AGC_RPS6KA3-1 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 26
Active chains: 2
Family: AGC
Uniprot: KS6A3_HUMAN
Kinase Domain Residues: 68 - 327
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 16 61.5% 4NUSA
DFGin None 4 15.4% 7OPOA
DFGin ABAminus 2 7.7% 4NW6A
DFGin BLAminus 2 7.7% AF-P51812-K1A
DFGinter None 2 7.7% 7OPOG
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P51812-K1A 60 335 740.0 No_ligand No_ligand Active DFGin 6.764 14.365 BLAminus -128.08, -168.93 44.14, 64.08 -76.47, 13.22 289.9, 79.47 -63.08, -17.42 in-in in 8.864 Saltbr-in 2.673 HRD-in -82.22, -48.58 63.74, 10.13 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.28, 165.34 APE9-dihe-na 113.22, 171.27 APE8-dihe-in -72.62, 129.88 APE8-rot-in 293.52 APE67-dihe-in -60.98, -26.44 -58.38, -41.01 APE12-dist-in 8.476 APE11-dist-in 11.414 APE10-dist-in 5.681 APE9-dist-in 3.536 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K1 AGC_RPS6KA3-1_HUMAN AGC 1.5e-97 331.7 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AF-P51812-K3A 60 335 740.0 No_ligand No_ligand Active DFGin 6.499 14.162 BLAminus -131.58, -177.03 51.85, 64.94 -73.26, 9.93 296.53, 86.04 -63.15, -12.88 in-in in 8.786 Saltbr-in 2.627 HRD-in -83.1, -49.32 68.04, 9.8 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.96, 166.11 APE9-dihe-na 108.7, 179.24 APE8-dihe-in -85.77, 132.92 APE8-rot-in 303.81 APE67-dihe-in -62.2, -27.77 -65.91, -38.69 APE12-dist-in 8.389 APE11-dist-in 11.43 APE10-dist-in 5.673 APE9-dist-in 3.362 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K3 AGC_RPS6KA3-1_HUMAN AGC 1.5e-97 331.7 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
4NW5A 51 359 740.0 2NR:1001 Type1 Inactive DFGin 6.865 13.918 ABAminus -125.07, -26.39 -111.82, 108.74 -107.62, 13.77 297.76, 84.36 -56.94, -37.48 in-in in 8.623 Saltbr-in 2.802 HRD-in -66.66, -50.7 69.74, -28.95 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.85, 144.89 APE9-dihe-na 119.11, -176.62 APE8-dihe-in -86.28, 123.64 APE8-rot-in 295.84 APE67-dihe-in -53.89, -25.82 -50.24, -49.0 APE12-dist-in 8.135 APE11-dist-in 11.049 APE10-dist-in 5.31 APE9-dist-in 4.808 None None None XRAY 1.94 0.175 0.219 A 323 302 0 0 0 0 [[68, 327], [422, 679]] 2.0 4nw5 AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
4NW6A 51 359 740.0 2NS:1001 Type1 Inactive DFGin 6.782 13.904 ABAminus -124.66, -15.73 -125.39, 119.67 -114.93, 13.33 295.12, 83.78 -57.16, -34.75 in-in in 8.561 Saltbr-in 2.835 HRD-in -67.61, -47.75 68.59, -32.24 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.14, 147.51 APE9-dihe-na 118.99, -176.28 APE8-dihe-in -85.82, 124.26 APE8-rot-in 292.93 APE67-dihe-in -54.12, -25.71 -51.61, -49.13 APE12-dist-in 8.074 APE11-dist-in 10.959 APE10-dist-in 5.215 APE9-dist-in 4.928 None None None XRAY 1.74 0.167 0.201 A 323 302 0 0 0 0 [[68, 327], [422, 679]] 2.0 4nw6 AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
7OPOA 45 348 740.0 ANP:401 ATPlike Inactive DFGin 5.64 11.283 None -75.51, -9.72 -147.12, 169.74 -135.13, 44.64 43.61, 79.33 88.97, 14.8 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.31, -36.27 72.22, -63.18 none-out-out SNCnoo out-out ActLoopNT-out 10.019 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.25 APE8-rot-out 57.51 APE67-dihe-in -58.48, -32.95 -79.53, -17.69 APE12-dist-out 16.181 APE11-dist-out 18.834 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 A 317 295 9 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
7OPOE 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.828 11.217 None -75.62, -9.94 -146.57, 168.73 -137.15, 44.22 42.0, 80.75 88.39, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.39, -31.42 74.68, -62.95 none-out-out SNCnoo out-out ActLoopNT-out 10.132 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.55 APE8-rot-out 177.27 APE67-dihe-in -61.67, -34.26 -80.52, -22.56 APE12-dist-out 16.151 APE11-dist-out 17.693 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 E 317 293 10 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
7OPOI 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.742 11.315 None -74.55, -8.16 -143.05, 166.95 -136.59, 41.95 46.16, 81.46 88.21, 13.52 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.43, -31.99 74.45, -63.8 none-out-out SNCnoo out-out ActLoopNT-out 10.224 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.34 APE8-rot-out 174.05 APE67-dihe-in -60.03, -34.02 -108.65, -14.12 APE12-dist-out 16.688 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 I 317 292 11 0 0 3 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
7OPOK 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.743 11.055 None -76.12, -10.81 -146.65, 168.53 -136.2, 45.6 41.69, 77.26 88.29, 15.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -32.34 73.01, -61.24 none-out-out SNCnoo out-out ActLoopNT-out 9.952 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 7.45 APE8-rot-out 57.97 APE67-dihe-in -59.53, -34.14 -77.79, -20.27 APE12-dist-out 17.117 APE11-dist-out 17.377 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 K 317 293 10 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
7OPOC 46 347 740.0 ANP:401 ATPlike Inactive DFGinter 5.815 10.993 None -75.13, -10.43 -146.35, 169.25 -135.79, 44.23 43.29, 81.79 87.07, 14.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.74, -32.6 74.07, -63.87 none-out-out SNCnoo out-out ActLoopNT-out 10.165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.13, 122.89 APE9-dihe-na 75.62, 166.95 APE8-dihe-in -113.03, 115.92 APE8-rot-out 46.3 APE67-dihe-in -62.7, -36.2 -57.15, -32.55 APE12-dist-out 16.312 APE11-dist-out 16.934 APE10-dist-out 13.494 APE9-dist-out 6.87 None None None XRAY 2.75 0.209 0.232 C 317 295 7 0 0 0 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
7OPOG 46 348 740.0 ANP:401 ATPlike Inactive DFGinter 6.68 10.963 None -75.68, -10.29 -146.32, 168.68 -137.91, 45.72 44.25, 84.07 86.95, 15.93 out-out out 19.338 Saltbr-out 19.753 HRD-in -66.3, -31.74 74.35, -64.56 out-out-out SNCooo out-out ActLoopNT-out 10.112 ActLoopCT-out nonTYR APEdihe_aanni APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.02 APE8-rot-none 999.0 APE67-dihe-in -58.75, -33.49 -86.55, -15.46 APE12-dist-out 16.986 APE11-dist-out 17.767 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 G 317 301 2 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8EQ5A 49 346 740.0 QCT:401 Type1 Inactive DFGout 22.266 9.787 None -73.88, 137.17 -86.9, 13.11 -125.85, 163.49 50.35, 92.47 -96.22, 152.3 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.97, -41.58 76.84, -49.89 none-out-out SNCnoo out-out ActLoopNT-out 15.409 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -123.13, 112.05 APE9-dihe-na -120.61, 174.84 APE8-dihe-in -88.65, 114.78 APE8-rot-in 305.94 APE67-dihe-in -62.47, -20.15 -62.23, -32.4 APE12-dist-in 13.883 APE11-dist-in 11.461 APE10-dist-out 9.67 APE9-dist-out 7.056 None None None XRAY 1.8 0.185 0.225 A 305 289 9 0 0 2 [[68, 327], [422, 679]] 2.0 8eq5 AGC_RPS6KA3-1_HUMAN AGC 2.1e-97 331.2 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8R58A 49 348 740.0 QCT:401 Type1 Inactive DFGout 22.723 9.734 None -69.6, 133.49 -81.98, 4.89 -117.98, 155.18 46.12, 100.26 -81.19, 145.71 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.36, -38.11 64.12, -42.77 none-out-out SNCnoo out-out ActLoopNT-out 15.002 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -64.62, 110.24 APE9-dihe-na -140.48, 179.06 APE8-dihe-in -91.85, 110.78 APE8-rot-in 305.36 APE67-dihe-in -59.58, -23.45 -59.81, -33.88 APE12-dist-none 999.0 APE11-dist-in 11.825 APE10-dist-out 8.908 APE9-dist-out 7.055 None None None XRAY 2.31 0.238 0.263 A 317 282 18 0 0 11 [[68, 327], [422, 679]] 2.0 8r58 AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8XFYA 58 358 740.0 A1LU8:401 Type1 Inactive DFGout 13.205 7.347 None -84.69, 175.04 -98.49, -2.97 -56.06, -41.49 288.51, 111.93 -88.04, -1.58 out-out out 13.584 Saltbr-out 12.491 HRD-out -102.98, 108.87 -62.66, -66.03 out-out-out SNCooo out-out ActLoopNT-out 5.29 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -171.34, 174.53 APE9-dihe-na 132.9, 150.52 APE8-dihe-in -54.44, 119.7 APE8-rot-in 325.6 APE67-dihe-in -67.51, -35.24 -72.39, -24.23 APE12-dist-none 999.0 APE11-dist-out 15.301 APE10-dist-out 13.362 APE9-dist-out 6.397 None None None XRAY 3.2 0.233 0.303 A 320 289 12 0 0 9 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8XFYB 59 358 740.0 A1LU8:401 Type1 Inactive DFGout 12.476 7.622 None -79.21, 172.69 -104.74, 14.38 -72.96, -37.65 288.72, 121.74 -83.1, -14.53 out-out out 13.02 Saltbr-out 10.251 HRD-out -85.11, 105.26 -64.66, -55.07 out-out-out SNCooo out-out ActLoopNT-out 5.181 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -141.21, 158.45 APE9-dihe-na 119.59, 160.83 APE8-dihe-in -64.8, 132.56 APE8-rot-out 38.16 APE67-dihe-in -76.3, -33.52 -81.38, -10.91 APE12-dist-none 999.0 APE11-dist-out 15.912 APE10-dist-out 12.427 APE9-dist-out 6.369 None None None XRAY 3.2 0.233 0.303 B 320 277 23 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8XFYC 61 358 740.0 A1LU8:401 Type1 Inactive DFGout 13.007 7.405 None -74.08, -176.12 -117.42, 16.75 -70.92, -31.59 288.86, 115.13 -89.42, -33.94 none-none none 999.0 Saltbr-none 999.0 HRD-out -99.11, 116.77 -79.3, -60.22 none-out-out SNCnoo out-out ActLoopNT-out 5.139 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -154.86, 91.8 APE9-dihe-na -163.03, 159.53 APE8-dihe-in -69.77, 116.03 APE8-rot-in 309.84 APE67-dihe-in -63.05, -25.35 -70.36, -29.8 APE12-dist-none 999.0 APE11-dist-out 15.692 APE10-dist-out 13.257 APE9-dist-out 6.185 None None None XRAY 3.2 0.233 0.303 C 320 272 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8XFYD 63 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.68 7.718 None -85.23, 171.03 -99.91, 5.18 -66.56, -47.9 288.97, 119.73 -68.87, -42.49 none-none none 999.0 Saltbr-none 999.0 HRD-out -108.97, 107.04 -79.62, 147.57 none-out-out SNCnoo out-out ActLoopNT-out 5.004 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -160.66, -177.37 APE9-dihe-na 101.82, 157.81 APE8-dihe-in -62.84, 132.59 APE8-rot-out 47.92 APE67-dihe-in -68.43, -26.54 -77.35, -22.1 APE12-dist-none 999.0 APE11-dist-out 16.005 APE10-dist-out 13.641 APE9-dist-out 7.28 None None None XRAY 3.2 0.233 0.303 D 320 260 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8XFYE 64 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.814 7.732 None -79.79, 173.69 -104.44, 5.05 -67.56, -37.65 296.33, 117.93 -76.73, -31.97 none-none none 999.0 Saltbr-none 999.0 HRD-out -107.95, 111.24 -79.69, -31.85 none-out-out SNCnoo out-out ActLoopNT-out 5.217 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -171.13, 156.06 APE9-dihe-na 118.15, 155.77 APE8-dihe-in -55.33, 128.86 APE8-rot-out 36.52 APE67-dihe-in -70.55, -22.72 -79.46, -18.88 APE12-dist-none 999.0 APE11-dist-out 16.556 APE10-dist-out 12.762 APE9-dist-in 5.579 None None None XRAY 3.2 0.233 0.303 E 320 261 24 0 0 9 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8XFYF 63 345 740.0 A1LU8:401 Type1 Inactive DFGout 12.743 7.471 None -95.59, -178.42 -108.18, 9.34 -70.41, -40.72 293.14, 115.72 -77.9, -28.8 none-none none 999.0 Saltbr-none 999.0 HRD-out -100.4, 115.65 -68.34, -48.2 none-out-out SNCnoo out-out ActLoopNT-out 5.156 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -160.1, 173.9 APE9-dihe-na 114.4, 160.81 APE8-dihe-in -56.13, 119.9 APE8-rot-out 41.37 APE67-dihe-in -71.03, -16.28 -73.87, -18.19 APE12-dist-none 999.0 APE11-dist-out 15.392 APE10-dist-out 13.539 APE9-dist-out 6.404 None None None XRAY 3.2 0.233 0.303 F 320 255 28 0 0 11 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8XFYG 59 346 740.0 A1LU8:401 Type1 Inactive DFGout 12.937 7.226 None -78.16, 176.02 -98.19, 0.09 -62.25, -40.75 291.8, 111.06 -81.64, -19.61 in-out in 7.881 Saltbr-out 5.486 HRD-out -91.07, 110.45 -88.21, -3.19 out-out-out SNCooo out-out ActLoopNT-out 5.164 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -71.01, 158.33 APE9-dihe-na 129.65, 145.56 APE8-dihe-in -72.78, 126.88 APE8-rot-in 303.8 APE67-dihe-in -65.24, -40.51 -67.91, -29.47 APE12-dist-none 999.0 APE11-dist-out 16.145 APE10-dist-out 12.069 APE9-dist-in 4.644 None None None XRAY 3.2 0.233 0.303 G 320 276 12 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8XFYH 59 348 740.0 A1LU8:401 Type1 Inactive DFGout 13.374 7.713 None -77.26, -179.45 -100.74, 0.21 -62.05, -41.28 291.33, 112.54 -80.3, -18.96 out-out out 12.403 Saltbr-out 7.869 HRD-out -114.7, 107.73 -80.32, -3.28 out-out-out SNCooo out-out ActLoopNT-out 5.561 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -169.14, 166.07 APE9-dihe-na 97.31, 158.5 APE8-dihe-in -62.25, 138.33 APE8-rot-out 53.1 APE67-dihe-in -70.31, -30.08 -88.76, -15.85 APE12-dist-none 999.0 APE11-dist-out 15.688 APE10-dist-out 12.169 APE9-dist-in 5.119 None None None XRAY 3.2 0.233 0.303 H 320 277 13 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8XFYI 63 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.485 7.394 None -79.8, 178.19 -107.54, 4.76 -62.98, -39.18 294.19, 109.04 -76.4, -38.16 none-none none 999.0 Saltbr-none 999.0 HRD-out -110.77, 98.18 -69.66, 134.16 none-out-out SNCnoo out-out ActLoopNT-out 4.941 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -128.64, 168.96 APE9-dihe-na 103.76, 142.33 APE8-dihe-in -52.02, 130.9 APE8-rot-out 52.96 APE67-dihe-in -63.86, -32.68 -78.41, -20.46 APE12-dist-none 999.0 APE11-dist-out 16.546 APE10-dist-out 12.606 APE9-dist-out 6.609 None None None XRAY 3.2 0.233 0.303 I 320 260 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
8XFYJ 65 347 740.0 A1LU8:401 Type1 Inactive DFGout 12.681 7.253 None -82.1, 175.26 -103.79, -3.59 -58.74, -48.51 291.22, 109.94 -83.23, -7.51 none-none none 999.0 Saltbr-none 999.0 HRD-out -111.91, 105.75 -75.45, -19.05 none-out-out SNCnoo out-out ActLoopNT-out 5.003 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -112.59, 166.79 APE9-dihe-na 114.55, 148.33 APE8-dihe-in -68.28, 140.99 APE8-rot-in 305.08 APE67-dihe-in -73.95, -40.89 -90.2, -12.76 APE12-dist-none 999.0 APE11-dist-out 16.562 APE10-dist-out 12.863 APE9-dist-in 5.003 None None None XRAY 3.2 0.233 0.303 J 320 257 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
4NUSA 53 359 740.0 2NK:1001 Type1 Inactive DFGout 13.045 7.342 None -78.78, 166.95 -80.65, -18.82 -46.42, -28.2 293.03, 106.08 -107.82, 1.09 in-out in 9.447 Saltbr-out 3.913 HRD-out -114.59, 104.74 -76.23, -8.33 out-out-out SNCooo out-out ActLoopNT-out 5.209 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.74, 153.82 APE9-dihe-na 111.28, -177.73 APE8-dihe-in -92.12, 117.05 APE8-rot-in 306.83 APE67-dihe-in -54.85, -26.24 -45.49, -49.89 APE12-dist-in 13.431 APE11-dist-out 16.163 APE10-dist-out 10.59 APE9-dist-in 4.083 None None None XRAY 2.39 0.191 0.231 A 323 301 0 0 0 0 [[68, 327], [422, 679]] 2.0 4nus AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
5D9LA 49 359 740.0 583:1001 Type1 Inactive DFGout 13.125 7.071 None -75.24, 167.74 -87.99, -6.69 -50.57, -47.91 290.28, 116.72 -91.68, 11.14 in-out in 8.137 Saltbr-out 7.416 HRD-out -120.21, 105.54 -83.41, 126.5 out-out-out SNCooo out-out ActLoopNT-out 5.263 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.74 APE8-dihe-in -60.19, 116.14 APE8-rot-in 302.87 APE67-dihe-in -59.28, -26.44 -61.48, -36.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.864 None None None XRAY 2.15 0.168 0.224 A 323 299 12 0 0 12 [[68, 327], [422, 679]] 2.0 5d9l AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
5D9KA 62 359 740.0 584:401 Type1 Inactive DFGout 12.972 7.703 None -70.85, 175.06 -99.81, -5.69 -54.85, -40.91 296.9, 103.08 -90.51, 7.61 in-out in 9.757 Saltbr-out 5.95 HRD-out -115.19, 98.47 -57.55, -41.76 out-out-out SNCooo out-out ActLoopNT-out 4.895 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 132.75 APE9-dihe-na 132.11, 175.33 APE8-dihe-in -91.17, 111.44 APE8-rot-in 313.37 APE67-dihe-in -60.35, -22.61 -61.26, -30.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.938 APE9-dist-in 5.828 None None None XRAY 2.55 0.183 0.227 A 330 280 12 0 0 12 [[68, 327], [422, 679]] 2.0 5d9k AGC_RPS6KA3-1_HUMAN AGC 2.8e-97 330.8 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
5D9KB 62 359 740.0 584:401 Type1 Inactive DFGout 12.94 7.705 None -71.4, 176.28 -100.1, -5.4 -52.09, -44.72 291.08, 99.76 -90.94, 9.31 in-none in 9.81 Saltbr-none 999.0 HRD-out -114.53, 98.39 -57.41, -41.87 none-out-out SNCnoo out-out ActLoopNT-out 5.428 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 137.48 APE9-dihe-na 131.93, 176.62 APE8-dihe-in -91.59, 110.99 APE8-rot-in 314.15 APE67-dihe-in -59.51, -22.8 -61.13, -31.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.286 APE9-dist-in 5.876 None None None XRAY 2.55 0.183 0.227 B 330 280 11 0 0 11 [[68, 327], [422, 679]] 2.0 5d9k AGC_RPS6KA3-1_HUMAN AGC 2.8e-97 330.8 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3

AGC_RPS6KA3-1 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 30
Active chains: 2
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 19 63.3% 4NUSA
DFGin None 5 16.7% 7OPOA
DFGin ABAminus 2 6.7% 4NW6A
DFGin BLAminus 2 6.7% AF-P51812-K1A
DFGinter None 2 6.7% 7OPOG
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
KS6A3_HUMAN AF-P51812-K1A P51812 60 335 740.0 No_ligand No_ligand Active DFGin 6.764 14.365 BLAminus -128.08, -168.93 44.14, 64.08 -76.47, 13.22 289.9, 79.47 -63.08, -17.42 in-in in 8.864 Saltbr-in 2.673 HRD-in -82.22, -48.58 63.74, 10.13 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.28, 165.34 APE9-dihe-na 113.22, 171.27 APE8-dihe-in -72.62, 129.88 APE8-rot-in 293.52 APE67-dihe-in -60.98, -26.44 -58.38, -41.01 APE12-dist-in 8.476 APE11-dist-in 11.414 APE10-dist-in 5.681 APE9-dist-in 3.536 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K1 Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 1.5e-97 331.7 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN AF-P51812-K3A P51812 60 335 740.0 No_ligand No_ligand Active DFGin 6.499 14.162 BLAminus -131.58, -177.03 51.85, 64.94 -73.26, 9.93 296.53, 86.04 -63.15, -12.88 in-in in 8.786 Saltbr-in 2.627 HRD-in -83.1, -49.32 68.04, 9.8 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.96, 166.11 APE9-dihe-na 108.7, 179.24 APE8-dihe-in -85.77, 132.92 APE8-rot-in 303.81 APE67-dihe-in -62.2, -27.77 -65.91, -38.69 APE12-dist-in 8.389 APE11-dist-in 11.43 APE10-dist-in 5.673 APE9-dist-in 3.362 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K3 Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 1.5e-97 331.7 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 4NW5A P51812 51 359 740.0 2NR:1001 Type1 Inactive DFGin 6.865 13.918 ABAminus -125.07, -26.39 -111.82, 108.74 -107.62, 13.77 297.76, 84.36 -56.94, -37.48 in-in in 8.623 Saltbr-in 2.802 HRD-in -66.66, -50.7 69.74, -28.95 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.85, 144.89 APE9-dihe-na 119.11, -176.62 APE8-dihe-in -86.28, 123.64 APE8-rot-in 295.84 APE67-dihe-in -53.89, -25.82 -50.24, -49.0 APE12-dist-in 8.135 APE11-dist-in 11.049 APE10-dist-in 5.31 APE9-dist-in 4.808 None None None XRAY 1.94 0.175 0.219 A 323 302 0 0 0 0 [[68, 327], [422, 679]] 2.0 4nw5 Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 4NW6A P51812 51 359 740.0 2NS:1001 Type1 Inactive DFGin 6.782 13.904 ABAminus -124.66, -15.73 -125.39, 119.67 -114.93, 13.33 295.12, 83.78 -57.16, -34.75 in-in in 8.561 Saltbr-in 2.835 HRD-in -67.61, -47.75 68.59, -32.24 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.14, 147.51 APE9-dihe-na 118.99, -176.28 APE8-dihe-in -85.82, 124.26 APE8-rot-in 292.93 APE67-dihe-in -54.12, -25.71 -51.61, -49.13 APE12-dist-in 8.074 APE11-dist-in 10.959 APE10-dist-in 5.215 APE9-dist-in 4.928 None None None XRAY 1.74 0.167 0.201 A 323 302 0 0 0 0 [[68, 327], [422, 679]] 2.0 4nw6 Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 7OPOA P51812 45 348 740.0 ANP:401 ATPlike Inactive DFGin 5.64 11.283 None -75.51, -9.72 -147.12, 169.74 -135.13, 44.64 43.61, 79.33 88.97, 14.8 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.31, -36.27 72.22, -63.18 none-out-out SNCnoo out-out ActLoopNT-out 10.019 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.25 APE8-rot-out 57.51 APE67-dihe-in -58.48, -32.95 -79.53, -17.69 APE12-dist-out 16.181 APE11-dist-out 18.834 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 A 317 295 9 0 0 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 7OPOE P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.828 11.217 None -75.62, -9.94 -146.57, 168.73 -137.15, 44.22 42.0, 80.75 88.39, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.39, -31.42 74.68, -62.95 none-out-out SNCnoo out-out ActLoopNT-out 10.132 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.55 APE8-rot-out 177.27 APE67-dihe-in -61.67, -34.26 -80.52, -22.56 APE12-dist-out 16.151 APE11-dist-out 17.693 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 E 317 293 10 0 0 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 7OPOI P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.742 11.315 None -74.55, -8.16 -143.05, 166.95 -136.59, 41.95 46.16, 81.46 88.21, 13.52 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.43, -31.99 74.45, -63.8 none-out-out SNCnoo out-out ActLoopNT-out 10.224 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.34 APE8-rot-out 174.05 APE67-dihe-in -60.03, -34.02 -108.65, -14.12 APE12-dist-out 16.688 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 I 317 292 11 0 0 3 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 7OPOK P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.743 11.055 None -76.12, -10.81 -146.65, 168.53 -136.2, 45.6 41.69, 77.26 88.29, 15.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -32.34 73.01, -61.24 none-out-out SNCnoo out-out ActLoopNT-out 9.952 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 7.45 APE8-rot-out 57.97 APE67-dihe-in -59.53, -34.14 -77.79, -20.27 APE12-dist-out 17.117 APE11-dist-out 17.377 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 K 317 293 10 0 0 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 7OPOC P51812 46 347 740.0 ANP:401 ATPlike Inactive DFGinter 5.815 10.993 None -75.13, -10.43 -146.35, 169.25 -135.79, 44.23 43.29, 81.79 87.07, 14.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.74, -32.6 74.07, -63.87 none-out-out SNCnoo out-out ActLoopNT-out 10.165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.13, 122.89 APE9-dihe-na 75.62, 166.95 APE8-dihe-in -113.03, 115.92 APE8-rot-out 46.3 APE67-dihe-in -62.7, -36.2 -57.15, -32.55 APE12-dist-out 16.312 APE11-dist-out 16.934 APE10-dist-out 13.494 APE9-dist-out 6.87 None None None XRAY 2.75 0.209 0.232 C 317 295 7 0 0 0 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 7OPOG P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGinter 6.68 10.963 None -75.68, -10.29 -146.32, 168.68 -137.91, 45.72 44.25, 84.07 86.95, 15.93 out-out out 19.338 Saltbr-out 19.753 HRD-in -66.3, -31.74 74.35, -64.56 out-out-out SNCooo out-out ActLoopNT-out 10.112 ActLoopCT-out nonTYR APEdihe_aanni APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.02 APE8-rot-none 999.0 APE67-dihe-in -58.75, -33.49 -86.55, -15.46 APE12-dist-out 16.986 APE11-dist-out 17.767 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 G 317 301 2 0 0 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8EQ5A P51812 49 346 740.0 QCT:401 Type1 Inactive DFGout 22.266 9.787 None -73.88, 137.17 -86.9, 13.11 -125.85, 163.49 50.35, 92.47 -96.22, 152.3 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.97, -41.58 76.84, -49.89 none-out-out SNCnoo out-out ActLoopNT-out 15.409 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -123.13, 112.05 APE9-dihe-na -120.61, 174.84 APE8-dihe-in -88.65, 114.78 APE8-rot-in 305.94 APE67-dihe-in -62.47, -20.15 -62.23, -32.4 APE12-dist-in 13.883 APE11-dist-in 11.461 APE10-dist-out 9.67 APE9-dist-out 7.056 None None None XRAY 1.8 0.185 0.225 A 305 289 9 0 0 2 [[68, 327], [422, 679]] 2.0 8eq5 Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.1e-97 331.2 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8R58A P51812 49 348 740.0 QCT:401 Type1 Inactive DFGout 22.723 9.734 None -69.6, 133.49 -81.98, 4.89 -117.98, 155.18 46.12, 100.26 -81.19, 145.71 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.36, -38.11 64.12, -42.77 none-out-out SNCnoo out-out ActLoopNT-out 15.002 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -64.62, 110.24 APE9-dihe-na -140.48, 179.06 APE8-dihe-in -91.85, 110.78 APE8-rot-in 305.36 APE67-dihe-in -59.58, -23.45 -59.81, -33.88 APE12-dist-none 999.0 APE11-dist-in 11.825 APE10-dist-out 8.908 APE9-dist-out 7.055 None None None XRAY 2.31 0.238 0.263 A 317 282 18 0 0 11 [[68, 327], [422, 679]] 2.0 8r58 Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8XFYA P51812 58 358 740.0 A1LU8:401 Type1 Inactive DFGout 13.205 7.347 None -84.69, 175.04 -98.49, -2.97 -56.06, -41.49 288.51, 111.93 -88.04, -1.58 out-out out 13.584 Saltbr-out 12.491 HRD-out -102.98, 108.87 -62.66, -66.03 out-out-out SNCooo out-out ActLoopNT-out 5.29 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -171.34, 174.53 APE9-dihe-na 132.9, 150.52 APE8-dihe-in -54.44, 119.7 APE8-rot-in 325.6 APE67-dihe-in -67.51, -35.24 -72.39, -24.23 APE12-dist-none 999.0 APE11-dist-out 15.301 APE10-dist-out 13.362 APE9-dist-out 6.397 None None None XRAY 3.2 0.233 0.303 A 320 289 12 0 0 9 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8XFYB P51812 59 358 740.0 A1LU8:401 Type1 Inactive DFGout 12.476 7.622 None -79.21, 172.69 -104.74, 14.38 -72.96, -37.65 288.72, 121.74 -83.1, -14.53 out-out out 13.02 Saltbr-out 10.251 HRD-out -85.11, 105.26 -64.66, -55.07 out-out-out SNCooo out-out ActLoopNT-out 5.181 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -141.21, 158.45 APE9-dihe-na 119.59, 160.83 APE8-dihe-in -64.8, 132.56 APE8-rot-out 38.16 APE67-dihe-in -76.3, -33.52 -81.38, -10.91 APE12-dist-none 999.0 APE11-dist-out 15.912 APE10-dist-out 12.427 APE9-dist-out 6.369 None None None XRAY 3.2 0.233 0.303 B 320 277 23 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8XFYC P51812 61 358 740.0 A1LU8:401 Type1 Inactive DFGout 13.007 7.405 None -74.08, -176.12 -117.42, 16.75 -70.92, -31.59 288.86, 115.13 -89.42, -33.94 none-none none 999.0 Saltbr-none 999.0 HRD-out -99.11, 116.77 -79.3, -60.22 none-out-out SNCnoo out-out ActLoopNT-out 5.139 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -154.86, 91.8 APE9-dihe-na -163.03, 159.53 APE8-dihe-in -69.77, 116.03 APE8-rot-in 309.84 APE67-dihe-in -63.05, -25.35 -70.36, -29.8 APE12-dist-none 999.0 APE11-dist-out 15.692 APE10-dist-out 13.257 APE9-dist-out 6.185 None None None XRAY 3.2 0.233 0.303 C 320 272 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8XFYD P51812 63 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.68 7.718 None -85.23, 171.03 -99.91, 5.18 -66.56, -47.9 288.97, 119.73 -68.87, -42.49 none-none none 999.0 Saltbr-none 999.0 HRD-out -108.97, 107.04 -79.62, 147.57 none-out-out SNCnoo out-out ActLoopNT-out 5.004 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -160.66, -177.37 APE9-dihe-na 101.82, 157.81 APE8-dihe-in -62.84, 132.59 APE8-rot-out 47.92 APE67-dihe-in -68.43, -26.54 -77.35, -22.1 APE12-dist-none 999.0 APE11-dist-out 16.005 APE10-dist-out 13.641 APE9-dist-out 7.28 None None None XRAY 3.2 0.233 0.303 D 320 260 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8XFYE P51812 64 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.814 7.732 None -79.79, 173.69 -104.44, 5.05 -67.56, -37.65 296.33, 117.93 -76.73, -31.97 none-none none 999.0 Saltbr-none 999.0 HRD-out -107.95, 111.24 -79.69, -31.85 none-out-out SNCnoo out-out ActLoopNT-out 5.217 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -171.13, 156.06 APE9-dihe-na 118.15, 155.77 APE8-dihe-in -55.33, 128.86 APE8-rot-out 36.52 APE67-dihe-in -70.55, -22.72 -79.46, -18.88 APE12-dist-none 999.0 APE11-dist-out 16.556 APE10-dist-out 12.762 APE9-dist-in 5.579 None None None XRAY 3.2 0.233 0.303 E 320 261 24 0 0 9 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8XFYF P51812 63 345 740.0 A1LU8:401 Type1 Inactive DFGout 12.743 7.471 None -95.59, -178.42 -108.18, 9.34 -70.41, -40.72 293.14, 115.72 -77.9, -28.8 none-none none 999.0 Saltbr-none 999.0 HRD-out -100.4, 115.65 -68.34, -48.2 none-out-out SNCnoo out-out ActLoopNT-out 5.156 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -160.1, 173.9 APE9-dihe-na 114.4, 160.81 APE8-dihe-in -56.13, 119.9 APE8-rot-out 41.37 APE67-dihe-in -71.03, -16.28 -73.87, -18.19 APE12-dist-none 999.0 APE11-dist-out 15.392 APE10-dist-out 13.539 APE9-dist-out 6.404 None None None XRAY 3.2 0.233 0.303 F 320 255 28 0 0 11 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8XFYG P51812 59 346 740.0 A1LU8:401 Type1 Inactive DFGout 12.937 7.226 None -78.16, 176.02 -98.19, 0.09 -62.25, -40.75 291.8, 111.06 -81.64, -19.61 in-out in 7.881 Saltbr-out 5.486 HRD-out -91.07, 110.45 -88.21, -3.19 out-out-out SNCooo out-out ActLoopNT-out 5.164 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -71.01, 158.33 APE9-dihe-na 129.65, 145.56 APE8-dihe-in -72.78, 126.88 APE8-rot-in 303.8 APE67-dihe-in -65.24, -40.51 -67.91, -29.47 APE12-dist-none 999.0 APE11-dist-out 16.145 APE10-dist-out 12.069 APE9-dist-in 4.644 None None None XRAY 3.2 0.233 0.303 G 320 276 12 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8XFYH P51812 59 348 740.0 A1LU8:401 Type1 Inactive DFGout 13.374 7.713 None -77.26, -179.45 -100.74, 0.21 -62.05, -41.28 291.33, 112.54 -80.3, -18.96 out-out out 12.403 Saltbr-out 7.869 HRD-out -114.7, 107.73 -80.32, -3.28 out-out-out SNCooo out-out ActLoopNT-out 5.561 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -169.14, 166.07 APE9-dihe-na 97.31, 158.5 APE8-dihe-in -62.25, 138.33 APE8-rot-out 53.1 APE67-dihe-in -70.31, -30.08 -88.76, -15.85 APE12-dist-none 999.0 APE11-dist-out 15.688 APE10-dist-out 12.169 APE9-dist-in 5.119 None None None XRAY 3.2 0.233 0.303 H 320 277 13 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8XFYI P51812 63 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.485 7.394 None -79.8, 178.19 -107.54, 4.76 -62.98, -39.18 294.19, 109.04 -76.4, -38.16 none-none none 999.0 Saltbr-none 999.0 HRD-out -110.77, 98.18 -69.66, 134.16 none-out-out SNCnoo out-out ActLoopNT-out 4.941 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -128.64, 168.96 APE9-dihe-na 103.76, 142.33 APE8-dihe-in -52.02, 130.9 APE8-rot-out 52.96 APE67-dihe-in -63.86, -32.68 -78.41, -20.46 APE12-dist-none 999.0 APE11-dist-out 16.546 APE10-dist-out 12.606 APE9-dist-out 6.609 None None None XRAY 3.2 0.233 0.303 I 320 260 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 8XFYJ P51812 65 347 740.0 A1LU8:401 Type1 Inactive DFGout 12.681 7.253 None -82.1, 175.26 -103.79, -3.59 -58.74, -48.51 291.22, 109.94 -83.23, -7.51 none-none none 999.0 Saltbr-none 999.0 HRD-out -111.91, 105.75 -75.45, -19.05 none-out-out SNCnoo out-out ActLoopNT-out 5.003 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -112.59, 166.79 APE9-dihe-na 114.55, 148.33 APE8-dihe-in -68.28, 140.99 APE8-rot-in 305.08 APE67-dihe-in -73.95, -40.89 -90.2, -12.76 APE12-dist-none 999.0 APE11-dist-out 16.562 APE10-dist-out 12.863 APE9-dist-in 5.003 None None None XRAY 3.2 0.233 0.303 J 320 257 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 4NUSA P51812 53 359 740.0 2NK:1001 Type1 Inactive DFGout 13.045 7.342 None -78.78, 166.95 -80.65, -18.82 -46.42, -28.2 293.03, 106.08 -107.82, 1.09 in-out in 9.447 Saltbr-out 3.913 HRD-out -114.59, 104.74 -76.23, -8.33 out-out-out SNCooo out-out ActLoopNT-out 5.209 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.74, 153.82 APE9-dihe-na 111.28, -177.73 APE8-dihe-in -92.12, 117.05 APE8-rot-in 306.83 APE67-dihe-in -54.85, -26.24 -45.49, -49.89 APE12-dist-in 13.431 APE11-dist-out 16.163 APE10-dist-out 10.59 APE9-dist-in 4.083 None None None XRAY 2.39 0.191 0.231 A 323 301 0 0 0 0 [[68, 327], [422, 679]] 2.0 4nus Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 5D9LA P51812 49 359 740.0 583:1001 Type1 Inactive DFGout 13.125 7.071 None -75.24, 167.74 -87.99, -6.69 -50.57, -47.91 290.28, 116.72 -91.68, 11.14 in-out in 8.137 Saltbr-out 7.416 HRD-out -120.21, 105.54 -83.41, 126.5 out-out-out SNCooo out-out ActLoopNT-out 5.263 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.74 APE8-dihe-in -60.19, 116.14 APE8-rot-in 302.87 APE67-dihe-in -59.28, -26.44 -61.48, -36.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.864 None None None XRAY 2.15 0.168 0.224 A 323 299 12 0 0 12 [[68, 327], [422, 679]] 2.0 5d9l Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 5D9KA P51812 62 359 740.0 584:401 Type1 Inactive DFGout 12.972 7.703 None -70.85, 175.06 -99.81, -5.69 -54.85, -40.91 296.9, 103.08 -90.51, 7.61 in-out in 9.757 Saltbr-out 5.95 HRD-out -115.19, 98.47 -57.55, -41.76 out-out-out SNCooo out-out ActLoopNT-out 4.895 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 132.75 APE9-dihe-na 132.11, 175.33 APE8-dihe-in -91.17, 111.44 APE8-rot-in 313.37 APE67-dihe-in -60.35, -22.61 -61.26, -30.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.938 APE9-dist-in 5.828 None None None XRAY 2.55 0.183 0.227 A 330 280 12 0 0 12 [[68, 327], [422, 679]] 2.0 5d9k Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.8e-97 330.8 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_HUMAN 5D9KB P51812 62 359 740.0 584:401 Type1 Inactive DFGout 12.94 7.705 None -71.4, 176.28 -100.1, -5.4 -52.09, -44.72 291.08, 99.76 -90.94, 9.31 in-none in 9.81 Saltbr-none 999.0 HRD-out -114.53, 98.39 -57.41, -41.87 none-out-out SNCnoo out-out ActLoopNT-out 5.428 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 137.48 APE9-dihe-na 131.93, 176.62 APE8-dihe-in -91.59, 110.99 APE8-rot-in 314.15 APE67-dihe-in -59.51, -22.8 -61.13, -31.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.286 APE9-dist-in 5.876 None None None XRAY 2.55 0.183 0.227 B 330 280 11 0 0 11 [[68, 327], [422, 679]] 2.0 5d9k Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.8e-97 330.8 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_MOUSE 3G51A P18654 47 346 740.0 ANP:480 ATPlike Inactive DFGin 5.92 11.041 None -85.91, -4.29 -148.29, 179.42 -140.68, 33.76 40.5, 80.74 98.88, 16.23 none-none none 999.0 Saltbr-none 999.0 HRD-in -65.38, -43.56 85.71, -58.97 none-out-none SNCnon out-none ActLoopNT-out 10.075 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.27 APE8-rot-in 334.43 APE67-dihe-in -57.95, -24.46 -80.48, -16.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.216 0.248 A 325 280 20 0 0 11 [[68, 327], [422, 679]] 2.0 3g51 Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_MOUSE 3UBDA P18654 49 346 740.0 SL0:400 Type1 Inactive DFGout 22.444 9.838 None -70.61, 138.35 -88.42, 8.69 -121.25, 153.55 52.73, 95.26 -87.34, 152.26 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.26, -47.12 78.18, -50.54 none-out-out SNCnoo out-out ActLoopNT-out 14.988 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -113.99, 96.24 APE9-dihe-na -97.91, 148.8 APE8-dihe-in -79.2, 109.54 APE8-rot-in 299.5 APE67-dihe-in -58.49, -23.13 -54.85, -39.16 APE12-dist-in 13.584 APE11-dist-in 11.075 APE10-dist-out 8.818 APE9-dist-out 6.578 None None None XRAY 1.53 0.195 0.223 A 304 287 11 0 0 5 [[68, 327], [422, 679]] 2.0 3ubd Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.1e-97 331.2 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_MOUSE 4EL9A P18654 49 346 740.0 AFE:400 Type1 Inactive DFGout 22.395 9.808 None -73.23, 140.2 -88.81, 8.12 -121.45, 151.95 53.82, 95.87 -80.4, 148.97 none-none none 999.0 Saltbr-none 999.0 HRD-in -73.14, -47.46 84.19, -56.79 none-out-out SNCnoo out-out ActLoopNT-out 15.312 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -117.53, 106.32 APE9-dihe-na -111.78, 156.34 APE8-dihe-in -73.67, 109.22 APE8-rot-in 303.69 APE67-dihe-in -56.7, -22.51 -55.9, -38.19 APE12-dist-out 14.062 APE11-dist-in 11.629 APE10-dist-out 10.074 APE9-dist-out 6.859 None None None XRAY 1.55 0.226 0.226 A 305 290 8 0 0 3 [[68, 327], [422, 679]] 2.0 4el9 Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.1e-97 331.2 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_MOUSE 4GUEA P18654 48 346 740.0 QCT:401 Type1 Inactive DFGout 22.498 9.854 None -76.85, 138.45 -89.03, 9.91 -123.65, 154.79 53.62, 94.84 -83.43, 143.84 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.45, -44.65 78.33, -54.21 none-out-out SNCnoo out-out ActLoopNT-out 15.451 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -130.21, 92.23 APE9-dihe-na -99.38, 166.62 APE8-dihe-in -88.89, 109.57 APE8-rot-in 300.88 APE67-dihe-in -54.39, -25.95 -55.17, -36.68 APE12-dist-out 14.033 APE11-dist-in 11.666 APE10-dist-out 10.001 APE9-dist-out 6.854 None None None XRAY 1.8 0.173 0.205 A 305 286 13 0 0 5 [[68, 327], [422, 679]] 2.0 4gue Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.1e-97 331.2 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3

AGC_RPS6KA3-1 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 4
Active chains: 0
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 3 75.0% 4EL9A
DFGin None 1 25.0% 3G51A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
KS6A3_MOUSE 3G51A P18654 47 346 740.0 ANP:480 ATPlike Inactive DFGin 5.92 11.041 None -85.91, -4.29 -148.29, 179.42 -140.68, 33.76 40.5, 80.74 98.88, 16.23 none-none none 999.0 Saltbr-none 999.0 HRD-in -65.38, -43.56 85.71, -58.97 none-out-none SNCnon out-none ActLoopNT-out 10.075 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.27 APE8-rot-in 334.43 APE67-dihe-in -57.95, -24.46 -80.48, -16.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.216 0.248 A 325 280 20 0 0 11 [[68, 327], [422, 679]] 2.0 3g51 Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_MOUSE 3UBDA P18654 49 346 740.0 SL0:400 Type1 Inactive DFGout 22.444 9.838 None -70.61, 138.35 -88.42, 8.69 -121.25, 153.55 52.73, 95.26 -87.34, 152.26 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.26, -47.12 78.18, -50.54 none-out-out SNCnoo out-out ActLoopNT-out 14.988 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -113.99, 96.24 APE9-dihe-na -97.91, 148.8 APE8-dihe-in -79.2, 109.54 APE8-rot-in 299.5 APE67-dihe-in -58.49, -23.13 -54.85, -39.16 APE12-dist-in 13.584 APE11-dist-in 11.075 APE10-dist-out 8.818 APE9-dist-out 6.578 None None None XRAY 1.53 0.195 0.223 A 304 287 11 0 0 5 [[68, 327], [422, 679]] 2.0 3ubd Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.1e-97 331.2 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_MOUSE 4EL9A P18654 49 346 740.0 AFE:400 Type1 Inactive DFGout 22.395 9.808 None -73.23, 140.2 -88.81, 8.12 -121.45, 151.95 53.82, 95.87 -80.4, 148.97 none-none none 999.0 Saltbr-none 999.0 HRD-in -73.14, -47.46 84.19, -56.79 none-out-out SNCnoo out-out ActLoopNT-out 15.312 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -117.53, 106.32 APE9-dihe-na -111.78, 156.34 APE8-dihe-in -73.67, 109.22 APE8-rot-in 303.69 APE67-dihe-in -56.7, -22.51 -55.9, -38.19 APE12-dist-out 14.062 APE11-dist-in 11.629 APE10-dist-out 10.074 APE9-dist-out 6.859 None None None XRAY 1.55 0.226 0.226 A 305 290 8 0 0 3 [[68, 327], [422, 679]] 2.0 4el9 Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.1e-97 331.2 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
KS6A3_MOUSE 4GUEA P18654 48 346 740.0 QCT:401 Type1 Inactive DFGout 22.498 9.854 None -76.85, 138.45 -89.03, 9.91 -123.65, 154.79 53.62, 94.84 -83.43, 143.84 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.45, -44.65 78.33, -54.21 none-out-out SNCnoo out-out ActLoopNT-out 15.451 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -130.21, 92.23 APE9-dihe-na -99.38, 166.62 APE8-dihe-in -88.89, 109.57 APE8-rot-in 300.88 APE67-dihe-in -54.39, -25.95 -55.17, -36.68 APE12-dist-out 14.033 APE11-dist-in 11.666 APE10-dist-out 10.001 APE9-dist-out 6.854 None None None XRAY 1.8 0.173 0.205 A 305 286 13 0 0 5 [[68, 327], [422, 679]] 2.0 4gue Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.1e-97 331.2 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3