Ligand: 1N1 (Dasatinib)

Total number of chains: 23
Active chains: 2
Total number of genes: 11
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 26.1% 4QMSA
DFGin BLBplus 4 17.4% 5H2UA
DFGinter BABtrans 4 17.4% 3SXRA
DFGinter None 4 17.4% 4XEYA
DFGin BLBminus 2 8.7% 5I9YA
DFGin BLAplus 1 4.3% 3K54A
DFGout None 1 4.3% 5BVWA
None None 1 4.3% 3LFAA

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK14 MK14_HUMAN 3LFAA Q16539 4 353 360.0 1N1:361 Type1 Inactive None 999.0 999.0 None -119.32, 169.35 -154.54, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2412 Saltbr-in 2.7349 HRD-in -67.55, -57.07 85.83, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.05 APE8-dihe-out -85.63, -3.59 APE8-rot-in 346.34 APE67-dihe-in -59.81, -27.96 -94.61, -12.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8947 None None None XRAY 2.1 0.204 0.254 A 360.0 333.0 17 25 10 15 [[24, 308]] 1.0 3lfa CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
OTHER PKMYT1 PMYT1_HUMAN 5VCVA Q99640 75 361 499.0 1N1:60404 Type1 Inactive DFGin 6.1731 14.4679 BLAminus -133.17, -164.16 53.7, 76.36 -96.77, 22.58 298.04, 107.44 -64.77, -25.22 in-in in 8.9178 Saltbr-in 2.826 HRD-in -73.66, -44.65 68.1, -0.34 in-in-out SNCiio in-out ActLoopNT-in 2.8927 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -65.91, 159.0 APE9-dihe-na -91.66, -157.73 APE8-dihe-in -52.29, 123.12 APE8-rot-na 188.83 APE67-dihe-in -60.44, -30.04 -60.97, -24.44 APE12-dist-in 7.9448 APE11-dist-out 6.4495 APE10-dist-out 9.0797 APE9-dist-in 3.1786 None TPO260 TPO260 XRAY 1.92 0.157 0.197 A 311.0 287.0 0 27 27 0 [[110, 359]] 1.0 5vcv OTHER_PKMYT1_HUMAN STE 9.9e-39 139.4 1.0 255.0 255.0 250 251 252 254 256 139 157 161 230 232 231 233.0 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
STE STK10 STK10_HUMAN 5OWRA O94804 23 317 968.0 1N1:401 Type1 Inactive DFGin 6.4982 16.7221 BLAminus -126.18, 173.2 57.39, 79.01 -91.46, 24.21 286.72, 77.35 -53.02, -57.95 out-out out 10.2052 Saltbr-out 8.1359 HRD-in -70.96, -54.03 67.34, 13.9 out-out-none SNCoon out-none ActLoopNT-out 5.8335 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.94, -27.24 999.0, -15.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.221 0.254 A 302.0 282.0 13 28 21 7 [[36, 294]] 1.0 5owr STE_STK10_HUMAN STE 2e-94 321.6 1.0 257.0 257.0 174 175 176 178 180 65 81 85 154 156 155 157.0 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK24 STK24_HUMAN 4QMSA Q9Y6E0 27 310 443.0 1N1:60401 Type1 Inactive DFGin 7.0296 15.2785 BLAminus -133.65, 170.4 59.12, 88.65 -100.44, 27.96 287.36, 78.03 -60.48, -24.48 in-out in 9.6308 Saltbr-out 4.5468 HRD-in -69.75, -48.6 69.83, 3.91 out-in-in SNCoii in-in ActLoopNT-in 2.7927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.42, 162.17 APE9-dihe-na 128.43, -166.04 APE8-dihe-in -119.95, 120.69 APE8-rot-in 305.76 APE67-dihe-in -58.87, -30.57 -46.04, -47.24 APE12-dist-in 8.2773 APE11-dist-in 10.9536 APE10-dist-in 5.1134 APE9-dist-in 3.3059 None TPO190 TPO190 XRAY 1.883 0.169 0.214 A 310.0 284.0 0 28 28 0 [[36, 286]] 1.0 4qms STE_STK24_HUMAN STE 3.9e-100 340.4 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TYR ABL1 ABL1_HUMAN 7N9GB P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Active DFGin 6.7541 13.4449 BLAminus -122.97, -168.58 58.54, 84.79 -109.7, 15.38 305.77, 104.92 -56.72, -36.19 in-in in 7.8072 Saltbr-in 2.716 HRD-in -94.83, -54.73 76.06, 6.03 in-in-in SNCiii in-in ActLoopNT-in 3.0408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.97, 124.86 APE9-dihe-in -118.42, 152.72 APE8-dihe-in -70.17, 95.62 APE8-rot-na 28.18 APE67-dihe-in -73.36, -13.19 -53.92, -45.07 APE12-dist-na 14.9514 APE11-dist-na 10.1213 APE10-dist-na 12.2789 APE9-dist-in 7.1369 None None None XRAY 2.2 0.219 0.251 B 271.0 264.0 2 29 29 0 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2GQGA P00519 229 500 1130.0 1N1:60501 Type1 Inactive DFGin 6.6367 14.0391 BLAminus -125.87, -162.48 50.1, 80.24 -101.91, 13.59 304.08, 105.04 -55.58, -28.07 in-in in 8.2064 Saltbr-in 3.3367 HRD-in -94.17, -46.19 69.1, 8.59 in-in-out SNCiio in-out ActLoopNT-in 3.0889 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.45, -178.77 APE9-dihe-in -144.75, 146.99 APE8-dihe-in -51.41, 101.22 APE8-rot-na 30.18 APE67-dihe-in -72.33, -8.18 -47.68, -48.27 APE12-dist-na 13.8069 APE11-dist-na 10.1551 APE10-dist-na 13.162 APE9-dist-in 7.0168 None PTR393 PTR393 XRAY 2.4 0.208 0.273 A 278.0 272.0 0 29 29 0 [[242, 495]] 1.0 2gqg TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2GQGB P00519 229 499 1130.0 1N1:60502 Type1.5_Back Active DFGin 6.7246 13.4066 BLAminus -132.96, -163.46 57.81, 75.2 -98.78, 6.6 302.62, 104.4 -52.45, -32.74 in-in in 8.0337 Saltbr-in 2.8987 HRD-in -101.91, -48.31 65.85, 10.15 in-in-in SNCiii in-in ActLoopNT-in 2.9585 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.98, 171.69 APE9-dihe-in -137.71, 138.65 APE8-dihe-in -58.61, 114.78 APE8-rot-na 30.65 APE67-dihe-in -71.5, -8.45 -53.53, -44.9 APE12-dist-na 11.2577 APE11-dist-na 7.468 APE10-dist-na 11.6413 APE9-dist-in 6.2756 None PTR393 PTR393 XRAY 2.4 0.208 0.273 B 278.0 271.0 0 29 29 0 [[242, 495]] 1.0 2gqg TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYB P00519 122 504 1130.0 1N1:60601 Type1 Inactive DFGinter 10.0007 8.0224 BABtrans -71.04, 121.63 -84.68, 7.52 -91.76, 101.26 207.86, 90.35 143.13, -1.76 in-out in 8.918 Saltbr-out 8.6427 HRD-out -101.25, 126.15 -79.9, -27.01 out-out-in SNCooi out-in ActLoopNT-out 5.4222 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.63, 133.07 APE9-dihe-in -116.3, 152.74 APE8-dihe-in -66.44, 99.47 APE8-rot-na 21.89 APE67-dihe-in -71.31, -17.26 -44.98, -48.3 APE12-dist-na 18.5596 APE11-dist-na 13.9233 APE10-dist-na 16.5485 APE9-dist-in 6.4285 None None None XRAY 2.891 0.232 0.259 B 408.0 359.0 9 29 29 0 [[242, 495]] 1.0 4xey TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GA P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.4212 8.1868 None -69.43, 136.44 -123.08, 27.78 -75.4, -30.96 178.85, 77.99 -98.31, 50.2 in-out in 8.8784 Saltbr-out 9.7861 HRD-out -92.88, 142.81 -110.01, 0.88 out-out-none SNCoon out-none ActLoopNT-out 5.5443 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.84 APE8-dihe-in -72.01, 95.09 APE8-rot-na 30.25 APE67-dihe-in -73.75, -10.66 -54.08, -44.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.8503 None None None XRAY 2.2 0.219 0.251 A 271.0 250.0 16 29 16 13 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GC P00519 234 499 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.016 7.7618 None -68.53, 140.81 -120.26, 3.31 -57.57, -42.4 182.82, 108.58 -86.96, 40.71 in-none in 9.4392 Saltbr-none 999.0 HRD-out -106.92, 134.12 -80.26, -30.58 none-out-none SNCnon out-none ActLoopNT-out 5.4779 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.82 APE8-dihe-in -65.53, 99.76 APE8-rot-na 23.57 APE67-dihe-in -73.61, -20.46 -60.17, -42.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.8914 None None None XRAY 2.2 0.219 0.251 C 271.0 233.0 33 29 24 5 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYA P00519 231 503 1130.0 1N1:60601 Type1 Inactive DFGinter 9.993 7.9273 None -70.89, 123.51 -90.91, 18.27 -87.3, -11.95 199.48, 77.0 -96.54, 13.69 in-out in 8.9479 Saltbr-out 8.6903 HRD-out -101.8, 125.8 -78.66, -28.68 out-out-in SNCooi out-in ActLoopNT-out 5.3933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.59, 140.17 APE9-dihe-in -145.27, 142.92 APE8-dihe-in -62.13, 98.18 APE8-rot-na 23.13 APE67-dihe-in -73.29, -19.48 -49.65, -41.78 APE12-dist-na 18.7302 APE11-dist-na 14.1077 APE10-dist-na 16.5419 APE9-dist-in 6.5879 None None None XRAY 2.891 0.232 0.259 A 408.0 269.0 4 29 29 0 [[242, 495]] 1.0 4xey TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR BMX BMX_HUMAN 3SXRA P51813 411 671 675.0 1N1:60001 Type1 Inactive DFGinter 7.8824 8.1671 BABtrans -93.57, 121.18 -103.19, -9.04 -51.22, 114.45 184.77, 74.21 62.74, 18.94 out-out out 10.805 Saltbr-out 7.5586 HRD-out -99.0, 124.02 -80.22, -7.53 out-in-in SNCoii in-in ActLoopNT-in 2.8353 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.14, 119.04 APE9-dihe-in -94.0, 160.01 APE8-dihe-in -48.96, 127.48 APE8-rot-na 331.52 APE67-dihe-in -68.66, -11.59 -65.07, -24.25 APE12-dist-na 10.0286 APE11-dist-na 7.5492 APE10-dist-na 12.0421 APE9-dist-in 5.1857 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 A 268.0 257.0 4 29 29 0 [[417, 668]] 1.0 3sxr TYR_BMX_HUMAN TYR 3.1e-93 317.8 1.0 260.0 260.0 553 554 555 557 559 445 460 464 533 535 534 536.0 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXRB P51813 411 671 675.0 1N1:60002 Type1 Inactive DFGinter 7.7085 8.2724 BABtrans -92.79, 121.27 -96.68, -12.13 -49.05, 115.54 186.98, 71.37 61.78, 19.24 out-out out 10.8028 Saltbr-out 8.0973 HRD-out -100.92, 124.05 -80.64, -7.7 out-in-in SNCoii in-in ActLoopNT-in 2.8449 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.81, 125.57 APE9-dihe-in -101.37, 158.16 APE8-dihe-in -49.48, 128.1 APE8-rot-na 332.21 APE67-dihe-in -66.79, -11.14 -62.63, -27.73 APE12-dist-na 9.9457 APE11-dist-na 7.4465 APE10-dist-na 11.9437 APE9-dist-in 5.1904 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 B 268.0 255.0 6 29 29 0 [[417, 668]] 1.0 3sxr TYR_BMX_HUMAN TYR 3.1e-93 317.8 1.0 260.0 260.0 553 554 555 557 559 445 460 464 533 535 534 536.0 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BTK BTK_HUMAN 3K54A Q06187 392 658 659.0 1N1:1 Type1 Inactive DFGin 4.6816 13.9981 BLAplus -132.68, -179.17 50.27, 30.98 -93.41, -0.42 58.12, 86.77 -82.65, 999.0 in-out in 8.7866 Saltbr-out 3.7709 HRD-in -69.54, -47.61 72.38, -12.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.06 APE8-dihe-in -84.11, 69.82 APE8-rot-na 29.89 APE67-dihe-in -70.22, -9.36 -47.67, -47.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1055 Y551E None None XRAY 1.94 0.202 0.258 A 283.0 243.0 24 29 12 17 [[402, 653]] 1.0 3k54 TYR_BTK_HUMAN TYR 1.6e-92 315.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 3OCTA Q06187 394 656 659.0 1N1:663 Type1 Inactive DFGinter 9.5513 8.0475 BABtrans -83.49, 139.01 -103.95, 15.92 -87.02, 132.92 181.28, 97.3 77.87, 26.97 in-out in 9.203 Saltbr-out 7.7453 HRD-in -70.28, -48.13 67.57, -13.36 out-out-none SNCoon out-none ActLoopNT-out 5.3805 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.42 APE8-dihe-in -60.66, 106.57 APE8-rot-na 28.18 APE67-dihe-in -77.0, -13.84 -55.35, -41.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7096 V555R None None XRAY 1.95 0.199 0.251 A 265.0 244.0 19 29 15 14 [[402, 653]] 1.0 3oct TYR_BTK_HUMAN TYR 2.3e-93 318.2 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR DDR1 DDR1_HUMAN 6BSDA Q08345 604 912 913.0 1N1:60901 Type1 Inactive DFGinter 9.9484 9.844 None -87.87, 155.34 -64.16, -24.42 174.69, 170.82 68.3, 89.44 55.93, 999.0 in-in in 8.3705 Saltbr-in 2.7354 HRD-in -61.68, -56.93 83.98, -4.33 in-out-in SNCioi out-in ActLoopNT-out 19.8476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.74, 115.57 APE9-dihe-in -116.16, 127.65 APE8-dihe-in -81.76, 68.68 APE8-rot-na 34.21 APE67-dihe-in -66.93, -20.25 -61.43, -30.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1458 None None None XRAY 2.606 0.186 0.255 A 351.0 278.0 31 30 28 2 [[610, 907]] 1.0 6bsd TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1.0 260.0 260.0 783 784 785 787 789 655 672 676 763 765 764 766.0 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 5BVWA Q08345 604 911 913.0 1N1:1009 Type1 Inactive DFGout 14.538 10.296 None -113.16, 175.58 -102.37, -21.68 40.34, 118.5 221.24, 85.03 -134.54, 999.0 in-in in 8.3337 Saltbr-in 2.775 HRD-in -77.35, -46.96 73.51, -12.24 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.96, 123.56 APE9-dihe-in -122.26, 123.59 APE8-dihe-in -77.84, 65.49 APE8-rot-na 31.29 APE67-dihe-in -69.31, -14.79 -54.53, -34.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.409 None None None XRAY 1.94 0.186 0.234 A 324.0 274.0 34 30 26 4 [[610, 907]] 1.0 5bvw TYR_DDR1_HUMAN TYR 1.7e-92 315.4 1.0 260.0 260.0 783 784 785 787 789 655 672 676 763 765 764 766.0 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EPHA2 EPHA2_HUMAN 5I9YA P29317 600 896 976.0 1N1:1001 Type1 Inactive DFGin 6.2223 14.973 BLBminus -129.12, 177.86 73.14, 77.74 -114.09, 153.37 295.9, 102.04 147.64, -171.81 in-in in 8.2568 Saltbr-in 2.7741 HRD-in -75.07, -47.16 76.83, -16.24 in-out-none SNCion out-none ActLoopNT-out 10.4586 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 139.34 APE8-rot-na 36.16 APE67-dihe-in -79.28, -3.2 -53.92, -45.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.228 0.164 0.179 A 306.0 287.0 10 31 24 7 [[613, 873]] 1.0 5i9y TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHB4 EPHB4_HUMAN 6FNMA P54760 608 889 987.0 1N1:1001 Type1 Inactive DFGin 5.9609 15.7692 BLBminus -128.55, -169.2 67.78, 75.65 -110.02, 138.75 293.26, 98.41 179.12, 146.16 in-in in 8.3255 Saltbr-in 3.1793 HRD-in -76.03, -51.54 81.54, -15.45 in-out-in SNCioi out-in ActLoopNT-out 10.0097 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 157.69 APE9-dihe-in -64.87, 128.21 APE8-dihe-in -78.96, 90.14 APE8-rot-na 30.03 APE67-dihe-in -61.19, -22.58 -57.17, -48.0 APE12-dist-na 999.0 APE11-dist-na 11.3678 APE10-dist-na 15.0342 APE9-dist-in 6.5764 Y774E,A803V,V870I None None XRAY 1.157 0.184 0.195 A 297.0 270.0 12 33 21 12 [[615, 876]] 1.0 6fnm TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR PTK6 PTK6_HUMAN 5H2UA Q13882 185 446 451.0 1N1:60501 Type1 Inactive DFGin 5.9983 13.4628 BLBplus -115.66, 172.2 65.44, 13.7 -58.08, 130.19 47.49, 85.54 66.94, -1.55 out-out out 14.1683 Saltbr-out 16.091 HRD-in -72.57, -54.48 85.53, -13.44 out-out-out SNCooo out-out ActLoopNT-out 7.2608 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out 72.03, 33.67 APE9-dihe-out -55.65, -32.62 APE8-dihe-out -63.18, -18.16 APE8-rot-na 340.69 APE67-dihe-in -82.41, -18.93 -56.57, -27.65 APE12-dist-na 16.3439 APE11-dist-na 20.6081 APE10-dist-na 18.2629 APE9-dist-out 11.0621 C433T None None XRAY 2.24 0.208 0.26 A 267.0 261.0 1 28 28 0 [[191, 443]] 1.0 5h2u TYR_PTK6_HUMAN TYR 9.8e-89 303.0 2.0 260.0 259.0 329 330 331 333 335 219 235 239 309 311 310 312.0 369 357 352 351 350 349 348 347 346 265 Protein-tyrosine kinase 6
TYR PTK6 PTK6_HUMAN 5H2UB Q13882 185 446 451.0 1N1:60501 Type1 Inactive DFGin 6.0808 13.3427 BLBplus -112.62, 168.56 69.96, 13.64 -58.15, 126.09 44.9, 88.52 70.74, 0.77 out-out out 14.3036 Saltbr-out 15.9567 HRD-in -65.56, -52.22 84.8, -15.83 out-out-out SNCooo out-out ActLoopNT-out 7.0671 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out 67.1, 31.04 APE9-dihe-out -51.48, -32.62 APE8-dihe-out -56.92, -21.84 APE8-rot-na 331.92 APE67-dihe-in -82.05, -11.15 -61.67, -25.37 APE12-dist-na 16.2609 APE11-dist-na 20.2262 APE10-dist-na 17.9045 APE9-dist-out 11.0552 C433T None None XRAY 2.24 0.208 0.26 B 267.0 261.0 1 28 28 0 [[191, 443]] 1.0 5h2u TYR_PTK6_HUMAN TYR 9.8e-89 303.0 2.0 260.0 259.0 329 330 331 333 335 219 235 239 309 311 310 312.0 369 357 352 351 350 349 348 347 346 265 Protein-tyrosine kinase 6
TYR PTK6 PTK6_HUMAN 5H2UC Q13882 185 446 451.0 1N1:60501 Type1 Inactive DFGin 5.9677 13.6341 BLBplus -101.49, 165.12 71.33, 11.9 -56.7, 126.68 46.28, 85.99 72.45, -1.55 out-out out 14.2504 Saltbr-out 15.3617 HRD-in -69.3, -53.89 83.99, -9.53 out-out-out SNCooo out-out ActLoopNT-out 7.1583 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out 66.45, 29.68 APE9-dihe-out -47.22, -37.04 APE8-dihe-out -58.56, -24.03 APE8-rot-na 334.48 APE67-dihe-in -84.14, -9.31 -53.24, -25.76 APE12-dist-na 16.3889 APE11-dist-na 20.3117 APE10-dist-na 17.9592 APE9-dist-out 11.0174 C433T None None XRAY 2.24 0.208 0.26 C 267.0 261.0 1 28 28 0 [[191, 443]] 1.0 5h2u TYR_PTK6_HUMAN TYR 9.8e-89 303.0 2.0 260.0 259.0 329 330 331 333 335 219 235 239 309 311 310 312.0 369 357 352 351 350 349 348 347 346 265 Protein-tyrosine kinase 6
TYR PTK6 PTK6_HUMAN 5H2UD Q13882 185 446 451.0 1N1:60504 Type1 Inactive DFGin 6.1814 13.2695 BLBplus -112.73, 164.13 73.65, 11.67 -56.94, 123.73 42.41, 88.79 73.17, 2.96 out-out out 14.0107 Saltbr-out 15.9929 HRD-in -70.19, -55.11 88.71, -18.22 out-out-out SNCooo out-out ActLoopNT-out 7.1947 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out 72.07, 30.74 APE9-dihe-out -48.72, -36.76 APE8-dihe-out -61.03, -20.74 APE8-rot-na 334.99 APE67-dihe-in -84.77, -13.01 -55.36, -26.11 APE12-dist-na 16.3004 APE11-dist-na 20.346 APE10-dist-na 18.0251 APE9-dist-out 11.0324 C433T None None XRAY 2.24 0.208 0.26 D 267.0 261.0 1 28 28 0 [[191, 443]] 1.0 5h2u TYR_PTK6_HUMAN TYR 9.8e-89 303.0 2.0 260.0 259.0 329 330 331 333 335 219 235 239 309 311 310 312.0 369 357 352 351 350 349 348 347 346 265 Protein-tyrosine kinase 6

Ligand: 1N1 (Dasatinib)

Total number of chains: 35
Active chains: 3
Total number of genes: 16
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 13 37.1% 4QMSA
DFGinter BABtrans 6 17.1% 3SXRA
DFGin BLBplus 4 11.4% 5H2UA
DFGinter None 4 11.4% 4XEYA
DFGout None 3 8.6% 3OHTA
DFGin BLBminus 2 5.7% 5I9YA
DFGin BLAplus 1 2.9% 3K54A
DFGin None 1 2.9% 2Y6OA
None None 1 2.9% 3LFAA

Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3QLGA P00523 258 533 533.0 1N1:601 Type1.5_Back Inactive DFGin 6.5502 13.8381 BLAminus -128.97, 169.0 62.45, 93.12 -106.99, 6.4 306.69, 101.34 -122.4, 999.0 in-in in 8.7224 Saltbr-in 2.9531 HRD-in -90.7, -55.87 92.28, -19.25 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.4 APE8-dihe-in -85.59, 52.69 APE8-rot-na 6.03 APE67-dihe-in -68.2, -8.8 -50.34, -41.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.1548 L317I None None XRAY 2.75 0.203 0.269 A 286.0 259.0 17 29 12 17 [[267, 518]] 1.0 3qlg Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3QLGB P00523 256 533 533.0 1N1:601 Type1.5_Back Inactive DFGin 6.2634 13.1722 BLAminus -132.53, 169.92 55.67, 96.64 -114.48, 23.35 323.76, 73.27 -64.65, -16.14 in-in in 8.523 Saltbr-in 2.7156 HRD-in -89.78, -56.21 92.27, -19.49 in-in-out SNCiio in-out ActLoopNT-in 3.1877 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.14 APE8-dihe-in -84.28, 53.37 APE8-rot-na 5.94 APE67-dihe-in -68.54, -8.95 -50.64, -40.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0573 L317I None None XRAY 2.75 0.203 0.269 B 286.0 260.0 18 29 16 13 [[267, 518]] 1.0 3qlg Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3G5DA P00523 257 533 533.0 1N1:1 Type1.5_Back None DFGin 6.7191 14.1749 BLAminus -122.29, -173.62 52.53, 77.9 -96.14, 20.03 300.27, 89.98 -55.15, -32.52 in-in in 8.2259 Saltbr-in 3.4707 HRD-in -89.79, -51.87 81.03, -11.33 in-in-none SNCiin in-none ActLoopNT-in 3.1848 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.62 APE8-dihe-in -62.24, 114.12 APE8-rot-na 23.22 APE67-dihe-in -69.68, -25.09 -60.39, -25.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7563 S345C None None XRAY 2.2 0.207 0.257 A 286.0 256.0 21 29 16 13 [[267, 518]] 1.0 3g5d Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3G5DB P00523 258 533 533.0 1N1:1 Type1.5_Back None DFGin 6.2754 13.5136 BLAminus -124.9, 179.31 57.13, 77.85 -97.54, 21.78 318.72, 94.26 -57.84, -11.35 in-in in 8.332 Saltbr-in 2.9563 HRD-in -82.76, -54.14 84.2, -12.02 in-in-none SNCiin in-none ActLoopNT-in 3.1515 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.98 APE8-dihe-in -55.02, 101.46 APE8-rot-na 16.54 APE67-dihe-in -66.6, -25.87 -58.78, -30.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.0801 S345C None None XRAY 2.2 0.207 0.257 B 286.0 257.0 19 29 16 13 [[267, 518]] 1.0 3g5d Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
CMGC MAPK14 MK14_HUMAN 3LFAA Q16539 4 353 360.0 1N1:361 Type1 Inactive None 999.0 999.0 None -119.32, 169.35 -154.54, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.2412 Saltbr-in 2.7349 HRD-in -67.55, -57.07 85.83, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 157.05 APE8-dihe-out -85.63, -3.59 APE8-rot-in 346.34 APE67-dihe-in -59.81, -27.96 -94.61, -12.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.8947 None None None XRAY 2.1 0.204 0.254 A 360.0 333.0 17 25 10 15 [[24, 308]] 1.0 3lfa Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
OTHER PKMYT1 PMYT1_HUMAN 5VCVA Q99640 75 361 499.0 1N1:60404 Type1 Inactive DFGin 6.1731 14.4679 BLAminus -133.17, -164.16 53.7, 76.36 -96.77, 22.58 298.04, 107.44 -64.77, -25.22 in-in in 8.9178 Saltbr-in 2.826 HRD-in -73.66, -44.65 68.1, -0.34 in-in-out SNCiio in-out ActLoopNT-in 2.8927 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -65.91, 159.0 APE9-dihe-na -91.66, -157.73 APE8-dihe-in -52.29, 123.12 APE8-rot-na 188.83 APE67-dihe-in -60.44, -30.04 -60.97, -24.44 APE12-dist-in 7.9448 APE11-dist-out 6.4495 APE10-dist-out 9.0797 APE9-dist-in 3.1786 None TPO260 TPO260 XRAY 1.92 0.157 0.197 A 311.0 287.0 0 27 27 0 [[110, 359]] 1.0 5vcv Homo sapiens OTHER_PKMYT1_HUMAN STE 9.9e-39 139.4 1.0 255.0 255.0 250 251 252 254 256 139 157 161 230 232 231 233.0 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
STE STK10 STK10_HUMAN 5OWRA O94804 23 317 968.0 1N1:401 Type1 Inactive DFGin 6.4982 16.7221 BLAminus -126.18, 173.2 57.39, 79.01 -91.46, 24.21 286.72, 77.35 -53.02, -57.95 out-out out 10.2052 Saltbr-out 8.1359 HRD-in -70.96, -54.03 67.34, 13.9 out-out-none SNCoon out-none ActLoopNT-out 5.8335 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.94, -27.24 999.0, -15.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.221 0.254 A 302.0 282.0 13 28 21 7 [[36, 294]] 1.0 5owr Homo sapiens STE_STK10_HUMAN STE 2e-94 321.6 1.0 257.0 257.0 174 175 176 178 180 65 81 85 154 156 155 157.0 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK24 STK24_HUMAN 4QMSA Q9Y6E0 27 310 443.0 1N1:60401 Type1 Inactive DFGin 7.0296 15.2785 BLAminus -133.65, 170.4 59.12, 88.65 -100.44, 27.96 287.36, 78.03 -60.48, -24.48 in-out in 9.6308 Saltbr-out 4.5468 HRD-in -69.75, -48.6 69.83, 3.91 out-in-in SNCoii in-in ActLoopNT-in 2.7927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.42, 162.17 APE9-dihe-na 128.43, -166.04 APE8-dihe-in -119.95, 120.69 APE8-rot-in 305.76 APE67-dihe-in -58.87, -30.57 -46.04, -47.24 APE12-dist-in 8.2773 APE11-dist-in 10.9536 APE10-dist-in 5.1134 APE9-dist-in 3.3059 None TPO190 TPO190 XRAY 1.883 0.169 0.214 A 310.0 284.0 0 28 28 0 [[36, 286]] 1.0 4qms Homo sapiens STE_STK24_HUMAN STE 3.9e-100 340.4 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TYR ABL1 ABL1_HUMAN 7N9GB P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Active DFGin 6.7541 13.4449 BLAminus -122.97, -168.58 58.54, 84.79 -109.7, 15.38 305.77, 104.92 -56.72, -36.19 in-in in 7.8072 Saltbr-in 2.716 HRD-in -94.83, -54.73 76.06, 6.03 in-in-in SNCiii in-in ActLoopNT-in 3.0408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.97, 124.86 APE9-dihe-in -118.42, 152.72 APE8-dihe-in -70.17, 95.62 APE8-rot-na 28.18 APE67-dihe-in -73.36, -13.19 -53.92, -45.07 APE12-dist-na 14.9514 APE11-dist-na 10.1213 APE10-dist-na 12.2789 APE9-dist-in 7.1369 None None None XRAY 2.2 0.219 0.251 B 271.0 264.0 2 29 29 0 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2GQGA P00519 229 500 1130.0 1N1:60501 Type1 Inactive DFGin 6.6367 14.0391 BLAminus -125.87, -162.48 50.1, 80.24 -101.91, 13.59 304.08, 105.04 -55.58, -28.07 in-in in 8.2064 Saltbr-in 3.3367 HRD-in -94.17, -46.19 69.1, 8.59 in-in-out SNCiio in-out ActLoopNT-in 3.0889 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.45, -178.77 APE9-dihe-in -144.75, 146.99 APE8-dihe-in -51.41, 101.22 APE8-rot-na 30.18 APE67-dihe-in -72.33, -8.18 -47.68, -48.27 APE12-dist-na 13.8069 APE11-dist-na 10.1551 APE10-dist-na 13.162 APE9-dist-in 7.0168 None PTR393 PTR393 XRAY 2.4 0.208 0.273 A 278.0 272.0 0 29 29 0 [[242, 495]] 1.0 2gqg Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2GQGB P00519 229 499 1130.0 1N1:60502 Type1.5_Back Active DFGin 6.7246 13.4066 BLAminus -132.96, -163.46 57.81, 75.2 -98.78, 6.6 302.62, 104.4 -52.45, -32.74 in-in in 8.0337 Saltbr-in 2.8987 HRD-in -101.91, -48.31 65.85, 10.15 in-in-in SNCiii in-in ActLoopNT-in 2.9585 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.98, 171.69 APE9-dihe-in -137.71, 138.65 APE8-dihe-in -58.61, 114.78 APE8-rot-na 30.65 APE67-dihe-in -71.5, -8.45 -53.53, -44.9 APE12-dist-na 11.2577 APE11-dist-na 7.468 APE10-dist-na 11.6413 APE9-dist-in 6.2756 None PTR393 PTR393 XRAY 2.4 0.208 0.273 B 278.0 271.0 0 29 29 0 [[242, 495]] 1.0 2gqg Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYB P00519 122 504 1130.0 1N1:60601 Type1 Inactive DFGinter 10.0007 8.0224 BABtrans -71.04, 121.63 -84.68, 7.52 -91.76, 101.26 207.86, 90.35 143.13, -1.76 in-out in 8.918 Saltbr-out 8.6427 HRD-out -101.25, 126.15 -79.9, -27.01 out-out-in SNCooi out-in ActLoopNT-out 5.4222 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.63, 133.07 APE9-dihe-in -116.3, 152.74 APE8-dihe-in -66.44, 99.47 APE8-rot-na 21.89 APE67-dihe-in -71.31, -17.26 -44.98, -48.3 APE12-dist-na 18.5596 APE11-dist-na 13.9233 APE10-dist-na 16.5485 APE9-dist-in 6.4285 None None None XRAY 2.891 0.232 0.259 B 408.0 359.0 9 29 29 0 [[242, 495]] 1.0 4xey Homo sapiens TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GA P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.4212 8.1868 None -69.43, 136.44 -123.08, 27.78 -75.4, -30.96 178.85, 77.99 -98.31, 50.2 in-out in 8.8784 Saltbr-out 9.7861 HRD-out -92.88, 142.81 -110.01, 0.88 out-out-none SNCoon out-none ActLoopNT-out 5.5443 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.84 APE8-dihe-in -72.01, 95.09 APE8-rot-na 30.25 APE67-dihe-in -73.75, -10.66 -54.08, -44.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.8503 None None None XRAY 2.2 0.219 0.251 A 271.0 250.0 16 29 16 13 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GC P00519 234 499 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.016 7.7618 None -68.53, 140.81 -120.26, 3.31 -57.57, -42.4 182.82, 108.58 -86.96, 40.71 in-none in 9.4392 Saltbr-none 999.0 HRD-out -106.92, 134.12 -80.26, -30.58 none-out-none SNCnon out-none ActLoopNT-out 5.4779 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.82 APE8-dihe-in -65.53, 99.76 APE8-rot-na 23.57 APE67-dihe-in -73.61, -20.46 -60.17, -42.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.8914 None None None XRAY 2.2 0.219 0.251 C 271.0 233.0 33 29 24 5 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYA P00519 231 503 1130.0 1N1:60601 Type1 Inactive DFGinter 9.993 7.9273 None -70.89, 123.51 -90.91, 18.27 -87.3, -11.95 199.48, 77.0 -96.54, 13.69 in-out in 8.9479 Saltbr-out 8.6903 HRD-out -101.8, 125.8 -78.66, -28.68 out-out-in SNCooi out-in ActLoopNT-out 5.3933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.59, 140.17 APE9-dihe-in -145.27, 142.92 APE8-dihe-in -62.13, 98.18 APE8-rot-na 23.13 APE67-dihe-in -73.29, -19.48 -49.65, -41.78 APE12-dist-na 18.7302 APE11-dist-na 14.1077 APE10-dist-na 16.5419 APE9-dist-in 6.5879 None None None XRAY 2.891 0.232 0.259 A 408.0 269.0 4 29 29 0 [[242, 495]] 1.0 4xey Homo sapiens TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR BMX BMX_HUMAN 3SXRA P51813 411 671 675.0 1N1:60001 Type1 Inactive DFGinter 7.8824 8.1671 BABtrans -93.57, 121.18 -103.19, -9.04 -51.22, 114.45 184.77, 74.21 62.74, 18.94 out-out out 10.805 Saltbr-out 7.5586 HRD-out -99.0, 124.02 -80.22, -7.53 out-in-in SNCoii in-in ActLoopNT-in 2.8353 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.14, 119.04 APE9-dihe-in -94.0, 160.01 APE8-dihe-in -48.96, 127.48 APE8-rot-na 331.52 APE67-dihe-in -68.66, -11.59 -65.07, -24.25 APE12-dist-na 10.0286 APE11-dist-na 7.5492 APE10-dist-na 12.0421 APE9-dist-in 5.1857 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 A 268.0 257.0 4 29 29 0 [[417, 668]] 1.0 3sxr Homo sapiens TYR_BMX_HUMAN TYR 3.1e-93 317.8 1.0 260.0 260.0 553 554 555 557 559 445 460 464 533 535 534 536.0 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXRB P51813 411 671 675.0 1N1:60002 Type1 Inactive DFGinter 7.7085 8.2724 BABtrans -92.79, 121.27 -96.68, -12.13 -49.05, 115.54 186.98, 71.37 61.78, 19.24 out-out out 10.8028 Saltbr-out 8.0973 HRD-out -100.92, 124.05 -80.64, -7.7 out-in-in SNCoii in-in ActLoopNT-in 2.8449 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.81, 125.57 APE9-dihe-in -101.37, 158.16 APE8-dihe-in -49.48, 128.1 APE8-rot-na 332.21 APE67-dihe-in -66.79, -11.14 -62.63, -27.73 APE12-dist-na 9.9457 APE11-dist-na 7.4465 APE10-dist-na 11.9437 APE9-dist-in 5.1904 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 B 268.0 255.0 6 29 29 0 [[417, 668]] 1.0 3sxr Homo sapiens TYR_BMX_HUMAN TYR 3.1e-93 317.8 1.0 260.0 260.0 553 554 555 557 559 445 460 464 533 535 534 536.0 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BTK BTK_HUMAN 3K54A Q06187 392 658 659.0 1N1:1 Type1 Inactive DFGin 4.6816 13.9981 BLAplus -132.68, -179.17 50.27, 30.98 -93.41, -0.42 58.12, 86.77 -82.65, 999.0 in-out in 8.7866 Saltbr-out 3.7709 HRD-in -69.54, -47.61 72.38, -12.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.06 APE8-dihe-in -84.11, 69.82 APE8-rot-na 29.89 APE67-dihe-in -70.22, -9.36 -47.67, -47.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1055 Y551E None None XRAY 1.94 0.202 0.258 A 283.0 243.0 24 29 12 17 [[402, 653]] 1.0 3k54 Homo sapiens TYR_BTK_HUMAN TYR 1.6e-92 315.4 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 3OCTA Q06187 394 656 659.0 1N1:663 Type1 Inactive DFGinter 9.5513 8.0475 BABtrans -83.49, 139.01 -103.95, 15.92 -87.02, 132.92 181.28, 97.3 77.87, 26.97 in-out in 9.203 Saltbr-out 7.7453 HRD-in -70.28, -48.13 67.57, -13.36 out-out-none SNCoon out-none ActLoopNT-out 5.3805 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.42 APE8-dihe-in -60.66, 106.57 APE8-rot-na 28.18 APE67-dihe-in -77.0, -13.84 -55.35, -41.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7096 V555R None None XRAY 1.95 0.199 0.251 A 265.0 244.0 19 29 15 14 [[402, 653]] 1.0 3oct Homo sapiens TYR_BTK_HUMAN TYR 2.3e-93 318.2 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR DDR1 DDR1_HUMAN 6BSDA Q08345 604 912 913.0 1N1:60901 Type1 Inactive DFGinter 9.9484 9.844 None -87.87, 155.34 -64.16, -24.42 174.69, 170.82 68.3, 89.44 55.93, 999.0 in-in in 8.3705 Saltbr-in 2.7354 HRD-in -61.68, -56.93 83.98, -4.33 in-out-in SNCioi out-in ActLoopNT-out 19.8476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.74, 115.57 APE9-dihe-in -116.16, 127.65 APE8-dihe-in -81.76, 68.68 APE8-rot-na 34.21 APE67-dihe-in -66.93, -20.25 -61.43, -30.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1458 None None None XRAY 2.606 0.186 0.255 A 351.0 278.0 31 30 28 2 [[610, 907]] 1.0 6bsd Homo sapiens TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1.0 260.0 260.0 783 784 785 787 789 655 672 676 763 765 764 766.0 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 5BVWA Q08345 604 911 913.0 1N1:1009 Type1 Inactive DFGout 14.538 10.296 None -113.16, 175.58 -102.37, -21.68 40.34, 118.5 221.24, 85.03 -134.54, 999.0 in-in in 8.3337 Saltbr-in 2.775 HRD-in -77.35, -46.96 73.51, -12.24 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.96, 123.56 APE9-dihe-in -122.26, 123.59 APE8-dihe-in -77.84, 65.49 APE8-rot-na 31.29 APE67-dihe-in -69.31, -14.79 -54.53, -34.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.409 None None None XRAY 1.94 0.186 0.234 A 324.0 274.0 34 30 26 4 [[610, 907]] 1.0 5bvw Homo sapiens TYR_DDR1_HUMAN TYR 1.7e-92 315.4 1.0 260.0 260.0 783 784 785 787 789 655 672 676 763 765 764 766.0 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EPHA2 EPHA2_HUMAN 5I9YA P29317 600 896 976.0 1N1:1001 Type1 Inactive DFGin 6.2223 14.973 BLBminus -129.12, 177.86 73.14, 77.74 -114.09, 153.37 295.9, 102.04 147.64, -171.81 in-in in 8.2568 Saltbr-in 2.7741 HRD-in -75.07, -47.16 76.83, -16.24 in-out-none SNCion out-none ActLoopNT-out 10.4586 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 139.34 APE8-rot-na 36.16 APE67-dihe-in -79.28, -3.2 -53.92, -45.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.228 0.164 0.179 A 306.0 287.0 10 31 24 7 [[613, 873]] 1.0 5i9y Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHB4 EPHB4_HUMAN 6FNMA P54760 608 889 987.0 1N1:1001 Type1 Inactive DFGin 5.9609 15.7692 BLBminus -128.55, -169.2 67.78, 75.65 -110.02, 138.75 293.26, 98.41 179.12, 146.16 in-in in 8.3255 Saltbr-in 3.1793 HRD-in -76.03, -51.54 81.54, -15.45 in-out-in SNCioi out-in ActLoopNT-out 10.0097 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 157.69 APE9-dihe-in -64.87, 128.21 APE8-dihe-in -78.96, 90.14 APE8-rot-na 30.03 APE67-dihe-in -61.19, -22.58 -57.17, -48.0 APE12-dist-na 999.0 APE11-dist-na 11.3678 APE10-dist-na 15.0342 APE9-dist-in 6.5764 Y774E,A803V,V870I None None XRAY 1.157 0.184 0.195 A 297.0 270.0 12 33 21 12 [[615, 876]] 1.0 6fnm Homo sapiens TYR_EPHB4_HUMAN TYR 4.2e-105 356.7 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR PTK6 PTK6_HUMAN 5H2UA Q13882 185 446 451.0 1N1:60501 Type1 Inactive DFGin 5.9983 13.4628 BLBplus -115.66, 172.2 65.44, 13.7 -58.08, 130.19 47.49, 85.54 66.94, -1.55 out-out out 14.1683 Saltbr-out 16.091 HRD-in -72.57, -54.48 85.53, -13.44 out-out-out SNCooo out-out ActLoopNT-out 7.2608 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out 72.03, 33.67 APE9-dihe-out -55.65, -32.62 APE8-dihe-out -63.18, -18.16 APE8-rot-na 340.69 APE67-dihe-in -82.41, -18.93 -56.57, -27.65 APE12-dist-na 16.3439 APE11-dist-na 20.6081 APE10-dist-na 18.2629 APE9-dist-out 11.0621 C433T None None XRAY 2.24 0.208 0.26 A 267.0 261.0 1 28 28 0 [[191, 443]] 1.0 5h2u Homo sapiens TYR_PTK6_HUMAN TYR 9.8e-89 303.0 2.0 260.0 259.0 329 330 331 333 335 219 235 239 309 311 310 312.0 369 357 352 351 350 349 348 347 346 265 Protein-tyrosine kinase 6
TYR PTK6 PTK6_HUMAN 5H2UB Q13882 185 446 451.0 1N1:60501 Type1 Inactive DFGin 6.0808 13.3427 BLBplus -112.62, 168.56 69.96, 13.64 -58.15, 126.09 44.9, 88.52 70.74, 0.77 out-out out 14.3036 Saltbr-out 15.9567 HRD-in -65.56, -52.22 84.8, -15.83 out-out-out SNCooo out-out ActLoopNT-out 7.0671 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out 67.1, 31.04 APE9-dihe-out -51.48, -32.62 APE8-dihe-out -56.92, -21.84 APE8-rot-na 331.92 APE67-dihe-in -82.05, -11.15 -61.67, -25.37 APE12-dist-na 16.2609 APE11-dist-na 20.2262 APE10-dist-na 17.9045 APE9-dist-out 11.0552 C433T None None XRAY 2.24 0.208 0.26 B 267.0 261.0 1 28 28 0 [[191, 443]] 1.0 5h2u Homo sapiens TYR_PTK6_HUMAN TYR 9.8e-89 303.0 2.0 260.0 259.0 329 330 331 333 335 219 235 239 309 311 310 312.0 369 357 352 351 350 349 348 347 346 265 Protein-tyrosine kinase 6
TYR PTK6 PTK6_HUMAN 5H2UC Q13882 185 446 451.0 1N1:60501 Type1 Inactive DFGin 5.9677 13.6341 BLBplus -101.49, 165.12 71.33, 11.9 -56.7, 126.68 46.28, 85.99 72.45, -1.55 out-out out 14.2504 Saltbr-out 15.3617 HRD-in -69.3, -53.89 83.99, -9.53 out-out-out SNCooo out-out ActLoopNT-out 7.1583 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out 66.45, 29.68 APE9-dihe-out -47.22, -37.04 APE8-dihe-out -58.56, -24.03 APE8-rot-na 334.48 APE67-dihe-in -84.14, -9.31 -53.24, -25.76 APE12-dist-na 16.3889 APE11-dist-na 20.3117 APE10-dist-na 17.9592 APE9-dist-out 11.0174 C433T None None XRAY 2.24 0.208 0.26 C 267.0 261.0 1 28 28 0 [[191, 443]] 1.0 5h2u Homo sapiens TYR_PTK6_HUMAN TYR 9.8e-89 303.0 2.0 260.0 259.0 329 330 331 333 335 219 235 239 309 311 310 312.0 369 357 352 351 350 349 348 347 346 265 Protein-tyrosine kinase 6
TYR PTK6 PTK6_HUMAN 5H2UD Q13882 185 446 451.0 1N1:60504 Type1 Inactive DFGin 6.1814 13.2695 BLBplus -112.73, 164.13 73.65, 11.67 -56.94, 123.73 42.41, 88.79 73.17, 2.96 out-out out 14.0107 Saltbr-out 15.9929 HRD-in -70.19, -55.11 88.71, -18.22 out-out-out SNCooo out-out ActLoopNT-out 7.1947 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out 72.07, 30.74 APE9-dihe-out -48.72, -36.76 APE8-dihe-out -61.03, -20.74 APE8-rot-na 334.99 APE67-dihe-in -84.77, -13.01 -55.36, -26.11 APE12-dist-na 16.3004 APE11-dist-na 20.346 APE10-dist-na 18.0251 APE9-dist-out 11.0324 C433T None None XRAY 2.24 0.208 0.26 D 267.0 261.0 1 28 28 0 [[191, 443]] 1.0 5h2u Homo sapiens TYR_PTK6_HUMAN TYR 9.8e-89 303.0 2.0 260.0 259.0 329 330 331 333 335 219 235 239 309 311 310 312.0 369 357 352 351 350 349 348 347 346 265 Protein-tyrosine kinase 6
TYR ABL2 ABL2_MOUSE 4XLIA Q4JIM5 279 546 1182.0 1N1:601 Type1.5_Back Inactive DFGin 6.5075 13.6034 BLAminus -146.93, -165.44 45.19, 75.22 -96.7, 24.95 303.43, 100.32 -77.67, 1.06 in-out in 8.1979 Saltbr-out 4.2161 HRD-in -89.85, -46.08 70.33, 6.25 out-in-in SNCoii in-in ActLoopNT-in 2.9692 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.74, 141.9 APE9-dihe-in -130.79, 158.17 APE8-dihe-in -65.12, 108.35 APE8-rot-na 22.1 APE67-dihe-in -73.67, -11.6 -58.5, -43.4 APE12-dist-na 15.3379 APE11-dist-na 10.7818 APE10-dist-na 13.3164 APE9-dist-in 7.1309 None None None XRAY 2.5 0.157 0.205 A 268.0 264.0 4 29 29 0 [[288, 541]] 1.0 4xli Mus musculus TYR_ABL2_MOUSE TYR 2e-98 334.8 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
TYR ABL2 ABL2_MOUSE 4XLIB Q4JIM5 279 546 1182.0 1N1:600 Type1.5_Back Active DFGin 6.3912 13.6381 BLAminus -131.7, -165.09 47.95, 80.18 -101.55, 32.58 307.48, 89.21 -70.05, -27.33 in-in in 8.2287 Saltbr-in 2.5374 HRD-in -85.97, -54.42 80.41, 14.17 in-in-in SNCiii in-in ActLoopNT-in 3.1 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.09, 129.65 APE9-dihe-in -110.16, 158.75 APE8-dihe-in -72.12, 103.04 APE8-rot-na 29.85 APE67-dihe-in -62.36, -22.19 -57.39, -43.34 APE12-dist-na 15.0495 APE11-dist-na 10.2063 APE10-dist-na 12.5948 APE9-dist-in 7.0962 None None None XRAY 2.5 0.157 0.205 B 268.0 264.0 4 29 29 0 [[288, 541]] 1.0 4xli Mus musculus TYR_ABL2_MOUSE TYR 2e-98 334.8 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
TYR BTK BTK_MOUSE 8S9FA P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.7383 8.4773 BABtrans -103.75, 162.9 -98.62, -12.56 -74.46, 134.73 203.6, 82.29 75.53, 30.46 out-out out 11.3245 Saltbr-out 8.457 HRD-out -78.16, 120.76 -71.26, -27.71 out-out-none SNCoon out-none ActLoopNT-out 5.4638 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 89.3 APE8-rot-na 354.27 APE67-dihe-in -88.28, 1.83 -66.03, -37.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 A 279.0 254.0 14 29 15 14 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 8S9FB P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.5087 8.4716 BABtrans -108.61, 149.63 -109.15, 7.92 -82.22, 131.91 185.43, 98.64 78.7, 27.48 out-out out 11.0192 Saltbr-out 10.3295 HRD-out -91.58, 112.75 -69.14, -29.29 out-out-out SNCooo out-out ActLoopNT-out 5.6813 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 166.92 APE9-dihe-in -91.32, 115.75 APE8-dihe-in -71.7, 107.6 APE8-rot-na 25.58 APE67-dihe-in -83.25, -12.58 -54.13, -30.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.1492 APE9-dist-out 18.604 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 B 279.0 255.0 13 29 17 12 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR EPHA4 EPHA4_MOUSE 2Y6OA Q03137 609 891 986.0 1N1:1892 Type1 Inactive DFGin 6.5237 15.3156 None -125.69, -163.2 68.45, 65.65 -111.22, 999.0 295.37, 106.51 999.0, 999.0 in-in in 8.2042 Saltbr-in 2.6896 HRD-in -74.99, -48.94 76.82, -16.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.47 APE8-dihe-in -69.65, 86.1 APE8-rot-na 27.26 APE67-dihe-in -78.79, 0.73 -48.0, -50.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6377 None None None XRAY 1.543 0.181 0.201 A 291.0 263.0 20 31 11 20 [[621, 880]] 1.0 2y6o Mus musculus TYR_EPHA4_MOUSE TYR 1.6e-109 371.2 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
TYR LYN LYN_MOUSE 2ZVAA P25911 239 502 512.0 1N1:60513 Type1.5_Back Inactive DFGin 6.4453 13.8753 BLAminus -120.49, -171.3 46.11, 83.42 -100.41, 24.42 303.87, 89.77 -59.23, -40.1 in-in in 8.3149 Saltbr-in 2.7526 HRD-naN -93.32, -50.56 73.54, -8.83 in-in-out SNCiio in-out ActLoopNT-in 2.7284 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 87.79, 115.97 APE9-dihe-in -82.02, 152.26 APE8-dihe-in -82.89, 88.6 APE8-rot-na 28.7 APE67-dihe-in -67.8, -12.1 -43.08, -51.75 APE12-dist-na 10.4403 APE11-dist-na 6.3096 APE10-dist-na 9.4506 APE9-dist-in 5.3495 None None None XRAY 2.6 0.199 0.231 A 279.0 260.0 4 29 25 4 [[247, 499]] 1.0 2zva Mus musculus TYR_LYN_MOUSE TYR 4.1e-95 323.9 1.0 260.0 260.0 384 385 386 388 390 275 290 294 364 366 365 367.0 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
CMGC P38A A9UJZ9_SALSA 3OHTA A9UJZ9 5 352 361.0 1N1:1000,1N1:2000 Type1.5_Back,Allosteric Inactive DFGout 13.5799 9.5849 None -78.92, -176.24 -106.96, 26.33 -169.7, 165.77 77.85, 98.84 145.96, 999.0 in-in in 9.1763 Saltbr-in 2.7252 HRD-out -88.45, 143.68 -105.73, 98.3 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.235 0.289 A 389.0 331.0 17 25 8 17 [[25, 309]] 1.0 3oht Salmo salar CMGC_P38A_SALSA CMGC 2.1e-83 286.2 1.0 301.0 301.0 168 169 170 172 174 54 72 76 148 150 149 151.0 206 193 188 187 186 185 184 183 182 108 mitogen-activated protein kinase
CMGC P38A A9UJZ9_SALSA 3OHTB A9UJZ9 5 352 361.0 1N1:1000,1N1:2000 Type1.5_Back,Allosteric Inactive DFGout 13.3516 9.2901 None -90.67, 172.5 -94.08, 34.32 -176.15, 166.37 74.91, 100.91 -151.94, 999.0 in-in in 9.1457 Saltbr-in 2.7005 HRD-out -93.8, 126.44 -88.56, 105.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.235 0.289 B 389.0 331.0 17 25 8 17 [[25, 309]] 1.0 3oht Salmo salar CMGC_P38A_SALSA CMGC 2.1e-83 286.2 1.0 301.0 301.0 168 169 170 172 174 54 72 76 148 150 149 151.0 206 193 188 187 186 185 184 183 182 108 mitogen-activated protein kinase

Ligand: 1N1 (Dasatinib)

Total number of chains: 12
Active chains: 1
Total number of genes: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 7 58.3% 4XLIA
DFGinter BABtrans 2 16.7% 8S9FB
DFGout None 2 16.7% 3OHTA
DFGin None 1 8.3% 2Y6OA

Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3QLGA P00523 258 533 533.0 1N1:601 Type1.5_Back Inactive DFGin 6.5502 13.8381 BLAminus -128.97, 169.0 62.45, 93.12 -106.99, 6.4 306.69, 101.34 -122.4, 999.0 in-in in 8.7224 Saltbr-in 2.9531 HRD-in -90.7, -55.87 92.28, -19.25 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.4 APE8-dihe-in -85.59, 52.69 APE8-rot-na 6.03 APE67-dihe-in -68.2, -8.8 -50.34, -41.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.1548 L317I None None XRAY 2.75 0.203 0.269 A 286.0 259.0 17 29 12 17 [[267, 518]] 1.0 3qlg Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3QLGB P00523 256 533 533.0 1N1:601 Type1.5_Back Inactive DFGin 6.2634 13.1722 BLAminus -132.53, 169.92 55.67, 96.64 -114.48, 23.35 323.76, 73.27 -64.65, -16.14 in-in in 8.523 Saltbr-in 2.7156 HRD-in -89.78, -56.21 92.27, -19.49 in-in-out SNCiio in-out ActLoopNT-in 3.1877 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.14 APE8-dihe-in -84.28, 53.37 APE8-rot-na 5.94 APE67-dihe-in -68.54, -8.95 -50.64, -40.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0573 L317I None None XRAY 2.75 0.203 0.269 B 286.0 260.0 18 29 16 13 [[267, 518]] 1.0 3qlg Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3G5DA P00523 257 533 533.0 1N1:1 Type1.5_Back None DFGin 6.7191 14.1749 BLAminus -122.29, -173.62 52.53, 77.9 -96.14, 20.03 300.27, 89.98 -55.15, -32.52 in-in in 8.2259 Saltbr-in 3.4707 HRD-in -89.79, -51.87 81.03, -11.33 in-in-none SNCiin in-none ActLoopNT-in 3.1848 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.62 APE8-dihe-in -62.24, 114.12 APE8-rot-na 23.22 APE67-dihe-in -69.68, -25.09 -60.39, -25.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.7563 S345C None None XRAY 2.2 0.207 0.257 A 286.0 256.0 21 29 16 13 [[267, 518]] 1.0 3g5d Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3G5DB P00523 258 533 533.0 1N1:1 Type1.5_Back None DFGin 6.2754 13.5136 BLAminus -124.9, 179.31 57.13, 77.85 -97.54, 21.78 318.72, 94.26 -57.84, -11.35 in-in in 8.332 Saltbr-in 2.9563 HRD-in -82.76, -54.14 84.2, -12.02 in-in-none SNCiin in-none ActLoopNT-in 3.1515 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.98 APE8-dihe-in -55.02, 101.46 APE8-rot-na 16.54 APE67-dihe-in -66.6, -25.87 -58.78, -30.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.0801 S345C None None XRAY 2.2 0.207 0.257 B 286.0 257.0 19 29 16 13 [[267, 518]] 1.0 3g5d Gallus gallus TYR_SRC_CHICK TYR 4.5e-94 320.5 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR ABL2 ABL2_MOUSE 4XLIA Q4JIM5 279 546 1182.0 1N1:601 Type1.5_Back Inactive DFGin 6.5075 13.6034 BLAminus -146.93, -165.44 45.19, 75.22 -96.7, 24.95 303.43, 100.32 -77.67, 1.06 in-out in 8.1979 Saltbr-out 4.2161 HRD-in -89.85, -46.08 70.33, 6.25 out-in-in SNCoii in-in ActLoopNT-in 2.9692 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.74, 141.9 APE9-dihe-in -130.79, 158.17 APE8-dihe-in -65.12, 108.35 APE8-rot-na 22.1 APE67-dihe-in -73.67, -11.6 -58.5, -43.4 APE12-dist-na 15.3379 APE11-dist-na 10.7818 APE10-dist-na 13.3164 APE9-dist-in 7.1309 None None None XRAY 2.5 0.157 0.205 A 268.0 264.0 4 29 29 0 [[288, 541]] 1.0 4xli Mus musculus TYR_ABL2_MOUSE TYR 2e-98 334.8 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
TYR ABL2 ABL2_MOUSE 4XLIB Q4JIM5 279 546 1182.0 1N1:600 Type1.5_Back Active DFGin 6.3912 13.6381 BLAminus -131.7, -165.09 47.95, 80.18 -101.55, 32.58 307.48, 89.21 -70.05, -27.33 in-in in 8.2287 Saltbr-in 2.5374 HRD-in -85.97, -54.42 80.41, 14.17 in-in-in SNCiii in-in ActLoopNT-in 3.1 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.09, 129.65 APE9-dihe-in -110.16, 158.75 APE8-dihe-in -72.12, 103.04 APE8-rot-na 29.85 APE67-dihe-in -62.36, -22.19 -57.39, -43.34 APE12-dist-na 15.0495 APE11-dist-na 10.2063 APE10-dist-na 12.5948 APE9-dist-in 7.0962 None None None XRAY 2.5 0.157 0.205 B 268.0 264.0 4 29 29 0 [[288, 541]] 1.0 4xli Mus musculus TYR_ABL2_MOUSE TYR 2e-98 334.8 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
TYR BTK BTK_MOUSE 8S9FA P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.7383 8.4773 BABtrans -103.75, 162.9 -98.62, -12.56 -74.46, 134.73 203.6, 82.29 75.53, 30.46 out-out out 11.3245 Saltbr-out 8.457 HRD-out -78.16, 120.76 -71.26, -27.71 out-out-none SNCoon out-none ActLoopNT-out 5.4638 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 89.3 APE8-rot-na 354.27 APE67-dihe-in -88.28, 1.83 -66.03, -37.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 A 279.0 254.0 14 29 15 14 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 8S9FB P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.5087 8.4716 BABtrans -108.61, 149.63 -109.15, 7.92 -82.22, 131.91 185.43, 98.64 78.7, 27.48 out-out out 11.0192 Saltbr-out 10.3295 HRD-out -91.58, 112.75 -69.14, -29.29 out-out-out SNCooo out-out ActLoopNT-out 5.6813 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 166.92 APE9-dihe-in -91.32, 115.75 APE8-dihe-in -71.7, 107.6 APE8-rot-na 25.58 APE67-dihe-in -83.25, -12.58 -54.13, -30.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.1492 APE9-dist-out 18.604 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 B 279.0 255.0 13 29 17 12 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR EPHA4 EPHA4_MOUSE 2Y6OA Q03137 609 891 986.0 1N1:1892 Type1 Inactive DFGin 6.5237 15.3156 None -125.69, -163.2 68.45, 65.65 -111.22, 999.0 295.37, 106.51 999.0, 999.0 in-in in 8.2042 Saltbr-in 2.6896 HRD-in -74.99, -48.94 76.82, -16.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.47 APE8-dihe-in -69.65, 86.1 APE8-rot-na 27.26 APE67-dihe-in -78.79, 0.73 -48.0, -50.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6377 None None None XRAY 1.543 0.181 0.201 A 291.0 263.0 20 31 11 20 [[621, 880]] 1.0 2y6o Mus musculus TYR_EPHA4_MOUSE TYR 1.6e-109 371.2 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
TYR LYN LYN_MOUSE 2ZVAA P25911 239 502 512.0 1N1:60513 Type1.5_Back Inactive DFGin 6.4453 13.8753 BLAminus -120.49, -171.3 46.11, 83.42 -100.41, 24.42 303.87, 89.77 -59.23, -40.1 in-in in 8.3149 Saltbr-in 2.7526 HRD-naN -93.32, -50.56 73.54, -8.83 in-in-out SNCiio in-out ActLoopNT-in 2.7284 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 87.79, 115.97 APE9-dihe-in -82.02, 152.26 APE8-dihe-in -82.89, 88.6 APE8-rot-na 28.7 APE67-dihe-in -67.8, -12.1 -43.08, -51.75 APE12-dist-na 10.4403 APE11-dist-na 6.3096 APE10-dist-na 9.4506 APE9-dist-in 5.3495 None None None XRAY 2.6 0.199 0.231 A 279.0 260.0 4 29 25 4 [[247, 499]] 1.0 2zva Mus musculus TYR_LYN_MOUSE TYR 4.1e-95 323.9 1.0 260.0 260.0 384 385 386 388 390 275 290 294 364 366 365 367.0 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
CMGC P38A A9UJZ9_SALSA 3OHTA A9UJZ9 5 352 361.0 1N1:1000,1N1:2000 Type1.5_Back,Allosteric Inactive DFGout 13.5799 9.5849 None -78.92, -176.24 -106.96, 26.33 -169.7, 165.77 77.85, 98.84 145.96, 999.0 in-in in 9.1763 Saltbr-in 2.7252 HRD-out -88.45, 143.68 -105.73, 98.3 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.235 0.289 A 389.0 331.0 17 25 8 17 [[25, 309]] 1.0 3oht Salmo salar CMGC_P38A_SALSA CMGC 2.1e-83 286.2 1.0 301.0 301.0 168 169 170 172 174 54 72 76 148 150 149 151.0 206 193 188 187 186 185 184 183 182 108 mitogen-activated protein kinase
CMGC P38A A9UJZ9_SALSA 3OHTB A9UJZ9 5 352 361.0 1N1:1000,1N1:2000 Type1.5_Back,Allosteric Inactive DFGout 13.3516 9.2901 None -90.67, 172.5 -94.08, 34.32 -176.15, 166.37 74.91, 100.91 -151.94, 999.0 in-in in 9.1457 Saltbr-in 2.7005 HRD-out -93.8, 126.44 -88.56, 105.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.235 0.289 B 389.0 331.0 17 25 8 17 [[25, 309]] 1.0 3oht Salmo salar CMGC_P38A_SALSA CMGC 2.1e-83 286.2 1.0 301.0 301.0 168 169 170 172 174 54 72 76 148 150 149 151.0 206 193 188 187 186 185 184 183 182 108 mitogen-activated protein kinase