Ligand: 38O (Dovitinib)

Total number of chains: 14
Active chains: 0
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 7 50.0% 5A46B
DFGin None 4 28.6% 7QQ6B
None None 2 14.3% 5OWQB
DFGin BLAminus 1 7.1% 7AKGA

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK STK17B ST17B_HUMAN 7AKGA O94768 25 309 372.0 38O:60406 Type1 Inactive DFGin 5.926 14.467 BLAminus -130.72, 166.63 65.44, 83.59 -95.88, 22.94 288.63, 83.5 -68.92, -24.29 in-in in 9.846 Saltbr-in 2.802 HRD-in -68.61, -50.56 69.3, 6.9 in-in-out SNCiio in-out ActLoopNT-in 2.98 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -106.87, 75.89 APE9-dihe-na -112.61, -152.27 APE8-dihe-in -87.24, 116.8 APE8-rot-in 316.03 APE67-dihe-in -74.45, -15.03 -47.64, -40.28 APE12-dist-in 7.984 APE11-dist-in 12.31 APE10-dist-out 10.545 APE9-dist-out 6.752 None None None XRAY 2.08 0.187 0.219 A 327 285 0 0 0 0 [[32, 293]] 1.0 7akg CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6A Q9P2K8 584 1004 1649.0 38O:1701 Type1 Inactive DFGin 4.545 13.832 None -64.42, 179.79 -78.36, -177.52 -104.81, 135.74 11.85, 74.61 -87.56, 999.0 out-out out 10.404 Saltbr-out 7.228 HRD-in -78.55, -45.81 67.95, -11.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -139.37, 156.89 APE9-dihe-na 68.88, -136.49 APE8-dihe-out -63.0, -22.3 APE8-rot-out 54.98 APE67-dihe-in -64.33, -22.31 -64.88, -30.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.309 D848N None None XRAY 2.8 0.213 0.258 A 320 269 26 0 0 20 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6B Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.743 14.437 None -62.22, 177.25 -71.17, -177.31 -113.77, 112.84 16.57, 83.07 -117.04, 75.83 out-out out 10.63 Saltbr-out 6.773 HRD-in -73.84, -58.14 68.49, 11.03 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -145.51, 135.89 APE9-dihe-na 67.14, -114.96 APE8-dihe-out -68.69, -35.73 APE8-rot-out 40.19 APE67-dihe-in -61.7, -18.1 -60.4, -26.4 APE12-dist-out 22.808 APE11-dist-out 18.791 APE10-dist-out 18.981 APE9-dist-out 12.646 D848N None None XRAY 2.8 0.213 0.258 B 320 275 22 0 0 18 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6C Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 5.153 15.331 None -67.88, 178.26 -74.84, 168.69 -62.36, -56.97 309.72, 121.46 57.54, 31.05 out-out out 10.431 Saltbr-out 6.787 HRD-in -71.08, -48.65 67.11, -5.82 out-out-out SNCooo out-out ActLoopNT-out 7.73 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 103.35 APE8-dihe-out -115.25, -20.91 APE8-rot-out 51.72 APE67-dihe-in -84.71, -19.81 -111.62, 33.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.792 D848N None None XRAY 2.8 0.213 0.258 C 320 267 30 0 0 29 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6D Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.793 14.782 None -71.0, 172.41 -73.73, 163.04 -66.19, -82.98 327.33, 91.13 74.54, 67.6 out-out out 11.102 Saltbr-out 6.778 HRD-in -68.97, -46.58 79.03, -46.68 out-out-none SNCoon out-none ActLoopNT-out 6.505 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.25, -17.58 999.0, -55.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.8 0.213 0.258 D 320 260 37 0 0 29 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
STE STK10 STK10_HUMAN 5OWQA O94804 30 317 968.0 38O:600 Type1 Inactive None 999.0 999.0 None -110.03, 168.4 44.48, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 10.669 Saltbr-none 999.0 HRD-in -81.59, -60.25 72.43, 10.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -97.79, -7.31 999.0, 33.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.265 0.305 A 302 255 33 0 0 20 [[36, 294]] 1.0 5owq STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5OWQB O94804 32 317 968.0 38O:600 Type1 Inactive None 999.0 999.0 None -111.67, 174.73 56.37, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.674 Saltbr-out 5.294 HRD-in -80.32, -59.59 72.13, 11.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -98.8, -4.63 999.0, 29.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.265 0.305 B 302 254 32 0 0 20 [[36, 294]] 1.0 5owq STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
TYR FGFR1 FGFR1_HUMAN 5AM7A P11362 458 764 822.0 38O:1000 Type1 Inactive DFGin 5.322 13.404 BLAplus -119.96, 160.03 61.93, 31.32 -78.06, -16.68 51.95, 91.0 -102.88, 8.06 in-in in 7.784 Saltbr-in 2.821 HRD-in -72.13, -53.65 81.66, -13.87 in-out-out SNCioo out-out ActLoopNT-out 8.844 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.07, 161.69 APE9-dihe-in -97.7, 110.93 APE8-dihe-out -50.41, -28.65 APE8-rot-na 335.18 APE67-dihe-in -73.88, -5.16 -55.74, -23.35 APE12-dist-na 19.89 APE11-dist-na 21.192 APE10-dist-na 19.934 APE9-dist-out 11.887 V561M None None XRAY 1.957 0.201 0.254 A 310 294 13 0 0 0 [[478, 756]] 1.0 5am7 TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5AM7B P11362 458 762 822.0 38O:1000 Type1 Inactive DFGin 5.351 13.056 BLAplus -118.51, 161.73 60.87, 31.35 -81.93, -17.68 51.44, 85.63 -98.47, 10.33 in-in in 7.879 Saltbr-in 3.092 HRD-in -70.81, -53.93 79.14, -12.6 in-out-out SNCioo out-out ActLoopNT-out 8.493 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.26, 167.43 APE9-dihe-in -92.91, 111.75 APE8-dihe-out -51.15, -27.96 APE8-rot-na 332.74 APE67-dihe-in -72.49, -4.42 -56.51, -22.72 APE12-dist-na 19.29 APE11-dist-na 21.059 APE10-dist-na 19.935 APE9-dist-out 11.772 V561M None None XRAY 1.957 0.201 0.254 B 310 287 18 0 0 5 [[478, 756]] 1.0 5am7 TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5AM6A P11362 458 765 822.0 38O:61766 Type1 Inactive DFGin 5.201 13.27 BLAplus -112.58, 159.52 61.38, 32.49 -78.96, -18.15 54.05, 84.03 -102.14, 12.3 in-in in 7.715 Saltbr-in 3.252 HRD-in -73.83, -55.77 84.43, -16.37 in-out-out SNCioo out-out ActLoopNT-out 8.728 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.68, 158.35 APE9-dihe-in -101.09, 116.06 APE8-dihe-out -55.18, -24.78 APE8-rot-na 339.12 APE67-dihe-in -70.49, -7.18 -57.16, -24.6 APE12-dist-na 19.76 APE11-dist-na 21.181 APE10-dist-na 19.861 APE9-dist-out 11.765 None None None XRAY 1.96 0.216 0.252 A 310 294 14 0 0 0 [[478, 756]] 1.0 5am6 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5AM6B P11362 458 762 822.0 38O:61763 Type1 Inactive DFGin 5.279 13.04 BLAplus -109.26, 159.81 58.35, 42.16 -91.18, -11.81 51.78, 82.49 -107.62, 15.27 in-in in 7.645 Saltbr-in 3.495 HRD-in -73.63, -54.03 80.88, -21.94 in-out-out SNCioo out-out ActLoopNT-out 8.615 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.73, 157.38 APE9-dihe-in -92.88, 109.99 APE8-dihe-out -51.36, -29.92 APE8-rot-na 334.27 APE67-dihe-in -70.82, -6.38 -56.34, -19.57 APE12-dist-na 999.0 APE11-dist-na 21.131 APE10-dist-na 19.744 APE9-dist-out 11.636 None None None XRAY 1.96 0.216 0.252 B 310 280 25 0 0 13 [[478, 756]] 1.0 5am6 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5A46A P11362 464 766 822.0 38O:1769 Type1 Inactive DFGin 5.213 13.149 BLAplus -118.77, 162.9 58.04, 28.78 -73.18, -26.4 58.45, 90.15 -96.03, 5.5 in-in in 7.513 Saltbr-in 3.005 HRD-in -57.82, -48.72 70.95, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.281 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.0, 143.36 APE9-dihe-in -88.58, 110.07 APE8-dihe-out -58.5, -16.77 APE8-rot-na 337.71 APE67-dihe-in -76.67, -10.73 -63.67, -15.99 APE12-dist-na 20.033 APE11-dist-na 21.324 APE10-dist-na 19.432 APE9-dist-out 12.089 None None None XRAY 2.63 0.182 0.246 A 386 290 13 0 0 3 [[478, 756]] 1.0 5a46 TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5A46B P11362 458 766 822.0 38O:1767 Type1 Inactive DFGin 5.33 12.787 BLAplus -120.14, 161.93 66.72, 19.6 -75.13, -22.14 56.34, 83.44 -97.38, -0.25 in-in in 7.593 Saltbr-in 2.799 HRD-in -68.23, -43.1 73.28, -14.2 in-out-out SNCioo out-out ActLoopNT-out 7.98 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -119.49, 150.14 APE9-dihe-in -90.22, 111.65 APE8-dihe-out -53.72, -24.65 APE8-rot-na 331.17 APE67-dihe-in -66.01, -7.4 -51.07, -30.75 APE12-dist-na 20.292 APE11-dist-na 21.271 APE10-dist-na 19.907 APE9-dist-out 11.879 None None None XRAY 2.63 0.182 0.246 B 386 298 11 0 0 0 [[478, 756]] 1.0 5a46 TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR4 FGFR4_HUMAN 4TYIA P22455 447 750 802.0 38O:60801 Type1 Inactive DFGin 5.017 12.757 BLAplus -124.41, 161.93 65.25, 9.26 -54.13, -39.53 65.77, 95.11 -82.78, -10.75 in-out in 7.441 Saltbr-out 5.518 HRD-out -72.43, 150.77 -73.64, -70.77 out-out-out SNCooo out-out ActLoopNT-out 8.032 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.18 APE8-dihe-in -82.6, 72.32 APE8-rot-na 33.83 APE67-dihe-in -58.23, -33.51 -75.34, -45.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.293 None None None XRAY 3.4 0.281 0.34 A 311 276 28 0 0 14 [[467, 745]] 1.0 4tyi TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4

Ligand: 38O (Dovitinib)

Total number of chains: 14
Active chains: 0
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 7 50.0% 5A46B
DFGin None 4 28.6% 7QQ6B
None None 2 14.3% 5OWQB
DFGin BLAminus 1 7.1% 7AKGA

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK STK17B ST17B_HUMAN 7AKGA O94768 25 309 372.0 38O:60406 Type1 Inactive DFGin 5.926 14.467 BLAminus -130.72, 166.63 65.44, 83.59 -95.88, 22.94 288.63, 83.5 -68.92, -24.29 in-in in 9.846 Saltbr-in 2.802 HRD-in -68.61, -50.56 69.3, 6.9 in-in-out SNCiio in-out ActLoopNT-in 2.98 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -106.87, 75.89 APE9-dihe-na -112.61, -152.27 APE8-dihe-in -87.24, 116.8 APE8-rot-in 316.03 APE67-dihe-in -74.45, -15.03 -47.64, -40.28 APE12-dist-in 7.984 APE11-dist-in 12.31 APE10-dist-out 10.545 APE9-dist-out 6.752 None None None XRAY 2.08 0.187 0.219 A 327 285 0 0 0 0 [[32, 293]] 1.0 7akg Homo sapiens CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6A Q9P2K8 584 1004 1649.0 38O:1701 Type1 Inactive DFGin 4.545 13.832 None -64.42, 179.79 -78.36, -177.52 -104.81, 135.74 11.85, 74.61 -87.56, 999.0 out-out out 10.404 Saltbr-out 7.228 HRD-in -78.55, -45.81 67.95, -11.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -139.37, 156.89 APE9-dihe-na 68.88, -136.49 APE8-dihe-out -63.0, -22.3 APE8-rot-out 54.98 APE67-dihe-in -64.33, -22.31 -64.88, -30.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.309 D848N None None XRAY 2.8 0.213 0.258 A 320 269 26 0 0 20 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6B Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.743 14.437 None -62.22, 177.25 -71.17, -177.31 -113.77, 112.84 16.57, 83.07 -117.04, 75.83 out-out out 10.63 Saltbr-out 6.773 HRD-in -73.84, -58.14 68.49, 11.03 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -145.51, 135.89 APE9-dihe-na 67.14, -114.96 APE8-dihe-out -68.69, -35.73 APE8-rot-out 40.19 APE67-dihe-in -61.7, -18.1 -60.4, -26.4 APE12-dist-out 22.808 APE11-dist-out 18.791 APE10-dist-out 18.981 APE9-dist-out 12.646 D848N None None XRAY 2.8 0.213 0.258 B 320 275 22 0 0 18 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6C Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 5.153 15.331 None -67.88, 178.26 -74.84, 168.69 -62.36, -56.97 309.72, 121.46 57.54, 31.05 out-out out 10.431 Saltbr-out 6.787 HRD-in -71.08, -48.65 67.11, -5.82 out-out-out SNCooo out-out ActLoopNT-out 7.73 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 103.35 APE8-dihe-out -115.25, -20.91 APE8-rot-out 51.72 APE67-dihe-in -84.71, -19.81 -111.62, 33.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.792 D848N None None XRAY 2.8 0.213 0.258 C 320 267 30 0 0 29 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6D Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.793 14.782 None -71.0, 172.41 -73.73, 163.04 -66.19, -82.98 327.33, 91.13 74.54, 67.6 out-out out 11.102 Saltbr-out 6.778 HRD-in -68.97, -46.58 79.03, -46.68 out-out-none SNCoon out-none ActLoopNT-out 6.505 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.25, -17.58 999.0, -55.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.8 0.213 0.258 D 320 260 37 0 0 29 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.1e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
STE STK10 STK10_HUMAN 5OWQA O94804 30 317 968.0 38O:600 Type1 Inactive None 999.0 999.0 None -110.03, 168.4 44.48, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 10.669 Saltbr-none 999.0 HRD-in -81.59, -60.25 72.43, 10.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -97.79, -7.31 999.0, 33.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.265 0.305 A 302 255 33 0 0 20 [[36, 294]] 1.0 5owq Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 5OWQB O94804 32 317 968.0 38O:600 Type1 Inactive None 999.0 999.0 None -111.67, 174.73 56.37, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 10.674 Saltbr-out 5.294 HRD-in -80.32, -59.59 72.13, 11.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -98.8, -4.63 999.0, 29.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.265 0.305 B 302 254 32 0 0 20 [[36, 294]] 1.0 5owq Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
TYR FGFR1 FGFR1_HUMAN 5AM7A P11362 458 764 822.0 38O:1000 Type1 Inactive DFGin 5.322 13.404 BLAplus -119.96, 160.03 61.93, 31.32 -78.06, -16.68 51.95, 91.0 -102.88, 8.06 in-in in 7.784 Saltbr-in 2.821 HRD-in -72.13, -53.65 81.66, -13.87 in-out-out SNCioo out-out ActLoopNT-out 8.844 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.07, 161.69 APE9-dihe-in -97.7, 110.93 APE8-dihe-out -50.41, -28.65 APE8-rot-na 335.18 APE67-dihe-in -73.88, -5.16 -55.74, -23.35 APE12-dist-na 19.89 APE11-dist-na 21.192 APE10-dist-na 19.934 APE9-dist-out 11.887 V561M None None XRAY 1.957 0.201 0.254 A 310 294 13 0 0 0 [[478, 756]] 1.0 5am7 Homo sapiens TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5AM7B P11362 458 762 822.0 38O:1000 Type1 Inactive DFGin 5.351 13.056 BLAplus -118.51, 161.73 60.87, 31.35 -81.93, -17.68 51.44, 85.63 -98.47, 10.33 in-in in 7.879 Saltbr-in 3.092 HRD-in -70.81, -53.93 79.14, -12.6 in-out-out SNCioo out-out ActLoopNT-out 8.493 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.26, 167.43 APE9-dihe-in -92.91, 111.75 APE8-dihe-out -51.15, -27.96 APE8-rot-na 332.74 APE67-dihe-in -72.49, -4.42 -56.51, -22.72 APE12-dist-na 19.29 APE11-dist-na 21.059 APE10-dist-na 19.935 APE9-dist-out 11.772 V561M None None XRAY 1.957 0.201 0.254 B 310 287 18 0 0 5 [[478, 756]] 1.0 5am7 Homo sapiens TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5AM6A P11362 458 765 822.0 38O:61766 Type1 Inactive DFGin 5.201 13.27 BLAplus -112.58, 159.52 61.38, 32.49 -78.96, -18.15 54.05, 84.03 -102.14, 12.3 in-in in 7.715 Saltbr-in 3.252 HRD-in -73.83, -55.77 84.43, -16.37 in-out-out SNCioo out-out ActLoopNT-out 8.728 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.68, 158.35 APE9-dihe-in -101.09, 116.06 APE8-dihe-out -55.18, -24.78 APE8-rot-na 339.12 APE67-dihe-in -70.49, -7.18 -57.16, -24.6 APE12-dist-na 19.76 APE11-dist-na 21.181 APE10-dist-na 19.861 APE9-dist-out 11.765 None None None XRAY 1.96 0.216 0.252 A 310 294 14 0 0 0 [[478, 756]] 1.0 5am6 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5AM6B P11362 458 762 822.0 38O:61763 Type1 Inactive DFGin 5.279 13.04 BLAplus -109.26, 159.81 58.35, 42.16 -91.18, -11.81 51.78, 82.49 -107.62, 15.27 in-in in 7.645 Saltbr-in 3.495 HRD-in -73.63, -54.03 80.88, -21.94 in-out-out SNCioo out-out ActLoopNT-out 8.615 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.73, 157.38 APE9-dihe-in -92.88, 109.99 APE8-dihe-out -51.36, -29.92 APE8-rot-na 334.27 APE67-dihe-in -70.82, -6.38 -56.34, -19.57 APE12-dist-na 999.0 APE11-dist-na 21.131 APE10-dist-na 19.744 APE9-dist-out 11.636 None None None XRAY 1.96 0.216 0.252 B 310 280 25 0 0 13 [[478, 756]] 1.0 5am6 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5A46A P11362 464 766 822.0 38O:1769 Type1 Inactive DFGin 5.213 13.149 BLAplus -118.77, 162.9 58.04, 28.78 -73.18, -26.4 58.45, 90.15 -96.03, 5.5 in-in in 7.513 Saltbr-in 3.005 HRD-in -57.82, -48.72 70.95, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.281 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.0, 143.36 APE9-dihe-in -88.58, 110.07 APE8-dihe-out -58.5, -16.77 APE8-rot-na 337.71 APE67-dihe-in -76.67, -10.73 -63.67, -15.99 APE12-dist-na 20.033 APE11-dist-na 21.324 APE10-dist-na 19.432 APE9-dist-out 12.089 None None None XRAY 2.63 0.182 0.246 A 386 290 13 0 0 3 [[478, 756]] 1.0 5a46 Homo sapiens TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5A46B P11362 458 766 822.0 38O:1767 Type1 Inactive DFGin 5.33 12.787 BLAplus -120.14, 161.93 66.72, 19.6 -75.13, -22.14 56.34, 83.44 -97.38, -0.25 in-in in 7.593 Saltbr-in 2.799 HRD-in -68.23, -43.1 73.28, -14.2 in-out-out SNCioo out-out ActLoopNT-out 7.98 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -119.49, 150.14 APE9-dihe-in -90.22, 111.65 APE8-dihe-out -53.72, -24.65 APE8-rot-na 331.17 APE67-dihe-in -66.01, -7.4 -51.07, -30.75 APE12-dist-na 20.292 APE11-dist-na 21.271 APE10-dist-na 19.907 APE9-dist-out 11.879 None None None XRAY 2.63 0.182 0.246 B 386 298 11 0 0 0 [[478, 756]] 1.0 5a46 Homo sapiens TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR4 FGFR4_HUMAN 4TYIA P22455 447 750 802.0 38O:60801 Type1 Inactive DFGin 5.017 12.757 BLAplus -124.41, 161.93 65.25, 9.26 -54.13, -39.53 65.77, 95.11 -82.78, -10.75 in-out in 7.441 Saltbr-out 5.518 HRD-out -72.43, 150.77 -73.64, -70.77 out-out-out SNCooo out-out ActLoopNT-out 8.032 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.18 APE8-dihe-in -82.6, 72.32 APE8-rot-na 33.83 APE67-dihe-in -58.23, -33.51 -75.34, -45.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.293 None None None XRAY 3.4 0.281 0.34 A 311 276 28 0 0 14 [[467, 745]] 1.0 4tyi Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4

Ligand: 38O (Dovitinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name