MLKL (Mixed lineage kinase domain-like protein)

Pseudokinase
Group: OTHER
Uniprot: MLKL_HUMAN
Domain boundary: 201 - 468


Total number of chains: 15
Spatial Dihedral Chains Representative
DFGin BLAminus 1 6O5ZA
DFGin BLAplus 3 7JXUA
DFGin BLBminus 8 4MWIA
DFGout None 1 6O5ZB
None None 2 5KNJB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
6O5ZA 2.285 Inactive DFGin BLAminus in-in out-out No_ligand No_ligand 191 - 470 None None 9
7JXUA 2.44 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 191 - 471 None None 0
7JXUB 2.44 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 191 - 471 None None 0
7MONA 2.23 Inactive DFGin BLAplus out-out out-out ZL1 Type1 191 - 469 None None 8
4MWIA 1.7 Inactive DFGin BLBminus in-in out-out PXN Allosteric 193 - 470 None None 12
6BWKA 2.79 Inactive DFGin BLBminus in-none none-out No_ligand No_ligand 192 - 470 T357E,S358E None 16
7JW7A 2.63 Inactive DFGin BLBminus in-in none-out No_ligand No_ligand 191 - 470 None None 19
8SLZA 2.3 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 191 - 469 None X357,X358 14
4M67A 1.9 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 192 - 469 None None 14
6LK6A 2.41 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 192 - 470 T357A,S358A None 14
6LK5A 2.5 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 192 - 470 T357E,S358D None 14
5KO1A 2.16 Inactive DFGin BLBminus in-in out-out 6UY Type1 192 - 470 E366A,K367A None 14
6O5ZB 2.285 Inactive DFGout None in-out none-out LN4 Type2 190 - 467 None None 12
5KNJA 2.88 Inactive None None in-in none-out 6UX Type1 193 - 468 E366A,K367A None 18
5KNJB 2.88 Inactive None None in-in none-out 6UX Type1 192 - 469 E366A,K367A None 19

MLKL (Mixed lineage kinase domain-like protein)

Pseudokinase
Group: OTHER
Total number of chains: 23
Spatial Dihedral Chains Representative
DFGin BLAminus 1 6O5ZA
DFGin BLAplus 5 7JXUA
DFGin BLBminus 13 6VC0A
DFGout None 1 6O5ZB
None None 3 4M69B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Equus caballus F6S337_HORSE 6VC0A 2.746 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 258 - 536 None None 7
Equus caballus F6S337_HORSE 6VC0B 2.746 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 258 - 537 None None 11
Equus caballus F6S337_HORSE 6VC0C 2.746 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 258 - 541 None None 8
Homo sapiens MLKL_HUMAN 6O5ZA 2.285 Inactive DFGin BLAminus in-in out-out No_ligand No_ligand 191 - 470 None None 9
Homo sapiens MLKL_HUMAN 7JXUA 2.44 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 191 - 471 None None 0
Homo sapiens MLKL_HUMAN 7JXUB 2.44 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 191 - 471 None None 0
Homo sapiens MLKL_HUMAN 7MONA 2.23 Inactive DFGin BLAplus out-out out-out ZL1 Type1 191 - 469 None None 8
Homo sapiens MLKL_HUMAN 4MWIA 1.7 Inactive DFGin BLBminus in-in out-out PXN Allosteric 193 - 470 None None 12
Homo sapiens MLKL_HUMAN 6BWKA 2.79 Inactive DFGin BLBminus in-none none-out No_ligand No_ligand 192 - 470 T357E,S358E None 16
Homo sapiens MLKL_HUMAN 7JW7A 2.63 Inactive DFGin BLBminus in-in none-out No_ligand No_ligand 191 - 470 None None 19
Homo sapiens MLKL_HUMAN 8SLZA 2.3 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 191 - 469 None X357,X358 14
Homo sapiens MLKL_HUMAN 4M67A 1.9 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 192 - 469 None None 14
Homo sapiens MLKL_HUMAN 6LK6A 2.41 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 192 - 470 T357A,S358A None 14
Homo sapiens MLKL_HUMAN 6LK5A 2.5 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 192 - 470 T357E,S358D None 14
Homo sapiens MLKL_HUMAN 5KO1A 2.16 Inactive DFGin BLBminus in-in out-out 6UY Type1 192 - 470 E366A,K367A None 14
Homo sapiens MLKL_HUMAN 6O5ZB 2.285 Inactive DFGout None in-out none-out LN4 Type2 190 - 467 None None 12
Homo sapiens MLKL_HUMAN 5KNJA 2.88 Inactive None None in-in none-out 6UX Type1 193 - 468 E366A,K367A None 18
Homo sapiens MLKL_HUMAN 5KNJB 2.88 Inactive None None in-in none-out 6UX Type1 192 - 469 E366A,K367A None 19
Mus musculus MLKL_MOUSE 4M68A 1.696 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 182 - 466 None None 9
Mus musculus MLKL_MOUSE 4BTFA 2.604 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 2 - 463 None None 8
Mus musculus MLKL_MOUSE 4M69B 2.497 Inactive None None out-out out-out No_ligand No_ligand 182 - 466 None None 13
Rattus norvegicus D3ZKP6_RAT 6VBZA 2.192 Inactive DFGin BLBminus in-in none-out No_ligand No_ligand 183 - 454 None None 16
Rattus norvegicus D3ZKP6_RAT 6VBZB 2.192 Inactive DFGin BLBminus in-in none-out No_ligand No_ligand 182 - 454 None None 17

MLKL (Mixed lineage kinase domain-like protein)

Pseudokinase
Group: OTHER
Total number of chains: 8
Spatial Dihedral Chains Representative
DFGin BLAplus 2 4BTFA
DFGin BLBminus 5 6VC0A
None None 1 4M69B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Equus caballus F6S337_HORSE 6VC0A 2.746 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 258 - 536 None None 7
Equus caballus F6S337_HORSE 6VC0B 2.746 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 258 - 537 None None 11
Equus caballus F6S337_HORSE 6VC0C 2.746 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 258 - 541 None None 8
Mus musculus MLKL_MOUSE 4M68A 1.696 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 182 - 466 None None 9
Mus musculus MLKL_MOUSE 4BTFA 2.604 Inactive DFGin BLAplus out-out out-out No_ligand No_ligand 2 - 463 None None 8
Mus musculus MLKL_MOUSE 4M69B 2.497 Inactive None None out-out out-out No_ligand No_ligand 182 - 466 None None 13
Rattus norvegicus D3ZKP6_RAT 6VBZA 2.192 Inactive DFGin BLBminus in-in none-out No_ligand No_ligand 183 - 454 None None 16
Rattus norvegicus D3ZKP6_RAT 6VBZB 2.192 Inactive DFGin BLBminus in-in none-out No_ligand No_ligand 182 - 454 None None 17