KinCore

Ligand: 4BM (Mirdametinib, Gomekli)

Total number of chains: 5

Active chains: 0

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLBplus	5	100.0%	3EQGA

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
STE	MAP2K1	MP2K1_HUMAN	3VVHA	Q02750	62	382	393.0	ATP:60702,4BM:60703	ATPlike,Type3	Inactive	DFGin	6.389	13.656	BLBplus	-137.53, 173.5	63.48, 33.18	-82.96, 158.78	37.49, 96.63	-83.81, 69.64	out-out	out	15.318	Saltbr-out	14.947	HRD-in	-72.04, -55.34	81.65, -10.46	out-out-out	SNCooo	out-out	ActLoopNT-out	9.261	ActLoopCT-out	nonTYR	APEdihe_aanio	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, -67.32	APE8-rot-in	311.04	APE67-dihe-out	-121.47, 130.33	-95.91, 138.68	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.0	0.199	0.225	A	341	286	35	0	0	5	[[68, 361]]	1.0	3vvh	STE_MAP2K1_HUMAN	STE	1.5e-97	331.9	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1
STE	MAP2K1	MP2K1_HUMAN	3VVHB	Q02750	62	382	393.0	ATP:60502,4BM:60503	ATPlike,Type3	Inactive	DFGin	6.139	13.837	BLBplus	-134.79, 175.55	59.54, 35.53	-87.99, 165.28	42.27, 92.99	-92.68, 76.34	out-out	out	15.261	Saltbr-out	14.977	HRD-in	-72.52, -58.36	78.03, -3.83	out-out-out	SNCooo	out-out	ActLoopNT-out	9.105	ActLoopCT-out	nonTYR	APEdihe_aaoio	APEdist_oooo	APE10-dihe-na	-110.08, 147.03	APE9-dihe-na	98.19, 168.29	APE8-dihe-out	-85.55, -32.58	APE8-rot-in	303.1	APE67-dihe-out	-124.7, 138.59	-110.8, 145.07	APE12-dist-out	16.971	APE11-dist-out	20.559	APE10-dist-out	18.851	APE9-dist-out	12.926	None	None	None	XRAY	2.0	0.199	0.225	B	341	289	32	0	0	0	[[68, 361]]	1.0	3vvh	STE_MAP2K1_HUMAN	STE	1.5e-97	331.9	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1
STE	MAP2K1	MP2K1_HUMAN	3VVHC	Q02750	62	381	393.0	ATP:60502,4BM:60503	ATPlike,Type3	Inactive	DFGin	6.119	13.884	BLBplus	-136.04, 173.19	62.4, 33.8	-87.32, 164.72	43.72, 90.03	-81.06, 61.43	out-out	out	15.395	Saltbr-out	14.906	HRD-in	-71.92, -60.52	80.82, -10.24	out-out-out	SNCooo	out-out	ActLoopNT-out	9.005	ActLoopCT-out	nonTYR	APEdihe_aaooo	APEdist_oooo	APE10-dihe-na	-107.33, 145.59	APE9-dihe-na	98.43, 176.47	APE8-dihe-out	-99.48, -17.12	APE8-rot-out	62.73	APE67-dihe-out	-124.21, 136.5	-120.29, 144.56	APE12-dist-out	16.918	APE11-dist-out	20.623	APE10-dist-out	18.804	APE9-dist-out	12.965	None	None	None	XRAY	2.0	0.199	0.225	C	341	282	38	0	0	0	[[68, 361]]	1.0	3vvh	STE_MAP2K1_HUMAN	STE	1.5e-97	331.9	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1
STE	MAP2K1	MP2K1_HUMAN	3EQGA	Q02750	39	381	393.0	ADP:2,4BM:1	ATPlike,Type3	Inactive	DFGin	6.606	13.743	BLBplus	-138.18, 179.2	59.31, 28.5	-81.55, 153.56	35.8, 92.23	-71.67, 64.14	out-out	out	15.474	Saltbr-out	14.566	HRD-in	-60.95, -65.33	94.63, -12.32	out-out-out	SNCooo	out-out	ActLoopNT-out	9.231	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-104.38, 152.44	APE9-dihe-na	-137.47, 114.08	APE8-dihe-in	-13.21, 123.19	APE8-rot-out	216.51	APE67-dihe-in	-71.17, -7.71	-101.04, 15.41	APE12-dist-out	19.79	APE11-dist-out	16.56	APE10-dist-out	18.855	APE9-dist-out	9.489	S298N,S299K,Y300F	None	None	XRAY	2.5	0.21	0.273	A	360	314	29	0	0	0	[[68, 361]]	1.0	3eqg	STE_MAP2K1_HUMAN	STE	1.8e-97	331.7	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1
STE	MAP2K1	MP2K1_HUMAN	7M0XB	Q02750	40	383	393.0	ANP:801,4BM:803	ATPlike,Type3	Inactive	DFGin	6.04	13.707	BLBplus	-145.13, 173.52	62.48, 32.29	-85.3, 166.26	43.84, 89.91	-82.62, 63.8	out-out	out	15.219	Saltbr-out	15.128	HRD-in	-57.93, -57.46	71.94, -0.74	out-out-out	SNCooo	out-out	ActLoopNT-out	8.331	ActLoopCT-out	nonTYR	APEdihe_aaooo	APEdist_oooo	APE10-dihe-na	-140.02, 147.44	APE9-dihe-na	-87.47, -179.23	APE8-dihe-out	-111.82, -15.11	APE8-rot-out	56.07	APE67-dihe-out	-151.04, 140.91	-141.23, 175.81	APE12-dist-out	17.795	APE11-dist-out	17.919	APE10-dist-out	21.393	APE9-dist-out	11.986	S218A,S222A	None	None	XRAY	2.47	0.18	0.215	B	397	312	32	0	0	0	[[68, 361]]	1.0	7m0x	STE_MAP2K1_HUMAN	STE	1.1e-96	329.2	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1

Ligand: 4BM (Mirdametinib, Gomekli)

Total number of chains: 7

Active chains: 0

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLBplus	7	100.0%	3EQGA

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
STE	MAP2K1	MP2K1_HUMAN	3VVHA	Q02750	62	382	393.0	ATP:60702,4BM:60703	ATPlike,Type3	Inactive	DFGin	6.389	13.656	BLBplus	-137.53, 173.5	63.48, 33.18	-82.96, 158.78	37.49, 96.63	-83.81, 69.64	out-out	out	15.318	Saltbr-out	14.947	HRD-in	-72.04, -55.34	81.65, -10.46	out-out-out	SNCooo	out-out	ActLoopNT-out	9.261	ActLoopCT-out	nonTYR	APEdihe_aanio	APEdist_nnnn	APE10-dihe-na	999.0, 999.0	APE9-dihe-na	999.0, 999.0	APE8-dihe-none	999.0, -67.32	APE8-rot-in	311.04	APE67-dihe-out	-121.47, 130.33	-95.91, 138.68	APE12-dist-none	999.0	APE11-dist-none	999.0	APE10-dist-none	999.0	APE9-dist-none	999.0	None	None	None	XRAY	2.0	0.199	0.225	A	341	286	35	0	0	5	[[68, 361]]	1.0	3vvh	Homo sapiens	STE_MAP2K1_HUMAN	STE	1.5e-97	331.9	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1
STE	MAP2K1	MP2K1_HUMAN	3VVHB	Q02750	62	382	393.0	ATP:60502,4BM:60503	ATPlike,Type3	Inactive	DFGin	6.139	13.837	BLBplus	-134.79, 175.55	59.54, 35.53	-87.99, 165.28	42.27, 92.99	-92.68, 76.34	out-out	out	15.261	Saltbr-out	14.977	HRD-in	-72.52, -58.36	78.03, -3.83	out-out-out	SNCooo	out-out	ActLoopNT-out	9.105	ActLoopCT-out	nonTYR	APEdihe_aaoio	APEdist_oooo	APE10-dihe-na	-110.08, 147.03	APE9-dihe-na	98.19, 168.29	APE8-dihe-out	-85.55, -32.58	APE8-rot-in	303.1	APE67-dihe-out	-124.7, 138.59	-110.8, 145.07	APE12-dist-out	16.971	APE11-dist-out	20.559	APE10-dist-out	18.851	APE9-dist-out	12.926	None	None	None	XRAY	2.0	0.199	0.225	B	341	289	32	0	0	0	[[68, 361]]	1.0	3vvh	Homo sapiens	STE_MAP2K1_HUMAN	STE	1.5e-97	331.9	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1
STE	MAP2K1	MP2K1_HUMAN	3VVHC	Q02750	62	381	393.0	ATP:60502,4BM:60503	ATPlike,Type3	Inactive	DFGin	6.119	13.884	BLBplus	-136.04, 173.19	62.4, 33.8	-87.32, 164.72	43.72, 90.03	-81.06, 61.43	out-out	out	15.395	Saltbr-out	14.906	HRD-in	-71.92, -60.52	80.82, -10.24	out-out-out	SNCooo	out-out	ActLoopNT-out	9.005	ActLoopCT-out	nonTYR	APEdihe_aaooo	APEdist_oooo	APE10-dihe-na	-107.33, 145.59	APE9-dihe-na	98.43, 176.47	APE8-dihe-out	-99.48, -17.12	APE8-rot-out	62.73	APE67-dihe-out	-124.21, 136.5	-120.29, 144.56	APE12-dist-out	16.918	APE11-dist-out	20.623	APE10-dist-out	18.804	APE9-dist-out	12.965	None	None	None	XRAY	2.0	0.199	0.225	C	341	282	38	0	0	0	[[68, 361]]	1.0	3vvh	Homo sapiens	STE_MAP2K1_HUMAN	STE	1.5e-97	331.9	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1
STE	MAP2K1	MP2K1_HUMAN	3EQGA	Q02750	39	381	393.0	ADP:2,4BM:1	ATPlike,Type3	Inactive	DFGin	6.606	13.743	BLBplus	-138.18, 179.2	59.31, 28.5	-81.55, 153.56	35.8, 92.23	-71.67, 64.14	out-out	out	15.474	Saltbr-out	14.566	HRD-in	-60.95, -65.33	94.63, -12.32	out-out-out	SNCooo	out-out	ActLoopNT-out	9.231	ActLoopCT-out	nonTYR	APEdihe_aaioi	APEdist_oooo	APE10-dihe-na	-104.38, 152.44	APE9-dihe-na	-137.47, 114.08	APE8-dihe-in	-13.21, 123.19	APE8-rot-out	216.51	APE67-dihe-in	-71.17, -7.71	-101.04, 15.41	APE12-dist-out	19.79	APE11-dist-out	16.56	APE10-dist-out	18.855	APE9-dist-out	9.489	S298N,S299K,Y300F	None	None	XRAY	2.5	0.21	0.273	A	360	314	29	0	0	0	[[68, 361]]	1.0	3eqg	Homo sapiens	STE_MAP2K1_HUMAN	STE	1.8e-97	331.7	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1
STE	MAP2K1	MP2K1_HUMAN	7M0XB	Q02750	40	383	393.0	ANP:801,4BM:803	ATPlike,Type3	Inactive	DFGin	6.04	13.707	BLBplus	-145.13, 173.52	62.48, 32.29	-85.3, 166.26	43.84, 89.91	-82.62, 63.8	out-out	out	15.219	Saltbr-out	15.128	HRD-in	-57.93, -57.46	71.94, -0.74	out-out-out	SNCooo	out-out	ActLoopNT-out	8.331	ActLoopCT-out	nonTYR	APEdihe_aaooo	APEdist_oooo	APE10-dihe-na	-140.02, 147.44	APE9-dihe-na	-87.47, -179.23	APE8-dihe-out	-111.82, -15.11	APE8-rot-out	56.07	APE67-dihe-out	-151.04, 140.91	-141.23, 175.81	APE12-dist-out	17.795	APE11-dist-out	17.919	APE10-dist-out	21.393	APE9-dist-out	11.986	S218A,S222A	None	None	XRAY	2.47	0.18	0.215	B	397	312	32	0	0	0	[[68, 361]]	1.0	7m0x	Homo sapiens	STE_MAP2K1_HUMAN	STE	1.1e-96	329.2	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1
STE	MAP2K1	MP2K1_RABIT	7JUUC	P29678	43	381	393.0	ANP:401,4BM:402	ATPlike,Type3	Inactive	DFGin	6.574	14.008	BLBplus	-143.65, 177.32	57.69, 37.46	-92.33, 152.26	41.94, 94.89	-75.77, 92.54	out-out	out	15.833	Saltbr-out	14.739	HRD-in	-70.37, -49.34	74.88, -6.99	out-out-out	SNCooo	out-out	ActLoopNT-out	9.336	ActLoopCT-out	nonTYR	APEdihe_aaooo	APEdist_oooo	APE10-dihe-na	-102.48, 121.01	APE9-dihe-na	-118.18, -151.72	APE8-dihe-out	-92.91, -15.39	APE8-rot-out	41.03	APE67-dihe-out	-126.24, 128.64	-103.62, 122.66	APE12-dist-out	16.812	APE11-dist-out	19.575	APE10-dist-out	21.5	APE9-dist-out	14.815	None	None	None	XRAY	3.19	0.242	0.258	C	384	302	37	0	0	0	[[68, 361]]	1.0	7juu	Oryctolagus cuniculus	STE_MAP2K1_RABIT	STE	2.3e-97	331.4	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1
STE	MAP2K1	MP2K1_RABIT	7JV0C	P29678	40	382	393.0	ANP:401,4BM:402	ATPlike,Type3	Inactive	DFGin	5.873	14.27	BLBplus	-118.46, 167.04	65.91, 31.94	-77.55, 158.19	54.28, 101.68	-82.73, 82.06	out-out	out	16.445	Saltbr-out	16.87	HRD-in	-78.95, -48.37	72.45, 0.0	out-out-out	SNCooo	out-out	ActLoopNT-out	8.977	ActLoopCT-out	nonTYR	APEdihe_aaooo	APEdist_oooo	APE10-dihe-na	-134.69, 127.82	APE9-dihe-na	-92.23, -161.01	APE8-dihe-out	-91.79, -17.2	APE8-rot-out	194.87	APE67-dihe-out	-131.33, 129.9	-118.91, 161.4	APE12-dist-out	17.567	APE11-dist-out	16.919	APE10-dist-out	20.798	APE9-dist-out	12.679	None	None	None	XRAY	3.63	0.247	0.26	C	384	308	35	0	0	0	[[68, 361]]	1.0	7jv0	Oryctolagus cuniculus	STE_MAP2K1_RABIT	STE	2.3e-97	331.4	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1

Ligand: 4BM (Mirdametinib, Gomekli)

Total number of chains: 2

Active chains: 0

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLBplus	2	100.0%	7JV0C

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
STE	MAP2K1	MP2K1_RABIT	7JUUC	P29678	43	381	393.0	ANP:401,4BM:402	ATPlike,Type3	Inactive	DFGin	6.574	14.008	BLBplus	-143.65, 177.32	57.69, 37.46	-92.33, 152.26	41.94, 94.89	-75.77, 92.54	out-out	out	15.833	Saltbr-out	14.739	HRD-in	-70.37, -49.34	74.88, -6.99	out-out-out	SNCooo	out-out	ActLoopNT-out	9.336	ActLoopCT-out	nonTYR	APEdihe_aaooo	APEdist_oooo	APE10-dihe-na	-102.48, 121.01	APE9-dihe-na	-118.18, -151.72	APE8-dihe-out	-92.91, -15.39	APE8-rot-out	41.03	APE67-dihe-out	-126.24, 128.64	-103.62, 122.66	APE12-dist-out	16.812	APE11-dist-out	19.575	APE10-dist-out	21.5	APE9-dist-out	14.815	None	None	None	XRAY	3.19	0.242	0.258	C	384	302	37	0	0	0	[[68, 361]]	1.0	7juu	Oryctolagus cuniculus	STE_MAP2K1_RABIT	STE	2.3e-97	331.4	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1
STE	MAP2K1	MP2K1_RABIT	7JV0C	P29678	40	382	393.0	ANP:401,4BM:402	ATPlike,Type3	Inactive	DFGin	5.873	14.27	BLBplus	-118.46, 167.04	65.91, 31.94	-77.55, 158.19	54.28, 101.68	-82.73, 82.06	out-out	out	16.445	Saltbr-out	16.87	HRD-in	-78.95, -48.37	72.45, 0.0	out-out-out	SNCooo	out-out	ActLoopNT-out	8.977	ActLoopCT-out	nonTYR	APEdihe_aaooo	APEdist_oooo	APE10-dihe-na	-134.69, 127.82	APE9-dihe-na	-92.23, -161.01	APE8-dihe-out	-91.79, -17.2	APE8-rot-out	194.87	APE67-dihe-out	-131.33, 129.9	-118.91, 161.4	APE12-dist-out	17.567	APE11-dist-out	16.919	APE10-dist-out	20.798	APE9-dist-out	12.679	None	None	None	XRAY	3.63	0.247	0.26	C	384	308	35	0	0	0	[[68, 361]]	1.0	7jv0	Oryctolagus cuniculus	STE_MAP2K1_RABIT	STE	2.3e-97	331.4	1	257	257	207	208	209	211	213	97	114	118	187	189	188	190	245	233	228	227	226	225	224	223	222	144	Dual specificity mitogen-activated protein kinase kinase 1