STE_MAP3K5 (Mitogen-activated protein kinase kinase kinase 5)

Total number of chains: 60
Active chains: 7
Family: STE
Uniprot: M3K5_HUMAN
Kinase Domain Residues: 673 - 938
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 55 91.7% AF-Q99683-K1A
DFGin None 2 3.3% 5VILC
DFGinter BABtrans 2 3.3% 2CLQA
DFGout None 1 1.7% 8QGYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q99683-K1A 665 946 1374.0 No_ligand No_ligand Active DFGin 6.326 13.78 BLAminus -133.75, 172.68 64.9, 76.7 -86.04, 10.57 296.36, 98.71 -64.02, -18.97 in-in in 9.337 Saltbr-in 2.701 HRD-in -77.78, -42.95 69.92, 5.17 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.49, 155.63 APE9-dihe-na 100.41, 168.83 APE8-dihe-in -83.55, 120.96 APE8-rot-in 306.67 APE67-dihe-in -65.67, -19.75 -47.15, -43.3 APE12-dist-in 10.265 APE11-dist-in 11.013 APE10-dist-in 5.108 APE9-dist-in 3.36 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[678, 938]] 1.0 AF-Q99683-K1 STE_MAP3K5_HUMAN STE 5.1e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
AF-Q99683-K3A 665 946 1374.0 No_ligand No_ligand Active DFGin 6.042 13.888 BLAminus -134.38, 174.72 61.46, 77.42 -84.02, 5.96 293.99, 96.53 -62.32, -19.99 in-in in 9.38 Saltbr-in 2.783 HRD-in -79.49, -42.35 71.31, 5.3 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.18, 137.36 APE9-dihe-na 132.62, 179.42 APE8-dihe-in -85.9, 125.24 APE8-rot-in 302.53 APE67-dihe-in -73.41, -15.55 -49.86, -42.6 APE12-dist-in 8.839 APE11-dist-in 11.43 APE10-dist-in 5.685 APE9-dist-in 3.16 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[678, 938]] 1.0 AF-Q99683-K3 STE_MAP3K5_HUMAN STE 5.1e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6E2MA 670 939 1374.0 KK7:1001 Type1 Active DFGin 6.484 13.92 BLAminus -132.61, -176.88 59.34, 83.43 -95.61, 21.06 294.64, 87.4 -75.58, -24.51 in-in in 8.322 Saltbr-in 2.707 HRD-in -79.6, -54.85 80.2, -0.99 in-in-in SNCiii in-in ActLoopNT-in 3.018 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.09, 141.28 APE9-dihe-na 137.66, -163.35 APE8-dihe-in -108.24, 127.53 APE8-rot-in 312.25 APE67-dihe-in -79.27, 2.13 -47.64, -50.68 APE12-dist-in 8.661 APE11-dist-in 11.519 APE10-dist-in 5.809 APE9-dist-in 3.647 None TPO838 TPO838 XRAY 2.253 0.218 0.259 A 295 261 9 0 0 3 [[678, 938]] 1.0 6e2m STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6E2NA 670 939 1374.0 KK8:1001 Type1 Active DFGin 6.585 13.706 BLAminus -128.11, 176.27 63.7, 87.31 -95.72, 18.06 293.79, 96.85 -65.65, -28.4 in-in in 8.496 Saltbr-in 2.424 HRD-in -72.32, -48.31 74.73, -0.84 in-in-in SNCiii in-in ActLoopNT-in 2.841 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.92, 119.98 APE9-dihe-na 157.47, -169.23 APE8-dihe-in -101.35, 128.58 APE8-rot-in 305.37 APE67-dihe-in -74.54, -0.8 -47.59, -53.19 APE12-dist-in 8.975 APE11-dist-in 11.414 APE10-dist-in 5.699 APE9-dist-in 3.768 None TPO838 TPO838 XRAY 2.098 0.217 0.257 A 295 264 6 0 0 3 [[678, 938]] 1.0 6e2n STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6E2OA 670 939 1374.0 S0L:1001 Type1 Active DFGin 6.427 13.752 BLAminus -130.19, 177.71 63.47, 88.15 -96.82, 15.0 292.86, 87.16 -66.71, -13.24 in-in in 8.417 Saltbr-in 2.331 HRD-in -77.39, -52.31 81.18, -9.05 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.07, 124.52 APE9-dihe-na 152.3, -162.8 APE8-dihe-in -101.88, 129.38 APE8-rot-in 311.55 APE67-dihe-in -83.05, -5.3 -45.17, -51.3 APE12-dist-in 8.972 APE11-dist-in 11.336 APE10-dist-in 5.636 APE9-dist-in 3.631 None TPO838 TPO838 XRAY 2.389 0.217 0.268 A 295 264 6 0 0 4 [[678, 938]] 1.0 6e2o STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6OYWA 671 939 1374.0 NKJ:1001 Type1 Active DFGin 6.434 14.086 BLAminus -125.84, 170.11 63.72, 92.65 -105.14, 20.43 292.62, 91.43 -65.77, -22.03 in-in in 8.822 Saltbr-in 2.742 HRD-in -80.43, -46.73 68.52, 12.61 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.72, -53.83 APE9-dihe-na -69.9, -156.1 APE8-dihe-in -92.5, 138.42 APE8-rot-in 305.47 APE67-dihe-in -70.77, -12.46 -57.12, -50.56 APE12-dist-in 9.337 APE11-dist-in 11.495 APE10-dist-in 5.773 APE9-dist-in 3.364 T838E None None XRAY 2.603 0.21 0.255 A 294 261 8 0 0 5 [[678, 938]] 1.0 6oyw STE_MAP3K5_HUMAN STE 1.2e-80 276.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6OYWD 671 939 1374.0 NKJ:1001 Type1 Active DFGin 6.73 14.1 BLAminus -126.38, 171.59 64.38, 91.17 -105.76, 19.88 291.74, 93.18 -66.55, -21.17 in-in in 8.57 Saltbr-in 2.615 HRD-in -79.44, -46.61 68.22, 12.5 in-in-in SNCiii in-in ActLoopNT-in 3.081 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.59, -53.64 APE9-dihe-na -69.48, -155.47 APE8-dihe-in -94.08, 138.29 APE8-rot-in 307.43 APE67-dihe-in -70.62, -12.36 -58.47, -50.51 APE12-dist-in 9.617 APE11-dist-in 11.18 APE10-dist-in 5.582 APE9-dist-in 3.249 T838E None None XRAY 2.603 0.21 0.255 D 294 260 9 0 0 7 [[678, 938]] 1.0 6oyw STE_MAP3K5_HUMAN STE 1.2e-80 276.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BICB 670 941 1374.0 No_ligand No_ligand Inactive DFGin 6.892 13.912 BLAminus -103.89, -176.24 54.3, 109.06 -118.88, 13.34 294.77, 106.96 -69.0, -30.39 out-out out 10.251 Saltbr-out 7.438 HRD-in -71.14, -46.62 71.03, 1.85 out-in-out SNCoio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 134.01 APE9-dihe-na -123.04, -156.14 APE8-dihe-in -74.52, 124.55 APE8-rot-in 316.61 APE67-dihe-in -59.56, -26.48 -42.14, -59.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.018 APE9-dist-in 3.738 T838E None None XRAY 2.62 0.209 0.265 B 318 259 13 0 0 9 [[678, 938]] 1.0 4bic STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
8QGYB 95 940 1374.0 No_ligand No_ligand Inactive DFGin 6.296 14.627 BLAminus -118.91, -173.64 60.96, 62.83 -83.04, 12.9 285.27, 91.57 -62.95, -24.83 in-in in 8.379 Saltbr-in 2.291 HRD-in -74.5, -37.2 74.29, -11.41 in-in-out SNCiio in-out ActLoopNT-in 3.027 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.11, 161.15 APE9-dihe-na -126.52, -147.08 APE8-dihe-in -82.32, 141.14 APE8-rot-in 307.49 APE67-dihe-in -70.79, -18.31 -66.98, -41.04 APE12-dist-in 12.334 APE11-dist-out 7.514 APE10-dist-out 9.324 APE9-dist-in 3.926 None None None EM 3.71 999.0 999.0 B 896 809 0 0 0 0 [[678, 938]] 1.0 8qgy STE_MAP3K5_HUMAN STE 1.1e-79 273.9 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6OYTB 670 939 1374.0 NJV:61001 Type1 Inactive DFGin 6.064 13.619 BLAminus -123.67, 174.71 58.76, 86.33 -94.62, 25.23 301.23, 87.02 -61.68, -31.79 in-in in 8.433 Saltbr-in 3.107 HRD-in -71.92, -47.68 75.96, 1.56 in-in-out SNCiio in-out ActLoopNT-in 3.076 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -174.48 APE8-dihe-out -87.75, -23.66 APE8-rot-out 185.17 APE67-dihe-in -68.87, -21.84 -52.56, -42.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.264 None None None XRAY 2.824 0.235 0.29 B 280 238 32 0 0 10 [[678, 938]] 1.0 6oyt STE_MAP3K5_HUMAN STE 5e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5UOXA 670 940 1374.0 8GY:1000 Type1 Inactive DFGin 6.798 13.988 BLAminus -128.31, 175.13 55.09, 92.72 -100.89, 23.01 297.63, 88.22 -70.07, -26.13 in-in in 8.501 Saltbr-in 2.756 HRD-in -71.84, -50.9 74.59, 7.46 in-in-out SNCiio in-out ActLoopNT-in 3.214 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.88, 138.86 APE9-dihe-na -76.06, -175.52 APE8-dihe-in -63.3, 129.59 APE8-rot-in 321.22 APE67-dihe-in -67.41, -0.83 -64.06, -49.27 APE12-dist-in 10.796 APE11-dist-out 5.516 APE10-dist-out 10.05 APE9-dist-in 3.952 None None None XRAY 2.5 0.229 0.253 A 271 263 8 0 0 8 [[678, 938]] 1.0 5uox STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5UOXB 670 939 1374.0 8GY:1000 Type1 Inactive DFGin 6.524 13.816 BLAminus -134.06, 158.99 57.73, 94.5 -98.62, 19.22 300.63, 97.73 -64.04, -32.22 in-in in 8.572 Saltbr-in 2.661 HRD-in -75.21, -51.08 80.04, -0.5 in-in-out SNCiio in-out ActLoopNT-in 3.019 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.94, 128.06 APE9-dihe-na -81.2, -167.19 APE8-dihe-in -52.73, 117.36 APE8-rot-in 317.57 APE67-dihe-in -83.41, -9.75 -51.91, -36.4 APE12-dist-in 11.747 APE11-dist-out 7.298 APE10-dist-out 10.88 APE9-dist-in 4.486 None None None XRAY 2.5 0.229 0.253 B 271 252 18 0 0 8 [[678, 938]] 1.0 5uox STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5UP3A 670 940 1374.0 8GS:1000 Type1 Inactive DFGin 6.503 13.746 BLAminus -134.17, 163.34 57.48, 95.37 -105.83, 15.56 294.57, 82.67 -54.1, -37.9 in-in in 8.252 Saltbr-in 2.749 HRD-in -77.73, -45.36 66.12, 18.38 in-in-out SNCiio in-out ActLoopNT-in 3.138 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -130.48, 142.85 APE9-dihe-na -72.74, -170.17 APE8-dihe-in -68.28, 136.12 APE8-rot-in 330.15 APE67-dihe-in -69.45, -7.96 -67.67, -44.97 APE12-dist-in 10.899 APE11-dist-out 5.945 APE10-dist-out 10.093 APE9-dist-in 4.099 None None None XRAY 2.95 0.244 0.289 A 271 258 13 0 0 8 [[678, 938]] 1.0 5up3 STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5V19A 671 939 1374.0 8V4:1000 Type1 Inactive DFGin 6.771 13.638 BLAminus -132.57, 160.59 69.04, 95.45 -107.1, 23.8 302.48, 89.72 -68.71, -20.94 in-in in 8.863 Saltbr-in 2.938 HRD-in -85.68, -36.78 73.98, -9.49 in-in-out SNCiio in-out ActLoopNT-in 3.324 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.73, 133.17 APE9-dihe-na -80.05, -161.91 APE8-dihe-in -68.3, 136.17 APE8-rot-in 312.97 APE67-dihe-in -77.38, -19.64 -51.76, -48.3 APE12-dist-in 10.94 APE11-dist-out 5.65 APE10-dist-out 9.935 APE9-dist-in 4.11 None None None XRAY 3.1 0.24 0.285 A 271 250 19 0 0 8 [[678, 938]] 1.0 5v19 STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5V19B 670 940 1374.0 8V4:1000 Type1 Inactive DFGin 6.938 13.448 BLAminus -112.09, 157.87 57.47, 105.0 -111.04, 30.03 305.07, 81.48 -71.73, -31.06 in-in in 8.592 Saltbr-in 2.557 HRD-in -80.87, -49.12 78.13, 3.37 in-in-out SNCiio in-out ActLoopNT-in 3.042 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -137.42, 143.7 APE9-dihe-na -80.99, -172.63 APE8-dihe-in -58.34, 134.74 APE8-rot-in 315.96 APE67-dihe-in -73.15, -18.54 -59.0, -41.5 APE12-dist-in 11.25 APE11-dist-out 5.956 APE10-dist-out 9.973 APE9-dist-in 4.033 None None None XRAY 3.1 0.24 0.285 B 271 260 11 0 0 6 [[678, 938]] 1.0 5v19 STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5V24A 671 939 1374.0 8V7:1000 Type1 Inactive DFGin 6.444 13.822 BLAminus -138.79, 167.29 63.07, 92.92 -98.6, 22.14 301.17, 102.16 -63.35, -34.76 in-in in 8.552 Saltbr-in 2.654 HRD-in -79.39, -51.03 79.68, 9.93 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -142.07, 141.87 APE9-dihe-na -76.32, -161.06 APE8-dihe-in -57.75, 128.66 APE8-rot-in 314.65 APE67-dihe-in -85.33, 2.43 -49.1, -51.24 APE12-dist-none 999.0 APE11-dist-out 7.359 APE10-dist-out 10.573 APE9-dist-in 4.031 None None None XRAY 2.5 0.236 0.266 A 271 249 20 0 0 9 [[678, 938]] 1.0 5v24 STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5V24B 670 940 1374.0 8V7:1000 Type1 Inactive DFGin 6.686 13.947 BLAminus -131.97, 172.62 55.9, 93.07 -102.8, 24.69 298.12, 84.91 -61.85, -39.9 in-in in 8.482 Saltbr-in 2.679 HRD-in -70.58, -49.83 74.61, 10.19 in-in-out SNCiio in-out ActLoopNT-in 3.126 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -138.19, 141.87 APE9-dihe-na -76.77, -161.96 APE8-dihe-in -77.94, 133.6 APE8-rot-in 312.69 APE67-dihe-in -60.64, -16.25 -59.43, -53.7 APE12-dist-in 10.407 APE11-dist-out 5.924 APE10-dist-out 9.934 APE9-dist-in 3.922 None None None XRAY 2.5 0.236 0.266 B 271 263 8 0 0 8 [[678, 938]] 1.0 5v24 STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
3VW6A 671 939 1374.0 IM6:1001 Type1 Inactive DFGin 6.766 13.694 BLAminus -134.4, 159.82 63.61, 96.18 -106.08, 19.14 299.77, 93.59 -65.67, -26.71 in-in in 8.348 Saltbr-in 2.744 HRD-in -68.63, -53.22 81.29, -1.87 in-in-out SNCiio in-out ActLoopNT-in 2.998 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -141.75, 135.33 APE9-dihe-na -74.82, -165.45 APE8-dihe-in -69.97, 129.12 APE8-rot-in 307.72 APE67-dihe-in -79.01, -8.94 -54.17, -44.62 APE12-dist-in 11.532 APE11-dist-out 5.609 APE10-dist-out 9.737 APE9-dist-in 3.76 None None None XRAY 2.4 0.215 0.252 A 269 255 14 0 0 8 [[678, 938]] 1.0 3vw6 STE_MAP3K5_HUMAN STE 4.3e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
3VW6B 671 939 1374.0 IM6:1001 Type1 Inactive DFGin 6.473 13.757 BLAminus -134.33, 172.21 68.61, 93.15 -105.24, 21.46 296.68, 86.91 -65.52, -28.46 in-in in 8.526 Saltbr-in 2.628 HRD-in -73.34, -41.76 69.65, 0.5 in-in-out SNCiio in-out ActLoopNT-in 2.951 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 138.85 APE9-dihe-na -88.87, -154.31 APE8-dihe-in -65.66, 132.6 APE8-rot-in 313.09 APE67-dihe-in -73.68, -9.35 -60.99, -45.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.322 APE9-dist-in 4.141 None None None XRAY 2.4 0.215 0.252 B 269 253 16 0 0 10 [[678, 938]] 1.0 3vw6 STE_MAP3K5_HUMAN STE 4.3e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5UORA 671 939 1374.0 8GV:1002 Type1 Inactive DFGin 6.285 13.634 BLAminus -134.65, 172.67 64.32, 97.84 -109.08, 20.19 301.0, 92.78 -63.64, -23.3 in-in in 8.61 Saltbr-in 2.949 HRD-in -71.8, -45.36 73.85, 8.78 in-in-out SNCiio in-out ActLoopNT-in 2.826 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -118.5, 140.85 APE9-dihe-na -76.55, -167.59 APE8-dihe-in -50.1, 126.77 APE8-rot-in 307.11 APE67-dihe-in -83.03, -7.05 -61.2, -41.39 APE12-dist-none 999.0 APE11-dist-out 7.181 APE10-dist-out 10.383 APE9-dist-in 4.126 None None None XRAY 2.75 0.205 0.267 A 270 249 20 0 0 9 [[678, 938]] 1.0 5uor STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5UORB 670 939 1374.0 8GV:1002 Type1 Inactive DFGin 6.75 13.91 BLAminus -134.49, 175.22 58.2, 82.47 -94.06, 20.8 300.48, 89.65 -68.28, -20.03 in-in in 8.28 Saltbr-in 2.724 HRD-in -77.75, -45.92 73.94, 0.98 in-in-out SNCiio in-out ActLoopNT-in 3.374 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -135.92, 146.73 APE9-dihe-na -84.86, -151.59 APE8-dihe-in -81.41, 127.68 APE8-rot-in 321.22 APE67-dihe-in -73.68, -9.98 -53.85, -46.25 APE12-dist-in 10.191 APE11-dist-out 6.107 APE10-dist-out 10.046 APE9-dist-in 3.92 None None None XRAY 2.75 0.205 0.267 B 270 262 8 0 0 8 [[678, 938]] 1.0 5uor STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5VILA 670 940 1374.0 9E1:1001 Type1 Inactive DFGin 6.933 13.736 BLAminus -129.43, 176.25 60.35, 85.87 -93.88, 20.78 296.68, 103.23 -63.59, -38.71 in-in in 8.355 Saltbr-in 2.688 HRD-in -75.14, -44.27 72.6, -5.11 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -143.33, 133.88 APE9-dihe-na -70.29, -167.94 APE8-dihe-in -59.8, 126.12 APE8-rot-in 306.7 APE67-dihe-in -62.88, -21.68 -55.02, -48.15 APE12-dist-in 10.92 APE11-dist-out 5.948 APE10-dist-out 10.119 APE9-dist-in 3.815 None None None XRAY 2.64 0.182 0.213 A 293 271 0 0 0 0 [[678, 938]] 1.0 5vil STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5VILB 670 940 1374.0 9E1:1001 Type1 Inactive DFGin 6.913 13.674 BLAminus -121.19, 167.94 68.48, 86.11 -93.27, 20.53 296.7, 102.83 -62.35, -37.98 in-in in 8.318 Saltbr-in 2.667 HRD-in -70.92, -45.87 72.04, -5.16 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -141.25, 132.0 APE9-dihe-na -63.72, -152.68 APE8-dihe-in -74.74, 128.19 APE8-rot-in 305.46 APE67-dihe-in -63.18, -22.1 -55.97, -47.17 APE12-dist-in 11.048 APE11-dist-out 5.867 APE10-dist-out 9.963 APE9-dist-in 3.792 None None None XRAY 2.64 0.182 0.213 B 293 271 0 0 0 0 [[678, 938]] 1.0 5vil STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5VILD 670 940 1374.0 9E1:4000 Type1 Inactive DFGin 6.779 13.613 BLAminus -128.96, 165.86 71.52, 86.1 -95.58, 18.32 298.51, 100.04 -52.66, -47.62 in-in in 7.954 Saltbr-in 2.809 HRD-in -73.79, -44.06 70.88, -5.49 in-in-out SNCiio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -141.86, 132.52 APE9-dihe-na -65.19, -151.72 APE8-dihe-in -74.93, 128.69 APE8-rot-in 307.23 APE67-dihe-in -63.61, -21.82 -53.86, -49.12 APE12-dist-in 10.493 APE11-dist-out 5.673 APE10-dist-out 10.159 APE9-dist-in 3.849 None None None XRAY 2.64 0.182 0.213 D 293 271 0 0 0 0 [[678, 938]] 1.0 5vil STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5VIOA 670 940 1374.0 9E4:4000 Type1 Inactive DFGin 6.963 13.857 BLAminus -120.46, 173.33 58.3, 94.09 -102.99, 24.25 296.09, 98.08 -66.08, -35.82 in-in in 8.414 Saltbr-in 2.745 HRD-in -74.97, -41.99 72.76, -8.55 in-in-out SNCiio in-out ActLoopNT-in 2.824 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -143.49, 136.16 APE9-dihe-na -74.12, -165.55 APE8-dihe-in -61.09, 127.54 APE8-rot-in 313.48 APE67-dihe-in -63.75, -24.16 -54.98, -45.49 APE12-dist-in 10.763 APE11-dist-out 5.915 APE10-dist-out 9.968 APE9-dist-in 3.914 None None None XRAY 2.84 0.181 0.216 A 293 271 0 0 0 0 [[678, 938]] 1.0 5vio STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5VIOB 670 940 1374.0 9E4:4000 Type1 Inactive DFGin 6.797 13.686 BLAminus -122.07, 170.59 66.33, 91.8 -101.04, 21.2 296.32, 98.87 -63.35, -42.36 in-in in 8.307 Saltbr-in 2.736 HRD-in -72.93, -48.35 79.14, -10.27 in-in-out SNCiio in-out ActLoopNT-in 2.786 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -138.69, 137.19 APE9-dihe-na -68.58, -161.75 APE8-dihe-in -67.24, 126.86 APE8-rot-in 310.59 APE67-dihe-in -63.64, -24.3 -54.0, -45.67 APE12-dist-in 10.997 APE11-dist-out 5.739 APE10-dist-out 9.813 APE9-dist-in 3.922 None None None XRAY 2.84 0.181 0.216 B 293 271 0 0 0 0 [[678, 938]] 1.0 5vio STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5VIOD 670 940 1374.0 9E4:4000 Type1 Inactive DFGin 6.729 13.751 BLAminus -125.66, 172.5 64.37, 91.94 -102.27, 19.02 296.92, 97.46 -79.31, 7.01 in-in in 8.464 Saltbr-in 2.794 HRD-in -62.69, -41.35 70.75, -12.73 in-in-out SNCiio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -145.74, 135.42 APE9-dihe-na -73.58, -160.05 APE8-dihe-in -65.52, 127.14 APE8-rot-in 313.58 APE67-dihe-in -64.57, -23.44 -53.04, -46.36 APE12-dist-in 11.116 APE11-dist-out 5.838 APE10-dist-out 9.692 APE9-dist-in 4.01 None None None XRAY 2.84 0.181 0.216 D 293 271 0 0 0 0 [[678, 938]] 1.0 5vio STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6XIHA 671 940 1374.0 V3S:1000 Type1 Inactive DFGin 6.699 13.935 BLAminus -124.24, 171.43 62.39, 90.11 -100.17, 18.2 296.55, 92.58 -52.23, -40.83 in-in in 8.395 Saltbr-in 2.71 HRD-in -75.25, -49.42 79.66, 5.85 in-in-out SNCiio in-out ActLoopNT-in 3.176 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -129.36, 154.65 APE9-dihe-na -92.62, -162.28 APE8-dihe-in -70.59, 130.07 APE8-rot-in 331.74 APE67-dihe-in -62.68, -15.95 -64.17, -51.46 APE12-dist-in 10.956 APE11-dist-out 5.963 APE10-dist-out 10.005 APE9-dist-in 3.931 None None None XRAY 2.65 0.228 0.292 A 295 258 12 0 0 8 [[678, 938]] 1.0 6xih STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6XIHB 671 939 1374.0 V3S:1000 Type1 Inactive DFGin 6.609 13.675 BLAminus -132.91, 163.64 66.06, 96.79 -103.4, 13.78 297.24, 111.79 -55.47, -33.38 in-in in 8.67 Saltbr-in 2.666 HRD-in -84.49, -53.59 86.87, -13.44 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 156.58 APE8-dihe-in -52.99, 137.0 APE8-rot-out 62.22 APE67-dihe-in -90.67, 5.14 -61.89, -43.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.132 None None None XRAY 2.65 0.228 0.292 B 295 246 23 0 0 12 [[678, 938]] 1.0 6xih STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6E2MB 671 940 1374.0 KK7:1001 Type1 Inactive DFGin 6.519 13.69 BLAminus -124.37, 175.44 61.51, 85.57 -96.57, 16.8 298.76, 85.53 -59.98, -32.28 in-in in 8.194 Saltbr-in 2.519 HRD-in -74.6, -57.55 88.85, -0.31 in-in-out SNCiio in-out ActLoopNT-in 3.048 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 92.46 APE9-dihe-na -97.99, -118.26 APE8-dihe-in -118.56, 131.17 APE8-rot-in 295.79 APE67-dihe-in -69.37, -11.46 -56.54, -49.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.386 APE9-dist-in 3.765 None TPO838 TPO838 XRAY 2.253 0.218 0.259 B 295 248 22 0 0 10 [[678, 938]] 1.0 6e2m STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6E2OB 671 939 1374.0 S0L:1001 Type1 Inactive DFGin 6.455 14.013 BLAminus -123.87, 176.77 53.57, 98.76 -104.53, 24.03 295.0, 85.92 -63.99, -37.99 in-in in 8.498 Saltbr-in 2.237 HRD-in -70.67, -52.1 75.95, 3.25 in-in-out SNCiio in-out ActLoopNT-in 3.062 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 132.02 APE9-dihe-na -86.03, -126.81 APE8-dihe-in -106.63, 130.74 APE8-rot-in 293.08 APE67-dihe-in -80.88, 1.52 -56.21, -44.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.61 APE9-dist-in 3.585 None TPO838 TPO838 XRAY 2.389 0.217 0.268 B 295 250 19 0 0 10 [[678, 938]] 1.0 6e2o STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6VREA 671 940 1374.0 RFG:1002 Type1 Inactive DFGin 6.815 13.611 BLAminus -129.9, 174.85 60.66, 96.18 -107.07, 14.48 299.67, 100.35 -66.93, -27.63 in-in in 8.337 Saltbr-in 2.698 HRD-in -75.62, -47.02 73.48, 5.8 in-in-out SNCiio in-out ActLoopNT-in 3.082 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.85, 140.4 APE9-dihe-na -80.98, -165.5 APE8-dihe-in -71.42, 135.62 APE8-rot-in 312.64 APE67-dihe-in -74.41, -14.28 -63.87, -41.58 APE12-dist-in 10.791 APE11-dist-out 5.429 APE10-dist-out 9.876 APE9-dist-in 3.7 None None None XRAY 2.29 0.19 0.24 A 291 261 9 0 0 7 [[678, 938]] 1.0 6vre STE_MAP3K5_HUMAN STE 1.2e-80 276.7 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6VREB 669 940 1374.0 RFG:1001 Type1 Inactive DFGin 6.49 14.012 BLAminus -129.48, 175.2 61.52, 95.42 -105.05, 19.46 294.04, 89.61 -65.54, -30.46 in-in in 8.749 Saltbr-in 2.576 HRD-in -76.83, -46.56 70.39, 7.92 in-in-out SNCiio in-out ActLoopNT-in 3.122 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 135.01 APE9-dihe-na -90.36, -169.74 APE8-dihe-in -80.73, 139.41 APE8-rot-out 88.48 APE67-dihe-in -72.31, -15.25 -63.35, -40.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.556 APE9-dist-in 3.709 None None None XRAY 2.29 0.19 0.24 B 291 260 12 0 0 8 [[678, 938]] 1.0 6vre STE_MAP3K5_HUMAN STE 1.2e-80 276.7 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6OYWB 671 940 1374.0 NKJ:1001 Type1 Inactive DFGin 6.69 13.868 BLAminus -122.51, 166.6 60.27, 92.71 -105.19, 18.97 297.73, 95.21 -67.14, -20.88 in-in in 8.573 Saltbr-in 2.696 HRD-in -76.18, -44.1 70.51, 11.85 in-in-out SNCiio in-out ActLoopNT-in 3.186 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 104.69 APE9-dihe-na -71.78, -150.4 APE8-dihe-in -87.95, 134.15 APE8-rot-in 310.76 APE67-dihe-in -70.38, -10.89 -59.89, -50.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.132 APE9-dist-in 3.937 T838E None None XRAY 2.603 0.21 0.255 B 294 256 14 0 0 10 [[678, 938]] 1.0 6oyw STE_MAP3K5_HUMAN STE 1.2e-80 276.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6OYWC 671 939 1374.0 NKJ:1001 Type1 Inactive DFGin 6.822 14.194 BLAminus -125.99, 170.88 63.72, 91.25 -105.44, 18.69 294.07, 95.01 -66.78, -18.88 in-in in 8.829 Saltbr-in 2.614 HRD-in -80.6, -45.91 69.98, 10.62 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -133.5, 148.17 APE9-dihe-na -70.3, -155.77 APE8-dihe-in -88.98, 138.74 APE8-rot-out 85.39 APE67-dihe-in -67.74, -14.04 -56.79, -47.02 APE12-dist-in 10.985 APE11-dist-out 6.032 APE10-dist-out 10.236 APE9-dist-in 3.675 T838E None None XRAY 2.603 0.21 0.255 C 294 260 9 0 0 5 [[678, 938]] 1.0 6oyw STE_MAP3K5_HUMAN STE 1.2e-80 276.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BIBA 670 939 1374.0 IEO:1940 Type1 Inactive DFGin 6.89 13.685 BLAminus -101.96, 171.68 56.63, 96.52 -108.09, 9.31 305.46, 105.24 -97.03, 34.5 out-out out 10.328 Saltbr-out 7.92 HRD-in -62.68, -55.31 79.51, -12.34 out-in-out SNCoio in-out ActLoopNT-in 3.05 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.73, 130.88 APE9-dihe-na -70.59, -168.47 APE8-dihe-in -67.53, 132.39 APE8-rot-in 314.8 APE67-dihe-in -64.88, -13.63 -56.67, -50.04 APE12-dist-in 10.466 APE11-dist-out 5.099 APE10-dist-out 9.673 APE9-dist-in 3.448 T838E None None XRAY 2.43 0.203 0.239 A 318 254 16 0 0 8 [[678, 938]] 1.0 4bib STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BIBB 670 940 1374.0 IEO:1941 Type1 Inactive DFGin 6.831 14.076 BLAminus -122.95, 179.25 61.68, 85.04 -100.41, 15.31 300.43, 103.7 -75.4, -20.2 in-out in 9.316 Saltbr-out 3.868 HRD-in -65.57, -43.92 69.2, -4.11 out-in-out SNCoio in-out ActLoopNT-in 2.937 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -130.37, 121.6 APE9-dihe-na -77.09, -118.37 APE8-dihe-in -118.52, 124.53 APE8-rot-in 308.41 APE67-dihe-in -63.49, -22.1 -41.53, -59.58 APE12-dist-none 999.0 APE11-dist-out 6.717 APE10-dist-out 9.995 APE9-dist-in 3.718 T838E None None XRAY 2.43 0.203 0.239 B 318 258 13 0 0 9 [[678, 938]] 1.0 4bib STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BICA 670 940 1374.0 IE4:1 Type1 Inactive DFGin 7.014 13.672 BLAminus -101.38, -174.95 48.39, 111.02 -118.16, 17.14 290.62, 103.28 -72.3, -34.21 out-out out 10.422 Saltbr-out 7.556 HRD-in -64.29, -55.3 81.29, -4.92 out-in-out SNCoio in-out ActLoopNT-in 3.178 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.95, 136.62 APE9-dihe-na -70.67, -159.58 APE8-dihe-in -81.37, 127.16 APE8-rot-in 311.94 APE67-dihe-in -65.51, -3.48 -48.39, -54.68 APE12-dist-in 11.181 APE11-dist-out 5.628 APE10-dist-out 9.712 APE9-dist-in 3.469 T838E None None XRAY 2.62 0.209 0.265 A 318 260 11 0 0 6 [[678, 938]] 1.0 4bic STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BIDA 670 939 1374.0 IE8:4000 Type1 Inactive DFGin 7.683 14.817 BLAminus -102.49, -169.5 32.62, 94.58 -110.23, 27.35 288.25, 85.03 -82.81, -25.67 in-out in 9.896 Saltbr-out 8.838 HRD-in -80.59, -44.06 71.64, -12.71 out-in-out SNCoio in-out ActLoopNT-in 3.212 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.03, 154.58 APE9-dihe-na -83.3, -134.14 APE8-dihe-in -115.1, 122.45 APE8-rot-in 304.44 APE67-dihe-in -76.51, -1.93 -39.2, -49.34 APE12-dist-in 10.168 APE11-dist-out 5.585 APE10-dist-out 9.425 APE9-dist-in 3.522 T838E None None XRAY 2.8 0.196 0.259 A 318 254 16 0 0 8 [[678, 938]] 1.0 4bid STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BIDB 670 940 1374.0 IE8:4000 Type1 Inactive DFGin 7.305 14.814 BLAminus -128.81, -175.28 60.09, 79.34 -98.8, 16.39 285.54, 85.11 -71.67, -26.71 in-in in 8.688 Saltbr-in 3.005 HRD-in -85.3, -31.09 65.9, -13.52 in-in-out SNCiio in-out ActLoopNT-in 3.219 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -142.53, 121.12 APE9-dihe-na -74.7, -130.34 APE8-dihe-in -116.64, 122.41 APE8-rot-in 302.24 APE67-dihe-in -59.91, -43.52 -38.81, -52.5 APE12-dist-none 999.0 APE11-dist-out 7.301 APE10-dist-out 9.761 APE9-dist-in 3.542 T838E None None XRAY 2.8 0.196 0.259 B 318 258 13 0 0 9 [[678, 938]] 1.0 4bid STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BIEA 670 940 1374.0 IE6:1942 Type1 Inactive DFGin 6.625 13.335 BLAminus -106.98, -175.45 45.85, 99.41 -108.71, 17.72 301.37, 101.11 -72.7, -39.67 in-in in 8.47 Saltbr-in 2.948 HRD-in -68.25, -48.97 78.37, -0.9 in-in-out SNCiio in-out ActLoopNT-in 3.202 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.69, 130.25 APE9-dihe-na -69.58, -174.96 APE8-dihe-in -63.32, 129.38 APE8-rot-in 309.24 APE67-dihe-in -64.21, -7.52 -51.07, -54.4 APE12-dist-in 10.792 APE11-dist-out 5.249 APE10-dist-out 9.422 APE9-dist-in 3.381 T838E None None XRAY 2.36 0.212 0.253 A 318 257 14 0 0 6 [[678, 938]] 1.0 4bie STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BIEB 670 941 1374.0 IE6:1943 Type1 Inactive DFGin 6.549 13.473 BLAminus -114.43, 179.36 48.03, 98.73 -110.34, 26.8 303.44, 92.42 -71.11, -34.15 in-in in 8.588 Saltbr-in 3.013 HRD-in -66.09, -44.17 66.71, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.98, 115.45 APE9-dihe-na -86.27, -157.16 APE8-dihe-in -81.66, 117.27 APE8-rot-in 313.7 APE67-dihe-in -62.93, -22.85 -39.01, -55.55 APE12-dist-none 999.0 APE11-dist-out 6.99 APE10-dist-out 9.921 APE9-dist-in 4.088 T838E None None XRAY 2.36 0.212 0.253 B 318 257 15 0 0 8 [[678, 938]] 1.0 4bie STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BF2A 671 939 1374.0 STU:1940 Type1 Inactive DFGin 7.213 13.807 BLAminus -114.3, -178.78 51.44, 86.67 -90.54, 15.85 294.66, 96.8 -75.78, -2.2 out-none out 10.049 Saltbr-none 999.0 HRD-in -67.79, -49.78 78.33, -4.9 none-in-out SNCnio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.2, 134.23 APE9-dihe-na -68.74, -169.24 APE8-dihe-in -70.38, 133.03 APE8-rot-in 304.95 APE67-dihe-in -66.2, -12.84 -50.6, -52.99 APE12-dist-in 11.059 APE11-dist-out 5.44 APE10-dist-out 9.736 APE9-dist-in 3.512 T838E None None XRAY 2.11 0.208 0.247 A 334 253 16 0 0 6 [[678, 938]] 1.0 4bf2 STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BF2B 671 940 1374.0 STU:1941 Type1 Inactive DFGin 6.92 13.803 BLAminus -128.63, -177.63 56.0, 77.77 -86.85, 11.45 292.4, 104.75 -69.02, -19.49 in-none in 9.74 Saltbr-none 999.0 HRD-in -67.52, -45.29 72.76, -9.25 none-in-out SNCnio in-out ActLoopNT-in 3.012 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 145.57 APE9-dihe-na -77.44, -148.98 APE8-dihe-in -83.86, 130.43 APE8-rot-in 307.99 APE67-dihe-in -59.87, -30.7 -43.72, -58.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.696 APE9-dist-in 3.527 T838E None None XRAY 2.11 0.208 0.247 B 334 252 18 0 0 9 [[678, 938]] 1.0 4bf2 STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BHNA 670 940 1374.0 BH9:1 Type1 Inactive DFGin 6.641 13.419 BLAminus -116.15, 170.7 61.91, 107.63 -114.13, 14.36 294.82, 100.14 -70.55, -20.89 in-in in 8.61 Saltbr-in 2.802 HRD-in -66.8, -54.62 82.11, -4.15 in-in-out SNCiio in-out ActLoopNT-in 3.244 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.48, 131.86 APE9-dihe-na -68.23, -173.64 APE8-dihe-in -65.87, 129.94 APE8-rot-in 307.79 APE67-dihe-in -62.92, -9.87 -53.4, -53.13 APE12-dist-in 10.033 APE11-dist-out 5.14 APE10-dist-out 9.619 APE9-dist-in 3.441 T838E None None XRAY 2.3 0.197 0.235 A 334 256 15 0 0 8 [[678, 938]] 1.0 4bhn STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
4BHNB 670 938 1374.0 BH9:1 Type1 Inactive DFGin 6.663 13.551 BLAminus -127.02, 174.96 58.51, 91.28 -97.83, 21.74 301.12, 94.31 -63.02, -40.41 in-in in 8.459 Saltbr-in 2.595 HRD-in -66.57, -49.23 72.07, 1.38 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -134.18, 113.64 APE9-dihe-na -75.96, -135.55 APE8-dihe-in -93.54, 117.0 APE8-rot-in 314.59 APE67-dihe-in -59.83, -23.07 -45.36, -57.56 APE12-dist-none 999.0 APE11-dist-out 6.948 APE10-dist-out 10.229 APE9-dist-in 4.249 T838E None None XRAY 2.3 0.197 0.235 B 334 257 12 0 0 8 [[678, 938]] 1.0 4bhn STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
7MU6A 671 939 1374.0 A1AWT:1001 Type1 Inactive DFGin 6.806 13.81 BLAminus -134.71, 172.36 55.8, 97.35 -103.45, 21.85 298.86, 96.76 -71.3, -26.18 in-in in 8.335 Saltbr-in 2.513 HRD-in -80.43, -45.88 78.17, 0.0 in-in-out SNCiio in-out ActLoopNT-in 3.129 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -110.25, 144.39 APE9-dihe-na -81.83, -163.92 APE8-dihe-in -76.49, 135.89 APE8-rot-in 306.21 APE67-dihe-in -72.49, -10.64 -62.48, -45.91 APE12-dist-in 10.534 APE11-dist-out 5.142 APE10-dist-out 9.751 APE9-dist-in 3.698 None None None XRAY 2.165 0.191 0.214 A 334 259 10 0 0 7 [[678, 938]] 1.0 7mu6 STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
7MU7A 671 940 1374.0 RFG:1003 Type1 Inactive DFGin 6.757 13.715 BLAminus -136.15, -179.86 56.07, 94.54 -107.99, 16.99 301.26, 96.73 -67.77, -29.01 in-in in 8.381 Saltbr-in 2.688 HRD-in -75.3, -47.48 74.9, 5.08 in-in-out SNCiio in-out ActLoopNT-in 3.099 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.97, 138.28 APE9-dihe-na -81.33, -164.64 APE8-dihe-in -73.3, 130.4 APE8-rot-in 314.02 APE67-dihe-in -72.58, -18.66 -57.86, -41.71 APE12-dist-in 10.763 APE11-dist-out 5.421 APE10-dist-out 9.886 APE9-dist-in 3.66 None None None XRAY 2.298 0.207 0.242 A 334 263 7 0 0 7 [[678, 938]] 1.0 7mu7 STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
7MU7B 669 940 1374.0 RFG:1003 Type1 Inactive DFGin 6.456 14.084 BLAminus -133.69, 179.33 55.17, 97.63 -107.16, 19.31 292.8, 94.2 -66.83, -32.31 in-in in 8.714 Saltbr-in 2.699 HRD-in -75.96, -46.83 74.41, 6.4 in-in-out SNCiio in-out ActLoopNT-in 3.098 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 134.07 APE9-dihe-na -87.4, -167.12 APE8-dihe-in -77.87, 130.78 APE8-rot-in 312.34 APE67-dihe-in -72.25, -17.64 -58.41, -40.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.498 APE9-dist-in 3.558 None None None XRAY 2.298 0.207 0.242 B 334 260 12 0 0 8 [[678, 938]] 1.0 7mu7 STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5VIOC 670 940 1374.0 No_ligand No_ligand Inactive DFGin 6.357 13.825 None -118.22, -166.23 70.4, -83.21 71.44, -145.78 303.48, 97.0 79.63, -42.0 in-in in 8.384 Saltbr-in 2.948 HRD-in -67.24, -40.33 70.79, -6.68 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -146.22, 135.17 APE9-dihe-na -72.34, -160.36 APE8-dihe-in -65.61, 126.24 APE8-rot-in 312.24 APE67-dihe-in -64.54, -23.72 -53.71, -45.87 APE12-dist-in 10.919 APE11-dist-out 5.816 APE10-dist-out 9.827 APE9-dist-in 3.919 None None None XRAY 2.84 0.181 0.216 C 293 271 0 0 0 0 [[678, 938]] 1.0 5vio STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5VILC 670 940 1374.0 9E1:4000 Type1 Inactive DFGin 6.681 13.665 None -127.14, -166.22 81.0, -82.49 64.22, -158.94 310.26, 99.86 83.75, -48.04 in-in in 8.387 Saltbr-in 2.767 HRD-in -62.04, -44.3 71.5, -5.97 in-in-out SNCiio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -142.26, 132.14 APE9-dihe-na -63.89, -152.16 APE8-dihe-in -75.62, 128.61 APE8-rot-in 305.72 APE67-dihe-in -63.56, -22.05 -54.79, -48.45 APE12-dist-in 10.794 APE11-dist-out 5.814 APE10-dist-out 9.964 APE9-dist-in 3.826 None None None XRAY 2.64 0.182 0.213 C 293 271 0 0 0 0 [[678, 938]] 1.0 5vil STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
2CLQA 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 5.918 8.469 BABtrans -91.39, 129.8 -141.56, 7.65 -79.81, 110.16 226.87, 94.37 134.88, -46.11 out-out out 10.127 Saltbr-out 4.796 HRD-in -81.27, -49.85 78.55, 0.8 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -136.64, 134.41 APE9-dihe-na -79.2, -159.26 APE8-dihe-in -79.76, 137.19 APE8-rot-in 323.06 APE67-dihe-in -73.67, -16.9 -62.96, -40.27 APE12-dist-in 11.61 APE11-dist-out 6.223 APE10-dist-out 10.04 APE9-dist-in 3.702 None None None XRAY 2.3 0.204 0.257 A 295 263 8 0 0 5 [[678, 938]] 1.0 2clq STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
2CLQB 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 6.564 8.021 BABtrans -97.55, 126.7 -140.68, 10.18 -79.54, 109.54 215.05, 109.45 130.73, -46.4 in-none in 9.98 Saltbr-none 999.0 HRD-in -83.48, -49.36 79.39, -1.77 none-in-out SNCnio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.24, 136.94 APE9-dihe-na -82.54, -165.1 APE8-dihe-in -71.26, 138.19 APE8-rot-in 313.5 APE67-dihe-in -70.89, -23.23 -61.89, -43.74 APE12-dist-none 999.0 APE11-dist-out 6.267 APE10-dist-out 10.013 APE9-dist-in 3.749 None None None XRAY 2.3 0.204 0.257 B 295 259 12 0 0 8 [[678, 938]] 1.0 2clq STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
8QGYA 95 940 1374.0 No_ligand No_ligand Inactive DFGout 12.319 7.832 None -113.17, 136.85 -125.29, 138.85 -124.85, 84.07 305.69, 87.83 61.56, 19.79 in-out in 7.925 Saltbr-out 6.419 HRD-out -77.96, 140.03 -109.85, 144.64 out-in-none SNCoin in-none ActLoopNT-in 2.987 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -38.63 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.71 999.0 999.0 A 896 780 33 0 0 13 [[678, 938]] 1.0 8qgy STE_MAP3K5_HUMAN STE 1.1e-79 273.9 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6OYTA 667 939 1374.0 NJV:61001 Type1 None DFGin 5.681 13.351 BLAminus -125.18, 173.88 59.78, 86.22 -94.31, 25.78 300.06, 101.7 -62.97, -32.35 in-in in 8.832 Saltbr-in 2.26 HRD-in -73.98, -49.46 76.75, 0.8 in-in-none SNCiin in-none ActLoopNT-in 2.979 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.824 0.235 0.29 A 280 221 52 0 0 20 [[678, 938]] 1.0 6oyt STE_MAP3K5_HUMAN STE 5e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6OYTC 671 938 1374.0 NJV:61001 Type1 None DFGin 6.079 13.489 BLAminus -119.54, 172.14 56.5, 86.88 -93.47, 25.36 302.99, 99.79 -64.69, -32.12 in-in in 8.321 Saltbr-in 2.529 HRD-in -71.89, -48.46 74.08, 0.71 in-in-none SNCiin in-none ActLoopNT-in 3.275 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.69, -21.53 999.0, -119.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.824 0.235 0.29 C 280 236 32 0 0 13 [[678, 938]] 1.0 6oyt STE_MAP3K5_HUMAN STE 5e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6OYTD 667 939 1374.0 NJV:61002 Type1 None DFGin 5.873 13.601 BLAminus -124.35, 174.62 60.77, 86.25 -96.47, 25.37 301.41, 82.49 -61.64, -30.64 in-in in 9.067 Saltbr-in 2.509 HRD-in -72.35, -49.7 75.51, 0.65 in-in-none SNCiin in-none ActLoopNT-in 2.818 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -134.49 APE8-dihe-in -107.42, 132.24 APE8-rot-in 319.21 APE67-dihe-in -73.68, -28.35 -46.85, -37.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.788 None None None XRAY 2.824 0.235 0.29 D 280 250 23 0 0 10 [[678, 938]] 1.0 6oyt STE_MAP3K5_HUMAN STE 5e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
5UP3B 671 939 1374.0 8GS:1000 Type1 None DFGin 6.404 13.522 BLAminus -145.21, 155.75 74.64, 95.67 -108.04, 14.34 302.59, 105.08 -64.34, -17.97 in-in in 8.566 Saltbr-in 2.91 HRD-in -87.24, -40.99 75.36, -9.84 in-in-none SNCiin in-none ActLoopNT-in 3.023 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.91 APE8-dihe-in -57.21, 126.4 APE8-rot-in 314.64 APE67-dihe-in -121.68, -3.36 -59.97, -11.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.493 None None None XRAY 2.95 0.244 0.289 B 271 243 26 0 0 11 [[678, 938]] 1.0 5up3 STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
6E2NB 670 939 1374.0 KK8:1001 Type1 None DFGin 6.543 13.925 BLAminus -124.43, -172.06 45.44, 94.03 -100.49, 19.41 297.14, 84.65 -62.68, -39.36 in-in in 8.526 Saltbr-in 2.317 HRD-in -77.48, -52.13 80.81, -2.87 in-in-none SNCiin in-none ActLoopNT-in 3.176 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -34.96 APE9-dihe-na 147.14, -170.88 APE8-dihe-in -105.95, 128.57 APE8-rot-in 300.89 APE67-dihe-in -77.71, -0.68 -49.6, -53.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.857 APE9-dist-in 3.588 None TPO838 TPO838 XRAY 2.098 0.217 0.257 B 295 250 20 0 0 10 [[678, 938]] 1.0 6e2n STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
7MU6B 671 940 1374.0 A1AWT:1001 Type1 None DFGin 6.472 13.842 BLAminus -137.24, 175.06 55.73, 97.84 -102.69, 23.8 295.93, 95.1 -68.36, -28.7 in-in in 8.476 Saltbr-in 2.441 HRD-in -80.7, -46.25 77.78, 2.33 in-in-none SNCiin in-none ActLoopNT-in 3.029 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 66.13 APE9-dihe-na -85.74, -166.57 APE8-dihe-in -87.23, 138.03 APE8-rot-in 306.07 APE67-dihe-in -71.64, -12.66 -62.6, -45.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.317 APE9-dist-in 3.356 None None None XRAY 2.165 0.191 0.214 B 334 261 9 0 0 9 [[678, 938]] 1.0 7mu6 STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5

STE_MAP3K5 (Mitogen-activated protein kinase kinase kinase 5)

Total number of chains: 60
Active chains: 7
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 55 91.7% AF-Q99683-K1A
DFGin None 2 3.3% 5VILC
DFGinter BABtrans 2 3.3% 2CLQA
DFGout None 1 1.7% 8QGYA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
M3K5_HUMAN AF-Q99683-K1A Q99683 665 946 1374.0 No_ligand No_ligand Active DFGin 6.326 13.78 BLAminus -133.75, 172.68 64.9, 76.7 -86.04, 10.57 296.36, 98.71 -64.02, -18.97 in-in in 9.337 Saltbr-in 2.701 HRD-in -77.78, -42.95 69.92, 5.17 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.49, 155.63 APE9-dihe-na 100.41, 168.83 APE8-dihe-in -83.55, 120.96 APE8-rot-in 306.67 APE67-dihe-in -65.67, -19.75 -47.15, -43.3 APE12-dist-in 10.265 APE11-dist-in 11.013 APE10-dist-in 5.108 APE9-dist-in 3.36 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[678, 938]] 1.0 AF-Q99683-K1 Homo sapiens STE_MAP3K5_HUMAN STE 5.1e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN AF-Q99683-K3A Q99683 665 946 1374.0 No_ligand No_ligand Active DFGin 6.042 13.888 BLAminus -134.38, 174.72 61.46, 77.42 -84.02, 5.96 293.99, 96.53 -62.32, -19.99 in-in in 9.38 Saltbr-in 2.783 HRD-in -79.49, -42.35 71.31, 5.3 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.18, 137.36 APE9-dihe-na 132.62, 179.42 APE8-dihe-in -85.9, 125.24 APE8-rot-in 302.53 APE67-dihe-in -73.41, -15.55 -49.86, -42.6 APE12-dist-in 8.839 APE11-dist-in 11.43 APE10-dist-in 5.685 APE9-dist-in 3.16 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[678, 938]] 1.0 AF-Q99683-K3 Homo sapiens STE_MAP3K5_HUMAN STE 5.1e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6E2MA Q99683 670 939 1374.0 KK7:1001 Type1 Active DFGin 6.484 13.92 BLAminus -132.61, -176.88 59.34, 83.43 -95.61, 21.06 294.64, 87.4 -75.58, -24.51 in-in in 8.322 Saltbr-in 2.707 HRD-in -79.6, -54.85 80.2, -0.99 in-in-in SNCiii in-in ActLoopNT-in 3.018 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.09, 141.28 APE9-dihe-na 137.66, -163.35 APE8-dihe-in -108.24, 127.53 APE8-rot-in 312.25 APE67-dihe-in -79.27, 2.13 -47.64, -50.68 APE12-dist-in 8.661 APE11-dist-in 11.519 APE10-dist-in 5.809 APE9-dist-in 3.647 None TPO838 TPO838 XRAY 2.253 0.218 0.259 A 295 261 9 0 0 3 [[678, 938]] 1.0 6e2m Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6E2NA Q99683 670 939 1374.0 KK8:1001 Type1 Active DFGin 6.585 13.706 BLAminus -128.11, 176.27 63.7, 87.31 -95.72, 18.06 293.79, 96.85 -65.65, -28.4 in-in in 8.496 Saltbr-in 2.424 HRD-in -72.32, -48.31 74.73, -0.84 in-in-in SNCiii in-in ActLoopNT-in 2.841 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.92, 119.98 APE9-dihe-na 157.47, -169.23 APE8-dihe-in -101.35, 128.58 APE8-rot-in 305.37 APE67-dihe-in -74.54, -0.8 -47.59, -53.19 APE12-dist-in 8.975 APE11-dist-in 11.414 APE10-dist-in 5.699 APE9-dist-in 3.768 None TPO838 TPO838 XRAY 2.098 0.217 0.257 A 295 264 6 0 0 3 [[678, 938]] 1.0 6e2n Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6E2OA Q99683 670 939 1374.0 S0L:1001 Type1 Active DFGin 6.427 13.752 BLAminus -130.19, 177.71 63.47, 88.15 -96.82, 15.0 292.86, 87.16 -66.71, -13.24 in-in in 8.417 Saltbr-in 2.331 HRD-in -77.39, -52.31 81.18, -9.05 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.07, 124.52 APE9-dihe-na 152.3, -162.8 APE8-dihe-in -101.88, 129.38 APE8-rot-in 311.55 APE67-dihe-in -83.05, -5.3 -45.17, -51.3 APE12-dist-in 8.972 APE11-dist-in 11.336 APE10-dist-in 5.636 APE9-dist-in 3.631 None TPO838 TPO838 XRAY 2.389 0.217 0.268 A 295 264 6 0 0 4 [[678, 938]] 1.0 6e2o Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6OYWA Q99683 671 939 1374.0 NKJ:1001 Type1 Active DFGin 6.434 14.086 BLAminus -125.84, 170.11 63.72, 92.65 -105.14, 20.43 292.62, 91.43 -65.77, -22.03 in-in in 8.822 Saltbr-in 2.742 HRD-in -80.43, -46.73 68.52, 12.61 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.72, -53.83 APE9-dihe-na -69.9, -156.1 APE8-dihe-in -92.5, 138.42 APE8-rot-in 305.47 APE67-dihe-in -70.77, -12.46 -57.12, -50.56 APE12-dist-in 9.337 APE11-dist-in 11.495 APE10-dist-in 5.773 APE9-dist-in 3.364 T838E None None XRAY 2.603 0.21 0.255 A 294 261 8 0 0 5 [[678, 938]] 1.0 6oyw Homo sapiens STE_MAP3K5_HUMAN STE 1.2e-80 276.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6OYWD Q99683 671 939 1374.0 NKJ:1001 Type1 Active DFGin 6.73 14.1 BLAminus -126.38, 171.59 64.38, 91.17 -105.76, 19.88 291.74, 93.18 -66.55, -21.17 in-in in 8.57 Saltbr-in 2.615 HRD-in -79.44, -46.61 68.22, 12.5 in-in-in SNCiii in-in ActLoopNT-in 3.081 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.59, -53.64 APE9-dihe-na -69.48, -155.47 APE8-dihe-in -94.08, 138.29 APE8-rot-in 307.43 APE67-dihe-in -70.62, -12.36 -58.47, -50.51 APE12-dist-in 9.617 APE11-dist-in 11.18 APE10-dist-in 5.582 APE9-dist-in 3.249 T838E None None XRAY 2.603 0.21 0.255 D 294 260 9 0 0 7 [[678, 938]] 1.0 6oyw Homo sapiens STE_MAP3K5_HUMAN STE 1.2e-80 276.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BICB Q99683 670 941 1374.0 No_ligand No_ligand Inactive DFGin 6.892 13.912 BLAminus -103.89, -176.24 54.3, 109.06 -118.88, 13.34 294.77, 106.96 -69.0, -30.39 out-out out 10.251 Saltbr-out 7.438 HRD-in -71.14, -46.62 71.03, 1.85 out-in-out SNCoio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 134.01 APE9-dihe-na -123.04, -156.14 APE8-dihe-in -74.52, 124.55 APE8-rot-in 316.61 APE67-dihe-in -59.56, -26.48 -42.14, -59.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.018 APE9-dist-in 3.738 T838E None None XRAY 2.62 0.209 0.265 B 318 259 13 0 0 9 [[678, 938]] 1.0 4bic Homo sapiens STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 8QGYB Q99683 95 940 1374.0 No_ligand No_ligand Inactive DFGin 6.296 14.627 BLAminus -118.91, -173.64 60.96, 62.83 -83.04, 12.9 285.27, 91.57 -62.95, -24.83 in-in in 8.379 Saltbr-in 2.291 HRD-in -74.5, -37.2 74.29, -11.41 in-in-out SNCiio in-out ActLoopNT-in 3.027 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.11, 161.15 APE9-dihe-na -126.52, -147.08 APE8-dihe-in -82.32, 141.14 APE8-rot-in 307.49 APE67-dihe-in -70.79, -18.31 -66.98, -41.04 APE12-dist-in 12.334 APE11-dist-out 7.514 APE10-dist-out 9.324 APE9-dist-in 3.926 None None None EM 3.71 999.0 999.0 B 896 809 0 0 0 0 [[678, 938]] 1.0 8qgy Homo sapiens STE_MAP3K5_HUMAN STE 1.1e-79 273.9 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6OYTB Q99683 670 939 1374.0 NJV:61001 Type1 Inactive DFGin 6.064 13.619 BLAminus -123.67, 174.71 58.76, 86.33 -94.62, 25.23 301.23, 87.02 -61.68, -31.79 in-in in 8.433 Saltbr-in 3.107 HRD-in -71.92, -47.68 75.96, 1.56 in-in-out SNCiio in-out ActLoopNT-in 3.076 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -174.48 APE8-dihe-out -87.75, -23.66 APE8-rot-out 185.17 APE67-dihe-in -68.87, -21.84 -52.56, -42.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.264 None None None XRAY 2.824 0.235 0.29 B 280 238 32 0 0 10 [[678, 938]] 1.0 6oyt Homo sapiens STE_MAP3K5_HUMAN STE 5e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5UOXA Q99683 670 940 1374.0 8GY:1000 Type1 Inactive DFGin 6.798 13.988 BLAminus -128.31, 175.13 55.09, 92.72 -100.89, 23.01 297.63, 88.22 -70.07, -26.13 in-in in 8.501 Saltbr-in 2.756 HRD-in -71.84, -50.9 74.59, 7.46 in-in-out SNCiio in-out ActLoopNT-in 3.214 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.88, 138.86 APE9-dihe-na -76.06, -175.52 APE8-dihe-in -63.3, 129.59 APE8-rot-in 321.22 APE67-dihe-in -67.41, -0.83 -64.06, -49.27 APE12-dist-in 10.796 APE11-dist-out 5.516 APE10-dist-out 10.05 APE9-dist-in 3.952 None None None XRAY 2.5 0.229 0.253 A 271 263 8 0 0 8 [[678, 938]] 1.0 5uox Homo sapiens STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5UOXB Q99683 670 939 1374.0 8GY:1000 Type1 Inactive DFGin 6.524 13.816 BLAminus -134.06, 158.99 57.73, 94.5 -98.62, 19.22 300.63, 97.73 -64.04, -32.22 in-in in 8.572 Saltbr-in 2.661 HRD-in -75.21, -51.08 80.04, -0.5 in-in-out SNCiio in-out ActLoopNT-in 3.019 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.94, 128.06 APE9-dihe-na -81.2, -167.19 APE8-dihe-in -52.73, 117.36 APE8-rot-in 317.57 APE67-dihe-in -83.41, -9.75 -51.91, -36.4 APE12-dist-in 11.747 APE11-dist-out 7.298 APE10-dist-out 10.88 APE9-dist-in 4.486 None None None XRAY 2.5 0.229 0.253 B 271 252 18 0 0 8 [[678, 938]] 1.0 5uox Homo sapiens STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5UP3A Q99683 670 940 1374.0 8GS:1000 Type1 Inactive DFGin 6.503 13.746 BLAminus -134.17, 163.34 57.48, 95.37 -105.83, 15.56 294.57, 82.67 -54.1, -37.9 in-in in 8.252 Saltbr-in 2.749 HRD-in -77.73, -45.36 66.12, 18.38 in-in-out SNCiio in-out ActLoopNT-in 3.138 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -130.48, 142.85 APE9-dihe-na -72.74, -170.17 APE8-dihe-in -68.28, 136.12 APE8-rot-in 330.15 APE67-dihe-in -69.45, -7.96 -67.67, -44.97 APE12-dist-in 10.899 APE11-dist-out 5.945 APE10-dist-out 10.093 APE9-dist-in 4.099 None None None XRAY 2.95 0.244 0.289 A 271 258 13 0 0 8 [[678, 938]] 1.0 5up3 Homo sapiens STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5V19A Q99683 671 939 1374.0 8V4:1000 Type1 Inactive DFGin 6.771 13.638 BLAminus -132.57, 160.59 69.04, 95.45 -107.1, 23.8 302.48, 89.72 -68.71, -20.94 in-in in 8.863 Saltbr-in 2.938 HRD-in -85.68, -36.78 73.98, -9.49 in-in-out SNCiio in-out ActLoopNT-in 3.324 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.73, 133.17 APE9-dihe-na -80.05, -161.91 APE8-dihe-in -68.3, 136.17 APE8-rot-in 312.97 APE67-dihe-in -77.38, -19.64 -51.76, -48.3 APE12-dist-in 10.94 APE11-dist-out 5.65 APE10-dist-out 9.935 APE9-dist-in 4.11 None None None XRAY 3.1 0.24 0.285 A 271 250 19 0 0 8 [[678, 938]] 1.0 5v19 Homo sapiens STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5V19B Q99683 670 940 1374.0 8V4:1000 Type1 Inactive DFGin 6.938 13.448 BLAminus -112.09, 157.87 57.47, 105.0 -111.04, 30.03 305.07, 81.48 -71.73, -31.06 in-in in 8.592 Saltbr-in 2.557 HRD-in -80.87, -49.12 78.13, 3.37 in-in-out SNCiio in-out ActLoopNT-in 3.042 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -137.42, 143.7 APE9-dihe-na -80.99, -172.63 APE8-dihe-in -58.34, 134.74 APE8-rot-in 315.96 APE67-dihe-in -73.15, -18.54 -59.0, -41.5 APE12-dist-in 11.25 APE11-dist-out 5.956 APE10-dist-out 9.973 APE9-dist-in 4.033 None None None XRAY 3.1 0.24 0.285 B 271 260 11 0 0 6 [[678, 938]] 1.0 5v19 Homo sapiens STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5V24A Q99683 671 939 1374.0 8V7:1000 Type1 Inactive DFGin 6.444 13.822 BLAminus -138.79, 167.29 63.07, 92.92 -98.6, 22.14 301.17, 102.16 -63.35, -34.76 in-in in 8.552 Saltbr-in 2.654 HRD-in -79.39, -51.03 79.68, 9.93 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -142.07, 141.87 APE9-dihe-na -76.32, -161.06 APE8-dihe-in -57.75, 128.66 APE8-rot-in 314.65 APE67-dihe-in -85.33, 2.43 -49.1, -51.24 APE12-dist-none 999.0 APE11-dist-out 7.359 APE10-dist-out 10.573 APE9-dist-in 4.031 None None None XRAY 2.5 0.236 0.266 A 271 249 20 0 0 9 [[678, 938]] 1.0 5v24 Homo sapiens STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5V24B Q99683 670 940 1374.0 8V7:1000 Type1 Inactive DFGin 6.686 13.947 BLAminus -131.97, 172.62 55.9, 93.07 -102.8, 24.69 298.12, 84.91 -61.85, -39.9 in-in in 8.482 Saltbr-in 2.679 HRD-in -70.58, -49.83 74.61, 10.19 in-in-out SNCiio in-out ActLoopNT-in 3.126 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -138.19, 141.87 APE9-dihe-na -76.77, -161.96 APE8-dihe-in -77.94, 133.6 APE8-rot-in 312.69 APE67-dihe-in -60.64, -16.25 -59.43, -53.7 APE12-dist-in 10.407 APE11-dist-out 5.924 APE10-dist-out 9.934 APE9-dist-in 3.922 None None None XRAY 2.5 0.236 0.266 B 271 263 8 0 0 8 [[678, 938]] 1.0 5v24 Homo sapiens STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 3VW6A Q99683 671 939 1374.0 IM6:1001 Type1 Inactive DFGin 6.766 13.694 BLAminus -134.4, 159.82 63.61, 96.18 -106.08, 19.14 299.77, 93.59 -65.67, -26.71 in-in in 8.348 Saltbr-in 2.744 HRD-in -68.63, -53.22 81.29, -1.87 in-in-out SNCiio in-out ActLoopNT-in 2.998 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -141.75, 135.33 APE9-dihe-na -74.82, -165.45 APE8-dihe-in -69.97, 129.12 APE8-rot-in 307.72 APE67-dihe-in -79.01, -8.94 -54.17, -44.62 APE12-dist-in 11.532 APE11-dist-out 5.609 APE10-dist-out 9.737 APE9-dist-in 3.76 None None None XRAY 2.4 0.215 0.252 A 269 255 14 0 0 8 [[678, 938]] 1.0 3vw6 Homo sapiens STE_MAP3K5_HUMAN STE 4.3e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 3VW6B Q99683 671 939 1374.0 IM6:1001 Type1 Inactive DFGin 6.473 13.757 BLAminus -134.33, 172.21 68.61, 93.15 -105.24, 21.46 296.68, 86.91 -65.52, -28.46 in-in in 8.526 Saltbr-in 2.628 HRD-in -73.34, -41.76 69.65, 0.5 in-in-out SNCiio in-out ActLoopNT-in 2.951 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 138.85 APE9-dihe-na -88.87, -154.31 APE8-dihe-in -65.66, 132.6 APE8-rot-in 313.09 APE67-dihe-in -73.68, -9.35 -60.99, -45.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.322 APE9-dist-in 4.141 None None None XRAY 2.4 0.215 0.252 B 269 253 16 0 0 10 [[678, 938]] 1.0 3vw6 Homo sapiens STE_MAP3K5_HUMAN STE 4.3e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5UORA Q99683 671 939 1374.0 8GV:1002 Type1 Inactive DFGin 6.285 13.634 BLAminus -134.65, 172.67 64.32, 97.84 -109.08, 20.19 301.0, 92.78 -63.64, -23.3 in-in in 8.61 Saltbr-in 2.949 HRD-in -71.8, -45.36 73.85, 8.78 in-in-out SNCiio in-out ActLoopNT-in 2.826 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -118.5, 140.85 APE9-dihe-na -76.55, -167.59 APE8-dihe-in -50.1, 126.77 APE8-rot-in 307.11 APE67-dihe-in -83.03, -7.05 -61.2, -41.39 APE12-dist-none 999.0 APE11-dist-out 7.181 APE10-dist-out 10.383 APE9-dist-in 4.126 None None None XRAY 2.75 0.205 0.267 A 270 249 20 0 0 9 [[678, 938]] 1.0 5uor Homo sapiens STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5UORB Q99683 670 939 1374.0 8GV:1002 Type1 Inactive DFGin 6.75 13.91 BLAminus -134.49, 175.22 58.2, 82.47 -94.06, 20.8 300.48, 89.65 -68.28, -20.03 in-in in 8.28 Saltbr-in 2.724 HRD-in -77.75, -45.92 73.94, 0.98 in-in-out SNCiio in-out ActLoopNT-in 3.374 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -135.92, 146.73 APE9-dihe-na -84.86, -151.59 APE8-dihe-in -81.41, 127.68 APE8-rot-in 321.22 APE67-dihe-in -73.68, -9.98 -53.85, -46.25 APE12-dist-in 10.191 APE11-dist-out 6.107 APE10-dist-out 10.046 APE9-dist-in 3.92 None None None XRAY 2.75 0.205 0.267 B 270 262 8 0 0 8 [[678, 938]] 1.0 5uor Homo sapiens STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5VILA Q99683 670 940 1374.0 9E1:1001 Type1 Inactive DFGin 6.933 13.736 BLAminus -129.43, 176.25 60.35, 85.87 -93.88, 20.78 296.68, 103.23 -63.59, -38.71 in-in in 8.355 Saltbr-in 2.688 HRD-in -75.14, -44.27 72.6, -5.11 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -143.33, 133.88 APE9-dihe-na -70.29, -167.94 APE8-dihe-in -59.8, 126.12 APE8-rot-in 306.7 APE67-dihe-in -62.88, -21.68 -55.02, -48.15 APE12-dist-in 10.92 APE11-dist-out 5.948 APE10-dist-out 10.119 APE9-dist-in 3.815 None None None XRAY 2.64 0.182 0.213 A 293 271 0 0 0 0 [[678, 938]] 1.0 5vil Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5VILB Q99683 670 940 1374.0 9E1:1001 Type1 Inactive DFGin 6.913 13.674 BLAminus -121.19, 167.94 68.48, 86.11 -93.27, 20.53 296.7, 102.83 -62.35, -37.98 in-in in 8.318 Saltbr-in 2.667 HRD-in -70.92, -45.87 72.04, -5.16 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -141.25, 132.0 APE9-dihe-na -63.72, -152.68 APE8-dihe-in -74.74, 128.19 APE8-rot-in 305.46 APE67-dihe-in -63.18, -22.1 -55.97, -47.17 APE12-dist-in 11.048 APE11-dist-out 5.867 APE10-dist-out 9.963 APE9-dist-in 3.792 None None None XRAY 2.64 0.182 0.213 B 293 271 0 0 0 0 [[678, 938]] 1.0 5vil Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5VILD Q99683 670 940 1374.0 9E1:4000 Type1 Inactive DFGin 6.779 13.613 BLAminus -128.96, 165.86 71.52, 86.1 -95.58, 18.32 298.51, 100.04 -52.66, -47.62 in-in in 7.954 Saltbr-in 2.809 HRD-in -73.79, -44.06 70.88, -5.49 in-in-out SNCiio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -141.86, 132.52 APE9-dihe-na -65.19, -151.72 APE8-dihe-in -74.93, 128.69 APE8-rot-in 307.23 APE67-dihe-in -63.61, -21.82 -53.86, -49.12 APE12-dist-in 10.493 APE11-dist-out 5.673 APE10-dist-out 10.159 APE9-dist-in 3.849 None None None XRAY 2.64 0.182 0.213 D 293 271 0 0 0 0 [[678, 938]] 1.0 5vil Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5VIOA Q99683 670 940 1374.0 9E4:4000 Type1 Inactive DFGin 6.963 13.857 BLAminus -120.46, 173.33 58.3, 94.09 -102.99, 24.25 296.09, 98.08 -66.08, -35.82 in-in in 8.414 Saltbr-in 2.745 HRD-in -74.97, -41.99 72.76, -8.55 in-in-out SNCiio in-out ActLoopNT-in 2.824 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -143.49, 136.16 APE9-dihe-na -74.12, -165.55 APE8-dihe-in -61.09, 127.54 APE8-rot-in 313.48 APE67-dihe-in -63.75, -24.16 -54.98, -45.49 APE12-dist-in 10.763 APE11-dist-out 5.915 APE10-dist-out 9.968 APE9-dist-in 3.914 None None None XRAY 2.84 0.181 0.216 A 293 271 0 0 0 0 [[678, 938]] 1.0 5vio Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5VIOB Q99683 670 940 1374.0 9E4:4000 Type1 Inactive DFGin 6.797 13.686 BLAminus -122.07, 170.59 66.33, 91.8 -101.04, 21.2 296.32, 98.87 -63.35, -42.36 in-in in 8.307 Saltbr-in 2.736 HRD-in -72.93, -48.35 79.14, -10.27 in-in-out SNCiio in-out ActLoopNT-in 2.786 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -138.69, 137.19 APE9-dihe-na -68.58, -161.75 APE8-dihe-in -67.24, 126.86 APE8-rot-in 310.59 APE67-dihe-in -63.64, -24.3 -54.0, -45.67 APE12-dist-in 10.997 APE11-dist-out 5.739 APE10-dist-out 9.813 APE9-dist-in 3.922 None None None XRAY 2.84 0.181 0.216 B 293 271 0 0 0 0 [[678, 938]] 1.0 5vio Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5VIOD Q99683 670 940 1374.0 9E4:4000 Type1 Inactive DFGin 6.729 13.751 BLAminus -125.66, 172.5 64.37, 91.94 -102.27, 19.02 296.92, 97.46 -79.31, 7.01 in-in in 8.464 Saltbr-in 2.794 HRD-in -62.69, -41.35 70.75, -12.73 in-in-out SNCiio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -145.74, 135.42 APE9-dihe-na -73.58, -160.05 APE8-dihe-in -65.52, 127.14 APE8-rot-in 313.58 APE67-dihe-in -64.57, -23.44 -53.04, -46.36 APE12-dist-in 11.116 APE11-dist-out 5.838 APE10-dist-out 9.692 APE9-dist-in 4.01 None None None XRAY 2.84 0.181 0.216 D 293 271 0 0 0 0 [[678, 938]] 1.0 5vio Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6XIHA Q99683 671 940 1374.0 V3S:1000 Type1 Inactive DFGin 6.699 13.935 BLAminus -124.24, 171.43 62.39, 90.11 -100.17, 18.2 296.55, 92.58 -52.23, -40.83 in-in in 8.395 Saltbr-in 2.71 HRD-in -75.25, -49.42 79.66, 5.85 in-in-out SNCiio in-out ActLoopNT-in 3.176 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -129.36, 154.65 APE9-dihe-na -92.62, -162.28 APE8-dihe-in -70.59, 130.07 APE8-rot-in 331.74 APE67-dihe-in -62.68, -15.95 -64.17, -51.46 APE12-dist-in 10.956 APE11-dist-out 5.963 APE10-dist-out 10.005 APE9-dist-in 3.931 None None None XRAY 2.65 0.228 0.292 A 295 258 12 0 0 8 [[678, 938]] 1.0 6xih Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6XIHB Q99683 671 939 1374.0 V3S:1000 Type1 Inactive DFGin 6.609 13.675 BLAminus -132.91, 163.64 66.06, 96.79 -103.4, 13.78 297.24, 111.79 -55.47, -33.38 in-in in 8.67 Saltbr-in 2.666 HRD-in -84.49, -53.59 86.87, -13.44 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 156.58 APE8-dihe-in -52.99, 137.0 APE8-rot-out 62.22 APE67-dihe-in -90.67, 5.14 -61.89, -43.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.132 None None None XRAY 2.65 0.228 0.292 B 295 246 23 0 0 12 [[678, 938]] 1.0 6xih Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6E2MB Q99683 671 940 1374.0 KK7:1001 Type1 Inactive DFGin 6.519 13.69 BLAminus -124.37, 175.44 61.51, 85.57 -96.57, 16.8 298.76, 85.53 -59.98, -32.28 in-in in 8.194 Saltbr-in 2.519 HRD-in -74.6, -57.55 88.85, -0.31 in-in-out SNCiio in-out ActLoopNT-in 3.048 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 92.46 APE9-dihe-na -97.99, -118.26 APE8-dihe-in -118.56, 131.17 APE8-rot-in 295.79 APE67-dihe-in -69.37, -11.46 -56.54, -49.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.386 APE9-dist-in 3.765 None TPO838 TPO838 XRAY 2.253 0.218 0.259 B 295 248 22 0 0 10 [[678, 938]] 1.0 6e2m Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6E2OB Q99683 671 939 1374.0 S0L:1001 Type1 Inactive DFGin 6.455 14.013 BLAminus -123.87, 176.77 53.57, 98.76 -104.53, 24.03 295.0, 85.92 -63.99, -37.99 in-in in 8.498 Saltbr-in 2.237 HRD-in -70.67, -52.1 75.95, 3.25 in-in-out SNCiio in-out ActLoopNT-in 3.062 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 132.02 APE9-dihe-na -86.03, -126.81 APE8-dihe-in -106.63, 130.74 APE8-rot-in 293.08 APE67-dihe-in -80.88, 1.52 -56.21, -44.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.61 APE9-dist-in 3.585 None TPO838 TPO838 XRAY 2.389 0.217 0.268 B 295 250 19 0 0 10 [[678, 938]] 1.0 6e2o Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6VREA Q99683 671 940 1374.0 RFG:1002 Type1 Inactive DFGin 6.815 13.611 BLAminus -129.9, 174.85 60.66, 96.18 -107.07, 14.48 299.67, 100.35 -66.93, -27.63 in-in in 8.337 Saltbr-in 2.698 HRD-in -75.62, -47.02 73.48, 5.8 in-in-out SNCiio in-out ActLoopNT-in 3.082 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.85, 140.4 APE9-dihe-na -80.98, -165.5 APE8-dihe-in -71.42, 135.62 APE8-rot-in 312.64 APE67-dihe-in -74.41, -14.28 -63.87, -41.58 APE12-dist-in 10.791 APE11-dist-out 5.429 APE10-dist-out 9.876 APE9-dist-in 3.7 None None None XRAY 2.29 0.19 0.24 A 291 261 9 0 0 7 [[678, 938]] 1.0 6vre Homo sapiens STE_MAP3K5_HUMAN STE 1.2e-80 276.7 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6VREB Q99683 669 940 1374.0 RFG:1001 Type1 Inactive DFGin 6.49 14.012 BLAminus -129.48, 175.2 61.52, 95.42 -105.05, 19.46 294.04, 89.61 -65.54, -30.46 in-in in 8.749 Saltbr-in 2.576 HRD-in -76.83, -46.56 70.39, 7.92 in-in-out SNCiio in-out ActLoopNT-in 3.122 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 135.01 APE9-dihe-na -90.36, -169.74 APE8-dihe-in -80.73, 139.41 APE8-rot-out 88.48 APE67-dihe-in -72.31, -15.25 -63.35, -40.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.556 APE9-dist-in 3.709 None None None XRAY 2.29 0.19 0.24 B 291 260 12 0 0 8 [[678, 938]] 1.0 6vre Homo sapiens STE_MAP3K5_HUMAN STE 1.2e-80 276.7 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6OYWB Q99683 671 940 1374.0 NKJ:1001 Type1 Inactive DFGin 6.69 13.868 BLAminus -122.51, 166.6 60.27, 92.71 -105.19, 18.97 297.73, 95.21 -67.14, -20.88 in-in in 8.573 Saltbr-in 2.696 HRD-in -76.18, -44.1 70.51, 11.85 in-in-out SNCiio in-out ActLoopNT-in 3.186 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 104.69 APE9-dihe-na -71.78, -150.4 APE8-dihe-in -87.95, 134.15 APE8-rot-in 310.76 APE67-dihe-in -70.38, -10.89 -59.89, -50.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.132 APE9-dist-in 3.937 T838E None None XRAY 2.603 0.21 0.255 B 294 256 14 0 0 10 [[678, 938]] 1.0 6oyw Homo sapiens STE_MAP3K5_HUMAN STE 1.2e-80 276.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6OYWC Q99683 671 939 1374.0 NKJ:1001 Type1 Inactive DFGin 6.822 14.194 BLAminus -125.99, 170.88 63.72, 91.25 -105.44, 18.69 294.07, 95.01 -66.78, -18.88 in-in in 8.829 Saltbr-in 2.614 HRD-in -80.6, -45.91 69.98, 10.62 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -133.5, 148.17 APE9-dihe-na -70.3, -155.77 APE8-dihe-in -88.98, 138.74 APE8-rot-out 85.39 APE67-dihe-in -67.74, -14.04 -56.79, -47.02 APE12-dist-in 10.985 APE11-dist-out 6.032 APE10-dist-out 10.236 APE9-dist-in 3.675 T838E None None XRAY 2.603 0.21 0.255 C 294 260 9 0 0 5 [[678, 938]] 1.0 6oyw Homo sapiens STE_MAP3K5_HUMAN STE 1.2e-80 276.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BIBA Q99683 670 939 1374.0 IEO:1940 Type1 Inactive DFGin 6.89 13.685 BLAminus -101.96, 171.68 56.63, 96.52 -108.09, 9.31 305.46, 105.24 -97.03, 34.5 out-out out 10.328 Saltbr-out 7.92 HRD-in -62.68, -55.31 79.51, -12.34 out-in-out SNCoio in-out ActLoopNT-in 3.05 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.73, 130.88 APE9-dihe-na -70.59, -168.47 APE8-dihe-in -67.53, 132.39 APE8-rot-in 314.8 APE67-dihe-in -64.88, -13.63 -56.67, -50.04 APE12-dist-in 10.466 APE11-dist-out 5.099 APE10-dist-out 9.673 APE9-dist-in 3.448 T838E None None XRAY 2.43 0.203 0.239 A 318 254 16 0 0 8 [[678, 938]] 1.0 4bib Homo sapiens STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BIBB Q99683 670 940 1374.0 IEO:1941 Type1 Inactive DFGin 6.831 14.076 BLAminus -122.95, 179.25 61.68, 85.04 -100.41, 15.31 300.43, 103.7 -75.4, -20.2 in-out in 9.316 Saltbr-out 3.868 HRD-in -65.57, -43.92 69.2, -4.11 out-in-out SNCoio in-out ActLoopNT-in 2.937 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -130.37, 121.6 APE9-dihe-na -77.09, -118.37 APE8-dihe-in -118.52, 124.53 APE8-rot-in 308.41 APE67-dihe-in -63.49, -22.1 -41.53, -59.58 APE12-dist-none 999.0 APE11-dist-out 6.717 APE10-dist-out 9.995 APE9-dist-in 3.718 T838E None None XRAY 2.43 0.203 0.239 B 318 258 13 0 0 9 [[678, 938]] 1.0 4bib Homo sapiens STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BICA Q99683 670 940 1374.0 IE4:1 Type1 Inactive DFGin 7.014 13.672 BLAminus -101.38, -174.95 48.39, 111.02 -118.16, 17.14 290.62, 103.28 -72.3, -34.21 out-out out 10.422 Saltbr-out 7.556 HRD-in -64.29, -55.3 81.29, -4.92 out-in-out SNCoio in-out ActLoopNT-in 3.178 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.95, 136.62 APE9-dihe-na -70.67, -159.58 APE8-dihe-in -81.37, 127.16 APE8-rot-in 311.94 APE67-dihe-in -65.51, -3.48 -48.39, -54.68 APE12-dist-in 11.181 APE11-dist-out 5.628 APE10-dist-out 9.712 APE9-dist-in 3.469 T838E None None XRAY 2.62 0.209 0.265 A 318 260 11 0 0 6 [[678, 938]] 1.0 4bic Homo sapiens STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BIDA Q99683 670 939 1374.0 IE8:4000 Type1 Inactive DFGin 7.683 14.817 BLAminus -102.49, -169.5 32.62, 94.58 -110.23, 27.35 288.25, 85.03 -82.81, -25.67 in-out in 9.896 Saltbr-out 8.838 HRD-in -80.59, -44.06 71.64, -12.71 out-in-out SNCoio in-out ActLoopNT-in 3.212 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.03, 154.58 APE9-dihe-na -83.3, -134.14 APE8-dihe-in -115.1, 122.45 APE8-rot-in 304.44 APE67-dihe-in -76.51, -1.93 -39.2, -49.34 APE12-dist-in 10.168 APE11-dist-out 5.585 APE10-dist-out 9.425 APE9-dist-in 3.522 T838E None None XRAY 2.8 0.196 0.259 A 318 254 16 0 0 8 [[678, 938]] 1.0 4bid Homo sapiens STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BIDB Q99683 670 940 1374.0 IE8:4000 Type1 Inactive DFGin 7.305 14.814 BLAminus -128.81, -175.28 60.09, 79.34 -98.8, 16.39 285.54, 85.11 -71.67, -26.71 in-in in 8.688 Saltbr-in 3.005 HRD-in -85.3, -31.09 65.9, -13.52 in-in-out SNCiio in-out ActLoopNT-in 3.219 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -142.53, 121.12 APE9-dihe-na -74.7, -130.34 APE8-dihe-in -116.64, 122.41 APE8-rot-in 302.24 APE67-dihe-in -59.91, -43.52 -38.81, -52.5 APE12-dist-none 999.0 APE11-dist-out 7.301 APE10-dist-out 9.761 APE9-dist-in 3.542 T838E None None XRAY 2.8 0.196 0.259 B 318 258 13 0 0 9 [[678, 938]] 1.0 4bid Homo sapiens STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BIEA Q99683 670 940 1374.0 IE6:1942 Type1 Inactive DFGin 6.625 13.335 BLAminus -106.98, -175.45 45.85, 99.41 -108.71, 17.72 301.37, 101.11 -72.7, -39.67 in-in in 8.47 Saltbr-in 2.948 HRD-in -68.25, -48.97 78.37, -0.9 in-in-out SNCiio in-out ActLoopNT-in 3.202 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.69, 130.25 APE9-dihe-na -69.58, -174.96 APE8-dihe-in -63.32, 129.38 APE8-rot-in 309.24 APE67-dihe-in -64.21, -7.52 -51.07, -54.4 APE12-dist-in 10.792 APE11-dist-out 5.249 APE10-dist-out 9.422 APE9-dist-in 3.381 T838E None None XRAY 2.36 0.212 0.253 A 318 257 14 0 0 6 [[678, 938]] 1.0 4bie Homo sapiens STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BIEB Q99683 670 941 1374.0 IE6:1943 Type1 Inactive DFGin 6.549 13.473 BLAminus -114.43, 179.36 48.03, 98.73 -110.34, 26.8 303.44, 92.42 -71.11, -34.15 in-in in 8.588 Saltbr-in 3.013 HRD-in -66.09, -44.17 66.71, 1.27 in-in-out SNCiio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.98, 115.45 APE9-dihe-na -86.27, -157.16 APE8-dihe-in -81.66, 117.27 APE8-rot-in 313.7 APE67-dihe-in -62.93, -22.85 -39.01, -55.55 APE12-dist-none 999.0 APE11-dist-out 6.99 APE10-dist-out 9.921 APE9-dist-in 4.088 T838E None None XRAY 2.36 0.212 0.253 B 318 257 15 0 0 8 [[678, 938]] 1.0 4bie Homo sapiens STE_MAP3K5_HUMAN STE 1.6e-80 276.2 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BF2A Q99683 671 939 1374.0 STU:1940 Type1 Inactive DFGin 7.213 13.807 BLAminus -114.3, -178.78 51.44, 86.67 -90.54, 15.85 294.66, 96.8 -75.78, -2.2 out-none out 10.049 Saltbr-none 999.0 HRD-in -67.79, -49.78 78.33, -4.9 none-in-out SNCnio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -128.2, 134.23 APE9-dihe-na -68.74, -169.24 APE8-dihe-in -70.38, 133.03 APE8-rot-in 304.95 APE67-dihe-in -66.2, -12.84 -50.6, -52.99 APE12-dist-in 11.059 APE11-dist-out 5.44 APE10-dist-out 9.736 APE9-dist-in 3.512 T838E None None XRAY 2.11 0.208 0.247 A 334 253 16 0 0 6 [[678, 938]] 1.0 4bf2 Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BF2B Q99683 671 940 1374.0 STU:1941 Type1 Inactive DFGin 6.92 13.803 BLAminus -128.63, -177.63 56.0, 77.77 -86.85, 11.45 292.4, 104.75 -69.02, -19.49 in-none in 9.74 Saltbr-none 999.0 HRD-in -67.52, -45.29 72.76, -9.25 none-in-out SNCnio in-out ActLoopNT-in 3.012 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 145.57 APE9-dihe-na -77.44, -148.98 APE8-dihe-in -83.86, 130.43 APE8-rot-in 307.99 APE67-dihe-in -59.87, -30.7 -43.72, -58.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.696 APE9-dist-in 3.527 T838E None None XRAY 2.11 0.208 0.247 B 334 252 18 0 0 9 [[678, 938]] 1.0 4bf2 Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BHNA Q99683 670 940 1374.0 BH9:1 Type1 Inactive DFGin 6.641 13.419 BLAminus -116.15, 170.7 61.91, 107.63 -114.13, 14.36 294.82, 100.14 -70.55, -20.89 in-in in 8.61 Saltbr-in 2.802 HRD-in -66.8, -54.62 82.11, -4.15 in-in-out SNCiio in-out ActLoopNT-in 3.244 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.48, 131.86 APE9-dihe-na -68.23, -173.64 APE8-dihe-in -65.87, 129.94 APE8-rot-in 307.79 APE67-dihe-in -62.92, -9.87 -53.4, -53.13 APE12-dist-in 10.033 APE11-dist-out 5.14 APE10-dist-out 9.619 APE9-dist-in 3.441 T838E None None XRAY 2.3 0.197 0.235 A 334 256 15 0 0 8 [[678, 938]] 1.0 4bhn Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 4BHNB Q99683 670 938 1374.0 BH9:1 Type1 Inactive DFGin 6.663 13.551 BLAminus -127.02, 174.96 58.51, 91.28 -97.83, 21.74 301.12, 94.31 -63.02, -40.41 in-in in 8.459 Saltbr-in 2.595 HRD-in -66.57, -49.23 72.07, 1.38 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -134.18, 113.64 APE9-dihe-na -75.96, -135.55 APE8-dihe-in -93.54, 117.0 APE8-rot-in 314.59 APE67-dihe-in -59.83, -23.07 -45.36, -57.56 APE12-dist-none 999.0 APE11-dist-out 6.948 APE10-dist-out 10.229 APE9-dist-in 4.249 T838E None None XRAY 2.3 0.197 0.235 B 334 257 12 0 0 8 [[678, 938]] 1.0 4bhn Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 7MU6A Q99683 671 939 1374.0 A1AWT:1001 Type1 Inactive DFGin 6.806 13.81 BLAminus -134.71, 172.36 55.8, 97.35 -103.45, 21.85 298.86, 96.76 -71.3, -26.18 in-in in 8.335 Saltbr-in 2.513 HRD-in -80.43, -45.88 78.17, 0.0 in-in-out SNCiio in-out ActLoopNT-in 3.129 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -110.25, 144.39 APE9-dihe-na -81.83, -163.92 APE8-dihe-in -76.49, 135.89 APE8-rot-in 306.21 APE67-dihe-in -72.49, -10.64 -62.48, -45.91 APE12-dist-in 10.534 APE11-dist-out 5.142 APE10-dist-out 9.751 APE9-dist-in 3.698 None None None XRAY 2.165 0.191 0.214 A 334 259 10 0 0 7 [[678, 938]] 1.0 7mu6 Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 7MU7A Q99683 671 940 1374.0 RFG:1003 Type1 Inactive DFGin 6.757 13.715 BLAminus -136.15, -179.86 56.07, 94.54 -107.99, 16.99 301.26, 96.73 -67.77, -29.01 in-in in 8.381 Saltbr-in 2.688 HRD-in -75.3, -47.48 74.9, 5.08 in-in-out SNCiio in-out ActLoopNT-in 3.099 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -120.97, 138.28 APE9-dihe-na -81.33, -164.64 APE8-dihe-in -73.3, 130.4 APE8-rot-in 314.02 APE67-dihe-in -72.58, -18.66 -57.86, -41.71 APE12-dist-in 10.763 APE11-dist-out 5.421 APE10-dist-out 9.886 APE9-dist-in 3.66 None None None XRAY 2.298 0.207 0.242 A 334 263 7 0 0 7 [[678, 938]] 1.0 7mu7 Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 7MU7B Q99683 669 940 1374.0 RFG:1003 Type1 Inactive DFGin 6.456 14.084 BLAminus -133.69, 179.33 55.17, 97.63 -107.16, 19.31 292.8, 94.2 -66.83, -32.31 in-in in 8.714 Saltbr-in 2.699 HRD-in -75.96, -46.83 74.41, 6.4 in-in-out SNCiio in-out ActLoopNT-in 3.098 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 134.07 APE9-dihe-na -87.4, -167.12 APE8-dihe-in -77.87, 130.78 APE8-rot-in 312.34 APE67-dihe-in -72.25, -17.64 -58.41, -40.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.498 APE9-dist-in 3.558 None None None XRAY 2.298 0.207 0.242 B 334 260 12 0 0 8 [[678, 938]] 1.0 7mu7 Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5VIOC Q99683 670 940 1374.0 No_ligand No_ligand Inactive DFGin 6.357 13.825 None -118.22, -166.23 70.4, -83.21 71.44, -145.78 303.48, 97.0 79.63, -42.0 in-in in 8.384 Saltbr-in 2.948 HRD-in -67.24, -40.33 70.79, -6.68 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -146.22, 135.17 APE9-dihe-na -72.34, -160.36 APE8-dihe-in -65.61, 126.24 APE8-rot-in 312.24 APE67-dihe-in -64.54, -23.72 -53.71, -45.87 APE12-dist-in 10.919 APE11-dist-out 5.816 APE10-dist-out 9.827 APE9-dist-in 3.919 None None None XRAY 2.84 0.181 0.216 C 293 271 0 0 0 0 [[678, 938]] 1.0 5vio Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5VILC Q99683 670 940 1374.0 9E1:4000 Type1 Inactive DFGin 6.681 13.665 None -127.14, -166.22 81.0, -82.49 64.22, -158.94 310.26, 99.86 83.75, -48.04 in-in in 8.387 Saltbr-in 2.767 HRD-in -62.04, -44.3 71.5, -5.97 in-in-out SNCiio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -142.26, 132.14 APE9-dihe-na -63.89, -152.16 APE8-dihe-in -75.62, 128.61 APE8-rot-in 305.72 APE67-dihe-in -63.56, -22.05 -54.79, -48.45 APE12-dist-in 10.794 APE11-dist-out 5.814 APE10-dist-out 9.964 APE9-dist-in 3.826 None None None XRAY 2.64 0.182 0.213 C 293 271 0 0 0 0 [[678, 938]] 1.0 5vil Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 2CLQA Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 5.918 8.469 BABtrans -91.39, 129.8 -141.56, 7.65 -79.81, 110.16 226.87, 94.37 134.88, -46.11 out-out out 10.127 Saltbr-out 4.796 HRD-in -81.27, -49.85 78.55, 0.8 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -136.64, 134.41 APE9-dihe-na -79.2, -159.26 APE8-dihe-in -79.76, 137.19 APE8-rot-in 323.06 APE67-dihe-in -73.67, -16.9 -62.96, -40.27 APE12-dist-in 11.61 APE11-dist-out 6.223 APE10-dist-out 10.04 APE9-dist-in 3.702 None None None XRAY 2.3 0.204 0.257 A 295 263 8 0 0 5 [[678, 938]] 1.0 2clq Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 2CLQB Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 6.564 8.021 BABtrans -97.55, 126.7 -140.68, 10.18 -79.54, 109.54 215.05, 109.45 130.73, -46.4 in-none in 9.98 Saltbr-none 999.0 HRD-in -83.48, -49.36 79.39, -1.77 none-in-out SNCnio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.24, 136.94 APE9-dihe-na -82.54, -165.1 APE8-dihe-in -71.26, 138.19 APE8-rot-in 313.5 APE67-dihe-in -70.89, -23.23 -61.89, -43.74 APE12-dist-none 999.0 APE11-dist-out 6.267 APE10-dist-out 10.013 APE9-dist-in 3.749 None None None XRAY 2.3 0.204 0.257 B 295 259 12 0 0 8 [[678, 938]] 1.0 2clq Homo sapiens STE_MAP3K5_HUMAN STE 5.9e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 8QGYA Q99683 95 940 1374.0 No_ligand No_ligand Inactive DFGout 12.319 7.832 None -113.17, 136.85 -125.29, 138.85 -124.85, 84.07 305.69, 87.83 61.56, 19.79 in-out in 7.925 Saltbr-out 6.419 HRD-out -77.96, 140.03 -109.85, 144.64 out-in-none SNCoin in-none ActLoopNT-in 2.987 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -38.63 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.71 999.0 999.0 A 896 780 33 0 0 13 [[678, 938]] 1.0 8qgy Homo sapiens STE_MAP3K5_HUMAN STE 1.1e-79 273.9 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6OYTA Q99683 667 939 1374.0 NJV:61001 Type1 None DFGin 5.681 13.351 BLAminus -125.18, 173.88 59.78, 86.22 -94.31, 25.78 300.06, 101.7 -62.97, -32.35 in-in in 8.832 Saltbr-in 2.26 HRD-in -73.98, -49.46 76.75, 0.8 in-in-none SNCiin in-none ActLoopNT-in 2.979 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.824 0.235 0.29 A 280 221 52 0 0 20 [[678, 938]] 1.0 6oyt Homo sapiens STE_MAP3K5_HUMAN STE 5e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6OYTC Q99683 671 938 1374.0 NJV:61001 Type1 None DFGin 6.079 13.489 BLAminus -119.54, 172.14 56.5, 86.88 -93.47, 25.36 302.99, 99.79 -64.69, -32.12 in-in in 8.321 Saltbr-in 2.529 HRD-in -71.89, -48.46 74.08, 0.71 in-in-none SNCiin in-none ActLoopNT-in 3.275 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.69, -21.53 999.0, -119.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.824 0.235 0.29 C 280 236 32 0 0 13 [[678, 938]] 1.0 6oyt Homo sapiens STE_MAP3K5_HUMAN STE 5e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6OYTD Q99683 667 939 1374.0 NJV:61002 Type1 None DFGin 5.873 13.601 BLAminus -124.35, 174.62 60.77, 86.25 -96.47, 25.37 301.41, 82.49 -61.64, -30.64 in-in in 9.067 Saltbr-in 2.509 HRD-in -72.35, -49.7 75.51, 0.65 in-in-none SNCiin in-none ActLoopNT-in 2.818 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -134.49 APE8-dihe-in -107.42, 132.24 APE8-rot-in 319.21 APE67-dihe-in -73.68, -28.35 -46.85, -37.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.788 None None None XRAY 2.824 0.235 0.29 D 280 250 23 0 0 10 [[678, 938]] 1.0 6oyt Homo sapiens STE_MAP3K5_HUMAN STE 5e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 5UP3B Q99683 671 939 1374.0 8GS:1000 Type1 None DFGin 6.404 13.522 BLAminus -145.21, 155.75 74.64, 95.67 -108.04, 14.34 302.59, 105.08 -64.34, -17.97 in-in in 8.566 Saltbr-in 2.91 HRD-in -87.24, -40.99 75.36, -9.84 in-in-none SNCiin in-none ActLoopNT-in 3.023 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.91 APE8-dihe-in -57.21, 126.4 APE8-rot-in 314.64 APE67-dihe-in -121.68, -3.36 -59.97, -11.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.493 None None None XRAY 2.95 0.244 0.289 B 271 243 26 0 0 11 [[678, 938]] 1.0 5up3 Homo sapiens STE_MAP3K5_HUMAN STE 4.4e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 6E2NB Q99683 670 939 1374.0 KK8:1001 Type1 None DFGin 6.543 13.925 BLAminus -124.43, -172.06 45.44, 94.03 -100.49, 19.41 297.14, 84.65 -62.68, -39.36 in-in in 8.526 Saltbr-in 2.317 HRD-in -77.48, -52.13 80.81, -2.87 in-in-none SNCiin in-none ActLoopNT-in 3.176 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -34.96 APE9-dihe-na 147.14, -170.88 APE8-dihe-in -105.95, 128.57 APE8-rot-in 300.89 APE67-dihe-in -77.71, -0.68 -49.6, -53.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.857 APE9-dist-in 3.588 None TPO838 TPO838 XRAY 2.098 0.217 0.257 B 295 250 20 0 0 10 [[678, 938]] 1.0 6e2n Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
M3K5_HUMAN 7MU6B Q99683 671 940 1374.0 A1AWT:1001 Type1 None DFGin 6.472 13.842 BLAminus -137.24, 175.06 55.73, 97.84 -102.69, 23.8 295.93, 95.1 -68.36, -28.7 in-in in 8.476 Saltbr-in 2.441 HRD-in -80.7, -46.25 77.78, 2.33 in-in-none SNCiin in-none ActLoopNT-in 3.029 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 66.13 APE9-dihe-na -85.74, -166.57 APE8-dihe-in -87.23, 138.03 APE8-rot-in 306.07 APE67-dihe-in -71.64, -12.66 -62.6, -45.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.317 APE9-dist-in 3.356 None None None XRAY 2.165 0.191 0.214 B 334 261 9 0 0 9 [[678, 938]] 1.0 7mu6 Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5

STE_MAP3K5 (Mitogen-activated protein kinase kinase kinase 5)

Total number of chains: 0
Active chains: 0
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name