OTHER_WNK1 (Serine/threonine-protein kinase WNK1)

Total number of chains: 9
Active chains: 2
Uniprot: WNK1_HUMAN
Kinase Domain Residues: 220 - 479
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 88.9% AF-Q9H4A3-K1A
DFGin None 1 11.1% 4PWNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q9H4A3-K1A -1.0 Active DFGin‑BLAminus out-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 212 - 487 0 None None Serine/threonine-protein kinase WNK1
AF-Q9H4A3-K3A -1.0 Active DFGin‑BLAminus out-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 212 - 487 0 None None Serine/threonine-protein kinase WNK1
5WDYB 2.458 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, A6S ATPlike, Type3 206 - 480 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1
5WE8A 2.006 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaioo APEdist_oooo ANP, A7Y ATPlike, Type3 209 - 483 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1
5WE8B 2.006 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaiio APEdist_oooo ANP, A7Y ATPlike, Type3 207 - 480 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1
5TF9A 2.5 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaioo APEdist_nnno 7AV, ANP Type3, ATPlike 210 - 483 0 None None Serine/threonine-protein kinase WNK1
5TF9B 2.5 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaiio APEdist_nnno 7AV, ANP Type3, ATPlike 206 - 480 0 None None Serine/threonine-protein kinase WNK1
4PWNA 1.84 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 210 - 482 0 None None Serine/threonine-protein kinase WNK1
5WDYA 2.458 None DFGin‑BLAminus out-na in-none nonTYR APEdihe_aannn APEdist_nnnn ANP, A6S ATPlike, Type3 208 - 481 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1

OTHER_WNK1 (Serine/threonine-protein kinase WNK1)

Total number of chains: 18
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 61.1% AF-Q9H4A3-K1A
DFGin BLBminus 3 16.7% 6CN9B
DFGin BLBtrans 3 16.7% 5DRBA
DFGin None 1 5.6% 4PWNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
WNK1_HUMAN AF-Q9H4A3-K1A -1.0 Active DFGin‑BLAminus out-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 212 - 487 0 None None Serine/threonine-protein kinase WNK1 Homo sapiens
WNK1_HUMAN AF-Q9H4A3-K3A -1.0 Active DFGin‑BLAminus out-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 212 - 487 0 None None Serine/threonine-protein kinase WNK1 Homo sapiens
WNK1_HUMAN 5WDYB 2.458 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, A6S ATPlike, Type3 206 - 480 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1 Homo sapiens
WNK1_HUMAN 5WE8A 2.006 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaioo APEdist_oooo ANP, A7Y ATPlike, Type3 209 - 483 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1 Homo sapiens
WNK1_HUMAN 5WE8B 2.006 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaiio APEdist_oooo ANP, A7Y ATPlike, Type3 207 - 480 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1 Homo sapiens
WNK1_HUMAN 5TF9A 2.5 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaioo APEdist_nnno 7AV, ANP Type3, ATPlike 210 - 483 0 None None Serine/threonine-protein kinase WNK1 Homo sapiens
WNK1_HUMAN 5TF9B 2.5 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaiio APEdist_nnno 7AV, ANP Type3, ATPlike 206 - 480 0 None None Serine/threonine-protein kinase WNK1 Homo sapiens
WNK1_HUMAN 4PWNA 1.84 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 210 - 482 0 None None Serine/threonine-protein kinase WNK1 Homo sapiens
WNK1_HUMAN 5WDYA 2.458 None DFGin‑BLAminus out-na in-none nonTYR APEdihe_aannn APEdist_nnnn ANP, A6S ATPlike, Type3 208 - 481 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1 Homo sapiens
WNK1_RAT 9D3FA 2.0 Inactive DFGin‑BLAminus out-na out-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 211 - 482 0 None None Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 6CN9A 1.8 Inactive DFGin‑BLAminus out-na out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 210 - 480 0 None None Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 4Q2AA 3.5 Inactive DFGin‑BLAminus out-na out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 210 - 480 0 None S382A Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 6CN9B 1.8 Inactive DFGin‑BLBminus out-na out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 210 - 481 0 None None Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 7UOSA 2.9 Inactive DFGin‑BLBminus out-na out-out nonTYR APEdihe_aaiio APEdist_oooo WIB Type1 211 - 481 0 None S382A Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 6OL2A 2.1 Inactive DFGin‑BLBminus out-na out-out nonTYR APEdihe_aaiio APEdist_oooo MU7 Type1.5_Back 203 - 481 0 None S382A Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 5W7TA 2.01 Inactive DFGin‑BLBtrans out-na out-out nonTYR APEdihe_aaiii APEdist_oioi ANP ATPlike 210 - 482 0 SEP382 None Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 5W7TB 2.01 Inactive DFGin‑BLBtrans out-na out-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 210 - 482 0 SEP382 None Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 5DRBA 1.65 Inactive DFGin‑BLBtrans out-na out-out nonTYR APEdihe_aaioo APEdist_oooo 5FJ Type1.5_Front 209 - 481 0 None S382A Serine/threonine-protein kinase WNK1 Rattus norvegicus

OTHER_WNK1 (Serine/threonine-protein kinase WNK1)

Total number of chains: 9
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 33.3% 6CN9A
DFGin BLBminus 3 33.3% 6CN9B
DFGin BLBtrans 3 33.3% 5DRBA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
WNK1_RAT 9D3FA 2.0 Inactive DFGin‑BLAminus out-na out-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 211 - 482 0 None None Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 6CN9A 1.8 Inactive DFGin‑BLAminus out-na out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 210 - 480 0 None None Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 4Q2AA 3.5 Inactive DFGin‑BLAminus out-na out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 210 - 480 0 None S382A Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 6CN9B 1.8 Inactive DFGin‑BLBminus out-na out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 210 - 481 0 None None Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 7UOSA 2.9 Inactive DFGin‑BLBminus out-na out-out nonTYR APEdihe_aaiio APEdist_oooo WIB Type1 211 - 481 0 None S382A Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 6OL2A 2.1 Inactive DFGin‑BLBminus out-na out-out nonTYR APEdihe_aaiio APEdist_oooo MU7 Type1.5_Back 203 - 481 0 None S382A Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 5W7TA 2.01 Inactive DFGin‑BLBtrans out-na out-out nonTYR APEdihe_aaiii APEdist_oioi ANP ATPlike 210 - 482 0 SEP382 None Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 5W7TB 2.01 Inactive DFGin‑BLBtrans out-na out-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 210 - 482 0 SEP382 None Serine/threonine-protein kinase WNK1 Rattus norvegicus
WNK1_RAT 5DRBA 1.65 Inactive DFGin‑BLBtrans out-na out-out nonTYR APEdihe_aaioo APEdist_oooo 5FJ Type1.5_Front 209 - 481 0 None S382A Serine/threonine-protein kinase WNK1 Rattus norvegicus