Ligand: DB8 (Bosutinib, Bosulif)

Total number of chains: 26
Active chains: 1
Total number of genes: 12
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 17 65.4% 5VCYA
DFGin None 2 7.7% 5AJQA
DFGinter None 2 7.7% 9D5FA
DFGout None 2 7.7% 3UE4A
DFGin BLBminus 1 3.8% 5I9XA
DFGin BLBplus 1 3.8% 6OP9A
DFGinter BABtrans 1 3.8% 4MXXB
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK CAMK2A KCC2A_HUMAN 3SOAA Q9UQM7 7 474 478.0 DB8:60445 Type1 Inactive DFGinter 10.807 10.237 None -98.86, 109.77 -79.7, 114.69 -137.02, 147.48 315.53, 123.27 104.35, -23.23 in-na in 8.799 Saltbr-na 999.0 HRD-in -73.81, -41.57 68.14, -19.19 na-in-in SNCaii in-in ActLoopNT-in 3.181 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.13, 161.55 APE9-dihe-na 103.67, -177.05 APE8-dihe-in -98.78, 133.3 APE8-rot-in 301.55 APE67-dihe-in -73.82, -31.03 -42.95, -42.2 APE12-dist-in 9.829 APE11-dist-in 10.848 APE10-dist-in 5.275 APE9-dist-in 3.989 K42M,D135N,T306V None None XRAY 3.55 0.279 0.327 A 444 436 2 0 0 0 [[13, 271]] 1.0 3soa CAMK_CAMK2A_HUMAN CAMK 2.8e-93 318.5 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK SIK3 SIK3_HUMAN 8R4QA Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.27 14.887 BLAminus -139.01, 171.07 65.51, 84.49 -98.95, 35.4 290.76, 86.17 -67.45, -37.73 in-out in 9.482 Saltbr-out 4.139 HRD-in -65.82, -56.46 69.69, -0.35 out-in-out SNCoio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.28, 159.93 APE9-dihe-na 142.02, 171.32 APE8-dihe-in -81.41, 117.57 APE8-rot-out 188.89 APE67-dihe-in -62.69, -24.82 -43.74, -50.05 APE12-dist-in 7.634 APE11-dist-in 11.009 APE10-dist-in 5.294 APE9-dist-in 3.232 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 A 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4QC Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.293 14.764 BLAminus -135.25, 170.61 66.71, 84.0 -99.07, 36.48 291.2, 85.91 -69.03, -37.82 in-out in 9.499 Saltbr-out 4.06 HRD-in -75.57, -57.14 68.81, -4.17 out-in-out SNCoio in-out ActLoopNT-in 2.89 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.57, 158.49 APE9-dihe-na 142.55, 170.52 APE8-dihe-in -81.5, 119.22 APE8-rot-out 55.54 APE67-dihe-in -62.66, -24.97 -44.86, -49.85 APE12-dist-in 7.616 APE11-dist-in 10.986 APE10-dist-in 5.263 APE9-dist-in 3.238 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 C 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4QE Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.31 14.801 BLAminus -139.98, 171.19 65.46, 83.84 -99.17, 35.86 291.35, 86.11 -68.1, -36.3 in-out in 9.532 Saltbr-out 4.096 HRD-in -73.14, -51.55 63.42, 1.74 out-in-out SNCoio in-out ActLoopNT-in 3.101 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.33, 159.33 APE9-dihe-na 142.87, 171.07 APE8-dihe-in -80.24, 117.39 APE8-rot-out 190.21 APE67-dihe-in -61.05, -42.7 -42.39, -51.02 APE12-dist-in 7.543 APE11-dist-in 10.939 APE10-dist-in 5.259 APE9-dist-in 3.332 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 E 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4QG Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.382 14.787 BLAminus -136.43, 170.69 66.72, 83.62 -98.78, 33.02 291.62, 86.44 -67.7, -37.12 in-out in 9.555 Saltbr-out 3.974 HRD-in -68.39, -50.34 62.72, 11.29 out-in-out SNCoio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.11, 159.76 APE9-dihe-na 140.64, 172.45 APE8-dihe-in -81.58, 117.44 APE8-rot-out 189.92 APE67-dihe-in -60.6, -25.5 -43.58, -51.63 APE12-dist-in 7.433 APE11-dist-in 10.791 APE10-dist-in 5.137 APE9-dist-in 3.243 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 G 328 320 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4QI Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.29 14.857 BLAminus -140.96, 171.42 64.9, 84.12 -97.96, 35.72 290.26, 86.39 -67.95, -38.18 in-out in 9.544 Saltbr-out 4.083 HRD-in -66.19, -52.55 62.88, 16.03 out-in-out SNCoio in-out ActLoopNT-in 2.935 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.02, 158.46 APE9-dihe-na 144.09, 168.25 APE8-dihe-in -80.55, 117.37 APE8-rot-out 188.41 APE67-dihe-in -62.44, -25.32 -44.55, -49.34 APE12-dist-in 7.633 APE11-dist-in 10.97 APE10-dist-in 5.248 APE9-dist-in 3.292 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 I 328 316 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4QK Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.303 14.862 BLAminus -130.99, 169.6 63.77, 94.11 -108.55, 39.14 294.05, 89.24 -69.02, -37.64 in-out in 9.921 Saltbr-out 5.202 HRD-in -62.64, -54.81 63.03, 15.84 out-in-out SNCoio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.45, 159.5 APE9-dihe-na 141.76, 170.37 APE8-dihe-in -80.52, 118.54 APE8-rot-out 187.31 APE67-dihe-in -62.28, -24.73 -43.25, -51.12 APE12-dist-in 7.521 APE11-dist-in 10.96 APE10-dist-in 5.223 APE9-dist-in 3.254 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 K 328 318 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
OTHER PKMYT1 PMYT1_HUMAN 5VCYA Q99640 77 362 499.0 DB8:60401 Type1 Inactive DFGin 5.969 14.359 BLAminus -127.91, -168.29 70.38, 72.35 -96.64, 23.14 300.41, 119.28 -68.58, -24.5 in-in in 8.714 Saltbr-in 2.719 HRD-in -69.32, -46.71 70.97, 0.9 in-in-out SNCiio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -97.27, 135.17 APE9-dihe-na -76.61, -179.9 APE8-dihe-in -57.88, 126.16 APE8-rot-na 189.14 APE67-dihe-in -62.75, -28.84 -62.08, -23.7 APE12-dist-in 8.015 APE11-dist-out 5.197 APE10-dist-out 9.02 APE9-dist-in 3.47 None None None XRAY 1.56 0.14 0.178 A 311 286 0 0 0 0 [[110, 359]] 1.0 5vcy OTHER_PKMYT1_HUMAN STE 9.9e-39 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER ULK3 ULK3_HUMAN 6FDYU Q6PHR2 9 274 472.0 DB8:301,DB8:302 Type1,Allosteric Inactive DFGin 6.874 15.807 BLAminus -121.89, 168.03 58.05, 74.57 -82.78, 25.82 281.46, 65.78 -64.66, -23.35 out-out out 11.318 Saltbr-out 6.975 HRD-in -73.35, -48.54 71.13, 8.1 out-in-in SNCoii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.42, 135.02 APE9-dihe-na 116.19, -156.99 APE8-dihe-in -126.23, 135.32 APE8-rot-in 297.86 APE67-dihe-in -77.76, -4.76 -49.56, -42.9 APE12-dist-in 9.776 APE11-dist-in 10.466 APE10-dist-in 5.312 APE9-dist-in 3.261 None None None XRAY 1.7 0.207 0.239 U 276 262 4 0 0 0 [[14, 270]] 1.0 6fdy OTHER_ULK3_HUMAN ULK 2.9e-126 426.0 1 256 256 156 157 158 160 162 44 62 66 134 136 135 137 195 183 178 177 176 175 174 173 172 92 Serine/threonine-protein kinase ULK3
OTHER WEE1 WEE1_HUMAN 5VC3A P30291 293 570 646.0 DB8:601 Type1 Inactive DFGin 5.869 13.847 BLAminus -114.82, -178.11 54.56, 79.37 -92.53, 24.23 299.17, 19.73 -68.72, -22.16 out-out out 10.357 Saltbr-out 5.286 HRD-in -86.82, -42.16 64.96, 14.12 out-in-out SNCoio in-out ActLoopNT-in 2.991 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -59.88, 134.71 APE9-dihe-na -71.82, -169.68 APE8-dihe-in -52.32, 129.97 APE8-rot-na 194.6 APE67-dihe-in -75.75, -17.17 -62.12, -24.88 APE12-dist-in 8.32 APE11-dist-out 5.181 APE10-dist-out 9.248 APE9-dist-in 3.434 None None None XRAY 1.97 0.212 0.254 A 289 260 18 0 0 0 [[299, 569]] 1.0 5vc3 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
STE STK10 STK10_HUMAN 5AJQA O94804 24 312 968.0 DB8:800 Type1 Inactive DFGin 6.259 15.744 None -120.59, 174.2 81.32, -56.36 57.24, 29.42 287.8, 79.18 102.53, -17.28 out-out out 10.748 Saltbr-out 10.947 HRD-in -68.33, -48.71 84.04, -21.17 out-out-out SNCooo out-out ActLoopNT-out 12.573 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -85.91, 130.23 APE9-dihe-na 91.1, 7.46 APE8-dihe-in -59.1, 130.74 APE8-rot-in 288.9 APE67-dihe-out -66.14, -20.66 -86.49, 69.24 APE12-dist-none 999.0 APE11-dist-out 18.692 APE10-dist-out 14.146 APE9-dist-out 10.682 None None None XRAY 2.2 0.219 0.257 A 295 280 9 0 0 6 [[36, 294]] 1.0 5ajq STE_STK10_HUMAN STE 1.9e-94 321.7 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5AJQB O94804 25 312 968.0 DB8:800 Type1 Inactive DFGin 6.286 15.939 None -120.49, 173.38 83.25, -57.95 53.22, 23.51 288.78, 77.4 -62.81, -49.77 out-none out 10.89 Saltbr-none 999.0 HRD-in -69.73, -48.6 82.63, -20.29 none-out-none SNCnon out-none ActLoopNT-out 6.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 83.37 APE8-rot-in 290.95 APE67-dihe-in -67.97, -24.14 -101.21, 28.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.219 0.257 B 295 267 21 0 0 13 [[36, 294]] 1.0 5ajq STE_STK10_HUMAN STE 1.9e-94 321.7 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK24 STK24_HUMAN 4QMNA Q9Y6E0 27 310 443.0 DB8:60401 Type1 Active DFGin 6.754 15.582 BLAminus -132.67, 174.27 64.71, 80.09 -95.84, 30.95 285.18, 68.8 -57.26, -28.92 in-in in 9.748 Saltbr-in 3.524 HRD-in -76.5, -47.9 71.96, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.707 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 157.72 APE9-dihe-na 133.63, -173.45 APE8-dihe-in -111.31, 120.57 APE8-rot-in 310.4 APE67-dihe-in -59.08, -29.88 -38.92, -51.65 APE12-dist-in 8.326 APE11-dist-in 10.884 APE10-dist-in 5.068 APE9-dist-in 3.36 None TPO190 TPO190 XRAY 2.091 0.179 0.227 A 310 284 0 0 0 0 [[36, 286]] 1.0 4qmn STE_STK24_HUMAN STE 3.9e-100 340.4 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TKL ILK ILK_HUMAN 9D5FA Q13418 182 452 452.0 DB8:501 Type1 Pseudo DFGinter 8.366 7.592 None -82.6, 123.95 -74.1, -11.79 -66.74, -13.57 999.0, 999.0 -72.54, 5.75 out-out out 14.123 Saltbr-out 15.4 HRD-out -123.23, 159.13 -69.32, -46.01 out-out-out SNCooo out-out ActLoopNT-out 5.554 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -109.48, 117.62 APE9-dihe-na -102.03, -10.5 APE8-dihe-in -134.11, 56.74 APE8-rot-none 999.0 APE67-dihe-in -63.21, -21.45 -62.91, -18.33 APE12-dist-out 15.638 APE11-dist-out 14.874 APE10-dist-out 14.406 APE9-dist-out 8.782 C346S,C422S None None XRAY 1.5 0.191 0.208 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5f TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TYR ABL1 ABL1_HUMAN 3UE4A P00519 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.471 10.087 None -73.57, 139.68 -129.47, 18.74 -70.04, -27.22 71.97, 85.11 -97.86, 45.9 in-out in 8.122 Saltbr-out 4.005 HRD-out -105.15, 128.48 -83.8, -2.91 out-out-in SNCooi out-in ActLoopNT-out 5.294 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.88, 137.39 APE9-dihe-in -119.63, 157.7 APE8-dihe-in -69.93, 97.57 APE8-rot-na 25.4 APE67-dihe-in -65.99, -15.91 -45.97, -49.68 APE12-dist-na 19.211 APE11-dist-na 14.469 APE10-dist-na 17.122 APE9-dist-in 6.836 None None None XRAY 2.424 0.192 0.249 A 287 270 0 0 0 0 [[242, 495]] 1.0 3ue4 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3UE4B P00519 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.224 10.48 None -68.43, 143.68 -139.88, 24.33 -73.48, -36.67 65.16, 97.6 -93.69, 7.14 in-out in 8.491 Saltbr-out 3.771 HRD-in -88.28, -56.6 76.68, -0.41 out-out-in SNCooi out-in ActLoopNT-out 5.441 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.79, 122.21 APE9-dihe-in -108.43, 151.01 APE8-dihe-in -71.16, 105.45 APE8-rot-na 24.97 APE67-dihe-in -72.18, -12.67 -59.58, -44.17 APE12-dist-na 19.453 APE11-dist-na 14.748 APE10-dist-na 17.212 APE9-dist-in 6.892 None None None XRAY 2.424 0.192 0.249 B 287 268 2 0 0 0 [[242, 495]] 1.0 3ue4 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR EPHA2 EPHA2_HUMAN 5I9XA P29317 604 896 976.0 DB8:1001 Type1 Inactive DFGin 6.007 14.831 BLBminus -129.07, 177.72 76.64, 79.94 -112.75, 156.99 297.29, 98.79 146.97, -174.61 in-in in 8.09 Saltbr-in 3.299 HRD-in -74.57, -46.21 76.15, -16.23 in-out-in SNCioi out-in ActLoopNT-out 10.42 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.78, 113.1 APE9-dihe-in -147.01, 138.26 APE8-dihe-in -78.55, 92.56 APE8-rot-na 31.7 APE67-dihe-in -77.79, -2.98 -59.26, -48.48 APE12-dist-na 999.0 APE11-dist-na 14.091 APE10-dist-na 12.379 APE9-dist-in 6.799 None None None XRAY 1.427 0.166 0.182 A 306 284 9 0 0 4 [[613, 873]] 1.0 5i9x TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR ERBB3 ERBB3_HUMAN 6OP9A P21860 699 979 1342.0 DB8:61101 Type1 Pseudo DFGin 5.807 13.202 BLBplus -112.2, 168.23 74.7, 17.55 -72.83, 138.03 47.72, 93.08 81.75, -11.37 out-na out 15.256 Saltbr-na 999.0 HRD-in -65.5, -60.79 78.74, 0.36 na-out-out SNCaoo out-out ActLoopNT-out 6.69 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -72.9, -25.26 APE9-dihe-in -116.6, 159.4 APE8-dihe-in -83.21, 75.09 APE8-rot-na 31.73 APE67-dihe-in -70.29, -6.2 -48.51, -45.47 APE12-dist-na 999.0 APE11-dist-na 18.44 APE10-dist-na 14.221 APE9-dist-in 7.834 None None None XRAY 2.501 0.173 0.23 A 328 276 5 0 0 5 [[709, 967]] 1.0 6op9 TYR_ERBB3_HUMAN TYR 6.2e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR SRC SRC_HUMAN 4MXYA P12931 260 536 536.0 DB8:60601 Type1 Inactive DFGin 6.978 15.469 BLAminus -142.79, 170.65 62.95, 55.86 -70.4, 28.65 287.69, 79.24 -58.93, -6.93 in-out in 8.282 Saltbr-out 4.065 HRD-in -87.01, -42.61 78.79, -16.55 out-in-none SNCoin in-none ActLoopNT-in 3.007 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.72 APE8-dihe-in -52.37, 106.54 APE8-rot-na 27.67 APE67-dihe-in -73.74, -30.15 -77.33, -12.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.825 M317L,T341M None None XRAY 2.582 0.211 0.266 A 286 266 11 0 0 11 [[270, 521]] 1.0 4mxy TYR_SRC_HUMAN TYR 5.7e-94 320.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXYB P12931 261 536 536.0 DB8:60601 Type1 Inactive DFGin 7.454 15.832 BLAminus -129.72, -177.95 52.13, 75.68 -95.7, 22.45 293.45, 79.71 -64.73, -0.78 in-out in 8.476 Saltbr-out 4.823 HRD-in -98.19, -46.95 89.14, -36.87 out-in-none SNCoin in-none ActLoopNT-in 2.946 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.69 APE8-dihe-in -60.2, 108.92 APE8-rot-na 24.51 APE67-dihe-in -69.01, -26.9 -54.86, -33.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.181 M317L,T341M None None XRAY 2.582 0.211 0.266 B 286 264 12 0 0 12 [[270, 521]] 1.0 4mxy TYR_SRC_HUMAN TYR 5.7e-94 320.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXZA P12931 260 536 536.0 DB8:60601 Type1 Inactive DFGin 6.978 15.469 BLAminus -142.79, 170.65 62.95, 55.86 -70.4, 28.65 287.69, 79.24 -58.93, -6.93 in-out in 8.282 Saltbr-out 4.065 HRD-in -87.01, -42.61 78.79, -16.55 out-in-none SNCoin in-none ActLoopNT-in 3.007 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.72 APE8-dihe-in -52.37, 106.54 APE8-rot-na 27.67 APE67-dihe-in -73.74, -30.15 -77.33, -12.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.825 M317L,T341M None None XRAY 2.582 0.211 0.266 A 286 266 11 0 0 11 [[270, 521]] 1.0 4mxz TYR_SRC_HUMAN TYR 5.7e-94 320.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXZB P12931 261 536 536.0 DB8:60601 Type1 Inactive DFGin 7.454 15.832 BLAminus -129.72, -177.95 52.13, 75.68 -95.7, 22.45 293.45, 79.71 -64.73, -0.78 in-out in 8.476 Saltbr-out 4.823 HRD-in -98.19, -46.95 89.14, -36.87 out-in-none SNCoin in-none ActLoopNT-in 2.946 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.69 APE8-dihe-in -60.2, 108.92 APE8-rot-na 24.51 APE67-dihe-in -69.01, -26.9 -54.86, -33.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.181 M317L,T341M None None XRAY 2.582 0.211 0.266 B 286 264 12 0 0 12 [[270, 521]] 1.0 4mxz TYR_SRC_HUMAN TYR 5.7e-94 320.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXXA P12931 260 536 536.0 DB8:60601 Type1 Inactive DFGin 6.313 15.126 BLAminus -149.62, -161.02 61.42, 50.32 -80.39, 24.51 301.08, 87.62 -67.03, 2.62 in-out in 9.642 Saltbr-out 3.725 HRD-in -93.25, -45.08 83.85, -17.11 out-in-none SNCoin in-none ActLoopNT-in 3.284 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.01 APE8-dihe-in -65.56, 97.07 APE8-rot-na 27.85 APE67-dihe-in -51.41, -37.35 -66.58, -37.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.029 A406T None None XRAY 2.6 0.213 0.276 A 286 266 11 0 0 11 [[270, 521]] 1.0 4mxx TYR_SRC_HUMAN TYR 3.1e-94 321.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXOA P12931 260 536 536.0 DB8:60601 Type1 None DFGin 6.485 14.992 BLAminus -136.89, -177.13 60.13, 67.22 -88.08, 17.88 299.37, 80.4 -39.41, -49.93 in-in in 8.209 Saltbr-in 3.007 HRD-in -88.6, -49.05 78.24, -0.79 in-in-none SNCiin in-none ActLoopNT-in 2.923 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.4 APE8-dihe-in -68.65, 109.43 APE8-rot-na 30.28 APE67-dihe-in -65.46, -35.11 -60.6, -22.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.961 None None None XRAY 2.105 0.212 0.254 A 286 266 11 0 0 11 [[270, 521]] 1.0 4mxo TYR_SRC_HUMAN TYR 1.6e-94 322.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXOB P12931 261 536 536.0 DB8:60601 Type1 None DFGin 6.117 14.771 BLAminus -143.71, -172.1 53.51, 74.85 -94.55, 12.21 299.33, 86.01 -48.26, -39.95 in-in in 7.978 Saltbr-in 3.027 HRD-in -94.91, -49.82 82.99, -7.9 in-in-none SNCiin in-none ActLoopNT-in 2.965 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.53 APE8-dihe-in -48.6, 109.34 APE8-rot-na 16.54 APE67-dihe-in -71.78, -28.01 -62.09, -30.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.732 None None None XRAY 2.105 0.212 0.254 B 286 264 12 0 0 12 [[270, 521]] 1.0 4mxo TYR_SRC_HUMAN TYR 1.6e-94 322.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXXB P12931 261 536 536.0 DB8:60601 Type1 Inactive DFGinter 9.192 8.286 BABtrans -85.22, 126.66 -111.4, 38.55 -113.28, 121.97 179.79, 84.82 122.67, -27.99 out-out out 10.737 Saltbr-out 7.312 HRD-in -99.39, -46.07 76.64, -21.16 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.26 APE8-dihe-in -50.75, 100.65 APE8-rot-na 26.17 APE67-dihe-in -61.28, -28.71 -44.67, -43.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.954 A406T None None XRAY 2.6 0.213 0.276 B 286 260 16 0 0 16 [[270, 521]] 1.0 4mxx TYR_SRC_HUMAN TYR 3.1e-94 321.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src

Ligand: DB8 (Bosutinib, Bosulif)

Total number of chains: 26
Active chains: 1
Total number of genes: 12
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 17 65.4% 5VCYA
DFGin None 2 7.7% 5AJQA
DFGinter None 2 7.7% 9D5FA
DFGout None 2 7.7% 3UE4A
DFGin BLBminus 1 3.8% 5I9XA
DFGin BLBplus 1 3.8% 6OP9A
DFGinter BABtrans 1 3.8% 4MXXB
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK CAMK2A KCC2A_HUMAN 3SOAA Q9UQM7 7 474 478.0 DB8:60445 Type1 Inactive DFGinter 10.807 10.237 None -98.86, 109.77 -79.7, 114.69 -137.02, 147.48 315.53, 123.27 104.35, -23.23 in-na in 8.799 Saltbr-na 999.0 HRD-in -73.81, -41.57 68.14, -19.19 na-in-in SNCaii in-in ActLoopNT-in 3.181 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.13, 161.55 APE9-dihe-na 103.67, -177.05 APE8-dihe-in -98.78, 133.3 APE8-rot-in 301.55 APE67-dihe-in -73.82, -31.03 -42.95, -42.2 APE12-dist-in 9.829 APE11-dist-in 10.848 APE10-dist-in 5.275 APE9-dist-in 3.989 K42M,D135N,T306V None None XRAY 3.55 0.279 0.327 A 444 436 2 0 0 0 [[13, 271]] 1.0 3soa Homo sapiens CAMK_CAMK2A_HUMAN CAMK 2.8e-93 318.5 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK SIK3 SIK3_HUMAN 8R4QA Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.27 14.887 BLAminus -139.01, 171.07 65.51, 84.49 -98.95, 35.4 290.76, 86.17 -67.45, -37.73 in-out in 9.482 Saltbr-out 4.139 HRD-in -65.82, -56.46 69.69, -0.35 out-in-out SNCoio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.28, 159.93 APE9-dihe-na 142.02, 171.32 APE8-dihe-in -81.41, 117.57 APE8-rot-out 188.89 APE67-dihe-in -62.69, -24.82 -43.74, -50.05 APE12-dist-in 7.634 APE11-dist-in 11.009 APE10-dist-in 5.294 APE9-dist-in 3.232 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 A 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4QC Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.293 14.764 BLAminus -135.25, 170.61 66.71, 84.0 -99.07, 36.48 291.2, 85.91 -69.03, -37.82 in-out in 9.499 Saltbr-out 4.06 HRD-in -75.57, -57.14 68.81, -4.17 out-in-out SNCoio in-out ActLoopNT-in 2.89 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.57, 158.49 APE9-dihe-na 142.55, 170.52 APE8-dihe-in -81.5, 119.22 APE8-rot-out 55.54 APE67-dihe-in -62.66, -24.97 -44.86, -49.85 APE12-dist-in 7.616 APE11-dist-in 10.986 APE10-dist-in 5.263 APE9-dist-in 3.238 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 C 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4QE Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.31 14.801 BLAminus -139.98, 171.19 65.46, 83.84 -99.17, 35.86 291.35, 86.11 -68.1, -36.3 in-out in 9.532 Saltbr-out 4.096 HRD-in -73.14, -51.55 63.42, 1.74 out-in-out SNCoio in-out ActLoopNT-in 3.101 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.33, 159.33 APE9-dihe-na 142.87, 171.07 APE8-dihe-in -80.24, 117.39 APE8-rot-out 190.21 APE67-dihe-in -61.05, -42.7 -42.39, -51.02 APE12-dist-in 7.543 APE11-dist-in 10.939 APE10-dist-in 5.259 APE9-dist-in 3.332 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 E 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4QG Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.382 14.787 BLAminus -136.43, 170.69 66.72, 83.62 -98.78, 33.02 291.62, 86.44 -67.7, -37.12 in-out in 9.555 Saltbr-out 3.974 HRD-in -68.39, -50.34 62.72, 11.29 out-in-out SNCoio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.11, 159.76 APE9-dihe-na 140.64, 172.45 APE8-dihe-in -81.58, 117.44 APE8-rot-out 189.92 APE67-dihe-in -60.6, -25.5 -43.58, -51.63 APE12-dist-in 7.433 APE11-dist-in 10.791 APE10-dist-in 5.137 APE9-dist-in 3.243 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 G 328 320 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4QI Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.29 14.857 BLAminus -140.96, 171.42 64.9, 84.12 -97.96, 35.72 290.26, 86.39 -67.95, -38.18 in-out in 9.544 Saltbr-out 4.083 HRD-in -66.19, -52.55 62.88, 16.03 out-in-out SNCoio in-out ActLoopNT-in 2.935 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.02, 158.46 APE9-dihe-na 144.09, 168.25 APE8-dihe-in -80.55, 117.37 APE8-rot-out 188.41 APE67-dihe-in -62.44, -25.32 -44.55, -49.34 APE12-dist-in 7.633 APE11-dist-in 10.97 APE10-dist-in 5.248 APE9-dist-in 3.292 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 I 328 316 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4QK Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.303 14.862 BLAminus -130.99, 169.6 63.77, 94.11 -108.55, 39.14 294.05, 89.24 -69.02, -37.64 in-out in 9.921 Saltbr-out 5.202 HRD-in -62.64, -54.81 63.03, 15.84 out-in-out SNCoio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.45, 159.5 APE9-dihe-na 141.76, 170.37 APE8-dihe-in -80.52, 118.54 APE8-rot-out 187.31 APE67-dihe-in -62.28, -24.73 -43.25, -51.12 APE12-dist-in 7.521 APE11-dist-in 10.96 APE10-dist-in 5.223 APE9-dist-in 3.254 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 K 328 318 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
OTHER PKMYT1 PMYT1_HUMAN 5VCYA Q99640 77 362 499.0 DB8:60401 Type1 Inactive DFGin 5.969 14.359 BLAminus -127.91, -168.29 70.38, 72.35 -96.64, 23.14 300.41, 119.28 -68.58, -24.5 in-in in 8.714 Saltbr-in 2.719 HRD-in -69.32, -46.71 70.97, 0.9 in-in-out SNCiio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -97.27, 135.17 APE9-dihe-na -76.61, -179.9 APE8-dihe-in -57.88, 126.16 APE8-rot-na 189.14 APE67-dihe-in -62.75, -28.84 -62.08, -23.7 APE12-dist-in 8.015 APE11-dist-out 5.197 APE10-dist-out 9.02 APE9-dist-in 3.47 None None None XRAY 1.56 0.14 0.178 A 311 286 0 0 0 0 [[110, 359]] 1.0 5vcy Homo sapiens OTHER_PKMYT1_HUMAN STE 9.9e-39 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER ULK3 ULK3_HUMAN 6FDYU Q6PHR2 9 274 472.0 DB8:301,DB8:302 Type1,Allosteric Inactive DFGin 6.874 15.807 BLAminus -121.89, 168.03 58.05, 74.57 -82.78, 25.82 281.46, 65.78 -64.66, -23.35 out-out out 11.318 Saltbr-out 6.975 HRD-in -73.35, -48.54 71.13, 8.1 out-in-in SNCoii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.42, 135.02 APE9-dihe-na 116.19, -156.99 APE8-dihe-in -126.23, 135.32 APE8-rot-in 297.86 APE67-dihe-in -77.76, -4.76 -49.56, -42.9 APE12-dist-in 9.776 APE11-dist-in 10.466 APE10-dist-in 5.312 APE9-dist-in 3.261 None None None XRAY 1.7 0.207 0.239 U 276 262 4 0 0 0 [[14, 270]] 1.0 6fdy Homo sapiens OTHER_ULK3_HUMAN ULK 2.9e-126 426.0 1 256 256 156 157 158 160 162 44 62 66 134 136 135 137 195 183 178 177 176 175 174 173 172 92 Serine/threonine-protein kinase ULK3
OTHER WEE1 WEE1_HUMAN 5VC3A P30291 293 570 646.0 DB8:601 Type1 Inactive DFGin 5.869 13.847 BLAminus -114.82, -178.11 54.56, 79.37 -92.53, 24.23 299.17, 19.73 -68.72, -22.16 out-out out 10.357 Saltbr-out 5.286 HRD-in -86.82, -42.16 64.96, 14.12 out-in-out SNCoio in-out ActLoopNT-in 2.991 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -59.88, 134.71 APE9-dihe-na -71.82, -169.68 APE8-dihe-in -52.32, 129.97 APE8-rot-na 194.6 APE67-dihe-in -75.75, -17.17 -62.12, -24.88 APE12-dist-in 8.32 APE11-dist-out 5.181 APE10-dist-out 9.248 APE9-dist-in 3.434 None None None XRAY 1.97 0.212 0.254 A 289 260 18 0 0 0 [[299, 569]] 1.0 5vc3 Homo sapiens OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
STE STK10 STK10_HUMAN 5AJQA O94804 24 312 968.0 DB8:800 Type1 Inactive DFGin 6.259 15.744 None -120.59, 174.2 81.32, -56.36 57.24, 29.42 287.8, 79.18 102.53, -17.28 out-out out 10.748 Saltbr-out 10.947 HRD-in -68.33, -48.71 84.04, -21.17 out-out-out SNCooo out-out ActLoopNT-out 12.573 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -85.91, 130.23 APE9-dihe-na 91.1, 7.46 APE8-dihe-in -59.1, 130.74 APE8-rot-in 288.9 APE67-dihe-out -66.14, -20.66 -86.49, 69.24 APE12-dist-none 999.0 APE11-dist-out 18.692 APE10-dist-out 14.146 APE9-dist-out 10.682 None None None XRAY 2.2 0.219 0.257 A 295 280 9 0 0 6 [[36, 294]] 1.0 5ajq Homo sapiens STE_STK10_HUMAN STE 1.9e-94 321.7 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5AJQB O94804 25 312 968.0 DB8:800 Type1 Inactive DFGin 6.286 15.939 None -120.49, 173.38 83.25, -57.95 53.22, 23.51 288.78, 77.4 -62.81, -49.77 out-none out 10.89 Saltbr-none 999.0 HRD-in -69.73, -48.6 82.63, -20.29 none-out-none SNCnon out-none ActLoopNT-out 6.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 83.37 APE8-rot-in 290.95 APE67-dihe-in -67.97, -24.14 -101.21, 28.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.219 0.257 B 295 267 21 0 0 13 [[36, 294]] 1.0 5ajq Homo sapiens STE_STK10_HUMAN STE 1.9e-94 321.7 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK24 STK24_HUMAN 4QMNA Q9Y6E0 27 310 443.0 DB8:60401 Type1 Active DFGin 6.754 15.582 BLAminus -132.67, 174.27 64.71, 80.09 -95.84, 30.95 285.18, 68.8 -57.26, -28.92 in-in in 9.748 Saltbr-in 3.524 HRD-in -76.5, -47.9 71.96, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.707 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 157.72 APE9-dihe-na 133.63, -173.45 APE8-dihe-in -111.31, 120.57 APE8-rot-in 310.4 APE67-dihe-in -59.08, -29.88 -38.92, -51.65 APE12-dist-in 8.326 APE11-dist-in 10.884 APE10-dist-in 5.068 APE9-dist-in 3.36 None TPO190 TPO190 XRAY 2.091 0.179 0.227 A 310 284 0 0 0 0 [[36, 286]] 1.0 4qmn Homo sapiens STE_STK24_HUMAN STE 3.9e-100 340.4 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TKL ILK ILK_HUMAN 9D5FA Q13418 182 452 452.0 DB8:501 Type1 Pseudo DFGinter 8.366 7.592 None -82.6, 123.95 -74.1, -11.79 -66.74, -13.57 999.0, 999.0 -72.54, 5.75 out-out out 14.123 Saltbr-out 15.4 HRD-out -123.23, 159.13 -69.32, -46.01 out-out-out SNCooo out-out ActLoopNT-out 5.554 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -109.48, 117.62 APE9-dihe-na -102.03, -10.5 APE8-dihe-in -134.11, 56.74 APE8-rot-none 999.0 APE67-dihe-in -63.21, -21.45 -62.91, -18.33 APE12-dist-out 15.638 APE11-dist-out 14.874 APE10-dist-out 14.406 APE9-dist-out 8.782 C346S,C422S None None XRAY 1.5 0.191 0.208 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5f Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TYR ABL1 ABL1_HUMAN 3UE4A P00519 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.471 10.087 None -73.57, 139.68 -129.47, 18.74 -70.04, -27.22 71.97, 85.11 -97.86, 45.9 in-out in 8.122 Saltbr-out 4.005 HRD-out -105.15, 128.48 -83.8, -2.91 out-out-in SNCooi out-in ActLoopNT-out 5.294 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.88, 137.39 APE9-dihe-in -119.63, 157.7 APE8-dihe-in -69.93, 97.57 APE8-rot-na 25.4 APE67-dihe-in -65.99, -15.91 -45.97, -49.68 APE12-dist-na 19.211 APE11-dist-na 14.469 APE10-dist-na 17.122 APE9-dist-in 6.836 None None None XRAY 2.424 0.192 0.249 A 287 270 0 0 0 0 [[242, 495]] 1.0 3ue4 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3UE4B P00519 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.224 10.48 None -68.43, 143.68 -139.88, 24.33 -73.48, -36.67 65.16, 97.6 -93.69, 7.14 in-out in 8.491 Saltbr-out 3.771 HRD-in -88.28, -56.6 76.68, -0.41 out-out-in SNCooi out-in ActLoopNT-out 5.441 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.79, 122.21 APE9-dihe-in -108.43, 151.01 APE8-dihe-in -71.16, 105.45 APE8-rot-na 24.97 APE67-dihe-in -72.18, -12.67 -59.58, -44.17 APE12-dist-na 19.453 APE11-dist-na 14.748 APE10-dist-na 17.212 APE9-dist-in 6.892 None None None XRAY 2.424 0.192 0.249 B 287 268 2 0 0 0 [[242, 495]] 1.0 3ue4 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR EPHA2 EPHA2_HUMAN 5I9XA P29317 604 896 976.0 DB8:1001 Type1 Inactive DFGin 6.007 14.831 BLBminus -129.07, 177.72 76.64, 79.94 -112.75, 156.99 297.29, 98.79 146.97, -174.61 in-in in 8.09 Saltbr-in 3.299 HRD-in -74.57, -46.21 76.15, -16.23 in-out-in SNCioi out-in ActLoopNT-out 10.42 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.78, 113.1 APE9-dihe-in -147.01, 138.26 APE8-dihe-in -78.55, 92.56 APE8-rot-na 31.7 APE67-dihe-in -77.79, -2.98 -59.26, -48.48 APE12-dist-na 999.0 APE11-dist-na 14.091 APE10-dist-na 12.379 APE9-dist-in 6.799 None None None XRAY 1.427 0.166 0.182 A 306 284 9 0 0 4 [[613, 873]] 1.0 5i9x Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR ERBB3 ERBB3_HUMAN 6OP9A P21860 699 979 1342.0 DB8:61101 Type1 Pseudo DFGin 5.807 13.202 BLBplus -112.2, 168.23 74.7, 17.55 -72.83, 138.03 47.72, 93.08 81.75, -11.37 out-na out 15.256 Saltbr-na 999.0 HRD-in -65.5, -60.79 78.74, 0.36 na-out-out SNCaoo out-out ActLoopNT-out 6.69 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -72.9, -25.26 APE9-dihe-in -116.6, 159.4 APE8-dihe-in -83.21, 75.09 APE8-rot-na 31.73 APE67-dihe-in -70.29, -6.2 -48.51, -45.47 APE12-dist-na 999.0 APE11-dist-na 18.44 APE10-dist-na 14.221 APE9-dist-in 7.834 None None None XRAY 2.501 0.173 0.23 A 328 276 5 0 0 5 [[709, 967]] 1.0 6op9 Homo sapiens TYR_ERBB3_HUMAN TYR 6.2e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR SRC SRC_HUMAN 4MXYA P12931 260 536 536.0 DB8:60601 Type1 Inactive DFGin 6.978 15.469 BLAminus -142.79, 170.65 62.95, 55.86 -70.4, 28.65 287.69, 79.24 -58.93, -6.93 in-out in 8.282 Saltbr-out 4.065 HRD-in -87.01, -42.61 78.79, -16.55 out-in-none SNCoin in-none ActLoopNT-in 3.007 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.72 APE8-dihe-in -52.37, 106.54 APE8-rot-na 27.67 APE67-dihe-in -73.74, -30.15 -77.33, -12.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.825 M317L,T341M None None XRAY 2.582 0.211 0.266 A 286 266 11 0 0 11 [[270, 521]] 1.0 4mxy Homo sapiens TYR_SRC_HUMAN TYR 5.7e-94 320.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXYB P12931 261 536 536.0 DB8:60601 Type1 Inactive DFGin 7.454 15.832 BLAminus -129.72, -177.95 52.13, 75.68 -95.7, 22.45 293.45, 79.71 -64.73, -0.78 in-out in 8.476 Saltbr-out 4.823 HRD-in -98.19, -46.95 89.14, -36.87 out-in-none SNCoin in-none ActLoopNT-in 2.946 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.69 APE8-dihe-in -60.2, 108.92 APE8-rot-na 24.51 APE67-dihe-in -69.01, -26.9 -54.86, -33.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.181 M317L,T341M None None XRAY 2.582 0.211 0.266 B 286 264 12 0 0 12 [[270, 521]] 1.0 4mxy Homo sapiens TYR_SRC_HUMAN TYR 5.7e-94 320.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXZA P12931 260 536 536.0 DB8:60601 Type1 Inactive DFGin 6.978 15.469 BLAminus -142.79, 170.65 62.95, 55.86 -70.4, 28.65 287.69, 79.24 -58.93, -6.93 in-out in 8.282 Saltbr-out 4.065 HRD-in -87.01, -42.61 78.79, -16.55 out-in-none SNCoin in-none ActLoopNT-in 3.007 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.72 APE8-dihe-in -52.37, 106.54 APE8-rot-na 27.67 APE67-dihe-in -73.74, -30.15 -77.33, -12.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.825 M317L,T341M None None XRAY 2.582 0.211 0.266 A 286 266 11 0 0 11 [[270, 521]] 1.0 4mxz Homo sapiens TYR_SRC_HUMAN TYR 5.7e-94 320.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXZB P12931 261 536 536.0 DB8:60601 Type1 Inactive DFGin 7.454 15.832 BLAminus -129.72, -177.95 52.13, 75.68 -95.7, 22.45 293.45, 79.71 -64.73, -0.78 in-out in 8.476 Saltbr-out 4.823 HRD-in -98.19, -46.95 89.14, -36.87 out-in-none SNCoin in-none ActLoopNT-in 2.946 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.69 APE8-dihe-in -60.2, 108.92 APE8-rot-na 24.51 APE67-dihe-in -69.01, -26.9 -54.86, -33.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.181 M317L,T341M None None XRAY 2.582 0.211 0.266 B 286 264 12 0 0 12 [[270, 521]] 1.0 4mxz Homo sapiens TYR_SRC_HUMAN TYR 5.7e-94 320.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXXA P12931 260 536 536.0 DB8:60601 Type1 Inactive DFGin 6.313 15.126 BLAminus -149.62, -161.02 61.42, 50.32 -80.39, 24.51 301.08, 87.62 -67.03, 2.62 in-out in 9.642 Saltbr-out 3.725 HRD-in -93.25, -45.08 83.85, -17.11 out-in-none SNCoin in-none ActLoopNT-in 3.284 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.01 APE8-dihe-in -65.56, 97.07 APE8-rot-na 27.85 APE67-dihe-in -51.41, -37.35 -66.58, -37.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.029 A406T None None XRAY 2.6 0.213 0.276 A 286 266 11 0 0 11 [[270, 521]] 1.0 4mxx Homo sapiens TYR_SRC_HUMAN TYR 3.1e-94 321.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXOA P12931 260 536 536.0 DB8:60601 Type1 None DFGin 6.485 14.992 BLAminus -136.89, -177.13 60.13, 67.22 -88.08, 17.88 299.37, 80.4 -39.41, -49.93 in-in in 8.209 Saltbr-in 3.007 HRD-in -88.6, -49.05 78.24, -0.79 in-in-none SNCiin in-none ActLoopNT-in 2.923 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.4 APE8-dihe-in -68.65, 109.43 APE8-rot-na 30.28 APE67-dihe-in -65.46, -35.11 -60.6, -22.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.961 None None None XRAY 2.105 0.212 0.254 A 286 266 11 0 0 11 [[270, 521]] 1.0 4mxo Homo sapiens TYR_SRC_HUMAN TYR 1.6e-94 322.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXOB P12931 261 536 536.0 DB8:60601 Type1 None DFGin 6.117 14.771 BLAminus -143.71, -172.1 53.51, 74.85 -94.55, 12.21 299.33, 86.01 -48.26, -39.95 in-in in 7.978 Saltbr-in 3.027 HRD-in -94.91, -49.82 82.99, -7.9 in-in-none SNCiin in-none ActLoopNT-in 2.965 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.53 APE8-dihe-in -48.6, 109.34 APE8-rot-na 16.54 APE67-dihe-in -71.78, -28.01 -62.09, -30.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.732 None None None XRAY 2.105 0.212 0.254 B 286 264 12 0 0 12 [[270, 521]] 1.0 4mxo Homo sapiens TYR_SRC_HUMAN TYR 1.6e-94 322.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXXB P12931 261 536 536.0 DB8:60601 Type1 Inactive DFGinter 9.192 8.286 BABtrans -85.22, 126.66 -111.4, 38.55 -113.28, 121.97 179.79, 84.82 122.67, -27.99 out-out out 10.737 Saltbr-out 7.312 HRD-in -99.39, -46.07 76.64, -21.16 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.26 APE8-dihe-in -50.75, 100.65 APE8-rot-na 26.17 APE67-dihe-in -61.28, -28.71 -44.67, -43.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.954 A406T None None XRAY 2.6 0.213 0.276 B 286 260 16 0 0 16 [[270, 521]] 1.0 4mxx Homo sapiens TYR_SRC_HUMAN TYR 3.1e-94 321.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src

Ligand: DB8 (Bosutinib, Bosulif)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name