Ligand: ADE

Total number of chains: 6
Active chains: 5
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 100.0% 5LVMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC PDPK1 PDPK1_HUMAN 5LVMA 1.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
CAMK CHEK1 CHK1_HUMAN 7BKNA 2.74 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 7 - 271 0 None None Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BJEA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 4 - 270 0 None N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S Serine/threonine-protein kinase Chk1
STE STK24 STK24_HUMAN 3A7IA 1.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 25 - 311 0 TPO190 None Serine/threonine-protein kinase 24
TKL ACVR2B AVR2B_HUMAN 2QLUA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 190 - 484 0 None None Activin receptor type-2B
TYR RET RET_HUMAN 6NJAA 1.92 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADE Type1 705 - 1013 0 PTR900,PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret

Ligand: ADE

Total number of chains: 9
Active chains: 7
Total number of genes: 8
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 100.0% 5LVMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PRKACA KAPCA_CRIGR 6Y05A 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 8 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PDPK1 PDPK1_HUMAN 5LVMA 1.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
CAMK CHEK1 CHK1_HUMAN 7BKNA 2.74 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 7 - 271 0 None None Serine/threonine-protein kinase Chk1 Homo sapiens
CAMK CHEK1 CHK1_HUMAN 7BJEA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 4 - 270 0 None N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S Serine/threonine-protein kinase Chk1 Homo sapiens
STE STK24 STK24_HUMAN 3A7IA 1.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 25 - 311 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
TKL ACVR2B AVR2B_HUMAN 2QLUA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 190 - 484 0 None None Activin receptor type-2B Homo sapiens
TYR RET RET_HUMAN 6NJAA 1.92 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADE Type1 705 - 1013 0 PTR900,PTR905 None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
AGC PRKCI KPCI_MOUSE 4DC2A 2.4 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 248 - 586 0 TPO563 None Protein kinase C iota type Mus musculus
CMGC SKY1 SKY1_YEAST 1Q8YB 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 146 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae

Ligand: ADE

Total number of chains: 3
Active chains: 2
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6Y05A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PRKACA KAPCA_CRIGR 6Y05A 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 8 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKCI KPCI_MOUSE 4DC2A 2.4 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 248 - 586 0 TPO563 None Protein kinase C iota type Mus musculus
CMGC SKY1 SKY1_YEAST 1Q8YB 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 146 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae