CAMK_PRKAA2 (5'-AMP-activated protein kinase catalytic subunit alpha-2)

Total number of chains: 24
Active chains: 1
Uniprot: AAPK2_HUMAN
Kinase Domain Residues: 16 - 268
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 37.5% AF-P54646-K3A
DFGin None 6 25.0% 6B1UA
DFGin ABAminus 3 12.5% 5ISOA
None None 3 12.5% 9IC2A
DFGout BBAminus 2 8.3% 2YZAA
DFGin BLBminus 1 4.2% 7MYJA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PRKAA2 AF-P54646-K3A P54646 8 276 552.0 No_ligand No_ligand Active DFGin 6.5632 14.92 BLAminus -128.53, -178.68 49.41, 64.01 -71.26, 17.39 289.31, 83.01 -63.79, -23.37 in-in in 9.2708 Saltbr-in 2.7122 HRD-in -78.76, -48.2 65.77, -3.54 in-in-in SNCiii in-in ActLoopNT-in 2.9346 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.26, 172.51 APE9-dihe-na 85.26, 178.7 APE8-dihe-in -78.18, 130.02 APE8-rot-in 290.49 APE67-dihe-in -66.21, -20.42 -45.29, -46.43 APE12-dist-in 8.3496 APE11-dist-in 11.5318 APE10-dist-in 6.0259 APE9-dist-in 4.3092 None None None AF2 -1.0 1.0 1.0 A 269.0 269.0 0 27 27 0 [[16, 268]] 1.0 AF-P54646-K3 CAMK_PRKAA2_HUMAN CAMK 1.3e-90 309.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 5ISOA P54646 9 551 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.0764 13.7542 ABAminus -124.01, -69.61 -91.71, 113.8 -98.34, 8.3 284.02, 83.8 -52.09, -32.8 out-none out 10.6758 Saltbr-none 999.0 HRD-in -77.82, -48.64 73.79, -15.56 none-in-out SNCnio in-out ActLoopNT-in 3.0698 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -153.96, 161.46 APE9-dihe-na 108.89, 175.81 APE8-dihe-in -73.92, 127.97 APE8-rot-out 47.66 APE67-dihe-in -62.08, -29.52 -54.52, -36.25 APE12-dist-in 8.114 APE11-dist-in 11.3548 APE10-dist-in 6.5955 APE9-dist-in 5.0387 None None None XRAY 2.63 0.18 0.23 A 552.0 453.0 0 27 27 0 [[16, 268]] 1.0 5iso CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 5ISOC P54646 9 550 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.1851 14.12 ABAminus -118.95, -64.95 -97.93, 114.29 -100.77, 6.08 282.8, 83.31 -57.51, -20.09 out-none out 10.9206 Saltbr-none 999.0 HRD-in -73.97, -50.71 73.94, -15.38 none-in-out SNCnio in-out ActLoopNT-in 3.0258 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.17, 145.11 APE9-dihe-na 105.06, -178.93 APE8-dihe-in -75.45, 134.7 APE8-rot-out 182.56 APE67-dihe-in -57.91, -29.21 -54.57, -40.7 APE12-dist-in 9.0148 APE11-dist-in 11.2229 APE10-dist-in 5.4236 APE9-dist-in 4.3015 None None None XRAY 2.63 0.18 0.23 C 552.0 429.0 0 27 27 0 [[16, 268]] 1.0 5iso CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 6B1UC P54646 9 552 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.4516 14.1299 ABAminus -133.95, -50.46 -79.36, 100.93 -96.81, 22.67 283.51, 87.03 -67.96, -35.6 out-out out 10.2466 Saltbr-out 4.344 HRD-in -62.69, -52.12 64.78, 6.12 out-in-out SNCoio in-out ActLoopNT-in 3.0313 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 59.85, -130.04 APE9-dihe-na -84.76, -170.01 APE8-dihe-in -60.51, 139.79 APE8-rot-out 157.81 APE67-dihe-in -64.49, -24.93 -66.94, -29.94 APE12-dist-in 7.802 APE11-dist-in 10.1021 APE10-dist-in 6.0757 APE9-dist-in 4.4225 None TPO172 TPO172 XRAY 2.77 0.196 0.226 C 565.0 460.0 0 27 27 0 [[16, 268]] 1.0 6b1u CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AF-P54646-K1A P54646 8 276 552.0 No_ligand No_ligand Inactive DFGin 6.9959 14.3917 BLAminus -126.65, -178.74 48.21, 68.91 -76.73, 17.03 284.78, 80.25 -64.23, -25.86 in-in in 9.5465 Saltbr-in 2.7283 HRD-in -79.4, -50.56 62.71, 8.55 in-in-out SNCiio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.74, 170.76 APE9-dihe-na 91.37, 170.87 APE8-dihe-in -69.68, 134.71 APE8-rot-out 178.73 APE67-dihe-in -68.81, -20.53 -48.7, -44.19 APE12-dist-in 8.3506 APE11-dist-in 11.4204 APE10-dist-in 5.6475 APE9-dist-in 3.5622 None None None AF2 -1.0 1.0 1.0 A 269.0 269.0 0 27 27 0 [[16, 268]] 1.0 AF-P54646-K1 CAMK_PRKAA2_HUMAN CAMK 1.3e-90 309.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 4ZHXA P54646 9 550 552.0 4O7:60601 Type1 Inactive DFGin 7.3137 14.4909 BLAminus -135.96, 174.74 63.62, 78.79 -96.49, 25.87 279.49, 89.41 -67.04, -42.41 in-in in 9.8225 Saltbr-in 2.8127 HRD-in -62.82, -50.16 66.02, -7.55 in-in-out SNCiio in-out ActLoopNT-in 3.0918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.21, 142.03 APE9-dihe-na 100.41, 173.94 APE8-dihe-in -70.43, 143.38 APE8-rot-out 182.77 APE67-dihe-in -66.84, -29.69 -60.0, -32.86 APE12-dist-in 7.9354 APE11-dist-in 10.3911 APE10-dist-in 4.8353 APE9-dist-in 3.9049 None TPO172 TPO172 XRAY 2.99 0.226 0.243 A 565.0 409.0 0 27 27 0 [[16, 268]] 1.0 4zhx CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 4CFFA P54646 8 551 552.0 STU:61552 Type1 Inactive DFGin 7.0564 14.0818 BLAminus -149.77, 179.95 57.3, 81.92 -95.29, 37.99 289.6, 92.87 -75.43, -19.2 out-out out 10.9893 Saltbr-out 5.616 HRD-out -79.02, 102.38 -90.23, 5.49 out-in-out SNCoio in-out ActLoopNT-in 3.1062 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -140.4, 154.3 APE9-dihe-na 120.73, -179.28 APE8-dihe-in -68.72, 155.02 APE8-rot-out 179.49 APE67-dihe-out -92.39, 175.4 -57.6, -33.75 APE12-dist-in 7.9516 APE11-dist-in 11.1768 APE10-dist-in 5.5536 APE9-dist-in 3.902 None TPO172 TPO172 XRAY 3.924 0.211 0.264 A 571.0 425.0 0 27 27 0 [[16, 268]] 1.0 4cff CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 8BIKA P54646 8 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.4108 14.1375 BLAminus -139.87, 175.04 60.92, 88.41 -94.92, 18.04 278.75, 87.35 -59.01, -34.32 out-in out 10.1739 Saltbr-in 2.8766 HRD-in -67.48, -51.05 72.2, -5.59 in-in-out SNCiio in-out ActLoopNT-in 3.0285 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.52, 150.63 APE9-dihe-na 107.16, 178.8 APE8-dihe-in -62.54, 134.22 APE8-rot-out 175.32 APE67-dihe-in -59.81, -28.17 -63.52, -36.76 APE12-dist-in 7.7788 APE11-dist-in 11.4392 APE10-dist-in 5.7681 APE9-dist-in 4.246 None None None XRAY 2.5 0.183 0.215 A 559.0 451.0 0 27 27 0 [[16, 268]] 1.0 8bik CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 8BIKD P54646 9 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.384 14.4446 BLAminus -141.24, 172.63 63.28, 83.56 -89.35, 21.67 278.42, 85.15 -58.54, -35.7 out-in out 10.1752 Saltbr-in 2.8052 HRD-in -67.72, -52.05 72.56, -5.24 in-in-out SNCiio in-out ActLoopNT-in 3.0392 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.07, 151.38 APE9-dihe-na 109.6, 178.13 APE8-dihe-in -63.22, 133.31 APE8-rot-out 174.24 APE67-dihe-in -63.88, -27.23 -63.0, -33.55 APE12-dist-in 7.8083 APE11-dist-in 11.3382 APE10-dist-in 5.6939 APE9-dist-in 4.2241 None None None XRAY 2.5 0.183 0.215 D 559.0 443.0 0 27 27 0 [[16, 268]] 1.0 8bik CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 6B2EA P54646 9 551 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 6.8359 14.6749 BLAminus -127.75, -179.24 60.25, 73.12 -88.18, 14.06 273.69, 88.23 -67.6, -15.67 out-none out 10.0019 Saltbr-none 999.0 HRD-out -78.51, 91.55 -68.49, -19.81 none-in-out SNCnio in-out ActLoopNT-in 3.1235 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiio APE10-dihe-na -70.16, 148.6 APE9-dihe-na -63.35, -41.66 APE8-dihe-in -61.85, 118.31 APE8-rot-out 58.89 APE67-dihe-out -81.11, 165.06 -67.04, -35.27 APE12-dist-in 8.4672 APE11-dist-in 10.8 APE10-dist-in 6.9386 APE9-dist-out 8.497 None TPO172 TPO172 XRAY 3.8 0.246 0.277 A 565.0 443.0 0 27 27 0 [[16, 268]] 1.0 6b2e CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 4CFEA P54646 8 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 7.0796 14.0721 BLAminus -145.68, 179.18 60.7, 83.63 -96.97, 26.73 284.08, 87.71 -65.51, -24.73 out-out out 10.7276 Saltbr-out 5.3537 HRD-out -86.27, 102.77 -89.89, 0.95 out-in-out SNCoio in-out ActLoopNT-in 3.1121 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -129.79, 163.12 APE9-dihe-na 115.46, -178.56 APE8-dihe-in -67.55, 156.43 APE8-rot-out 179.35 APE67-dihe-out -75.24, 179.33 -55.61, -52.75 APE12-dist-in 7.8317 APE11-dist-in 11.1822 APE10-dist-in 5.5022 APE9-dist-in 4.035 None TPO172 TPO172 XRAY 3.023 0.219 0.253 A 571.0 426.0 0 27 27 0 [[16, 268]] 1.0 4cfe CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 4CFEC P54646 10 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 6.7879 14.041 BLAminus -149.49, 177.86 54.08, 78.43 -74.33, -60.5 283.52, 75.88 44.88, -65.29 out-out out 10.8275 Saltbr-out 5.2457 HRD-out -83.19, 107.96 -92.05, 0.22 out-in-out SNCoio in-out ActLoopNT-in 2.9738 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -138.71, 159.05 APE9-dihe-na 117.28, 177.67 APE8-dihe-in -66.82, 154.33 APE8-rot-out 184.3 APE67-dihe-out -85.99, 172.12 -55.69, -41.12 APE12-dist-in 7.7099 APE11-dist-in 11.0432 APE10-dist-in 5.4181 APE9-dist-in 4.2153 None TPO172 TPO172 XRAY 3.023 0.219 0.253 C 571.0 404.0 0 27 27 0 [[16, 268]] 1.0 4cfe CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 7MYJA P54646 7 551 552.0 4O7:601,ZQV:602 Type1,Allosteric Inactive DFGin 7.2229 14.6765 BLBminus -152.67, -169.11 58.79, 44.81 -59.77, 131.43 276.12, 78.05 155.12, 161.96 out-in out 10.1362 Saltbr-in 3.1155 HRD-in -55.27, -43.43 60.07, 11.28 in-in-in SNCiii in-in ActLoopNT-in 3.3837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.1, 141.22 APE9-dihe-na 117.39, 172.14 APE8-dihe-in -80.27, 145.43 APE8-rot-in 299.08 APE67-dihe-in -63.29, -25.25 -56.99, -36.08 APE12-dist-in 7.6517 APE11-dist-in 9.9454 APE10-dist-in 4.4597 APE9-dist-in 3.7694 None TPO172 TPO172 XRAY 2.95 0.215 0.243 A 565.0 435.0 0 27 27 0 [[16, 268]] 1.0 7myj CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 7MYJC P54646 8 551 552.0 4O7:601 Type1 Inactive DFGin 7.3145 14.0838 None -132.52, -55.68 -74.88, 101.59 -98.84, 25.6 284.87, 89.61 -69.31, -43.09 out-in out 10.1906 Saltbr-in 3.2112 HRD-in -59.12, -60.67 79.22, -0.71 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.77, 22.41 APE9-dihe-na -62.18, -179.97 APE8-dihe-in -59.88, 136.16 APE8-rot-in 296.22 APE67-dihe-in -61.7, -38.21 -62.19, -37.1 APE12-dist-in 8.6761 APE11-dist-out 7.9979 APE10-dist-out 8.1101 APE9-dist-in 4.3745 None TPO172 TPO172 XRAY 2.95 0.215 0.243 C 565.0 465.0 0 27 27 0 [[16, 268]] 1.0 7myj CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 5EZVA P54646 8 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.2674 14.6333 None -121.03, -63.06 -68.65, 101.9 -100.19, 25.35 279.34, 91.81 -68.17, -44.69 in-in in 9.8608 Saltbr-in 2.6899 HRD-in -59.46, -47.11 63.8, -4.14 in-in-in SNCiii in-in ActLoopNT-in 3.0028 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.63, 144.51 APE9-dihe-na 86.66, 177.12 APE8-dihe-in -64.88, 140.75 APE8-rot-in 312.82 APE67-dihe-in -66.61, -22.38 -58.4, -32.39 APE12-dist-in 7.7539 APE11-dist-in 10.4368 APE10-dist-in 5.1306 APE9-dist-in 4.4026 None TPO172 TPO172 XRAY 2.99 0.225 0.245 A 560.0 433.0 0 27 27 0 [[16, 268]] 1.0 5ezv CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 5EZVC P54646 9 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.4323 14.3494 None -121.9, -67.2 -69.32, 103.91 -104.03, 30.29 280.2, 90.51 -70.5, -44.85 out-in out 10.4146 Saltbr-in 3.2079 HRD-in -65.9, -50.28 64.78, -4.1 in-in-out SNCiio in-out ActLoopNT-in 2.9393 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.83, 151.12 APE9-dihe-na 88.46, 177.26 APE8-dihe-in -64.21, 140.09 APE8-rot-out 194.68 APE67-dihe-in -65.12, -32.21 -57.93, -31.87 APE12-dist-in 7.8362 APE11-dist-in 10.5358 APE10-dist-in 5.1127 APE9-dist-in 4.4856 None TPO172 TPO172 XRAY 2.99 0.225 0.245 C 560.0 434.0 0 27 27 0 [[16, 268]] 1.0 5ezv CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 4ZHXC P54646 9 551 552.0 4O7:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.1494 14.357 None -118.59, -65.8 -66.91, 99.09 -101.33, 23.32 277.19, 90.56 -65.31, -32.83 out-out out 10.3303 Saltbr-out 4.842 HRD-out -73.9, 101.83 -92.2, 22.13 out-in-out SNCoio in-out ActLoopNT-in 2.9999 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -139.02, 115.25 APE9-dihe-na 47.21, -160.8 APE8-dihe-out 29.45, 76.85 APE8-rot-in 332.18 APE67-dihe-in -70.92, -30.7 -62.41, -34.95 APE12-dist-in 7.9051 APE11-dist-in 10.9947 APE10-dist-in 5.5352 APE9-dist-out 6.3235 None TPO172 TPO172 XRAY 2.99 0.226 0.243 C 565.0 453.0 0 27 27 0 [[16, 268]] 1.0 4zhx CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 6B1UA P54646 8 550 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.2691 14.4408 None -129.47, -55.38 -79.75, 100.47 -94.16, 25.18 281.88, 87.91 -69.36, -38.1 out-in out 10.0903 Saltbr-in 2.8061 HRD-in -70.7, -48.35 62.09, 8.12 in-in-out SNCiio in-out ActLoopNT-in 3.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.71, 141.45 APE9-dihe-na 98.59, 173.56 APE8-dihe-in -72.38, 142.58 APE8-rot-out 181.03 APE67-dihe-in -62.9, -27.33 -58.67, -32.16 APE12-dist-in 7.9718 APE11-dist-in 10.5218 APE10-dist-in 4.9765 APE9-dist-in 3.8757 None TPO172 TPO172 XRAY 2.77 0.196 0.226 A 565.0 442.0 0 27 27 0 [[16, 268]] 1.0 6b1u CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 4CFFC P54646 10 551 552.0 STU:61552,C1V:61553 Type1,Allosteric Inactive DFGin 6.7813 14.0798 None -150.62, -172.52 53.67, 68.27 -65.24, -76.3 281.99, 78.69 54.48, -69.27 out-out out 10.8955 Saltbr-out 5.3095 HRD-out -84.81, 105.73 -92.0, 12.06 out-in-out SNCoio in-out ActLoopNT-in 3.0342 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -122.19, 170.3 APE9-dihe-na 112.32, 178.27 APE8-dihe-in -67.95, 156.54 APE8-rot-out 180.36 APE67-dihe-out -82.42, 177.62 -55.27, -42.84 APE12-dist-in 7.7542 APE11-dist-in 11.1374 APE10-dist-in 5.4326 APE9-dist-in 3.967 None TPO172 TPO172 XRAY 3.924 0.211 0.264 C 571.0 423.0 0 27 27 0 [[16, 268]] 1.0 4cff CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 2H6DA P54646 10 278 552.0 No_ligand No_ligand Inactive DFGout 11.8452 7.1042 BBAminus -152.16, 154.47 -117.04, 79.79 -110.32, -10.32 283.93, 166.98 70.98, 25.92 out-out out 10.7474 Saltbr-out 6.3906 HRD-out -73.29, 137.37 -127.09, 129.61 out-out-none SNCoon out-none ActLoopNT-out 21.5946 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.19 0.227 A 276.0 256.0 13 27 14 13 [[16, 268]] 1.0 2h6d CAMK_PRKAA2_HUMAN CAMK 1.4e-90 309.0 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 2YZAA P54646 10 278 552.0 No_ligand No_ligand Inactive DFGout 12.1922 7.3697 BBAminus -149.17, 154.51 -108.81, 78.71 -105.69, -18.57 293.72, 150.6 70.96, 51.49 out-out out 10.8749 Saltbr-out 6.2652 HRD-out -63.53, 126.04 -112.67, 118.39 out-out-none SNCoon out-none ActLoopNT-out 21.9394 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 139.08 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T172D None None XRAY 3.02 0.235 0.308 A 276.0 258.0 11 27 16 11 [[16, 268]] 1.0 2yza CAMK_PRKAA2_HUMAN CAMK 3.3e-90 307.8 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 9IC2A P54646 8 279 552.0 A1I1Y:301 Type1 Inactive None 12.5559 18.5525 None -79.46, 135.77 -63.99, 160.78 -84.21, 28.87 306.2, 151.76 -87.24, 157.09 out-out out 11.6512 Saltbr-out 9.9153 HRD-out -100.01, -19.83 -119.62, 164.07 out-out-out SNCooo out-out ActLoopNT-out 11.5427 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -116.89, 24.87 APE9-dihe-na 152.32, 169.97 APE8-dihe-out -132.57, -51.27 APE8-rot-in 331.53 APE67-dihe-in -61.89, -23.41 -74.28, -2.72 APE12-dist-none 999.0 APE11-dist-out 21.1063 APE10-dist-out 25.6011 APE9-dist-out 19.7621 None None None XRAY 2.5 0.199 0.235 A 276.0 267.0 5 27 22 5 [[16, 268]] 1.0 9ic2 CAMK_PRKAA2_HUMAN CAMK 1.4e-90 309.0 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 3AQVA P54646 7 279 552.0 TAK:1 Type1 Inactive None 11.4178 16.606 None -77.64, 137.51 -58.36, 143.4 -127.83, 21.4 46.24, 88.73 -78.74, -145.72 out-out out 11.2516 Saltbr-out 5.1804 HRD-out -77.57, 129.2 -132.8, 160.46 out-out-none SNCoon out-none ActLoopNT-out 11.2812 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.84, 102.31 999.0, -56.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T172D None None XRAY 2.08 0.224 0.281 A 276.0 267.0 6 27 21 6 [[16, 268]] 1.0 3aqv CAMK_PRKAA2_HUMAN CAMK 3.3e-90 307.8 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 6BX6A P54646 13 277 552.0 EDJ:301 Type1 Inactive None 13.0625 18.1763 None -83.27, 141.71 -56.85, 150.64 -90.91, 68.68 316.75, 131.0 -125.61, 179.32 out-none out 11.7807 Saltbr-none 999.0 HRD-out -139.99, 154.46 -128.08, 142.18 none-out-none SNCnon out-none ActLoopNT-out 9.4538 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T172D None None XRAY 2.9 0.253 0.28 A 276.0 243.0 22 27 11 16 [[16, 268]] 1.0 6bx6 CAMK_PRKAA2_HUMAN CAMK 3.3e-90 307.8 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2

CAMK_PRKAA2 (5'-AMP-activated protein kinase catalytic subunit alpha-2)

Total number of chains: 24
Active chains: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 37.5% AF-P54646-K3A
DFGin None 6 25.0% 6B1UA
DFGin ABAminus 3 12.5% 5ISOA
None None 3 12.5% 9IC2A
DFGout BBAminus 2 8.3% 2YZAA
DFGin BLBminus 1 4.2% 7MYJA

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PRKAA2 AAPK2_HUMAN AF-P54646-K3A P54646 8 276 552.0 No_ligand No_ligand Active DFGin 6.5632 14.92 BLAminus -128.53, -178.68 49.41, 64.01 -71.26, 17.39 289.31, 83.01 -63.79, -23.37 in-in in 9.2708 Saltbr-in 2.7122 HRD-in -78.76, -48.2 65.77, -3.54 in-in-in SNCiii in-in ActLoopNT-in 2.9346 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.26, 172.51 APE9-dihe-na 85.26, 178.7 APE8-dihe-in -78.18, 130.02 APE8-rot-in 290.49 APE67-dihe-in -66.21, -20.42 -45.29, -46.43 APE12-dist-in 8.3496 APE11-dist-in 11.5318 APE10-dist-in 6.0259 APE9-dist-in 4.3092 None None None AF2 -1.0 1.0 1.0 A 269.0 269.0 0 27 27 0 [[16, 268]] 1.0 AF-P54646-K3 Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.3e-90 309.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 5ISOA P54646 9 551 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.0764 13.7542 ABAminus -124.01, -69.61 -91.71, 113.8 -98.34, 8.3 284.02, 83.8 -52.09, -32.8 out-none out 10.6758 Saltbr-none 999.0 HRD-in -77.82, -48.64 73.79, -15.56 none-in-out SNCnio in-out ActLoopNT-in 3.0698 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -153.96, 161.46 APE9-dihe-na 108.89, 175.81 APE8-dihe-in -73.92, 127.97 APE8-rot-out 47.66 APE67-dihe-in -62.08, -29.52 -54.52, -36.25 APE12-dist-in 8.114 APE11-dist-in 11.3548 APE10-dist-in 6.5955 APE9-dist-in 5.0387 None None None XRAY 2.63 0.18 0.23 A 552.0 453.0 0 27 27 0 [[16, 268]] 1.0 5iso Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 5ISOC P54646 9 550 552.0 STU:601,992:602 Type1,Allosteric Inactive DFGin 7.1851 14.12 ABAminus -118.95, -64.95 -97.93, 114.29 -100.77, 6.08 282.8, 83.31 -57.51, -20.09 out-none out 10.9206 Saltbr-none 999.0 HRD-in -73.97, -50.71 73.94, -15.38 none-in-out SNCnio in-out ActLoopNT-in 3.0258 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.17, 145.11 APE9-dihe-na 105.06, -178.93 APE8-dihe-in -75.45, 134.7 APE8-rot-out 182.56 APE67-dihe-in -57.91, -29.21 -54.57, -40.7 APE12-dist-in 9.0148 APE11-dist-in 11.2229 APE10-dist-in 5.4236 APE9-dist-in 4.3015 None None None XRAY 2.63 0.18 0.23 C 552.0 429.0 0 27 27 0 [[16, 268]] 1.0 5iso Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.1e-89 306.3 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 6B1UC P54646 9 552 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.4516 14.1299 ABAminus -133.95, -50.46 -79.36, 100.93 -96.81, 22.67 283.51, 87.03 -67.96, -35.6 out-out out 10.2466 Saltbr-out 4.344 HRD-in -62.69, -52.12 64.78, 6.12 out-in-out SNCoio in-out ActLoopNT-in 3.0313 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 59.85, -130.04 APE9-dihe-na -84.76, -170.01 APE8-dihe-in -60.51, 139.79 APE8-rot-out 157.81 APE67-dihe-in -64.49, -24.93 -66.94, -29.94 APE12-dist-in 7.802 APE11-dist-in 10.1021 APE10-dist-in 6.0757 APE9-dist-in 4.4225 None TPO172 TPO172 XRAY 2.77 0.196 0.226 C 565.0 460.0 0 27 27 0 [[16, 268]] 1.0 6b1u Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN AF-P54646-K1A P54646 8 276 552.0 No_ligand No_ligand Inactive DFGin 6.9959 14.3917 BLAminus -126.65, -178.74 48.21, 68.91 -76.73, 17.03 284.78, 80.25 -64.23, -25.86 in-in in 9.5465 Saltbr-in 2.7283 HRD-in -79.4, -50.56 62.71, 8.55 in-in-out SNCiio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.74, 170.76 APE9-dihe-na 91.37, 170.87 APE8-dihe-in -69.68, 134.71 APE8-rot-out 178.73 APE67-dihe-in -68.81, -20.53 -48.7, -44.19 APE12-dist-in 8.3506 APE11-dist-in 11.4204 APE10-dist-in 5.6475 APE9-dist-in 3.5622 None None None AF2 -1.0 1.0 1.0 A 269.0 269.0 0 27 27 0 [[16, 268]] 1.0 AF-P54646-K1 Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.3e-90 309.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 4ZHXA P54646 9 550 552.0 4O7:60601 Type1 Inactive DFGin 7.3137 14.4909 BLAminus -135.96, 174.74 63.62, 78.79 -96.49, 25.87 279.49, 89.41 -67.04, -42.41 in-in in 9.8225 Saltbr-in 2.8127 HRD-in -62.82, -50.16 66.02, -7.55 in-in-out SNCiio in-out ActLoopNT-in 3.0918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.21, 142.03 APE9-dihe-na 100.41, 173.94 APE8-dihe-in -70.43, 143.38 APE8-rot-out 182.77 APE67-dihe-in -66.84, -29.69 -60.0, -32.86 APE12-dist-in 7.9354 APE11-dist-in 10.3911 APE10-dist-in 4.8353 APE9-dist-in 3.9049 None TPO172 TPO172 XRAY 2.99 0.226 0.243 A 565.0 409.0 0 27 27 0 [[16, 268]] 1.0 4zhx Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 4CFFA P54646 8 551 552.0 STU:61552 Type1 Inactive DFGin 7.0564 14.0818 BLAminus -149.77, 179.95 57.3, 81.92 -95.29, 37.99 289.6, 92.87 -75.43, -19.2 out-out out 10.9893 Saltbr-out 5.616 HRD-out -79.02, 102.38 -90.23, 5.49 out-in-out SNCoio in-out ActLoopNT-in 3.1062 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -140.4, 154.3 APE9-dihe-na 120.73, -179.28 APE8-dihe-in -68.72, 155.02 APE8-rot-out 179.49 APE67-dihe-out -92.39, 175.4 -57.6, -33.75 APE12-dist-in 7.9516 APE11-dist-in 11.1768 APE10-dist-in 5.5536 APE9-dist-in 3.902 None TPO172 TPO172 XRAY 3.924 0.211 0.264 A 571.0 425.0 0 27 27 0 [[16, 268]] 1.0 4cff Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 8BIKA P54646 8 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.4108 14.1375 BLAminus -139.87, 175.04 60.92, 88.41 -94.92, 18.04 278.75, 87.35 -59.01, -34.32 out-in out 10.1739 Saltbr-in 2.8766 HRD-in -67.48, -51.05 72.2, -5.59 in-in-out SNCiio in-out ActLoopNT-in 3.0285 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.52, 150.63 APE9-dihe-na 107.16, 178.8 APE8-dihe-in -62.54, 134.22 APE8-rot-out 175.32 APE67-dihe-in -59.81, -28.17 -63.52, -36.76 APE12-dist-in 7.7788 APE11-dist-in 11.4392 APE10-dist-in 5.7681 APE9-dist-in 4.246 None None None XRAY 2.5 0.183 0.215 A 559.0 451.0 0 27 27 0 [[16, 268]] 1.0 8bik Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 8BIKD P54646 9 551 552.0 STU:61001,QTN:61002 Type1,Allosteric Inactive DFGin 7.384 14.4446 BLAminus -141.24, 172.63 63.28, 83.56 -89.35, 21.67 278.42, 85.15 -58.54, -35.7 out-in out 10.1752 Saltbr-in 2.8052 HRD-in -67.72, -52.05 72.56, -5.24 in-in-out SNCiio in-out ActLoopNT-in 3.0392 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.07, 151.38 APE9-dihe-na 109.6, 178.13 APE8-dihe-in -63.22, 133.31 APE8-rot-out 174.24 APE67-dihe-in -63.88, -27.23 -63.0, -33.55 APE12-dist-in 7.8083 APE11-dist-in 11.3382 APE10-dist-in 5.6939 APE9-dist-in 4.2241 None None None XRAY 2.5 0.183 0.215 D 559.0 443.0 0 27 27 0 [[16, 268]] 1.0 8bik Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 6B2EA P54646 9 551 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 6.8359 14.6749 BLAminus -127.75, -179.24 60.25, 73.12 -88.18, 14.06 273.69, 88.23 -67.6, -15.67 out-none out 10.0019 Saltbr-none 999.0 HRD-out -78.51, 91.55 -68.49, -19.81 none-in-out SNCnio in-out ActLoopNT-in 3.1235 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiio APE10-dihe-na -70.16, 148.6 APE9-dihe-na -63.35, -41.66 APE8-dihe-in -61.85, 118.31 APE8-rot-out 58.89 APE67-dihe-out -81.11, 165.06 -67.04, -35.27 APE12-dist-in 8.4672 APE11-dist-in 10.8 APE10-dist-in 6.9386 APE9-dist-out 8.497 None TPO172 TPO172 XRAY 3.8 0.246 0.277 A 565.0 443.0 0 27 27 0 [[16, 268]] 1.0 6b2e Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 4CFEA P54646 8 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 7.0796 14.0721 BLAminus -145.68, 179.18 60.7, 83.63 -96.97, 26.73 284.08, 87.71 -65.51, -24.73 out-out out 10.7276 Saltbr-out 5.3537 HRD-out -86.27, 102.77 -89.89, 0.95 out-in-out SNCoio in-out ActLoopNT-in 3.1121 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -129.79, 163.12 APE9-dihe-na 115.46, -178.56 APE8-dihe-in -67.55, 156.43 APE8-rot-out 179.35 APE67-dihe-out -75.24, 179.33 -55.61, -52.75 APE12-dist-in 7.8317 APE11-dist-in 11.1822 APE10-dist-in 5.5022 APE9-dist-in 4.035 None TPO172 TPO172 XRAY 3.023 0.219 0.253 A 571.0 426.0 0 27 27 0 [[16, 268]] 1.0 4cfe Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 4CFEC P54646 10 551 552.0 STU:61552,992:61553 Type1,Allosteric Inactive DFGin 6.7879 14.041 BLAminus -149.49, 177.86 54.08, 78.43 -74.33, -60.5 283.52, 75.88 44.88, -65.29 out-out out 10.8275 Saltbr-out 5.2457 HRD-out -83.19, 107.96 -92.05, 0.22 out-in-out SNCoio in-out ActLoopNT-in 2.9738 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -138.71, 159.05 APE9-dihe-na 117.28, 177.67 APE8-dihe-in -66.82, 154.33 APE8-rot-out 184.3 APE67-dihe-out -85.99, 172.12 -55.69, -41.12 APE12-dist-in 7.7099 APE11-dist-in 11.0432 APE10-dist-in 5.4181 APE9-dist-in 4.2153 None TPO172 TPO172 XRAY 3.023 0.219 0.253 C 571.0 404.0 0 27 27 0 [[16, 268]] 1.0 4cfe Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 7MYJA P54646 7 551 552.0 4O7:601,ZQV:602 Type1,Allosteric Inactive DFGin 7.2229 14.6765 BLBminus -152.67, -169.11 58.79, 44.81 -59.77, 131.43 276.12, 78.05 155.12, 161.96 out-in out 10.1362 Saltbr-in 3.1155 HRD-in -55.27, -43.43 60.07, 11.28 in-in-in SNCiii in-in ActLoopNT-in 3.3837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.1, 141.22 APE9-dihe-na 117.39, 172.14 APE8-dihe-in -80.27, 145.43 APE8-rot-in 299.08 APE67-dihe-in -63.29, -25.25 -56.99, -36.08 APE12-dist-in 7.6517 APE11-dist-in 9.9454 APE10-dist-in 4.4597 APE9-dist-in 3.7694 None TPO172 TPO172 XRAY 2.95 0.215 0.243 A 565.0 435.0 0 27 27 0 [[16, 268]] 1.0 7myj Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 7MYJC P54646 8 551 552.0 4O7:601 Type1 Inactive DFGin 7.3145 14.0838 None -132.52, -55.68 -74.88, 101.59 -98.84, 25.6 284.87, 89.61 -69.31, -43.09 out-in out 10.1906 Saltbr-in 3.2112 HRD-in -59.12, -60.67 79.22, -0.71 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -118.77, 22.41 APE9-dihe-na -62.18, -179.97 APE8-dihe-in -59.88, 136.16 APE8-rot-in 296.22 APE67-dihe-in -61.7, -38.21 -62.19, -37.1 APE12-dist-in 8.6761 APE11-dist-out 7.9979 APE10-dist-out 8.1101 APE9-dist-in 4.3745 None TPO172 TPO172 XRAY 2.95 0.215 0.243 C 565.0 465.0 0 27 27 0 [[16, 268]] 1.0 7myj Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 5EZVA P54646 8 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.2674 14.6333 None -121.03, -63.06 -68.65, 101.9 -100.19, 25.35 279.34, 91.81 -68.17, -44.69 in-in in 9.8608 Saltbr-in 2.6899 HRD-in -59.46, -47.11 63.8, -4.14 in-in-in SNCiii in-in ActLoopNT-in 3.0028 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.63, 144.51 APE9-dihe-na 86.66, 177.12 APE8-dihe-in -64.88, 140.75 APE8-rot-in 312.82 APE67-dihe-in -66.61, -22.38 -58.4, -32.39 APE12-dist-in 7.7539 APE11-dist-in 10.4368 APE10-dist-in 5.1306 APE9-dist-in 4.4026 None TPO172 TPO172 XRAY 2.99 0.225 0.245 A 560.0 433.0 0 27 27 0 [[16, 268]] 1.0 5ezv Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 5EZVC P54646 9 551 552.0 STU:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.4323 14.3494 None -121.9, -67.2 -69.32, 103.91 -104.03, 30.29 280.2, 90.51 -70.5, -44.85 out-in out 10.4146 Saltbr-in 3.2079 HRD-in -65.9, -50.28 64.78, -4.1 in-in-out SNCiio in-out ActLoopNT-in 2.9393 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.83, 151.12 APE9-dihe-na 88.46, 177.26 APE8-dihe-in -64.21, 140.09 APE8-rot-out 194.68 APE67-dihe-in -65.12, -32.21 -57.93, -31.87 APE12-dist-in 7.8362 APE11-dist-in 10.5358 APE10-dist-in 5.1127 APE9-dist-in 4.4856 None TPO172 TPO172 XRAY 2.99 0.225 0.245 C 560.0 434.0 0 27 27 0 [[16, 268]] 1.0 5ezv Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 4ZHXC P54646 9 551 552.0 4O7:60601,C1V:60602 Type1,Allosteric Inactive DFGin 7.1494 14.357 None -118.59, -65.8 -66.91, 99.09 -101.33, 23.32 277.19, 90.56 -65.31, -32.83 out-out out 10.3303 Saltbr-out 4.842 HRD-out -73.9, 101.83 -92.2, 22.13 out-in-out SNCoio in-out ActLoopNT-in 2.9999 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -139.02, 115.25 APE9-dihe-na 47.21, -160.8 APE8-dihe-out 29.45, 76.85 APE8-rot-in 332.18 APE67-dihe-in -70.92, -30.7 -62.41, -34.95 APE12-dist-in 7.9051 APE11-dist-in 10.9947 APE10-dist-in 5.5352 APE9-dist-out 6.3235 None TPO172 TPO172 XRAY 2.99 0.226 0.243 C 565.0 453.0 0 27 27 0 [[16, 268]] 1.0 4zhx Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 6B1UA P54646 8 550 552.0 STU:60601,CG7:60602 Type1,Allosteric Inactive DFGin 7.2691 14.4408 None -129.47, -55.38 -79.75, 100.47 -94.16, 25.18 281.88, 87.91 -69.36, -38.1 out-in out 10.0903 Saltbr-in 2.8061 HRD-in -70.7, -48.35 62.09, 8.12 in-in-out SNCiio in-out ActLoopNT-in 3.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.71, 141.45 APE9-dihe-na 98.59, 173.56 APE8-dihe-in -72.38, 142.58 APE8-rot-out 181.03 APE67-dihe-in -62.9, -27.33 -58.67, -32.16 APE12-dist-in 7.9718 APE11-dist-in 10.5218 APE10-dist-in 4.9765 APE9-dist-in 3.8757 None TPO172 TPO172 XRAY 2.77 0.196 0.226 A 565.0 442.0 0 27 27 0 [[16, 268]] 1.0 6b1u Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.2 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 4CFFC P54646 10 551 552.0 STU:61552,C1V:61553 Type1,Allosteric Inactive DFGin 6.7813 14.0798 None -150.62, -172.52 53.67, 68.27 -65.24, -76.3 281.99, 78.69 54.48, -69.27 out-out out 10.8955 Saltbr-out 5.3095 HRD-out -84.81, 105.73 -92.0, 12.06 out-in-out SNCoio in-out ActLoopNT-in 3.0342 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -122.19, 170.3 APE9-dihe-na 112.32, 178.27 APE8-dihe-in -67.95, 156.54 APE8-rot-out 180.36 APE67-dihe-out -82.42, 177.62 -55.27, -42.84 APE12-dist-in 7.7542 APE11-dist-in 11.1374 APE10-dist-in 5.4326 APE9-dist-in 3.967 None TPO172 TPO172 XRAY 3.924 0.211 0.264 C 571.0 423.0 0 27 27 0 [[16, 268]] 1.0 4cff Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.2e-89 306.1 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 2H6DA P54646 10 278 552.0 No_ligand No_ligand Inactive DFGout 11.8452 7.1042 BBAminus -152.16, 154.47 -117.04, 79.79 -110.32, -10.32 283.93, 166.98 70.98, 25.92 out-out out 10.7474 Saltbr-out 6.3906 HRD-out -73.29, 137.37 -127.09, 129.61 out-out-none SNCoon out-none ActLoopNT-out 21.5946 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.19 0.227 A 276.0 256.0 13 27 14 13 [[16, 268]] 1.0 2h6d Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.4e-90 309.0 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 2YZAA P54646 10 278 552.0 No_ligand No_ligand Inactive DFGout 12.1922 7.3697 BBAminus -149.17, 154.51 -108.81, 78.71 -105.69, -18.57 293.72, 150.6 70.96, 51.49 out-out out 10.8749 Saltbr-out 6.2652 HRD-out -63.53, 126.04 -112.67, 118.39 out-out-none SNCoon out-none ActLoopNT-out 21.9394 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 139.08 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T172D None None XRAY 3.02 0.235 0.308 A 276.0 258.0 11 27 16 11 [[16, 268]] 1.0 2yza Homo sapiens CAMK_PRKAA2_HUMAN CAMK 3.3e-90 307.8 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 9IC2A P54646 8 279 552.0 A1I1Y:301 Type1 Inactive None 12.5559 18.5525 None -79.46, 135.77 -63.99, 160.78 -84.21, 28.87 306.2, 151.76 -87.24, 157.09 out-out out 11.6512 Saltbr-out 9.9153 HRD-out -100.01, -19.83 -119.62, 164.07 out-out-out SNCooo out-out ActLoopNT-out 11.5427 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -116.89, 24.87 APE9-dihe-na 152.32, 169.97 APE8-dihe-out -132.57, -51.27 APE8-rot-in 331.53 APE67-dihe-in -61.89, -23.41 -74.28, -2.72 APE12-dist-none 999.0 APE11-dist-out 21.1063 APE10-dist-out 25.6011 APE9-dist-out 19.7621 None None None XRAY 2.5 0.199 0.235 A 276.0 267.0 5 27 22 5 [[16, 268]] 1.0 9ic2 Homo sapiens CAMK_PRKAA2_HUMAN CAMK 1.4e-90 309.0 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 3AQVA P54646 7 279 552.0 TAK:1 Type1 Inactive None 11.4178 16.606 None -77.64, 137.51 -58.36, 143.4 -127.83, 21.4 46.24, 88.73 -78.74, -145.72 out-out out 11.2516 Saltbr-out 5.1804 HRD-out -77.57, 129.2 -132.8, 160.46 out-out-none SNCoon out-none ActLoopNT-out 11.2812 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.84, 102.31 999.0, -56.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T172D None None XRAY 2.08 0.224 0.281 A 276.0 267.0 6 27 21 6 [[16, 268]] 1.0 3aqv Homo sapiens CAMK_PRKAA2_HUMAN CAMK 3.3e-90 307.8 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
PRKAA2 AAPK2_HUMAN 6BX6A P54646 13 277 552.0 EDJ:301 Type1 Inactive None 13.0625 18.1763 None -83.27, 141.71 -56.85, 150.64 -90.91, 68.68 316.75, 131.0 -125.61, 179.32 out-none out 11.7807 Saltbr-none 999.0 HRD-out -139.99, 154.46 -128.08, 142.18 none-out-none SNCnon out-none ActLoopNT-out 9.4538 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T172D None None XRAY 2.9 0.253 0.28 A 276.0 243.0 22 27 11 16 [[16, 268]] 1.0 6bx6 Homo sapiens CAMK_PRKAA2_HUMAN CAMK 3.3e-90 307.8 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2

CAMK_PRKAA2 (5'-AMP-activated protein kinase catalytic subunit alpha-2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name