336 1 359 464.0 0SO:60501 Type2 Inactive DFGout 13.5433 10.487 BBAminus -144.39, 166.94 -130.48, 125.05 -101.12, -66.88 314.21, 89.91 174.94, 999.0 in-in in 9.0525 Saltbr-in 2.7304 HRD-in -72.87, -46.64 81.38, -4.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.76 APE8-rot-out 66.51 APE67-dihe-in -72.52, -24.41 -123.27, 25.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.226 0.27 A 405.0 326.0 33 31 11 20 [[22, 335]] 1.0 4f7l CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 4F7NA P49336 1 361 464.0 0SV:60501 Type2 Inactive DFGout 14.194 8.2102 BBAminus -139.77, 176.54 -136.01, 97.7 -86.48, -26.06 306.23, 126.32 100.15, -136.94 in-in in 8.7798 Saltbr-in 2.7862 HRD-in -78.13, -54.62 75.98, 5.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, 43.71 APE9-dihe-na -114.3, 132.58 APE8-dihe-in -127.74, 146.12 APE8-rot-out 68.03 APE67-dihe-in -66.61, -22.51 -99.38, 17.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.8201 APE9-dist-out 11.2715 None None None XRAY 2.65 0.2 0.228 A 405.0 333.0 28 31 14 17 [[22, 335]] 1.0 4f7n CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 5HVYA P49336 1 359 464.0 66X:60501 Type2 Inactive DFGout 15.175 9.3117 BBAminus -147.75, 175.04 -130.64, 103.81 -80.2, 9.83 305.77, 118.03 84.07, 29.62 out-out out 11.2669 Saltbr-out 6.1116 HRD-in -85.57, -56.75 82.18, -2.99 out-out-out SNCooo out-out ActLoopNT-out 12.8606 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -86.7, 132.16 APE9-dihe-na -171.76, 167.74 APE8-dihe-in -116.95, 139.23 APE8-rot-out 61.83 APE67-dihe-in -58.0, -28.58 -98.28, 0.53 APE12-dist-out 14.3713 APE11-dist-in 9.0319 APE10-dist-out 8.2992 APE9-dist-out 10.3787 None None None XRAY 2.39 0.181 0.22 A 406.0 333.0 26 31 19 12 [[22, 335]] 1.0 5hvy CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 6TPAA P49336 1 359 464.0 NZ8:60501,NZ5:60505,NZ5:60506,NZ5:60507 Type2,Allosteric,Allosteric,Allosteric Inactive DFGout 13.8318 11.8175 BBAminus -130.48, -178.36 -144.36, 91.14 -84.2, -4.16 322.15, 13.04 -124.91, 44.75 out-out out 10.1823 Saltbr-out 4.9546 HRD-in -82.95, -50.83 78.95, 15.78 out-out-out SNCooo out-out ActLoopNT-out 11.9075 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.19 APE8-rot-out 87.86 APE67-dihe-in -63.33, -23.46 -113.41, 27.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.228 0.264 A 405.0 334.0 25 31 15 16 [[22, 335]] 1.0 6tpa CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 4F6SA P49336 1 359 464.0 0SQ:60501 Type3 Inactive DFGout 13.8778 7.5572 BBAminus -143.37, 174.31 -133.59, 95.54 -89.33, -12.55 298.0, 127.79 85.97, -154.1 in-in in 8.6698 Saltbr-in 2.8135 HRD-in -74.89, -55.83 78.59, -0.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.84 APE8-dihe-in -132.11, 155.15 APE8-rot-out 82.42 APE67-dihe-in -62.47, -25.65 -106.71, 17.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8701 None None None XRAY 2.6 0.205 0.26 A 405.0 327.0 32 31 14 17 [[22, 335]] 1.0 4f6s CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 4F7JA P49336 1 359 464.0 0SU:60501 Type3 Inactive DFGout 14.4229 8.5945 BBAminus -131.55, -173.38 -148.17, 95.28 -72.43, -38.8 311.88, 131.51 104.34, -133.92 in-in in 8.7236 Saltbr-in 2.6641 HRD-in -75.51, -51.42 85.3, -13.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.87 APE8-dihe-in -70.46, 100.26 APE8-rot-in 296.32 APE67-dihe-in -60.95, -26.84 -87.97, 10.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.055 None None None XRAY 2.6 0.229 0.276 A 405.0 326.0 33 31 13 18 [[22, 335]] 1.0 4f7j CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 4F70A P49336 1 359 464.0 0ST:60501 Type3 Inactive None 18.6473 14.4213 None -123.12, -177.92 -154.05, 113.27 -90.85, 999.0 75.63, 12.09 999.0, 999.0 in-in in 8.9927 Saltbr-in 3.0079 HRD-in -82.85, -48.58 74.91, -2.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 73.37 APE8-dihe-in -133.51, 141.85 APE8-rot-out 58.33 APE67-dihe-in -73.19, -29.13 -108.0, 28.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5615 None None None XRAY 3.0 0.204 0.239 A 405.0 326.0 33 31 11 20 [[22, 335]] 1.0 4f70 CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8

CMGC_CDK8 (Cyclin-dependent kinase 8)

Total number of chains: 38
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 14 36.8% 6T41A
DFGin BLAminus 10 26.3% AF-P49336-K1A
DFGout BBAminus 9 23.7% 6TPAA
DFGin BLAplus 3 7.9% 8TQ2A
DFGin BLBplus 1 2.6% 5HBHA
None None 1 2.6% 4F70A

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK8 CDK8_HUMAN AF-P49336-K1A P49336 12 343 464.0 No_ligand No_ligand Active DFGin 6.9313 15.6629 BLAminus -128.17, 177.28 55.68, 59.43 -72.54, 15.56 300.04, 114.68 -62.04, -32.39 in-in in 9.1654 Saltbr-in 2.8975 HRD-in -73.5, -51.19 62.86, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.8327 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.05, 164.39 APE9-dihe-na 83.32, 124.4 APE8-dihe-in -52.27, 134.37 APE8-rot-in 287.61 APE67-dihe-in -65.17, -26.48 -44.23, -41.35 APE12-dist-in 12.0588 APE11-dist-in 11.607 APE10-dist-in 5.8083 APE9-dist-in 3.4091 None None None AF2 -1.0 1.0 1.0 A 332.0 332.0 0 31 31 0 [[22, 335]] 1.0 AF-P49336-K1 Homo sapiens CMGC_CDK8_HUMAN CMGC 2.9e-82 282.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN AF-P49336-K3A P49336 12 343 464.0 No_ligand No_ligand Active DFGin 7.0585 14.4146 BLAminus -125.11, 179.05 58.06, 66.16 -75.42, 13.63 298.43, 116.53 -58.59, -38.0 in-in in 9.222 Saltbr-in 2.7201 HRD-in -77.81, -49.38 63.32, 9.66 in-in-in SNCiii in-in ActLoopNT-in 2.8729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.07, 166.88 APE9-dihe-na 60.71, 128.33 APE8-dihe-in -54.75, 135.42 APE8-rot-in 297.36 APE67-dihe-in -67.37, -15.46 -44.59, -50.0 APE12-dist-in 12.5614 APE11-dist-in 10.811 APE10-dist-in 6.5807 APE9-dist-in 3.286 None None None AF2 -1.0 1.0 1.0 A 332.0 332.0 0 31 31 0 [[22, 335]] 1.0 AF-P49336-K3 Homo sapiens CMGC_CDK8_HUMAN CMGC 2.9e-82 282.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5HBJA P49336 1 361 464.0 5Y8:60401 Type1 Inactive DFGin 7.5418 14.7786 BLAminus -106.87, 176.98 71.07, 89.31 -114.96, 61.9 305.41, 118.79 -100.84, -170.16 in-in in 9.7609 Saltbr-in 2.6824 HRD-in -77.67, -52.92 73.2, 5.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -16.09 APE8-dihe-in -117.57, 98.85 APE8-rot-in 304.83 APE67-dihe-in -72.47, -22.93 -102.77, 29.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.3779 None None None XRAY 3.0 999.0 0.288 A 364.0 340.0 21 31 19 12 [[22, 335]] 1.0 5hbj Homo sapiens CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5ICPA P49336 1 362 464.0 69Z:60401 Type1 Inactive DFGin 6.1473 13.6394 BLAminus -129.39, 179.13 50.41, 56.76 -66.42, 4.81 256.2, 78.89 56.91, 53.37 in-in in 9.1898 Saltbr-in 2.5875 HRD-in -78.65, -54.95 77.97, -2.02 in-out-out SNCioo out-out ActLoopNT-out 8.7892 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 83.07 APE9-dihe-na -127.02, 140.47 APE8-dihe-in -112.3, 142.07 APE8-rot-out 57.72 APE67-dihe-in -65.52, -25.52 -110.98, 18.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.6843 APE9-dist-out 12.5091 None None None XRAY 2.18 0.185 0.216 A 364.0 343.0 19 31 23 8 [[22, 335]] 1.0 5icp Homo sapiens CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5IDNA P49336 1 363 464.0 6A7:60401 Type1 Inactive DFGin 7.3226 16.0877 BLAminus -124.47, 174.0 67.51, 75.48 -91.55, 21.99 294.62, 123.1 -96.7, 0.53 in-in in 8.9702 Saltbr-in 2.647 HRD-in -71.0, -49.83 80.54, -0.94 in-out-out SNCioo out-out ActLoopNT-out 8.4045 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.78 APE8-dihe-in -125.68, 150.04 APE8-rot-out 46.55 APE67-dihe-in -67.71, -25.83 -125.87, 33.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7732 None None None XRAY 2.26 0.221 0.253 A 370.0 336.0 27 31 15 16 [[22, 335]] 1.0 5idn Homo sapiens CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5XQXA P49336 1 362 464.0 8CC:60402 Type1 Inactive DFGin 7.1009 13.3766 BLAminus -124.76, 173.54 67.85, 87.06 -93.65, 13.06 285.44, 142.36 -53.92, -30.2 in-in in 8.5993 Saltbr-in 2.6458 HRD-in -76.07, -52.85 74.84, 2.4 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.45 APE8-dihe-in -121.89, 118.59 APE8-rot-in 276.05 APE67-dihe-in -59.33, -23.95 -109.46, 21.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0086 None None None XRAY 2.3 0.19 0.222 A 380.0 337.0 25 31 18 13 [[22, 335]] 1.0 5xqx Homo sapiens CMGC_CDK8_HUMAN CMGC 4.7e-82 281.6 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5XS2A P49336 1 363 464.0 8D6:60402 Type1 Inactive DFGin 7.1 13.2185 BLAminus -125.86, 168.92 68.44, 89.08 -85.59, 13.7 295.46, 132.91 -57.29, -23.08 in-in in 8.5472 Saltbr-in 2.6849 HRD-in -77.09, -53.4 74.45, 0.97 in-in-out SNCiio in-out ActLoopNT-in 2.7249 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -119.34, 129.98 APE9-dihe-na -115.73, -15.25 APE8-dihe-in -128.4, 144.08 APE8-rot-out 53.94 APE67-dihe-in -59.75, -24.05 -125.87, 25.67 APE12-dist-in 7.1385 APE11-dist-in 11.8021 APE10-dist-out 9.8465 APE9-dist-out 12.3679 None None None XRAY 2.04 0.197 0.225 A 380.0 363.0 0 31 31 0 [[22, 335]] 1.0 5xs2 Homo sapiens CMGC_CDK8_HUMAN CMGC 4.7e-82 281.6 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 6QTJA P49336 1 359 464.0 JHK:60501 Type1 Inactive DFGin 7.5864 14.0745 BLAminus -112.22, -179.25 62.71, 86.71 -102.98, 13.61 301.92, 111.63 -83.54, 3.25 in-in in 8.4612 Saltbr-in 2.9368 HRD-in -68.14, -49.62 76.51, -6.19 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.96 APE8-dihe-in -121.23, 128.93 APE8-rot-in 272.12 APE67-dihe-in -58.17, -25.47 -117.92, 17.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.2357 None None None XRAY 2.48 0.187 0.22 A 405.0 329.0 30 31 13 18 [[22, 335]] 1.0 6qtj Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 9H8CA P49336 1 361 464.0 A1IS8:60503 Type1 Inactive DFGin 7.5455 14.2354 BLAminus -123.76, 163.44 68.83, 82.68 -94.14, 12.47 302.05, 120.29 -95.45, 18.7 in-in in 8.8322 Saltbr-in 2.6869 HRD-in -71.9, -45.8 76.46, -12.96 in-out-out SNCioo out-out ActLoopNT-out 8.8362 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 1.06 APE8-dihe-in -111.33, 130.78 APE8-rot-in 270.85 APE67-dihe-in -58.13, -22.76 -124.23, 26.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0634 None None None XRAY 2.573 0.192 0.262 A 414.0 336.0 25 31 16 15 [[22, 335]] 1.0 9h8c Homo sapiens CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 9H8SA P49336 1 362 464.0 A1ITF:60509 Type1 Inactive DFGin 7.3437 13.9243 BLAminus -119.28, 163.44 74.84, 82.25 -92.61, 11.91 298.93, 132.0 -87.41, 10.8 in-in in 8.6117 Saltbr-in 2.6241 HRD-in -75.25, -51.5 79.06, -6.52 in-out-out SNCioo out-out ActLoopNT-out 8.6589 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.05 APE8-rot-out 75.96 APE67-dihe-in -54.19, -23.95 -111.96, 19.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.157 0.197 0.248 A 414.0 335.0 27 31 14 17 [[22, 335]] 1.0 9h8s Homo sapiens CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 8TQ2A P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 5.9534 13.4093 BLAplus -149.38, -174.61 57.66, 42.3 -94.56, 56.63 80.28, 25.13 -65.65, -33.03 in-out in 9.074 Saltbr-out 5.0175 HRD-in -71.17, -43.38 62.04, 12.67 out-in-out SNCoio in-out ActLoopNT-in 2.9073 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.63, -27.07 APE9-dihe-na -152.97, 160.77 APE8-dihe-in -61.74, 149.93 APE8-rot-out 187.22 APE67-dihe-in -65.55, -27.76 -65.32, -15.56 APE12-dist-in 13.0056 APE11-dist-in 10.6044 APE10-dist-in 7.3395 APE9-dist-in 4.2314 None None None EM 3.8 999.0 999.0 A 464.0 313.0 46 31 31 0 [[22, 335]] 1.0 8tq2 Homo sapiens CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 8TQCA P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 5.954 13.4098 BLAplus -149.38, -174.65 57.7, 42.3 -94.58, 56.63 80.22, 25.15 -65.67, -33.03 in-out in 9.0736 Saltbr-out 5.0166 HRD-in -71.16, -43.39 62.07, 12.66 out-in-out SNCoio in-out ActLoopNT-in 2.9071 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.64, -27.07 APE9-dihe-na -152.99, 160.74 APE8-dihe-in -61.68, 149.91 APE8-rot-out 187.24 APE67-dihe-in -65.64, -27.68 -65.36, -15.51 APE12-dist-in 13.006 APE11-dist-in 10.6041 APE10-dist-in 7.3394 APE9-dist-in 4.2313 None None None EM 3.8 999.0 999.0 A 464.0 313.0 46 31 31 0 [[22, 335]] 1.0 8tqc Homo sapiens CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 8TQWA P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 6.9194 11.7033 BLAplus -136.58, -174.19 58.52, 55.8 -94.53, 48.46 79.76, 124.7 -72.57, -22.17 in-out in 9.013 Saltbr-out 4.2612 HRD-in -69.7, -41.94 60.18, 16.8 out-in-out SNCoio in-out ActLoopNT-in 3.2241 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -107.3, -18.61 APE9-dihe-na -153.74, 161.23 APE8-dihe-in -65.82, 153.77 APE8-rot-out 180.15 APE67-dihe-in -67.85, -29.18 -70.07, -16.17 APE12-dist-in 12.7643 APE11-dist-in 10.6621 APE10-dist-in 7.0853 APE9-dist-in 4.3173 None None None EM 8.2 999.0 999.0 a 464.0 313.0 46 31 31 0 [[22, 335]] 1.0 8tqw Homo sapiens CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 4G6LA P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 7.7821 13.1649 BLBminus -140.33, 170.43 60.07, 39.76 -65.01, 139.84 287.11, 130.96 -72.68, 84.6 in-in in 9.41 Saltbr-in 2.7316 HRD-in -90.39, -58.08 80.12, -10.69 in-out-none SNCion out-none ActLoopNT-out 8.7909 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.75, -20.61 999.0, 14.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.214 0.266 A 406.0 333.0 26 31 19 12 [[22, 335]] 1.0 4g6l Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5FGKA P49336 1 362 464.0 5XG:60401 Type1 Inactive DFGin 8.4978 15.5831 BLBminus -133.54, 169.31 57.53, 42.29 -55.85, 144.8 295.15, 85.37 -70.31, 91.66 in-in in 9.829 Saltbr-in 2.8534 HRD-in -79.53, -56.66 86.65, -4.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.88 APE8-dihe-in -124.66, 135.5 APE8-rot-in 267.49 APE67-dihe-in -66.95, -24.09 -119.64, 24.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.9461 None None None XRAY 2.36 999.0 0.237 A 364.0 331.0 31 31 14 17 [[22, 335]] 1.0 5fgk Homo sapiens CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5HBEA P49336 1 361 464.0 5Y6:60401 Type1 Inactive DFGin 6.3817 13.4796 BLBminus -150.55, 174.93 54.88, 46.99 -64.39, 138.78 282.35, 68.64 -73.7, 83.07 in-in in 9.4752 Saltbr-in 2.6635 HRD-in -80.78, -53.55 75.81, 1.36 in-out-out SNCioo out-out ActLoopNT-out 9.0331 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 124.46 APE8-dihe-in -128.69, 136.48 APE8-rot-out 167.77 APE67-dihe-in -66.35, -22.41 -120.15, 22.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.377 None None None XRAY 2.38 0.23 0.256 A 364.0 343.0 18 31 22 9 [[22, 335]] 1.0 5hbe Homo sapiens CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5HNBA P49336 1 359 464.0 62M:60401 Type1 Inactive DFGin 6.6498 13.1706 BLBminus -138.74, 167.16 57.27, 44.77 -53.04, 139.99 284.36, 64.87 -77.11, 80.76 in-in in 9.3522 Saltbr-in 2.6998 HRD-in -81.89, -52.43 75.49, 2.56 in-out-out SNCioo out-out ActLoopNT-out 8.8745 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 22.41 APE8-rot-in 326.4 APE67-dihe-out -68.33, -25.9 68.06, 1.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.35 0.218 0.252 A 370.0 339.0 20 31 21 10 [[22, 335]] 1.0 5hnb Homo sapiens CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5I5ZA P49336 1 362 464.0 68U:60401 Type1 Inactive DFGin 6.4155 13.0643 BLBminus -146.19, 175.23 51.04, 37.29 -51.44, 128.07 281.53, 66.91 -69.5, 65.99 in-in in 9.1148 Saltbr-in 2.9017 HRD-in -79.94, -54.75 78.35, 1.56 in-out-out SNCioo out-out ActLoopNT-out 8.7902 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 116.55 APE8-rot-out 180.69 APE67-dihe-in -62.72, -27.98 -92.64, 5.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.239 0.274 A 370.0 342.0 20 31 21 10 [[22, 335]] 1.0 5i5z Homo sapiens CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5IDPA P49336 1 359 464.0 6A6:60401 Type1 Inactive DFGin 6.659 13.1177 BLBminus -136.27, 172.07 59.2, 45.18 -61.59, 132.52 281.19, 68.65 -74.88, 80.04 in-in in 9.3926 Saltbr-in 2.8965 HRD-in -79.39, -54.81 77.61, 1.02 in-out-out SNCioo out-out ActLoopNT-out 8.6935 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 164.27 APE8-rot-out 60.39 APE67-dihe-in -68.82, -22.92 -114.95, 18.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.232 0.272 A 370.0 341.0 18 31 21 10 [[22, 335]] 1.0 5idp Homo sapiens CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 4F7SA P49336 1 359 464.0 0SW:60501 Type1 Inactive DFGin 6.495 13.0688 BLBminus -136.61, 176.12 53.35, 42.37 -54.98, 136.0 280.12, 74.29 -77.21, 78.52 in-in in 9.2294 Saltbr-in 2.7473 HRD-in -79.34, -55.77 76.41, 2.24 in-out-out SNCioo out-out ActLoopNT-out 8.7597 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.9 APE8-rot-out 180.5 APE67-dihe-in -68.08, -24.25 -110.68, 14.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.194 0.222 A 405.0 339.0 20 31 22 9 [[22, 335]] 1.0 4f7s Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5BNJA P49336 1 362 464.0 4TV:60501 Type1 Inactive DFGin 6.1998 14.6125 BLBminus -127.23, 163.17 60.48, 55.04 -65.81, 148.47 290.88, 72.47 -70.37, 93.4 in-in in 9.8117 Saltbr-in 2.7276 HRD-in -79.48, -50.1 76.1, -2.58 in-out-out SNCioo out-out ActLoopNT-out 8.736 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 162.07 APE8-rot-out 56.78 APE67-dihe-in -68.21, -22.51 -112.22, 14.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.64 0.228 0.273 A 405.0 341.0 21 31 20 11 [[22, 335]] 1.0 5bnj Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 6QTGA P49336 1 359 464.0 JH8:60501 Type1 Inactive DFGin 6.8548 13.5978 BLBminus -115.69, 168.8 67.93, 119.69 -128.98, 119.87 314.23, 115.38 -156.88, 999.0 in-in in 8.458 Saltbr-in 2.9444 HRD-in -69.43, -47.54 81.38, -19.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -47.73 APE8-dihe-in -122.24, 124.81 APE8-rot-in 266.36 APE67-dihe-in -67.96, -18.93 -113.56, 25.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.0679 None None None XRAY 2.7 0.202 0.231 A 405.0 328.0 31 31 12 19 [[22, 335]] 1.0 6qtg Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 4CRLA P49336 1 359 464.0 C1I:61360 Type1 Inactive DFGin 6.2635 12.9653 BLBminus -130.84, 167.17 41.28, 61.34 -57.58, 143.29 285.19, 53.46 -56.15, 77.43 in-in in 9.2784 Saltbr-in 2.7647 HRD-in -77.87, -48.76 70.82, 12.4 in-out-out SNCioo out-out ActLoopNT-out 8.8293 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -12.95 APE8-dihe-in -65.77, 114.52 APE8-rot-out 186.25 APE67-dihe-in -70.31, -18.88 -108.2, 7.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.3551 None None None XRAY 2.4 0.201 0.256 A 406.0 336.0 23 31 21 10 [[22, 335]] 1.0 4crl Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5CEIA P49336 1 362 464.0 50R:60508 Type1 Inactive DFGin 6.4332 13.0148 BLBminus -132.66, 174.92 55.78, 44.71 -56.21, 137.6 280.16, 70.73 -77.01, 72.68 in-in in 9.2797 Saltbr-in 2.5792 HRD-in -79.82, -54.28 77.75, 0.99 in-out-out SNCioo out-out ActLoopNT-out 8.6632 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 169.41 APE8-rot-out 67.16 APE67-dihe-in -60.87, -22.55 -115.47, 18.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.24 0.175 0.227 A 406.0 344.0 18 31 22 9 [[22, 335]] 1.0 5cei Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 6R3SA P49336 1 362 464.0 JRE:60501 Type1 Inactive DFGin 6.4489 13.1166 BLBminus -136.26, 169.85 57.34, 42.45 -52.43, 144.8 287.58, 63.16 -78.12, 79.2 in-in in 9.3756 Saltbr-in 2.8296 HRD-in -80.26, -51.73 75.92, 4.6 in-out-out SNCioo out-out ActLoopNT-out 8.6882 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.83 APE8-rot-out 181.78 APE67-dihe-in -67.95, -25.35 -103.82, 11.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.19 0.202 0.227 A 406.0 343.0 19 31 22 9 [[22, 335]] 1.0 6r3s Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 6Y0AA P49336 1 362 464.0 JRE:60501 Type1 Inactive DFGin 6.4489 13.1166 BLBminus -136.26, 169.85 57.34, 42.45 -52.43, 144.8 287.58, 63.16 -78.12, 79.2 in-in in 9.3756 Saltbr-in 2.8296 HRD-in -80.26, -51.73 75.92, 4.6 in-out-out SNCioo out-out ActLoopNT-out 8.6882 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.83 APE8-rot-out 181.78 APE67-dihe-in -67.95, -25.35 -103.82, 11.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.19 0.202 0.227 A 406.0 343.0 19 31 22 9 [[22, 335]] 1.0 6y0a Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 6T41A P49336 1 359 464.0 MFE:60501 Type1 Inactive DFGin 8.6301 13.5154 BLBminus -130.72, 167.87 65.4, 35.77 -47.77, 142.68 290.97, 94.77 -79.52, 87.36 in-in in 9.2255 Saltbr-in 2.9666 HRD-in -82.44, -61.41 81.57, -4.44 in-out-out SNCioo out-out ActLoopNT-out 8.8749 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 161.03 APE8-rot-out 58.35 APE67-dihe-in -69.81, -18.57 -101.28, 19.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.185 0.256 A 407.0 343.0 16 31 22 9 [[22, 335]] 1.0 6t41 Homo sapiens CMGC_CDK8_HUMAN CMGC 6e-82 281.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5HBHA P49336 1 361 464.0 5Y7:60401 Type1 Inactive DFGin 5.4841 13.3356 BLBplus -129.14, 169.91 65.09, 34.73 -89.33, 139.59 54.15, 87.69 88.57, 16.73 in-in in 9.1442 Saltbr-in 2.8415 HRD-in -73.61, -55.97 88.78, -11.96 in-out-out SNCioo out-out ActLoopNT-out 9.6525 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 146.42 APE9-dihe-na -93.82, 144.5 APE8-dihe-in -120.03, 143.32 APE8-rot-out 75.1 APE67-dihe-in -65.56, -22.05 -107.02, 22.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.8418 APE9-dist-out 12.1846 None None None XRAY 2.5 0.235 0.268 A 364.0 334.0 27 31 17 14 [[22, 335]] 1.0 5hbh Homo sapiens CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 3RGFA P49336 1 353 464.0 BAX:60465 Type2 Inactive DFGout 15.0897 10.8645 BBAminus -128.79, 167.92 -135.88, 84.21 -83.29, -7.22 304.7, 18.84 -121.06, 44.25 in-out in 9.3695 Saltbr-out 4.8518 HRD-in -76.1, -55.23 78.73, 2.83 out-out-out SNCooo out-out ActLoopNT-out 12.2242 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 133.12 APE8-dihe-in -111.84, 132.17 APE8-rot-out 185.32 APE67-dihe-in -67.42, -19.98 -109.35, 18.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.6368 None None None XRAY 2.2 0.183 0.221 A 405.0 319.0 34 31 15 16 [[22, 335]] 1.0 3rgf Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 4F6UA P49336 1 359 464.0 0SR:60501 Type2 Inactive DFGout 14.5288 8.1472 BBAminus -137.04, 173.39 -132.48, 97.94 -82.11, -23.16 303.07, 124.54 89.51, -145.66 in-in in 8.5274 Saltbr-in 2.6265 HRD-in -75.69, -54.68 80.97, 0.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, -48.5 APE9-dihe-na -168.88, 136.11 APE8-dihe-in -116.43, 154.29 APE8-rot-out 81.86 APE67-dihe-in -65.37, -20.81 -106.87, 16.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.2334 APE9-dist-out 10.9418 None None None XRAY 2.1 0.177 0.198 A 405.0 332.0 27 31 14 17 [[22, 335]] 1.0 4f6u Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 4F6WA P49336 1 359 464.0 0SS:60501 Type2 Inactive DFGout 17.0447 13.9468 BBAminus -134.04, 175.74 -149.99, 134.58 -80.54, -17.82 302.37, 168.31 89.71, 32.24 in-in in 8.5227 Saltbr-in 2.6647 HRD-in -81.35, -56.06 84.43, -4.37 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 94.48 APE8-rot-in 298.45 APE67-dihe-in -64.37, -22.4 -100.8, 19.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.193 0.234 A 405.0 330.0 29 31 13 18 [[22, 335]] 1.0 4f6w Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 4F7LA P49336 1 359 464.0 0SO:60501 Type2 Inactive DFGout 13.5433 10.487 BBAminus -144.39, 166.94 -130.48, 125.05 -101.12, -66.88 314.21, 89.91 174.94, 999.0 in-in in 9.0525 Saltbr-in 2.7304 HRD-in -72.87, -46.64 81.38, -4.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.76 APE8-rot-out 66.51 APE67-dihe-in -72.52, -24.41 -123.27, 25.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.226 0.27 A 405.0 326.0 33 31 11 20 [[22, 335]] 1.0 4f7l Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 4F7NA P49336 1 361 464.0 0SV:60501 Type2 Inactive DFGout 14.194 8.2102 BBAminus -139.77, 176.54 -136.01, 97.7 -86.48, -26.06 306.23, 126.32 100.15, -136.94 in-in in 8.7798 Saltbr-in 2.7862 HRD-in -78.13, -54.62 75.98, 5.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, 43.71 APE9-dihe-na -114.3, 132.58 APE8-dihe-in -127.74, 146.12 APE8-rot-out 68.03 APE67-dihe-in -66.61, -22.51 -99.38, 17.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.8201 APE9-dist-out 11.2715 None None None XRAY 2.65 0.2 0.228 A 405.0 333.0 28 31 14 17 [[22, 335]] 1.0 4f7n Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 5HVYA P49336 1 359 464.0 66X:60501 Type2 Inactive DFGout 15.175 9.3117 BBAminus -147.75, 175.04 -130.64, 103.81 -80.2, 9.83 305.77, 118.03 84.07, 29.62 out-out out 11.2669 Saltbr-out 6.1116 HRD-in -85.57, -56.75 82.18, -2.99 out-out-out SNCooo out-out ActLoopNT-out 12.8606 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -86.7, 132.16 APE9-dihe-na -171.76, 167.74 APE8-dihe-in -116.95, 139.23 APE8-rot-out 61.83 APE67-dihe-in -58.0, -28.58 -98.28, 0.53 APE12-dist-out 14.3713 APE11-dist-in 9.0319 APE10-dist-out 8.2992 APE9-dist-out 10.3787 None None None XRAY 2.39 0.181 0.22 A 406.0 333.0 26 31 19 12 [[22, 335]] 1.0 5hvy Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 6TPAA P49336 1 359 464.0 NZ8:60501,NZ5:60505,NZ5:60506,NZ5:60507 Type2,Allosteric,Allosteric,Allosteric Inactive DFGout 13.8318 11.8175 BBAminus -130.48, -178.36 -144.36, 91.14 -84.2, -4.16 322.15, 13.04 -124.91, 44.75 out-out out 10.1823 Saltbr-out 4.9546 HRD-in -82.95, -50.83 78.95, 15.78 out-out-out SNCooo out-out ActLoopNT-out 11.9075 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.19 APE8-rot-out 87.86 APE67-dihe-in -63.33, -23.46 -113.41, 27.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.228 0.264 A 405.0 334.0 25 31 15 16 [[22, 335]] 1.0 6tpa Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 4F6SA P49336 1 359 464.0 0SQ:60501 Type3 Inactive DFGout 13.8778 7.5572 BBAminus -143.37, 174.31 -133.59, 95.54 -89.33, -12.55 298.0, 127.79 85.97, -154.1 in-in in 8.6698 Saltbr-in 2.8135 HRD-in -74.89, -55.83 78.59, -0.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.84 APE8-dihe-in -132.11, 155.15 APE8-rot-out 82.42 APE67-dihe-in -62.47, -25.65 -106.71, 17.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8701 None None None XRAY 2.6 0.205 0.26 A 405.0 327.0 32 31 14 17 [[22, 335]] 1.0 4f6s Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 4F7JA P49336 1 359 464.0 0SU:60501 Type3 Inactive DFGout 14.4229 8.5945 BBAminus -131.55, -173.38 -148.17, 95.28 -72.43, -38.8 311.88, 131.51 104.34, -133.92 in-in in 8.7236 Saltbr-in 2.6641 HRD-in -75.51, -51.42 85.3, -13.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.87 APE8-dihe-in -70.46, 100.26 APE8-rot-in 296.32 APE67-dihe-in -60.95, -26.84 -87.97, 10.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.055 None None None XRAY 2.6 0.229 0.276 A 405.0 326.0 33 31 13 18 [[22, 335]] 1.0 4f7j Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8 CDK8_HUMAN 4F70A P49336 1 359 464.0 0ST:60501 Type3 Inactive None 18.6473 14.4213 None -123.12, -177.92 -154.05, 113.27 -90.85, 999.0 75.63, 12.09 999.0, 999.0 in-in in 8.9927 Saltbr-in 3.0079 HRD-in -82.85, -48.58 74.91, -2.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 73.37 APE8-dihe-in -133.51, 141.85 APE8-rot-out 58.33 APE67-dihe-in -73.19, -29.13 -108.0, 28.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5615 None None None XRAY 3.0 0.204 0.239 A 405.0 326.0 33 31 11 20 [[22, 335]] 1.0 4f70 Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8

CMGC_CDK8 (Cyclin-dependent kinase 8)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name