AGC_RPS6KA3-1 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 26
Active chains: 2
Uniprot: KS6A3_HUMAN
Kinase Domain Residues: 68 - 327
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 16 61.5% 4NUSA
DFGin None 4 15.4% 7OPOA
DFGin ABAminus 2 7.7% 4NW6A
DFGin BLAminus 2 7.7% AF-P51812-K1A
DFGinter None 2 7.7% 7OPOG
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P51812-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 335 0 None None Ribosomal protein S6 kinase alpha-3
AF-P51812-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 335 0 None None Ribosomal protein S6 kinase alpha-3
4NW5A 1.94 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2NR Type1 51 - 359 0 None None Ribosomal protein S6 kinase alpha-3
4NW6A 1.74 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2NS Type1 51 - 359 0 None None Ribosomal protein S6 kinase alpha-3
7OPOA 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 45 - 348 0 None None Ribosomal protein S6 kinase alpha-3
7OPOE 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
7OPOI 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_onnn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
7OPOK 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
7OPOC 2.75 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 46 - 347 0 None None Ribosomal protein S6 kinase alpha-3
7OPOG 2.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanni APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
8EQ5A 1.8 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iioo QCT Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3
8R58A 2.31 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nioo QCT Type1 49 - 348 0 None None Ribosomal protein S6 kinase alpha-3
8XFYA 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 58 - 358 0 None None Ribosomal protein S6 kinase alpha-3
8XFYB 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 59 - 358 0 None None Ribosomal protein S6 kinase alpha-3
8XFYC 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 61 - 358 0 None None Ribosomal protein S6 kinase alpha-3
8XFYD 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3
8XFYE 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 64 - 348 0 None None Ribosomal protein S6 kinase alpha-3
8XFYF 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 345 0 None None Ribosomal protein S6 kinase alpha-3
8XFYG 3.2 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 59 - 346 0 None None Ribosomal protein S6 kinase alpha-3
8XFYH 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 59 - 348 0 None None Ribosomal protein S6 kinase alpha-3
8XFYI 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3
8XFYJ 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 65 - 347 0 None None Ribosomal protein S6 kinase alpha-3
4NUSA 2.39 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_iooi 2NK Type1 53 - 359 0 None None Ribosomal protein S6 kinase alpha-3
5D9LA 2.15 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nnno 583 Type1 49 - 359 0 None None Ribosomal protein S6 kinase alpha-3
5D9KA 2.55 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nnoi 584 Type1 62 - 359 0 None None Ribosomal protein S6 kinase alpha-3
5D9KB 2.55 Inactive DFGout‑None in-none out-out nonTYR APEdihe_aaiii APEdist_nnoi 584 Type1 62 - 359 0 None None Ribosomal protein S6 kinase alpha-3

AGC_RPS6KA3-1 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 30
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 19 63.3% 4NUSA
DFGin None 5 16.7% 7OPOA
DFGin ABAminus 2 6.7% 4NW6A
DFGin BLAminus 2 6.7% AF-P51812-K1A
DFGinter None 2 6.7% 7OPOG
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
KS6A3_HUMAN AF-P51812-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 335 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN AF-P51812-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 60 - 335 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 4NW5A 1.94 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2NR Type1 51 - 359 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 4NW6A 1.74 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2NS Type1 51 - 359 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 7OPOA 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 45 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 7OPOE 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 7OPOI 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_onnn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 7OPOK 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 7OPOC 2.75 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 46 - 347 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 7OPOG 2.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanni APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8EQ5A 1.8 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iioo QCT Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8R58A 2.31 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nioo QCT Type1 49 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8XFYA 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 58 - 358 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8XFYB 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 59 - 358 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8XFYC 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 61 - 358 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8XFYD 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8XFYE 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 64 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8XFYF 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 345 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8XFYG 3.2 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 59 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8XFYH 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 59 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8XFYI 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 8XFYJ 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 65 - 347 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 4NUSA 2.39 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_iooi 2NK Type1 53 - 359 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 5D9LA 2.15 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nnno 583 Type1 49 - 359 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 5D9KA 2.55 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nnoi 584 Type1 62 - 359 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_HUMAN 5D9KB 2.55 Inactive DFGout‑None in-none out-out nonTYR APEdihe_aaiii APEdist_nnoi 584 Type1 62 - 359 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
KS6A3_MOUSE 3G51A 1.8 Inactive DFGin‑None none-none out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 47 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
KS6A3_MOUSE 3UBDA 1.53 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iioo SL0 Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
KS6A3_MOUSE 4EL9A 1.55 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_oioo AFE Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
KS6A3_MOUSE 4GUEA 1.8 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_oioo QCT Type1 48 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus

AGC_RPS6KA3-1 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 4
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 3 75.0% 4EL9A
DFGin None 1 25.0% 3G51A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
KS6A3_MOUSE 3G51A 1.8 Inactive DFGin‑None none-none out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 47 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
KS6A3_MOUSE 3UBDA 1.53 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iioo SL0 Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
KS6A3_MOUSE 4EL9A 1.55 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_oioo AFE Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
KS6A3_MOUSE 4GUEA 1.8 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_oioo QCT Type1 48 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus