CMGC_CDK8 (Cyclin-dependent kinase 8)

Total number of chains: 38
Active chains: 2
Family: CMGC
Uniprot: CDK8_HUMAN
Kinase Domain Residues: 20 - 335
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 14 36.8% 6T41A
DFGin BLAminus 10 26.3% AF-P49336-K1A
DFGout BBAminus 9 23.7% 6TPAA
DFGin BLAplus 3 7.9% 8TQ2A
DFGin BLBplus 1 2.6% 5HBHA
None None 1 2.6% 4F70A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P49336-K1A 12 343 464.0 No_ligand No_ligand Active DFGin 6.931 15.663 BLAminus -128.17, 177.28 55.68, 59.43 -72.54, 15.56 300.04, 114.68 -62.04, -32.39 in-in in 9.165 Saltbr-in 2.897 HRD-in -73.5, -51.19 62.86, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.05, 164.39 APE9-dihe-na 83.32, 124.4 APE8-dihe-in -52.27, 134.37 APE8-rot-in 287.61 APE67-dihe-in -65.17, -26.48 -44.23, -41.35 APE12-dist-in 12.059 APE11-dist-in 11.607 APE10-dist-in 5.808 APE9-dist-in 3.409 None None None AF2 -1.0 1.0 1.0 A 332 332 0 0 0 0 [[22, 335]] 1.0 AF-P49336-K1 CMGC_CDK8_HUMAN CMGC 2.9e-82 282.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
AF-P49336-K3A 12 343 464.0 No_ligand No_ligand Active DFGin 7.059 14.415 BLAminus -125.11, 179.05 58.06, 66.16 -75.42, 13.63 298.43, 116.53 -58.59, -38.0 in-in in 9.222 Saltbr-in 2.72 HRD-in -77.81, -49.38 63.32, 9.66 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.07, 166.88 APE9-dihe-na 60.71, 128.33 APE8-dihe-in -54.75, 135.42 APE8-rot-in 297.36 APE67-dihe-in -67.37, -15.46 -44.59, -50.0 APE12-dist-in 12.561 APE11-dist-in 10.811 APE10-dist-in 6.581 APE9-dist-in 3.286 None None None AF2 -1.0 1.0 1.0 A 332 332 0 0 0 0 [[22, 335]] 1.0 AF-P49336-K3 CMGC_CDK8_HUMAN CMGC 2.9e-82 282.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5HBJA 1 361 464.0 5Y8:60401 Type1 Inactive DFGin 7.542 14.779 BLAminus -106.87, 176.98 71.07, 89.31 -114.96, 61.9 305.41, 118.79 -100.84, -170.16 in-in in 9.761 Saltbr-in 2.682 HRD-in -77.67, -52.92 73.2, 5.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -16.09 APE8-dihe-in -117.57, 98.85 APE8-rot-in 304.83 APE67-dihe-in -72.47, -22.93 -102.77, 29.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.378 None None None XRAY 3.0 999.0 0.288 A 364 340 21 0 0 12 [[22, 335]] 1.0 5hbj CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5ICPA 1 362 464.0 69Z:60401 Type1 Inactive DFGin 6.147 13.639 BLAminus -129.39, 179.13 50.41, 56.76 -66.42, 4.81 256.2, 78.89 56.91, 53.37 in-in in 9.19 Saltbr-in 2.587 HRD-in -78.65, -54.95 77.97, -2.02 in-out-out SNCioo out-out ActLoopNT-out 8.789 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 83.07 APE9-dihe-na -127.02, 140.47 APE8-dihe-in -112.3, 142.07 APE8-rot-out 57.72 APE67-dihe-in -65.52, -25.52 -110.98, 18.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.684 APE9-dist-out 12.509 None None None XRAY 2.18 0.185 0.216 A 364 343 19 0 0 8 [[22, 335]] 1.0 5icp CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5IDNA 1 363 464.0 6A7:60401 Type1 Inactive DFGin 7.323 16.088 BLAminus -124.47, 174.0 67.51, 75.48 -91.55, 21.99 294.62, 123.1 -96.7, 0.53 in-in in 8.97 Saltbr-in 2.647 HRD-in -71.0, -49.83 80.54, -0.94 in-out-out SNCioo out-out ActLoopNT-out 8.405 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.78 APE8-dihe-in -125.68, 150.04 APE8-rot-out 46.55 APE67-dihe-in -67.71, -25.83 -125.87, 33.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.773 None None None XRAY 2.26 0.221 0.253 A 370 336 27 0 0 16 [[22, 335]] 1.0 5idn CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5XQXA 1 362 464.0 8CC:60402 Type1 Inactive DFGin 7.101 13.377 BLAminus -124.76, 173.54 67.85, 87.06 -93.65, 13.06 285.44, 142.36 -53.92, -30.2 in-in in 8.599 Saltbr-in 2.646 HRD-in -76.07, -52.85 74.84, 2.4 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.45 APE8-dihe-in -121.89, 118.59 APE8-rot-in 276.05 APE67-dihe-in -59.33, -23.95 -109.46, 21.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.009 None None None XRAY 2.3 0.19 0.222 A 380 337 25 0 0 13 [[22, 335]] 1.0 5xqx CMGC_CDK8_HUMAN CMGC 4.7e-82 281.6 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5XS2A 1 363 464.0 8D6:60402 Type1 Inactive DFGin 7.1 13.219 BLAminus -125.86, 168.92 68.44, 89.08 -85.59, 13.7 295.46, 132.91 -57.29, -23.08 in-in in 8.547 Saltbr-in 2.685 HRD-in -77.09, -53.4 74.45, 0.97 in-in-out SNCiio in-out ActLoopNT-in 2.725 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -119.34, 129.98 APE9-dihe-na -115.73, -15.25 APE8-dihe-in -128.4, 144.08 APE8-rot-out 53.94 APE67-dihe-in -59.75, -24.05 -125.87, 25.67 APE12-dist-in 7.138 APE11-dist-in 11.802 APE10-dist-out 9.847 APE9-dist-out 12.368 None None None XRAY 2.04 0.197 0.225 A 380 363 0 0 0 0 [[22, 335]] 1.0 5xs2 CMGC_CDK8_HUMAN CMGC 4.7e-82 281.6 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
6QTJA 1 359 464.0 JHK:60501 Type1 Inactive DFGin 7.586 14.075 BLAminus -112.22, -179.25 62.71, 86.71 -102.98, 13.61 301.92, 111.63 -83.54, 3.25 in-in in 8.461 Saltbr-in 2.937 HRD-in -68.14, -49.62 76.51, -6.19 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.96 APE8-dihe-in -121.23, 128.93 APE8-rot-in 272.12 APE67-dihe-in -58.17, -25.47 -117.92, 17.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.236 None None None XRAY 2.48 0.187 0.22 A 405 329 30 0 0 18 [[22, 335]] 1.0 6qtj CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
9H8CA 1 361 464.0 A1IS8:60503 Type1 Inactive DFGin 7.545 14.235 BLAminus -123.76, 163.44 68.83, 82.68 -94.14, 12.47 302.05, 120.29 -95.45, 18.7 in-in in 8.832 Saltbr-in 2.687 HRD-in -71.9, -45.8 76.46, -12.96 in-out-out SNCioo out-out ActLoopNT-out 8.836 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 1.06 APE8-dihe-in -111.33, 130.78 APE8-rot-in 270.85 APE67-dihe-in -58.13, -22.76 -124.23, 26.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.063 None None None XRAY 2.573 0.192 0.262 A 414 336 25 0 0 15 [[22, 335]] 1.0 9h8c CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
9H8SA 1 362 464.0 A1ITF:60509 Type1 Inactive DFGin 7.344 13.924 BLAminus -119.28, 163.44 74.84, 82.25 -92.61, 11.91 298.93, 132.0 -87.41, 10.8 in-in in 8.612 Saltbr-in 2.624 HRD-in -75.25, -51.5 79.06, -6.52 in-out-out SNCioo out-out ActLoopNT-out 8.659 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.05 APE8-rot-out 75.96 APE67-dihe-in -54.19, -23.95 -111.96, 19.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.157 0.197 0.248 A 414 335 27 0 0 17 [[22, 335]] 1.0 9h8s CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
8TQ2A 1 359 464.0 No_ligand No_ligand Inactive DFGin 5.953 13.409 BLAplus -149.38, -174.61 57.66, 42.3 -94.56, 56.63 80.28, 25.13 -65.65, -33.03 in-out in 9.074 Saltbr-out 5.018 HRD-in -71.17, -43.38 62.04, 12.67 out-in-out SNCoio in-out ActLoopNT-in 2.907 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.63, -27.07 APE9-dihe-na -152.97, 160.77 APE8-dihe-in -61.74, 149.93 APE8-rot-out 187.22 APE67-dihe-in -65.55, -27.76 -65.32, -15.56 APE12-dist-in 13.006 APE11-dist-in 10.604 APE10-dist-in 7.34 APE9-dist-in 4.231 None None None EM 3.8 999.0 999.0 A 464 313 46 0 0 0 [[22, 335]] 1.0 8tq2 CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
8TQCA 1 359 464.0 No_ligand No_ligand Inactive DFGin 5.954 13.41 BLAplus -149.38, -174.65 57.7, 42.3 -94.58, 56.63 80.22, 25.15 -65.67, -33.03 in-out in 9.074 Saltbr-out 5.017 HRD-in -71.16, -43.39 62.07, 12.66 out-in-out SNCoio in-out ActLoopNT-in 2.907 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.64, -27.07 APE9-dihe-na -152.99, 160.74 APE8-dihe-in -61.68, 149.91 APE8-rot-out 187.24 APE67-dihe-in -65.64, -27.68 -65.36, -15.51 APE12-dist-in 13.006 APE11-dist-in 10.604 APE10-dist-in 7.339 APE9-dist-in 4.231 None None None EM 3.8 999.0 999.0 A 464 313 46 0 0 0 [[22, 335]] 1.0 8tqc CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
8TQWA 1 359 464.0 No_ligand No_ligand Inactive DFGin 6.919 11.703 BLAplus -136.58, -174.19 58.52, 55.8 -94.53, 48.46 79.76, 124.7 -72.57, -22.17 in-out in 9.013 Saltbr-out 4.261 HRD-in -69.7, -41.94 60.18, 16.8 out-in-out SNCoio in-out ActLoopNT-in 3.224 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -107.3, -18.61 APE9-dihe-na -153.74, 161.23 APE8-dihe-in -65.82, 153.77 APE8-rot-out 180.15 APE67-dihe-in -67.85, -29.18 -70.07, -16.17 APE12-dist-in 12.764 APE11-dist-in 10.662 APE10-dist-in 7.085 APE9-dist-in 4.317 None None None EM 8.2 999.0 999.0 a 464 313 46 0 0 0 [[22, 335]] 1.0 8tqw CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
4G6LA 1 359 464.0 No_ligand No_ligand Inactive DFGin 7.782 13.165 BLBminus -140.33, 170.43 60.07, 39.76 -65.01, 139.84 287.11, 130.96 -72.68, 84.6 in-in in 9.41 Saltbr-in 2.732 HRD-in -90.39, -58.08 80.12, -10.69 in-out-none SNCion out-none ActLoopNT-out 8.791 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.75, -20.61 999.0, 14.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.214 0.266 A 406 333 26 0 0 12 [[22, 335]] 1.0 4g6l CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5FGKA 1 362 464.0 5XG:60401 Type1 Inactive DFGin 8.498 15.583 BLBminus -133.54, 169.31 57.53, 42.29 -55.85, 144.8 295.15, 85.37 -70.31, 91.66 in-in in 9.829 Saltbr-in 2.853 HRD-in -79.53, -56.66 86.65, -4.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.88 APE8-dihe-in -124.66, 135.5 APE8-rot-in 267.49 APE67-dihe-in -66.95, -24.09 -119.64, 24.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.946 None None None XRAY 2.36 999.0 0.237 A 364 331 31 0 0 17 [[22, 335]] 1.0 5fgk CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5HBEA 1 361 464.0 5Y6:60401 Type1 Inactive DFGin 6.382 13.48 BLBminus -150.55, 174.93 54.88, 46.99 -64.39, 138.78 282.35, 68.64 -73.7, 83.07 in-in in 9.475 Saltbr-in 2.663 HRD-in -80.78, -53.55 75.81, 1.36 in-out-out SNCioo out-out ActLoopNT-out 9.033 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 124.46 APE8-dihe-in -128.69, 136.48 APE8-rot-out 167.77 APE67-dihe-in -66.35, -22.41 -120.15, 22.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.377 None None None XRAY 2.38 0.23 0.256 A 364 343 18 0 0 9 [[22, 335]] 1.0 5hbe CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5HNBA 1 359 464.0 62M:60401 Type1 Inactive DFGin 6.65 13.171 BLBminus -138.74, 167.16 57.27, 44.77 -53.04, 139.99 284.36, 64.87 -77.11, 80.76 in-in in 9.352 Saltbr-in 2.7 HRD-in -81.89, -52.43 75.49, 2.56 in-out-out SNCioo out-out ActLoopNT-out 8.874 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 22.41 APE8-rot-in 326.4 APE67-dihe-out -68.33, -25.9 68.06, 1.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.35 0.218 0.252 A 370 339 20 0 0 10 [[22, 335]] 1.0 5hnb CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5I5ZA 1 362 464.0 68U:60401 Type1 Inactive DFGin 6.415 13.064 BLBminus -146.19, 175.23 51.04, 37.29 -51.44, 128.07 281.53, 66.91 -69.5, 65.99 in-in in 9.115 Saltbr-in 2.902 HRD-in -79.94, -54.75 78.35, 1.56 in-out-out SNCioo out-out ActLoopNT-out 8.79 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 116.55 APE8-rot-out 180.69 APE67-dihe-in -62.72, -27.98 -92.64, 5.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.239 0.274 A 370 342 20 0 0 10 [[22, 335]] 1.0 5i5z CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5IDPA 1 359 464.0 6A6:60401 Type1 Inactive DFGin 6.659 13.118 BLBminus -136.27, 172.07 59.2, 45.18 -61.59, 132.52 281.19, 68.65 -74.88, 80.04 in-in in 9.393 Saltbr-in 2.897 HRD-in -79.39, -54.81 77.61, 1.02 in-out-out SNCioo out-out ActLoopNT-out 8.694 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 164.27 APE8-rot-out 60.39 APE67-dihe-in -68.82, -22.92 -114.95, 18.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.232 0.272 A 370 341 18 0 0 10 [[22, 335]] 1.0 5idp CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
4F7SA 1 359 464.0 0SW:60501 Type1 Inactive DFGin 6.495 13.069 BLBminus -136.61, 176.12 53.35, 42.37 -54.98, 136.0 280.12, 74.29 -77.21, 78.52 in-in in 9.229 Saltbr-in 2.747 HRD-in -79.34, -55.77 76.41, 2.24 in-out-out SNCioo out-out ActLoopNT-out 8.76 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.9 APE8-rot-out 180.5 APE67-dihe-in -68.08, -24.25 -110.68, 14.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.194 0.222 A 405 339 20 0 0 9 [[22, 335]] 1.0 4f7s CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5BNJA 1 362 464.0 4TV:60501 Type1 Inactive DFGin 6.2 14.613 BLBminus -127.23, 163.17 60.48, 55.04 -65.81, 148.47 290.88, 72.47 -70.37, 93.4 in-in in 9.812 Saltbr-in 2.728 HRD-in -79.48, -50.1 76.1, -2.58 in-out-out SNCioo out-out ActLoopNT-out 8.736 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 162.07 APE8-rot-out 56.78 APE67-dihe-in -68.21, -22.51 -112.22, 14.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.64 0.228 0.273 A 405 341 21 0 0 11 [[22, 335]] 1.0 5bnj CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
6QTGA 1 359 464.0 JH8:60501 Type1 Inactive DFGin 6.855 13.598 BLBminus -115.69, 168.8 67.93, 119.69 -128.98, 119.87 314.23, 115.38 -156.88, 999.0 in-in in 8.458 Saltbr-in 2.944 HRD-in -69.43, -47.54 81.38, -19.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -47.73 APE8-dihe-in -122.24, 124.81 APE8-rot-in 266.36 APE67-dihe-in -67.96, -18.93 -113.56, 25.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.068 None None None XRAY 2.7 0.202 0.231 A 405 328 31 0 0 19 [[22, 335]] 1.0 6qtg CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
4CRLA 1 359 464.0 C1I:61360 Type1 Inactive DFGin 6.263 12.965 BLBminus -130.84, 167.17 41.28, 61.34 -57.58, 143.29 285.19, 53.46 -56.15, 77.43 in-in in 9.278 Saltbr-in 2.765 HRD-in -77.87, -48.76 70.82, 12.4 in-out-out SNCioo out-out ActLoopNT-out 8.829 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -12.95 APE8-dihe-in -65.77, 114.52 APE8-rot-out 186.25 APE67-dihe-in -70.31, -18.88 -108.2, 7.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.355 None None None XRAY 2.4 0.201 0.256 A 406 336 23 0 0 10 [[22, 335]] 1.0 4crl CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5CEIA 1 362 464.0 50R:60508 Type1 Inactive DFGin 6.433 13.015 BLBminus -132.66, 174.92 55.78, 44.71 -56.21, 137.6 280.16, 70.73 -77.01, 72.68 in-in in 9.28 Saltbr-in 2.579 HRD-in -79.82, -54.28 77.75, 0.99 in-out-out SNCioo out-out ActLoopNT-out 8.663 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 169.41 APE8-rot-out 67.16 APE67-dihe-in -60.87, -22.55 -115.47, 18.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.24 0.175 0.227 A 406 344 18 0 0 9 [[22, 335]] 1.0 5cei CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
6R3SA 1 362 464.0 JRE:60501 Type1 Inactive DFGin 6.449 13.117 BLBminus -136.26, 169.85 57.34, 42.45 -52.43, 144.8 287.58, 63.16 -78.12, 79.2 in-in in 9.376 Saltbr-in 2.83 HRD-in -80.26, -51.73 75.92, 4.6 in-out-out SNCioo out-out ActLoopNT-out 8.688 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.83 APE8-rot-out 181.78 APE67-dihe-in -67.95, -25.35 -103.82, 11.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.19 0.202 0.227 A 406 343 19 0 0 9 [[22, 335]] 1.0 6r3s CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
6Y0AA 1 362 464.0 JRE:60501 Type1 Inactive DFGin 6.449 13.117 BLBminus -136.26, 169.85 57.34, 42.45 -52.43, 144.8 287.58, 63.16 -78.12, 79.2 in-in in 9.376 Saltbr-in 2.83 HRD-in -80.26, -51.73 75.92, 4.6 in-out-out SNCioo out-out ActLoopNT-out 8.688 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.83 APE8-rot-out 181.78 APE67-dihe-in -67.95, -25.35 -103.82, 11.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.19 0.202 0.227 A 406 343 19 0 0 9 [[22, 335]] 1.0 6y0a CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
6T41A 1 359 464.0 MFE:60501 Type1 Inactive DFGin 8.63 13.515 BLBminus -130.72, 167.87 65.4, 35.77 -47.77, 142.68 290.97, 94.77 -79.52, 87.36 in-in in 9.226 Saltbr-in 2.967 HRD-in -82.44, -61.41 81.57, -4.44 in-out-out SNCioo out-out ActLoopNT-out 8.875 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 161.03 APE8-rot-out 58.35 APE67-dihe-in -69.81, -18.57 -101.28, 19.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.185 0.256 A 407 343 16 0 0 9 [[22, 335]] 1.0 6t41 CMGC_CDK8_HUMAN CMGC 6e-82 281.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5HBHA 1 361 464.0 5Y7:60401 Type1 Inactive DFGin 5.484 13.336 BLBplus -129.14, 169.91 65.09, 34.73 -89.33, 139.59 54.15, 87.69 88.57, 16.73 in-in in 9.144 Saltbr-in 2.841 HRD-in -73.61, -55.97 88.78, -11.96 in-out-out SNCioo out-out ActLoopNT-out 9.652 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 146.42 APE9-dihe-na -93.82, 144.5 APE8-dihe-in -120.03, 143.32 APE8-rot-out 75.1 APE67-dihe-in -65.56, -22.05 -107.02, 22.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.842 APE9-dist-out 12.185 None None None XRAY 2.5 0.235 0.268 A 364 334 27 0 0 14 [[22, 335]] 1.0 5hbh CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
3RGFA 1 353 464.0 BAX:60465 Type2 Inactive DFGout 15.09 10.864 BBAminus -128.79, 167.92 -135.88, 84.21 -83.29, -7.22 304.7, 18.84 -121.06, 44.25 in-out in 9.37 Saltbr-out 4.852 HRD-in -76.1, -55.23 78.73, 2.83 out-out-out SNCooo out-out ActLoopNT-out 12.224 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 133.12 APE8-dihe-in -111.84, 132.17 APE8-rot-out 185.32 APE67-dihe-in -67.42, -19.98 -109.35, 18.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.637 None None None XRAY 2.2 0.183 0.221 A 405 319 34 0 0 16 [[22, 335]] 1.0 3rgf CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
4F6UA 1 359 464.0 0SR:60501 Type2 Inactive DFGout 14.529 8.147 BBAminus -137.04, 173.39 -132.48, 97.94 -82.11, -23.16 303.07, 124.54 89.51, -145.66 in-in in 8.527 Saltbr-in 2.627 HRD-in -75.69, -54.68 80.97, 0.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, -48.5 APE9-dihe-na -168.88, 136.11 APE8-dihe-in -116.43, 154.29 APE8-rot-out 81.86 APE67-dihe-in -65.37, -20.81 -106.87, 16.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.233 APE9-dist-out 10.942 None None None XRAY 2.1 0.177 0.198 A 405 332 27 0 0 17 [[22, 335]] 1.0 4f6u CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
4F6WA 1 359 464.0 0SS:60501 Type2 Inactive DFGout 17.045 13.947 BBAminus -134.04, 175.74 -149.99, 134.58 -80.54, -17.82 302.37, 168.31 89.71, 32.24 in-in in 8.523 Saltbr-in 2.665 HRD-in -81.35, -56.06 84.43, -4.37 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 94.48 APE8-rot-in 298.45 APE67-dihe-in -64.37, -22.4 -100.8, 19.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.193 0.234 A 405 330 29 0 0 18 [[22, 335]] 1.0 4f6w CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
4F7LA 1 359 464.0 0SO:60501 Type2 Inactive DFGout 13.543 10.487 BBAminus -144.39, 166.94 -130.48, 125.05 -101.12, -66.88 314.21, 89.91 174.94, 999.0 in-in in 9.053 Saltbr-in 2.73 HRD-in -72.87, -46.64 81.38, -4.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.76 APE8-rot-out 66.51 APE67-dihe-in -72.52, -24.41 -123.27, 25.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.226 0.27 A 405 326 33 0 0 20 [[22, 335]] 1.0 4f7l CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
4F7NA 1 361 464.0 0SV:60501 Type2 Inactive DFGout 14.194 8.21 BBAminus -139.77, 176.54 -136.01, 97.7 -86.48, -26.06 306.23, 126.32 100.15, -136.94 in-in in 8.78 Saltbr-in 2.786 HRD-in -78.13, -54.62 75.98, 5.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, 43.71 APE9-dihe-na -114.3, 132.58 APE8-dihe-in -127.74, 146.12 APE8-rot-out 68.03 APE67-dihe-in -66.61, -22.51 -99.38, 17.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.82 APE9-dist-out 11.271 None None None XRAY 2.65 0.2 0.228 A 405 333 28 0 0 17 [[22, 335]] 1.0 4f7n CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
5HVYA 1 359 464.0 66X:60501 Type2 Inactive DFGout 15.175 9.312 BBAminus -147.75, 175.04 -130.64, 103.81 -80.2, 9.83 305.77, 118.03 84.07, 29.62 out-out out 11.267 Saltbr-out 6.112 HRD-in -85.57, -56.75 82.18, -2.99 out-out-out SNCooo out-out ActLoopNT-out 12.861 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -86.7, 132.16 APE9-dihe-na -171.76, 167.74 APE8-dihe-in -116.95, 139.23 APE8-rot-out 61.83 APE67-dihe-in -58.0, -28.58 -98.28, 0.53 APE12-dist-out 14.371 APE11-dist-in 9.032 APE10-dist-out 8.299 APE9-dist-out 10.379 None None None XRAY 2.39 0.181 0.22 A 406 333 26 0 0 12 [[22, 335]] 1.0 5hvy CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
6TPAA 1 359 464.0 NZ8:60501,NZ5:60505,NZ5:60506,NZ5:60507 Type2,Allosteric,Allosteric,Allosteric Inactive DFGout 13.832 11.818 BBAminus -130.48, -178.36 -144.36, 91.14 -84.2, -4.16 322.15, 13.04 -124.91, 44.75 out-out out 10.182 Saltbr-out 4.955 HRD-in -82.95, -50.83 78.95, 15.78 out-out-out SNCooo out-out ActLoopNT-out 11.908 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.19 APE8-rot-out 87.86 APE67-dihe-in -63.33, -23.46 -113.41, 27.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.228 0.264 A 405 334 25 0 0 16 [[22, 335]] 1.0 6tpa CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
4F6SA 1 359 464.0 0SQ:60501 Type3 Inactive DFGout 13.878 7.557 BBAminus -143.37, 174.31 -133.59, 95.54 -89.33, -12.55 298.0, 127.79 85.97, -154.1 in-in in 8.67 Saltbr-in 2.813 HRD-in -74.89, -55.83 78.59, -0.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.84 APE8-dihe-in -132.11, 155.15 APE8-rot-out 82.42 APE67-dihe-in -62.47, -25.65 -106.71, 17.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.87 None None None XRAY 2.6 0.205 0.26 A 405 327 32 0 0 17 [[22, 335]] 1.0 4f6s CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
4F7JA 1 359 464.0 0SU:60501 Type3 Inactive DFGout 14.423 8.595 BBAminus -131.55, -173.38 -148.17, 95.28 -72.43, -38.8 311.88, 131.51 104.34, -133.92 in-in in 8.724 Saltbr-in 2.664 HRD-in -75.51, -51.42 85.3, -13.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.87 APE8-dihe-in -70.46, 100.26 APE8-rot-in 296.32 APE67-dihe-in -60.95, -26.84 -87.97, 10.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.055 None None None XRAY 2.6 0.229 0.276 A 405 326 33 0 0 18 [[22, 335]] 1.0 4f7j CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
4F70A 1 359 464.0 0ST:60501 Type3 Inactive None 18.647 14.421 None -123.12, -177.92 -154.05, 113.27 -90.85, 999.0 75.63, 12.09 999.0, 999.0 in-in in 8.993 Saltbr-in 3.008 HRD-in -82.85, -48.58 74.91, -2.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 73.37 APE8-dihe-in -133.51, 141.85 APE8-rot-out 58.33 APE67-dihe-in -73.19, -29.13 -108.0, 28.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.562 None None None XRAY 3.0 0.204 0.239 A 405 326 33 0 0 20 [[22, 335]] 1.0 4f70 CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8

CMGC_CDK8 (Cyclin-dependent kinase 8)

Total number of chains: 38
Active chains: 2
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 14 36.8% 6T41A
DFGin BLAminus 10 26.3% AF-P49336-K1A
DFGout BBAminus 9 23.7% 6TPAA
DFGin BLAplus 3 7.9% 8TQ2A
DFGin BLBplus 1 2.6% 5HBHA
None None 1 2.6% 4F70A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK8_HUMAN AF-P49336-K1A P49336 12 343 464.0 No_ligand No_ligand Active DFGin 6.931 15.663 BLAminus -128.17, 177.28 55.68, 59.43 -72.54, 15.56 300.04, 114.68 -62.04, -32.39 in-in in 9.165 Saltbr-in 2.897 HRD-in -73.5, -51.19 62.86, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.05, 164.39 APE9-dihe-na 83.32, 124.4 APE8-dihe-in -52.27, 134.37 APE8-rot-in 287.61 APE67-dihe-in -65.17, -26.48 -44.23, -41.35 APE12-dist-in 12.059 APE11-dist-in 11.607 APE10-dist-in 5.808 APE9-dist-in 3.409 None None None AF2 -1.0 1.0 1.0 A 332 332 0 0 0 0 [[22, 335]] 1.0 AF-P49336-K1 Homo sapiens CMGC_CDK8_HUMAN CMGC 2.9e-82 282.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN AF-P49336-K3A P49336 12 343 464.0 No_ligand No_ligand Active DFGin 7.059 14.415 BLAminus -125.11, 179.05 58.06, 66.16 -75.42, 13.63 298.43, 116.53 -58.59, -38.0 in-in in 9.222 Saltbr-in 2.72 HRD-in -77.81, -49.38 63.32, 9.66 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.07, 166.88 APE9-dihe-na 60.71, 128.33 APE8-dihe-in -54.75, 135.42 APE8-rot-in 297.36 APE67-dihe-in -67.37, -15.46 -44.59, -50.0 APE12-dist-in 12.561 APE11-dist-in 10.811 APE10-dist-in 6.581 APE9-dist-in 3.286 None None None AF2 -1.0 1.0 1.0 A 332 332 0 0 0 0 [[22, 335]] 1.0 AF-P49336-K3 Homo sapiens CMGC_CDK8_HUMAN CMGC 2.9e-82 282.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5HBJA P49336 1 361 464.0 5Y8:60401 Type1 Inactive DFGin 7.542 14.779 BLAminus -106.87, 176.98 71.07, 89.31 -114.96, 61.9 305.41, 118.79 -100.84, -170.16 in-in in 9.761 Saltbr-in 2.682 HRD-in -77.67, -52.92 73.2, 5.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -16.09 APE8-dihe-in -117.57, 98.85 APE8-rot-in 304.83 APE67-dihe-in -72.47, -22.93 -102.77, 29.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.378 None None None XRAY 3.0 999.0 0.288 A 364 340 21 0 0 12 [[22, 335]] 1.0 5hbj Homo sapiens CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5ICPA P49336 1 362 464.0 69Z:60401 Type1 Inactive DFGin 6.147 13.639 BLAminus -129.39, 179.13 50.41, 56.76 -66.42, 4.81 256.2, 78.89 56.91, 53.37 in-in in 9.19 Saltbr-in 2.587 HRD-in -78.65, -54.95 77.97, -2.02 in-out-out SNCioo out-out ActLoopNT-out 8.789 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 83.07 APE9-dihe-na -127.02, 140.47 APE8-dihe-in -112.3, 142.07 APE8-rot-out 57.72 APE67-dihe-in -65.52, -25.52 -110.98, 18.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.684 APE9-dist-out 12.509 None None None XRAY 2.18 0.185 0.216 A 364 343 19 0 0 8 [[22, 335]] 1.0 5icp Homo sapiens CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5IDNA P49336 1 363 464.0 6A7:60401 Type1 Inactive DFGin 7.323 16.088 BLAminus -124.47, 174.0 67.51, 75.48 -91.55, 21.99 294.62, 123.1 -96.7, 0.53 in-in in 8.97 Saltbr-in 2.647 HRD-in -71.0, -49.83 80.54, -0.94 in-out-out SNCioo out-out ActLoopNT-out 8.405 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.78 APE8-dihe-in -125.68, 150.04 APE8-rot-out 46.55 APE67-dihe-in -67.71, -25.83 -125.87, 33.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.773 None None None XRAY 2.26 0.221 0.253 A 370 336 27 0 0 16 [[22, 335]] 1.0 5idn Homo sapiens CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5XQXA P49336 1 362 464.0 8CC:60402 Type1 Inactive DFGin 7.101 13.377 BLAminus -124.76, 173.54 67.85, 87.06 -93.65, 13.06 285.44, 142.36 -53.92, -30.2 in-in in 8.599 Saltbr-in 2.646 HRD-in -76.07, -52.85 74.84, 2.4 in-in-out SNCiio in-out ActLoopNT-in 2.797 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.45 APE8-dihe-in -121.89, 118.59 APE8-rot-in 276.05 APE67-dihe-in -59.33, -23.95 -109.46, 21.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.009 None None None XRAY 2.3 0.19 0.222 A 380 337 25 0 0 13 [[22, 335]] 1.0 5xqx Homo sapiens CMGC_CDK8_HUMAN CMGC 4.7e-82 281.6 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5XS2A P49336 1 363 464.0 8D6:60402 Type1 Inactive DFGin 7.1 13.219 BLAminus -125.86, 168.92 68.44, 89.08 -85.59, 13.7 295.46, 132.91 -57.29, -23.08 in-in in 8.547 Saltbr-in 2.685 HRD-in -77.09, -53.4 74.45, 0.97 in-in-out SNCiio in-out ActLoopNT-in 2.725 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -119.34, 129.98 APE9-dihe-na -115.73, -15.25 APE8-dihe-in -128.4, 144.08 APE8-rot-out 53.94 APE67-dihe-in -59.75, -24.05 -125.87, 25.67 APE12-dist-in 7.138 APE11-dist-in 11.802 APE10-dist-out 9.847 APE9-dist-out 12.368 None None None XRAY 2.04 0.197 0.225 A 380 363 0 0 0 0 [[22, 335]] 1.0 5xs2 Homo sapiens CMGC_CDK8_HUMAN CMGC 4.7e-82 281.6 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 6QTJA P49336 1 359 464.0 JHK:60501 Type1 Inactive DFGin 7.586 14.075 BLAminus -112.22, -179.25 62.71, 86.71 -102.98, 13.61 301.92, 111.63 -83.54, 3.25 in-in in 8.461 Saltbr-in 2.937 HRD-in -68.14, -49.62 76.51, -6.19 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.96 APE8-dihe-in -121.23, 128.93 APE8-rot-in 272.12 APE67-dihe-in -58.17, -25.47 -117.92, 17.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.236 None None None XRAY 2.48 0.187 0.22 A 405 329 30 0 0 18 [[22, 335]] 1.0 6qtj Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 9H8CA P49336 1 361 464.0 A1IS8:60503 Type1 Inactive DFGin 7.545 14.235 BLAminus -123.76, 163.44 68.83, 82.68 -94.14, 12.47 302.05, 120.29 -95.45, 18.7 in-in in 8.832 Saltbr-in 2.687 HRD-in -71.9, -45.8 76.46, -12.96 in-out-out SNCioo out-out ActLoopNT-out 8.836 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 1.06 APE8-dihe-in -111.33, 130.78 APE8-rot-in 270.85 APE67-dihe-in -58.13, -22.76 -124.23, 26.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.063 None None None XRAY 2.573 0.192 0.262 A 414 336 25 0 0 15 [[22, 335]] 1.0 9h8c Homo sapiens CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 9H8SA P49336 1 362 464.0 A1ITF:60509 Type1 Inactive DFGin 7.344 13.924 BLAminus -119.28, 163.44 74.84, 82.25 -92.61, 11.91 298.93, 132.0 -87.41, 10.8 in-in in 8.612 Saltbr-in 2.624 HRD-in -75.25, -51.5 79.06, -6.52 in-out-out SNCioo out-out ActLoopNT-out 8.659 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.05 APE8-rot-out 75.96 APE67-dihe-in -54.19, -23.95 -111.96, 19.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.157 0.197 0.248 A 414 335 27 0 0 17 [[22, 335]] 1.0 9h8s Homo sapiens CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 8TQ2A P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 5.953 13.409 BLAplus -149.38, -174.61 57.66, 42.3 -94.56, 56.63 80.28, 25.13 -65.65, -33.03 in-out in 9.074 Saltbr-out 5.018 HRD-in -71.17, -43.38 62.04, 12.67 out-in-out SNCoio in-out ActLoopNT-in 2.907 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.63, -27.07 APE9-dihe-na -152.97, 160.77 APE8-dihe-in -61.74, 149.93 APE8-rot-out 187.22 APE67-dihe-in -65.55, -27.76 -65.32, -15.56 APE12-dist-in 13.006 APE11-dist-in 10.604 APE10-dist-in 7.34 APE9-dist-in 4.231 None None None EM 3.8 999.0 999.0 A 464 313 46 0 0 0 [[22, 335]] 1.0 8tq2 Homo sapiens CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 8TQCA P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 5.954 13.41 BLAplus -149.38, -174.65 57.7, 42.3 -94.58, 56.63 80.22, 25.15 -65.67, -33.03 in-out in 9.074 Saltbr-out 5.017 HRD-in -71.16, -43.39 62.07, 12.66 out-in-out SNCoio in-out ActLoopNT-in 2.907 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.64, -27.07 APE9-dihe-na -152.99, 160.74 APE8-dihe-in -61.68, 149.91 APE8-rot-out 187.24 APE67-dihe-in -65.64, -27.68 -65.36, -15.51 APE12-dist-in 13.006 APE11-dist-in 10.604 APE10-dist-in 7.339 APE9-dist-in 4.231 None None None EM 3.8 999.0 999.0 A 464 313 46 0 0 0 [[22, 335]] 1.0 8tqc Homo sapiens CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 8TQWA P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 6.919 11.703 BLAplus -136.58, -174.19 58.52, 55.8 -94.53, 48.46 79.76, 124.7 -72.57, -22.17 in-out in 9.013 Saltbr-out 4.261 HRD-in -69.7, -41.94 60.18, 16.8 out-in-out SNCoio in-out ActLoopNT-in 3.224 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -107.3, -18.61 APE9-dihe-na -153.74, 161.23 APE8-dihe-in -65.82, 153.77 APE8-rot-out 180.15 APE67-dihe-in -67.85, -29.18 -70.07, -16.17 APE12-dist-in 12.764 APE11-dist-in 10.662 APE10-dist-in 7.085 APE9-dist-in 4.317 None None None EM 8.2 999.0 999.0 a 464 313 46 0 0 0 [[22, 335]] 1.0 8tqw Homo sapiens CMGC_CDK8_HUMAN CMGC 9.1e-82 280.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 4G6LA P49336 1 359 464.0 No_ligand No_ligand Inactive DFGin 7.782 13.165 BLBminus -140.33, 170.43 60.07, 39.76 -65.01, 139.84 287.11, 130.96 -72.68, 84.6 in-in in 9.41 Saltbr-in 2.732 HRD-in -90.39, -58.08 80.12, -10.69 in-out-none SNCion out-none ActLoopNT-out 8.791 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.75, -20.61 999.0, 14.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.214 0.266 A 406 333 26 0 0 12 [[22, 335]] 1.0 4g6l Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5FGKA P49336 1 362 464.0 5XG:60401 Type1 Inactive DFGin 8.498 15.583 BLBminus -133.54, 169.31 57.53, 42.29 -55.85, 144.8 295.15, 85.37 -70.31, 91.66 in-in in 9.829 Saltbr-in 2.853 HRD-in -79.53, -56.66 86.65, -4.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.88 APE8-dihe-in -124.66, 135.5 APE8-rot-in 267.49 APE67-dihe-in -66.95, -24.09 -119.64, 24.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.946 None None None XRAY 2.36 999.0 0.237 A 364 331 31 0 0 17 [[22, 335]] 1.0 5fgk Homo sapiens CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5HBEA P49336 1 361 464.0 5Y6:60401 Type1 Inactive DFGin 6.382 13.48 BLBminus -150.55, 174.93 54.88, 46.99 -64.39, 138.78 282.35, 68.64 -73.7, 83.07 in-in in 9.475 Saltbr-in 2.663 HRD-in -80.78, -53.55 75.81, 1.36 in-out-out SNCioo out-out ActLoopNT-out 9.033 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 124.46 APE8-dihe-in -128.69, 136.48 APE8-rot-out 167.77 APE67-dihe-in -66.35, -22.41 -120.15, 22.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.377 None None None XRAY 2.38 0.23 0.256 A 364 343 18 0 0 9 [[22, 335]] 1.0 5hbe Homo sapiens CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5HNBA P49336 1 359 464.0 62M:60401 Type1 Inactive DFGin 6.65 13.171 BLBminus -138.74, 167.16 57.27, 44.77 -53.04, 139.99 284.36, 64.87 -77.11, 80.76 in-in in 9.352 Saltbr-in 2.7 HRD-in -81.89, -52.43 75.49, 2.56 in-out-out SNCioo out-out ActLoopNT-out 8.874 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 22.41 APE8-rot-in 326.4 APE67-dihe-out -68.33, -25.9 68.06, 1.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.35 0.218 0.252 A 370 339 20 0 0 10 [[22, 335]] 1.0 5hnb Homo sapiens CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5I5ZA P49336 1 362 464.0 68U:60401 Type1 Inactive DFGin 6.415 13.064 BLBminus -146.19, 175.23 51.04, 37.29 -51.44, 128.07 281.53, 66.91 -69.5, 65.99 in-in in 9.115 Saltbr-in 2.902 HRD-in -79.94, -54.75 78.35, 1.56 in-out-out SNCioo out-out ActLoopNT-out 8.79 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 116.55 APE8-rot-out 180.69 APE67-dihe-in -62.72, -27.98 -92.64, 5.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.239 0.274 A 370 342 20 0 0 10 [[22, 335]] 1.0 5i5z Homo sapiens CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5IDPA P49336 1 359 464.0 6A6:60401 Type1 Inactive DFGin 6.659 13.118 BLBminus -136.27, 172.07 59.2, 45.18 -61.59, 132.52 281.19, 68.65 -74.88, 80.04 in-in in 9.393 Saltbr-in 2.897 HRD-in -79.39, -54.81 77.61, 1.02 in-out-out SNCioo out-out ActLoopNT-out 8.694 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 164.27 APE8-rot-out 60.39 APE67-dihe-in -68.82, -22.92 -114.95, 18.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.232 0.272 A 370 341 18 0 0 10 [[22, 335]] 1.0 5idp Homo sapiens CMGC_CDK8_HUMAN CMGC 4.3e-82 281.7 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 4F7SA P49336 1 359 464.0 0SW:60501 Type1 Inactive DFGin 6.495 13.069 BLBminus -136.61, 176.12 53.35, 42.37 -54.98, 136.0 280.12, 74.29 -77.21, 78.52 in-in in 9.229 Saltbr-in 2.747 HRD-in -79.34, -55.77 76.41, 2.24 in-out-out SNCioo out-out ActLoopNT-out 8.76 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.9 APE8-rot-out 180.5 APE67-dihe-in -68.08, -24.25 -110.68, 14.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.194 0.222 A 405 339 20 0 0 9 [[22, 335]] 1.0 4f7s Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5BNJA P49336 1 362 464.0 4TV:60501 Type1 Inactive DFGin 6.2 14.613 BLBminus -127.23, 163.17 60.48, 55.04 -65.81, 148.47 290.88, 72.47 -70.37, 93.4 in-in in 9.812 Saltbr-in 2.728 HRD-in -79.48, -50.1 76.1, -2.58 in-out-out SNCioo out-out ActLoopNT-out 8.736 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 162.07 APE8-rot-out 56.78 APE67-dihe-in -68.21, -22.51 -112.22, 14.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.64 0.228 0.273 A 405 341 21 0 0 11 [[22, 335]] 1.0 5bnj Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 6QTGA P49336 1 359 464.0 JH8:60501 Type1 Inactive DFGin 6.855 13.598 BLBminus -115.69, 168.8 67.93, 119.69 -128.98, 119.87 314.23, 115.38 -156.88, 999.0 in-in in 8.458 Saltbr-in 2.944 HRD-in -69.43, -47.54 81.38, -19.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -47.73 APE8-dihe-in -122.24, 124.81 APE8-rot-in 266.36 APE67-dihe-in -67.96, -18.93 -113.56, 25.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.068 None None None XRAY 2.7 0.202 0.231 A 405 328 31 0 0 19 [[22, 335]] 1.0 6qtg Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 4CRLA P49336 1 359 464.0 C1I:61360 Type1 Inactive DFGin 6.263 12.965 BLBminus -130.84, 167.17 41.28, 61.34 -57.58, 143.29 285.19, 53.46 -56.15, 77.43 in-in in 9.278 Saltbr-in 2.765 HRD-in -77.87, -48.76 70.82, 12.4 in-out-out SNCioo out-out ActLoopNT-out 8.829 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -12.95 APE8-dihe-in -65.77, 114.52 APE8-rot-out 186.25 APE67-dihe-in -70.31, -18.88 -108.2, 7.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.355 None None None XRAY 2.4 0.201 0.256 A 406 336 23 0 0 10 [[22, 335]] 1.0 4crl Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5CEIA P49336 1 362 464.0 50R:60508 Type1 Inactive DFGin 6.433 13.015 BLBminus -132.66, 174.92 55.78, 44.71 -56.21, 137.6 280.16, 70.73 -77.01, 72.68 in-in in 9.28 Saltbr-in 2.579 HRD-in -79.82, -54.28 77.75, 0.99 in-out-out SNCioo out-out ActLoopNT-out 8.663 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 169.41 APE8-rot-out 67.16 APE67-dihe-in -60.87, -22.55 -115.47, 18.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.24 0.175 0.227 A 406 344 18 0 0 9 [[22, 335]] 1.0 5cei Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 6R3SA P49336 1 362 464.0 JRE:60501 Type1 Inactive DFGin 6.449 13.117 BLBminus -136.26, 169.85 57.34, 42.45 -52.43, 144.8 287.58, 63.16 -78.12, 79.2 in-in in 9.376 Saltbr-in 2.83 HRD-in -80.26, -51.73 75.92, 4.6 in-out-out SNCioo out-out ActLoopNT-out 8.688 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.83 APE8-rot-out 181.78 APE67-dihe-in -67.95, -25.35 -103.82, 11.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.19 0.202 0.227 A 406 343 19 0 0 9 [[22, 335]] 1.0 6r3s Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 6Y0AA P49336 1 362 464.0 JRE:60501 Type1 Inactive DFGin 6.449 13.117 BLBminus -136.26, 169.85 57.34, 42.45 -52.43, 144.8 287.58, 63.16 -78.12, 79.2 in-in in 9.376 Saltbr-in 2.83 HRD-in -80.26, -51.73 75.92, 4.6 in-out-out SNCioo out-out ActLoopNT-out 8.688 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.83 APE8-rot-out 181.78 APE67-dihe-in -67.95, -25.35 -103.82, 11.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.19 0.202 0.227 A 406 343 19 0 0 9 [[22, 335]] 1.0 6y0a Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 6T41A P49336 1 359 464.0 MFE:60501 Type1 Inactive DFGin 8.63 13.515 BLBminus -130.72, 167.87 65.4, 35.77 -47.77, 142.68 290.97, 94.77 -79.52, 87.36 in-in in 9.226 Saltbr-in 2.967 HRD-in -82.44, -61.41 81.57, -4.44 in-out-out SNCioo out-out ActLoopNT-out 8.875 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 161.03 APE8-rot-out 58.35 APE67-dihe-in -69.81, -18.57 -101.28, 19.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.185 0.256 A 407 343 16 0 0 9 [[22, 335]] 1.0 6t41 Homo sapiens CMGC_CDK8_HUMAN CMGC 6e-82 281.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5HBHA P49336 1 361 464.0 5Y7:60401 Type1 Inactive DFGin 5.484 13.336 BLBplus -129.14, 169.91 65.09, 34.73 -89.33, 139.59 54.15, 87.69 88.57, 16.73 in-in in 9.144 Saltbr-in 2.841 HRD-in -73.61, -55.97 88.78, -11.96 in-out-out SNCioo out-out ActLoopNT-out 9.652 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 146.42 APE9-dihe-na -93.82, 144.5 APE8-dihe-in -120.03, 143.32 APE8-rot-out 75.1 APE67-dihe-in -65.56, -22.05 -107.02, 22.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.842 APE9-dist-out 12.185 None None None XRAY 2.5 0.235 0.268 A 364 334 27 0 0 14 [[22, 335]] 1.0 5hbh Homo sapiens CMGC_CDK8_HUMAN CMGC 4.1e-82 281.8 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 3RGFA P49336 1 353 464.0 BAX:60465 Type2 Inactive DFGout 15.09 10.864 BBAminus -128.79, 167.92 -135.88, 84.21 -83.29, -7.22 304.7, 18.84 -121.06, 44.25 in-out in 9.37 Saltbr-out 4.852 HRD-in -76.1, -55.23 78.73, 2.83 out-out-out SNCooo out-out ActLoopNT-out 12.224 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 133.12 APE8-dihe-in -111.84, 132.17 APE8-rot-out 185.32 APE67-dihe-in -67.42, -19.98 -109.35, 18.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.637 None None None XRAY 2.2 0.183 0.221 A 405 319 34 0 0 16 [[22, 335]] 1.0 3rgf Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 4F6UA P49336 1 359 464.0 0SR:60501 Type2 Inactive DFGout 14.529 8.147 BBAminus -137.04, 173.39 -132.48, 97.94 -82.11, -23.16 303.07, 124.54 89.51, -145.66 in-in in 8.527 Saltbr-in 2.627 HRD-in -75.69, -54.68 80.97, 0.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, -48.5 APE9-dihe-na -168.88, 136.11 APE8-dihe-in -116.43, 154.29 APE8-rot-out 81.86 APE67-dihe-in -65.37, -20.81 -106.87, 16.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.233 APE9-dist-out 10.942 None None None XRAY 2.1 0.177 0.198 A 405 332 27 0 0 17 [[22, 335]] 1.0 4f6u Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 4F6WA P49336 1 359 464.0 0SS:60501 Type2 Inactive DFGout 17.045 13.947 BBAminus -134.04, 175.74 -149.99, 134.58 -80.54, -17.82 302.37, 168.31 89.71, 32.24 in-in in 8.523 Saltbr-in 2.665 HRD-in -81.35, -56.06 84.43, -4.37 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 94.48 APE8-rot-in 298.45 APE67-dihe-in -64.37, -22.4 -100.8, 19.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.193 0.234 A 405 330 29 0 0 18 [[22, 335]] 1.0 4f6w Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 4F7LA P49336 1 359 464.0 0SO:60501 Type2 Inactive DFGout 13.543 10.487 BBAminus -144.39, 166.94 -130.48, 125.05 -101.12, -66.88 314.21, 89.91 174.94, 999.0 in-in in 9.053 Saltbr-in 2.73 HRD-in -72.87, -46.64 81.38, -4.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.76 APE8-rot-out 66.51 APE67-dihe-in -72.52, -24.41 -123.27, 25.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.226 0.27 A 405 326 33 0 0 20 [[22, 335]] 1.0 4f7l Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 4F7NA P49336 1 361 464.0 0SV:60501 Type2 Inactive DFGout 14.194 8.21 BBAminus -139.77, 176.54 -136.01, 97.7 -86.48, -26.06 306.23, 126.32 100.15, -136.94 in-in in 8.78 Saltbr-in 2.786 HRD-in -78.13, -54.62 75.98, 5.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, 43.71 APE9-dihe-na -114.3, 132.58 APE8-dihe-in -127.74, 146.12 APE8-rot-out 68.03 APE67-dihe-in -66.61, -22.51 -99.38, 17.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.82 APE9-dist-out 11.271 None None None XRAY 2.65 0.2 0.228 A 405 333 28 0 0 17 [[22, 335]] 1.0 4f7n Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 5HVYA P49336 1 359 464.0 66X:60501 Type2 Inactive DFGout 15.175 9.312 BBAminus -147.75, 175.04 -130.64, 103.81 -80.2, 9.83 305.77, 118.03 84.07, 29.62 out-out out 11.267 Saltbr-out 6.112 HRD-in -85.57, -56.75 82.18, -2.99 out-out-out SNCooo out-out ActLoopNT-out 12.861 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -86.7, 132.16 APE9-dihe-na -171.76, 167.74 APE8-dihe-in -116.95, 139.23 APE8-rot-out 61.83 APE67-dihe-in -58.0, -28.58 -98.28, 0.53 APE12-dist-out 14.371 APE11-dist-in 9.032 APE10-dist-out 8.299 APE9-dist-out 10.379 None None None XRAY 2.39 0.181 0.22 A 406 333 26 0 0 12 [[22, 335]] 1.0 5hvy Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 6TPAA P49336 1 359 464.0 NZ8:60501,NZ5:60505,NZ5:60506,NZ5:60507 Type2,Allosteric,Allosteric,Allosteric Inactive DFGout 13.832 11.818 BBAminus -130.48, -178.36 -144.36, 91.14 -84.2, -4.16 322.15, 13.04 -124.91, 44.75 out-out out 10.182 Saltbr-out 4.955 HRD-in -82.95, -50.83 78.95, 15.78 out-out-out SNCooo out-out ActLoopNT-out 11.908 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.19 APE8-rot-out 87.86 APE67-dihe-in -63.33, -23.46 -113.41, 27.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.228 0.264 A 405 334 25 0 0 16 [[22, 335]] 1.0 6tpa Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 4F6SA P49336 1 359 464.0 0SQ:60501 Type3 Inactive DFGout 13.878 7.557 BBAminus -143.37, 174.31 -133.59, 95.54 -89.33, -12.55 298.0, 127.79 85.97, -154.1 in-in in 8.67 Saltbr-in 2.813 HRD-in -74.89, -55.83 78.59, -0.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.84 APE8-dihe-in -132.11, 155.15 APE8-rot-out 82.42 APE67-dihe-in -62.47, -25.65 -106.71, 17.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.87 None None None XRAY 2.6 0.205 0.26 A 405 327 32 0 0 17 [[22, 335]] 1.0 4f6s Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 4F7JA P49336 1 359 464.0 0SU:60501 Type3 Inactive DFGout 14.423 8.595 BBAminus -131.55, -173.38 -148.17, 95.28 -72.43, -38.8 311.88, 131.51 104.34, -133.92 in-in in 8.724 Saltbr-in 2.664 HRD-in -75.51, -51.42 85.3, -13.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.87 APE8-dihe-in -70.46, 100.26 APE8-rot-in 296.32 APE67-dihe-in -60.95, -26.84 -87.97, 10.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.055 None None None XRAY 2.6 0.229 0.276 A 405 326 33 0 0 18 [[22, 335]] 1.0 4f7j Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CDK8_HUMAN 4F70A P49336 1 359 464.0 0ST:60501 Type3 Inactive None 18.647 14.421 None -123.12, -177.92 -154.05, 113.27 -90.85, 999.0 75.63, 12.09 999.0, 999.0 in-in in 8.993 Saltbr-in 3.008 HRD-in -82.85, -48.58 74.91, -2.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 73.37 APE8-dihe-in -133.51, 141.85 APE8-rot-out 58.33 APE67-dihe-in -73.19, -29.13 -108.0, 28.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.562 None None None XRAY 3.0 0.204 0.239 A 405 326 33 0 0 20 [[22, 335]] 1.0 4f70 Homo sapiens CMGC_CDK8_HUMAN CMGC 5.9e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8

CMGC_CDK8 (Cyclin-dependent kinase 8)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name