OTHER_WNK1 (Serine/threonine-protein kinase WNK1)

Total number of chains: 9
Active chains: 2
Uniprot: WNK1_HUMAN
Kinase Domain Residues: 220 - 479
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 88.9% AF-Q9H4A3-K1A
DFGin None 1 11.1% 4PWNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
WNK1 AF-Q9H4A3-K1A Q9H4A3 212 487 2382.0 No_ligand No_ligand Active DFGin 6.9194 12.2667 BLAminus -124.85, -163.73 58.77, 48.81 -69.2, 9.5 304.02, 175.87 -66.92, -19.2 out-na out 15.0438 Saltbr-na 999.0 HRD-in -70.23, -44.77 64.66, -7.25 na-in-in SNCaii in-in ActLoopNT-in 2.9534 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.96, 148.96 APE9-dihe-na 141.57, -179.67 APE8-dihe-in -82.64, 118.12 APE8-rot-in 302.58 APE67-dihe-in -65.7, -18.39 -50.97, -36.48 APE12-dist-in 8.5986 APE11-dist-in 11.9677 APE10-dist-in 6.2868 APE9-dist-in 3.5836 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 26 26 0 [[220, 479]] 1.0 AF-Q9H4A3-K1 OTHER_WNK1_HUMAN WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 AF-Q9H4A3-K3A Q9H4A3 212 487 2382.0 No_ligand No_ligand Active DFGin 6.7621 12.8927 BLAminus -125.6, -163.55 58.64, 42.4 -66.13, 8.03 302.27, 174.42 -67.33, -13.09 out-na out 14.2924 Saltbr-na 999.0 HRD-in -73.13, -42.78 63.87, -11.34 na-in-in SNCaii in-in ActLoopNT-in 2.9127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.46, 136.63 APE9-dihe-na 153.75, -172.1 APE8-dihe-in -96.01, 118.63 APE8-rot-in 299.38 APE67-dihe-in -65.38, -19.38 -50.44, -37.25 APE12-dist-in 9.024 APE11-dist-in 12.0761 APE10-dist-in 6.5207 APE9-dist-in 3.4862 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 26 26 0 [[220, 479]] 1.0 AF-Q9H4A3-K3 OTHER_WNK1_HUMAN WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 5WDYB Q9H4A3 206 480 2382.0 ANP:502,A6S:503 ATPlike,Type3 Inactive DFGin 7.3697 14.5039 BLAminus -142.95, -168.2 54.59, 81.56 -95.94, 38.03 311.01, 0.7 -70.23, -38.22 out-na out 15.6644 Saltbr-na 999.0 HRD-in -73.48, -49.35 66.41, -10.51 na-in-out SNCaio in-out ActLoopNT-in 2.8562 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -28.04 APE8-rot-out 62.13 APE67-dihe-out -96.17, -54.53 -53.63, 160.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 B 279.0 259.0 16 26 17 9 [[220, 479]] 1.0 5wdy OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 5WE8A Q9H4A3 209 483 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.2406 14.0323 BLAminus -121.41, -171.4 57.02, 71.32 -89.03, 25.94 306.74, 15.86 -67.83, -33.81 out-na out 15.5061 Saltbr-na 999.0 HRD-in -66.1, -48.39 70.94, -12.37 na-in-out SNCaio in-out ActLoopNT-in 2.8473 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -77.54, 145.45 APE9-dihe-na 132.01, 166.25 APE8-dihe-in -145.73, 139.85 APE8-rot-out 178.66 APE67-dihe-out -92.59, -40.75 -69.19, 149.7 APE12-dist-out 20.1345 APE11-dist-out 22.4082 APE10-dist-out 25.4016 APE9-dist-out 25.9281 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 A 279.0 270.0 5 26 26 0 [[220, 479]] 1.0 5we8 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 5WE8B Q9H4A3 207 480 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.5758 14.7327 BLAminus -124.5, -174.3 56.61, 76.82 -93.57, 20.89 272.49, 56.06 -64.65, -35.23 out-na out 15.2517 Saltbr-na 999.0 HRD-in -64.68, -49.22 72.3, -10.07 na-in-out SNCaio in-out ActLoopNT-in 2.8196 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -86.7, 136.01 APE9-dihe-na 147.23, 150.88 APE8-dihe-in -131.74, 126.21 APE8-rot-in 297.77 APE67-dihe-out -91.94, -28.57 -59.79, 145.49 APE12-dist-out 19.935 APE11-dist-out 22.7259 APE10-dist-out 25.875 APE9-dist-out 25.6143 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 B 279.0 272.0 2 26 26 0 [[220, 479]] 1.0 5we8 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 5TF9A Q9H4A3 210 483 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.7987 14.8055 BLAminus -124.68, -165.52 44.5, 74.88 -89.64, 28.71 274.12, 71.89 -66.6, -24.41 out-na out 15.6375 Saltbr-na 999.0 HRD-in -62.68, -52.45 73.71, -6.51 na-in-out SNCaio in-out ActLoopNT-in 2.8684 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 175.52 APE8-dihe-in -127.14, 129.36 APE8-rot-out 176.04 APE67-dihe-out -84.82, -53.84 -65.86, 145.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.0919 None None None XRAY 2.5 0.198 0.266 A 279.0 262.0 12 26 17 9 [[220, 479]] 1.0 5tf9 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 5TF9B Q9H4A3 206 480 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.7453 14.5813 BLAminus -133.01, -172.41 51.04, 69.52 -83.58, 20.61 265.53, 72.73 -66.77, -27.15 out-na out 14.8615 Saltbr-na 999.0 HRD-in -69.24, -45.67 70.25, -7.52 na-in-out SNCaio in-out ActLoopNT-in 2.9022 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -166.32 APE8-dihe-in -143.09, 133.87 APE8-rot-in 278.07 APE67-dihe-out -99.53, -28.5 -65.98, 144.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.5987 None None None XRAY 2.5 0.198 0.266 B 279.0 266.0 9 26 17 9 [[220, 479]] 1.0 5tf9 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 4PWNA Q9H4A3 210 482 2382.0 No_ligand No_ligand Inactive DFGin 7.0567 13.279 None -116.45, -167.58 52.85, 34.92 -53.76, -53.16 298.89, 177.5 -76.46, 5.08 out-na out 14.364 Saltbr-na 999.0 HRD-in -62.97, -49.68 71.0, -9.34 na-out-none SNCaon out-none ActLoopNT-out 7.5238 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 153.02 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.84 0.231 0.274 A 274.0 245.0 28 26 13 13 [[220, 479]] 1.0 4pwn OTHER_WNK1_HUMAN WNK 9e-179 598.1 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 5WDYA Q9H4A3 208 481 2382.0 ANP:901,A6S:902 ATPlike,Type3 None DFGin 7.9646 14.3105 BLAminus -123.5, -167.41 55.36, 79.67 -97.29, 28.92 280.94, 63.73 -64.29, -44.25 out-na out 15.4122 Saltbr-na 999.0 HRD-in -68.16, -49.86 71.58, -14.71 na-in-none SNCain in-none ActLoopNT-in 3.0135 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -108.13, -60.96 999.0, 157.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 A 279.0 260.0 14 26 17 9 [[220, 479]] 1.0 5wdy OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1

OTHER_WNK1 (Serine/threonine-protein kinase WNK1)

Total number of chains: 18
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 61.1% AF-Q9H4A3-K1A
DFGin BLBminus 3 16.7% 6CN9B
DFGin BLBtrans 3 16.7% 5DRBA
DFGin None 1 5.6% 4PWNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
WNK1 WNK1_HUMAN AF-Q9H4A3-K1A Q9H4A3 212 487 2382.0 No_ligand No_ligand Active DFGin 6.9194 12.2667 BLAminus -124.85, -163.73 58.77, 48.81 -69.2, 9.5 304.02, 175.87 -66.92, -19.2 out-na out 15.0438 Saltbr-na 999.0 HRD-in -70.23, -44.77 64.66, -7.25 na-in-in SNCaii in-in ActLoopNT-in 2.9534 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.96, 148.96 APE9-dihe-na 141.57, -179.67 APE8-dihe-in -82.64, 118.12 APE8-rot-in 302.58 APE67-dihe-in -65.7, -18.39 -50.97, -36.48 APE12-dist-in 8.5986 APE11-dist-in 11.9677 APE10-dist-in 6.2868 APE9-dist-in 3.5836 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 26 26 0 [[220, 479]] 1.0 AF-Q9H4A3-K1 Homo sapiens OTHER_WNK1_HUMAN WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_HUMAN AF-Q9H4A3-K3A Q9H4A3 212 487 2382.0 No_ligand No_ligand Active DFGin 6.7621 12.8927 BLAminus -125.6, -163.55 58.64, 42.4 -66.13, 8.03 302.27, 174.42 -67.33, -13.09 out-na out 14.2924 Saltbr-na 999.0 HRD-in -73.13, -42.78 63.87, -11.34 na-in-in SNCaii in-in ActLoopNT-in 2.9127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.46, 136.63 APE9-dihe-na 153.75, -172.1 APE8-dihe-in -96.01, 118.63 APE8-rot-in 299.38 APE67-dihe-in -65.38, -19.38 -50.44, -37.25 APE12-dist-in 9.024 APE11-dist-in 12.0761 APE10-dist-in 6.5207 APE9-dist-in 3.4862 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 26 26 0 [[220, 479]] 1.0 AF-Q9H4A3-K3 Homo sapiens OTHER_WNK1_HUMAN WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_HUMAN 5WDYB Q9H4A3 206 480 2382.0 ANP:502,A6S:503 ATPlike,Type3 Inactive DFGin 7.3697 14.5039 BLAminus -142.95, -168.2 54.59, 81.56 -95.94, 38.03 311.01, 0.7 -70.23, -38.22 out-na out 15.6644 Saltbr-na 999.0 HRD-in -73.48, -49.35 66.41, -10.51 na-in-out SNCaio in-out ActLoopNT-in 2.8562 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -28.04 APE8-rot-out 62.13 APE67-dihe-out -96.17, -54.53 -53.63, 160.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 B 279.0 259.0 16 26 17 9 [[220, 479]] 1.0 5wdy Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_HUMAN 5WE8A Q9H4A3 209 483 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.2406 14.0323 BLAminus -121.41, -171.4 57.02, 71.32 -89.03, 25.94 306.74, 15.86 -67.83, -33.81 out-na out 15.5061 Saltbr-na 999.0 HRD-in -66.1, -48.39 70.94, -12.37 na-in-out SNCaio in-out ActLoopNT-in 2.8473 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -77.54, 145.45 APE9-dihe-na 132.01, 166.25 APE8-dihe-in -145.73, 139.85 APE8-rot-out 178.66 APE67-dihe-out -92.59, -40.75 -69.19, 149.7 APE12-dist-out 20.1345 APE11-dist-out 22.4082 APE10-dist-out 25.4016 APE9-dist-out 25.9281 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 A 279.0 270.0 5 26 26 0 [[220, 479]] 1.0 5we8 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_HUMAN 5WE8B Q9H4A3 207 480 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.5758 14.7327 BLAminus -124.5, -174.3 56.61, 76.82 -93.57, 20.89 272.49, 56.06 -64.65, -35.23 out-na out 15.2517 Saltbr-na 999.0 HRD-in -64.68, -49.22 72.3, -10.07 na-in-out SNCaio in-out ActLoopNT-in 2.8196 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -86.7, 136.01 APE9-dihe-na 147.23, 150.88 APE8-dihe-in -131.74, 126.21 APE8-rot-in 297.77 APE67-dihe-out -91.94, -28.57 -59.79, 145.49 APE12-dist-out 19.935 APE11-dist-out 22.7259 APE10-dist-out 25.875 APE9-dist-out 25.6143 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 B 279.0 272.0 2 26 26 0 [[220, 479]] 1.0 5we8 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_HUMAN 5TF9A Q9H4A3 210 483 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.7987 14.8055 BLAminus -124.68, -165.52 44.5, 74.88 -89.64, 28.71 274.12, 71.89 -66.6, -24.41 out-na out 15.6375 Saltbr-na 999.0 HRD-in -62.68, -52.45 73.71, -6.51 na-in-out SNCaio in-out ActLoopNT-in 2.8684 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 175.52 APE8-dihe-in -127.14, 129.36 APE8-rot-out 176.04 APE67-dihe-out -84.82, -53.84 -65.86, 145.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.0919 None None None XRAY 2.5 0.198 0.266 A 279.0 262.0 12 26 17 9 [[220, 479]] 1.0 5tf9 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_HUMAN 5TF9B Q9H4A3 206 480 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.7453 14.5813 BLAminus -133.01, -172.41 51.04, 69.52 -83.58, 20.61 265.53, 72.73 -66.77, -27.15 out-na out 14.8615 Saltbr-na 999.0 HRD-in -69.24, -45.67 70.25, -7.52 na-in-out SNCaio in-out ActLoopNT-in 2.9022 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -166.32 APE8-dihe-in -143.09, 133.87 APE8-rot-in 278.07 APE67-dihe-out -99.53, -28.5 -65.98, 144.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.5987 None None None XRAY 2.5 0.198 0.266 B 279.0 266.0 9 26 17 9 [[220, 479]] 1.0 5tf9 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_HUMAN 4PWNA Q9H4A3 210 482 2382.0 No_ligand No_ligand Inactive DFGin 7.0567 13.279 None -116.45, -167.58 52.85, 34.92 -53.76, -53.16 298.89, 177.5 -76.46, 5.08 out-na out 14.364 Saltbr-na 999.0 HRD-in -62.97, -49.68 71.0, -9.34 na-out-none SNCaon out-none ActLoopNT-out 7.5238 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 153.02 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.84 0.231 0.274 A 274.0 245.0 28 26 13 13 [[220, 479]] 1.0 4pwn Homo sapiens OTHER_WNK1_HUMAN WNK 9e-179 598.1 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_HUMAN 5WDYA Q9H4A3 208 481 2382.0 ANP:901,A6S:902 ATPlike,Type3 None DFGin 7.9646 14.3105 BLAminus -123.5, -167.41 55.36, 79.67 -97.29, 28.92 280.94, 63.73 -64.29, -44.25 out-na out 15.4122 Saltbr-na 999.0 HRD-in -68.16, -49.86 71.58, -14.71 na-in-none SNCain in-none ActLoopNT-in 3.0135 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -108.13, -60.96 999.0, 157.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 A 279.0 260.0 14 26 17 9 [[220, 479]] 1.0 5wdy Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 9D3FA Q9JIH7 211 482 2126.0 No_ligand No_ligand Inactive DFGin 6.7872 13.9312 BLAminus -130.3, -171.09 52.28, 49.58 -77.43, -37.54 265.63, 179.36 -61.03, -48.02 out-na out 16.3912 Saltbr-na 999.0 HRD-in -67.67, -64.43 83.35, 3.34 na-out-out SNCaoo out-out ActLoopNT-out 6.6697 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.38 APE8-rot-none 999.0 APE67-dihe-out -124.38, -140.72 -73.34, 137.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.206 0.236 A 290.0 265.0 7 26 19 7 [[220, 479]] 1.0 9d3f Rattus norvegicus OTHER_WNK1_RAT WNK 5.1e-180 602.2 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 6CN9A Q9JIH7 210 480 2126.0 No_ligand No_ligand Inactive DFGin 7.3138 14.8345 BLAminus -124.27, -172.21 51.21, 38.21 -66.01, -34.89 279.88, 56.74 -79.0, -36.67 out-na out 13.8446 Saltbr-na 999.0 HRD-in -63.82, -51.56 81.54, -17.95 na-out-out SNCaoo out-out ActLoopNT-out 7.486 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -155.41, 138.97 APE9-dihe-na 79.19, -161.1 APE8-dihe-in -86.3, 121.4 APE8-rot-in 298.93 APE67-dihe-out -108.87, 155.32 -65.67, 143.38 APE12-dist-out 19.5291 APE11-dist-out 23.0763 APE10-dist-out 20.7615 APE9-dist-out 18.856 None None MSE214,MSE271,MSE304,MSE319,MSE390,MSE394,MSE410,MSE412,MSE415 XRAY 1.8 0.164 0.211 A 290.0 271.0 0 26 26 0 [[220, 479]] 1.0 6cn9 Rattus norvegicus OTHER_WNK1_RAT WNK 2e-180 603.5 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 4Q2AA Q9JIH7 210 480 2126.0 No_ligand No_ligand Inactive DFGin 7.2137 13.7934 BLAminus -117.36, -164.82 49.65, 46.47 -77.52, -37.58 304.03, 158.37 -70.67, -36.24 out-na out 15.0764 Saltbr-na 999.0 HRD-in -68.5, -41.06 72.59, -50.88 na-out-out SNCaoo out-out ActLoopNT-out 6.8322 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -147.43, 135.39 APE9-dihe-na 75.2, -151.37 APE8-dihe-in -83.11, 121.94 APE8-rot-in 314.29 APE67-dihe-out -89.88, 131.67 -69.7, 135.61 APE12-dist-out 18.8226 APE11-dist-out 22.0153 APE10-dist-out 19.6279 APE9-dist-out 19.0062 S382A None None XRAY 3.5 0.248 0.297 A 287.0 271.0 0 26 26 0 [[220, 479]] 1.0 4q2a Rattus norvegicus OTHER_WNK1_RAT WNK 6.7e-180 601.8 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 6CN9B Q9JIH7 210 481 2126.0 No_ligand No_ligand Inactive DFGin 7.0852 13.8908 BLBminus -112.74, -169.93 57.97, 28.6 -64.91, 143.71 286.52, 173.49 86.76, -25.94 out-na out 15.0127 Saltbr-na 999.0 HRD-in -65.48, -53.87 84.25, -12.48 na-out-out SNCaoo out-out ActLoopNT-out 7.6706 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -147.45, 138.21 APE9-dihe-na 66.71, -149.88 APE8-dihe-in -81.4, 120.79 APE8-rot-in 297.11 APE67-dihe-out -99.84, 160.4 -67.18, 138.92 APE12-dist-out 18.5163 APE11-dist-out 20.8456 APE10-dist-out 18.4891 APE9-dist-out 18.6322 None None MSE214,MSE271,MSE304,MSE319,MSE390,MSE394,MSE410,MSE412,MSE415 XRAY 1.8 0.164 0.211 B 290.0 272.0 0 26 26 0 [[220, 479]] 1.0 6cn9 Rattus norvegicus OTHER_WNK1_RAT WNK 2e-180 603.5 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 7UOSA Q9JIH7 211 481 2126.0 WIB:501 Type1 Inactive DFGin 7.2674 14.3035 BLBminus -125.21, -174.97 61.07, 29.57 -60.09, 151.14 282.77, 77.42 85.21, -59.57 out-na out 14.4891 Saltbr-na 999.0 HRD-in -59.41, -55.29 70.63, -4.41 na-out-out SNCaoo out-out ActLoopNT-out 7.2166 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -149.7, 141.82 APE9-dihe-na 73.52, -151.65 APE8-dihe-in -80.74, 122.55 APE8-rot-in 302.14 APE67-dihe-out -111.2, 154.76 -64.51, 139.61 APE12-dist-out 18.9532 APE11-dist-out 22.2978 APE10-dist-out 19.7182 APE9-dist-out 18.367 S382A None None XRAY 2.9 0.229 0.295 A 290.0 271.0 0 26 26 0 [[220, 479]] 1.0 7uos Rattus norvegicus OTHER_WNK1_RAT WNK 7e-180 601.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 6OL2A Q9JIH7 203 481 2126.0 MU7:501 Type1.5_Back Inactive DFGin 7.2074 13.5552 BLBminus -106.4, -168.42 70.22, 20.5 -60.53, 125.05 299.67, 168.34 90.57, -13.99 out-na out 15.1769 Saltbr-na 999.0 HRD-in -67.61, -61.94 90.46, -11.61 na-out-out SNCaoo out-out ActLoopNT-out 7.4776 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -143.47, 141.48 APE9-dihe-na 75.2, -166.65 APE8-dihe-in -71.9, 129.22 APE8-rot-in 299.05 APE67-dihe-out -102.73, 153.59 -64.68, 139.68 APE12-dist-out 19.5412 APE11-dist-out 22.5956 APE10-dist-out 19.7741 APE9-dist-out 18.2599 S382A None None XRAY 2.1 0.205 0.268 A 290.0 279.0 0 26 26 0 [[220, 479]] 1.0 6ol2 Rattus norvegicus OTHER_WNK1_RAT WNK 7e-180 601.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 5W7TA Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.4172 15.9348 BLBtrans -104.69, 171.72 66.72, 19.42 -58.26, 129.69 184.83, 52.8 82.8, 3.34 out-na out 14.5394 Saltbr-na 999.0 HRD-in -71.27, -50.06 75.36, -9.98 na-out-out SNCaoo out-out ActLoopNT-out 8.5837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -87.54, -6.4 APE9-dihe-na 140.44, -174.25 APE8-dihe-in -100.52, 116.85 APE8-rot-in 301.69 APE67-dihe-in -56.05, -31.73 -45.94, -43.4 APE12-dist-out 14.8779 APE11-dist-in 11.5748 APE10-dist-out 12.3081 APE9-dist-in 5.4212 None SEP382 SEP382 XRAY 2.01 0.175 0.227 A 277.0 273.0 0 26 26 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 5W7TB Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.3857 15.245 BLBtrans -103.97, 173.91 64.08, 22.88 -61.0, 131.49 184.03, 62.56 90.07, -15.7 out-na out 14.1288 Saltbr-na 999.0 HRD-in -70.75, -51.57 74.83, -5.85 na-out-out SNCaoo out-out ActLoopNT-out 7.222 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -112.88, 5.47 APE9-dihe-na -140.59, -178.52 APE8-dihe-in -108.13, 115.32 APE8-rot-in 305.01 APE67-dihe-in -55.56, -28.14 -49.44, -36.46 APE12-dist-out 14.7107 APE11-dist-in 12.593 APE10-dist-in 7.8096 APE9-dist-in 4.793 None SEP382 SEP382 XRAY 2.01 0.175 0.227 B 277.0 273.0 0 26 26 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 5DRBA Q9JIH7 209 481 2126.0 5FJ:501 Type1.5_Front Inactive DFGin 6.4153 15.2426 BLBtrans -102.41, 174.78 66.6, 17.24 -54.98, 136.9 200.01, 54.53 87.03, -12.43 out-na out 15.6928 Saltbr-na 999.0 HRD-in -69.28, -52.98 81.61, -10.52 na-out-out SNCaoo out-out ActLoopNT-out 7.6084 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -157.99, 142.74 APE9-dihe-na 70.29, -166.96 APE8-dihe-in -67.0, 128.15 APE8-rot-out 148.06 APE67-dihe-out -98.12, 161.39 -68.79, 138.19 APE12-dist-out 18.3309 APE11-dist-out 21.6294 APE10-dist-out 19.4935 APE9-dist-out 17.6735 S382A None None XRAY 1.65 0.199 0.24 A 291.0 273.0 0 26 26 0 [[220, 479]] 1.0 5drb Rattus norvegicus OTHER_WNK1_RAT WNK 7.1e-180 601.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1

OTHER_WNK1 (Serine/threonine-protein kinase WNK1)

Total number of chains: 9
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 33.3% 6CN9A
DFGin BLBminus 3 33.3% 6CN9B
DFGin BLBtrans 3 33.3% 5DRBA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
WNK1 WNK1_RAT 9D3FA Q9JIH7 211 482 2126.0 No_ligand No_ligand Inactive DFGin 6.7872 13.9312 BLAminus -130.3, -171.09 52.28, 49.58 -77.43, -37.54 265.63, 179.36 -61.03, -48.02 out-na out 16.3912 Saltbr-na 999.0 HRD-in -67.67, -64.43 83.35, 3.34 na-out-out SNCaoo out-out ActLoopNT-out 6.6697 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.38 APE8-rot-none 999.0 APE67-dihe-out -124.38, -140.72 -73.34, 137.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.206 0.236 A 290.0 265.0 7 26 19 7 [[220, 479]] 1.0 9d3f Rattus norvegicus OTHER_WNK1_RAT WNK 5.1e-180 602.2 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 6CN9A Q9JIH7 210 480 2126.0 No_ligand No_ligand Inactive DFGin 7.3138 14.8345 BLAminus -124.27, -172.21 51.21, 38.21 -66.01, -34.89 279.88, 56.74 -79.0, -36.67 out-na out 13.8446 Saltbr-na 999.0 HRD-in -63.82, -51.56 81.54, -17.95 na-out-out SNCaoo out-out ActLoopNT-out 7.486 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -155.41, 138.97 APE9-dihe-na 79.19, -161.1 APE8-dihe-in -86.3, 121.4 APE8-rot-in 298.93 APE67-dihe-out -108.87, 155.32 -65.67, 143.38 APE12-dist-out 19.5291 APE11-dist-out 23.0763 APE10-dist-out 20.7615 APE9-dist-out 18.856 None None MSE214,MSE271,MSE304,MSE319,MSE390,MSE394,MSE410,MSE412,MSE415 XRAY 1.8 0.164 0.211 A 290.0 271.0 0 26 26 0 [[220, 479]] 1.0 6cn9 Rattus norvegicus OTHER_WNK1_RAT WNK 2e-180 603.5 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 4Q2AA Q9JIH7 210 480 2126.0 No_ligand No_ligand Inactive DFGin 7.2137 13.7934 BLAminus -117.36, -164.82 49.65, 46.47 -77.52, -37.58 304.03, 158.37 -70.67, -36.24 out-na out 15.0764 Saltbr-na 999.0 HRD-in -68.5, -41.06 72.59, -50.88 na-out-out SNCaoo out-out ActLoopNT-out 6.8322 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -147.43, 135.39 APE9-dihe-na 75.2, -151.37 APE8-dihe-in -83.11, 121.94 APE8-rot-in 314.29 APE67-dihe-out -89.88, 131.67 -69.7, 135.61 APE12-dist-out 18.8226 APE11-dist-out 22.0153 APE10-dist-out 19.6279 APE9-dist-out 19.0062 S382A None None XRAY 3.5 0.248 0.297 A 287.0 271.0 0 26 26 0 [[220, 479]] 1.0 4q2a Rattus norvegicus OTHER_WNK1_RAT WNK 6.7e-180 601.8 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 6CN9B Q9JIH7 210 481 2126.0 No_ligand No_ligand Inactive DFGin 7.0852 13.8908 BLBminus -112.74, -169.93 57.97, 28.6 -64.91, 143.71 286.52, 173.49 86.76, -25.94 out-na out 15.0127 Saltbr-na 999.0 HRD-in -65.48, -53.87 84.25, -12.48 na-out-out SNCaoo out-out ActLoopNT-out 7.6706 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -147.45, 138.21 APE9-dihe-na 66.71, -149.88 APE8-dihe-in -81.4, 120.79 APE8-rot-in 297.11 APE67-dihe-out -99.84, 160.4 -67.18, 138.92 APE12-dist-out 18.5163 APE11-dist-out 20.8456 APE10-dist-out 18.4891 APE9-dist-out 18.6322 None None MSE214,MSE271,MSE304,MSE319,MSE390,MSE394,MSE410,MSE412,MSE415 XRAY 1.8 0.164 0.211 B 290.0 272.0 0 26 26 0 [[220, 479]] 1.0 6cn9 Rattus norvegicus OTHER_WNK1_RAT WNK 2e-180 603.5 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 7UOSA Q9JIH7 211 481 2126.0 WIB:501 Type1 Inactive DFGin 7.2674 14.3035 BLBminus -125.21, -174.97 61.07, 29.57 -60.09, 151.14 282.77, 77.42 85.21, -59.57 out-na out 14.4891 Saltbr-na 999.0 HRD-in -59.41, -55.29 70.63, -4.41 na-out-out SNCaoo out-out ActLoopNT-out 7.2166 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -149.7, 141.82 APE9-dihe-na 73.52, -151.65 APE8-dihe-in -80.74, 122.55 APE8-rot-in 302.14 APE67-dihe-out -111.2, 154.76 -64.51, 139.61 APE12-dist-out 18.9532 APE11-dist-out 22.2978 APE10-dist-out 19.7182 APE9-dist-out 18.367 S382A None None XRAY 2.9 0.229 0.295 A 290.0 271.0 0 26 26 0 [[220, 479]] 1.0 7uos Rattus norvegicus OTHER_WNK1_RAT WNK 7e-180 601.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 6OL2A Q9JIH7 203 481 2126.0 MU7:501 Type1.5_Back Inactive DFGin 7.2074 13.5552 BLBminus -106.4, -168.42 70.22, 20.5 -60.53, 125.05 299.67, 168.34 90.57, -13.99 out-na out 15.1769 Saltbr-na 999.0 HRD-in -67.61, -61.94 90.46, -11.61 na-out-out SNCaoo out-out ActLoopNT-out 7.4776 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -143.47, 141.48 APE9-dihe-na 75.2, -166.65 APE8-dihe-in -71.9, 129.22 APE8-rot-in 299.05 APE67-dihe-out -102.73, 153.59 -64.68, 139.68 APE12-dist-out 19.5412 APE11-dist-out 22.5956 APE10-dist-out 19.7741 APE9-dist-out 18.2599 S382A None None XRAY 2.1 0.205 0.268 A 290.0 279.0 0 26 26 0 [[220, 479]] 1.0 6ol2 Rattus norvegicus OTHER_WNK1_RAT WNK 7e-180 601.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 5W7TA Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.4172 15.9348 BLBtrans -104.69, 171.72 66.72, 19.42 -58.26, 129.69 184.83, 52.8 82.8, 3.34 out-na out 14.5394 Saltbr-na 999.0 HRD-in -71.27, -50.06 75.36, -9.98 na-out-out SNCaoo out-out ActLoopNT-out 8.5837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -87.54, -6.4 APE9-dihe-na 140.44, -174.25 APE8-dihe-in -100.52, 116.85 APE8-rot-in 301.69 APE67-dihe-in -56.05, -31.73 -45.94, -43.4 APE12-dist-out 14.8779 APE11-dist-in 11.5748 APE10-dist-out 12.3081 APE9-dist-in 5.4212 None SEP382 SEP382 XRAY 2.01 0.175 0.227 A 277.0 273.0 0 26 26 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 5W7TB Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.3857 15.245 BLBtrans -103.97, 173.91 64.08, 22.88 -61.0, 131.49 184.03, 62.56 90.07, -15.7 out-na out 14.1288 Saltbr-na 999.0 HRD-in -70.75, -51.57 74.83, -5.85 na-out-out SNCaoo out-out ActLoopNT-out 7.222 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -112.88, 5.47 APE9-dihe-na -140.59, -178.52 APE8-dihe-in -108.13, 115.32 APE8-rot-in 305.01 APE67-dihe-in -55.56, -28.14 -49.44, -36.46 APE12-dist-out 14.7107 APE11-dist-in 12.593 APE10-dist-in 7.8096 APE9-dist-in 4.793 None SEP382 SEP382 XRAY 2.01 0.175 0.227 B 277.0 273.0 0 26 26 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
WNK1 WNK1_RAT 5DRBA Q9JIH7 209 481 2126.0 5FJ:501 Type1.5_Front Inactive DFGin 6.4153 15.2426 BLBtrans -102.41, 174.78 66.6, 17.24 -54.98, 136.9 200.01, 54.53 87.03, -12.43 out-na out 15.6928 Saltbr-na 999.0 HRD-in -69.28, -52.98 81.61, -10.52 na-out-out SNCaoo out-out ActLoopNT-out 7.6084 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -157.99, 142.74 APE9-dihe-na 70.29, -166.96 APE8-dihe-in -67.0, 128.15 APE8-rot-out 148.06 APE67-dihe-out -98.12, 161.39 -68.79, 138.19 APE12-dist-out 18.3309 APE11-dist-out 21.6294 APE10-dist-out 19.4935 APE9-dist-out 17.6735 S382A None None XRAY 1.65 0.199 0.24 A 291.0 273.0 0 26 26 0 [[220, 479]] 1.0 5drb Rattus norvegicus OTHER_WNK1_RAT WNK 7.1e-180 601.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1