7QWK

EIF2AK4 (eIF-2-alpha kinase GCN2)
Group: OTHER
Uniprot: E2AK4_HUMAN
Organism: Homo sapiens
Domain boundary: 590 - 1001
Resolu: 2.3

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGout None out-none none-out G41 Type1 583 - 998 0
B Inactive DFGout None out-out out-out G41 Type1 583 - 998 0
C Inactive DFGout None out-out out-none G41 Type1 583 - 1004 0
D Inactive DFGout None out-out out-out G41 Type1 583 - 1003 0
E Inactive DFGout None out-none none-none G41 Type1 584 - 1004 0
F Inactive DFGinter None out-out out-out G41 Type1 584 - 1005 0
G Inactive DFGout None out-out out-none G41 Type1 584 - 1007 0
H Inactive DFGinter BABtrans out-out out-out G41 Type1 584 - 1006 0
Representative sequence - Chain H
586 596 606 616
setqrqfSRY FIEFEELQLL GKGAFGAVIK VQNKLDGCCY
626 636 646 656
AVKRIPINPA SRQFRRIKGE VTLLSRLHHE NIVRYYNAWI
792 802 812 822
ERHerpsvtt eaVHYLYIQM EYCEKSTLRD TIDQGLYRDT
832 842 852 862
VRLWRLFREI LDGLAYIHEK GMIHRNLKPV NIFLDSDDHV
872 882 892 902
KIGDFGLATD Hlafsadskq ddqtgdliks DPSGHLTGMV
912 922 932 942
GTALYVSPEV qgstKSAYNQ KVDLFSLGII FFEMSYHPMV
952 962 972 982
TASERIFVLN QLRDptsPKF PEDFDdgeHA KQKSVISWLL
992 1002 1012
NHDPAKRPTA TELLKSELLP PPQMeeselh evlhhtlt
Lower-case residues are disordered in structure.
Mutations: D848N
Phosphorylation: None