STE_MAP3K5 (Mitogen-activated protein kinase kinase kinase 5)

Total number of chains: 60
Active chains: 7
Uniprot: M3K5_HUMAN
Kinase Domain Residues: 673 - 938
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 55 91.7% AF-Q99683-K1A
DFGin None 2 3.3% 5VILC
DFGinter BABtrans 2 3.3% 2CLQA
DFGout None 1 1.7% 8QGYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q99683-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 665 - 946 0 None None Mitogen-activated protein kinase kinase kinase 5
AF-Q99683-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 665 - 946 0 None None Mitogen-activated protein kinase kinase kinase 5
6E2MA 2.253 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KK7 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
6E2NA 2.098 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KK8 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
6E2OA 2.389 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii S0L Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
6OYWA 2.603 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
6OYWD 2.603 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BICB 2.62 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nnoi No_ligand No_ligand 670 - 941 0 None T838E Mitogen-activated protein kinase kinase kinase 5
8QGYB 3.71 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 95 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
6OYTB 2.824 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnno NJV Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
5UOXA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GY Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
5UOXB 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GY Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
5UP3A 2.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GS Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
5V19A 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V4 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
5V19B 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
5V24A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 8V7 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
5V24B 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V7 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
3VW6A 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi IM6 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
3VW6B 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi IM6 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
5UORA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 8GV Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
5UORB 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GV Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
5VILA 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
5VILB 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
5VILD 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
5VIOA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
5VIOB 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
5VIOD 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
6XIHA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi V3S Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
6XIHB 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnni V3S Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
6E2MB 2.253 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi KK7 Type1 671 - 940 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
6E2OB 2.389 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi S0L Type1 671 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
6VREA 2.29 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi RFG Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
6VREB 2.29 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi RFG Type1 669 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
6OYWB 2.603 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi NKJ Type1 671 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
6OYWC 2.603 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BIBA 2.43 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi IEO Type1 670 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BIBB 2.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi IEO Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BICA 2.62 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi IE4 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BIDA 2.8 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IE8 Type1 670 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BIDB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi IE8 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BIEA 2.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi IE6 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BIEB 2.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi IE6 Type1 670 - 941 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BF2A 2.11 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BF2B 2.11 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_nnoi STU Type1 671 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BHNA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BH9 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5
4BHNB 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi BH9 Type1 670 - 938 0 None T838E Mitogen-activated protein kinase kinase kinase 5
7MU6A 2.165 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi A1AWT Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
7MU7A 2.298 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi RFG Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
7MU7B 2.298 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi RFG Type1 669 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
5VIOC 2.84 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
5VILC 2.64 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
2CLQA 2.3 Inactive DFGinter‑BABtrans out-out in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
2CLQB 2.3 Inactive DFGinter‑BABtrans in-none in-out nonTYR APEdihe_aaiii APEdist_nooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
8QGYA 3.71 Inactive DFGout‑None in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 95 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
6OYTA 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn NJV Type1 667 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
6OYTC 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn NJV Type1 671 - 938 0 None None Mitogen-activated protein kinase kinase kinase 5
6OYTD 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni NJV Type1 667 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
5UP3B 2.95 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 8GS Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5
6E2NB 2.098 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii KK8 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5
7MU6B 2.165 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii A1AWT Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5

STE_MAP3K5 (Mitogen-activated protein kinase kinase kinase 5)

Total number of chains: 60
Active chains: 7
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 55 91.7% AF-Q99683-K1A
DFGin None 2 3.3% 5VILC
DFGinter BABtrans 2 3.3% 2CLQA
DFGout None 1 1.7% 8QGYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
M3K5_HUMAN AF-Q99683-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 665 - 946 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN AF-Q99683-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 665 - 946 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6E2MA 2.253 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KK7 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6E2NA 2.098 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KK8 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6E2OA 2.389 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii S0L Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6OYWA 2.603 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6OYWD 2.603 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BICB 2.62 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nnoi No_ligand No_ligand 670 - 941 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 8QGYB 3.71 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 95 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6OYTB 2.824 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnno NJV Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5UOXA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GY Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5UOXB 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GY Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5UP3A 2.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GS Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5V19A 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V4 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5V19B 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5V24A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 8V7 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5V24B 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8V7 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 3VW6A 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi IM6 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 3VW6B 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi IM6 Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5UORA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 8GV Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5UORB 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8GV Type1 670 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5VILA 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5VILB 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5VILD 2.64 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5VIOA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5VIOB 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5VIOD 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E4 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6XIHA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi V3S Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6XIHB 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnni V3S Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6E2MB 2.253 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi KK7 Type1 671 - 940 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6E2OB 2.389 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi S0L Type1 671 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6VREA 2.29 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi RFG Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6VREB 2.29 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoi RFG Type1 669 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6OYWB 2.603 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi NKJ Type1 671 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6OYWC 2.603 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi NKJ Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BIBA 2.43 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi IEO Type1 670 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BIBB 2.43 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_nooi IEO Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BICA 2.62 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_iooi IE4 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BIDA 2.8 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IE8 Type1 670 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BIDB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi IE8 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BIEA 2.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi IE6 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BIEB 2.36 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi IE6 Type1 670 - 941 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BF2A 2.11 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 671 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BF2B 2.11 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_nnoi STU Type1 671 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BHNA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BH9 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 4BHNB 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi BH9 Type1 670 - 938 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 7MU6A 2.165 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi A1AWT Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 7MU7A 2.298 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi RFG Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 7MU7B 2.298 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi RFG Type1 669 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5VIOC 2.84 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi No_ligand No_ligand 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5VILC 2.64 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9E1 Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 2CLQA 2.3 Inactive DFGinter‑BABtrans out-out in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 2CLQB 2.3 Inactive DFGinter‑BABtrans in-none in-out nonTYR APEdihe_aaiii APEdist_nooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 8QGYA 3.71 Inactive DFGout‑None in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 95 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6OYTA 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn NJV Type1 667 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6OYTC 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn NJV Type1 671 - 938 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6OYTD 2.824 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni NJV Type1 667 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 5UP3B 2.95 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 8GS Type1 671 - 939 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 6E2NB 2.098 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii KK8 Type1 670 - 939 0 TPO838 None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
M3K5_HUMAN 7MU6B 2.165 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii A1AWT Type1 671 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens

STE_MAP3K5 (Mitogen-activated protein kinase kinase kinase 5)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism