TYR_ITK (Tyrosine-protein kinase ITK/TSK)

Total number of chains: 59
Active chains: 2
Uniprot: ITK_HUMAN
Kinase Domain Residues: 363 - 614
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 25 42.4% 4RFMA
DFGin BLBplus 21 35.6% 9NWXA
DFGin None 10 16.9% 4PQNA
DFGin BLAminus 3 5.1% AF-Q08881-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q08881-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 355 - 620 0 None None Tyrosine-protein kinase ITK/TSK
AF-Q08881-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 355 - 620 0 None None Tyrosine-protein kinase ITK/TSK
3MIYB 1.67 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan B49 Type1 357 - 619 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK
4MF1A 2.113 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan 29Y Type1 357 - 619 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK
4MF1B 2.113 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nniai APEdist_aaao 29Y Type1 357 - 619 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK
4RFMA 2.1 Inactive DFGin‑BLAplus out-out out-out TYR APEdihe_nniai APEdist_aaao 3P6 Type1 357 - 618 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK
4KIOA 2.18 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan G5K Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
4KIOB 2.18 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan G5K Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
4KIOD 2.18 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan G6K Type1 357 - 618 0 None Y512E Tyrosine-protein kinase ITK/TSK
4L7SA 2.03 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan G7K Type1 357 - 620 0 None Y512E Tyrosine-protein kinase ITK/TSK
4L7SB 2.03 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan G7K Type1 357 - 620 0 None Y512E Tyrosine-protein kinase ITK/TSK
4MF0A 2.67 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 29Z Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
4PP9A 2.58 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan 2VT Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
4PP9B 2.58 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan 2VT Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
4QD6A 2.45 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 30T Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
3QGWA 2.1 Inactive DFGin‑BLAplus out-out none-out TYR APEdihe_nniai APEdist_aaao PQC Type1 358 - 618 0 None None Tyrosine-protein kinase ITK/TSK
3QGYA 2.1 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan PQC Type1 357 - 618 0 None None Tyrosine-protein kinase ITK/TSK
3V5JA 2.59 Inactive DFGin‑BLAplus out-none none-none TYR APEdihe_nnnai APEdist_aaan 0F2 Type1 357 - 618 0 None None Tyrosine-protein kinase ITK/TSK
3V5LA 1.86 Inactive DFGin‑BLAplus out-none none-none TYR APEdihe_nnnai APEdist_aaan 0G1 Type1 357 - 616 0 None None Tyrosine-protein kinase ITK/TSK
3V5LB 1.86 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 0G1 Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK
3V5LC 1.86 Inactive DFGin‑BLAplus in-out none-out TYR APEdihe_nnoai APEdist_aaao 0G1 Type1 357 - 616 0 None None Tyrosine-protein kinase ITK/TSK
3V5LD 1.86 Inactive DFGin‑BLAplus out-out none-out TYR APEdihe_nnoai APEdist_aaao 0G1 Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK
3V8TA 2.0 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 477 Type1 357 - 618 0 None None Tyrosine-protein kinase ITK/TSK
3V8TB 2.0 Inactive DFGin‑BLAplus out-none none-none TYR APEdihe_nnnai APEdist_aaan 477 Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK
3V8WA 2.27 Inactive DFGin‑BLAplus out-none none-none TYR APEdihe_nnnai APEdist_aaan 0G2 Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK
3V8WB 2.27 Inactive DFGin‑BLAplus out-none none-none TYR APEdihe_nnnai APEdist_aaan 0G2 Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK
4KIOC 2.18 Inactive DFGin‑BLAplus out-out none-out TYR APEdihe_nnoai APEdist_aaao G6K, G5K Type1, Type1 357 - 620 0 None Y512E Tyrosine-protein kinase ITK/TSK
1SNXA 3.2 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK
1SNXB 3.2 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK
3MJ2A 1.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao MJG Type1 357 - 615 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK
4PPAA 2.67 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VU Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
4PPAB 2.67 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VU Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
4PPBA 2.82 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VV Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
4PPBB 2.82 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VV Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
4QD6B 2.45 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 30T Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
1SM2A 2.3 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK
1SNUA 2.5 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK
4HCTA 1.48 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 18R Type1 354 - 618 0 None K596R Tyrosine-protein kinase ITK/TSK
4HCUA 1.43 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 13L Type1 356 - 618 0 None K596R Tyrosine-protein kinase ITK/TSK
4HCVA 1.48 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 13J Type1 356 - 618 0 None K596R Tyrosine-protein kinase ITK/TSK
9NWXA 1.348 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao A1B66 Type1 355 - 618 0 None None Tyrosine-protein kinase ITK/TSK
3T9TA 1.65 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao IAQ Type1 356 - 618 0 None F435T,K596R Tyrosine-protein kinase ITK/TSK
4M0YA 1.7 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao M0Y, M0Y Type1, Type3 356 - 618 0 None None Tyrosine-protein kinase ITK/TSK
4M14A 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao QWS, QWS Type1, Type3 355 - 617 0 None None Tyrosine-protein kinase ITK/TSK
4M12A 2.15 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 1YZ Type3 355 - 618 0 None None Tyrosine-protein kinase ITK/TSK
4M13A 1.85 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 1E0 Type3 355 - 618 0 None None Tyrosine-protein kinase ITK/TSK
4M15A 1.52 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao QWS, ADP Type3, ATPlike 355 - 617 0 None None Tyrosine-protein kinase ITK/TSK
4M0ZA 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao M0Z, M0Z Type3, Type1 355 - 618 0 None None Tyrosine-protein kinase ITK/TSK
3MIYA 1.67 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan B49 Type1 357 - 619 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK
3MJ1A 1.72 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 614 Type1 357 - 615 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK
4PQNA 1.71 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 2W6 Type1 357 - 615 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK
4MF0B 2.67 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 29Z Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
4PPCA 2.95 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VW Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
4PPCB 2.95 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VW Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK
3QGWB 2.1 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan L7A Type1 358 - 616 0 None None Tyrosine-protein kinase ITK/TSK
1SM2B 2.3 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK
1SNUB 2.5 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK
3V5JB 2.59 Inactive DFGin‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan 0F2 Type1 357 - 620 0 None None Tyrosine-protein kinase ITK/TSK
3QGYB 2.1 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan L7O Type1 357 - 616 0 None None Tyrosine-protein kinase ITK/TSK

TYR_ITK (Tyrosine-protein kinase ITK/TSK)

Total number of chains: 59
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 25 42.4% 4RFMA
DFGin BLBplus 21 35.6% 9NWXA
DFGin None 10 16.9% 4PQNA
DFGin BLAminus 3 5.1% AF-Q08881-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ITK_HUMAN AF-Q08881-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 355 - 620 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN AF-Q08881-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 355 - 620 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3MIYB 1.67 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan B49 Type1 357 - 619 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4MF1A 2.113 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan 29Y Type1 357 - 619 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4MF1B 2.113 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nniai APEdist_aaao 29Y Type1 357 - 619 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4RFMA 2.1 Inactive DFGin‑BLAplus out-out out-out TYR APEdihe_nniai APEdist_aaao 3P6 Type1 357 - 618 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4KIOA 2.18 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan G5K Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4KIOB 2.18 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan G5K Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4KIOD 2.18 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan G6K Type1 357 - 618 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4L7SA 2.03 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan G7K Type1 357 - 620 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4L7SB 2.03 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan G7K Type1 357 - 620 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4MF0A 2.67 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 29Z Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4PP9A 2.58 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan 2VT Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4PP9B 2.58 Inactive DFGin‑BLAplus in-out none-none TYR APEdihe_nnnai APEdist_aaan 2VT Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4QD6A 2.45 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 30T Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3QGWA 2.1 Inactive DFGin‑BLAplus out-out none-out TYR APEdihe_nniai APEdist_aaao PQC Type1 358 - 618 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3QGYA 2.1 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan PQC Type1 357 - 618 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3V5JA 2.59 Inactive DFGin‑BLAplus out-none none-none TYR APEdihe_nnnai APEdist_aaan 0F2 Type1 357 - 618 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3V5LA 1.86 Inactive DFGin‑BLAplus out-none none-none TYR APEdihe_nnnai APEdist_aaan 0G1 Type1 357 - 616 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3V5LB 1.86 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 0G1 Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3V5LC 1.86 Inactive DFGin‑BLAplus in-out none-out TYR APEdihe_nnoai APEdist_aaao 0G1 Type1 357 - 616 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3V5LD 1.86 Inactive DFGin‑BLAplus out-out none-out TYR APEdihe_nnoai APEdist_aaao 0G1 Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3V8TA 2.0 Inactive DFGin‑BLAplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 477 Type1 357 - 618 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3V8TB 2.0 Inactive DFGin‑BLAplus out-none none-none TYR APEdihe_nnnai APEdist_aaan 477 Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3V8WA 2.27 Inactive DFGin‑BLAplus out-none none-none TYR APEdihe_nnnai APEdist_aaan 0G2 Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3V8WB 2.27 Inactive DFGin‑BLAplus out-none none-none TYR APEdihe_nnnai APEdist_aaan 0G2 Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4KIOC 2.18 Inactive DFGin‑BLAplus out-out none-out TYR APEdihe_nnoai APEdist_aaao G6K, G5K Type1, Type1 357 - 620 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 1SNXA 3.2 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 1SNXB 3.2 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan No_ligand No_ligand 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3MJ2A 1.9 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao MJG Type1 357 - 615 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4PPAA 2.67 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VU Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4PPAB 2.67 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VU Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4PPBA 2.82 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VV Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4PPBB 2.82 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VV Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4QD6B 2.45 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 30T Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 1SM2A 2.3 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 1SNUA 2.5 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 357 - 619 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4HCTA 1.48 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 18R Type1 354 - 618 0 None K596R Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4HCUA 1.43 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 13L Type1 356 - 618 0 None K596R Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4HCVA 1.48 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 13J Type1 356 - 618 0 None K596R Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 9NWXA 1.348 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao A1B66 Type1 355 - 618 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3T9TA 1.65 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao IAQ Type1 356 - 618 0 None F435T,K596R Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4M0YA 1.7 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao M0Y, M0Y Type1, Type3 356 - 618 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4M14A 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao QWS, QWS Type1, Type3 355 - 617 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4M12A 2.15 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 1YZ Type3 355 - 618 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4M13A 1.85 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 1E0 Type3 355 - 618 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4M15A 1.52 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao QWS, ADP Type3, ATPlike 355 - 617 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4M0ZA 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao M0Z, M0Z Type3, Type1 355 - 618 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3MIYA 1.67 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan B49 Type1 357 - 619 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3MJ1A 1.72 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 614 Type1 357 - 615 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4PQNA 1.71 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 2W6 Type1 357 - 615 0 None C477S,E614A,E617A Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4MF0B 2.67 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 29Z Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4PPCA 2.95 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VW Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 4PPCB 2.95 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan 2VW Type1 357 - 619 0 None Y512E Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3QGWB 2.1 Inactive DFGin‑None in-out none-none TYR APEdihe_nnnai APEdist_aaan L7A Type1 358 - 616 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 1SM2B 2.3 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 1SNUB 2.5 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan STU Type1 358 - 617 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3V5JB 2.59 Inactive DFGin‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan 0F2 Type1 357 - 620 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens
ITK_HUMAN 3QGYB 2.1 None DFGin‑BLAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan L7O Type1 357 - 616 0 None None Tyrosine-protein kinase ITK/TSK Homo sapiens

TYR_ITK (Tyrosine-protein kinase ITK/TSK)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism