EIF2AK4 (eIF-2-alpha kinase GCN2)

EIF2AK4 has two kinase domains in its sequence, labeled here as EIF2AK4-1 and EIF2AK4-2. Structures with both domains are given in the last table and labeled as EIF2AK4-12.
Domain_1: EIF2AK4-1
Total number of chains: 0

EIF2AK4 (eIF-2-alpha kinase GCN2)

Domain_2: EIF2AK4-2
Group: OTHER
Example Uniprot: E2AK4_HUMAN
Domain boundary: 590 - 1001

Total number of chains in: 17
Spatial Dihedral Chains Representative
DFGin BLAminus 3 AF-Q9P2K8-K2A
DFGin None 4 7QQ6A
DFGinter BABtrans 1 7QWKH
DFGinter None 1 7QWKF
DFGout None 8 7QWKA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment

Database table as tsv
Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens E2AK4_HUMAN AF-Q9P2K8-K2A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 582 - 1009 None None 0
Homo sapiens E2AK4_HUMAN 6N3NA 3.01 None DFGin BLAminus out-out out-none KA4 Type1 584 - 1003 K807A,D848N,T899E,T904E None 0
Homo sapiens E2AK4_HUMAN 6N3OA 2.4 None DFGin BLAminus out-out out-none KA7 Type1.5_Back 584 - 1004 K807A,D848N,T899E,T904E None 0
Homo sapiens E2AK4_HUMAN 7QQ6A 2.8 Inactive DFGin None out-out none-out 38O Type1 584 - 1004 D848N None 0
Homo sapiens E2AK4_HUMAN 7QQ6B 2.8 Inactive DFGin None out-out none-out 38O Type1 584 - 1006 D848N None 0
Homo sapiens E2AK4_HUMAN 7QQ6C 2.8 Inactive DFGin None out-out out-out 38O Type1 584 - 1006 D848N None 0
Homo sapiens E2AK4_HUMAN 7QQ6D 2.8 Inactive DFGin None out-out out-none 38O Type1 584 - 1006 D848N None 0
Homo sapiens E2AK4_HUMAN 7QWKH 2.3 Inactive DFGinter BABtrans out-out out-out G41 Type1 584 - 1006 D848N None 0
Homo sapiens E2AK4_HUMAN 7QWKF 2.3 Inactive DFGinter None out-out out-out G41 Type1 584 - 1005 D848N None 0
Homo sapiens E2AK4_HUMAN 7QWKA 2.3 Inactive DFGout None out-none none-out G41 Type1 583 - 998 D848N None 0
Homo sapiens E2AK4_HUMAN 7QWKB 2.3 Inactive DFGout None out-out out-out G41 Type1 583 - 998 D848N None 0
Homo sapiens E2AK4_HUMAN 7QWKC 2.3 Inactive DFGout None out-out out-none G41 Type1 583 - 1004 D848N None 0
Homo sapiens E2AK4_HUMAN 7QWKD 2.3 Inactive DFGout None out-out out-out G41 Type1 583 - 1003 D848N None 0
Homo sapiens E2AK4_HUMAN 7QWKE 2.3 Inactive DFGout None out-none none-none G41 Type1 584 - 1004 D848N None 0
Homo sapiens E2AK4_HUMAN 7QWKG 2.3 Inactive DFGout None out-out out-none G41 Type1 584 - 1007 D848N None 0
Homo sapiens E2AK4_HUMAN 6N3LA 2.61 Inactive DFGout None in-in none-none KAV Type2 584 - 1002 K807A,D848N,T899A,T904A None 0
Homo sapiens E2AK4_HUMAN 6N3LB 2.61 Inactive DFGout None in-in none-none KAV Type2 584 - 1002 K807A,D848N,T899A,T904A None 0

EIF2AK4 (eIF-2-alpha kinase GCN2)

Domain_12: EIF2AK4-12
Total number of chains in: 0. Analysis of 2nd kinase domain given in table below.