JAK3 (Tyrosine-protein kinase JAK3)

JAK3 has two kinase domains in its sequence, labeled here as JAK3-1 and JAK3-2. Structures with both domains are given in the last table and labeled as JAK3-12.
Domain_1: JAK3-1
Total number of chains: 0

JAK3 (Tyrosine-protein kinase JAK3)

Domain_2: JAK3-2
Group: TYR
Example Uniprot: JAK3_HUMAN
Domain boundary: 822 - 1111

Total number of chains in: 71
Spatial Dihedral Chains Representative
DFGin BLAminus 69 AF-P52333-K2A
DFGin ABAminus 2 7C3NA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens JAK3_HUMAN 7C3NA 1.98 Inactive DFGin ABAminus in-in in-in FHX Type1 814 - 1102 None X980,X981 0
Homo sapiens JAK3_HUMAN 3LXKA 2.0 Inactive DFGin ABAminus in-in in-in MI1 Type1 815 - 1098 C1048S None 0
Homo sapiens JAK3_HUMAN AF-P52333-K2A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 814 - 1105 None None 0
Homo sapiens JAK3_HUMAN 6HZVA 2.46 None DFGin BLAminus in-in in-none GYW Type1 815 - 1098 None X980,X981 0
Homo sapiens JAK3_HUMAN 6HZVB 2.46 None DFGin BLAminus in-in in-none GYW Type1 815 - 1099 None X980,X981 0
Homo sapiens JAK3_HUMAN 6HZVC 2.46 Active DFGin BLAminus in-in in-in GYW Type1 815 - 1098 None X980,X981 0
Homo sapiens JAK3_HUMAN 6HZVD 2.46 Active DFGin BLAminus in-in in-in GYW Type1 815 - 1098 None X980,X981 0
Homo sapiens JAK3_HUMAN 5W86A 2.61 Inactive DFGin BLAminus in-in in-out 9YV Type1 814 - 1098 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 5W86B 2.61 Active DFGin BLAminus in-in in-in 9YV Type1 816 - 1098 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 5W86C 2.61 None DFGin BLAminus in-in in-none 9YV Type1 814 - 1099 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 5W86D 2.61 Inactive DFGin BLAminus in-in in-out 9YV Type1 814 - 1099 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 6AAKA 2.67 Active DFGin BLAminus in-in in-in 9T6 Type1 815 - 1098 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 6AAKB 2.67 Active DFGin BLAminus in-in in-in 9T6 Type1 815 - 1100 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 6AAKC 2.67 Active DFGin BLAminus in-in in-in 9T6 Type1 814 - 1099 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 6AAKD 2.67 Active DFGin BLAminus in-in in-in 9T6 Type1 814 - 1098 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 3ZC6A 2.42 Active DFGin BLAminus in-in in-in VFC Type1 814 - 1100 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 3ZC6B 2.42 Active DFGin BLAminus in-in in-in VFC Type1 813 - 1100 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 3ZC6C 2.42 Inactive DFGin BLAminus in-in in-out VFC Type1 814 - 1100 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 3ZC6D 2.42 None DFGin BLAminus in-in in-none VFC Type1 814 - 1100 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 3ZEPA 2.35 Active DFGin BLAminus in-in in-in 1NX Type1 814 - 1098 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 3ZEPB 2.35 Active DFGin BLAminus in-in in-in 1NX Type1 814 - 1100 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 3ZEPC 2.35 Active DFGin BLAminus in-in in-in 1NX Type1 814 - 1100 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 3ZEPD 2.35 Active DFGin BLAminus in-in in-in 1NX Type1 814 - 1099 C1040S,C1048S X980,X981 0
Homo sapiens JAK3_HUMAN 7UYVA 2.15 Active DFGin BLAminus in-in in-in OV5 Type1 814 - 1100 None X980,X981 0
Homo sapiens JAK3_HUMAN 7UYVB 2.15 Active DFGin BLAminus in-in in-in OV5 Type1 814 - 1100 None X980,X981 0
Homo sapiens JAK3_HUMAN 7UYVC 2.15 Inactive DFGin BLAminus in-in in-out OV5 Type1 812 - 1100 None X980,X981 0
Homo sapiens JAK3_HUMAN 7UYVD 2.15 Active DFGin BLAminus in-in in-in OV5 Type1 814 - 1100 None X980,X981 0
Homo sapiens JAK3_HUMAN 4RIOA 2.69 Active DFGin BLAminus in-in in-in 3QX Type1 815 - 1099 C811S,C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 5VO6A 2.65 None DFGin BLAminus in-in in-none 9J4 Type1 815 - 1099 C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 5WFJA 2.48 Active DFGin BLAminus in-in in-in 9Z4 Type1 817 - 1099 C811S,C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 6NY4A 2.33 Active DFGin BLAminus in-in in-in Z3A Type1 815 - 1099 C811S,C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 4HVDA 1.85 Active DFGin BLAminus in-in in-in 933 Type1 815 - 1101 C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 4HVGA 2.75 Active DFGin BLAminus in-in in-in 19Q Type1 814 - 1103 C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 4HVHA 2.3 Active DFGin BLAminus in-in in-in 19R Type1 814 - 1102 C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 4HVIA 2.4 Active DFGin BLAminus in-in in-in 19S Type1 815 - 1101 C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 4I6QA 1.85 Active DFGin BLAminus in-in in-in 1DT Type1 815 - 1102 C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 4QT1A 2.4 Active DFGin BLAminus in-in in-in 3C9 Type1 814 - 1102 C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 3PJCA 2.2 Active DFGin BLAminus in-in in-in PJC Type1 815 - 1104 None None 0
Homo sapiens JAK3_HUMAN 5TOZA 1.98 Active DFGin BLAminus in-in in-in 7H4 Type1 815 - 1100 None None 0
Homo sapiens JAK3_HUMAN 5TTSA 2.34 Active DFGin BLAminus in-in in-in 7KU Type1 814 - 1100 C1048S None 0
Homo sapiens JAK3_HUMAN 5TTUA 1.72 Active DFGin BLAminus in-in in-in 7KV Type1 815 - 1099 C1048S None 0
Homo sapiens JAK3_HUMAN 5TTVA 1.93 Active DFGin BLAminus in-in in-in 7KX Type1 814 - 1100 C1048S None 0
Homo sapiens JAK3_HUMAN 6DA4A 2.9 Active DFGin BLAminus in-in in-in G4V Type1 815 - 1099 C1048S None 0
Homo sapiens JAK3_HUMAN 6DB3A 1.97 Active DFGin BLAminus in-in in-in G54 Type1 814 - 1100 C1048S None 0
Homo sapiens JAK3_HUMAN 6DB4A 1.662 Active DFGin BLAminus in-in in-in G4Y Type1 814 - 1100 C1048S None 0
Homo sapiens JAK3_HUMAN 6DUDA 1.66 Active DFGin BLAminus in-in in-in HB4 Type1 814 - 1100 C1048S None 0
Homo sapiens JAK3_HUMAN 7Q6HAAA 1.749 Active DFGin BLAminus in-in in-in 934 Type1 814 - 1100 None None 0
Homo sapiens JAK3_HUMAN 3LXLA 1.74 Active DFGin BLAminus in-in in-in IZA Type1 814 - 1098 C1048S None 0
Homo sapiens JAK3_HUMAN 4V0GB 3.0 None DFGin BLAminus in-in in-none G9B Type1 816 - 1098 None X980,X981 0
Homo sapiens JAK3_HUMAN 4V0GA 3.0 None DFGin BLAminus in-in in-none G9B Type1 817 - 1098 None X980,X981 0
Homo sapiens JAK3_HUMAN 1YVJA 2.55 Inactive DFGin BLAminus in-in in-out 4ST Type1 814 - 1103 None X980,X981 0
Homo sapiens JAK3_HUMAN 4Z16A 2.9 None DFGin BLAminus in-in in-none 4LH Type1 814 - 1103 None X980,X981 0
Homo sapiens JAK3_HUMAN 4Z16B 2.9 Active DFGin BLAminus in-in in-in 4LH Type1 814 - 1103 None X980,X981 0
Homo sapiens JAK3_HUMAN 4Z16C 2.9 None DFGin BLAminus in-in in-none 4LH Type1 814 - 1103 None X980,X981 0
Homo sapiens JAK3_HUMAN 4Z16D 2.9 None DFGin BLAminus in-in in-none 4LH Type1 814 - 1103 None X980,X981 0
Homo sapiens JAK3_HUMAN 4QPSA 1.8 None DFGin BLAminus in-in in-none 37Q Type1 814 - 1100 D949A,C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 4QPSC 1.8 Inactive DFGin BLAminus in-in in-out 37Q Type1 814 - 1102 D949A,C1040S,C1048S None 0
Homo sapiens JAK3_HUMAN 5LWMA 1.55 Inactive DFGin BLAminus in-in in-out 79T Type1 814 - 1103 None None 0
Homo sapiens JAK3_HUMAN 6GL9A 1.7 Active DFGin BLAminus in-in in-in F3W Type1 812 - 1103 None None 0
Homo sapiens JAK3_HUMAN 6GL9B 1.7 Active DFGin BLAminus in-in in-in F3W Type1 813 - 1103 None None 0
Homo sapiens JAK3_HUMAN 6GLAA 1.92 Active DFGin BLAminus in-in in-in F4B Type1 813 - 1103 None None 0
Homo sapiens JAK3_HUMAN 6GLAB 1.92 Active DFGin BLAminus in-in in-in F4B Type1 813 - 1103 None None 0
Homo sapiens JAK3_HUMAN 6GLBA 2.0 Active DFGin BLAminus in-in in-in F48 Type1 813 - 1103 None None 0
Homo sapiens JAK3_HUMAN 6GLBB 2.0 Active DFGin BLAminus in-in in-in F48 Type1 813 - 1103 None None 0
Homo sapiens JAK3_HUMAN 7APFA 1.95 Inactive DFGin BLAminus in-in in-out RQZ Type1 814 - 1103 None None 0
Homo sapiens JAK3_HUMAN 7APFB 1.95 Inactive DFGin BLAminus in-in in-out RQZ Type1 814 - 1103 None None 0
Homo sapiens JAK3_HUMAN 7APGA 2.4 Inactive DFGin BLAminus in-in in-out RQT Type1 813 - 1103 None None 0
Homo sapiens JAK3_HUMAN 7APGB 2.4 Inactive DFGin BLAminus in-in in-out RQT Type1 814 - 1103 None None 0
Homo sapiens JAK3_HUMAN 7APGC 2.4 Inactive DFGin BLAminus in-in in-out RQT Type1 812 - 1103 None None 0
Homo sapiens JAK3_HUMAN 7APGD 2.4 Inactive DFGin BLAminus in-in in-out RQT Type1 815 - 1103 None None 0
Homo sapiens JAK3_HUMAN 5LWNA 1.6 Inactive DFGin BLAminus in-in in-out 79R 79S Type1 Type1 814 - 1103 None None 0

JAK3 (Tyrosine-protein kinase JAK3)

Domain_12: JAK3-12
Total number of chains in: 0. Analysis of 2nd kinase domain given in table below.