CMGC_CDK2 (Cyclin-dependent kinase 2)

Total number of chains: 660
Active chains: 214
Uniprot: CDK2_HUMAN
Kinase Domain Residues: 4 - 286
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 335 50.8% AF-P24941-K1A
DFGin BLBtrans 129 19.5% 1YKRA
DFGin BLBminus 92 13.9% 4GCJA
None None 64 9.7% 4KD1A
DFGin BLBplus 19 2.9% 2XNBA
DFGin None 17 2.6% 5UQ1C
DFGin ABAminus 3 0.5% 5NEVA
DFGout None 1 0.2% 5A14A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
4I3ZA 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.408 15.148 BLAminus -137.57, -176.06 52.96, 75.44 -91.33, 19.91 280.72, 70.75 -64.88, -19.38 in-in in 8.599 Saltbr-in 2.988 HRD-in -80.76, -55.87 72.55, 4.85 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.11, -96.25 APE9-dihe-na -51.92, 142.27 APE8-dihe-in -55.11, 135.08 APE8-rot-in 307.48 APE67-dihe-in -54.58, -26.51 -40.4, -56.95 APE12-dist-in 13.064 APE11-dist-in 10.585 APE10-dist-in 6.823 APE9-dist-in 3.305 None TPO160 TPO160 XRAY 2.05 0.199 0.228 A 296 296 0 0 0 0 [[4, 286]] 1.0 4i3z CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4I3ZC 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.367 15.146 BLAminus -139.14, -175.0 51.64, 79.19 -95.11, 18.85 278.6, 70.91 -64.63, -17.11 in-in in 8.653 Saltbr-in 2.979 HRD-in -79.85, -55.96 72.81, 4.84 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.52, -96.18 APE9-dihe-na -52.61, 142.23 APE8-dihe-in -53.61, 133.4 APE8-rot-in 308.84 APE67-dihe-in -53.33, -28.57 -37.02, -58.54 APE12-dist-in 13.081 APE11-dist-in 10.618 APE10-dist-in 6.861 APE9-dist-in 3.305 None TPO160 TPO160 XRAY 2.05 0.199 0.228 C 296 296 0 0 0 0 [[4, 286]] 1.0 4i3z CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QHRA 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.557 15.107 BLAminus -129.61, -176.27 55.27, 75.32 -97.07, 17.79 280.43, 72.68 -60.79, -23.59 in-in in 8.696 Saltbr-in 2.88 HRD-in -78.46, -57.59 71.9, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.99, 139.5 APE9-dihe-na 85.76, 129.74 APE8-dihe-in -56.31, 140.07 APE8-rot-in 302.24 APE67-dihe-in -65.07, -20.31 -41.24, -52.35 APE12-dist-in 12.989 APE11-dist-in 10.171 APE10-dist-in 7.111 APE9-dist-in 3.341 None TPO160 TPO160 XRAY 2.17 0.18 0.21 A 298 296 0 0 0 0 [[4, 286]] 1.0 3qhr CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QHRC 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.565 15.121 BLAminus -133.25, -174.75 53.96, 72.74 -93.36, 15.91 281.14, 71.23 -60.56, -21.49 in-in in 8.7 Saltbr-in 2.868 HRD-in -78.47, -57.15 72.13, 9.85 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 147.52 APE9-dihe-na 81.05, 137.24 APE8-dihe-in -64.2, 137.48 APE8-rot-in 304.68 APE67-dihe-in -62.37, -22.27 -38.55, -53.11 APE12-dist-in 12.985 APE11-dist-in 10.232 APE10-dist-in 6.99 APE9-dist-in 3.293 None TPO160 TPO160 XRAY 2.17 0.18 0.21 C 298 296 0 0 0 0 [[4, 286]] 1.0 3qhr CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QHWA 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.435 15.013 BLAminus -134.08, -174.07 54.44, 75.18 -91.31, 13.19 281.29, 72.4 -60.66, -23.16 in-in in 8.64 Saltbr-in 2.934 HRD-in -72.46, -52.11 70.84, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.61, -86.88 APE9-dihe-na -62.59, 147.47 APE8-dihe-in -61.56, 138.19 APE8-rot-in 297.56 APE67-dihe-in -60.69, -27.39 -44.54, -49.89 APE12-dist-in 12.995 APE11-dist-in 10.23 APE10-dist-in 6.782 APE9-dist-in 3.359 None TPO160 TPO160 XRAY 1.91 0.189 0.219 A 298 296 0 0 0 0 [[4, 286]] 1.0 3qhw CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QHWC 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.453 15.083 BLAminus -135.33, -175.53 57.5, 71.73 -89.85, 9.67 280.79, 72.12 -55.86, -26.79 in-in in 8.617 Saltbr-in 2.896 HRD-in -73.76, -53.15 71.96, 3.16 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.86, -80.28 APE9-dihe-na -65.52, 146.91 APE8-dihe-in -61.19, 139.69 APE8-rot-in 298.69 APE67-dihe-in -57.2, -28.53 -47.15, -50.79 APE12-dist-in 12.997 APE11-dist-in 10.133 APE10-dist-in 6.722 APE9-dist-in 3.361 None TPO160 TPO160 XRAY 1.91 0.189 0.219 C 298 296 0 0 0 0 [[4, 286]] 1.0 3qhw CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1JSTA 1 298 298.0 ATP:300 ATPlike Active DFGin 6.427 15.464 BLAminus -139.88, 179.46 48.93, 78.76 -92.24, 30.29 284.11, 71.63 -70.08, -30.4 in-in in 8.717 Saltbr-in 2.757 HRD-in -78.76, -47.67 60.69, 17.81 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.53, 164.64 APE9-dihe-na 80.72, 135.16 APE8-dihe-in -62.71, 138.95 APE8-rot-in 293.52 APE67-dihe-in -51.22, -30.94 -33.79, -62.16 APE12-dist-in 13.121 APE11-dist-in 11.934 APE10-dist-in 7.067 APE9-dist-in 3.277 None TPO160 TPO160 XRAY 2.6 0.2 999.0 A 298 298 0 0 0 0 [[4, 286]] 1.0 1jst CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1JSTC 1 298 298.0 ATP:300 ATPlike Active DFGin 6.225 15.133 BLAminus -133.76, 179.75 53.92, 86.29 -100.05, 15.63 279.16, 71.07 -59.91, -21.96 in-in in 8.679 Saltbr-in 2.947 HRD-in -76.84, -49.3 61.77, 13.04 in-in-in SNCiii in-in ActLoopNT-in 2.701 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.31, -163.7 APE9-dihe-na 66.67, 148.27 APE8-dihe-in -72.61, 126.34 APE8-rot-in 301.65 APE67-dihe-in -51.49, -27.24 -26.21, -64.21 APE12-dist-in 13.412 APE11-dist-in 12.741 APE10-dist-in 6.942 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.6 0.2 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 1jst CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2CJMA 1 292 298.0 ATP:1294 ATPlike Active DFGin 6.412 15.477 BLAminus -133.49, 174.28 59.08, 80.72 -93.05, 17.33 280.25, 71.88 -51.1, -37.87 in-in in 8.875 Saltbr-in 3.027 HRD-in -83.77, -55.33 74.52, 15.85 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, -48.89 APE9-dihe-na -98.03, 148.0 APE8-dihe-in -53.4, 136.55 APE8-rot-in 296.67 APE67-dihe-in -56.28, -31.52 -52.78, -45.83 APE12-dist-in 13.329 APE11-dist-in 10.553 APE10-dist-in 7.18 APE9-dist-in 3.464 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 A 298 287 5 0 0 0 [[4, 286]] 1.0 2cjm CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2CJMC 1 297 298.0 ATP:1298 ATPlike Active DFGin 6.446 15.389 BLAminus -136.23, -173.15 48.46, 78.84 -90.01, 21.15 280.3, 74.36 -53.78, -24.47 in-in in 8.957 Saltbr-in 2.575 HRD-in -82.67, -49.67 67.53, 9.26 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -72.35 APE9-dihe-na -81.21, 139.76 APE8-dihe-in -48.67, 128.86 APE8-rot-in 299.02 APE67-dihe-in -54.58, -22.4 -47.31, -51.92 APE12-dist-in 13.068 APE11-dist-in 10.808 APE10-dist-in 7.009 APE9-dist-in 3.58 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 C 298 297 0 0 0 0 [[4, 286]] 1.0 2cjm CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4II5A 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.295 15.275 BLAminus -136.76, -174.67 48.15, 75.69 -89.27, 15.07 281.74, 67.11 -54.49, -30.0 in-in in 8.675 Saltbr-in 2.898 HRD-in -77.95, -58.94 72.46, 5.93 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.58, 147.66 APE9-dihe-na 74.72, 130.64 APE8-dihe-in -63.5, 139.49 APE8-rot-in 303.89 APE67-dihe-in -59.35, -27.46 -47.25, -50.52 APE12-dist-in 13.127 APE11-dist-in 10.372 APE10-dist-in 7.034 APE9-dist-in 3.344 None TPO160 TPO160 XRAY 2.15 0.2 0.226 A 298 296 0 0 0 0 [[4, 286]] 1.0 4ii5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4II5C 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.289 15.288 BLAminus -134.89, -171.63 44.93, 79.89 -96.21, 16.02 275.02, 74.95 -60.79, -24.87 in-in in 8.666 Saltbr-in 2.94 HRD-in -77.09, -52.7 69.17, 3.7 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.65, 138.88 APE9-dihe-na 85.57, 133.69 APE8-dihe-in -65.51, 139.86 APE8-rot-in 305.2 APE67-dihe-in -60.76, -27.54 -47.35, -49.81 APE12-dist-in 13.141 APE11-dist-in 10.382 APE10-dist-in 7.061 APE9-dist-in 3.387 None TPO160 TPO160 XRAY 2.15 0.2 0.226 C 298 296 0 0 0 0 [[4, 286]] 1.0 4ii5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1GY3A 1 296 298.0 ATP:1297 ATPlike Active DFGin 6.711 15.739 BLAminus -148.85, -171.85 44.28, 78.14 -91.55, 12.53 280.84, 73.84 -49.56, -35.56 in-in in 8.826 Saltbr-in 2.87 HRD-in -78.88, -56.55 74.04, 15.78 in-in-in SNCiii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.01, 152.98 APE9-dihe-na 75.99, 139.26 APE8-dihe-in -71.28, 139.34 APE8-rot-in 297.69 APE67-dihe-in -59.44, -30.42 -47.65, -49.93 APE12-dist-in 13.156 APE11-dist-in 10.678 APE10-dist-in 7.643 APE9-dist-in 3.395 None TPO160 TPO160 XRAY 2.7 0.25 0.313 A 299 296 0 0 0 0 [[4, 286]] 1.0 1gy3 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1GY3C 1 296 298.0 ATP:1298 ATPlike Active DFGin 6.824 15.376 BLAminus -159.42, -172.39 46.56, 69.8 -88.25, 18.8 278.1, 68.22 -63.28, -3.45 in-in in 8.61 Saltbr-in 3.316 HRD-in -72.89, -69.46 86.12, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.99, 145.31 APE9-dihe-na 77.28, 144.74 APE8-dihe-in -75.96, 137.92 APE8-rot-in 277.1 APE67-dihe-in -64.24, -30.46 -41.97, -49.4 APE12-dist-in 13.195 APE11-dist-in 10.636 APE10-dist-in 7.772 APE9-dist-in 3.212 None TPO160 TPO160 XRAY 2.7 0.25 0.313 C 299 296 0 0 0 0 [[4, 286]] 1.0 1gy3 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1QMZA 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.424 15.17 BLAminus -146.26, -172.65 47.53, 78.45 -93.94, 24.34 280.23, 76.95 -74.2, -4.32 in-in in 8.74 Saltbr-in 2.663 HRD-in -79.61, -61.2 70.52, 19.43 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.31, 152.76 APE9-dihe-na 72.53, 130.75 APE8-dihe-in -60.65, 130.8 APE8-rot-in 293.88 APE67-dihe-in -60.7, -26.37 -33.48, -54.72 APE12-dist-in 13.02 APE11-dist-in 10.095 APE10-dist-in 7.17 APE9-dist-in 3.235 None TPO160 TPO160 XRAY 2.2 0.22 0.28 A 299 296 0 0 0 0 [[4, 286]] 1.0 1qmz CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1QMZC 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.512 15.134 BLAminus -147.61, -169.98 41.15, 80.53 -95.52, 25.6 283.09, 73.82 -79.03, -0.31 in-in in 8.74 Saltbr-in 2.54 HRD-in -75.88, -57.22 71.34, 18.39 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.04, 148.92 APE9-dihe-na 73.46, 130.58 APE8-dihe-in -61.75, 132.61 APE8-rot-in 296.97 APE67-dihe-in -70.09, -17.52 -37.4, -48.3 APE12-dist-in 12.947 APE11-dist-in 10.103 APE10-dist-in 7.19 APE9-dist-in 3.234 None TPO160 TPO160 XRAY 2.2 0.22 0.28 C 299 296 0 0 0 0 [[4, 286]] 1.0 1qmz CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2CCHA 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.648 15.496 BLAminus -138.14, 178.31 65.58, 62.78 -86.23, 16.74 281.6, 70.81 -63.75, -23.41 in-in in 8.795 Saltbr-in 2.828 HRD-in -78.21, -56.44 71.04, 15.24 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 152.64 APE9-dihe-na 69.68, 132.94 APE8-dihe-in -57.07, 137.05 APE8-rot-in 294.63 APE67-dihe-in -60.03, -20.02 -46.03, -52.89 APE12-dist-in 13.198 APE11-dist-in 10.36 APE10-dist-in 7.208 APE9-dist-in 3.286 None TPO160 TPO160 XRAY 1.7 0.15 0.182 A 299 296 0 0 0 0 [[4, 286]] 1.0 2cch CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2CCHC 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.477 15.382 BLAminus -137.71, -178.58 51.07, 78.61 -96.17, 22.01 279.1, 72.77 -65.43, -25.94 in-in in 8.653 Saltbr-in 2.719 HRD-in -81.45, -53.09 63.51, 17.55 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.56, 136.55 APE9-dihe-na 76.27, 128.23 APE8-dihe-in -59.37, 134.24 APE8-rot-in 303.33 APE67-dihe-in -63.22, -26.6 -41.45, -49.27 APE12-dist-in 12.866 APE11-dist-in 10.056 APE10-dist-in 7.377 APE9-dist-in 3.26 None TPO160 TPO160 XRAY 1.7 0.15 0.182 C 299 296 0 0 0 0 [[4, 286]] 1.0 2cch CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2CCIA 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.459 15.372 BLAminus -128.71, -173.86 48.01, 81.43 -98.73, 25.24 282.02, 74.31 -66.86, -20.71 in-in in 8.902 Saltbr-in 3.076 HRD-in -75.27, -47.91 58.22, 13.15 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.39, 140.99 APE9-dihe-na 76.14, 131.3 APE8-dihe-in -63.2, 133.24 APE8-rot-in 305.53 APE67-dihe-in -53.35, -21.65 -35.23, -63.18 APE12-dist-in 12.958 APE11-dist-in 10.323 APE10-dist-in 7.246 APE9-dist-in 3.291 None TPO160 TPO160 XRAY 2.7 0.264 0.321 A 299 296 0 0 0 0 [[4, 286]] 1.0 2cci CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2CCIC 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.232 15.382 BLAminus -129.31, 167.15 64.1, 86.76 -100.18, 28.53 276.86, 72.85 -63.26, -37.36 in-in in 8.551 Saltbr-in 2.666 HRD-in -73.66, -47.99 63.69, 10.4 in-in-in SNCiii in-in ActLoopNT-in 3.064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.2, 138.6 APE9-dihe-na 71.13, 137.9 APE8-dihe-in -63.98, 129.66 APE8-rot-in 301.4 APE67-dihe-in -61.96, -9.78 -29.15, -60.17 APE12-dist-in 12.753 APE11-dist-in 9.767 APE10-dist-in 7.42 APE9-dist-in 3.234 None TPO160 TPO160 XRAY 2.7 0.264 0.321 C 299 296 0 0 0 0 [[4, 286]] 1.0 2cci CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESOA 1 298 298.0 W3A:60301 Allosteric Active DFGin 6.655 15.333 BLAminus -133.46, 169.39 64.14, 82.09 -97.29, 14.96 280.13, 78.42 -56.82, -27.72 in-in in 8.694 Saltbr-in 3.304 HRD-in -71.79, -59.63 73.42, 20.06 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 143.18 APE9-dihe-na 74.31, 127.7 APE8-dihe-in -57.08, 127.99 APE8-rot-in 287.92 APE67-dihe-in -62.74, -22.87 -45.7, -44.34 APE12-dist-in 12.977 APE11-dist-in 9.73 APE10-dist-in 7.242 APE9-dist-in 3.262 None TPO160 TPO160 XRAY 2.396 0.218 0.221 A 302 298 0 0 0 0 [[4, 286]] 1.0 9eso CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESYA 1 296 298.0 HH8:60601,HH8:60602 Allosteric,Type1 Active DFGin 6.914 15.445 BLAminus -139.64, -178.33 56.3, 76.8 -98.54, 32.68 277.01, 73.22 -78.73, -25.27 in-in in 8.706 Saltbr-in 3.122 HRD-in -81.47, -55.44 76.61, 11.71 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.23, 175.02 APE9-dihe-na 74.59, 128.83 APE8-dihe-in -54.03, 132.08 APE8-rot-in 290.61 APE67-dihe-in -59.72, -15.02 -41.89, -48.16 APE12-dist-in 13.107 APE11-dist-in 12.117 APE10-dist-in 7.098 APE9-dist-in 3.172 None TPO160 TPO160 XRAY 2.394 0.257 0.262 A 302 296 0 0 0 0 [[4, 286]] 1.0 9esy CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET1A 1 298 298.0 IJL:60301,IJL:60302 Allosteric,Type1 Active DFGin 6.61 15.432 BLAminus -137.66, 172.68 58.27, 87.59 -100.93, 20.0 276.6, 76.94 -60.98, -28.65 in-in in 8.734 Saltbr-in 3.047 HRD-in -76.58, -65.76 87.89, 15.93 in-in-in SNCiii in-in ActLoopNT-in 3.205 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.13, 164.18 APE9-dihe-na 77.58, 126.34 APE8-dihe-in -49.84, 134.42 APE8-rot-in 305.88 APE67-dihe-in -58.89, -21.26 -48.0, -52.41 APE12-dist-in 13.1 APE11-dist-in 12.196 APE10-dist-in 7.293 APE9-dist-in 3.194 None TPO160 TPO160 XRAY 2.394 0.221 0.228 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et1 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET2A 1 298 298.0 IJX:60301,IJX:60302 Allosteric,Type1 Active DFGin 6.679 15.451 BLAminus -141.74, 173.34 57.73, 90.3 -103.65, 24.15 276.16, 73.44 -67.69, -32.25 in-in in 8.736 Saltbr-in 3.199 HRD-in -83.89, -59.32 78.42, 17.56 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.93, 164.85 APE9-dihe-na 78.45, 121.77 APE8-dihe-in -43.83, 132.89 APE8-rot-in 303.96 APE67-dihe-in -56.19, -21.95 -48.89, -51.57 APE12-dist-in 13.137 APE11-dist-in 11.976 APE10-dist-in 6.976 APE9-dist-in 3.288 None TPO160 TPO160 XRAY 2.37 0.229 0.231 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et2 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESOC 1 296 298.0 W3A:60301,W3A:60302,W3A:60303 Allosteric,Type1,Allosteric Active DFGin 6.705 15.576 BLAminus -143.57, -178.71 50.73, 75.02 -85.85, 27.87 280.03, 72.76 -67.71, -29.24 in-in in 8.582 Saltbr-in 3.079 HRD-in -81.26, -57.04 69.4, 12.91 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.88, 143.3 APE9-dihe-na 78.39, 127.52 APE8-dihe-in -56.1, 139.77 APE8-rot-in 304.79 APE67-dihe-in -52.87, -28.83 -47.3, -55.08 APE12-dist-in 12.645 APE11-dist-in 9.983 APE10-dist-in 7.188 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.396 0.218 0.221 C 302 296 0 0 0 0 [[4, 286]] 1.0 9eso CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESQC 1 296 298.0 IT4:60301,IT4:60302,IT4:60303 Allosteric,Type1,Allosteric Active DFGin 6.624 15.291 BLAminus -137.85, -178.69 52.7, 77.3 -90.27, 19.87 278.47, 77.01 -59.18, -26.94 in-in in 8.607 Saltbr-in 2.858 HRD-in -78.68, -58.44 73.58, 9.59 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.68, 150.97 APE9-dihe-na 74.26, 123.88 APE8-dihe-in -48.22, 139.44 APE8-rot-in 303.28 APE67-dihe-in -59.57, -21.54 -47.89, -52.58 APE12-dist-in 12.948 APE11-dist-in 10.21 APE10-dist-in 6.851 APE9-dist-in 3.189 None TPO160 TPO160 XRAY 2.38 0.206 0.21 C 302 266 30 0 0 0 [[4, 286]] 1.0 9esq CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET8A 1 298 298.0 IIS:60601,IIS:60602,IIS:60603 Allosteric,Type1,Allosteric Active DFGin 6.66 15.267 BLAminus -132.18, 175.72 56.92, 87.06 -99.25, 17.56 279.65, 74.77 -56.71, -31.95 in-in in 8.83 Saltbr-in 2.915 HRD-in -79.06, -57.11 80.34, 14.99 in-in-in SNCiii in-in ActLoopNT-in 3.01 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.88, 138.7 APE9-dihe-na 86.37, 127.57 APE8-dihe-in -49.12, 131.32 APE8-rot-in 301.39 APE67-dihe-in -60.3, -18.72 -49.04, -49.16 APE12-dist-in 13.188 APE11-dist-in 10.728 APE10-dist-in 7.284 APE9-dist-in 3.31 None TPO160 TPO160 XRAY 2.31 0.226 0.242 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et8 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESSA 1 298 298.0 UUG:60601,UUG:60603,UUG:60604,UUG:60605 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.695 15.291 BLAminus -143.55, -172.69 50.57, 82.8 -101.61, 18.26 274.16, 75.73 -70.34, -22.45 in-in in 8.76 Saltbr-in 3.285 HRD-in -76.11, -53.71 67.29, 25.09 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.09, 136.89 APE9-dihe-na 78.9, 132.52 APE8-dihe-in -60.77, 137.94 APE8-rot-in 287.48 APE67-dihe-in -68.63, -13.58 -48.45, -45.96 APE12-dist-in 12.975 APE11-dist-in 10.05 APE10-dist-in 7.581 APE9-dist-in 3.313 None TPO160 TPO160 XRAY 2.44 0.212 0.219 A 302 298 0 0 0 0 [[4, 286]] 1.0 9ess CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESWA 1 294 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.515 15.297 BLAminus -143.94, 174.07 58.52, 82.55 -94.4, 25.35 278.47, 68.95 -74.76, -22.16 in-in in 8.637 Saltbr-in 3.197 HRD-in -81.26, -58.57 77.56, 16.21 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -61.44, 160.94 APE9-dihe-na 81.67, 126.4 APE8-dihe-in -51.25, 136.17 APE8-rot-in 300.7 APE67-dihe-in -59.48, -16.12 -52.59, -48.63 APE12-dist-in 12.997 APE11-dist-in 11.897 APE10-dist-in 7.023 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.38 0.233 0.239 A 302 294 0 0 0 0 [[4, 286]] 1.0 9esw CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESWC 1 296 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.576 15.209 BLAminus -137.9, -176.23 48.55, 71.41 -85.05, 25.18 283.44, 66.65 -62.35, -32.95 in-in in 8.417 Saltbr-in 2.763 HRD-in -83.58, -58.72 75.84, 9.9 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.32, 151.2 APE9-dihe-na 72.23, 131.64 APE8-dihe-in -58.77, 140.82 APE8-rot-in 312.4 APE67-dihe-in -51.92, -26.23 -42.04, -57.02 APE12-dist-in 12.776 APE11-dist-in 10.195 APE10-dist-in 6.943 APE9-dist-in 3.236 None TPO160 TPO160 XRAY 2.38 0.233 0.239 C 302 269 27 0 0 0 [[4, 286]] 1.0 9esw CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ETBA 1 298 298.0 PYZ:60601,PYZ:60602,PYZ:60604,PYZ:60606 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.68 15.57 BLAminus -134.02, 179.89 52.18, 79.05 -90.46, 32.64 275.32, 74.18 -73.39, -29.97 in-in in 8.617 Saltbr-in 3.479 HRD-in -84.14, -59.82 72.65, 14.59 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.68, 145.25 APE9-dihe-na 77.56, 126.12 APE8-dihe-in -50.85, 139.31 APE8-rot-in 306.09 APE67-dihe-in -53.89, -21.84 -51.66, -56.12 APE12-dist-in 12.679 APE11-dist-in 10.342 APE10-dist-in 7.102 APE9-dist-in 3.205 None TPO160 TPO160 XRAY 2.76 0.213 0.228 A 302 298 0 0 0 0 [[4, 286]] 1.0 9etb CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET3A 1 297 298.0 1P8:60601,1P8:60602,1P8:60603,1P8:60604,1P8:60605 Allosteric,Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.653 15.601 BLAminus -136.82, -177.27 50.45, 80.79 -92.99, 23.2 280.0, 68.99 -67.99, -23.36 in-in in 9.13 Saltbr-in 3.089 HRD-in -81.22, -55.89 79.56, 15.53 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.46, 155.27 APE9-dihe-na 71.1, 130.63 APE8-dihe-in -56.13, 132.54 APE8-rot-in 297.17 APE67-dihe-in -61.85, -18.92 -41.84, -50.03 APE12-dist-in 12.934 APE11-dist-in 10.614 APE10-dist-in 6.973 APE9-dist-in 3.165 None TPO160 TPO160 XRAY 2.34 0.185 0.221 A 302 293 4 0 0 0 [[4, 286]] 1.0 9et3 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET9A 1 297 298.0 HEW:60801,HEW:60802,HEW:60803,HEW:60804,HEW:60805 Allosteric,Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.572 15.409 BLAminus -133.96, -177.38 53.45, 84.64 -98.13, 25.94 274.26, 70.21 -74.85, -27.45 in-in in 8.735 Saltbr-in 3.059 HRD-in -78.44, -57.38 73.64, 19.34 in-in-in SNCiii in-in ActLoopNT-in 3.04 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.56, 159.19 APE9-dihe-na 80.63, 125.87 APE8-dihe-in -49.88, 140.65 APE8-rot-in 303.1 APE67-dihe-in -56.41, -19.57 -59.45, -45.78 APE12-dist-in 12.894 APE11-dist-in 11.889 APE10-dist-in 7.25 APE9-dist-in 3.35 None TPO160 TPO160 XRAY 2.494 0.225 0.246 A 302 293 4 0 0 0 [[4, 286]] 1.0 9et9 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET6A 1 298 298.0 HHQ:60301,HHQ:60302,HHQ:60303,HHQ:60304,HHQ:60305 Allosteric,Type1,Type1,Allosteric,Allosteric Active DFGin 6.558 15.4 BLAminus -138.32, 174.17 59.16, 82.89 -97.52, 24.91 277.51, 70.1 -66.81, -32.16 in-in in 8.683 Saltbr-in 3.289 HRD-in -83.72, -58.26 76.77, 19.99 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.68, 144.14 APE9-dihe-na 73.74, 127.27 APE8-dihe-in -53.01, 138.45 APE8-rot-in 290.69 APE67-dihe-in -56.0, -15.28 -49.45, -51.36 APE12-dist-in 12.736 APE11-dist-in 9.969 APE10-dist-in 7.114 APE9-dist-in 3.193 None TPO160 TPO160 XRAY 2.553 0.224 0.239 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et6 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESRA 1 296 298.0 UU1:60301,UU1:60302,UU1:60303,UU1:60304,UU1:60305 Allosteric,Type1,Type1.5_Back,Allosteric,Allosteric Active DFGin 6.484 15.309 BLAminus -137.71, 177.29 60.74, 79.75 -94.6, 19.0 278.66, 72.46 -62.93, -24.14 in-in in 8.52 Saltbr-in 2.909 HRD-in -79.16, -56.26 72.4, 14.4 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.11, 140.47 APE9-dihe-na 79.92, 128.53 APE8-dihe-in -50.99, 136.74 APE8-rot-in 298.81 APE67-dihe-in -64.23, -18.66 -49.35, -47.37 APE12-dist-in 13.04 APE11-dist-in 10.052 APE10-dist-in 7.551 APE9-dist-in 3.189 None TPO160 TPO160 XRAY 2.388 0.221 0.227 A 302 296 0 0 0 0 [[4, 286]] 1.0 9esr CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
AF-P24941-K1A 1 294 298.0 No_ligand No_ligand Active DFGin 6.87 15.12 BLAminus -140.16, 178.48 51.28, 62.88 -73.79, 18.94 281.96, 71.73 -61.73, -34.21 in-in in 8.723 Saltbr-in 2.752 HRD-in -75.84, -45.79 60.33, 14.5 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.09, 162.34 APE9-dihe-na 63.24, 130.57 APE8-dihe-in -56.84, 135.78 APE8-rot-in 300.07 APE67-dihe-in -65.59, -21.55 -45.5, -46.3 APE12-dist-in 13.242 APE11-dist-in 10.497 APE10-dist-in 6.74 APE9-dist-in 3.241 None None None AF2 -1.0 1.0 1.0 A 294 294 0 0 0 0 [[4, 286]] 1.0 AF-P24941-K1 CMGC_CDK2_HUMAN CMGC 6e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
AF-P24941-K3A 1 294 298.0 No_ligand No_ligand Active DFGin 6.701 14.889 BLAminus -138.95, 173.67 56.67, 67.47 -77.4, 14.05 281.26, 73.57 -59.19, -32.42 in-in in 8.892 Saltbr-in 2.748 HRD-in -77.57, -50.77 62.52, 12.86 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.32, 156.27 APE9-dihe-na 61.76, 135.58 APE8-dihe-in -57.29, 134.08 APE8-rot-in 293.31 APE67-dihe-in -62.83, -23.25 -42.68, -46.29 APE12-dist-in 13.022 APE11-dist-in 10.357 APE10-dist-in 6.753 APE9-dist-in 3.607 None None None AF2 -1.0 1.0 1.0 A 294 294 0 0 0 0 [[4, 286]] 1.0 AF-P24941-K3 CMGC_CDK2_HUMAN CMGC 6e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1W98A 1 297 298.0 No_ligand No_ligand Active DFGin 6.855 15.477 BLAminus -132.29, 179.27 46.85, 78.35 -90.78, 21.68 284.84, 67.75 -61.81, -18.58 in-in in 8.448 Saltbr-in 2.715 HRD-in -74.94, -55.42 68.56, 13.89 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.09, 148.28 APE9-dihe-na 71.04, 132.45 APE8-dihe-in -53.61, 138.48 APE8-rot-in 298.56 APE67-dihe-in -62.06, -26.5 -45.15, -51.76 APE12-dist-in 13.068 APE11-dist-in 10.311 APE10-dist-in 7.193 APE9-dist-in 3.398 None TPO160 TPO160 XRAY 2.15 0.185 0.246 A 298 297 0 0 0 0 [[4, 286]] 1.0 1w98 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9D0XC 1 298 298.0 No_ligand No_ligand Active DFGin 7.0 15.676 BLAminus -151.46, 172.31 59.96, 64.3 -82.59, 17.66 276.98, 76.95 -63.84, -32.64 in-in in 8.951 Saltbr-in 3.428 HRD-in -67.19, -51.2 63.12, 7.43 in-in-in SNCiii in-in ActLoopNT-in 2.592 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.32, 161.64 APE9-dihe-na 72.61, 147.92 APE8-dihe-in -61.5, 150.78 APE8-rot-in 307.57 APE67-dihe-in -61.25, -23.58 -59.12, -41.43 APE12-dist-in 13.477 APE11-dist-in 12.123 APE10-dist-in 7.571 APE9-dist-in 3.249 None TPO160 TPO160 EM 2.84 999.0 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 9d0x CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7E34A 2 298 298.0 No_ligand No_ligand Active DFGin 6.812 15.562 BLAminus -114.43, 175.14 51.52, 82.42 -93.73, 25.75 279.61, 78.85 -57.86, -47.09 in-in in 9.156 Saltbr-in 3.378 HRD-in -73.23, -37.35 52.55, 11.13 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.03, -54.07 APE9-dihe-na -126.84, 162.29 APE8-dihe-in -56.38, 143.49 APE8-rot-in 320.41 APE67-dihe-in -49.11, -31.47 -45.62, -51.01 APE12-dist-in 12.702 APE11-dist-in 9.666 APE10-dist-in 6.692 APE9-dist-in 3.735 None None None XRAY 3.19 0.254 0.3 A 298 297 0 0 0 0 [[4, 286]] 1.0 7e34 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6ATHA 17 298 298.0 No_ligand No_ligand Active DFGin 6.631 16.043 BLAminus -135.63, 173.86 60.0, 77.46 -94.47, 18.0 282.61, 72.18 -60.46, -25.8 in-in in 9.941 Saltbr-in 3.267 HRD-in -79.47, -50.85 66.96, 12.32 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.35, 169.25 APE9-dihe-na 76.92, 132.44 APE8-dihe-in -54.22, 134.87 APE8-rot-in 293.42 APE67-dihe-in -59.54, -22.0 -46.19, -51.14 APE12-dist-in 13.34 APE11-dist-in 12.372 APE10-dist-in 7.47 APE9-dist-in 3.28 None TPO160 TPO160 XRAY 1.82 0.172 0.187 A 300 278 17 0 0 0 [[4, 286]] 1.0 6ath CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5UQ1A 3 296 298.0 No_ligand No_ligand Active DFGin 6.835 15.413 BLAminus -144.0, 176.17 61.82, 68.28 -90.54, 36.8 291.1, 72.25 -74.36, -28.15 in-in in 9.413 Saltbr-in 3.088 HRD-in -82.91, -48.78 54.78, 42.34 in-in-in SNCiii in-in ActLoopNT-in 2.586 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.16, -41.16 APE9-dihe-na -160.3, 150.42 APE8-dihe-in -56.62, 128.17 APE8-rot-in 302.57 APE67-dihe-in -53.1, -29.41 -31.23, -43.06 APE12-dist-in 12.606 APE11-dist-in 8.748 APE10-dist-in 7.404 APE9-dist-in 4.537 None None None XRAY 3.201 0.208 0.261 A 301 288 6 0 0 0 [[4, 286]] 1.0 5uq1 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H24C 1 293 298.0 No_ligand No_ligand Active DFGin 6.559 15.596 BLAminus -133.49, 175.31 53.76, 89.78 -103.42, 21.65 275.45, 80.97 -62.92, -37.77 in-in in 9.12 Saltbr-in 2.85 HRD-in -91.23, -52.77 60.11, 22.43 in-in-in SNCiii in-in ActLoopNT-in 2.657 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.82, 140.74 APE9-dihe-na 80.17, 132.23 APE8-dihe-in -55.87, 134.79 APE8-rot-in 288.67 APE67-dihe-in -70.66, -27.96 -51.17, -32.98 APE12-dist-in 12.694 APE11-dist-in 10.75 APE10-dist-in 7.289 APE9-dist-in 3.425 None TPO160 TPO160 XRAY 2.5 0.212 0.27 C 303 293 0 0 0 0 [[4, 286]] 1.0 1h24 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H25A 1 293 298.0 No_ligand No_ligand Active DFGin 6.427 15.421 BLAminus -140.43, 173.99 67.64, 67.87 -81.25, 30.24 283.91, 68.58 -68.15, -35.9 in-in in 8.89 Saltbr-in 2.491 HRD-in -74.21, -51.05 67.2, 22.05 in-in-in SNCiii in-in ActLoopNT-in 3.004 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.81, 141.17 APE9-dihe-na 80.54, 129.65 APE8-dihe-in -46.03, 134.66 APE8-rot-in 297.67 APE67-dihe-in -59.41, -24.06 -45.9, -50.57 APE12-dist-in 13.403 APE11-dist-in 10.774 APE10-dist-in 7.873 APE9-dist-in 3.359 None TPO160 TPO160 XRAY 2.5 0.249 0.266 A 303 293 0 0 0 0 [[4, 286]] 1.0 1h25 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H25C 1 293 298.0 No_ligand No_ligand Active DFGin 6.343 15.678 BLAminus -141.54, -162.96 43.33, 68.33 -81.52, 26.81 277.02, 71.89 -64.81, -42.11 in-in in 8.699 Saltbr-in 3.448 HRD-in -78.87, -55.84 74.39, 8.92 in-in-in SNCiii in-in ActLoopNT-in 2.629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.27, 141.45 APE9-dihe-na 77.04, 118.84 APE8-dihe-in -50.03, 137.75 APE8-rot-in 297.84 APE67-dihe-in -53.34, -34.93 -38.84, -62.46 APE12-dist-in 12.711 APE11-dist-in 9.904 APE10-dist-in 7.219 APE9-dist-in 3.561 None TPO160 TPO160 XRAY 2.5 0.249 0.266 C 303 278 15 0 0 0 [[4, 286]] 1.0 1h25 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H26A 1 297 298.0 No_ligand No_ligand Active DFGin 6.707 15.231 BLAminus -130.74, 179.93 49.99, 80.78 -90.99, 22.63 278.59, 67.54 -55.88, -33.36 in-in in 8.513 Saltbr-in 3.0 HRD-in -87.47, -56.42 74.36, 10.84 in-in-in SNCiii in-in ActLoopNT-in 3.046 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.15, 132.37 APE9-dihe-na 88.39, 126.79 APE8-dihe-in -50.94, 133.96 APE8-rot-in 297.34 APE67-dihe-in -61.54, -24.84 -43.64, -49.19 APE12-dist-in 13.287 APE11-dist-in 10.417 APE10-dist-in 7.729 APE9-dist-in 3.129 None TPO160 TPO160 XRAY 2.24 0.219 0.268 A 303 297 0 0 0 0 [[4, 286]] 1.0 1h26 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H26C 1 297 298.0 No_ligand No_ligand Active DFGin 6.338 15.189 BLAminus -129.56, -170.99 38.09, 89.21 -96.19, 16.9 282.78, 62.93 -51.84, -27.15 in-in in 8.523 Saltbr-in 2.643 HRD-in -83.53, -52.88 73.72, 5.54 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.19, 136.75 APE9-dihe-na 80.79, 120.39 APE8-dihe-in -42.38, 138.45 APE8-rot-in 303.56 APE67-dihe-in -41.05, -33.69 -41.82, -70.9 APE12-dist-in 12.985 APE11-dist-in 10.015 APE10-dist-in 7.058 APE9-dist-in 3.268 None TPO160 TPO160 XRAY 2.24 0.219 0.268 C 303 268 29 0 0 0 [[4, 286]] 1.0 1h26 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H27A 1 297 298.0 No_ligand No_ligand Active DFGin 6.664 15.323 BLAminus -140.7, 165.59 63.58, 80.1 -95.0, 28.03 281.73, 75.96 -81.22, -9.66 in-in in 8.874 Saltbr-in 2.671 HRD-in -79.12, -57.48 75.49, 12.57 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.15, 141.66 APE9-dihe-na 83.31, 128.91 APE8-dihe-in -54.93, 124.96 APE8-rot-in 299.96 APE67-dihe-in -61.78, -15.18 -31.34, -53.69 APE12-dist-in 13.361 APE11-dist-in 10.737 APE10-dist-in 7.53 APE9-dist-in 3.422 None TPO160 TPO160 XRAY 2.2 0.229 0.269 A 303 297 0 0 0 0 [[4, 286]] 1.0 1h27 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H27C 1 297 298.0 No_ligand No_ligand Active DFGin 6.535 15.698 BLAminus -141.01, -170.97 48.58, 73.87 -90.7, 21.51 277.96, 73.03 -70.2, -20.66 in-in in 8.877 Saltbr-in 2.648 HRD-in -74.45, -56.61 75.47, 6.24 in-in-in SNCiii in-in ActLoopNT-in 2.955 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.35, -75.83 APE9-dihe-na -78.83, 147.21 APE8-dihe-in -56.74, 130.79 APE8-rot-in 291.88 APE67-dihe-in -55.62, -23.64 -43.11, -54.87 APE12-dist-in 12.872 APE11-dist-in 10.336 APE10-dist-in 6.962 APE9-dist-in 3.374 None TPO160 TPO160 XRAY 2.2 0.229 0.269 C 303 292 5 0 0 0 [[4, 286]] 1.0 1h27 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H28A 1 296 298.0 No_ligand No_ligand Active DFGin 6.384 15.718 BLAminus -153.46, -159.87 20.57, 88.57 -91.81, 11.41 271.46, 74.18 -25.9, -52.81 in-in in 8.594 Saltbr-in 2.264 HRD-in -88.8, -49.46 64.93, 15.35 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.92, 144.97 APE9-dihe-na 70.46, 137.31 APE8-dihe-in -53.73, 137.05 APE8-rot-in 271.77 APE67-dihe-in -55.48, -34.45 -39.84, -54.18 APE12-dist-in 13.112 APE11-dist-in 10.31 APE10-dist-in 7.809 APE9-dist-in 3.74 None TPO160 TPO160 XRAY 2.8 0.247 0.323 A 303 296 0 0 0 0 [[4, 286]] 1.0 1h28 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H28C 1 296 298.0 No_ligand No_ligand Active DFGin 6.686 15.554 BLAminus -122.17, -174.1 31.91, 98.77 -105.16, 25.64 276.4, 56.93 -56.63, -37.84 in-in in 8.545 Saltbr-in 2.532 HRD-in -78.4, -59.25 76.05, 21.74 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.12, 142.55 APE9-dihe-na 66.77, 132.32 APE8-dihe-in -51.48, 150.45 APE8-rot-in 338.46 APE67-dihe-in -93.0, -26.08 -62.43, -23.05 APE12-dist-in 12.871 APE11-dist-in 10.574 APE10-dist-in 7.86 APE9-dist-in 3.802 None TPO160 TPO160 XRAY 2.8 0.247 0.323 C 303 296 0 0 0 0 [[4, 286]] 1.0 1h28 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WMAA 1 296 298.0 No_ligand No_ligand Active DFGin 6.568 15.049 BLAminus -133.6, 177.0 58.82, 73.66 -85.95, 28.46 282.46, 64.37 -59.09, -39.37 in-in in 8.168 Saltbr-in 2.667 HRD-in -79.36, -47.13 63.08, 19.5 in-in-in SNCiii in-in ActLoopNT-in 3.004 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.91, 131.32 APE9-dihe-na 75.18, 124.55 APE8-dihe-in -49.63, 128.6 APE8-rot-in 283.16 APE67-dihe-in -57.29, -20.52 -38.45, -49.54 APE12-dist-in 12.747 APE11-dist-in 10.156 APE10-dist-in 7.672 APE9-dist-in 3.225 None TPO160 TPO160 XRAY 2.8 0.215 0.285 A 303 296 0 0 0 0 [[4, 286]] 1.0 2wma CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WMAC 1 296 298.0 No_ligand No_ligand Active DFGin 6.384 15.12 BLAminus -145.3, 179.74 48.13, 83.21 -99.37, 24.44 286.5, 69.16 -57.18, -31.45 in-in in 8.519 Saltbr-in 2.795 HRD-in -78.02, -42.4 57.96, 17.28 in-in-in SNCiii in-in ActLoopNT-in 2.753 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.94, 135.9 APE9-dihe-na 64.4, 130.25 APE8-dihe-in -51.81, 136.9 APE8-rot-in 318.83 APE67-dihe-in -40.81, -43.76 -29.69, -71.87 APE12-dist-in 12.702 APE11-dist-in 9.769 APE10-dist-in 7.287 APE9-dist-in 3.312 None TPO160 TPO160 XRAY 2.8 0.215 0.285 C 303 265 31 0 0 0 [[4, 286]] 1.0 2wma CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WMBA 1 296 298.0 No_ligand No_ligand Active DFGin 6.718 15.377 BLAminus -140.8, -179.02 50.24, 83.38 -90.13, 17.15 282.82, 68.9 -48.57, -40.04 in-in in 8.365 Saltbr-in 2.97 HRD-in -81.54, -49.33 66.55, 12.35 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.2, 132.18 APE9-dihe-na 83.05, 127.74 APE8-dihe-in -45.93, 124.86 APE8-rot-in 308.22 APE67-dihe-in -58.22, -25.45 -31.78, -52.64 APE12-dist-in 13.149 APE11-dist-in 10.722 APE10-dist-in 7.949 APE9-dist-in 3.244 None TPO160 TPO160 XRAY 2.6 0.23 0.296 A 303 296 0 0 0 0 [[4, 286]] 1.0 2wmb CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WMBC 1 296 298.0 No_ligand No_ligand Active DFGin 6.463 15.325 BLAminus -121.15, -178.34 51.45, 79.71 -90.23, 12.63 281.15, 73.22 -54.7, -15.77 in-in in 8.587 Saltbr-in 2.899 HRD-in -77.23, -49.1 61.52, 12.87 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.73, 141.58 APE9-dihe-na 70.76, 130.78 APE8-dihe-in -56.01, 124.97 APE8-rot-in 294.6 APE67-dihe-in -44.5, -27.37 -20.9, -71.13 APE12-dist-in 13.185 APE11-dist-in 10.089 APE10-dist-in 7.246 APE9-dist-in 3.459 None TPO160 TPO160 XRAY 2.6 0.23 0.296 C 303 266 30 0 0 0 [[4, 286]] 1.0 2wmb CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EONA 1 298 298.0 1RO:60301 Type1 Active DFGin 6.679 15.186 BLAminus -132.11, -177.66 48.8, 80.61 -94.87, 18.24 280.36, 73.55 -57.79, -34.94 in-in in 8.417 Saltbr-in 2.663 HRD-in -75.86, -51.78 66.0, 6.82 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.44, 146.03 APE9-dihe-na 76.94, 130.44 APE8-dihe-in -52.16, 130.55 APE8-rot-in 300.04 APE67-dihe-in -53.56, -30.12 -41.06, -53.76 APE12-dist-in 13.016 APE11-dist-in 9.38 APE10-dist-in 7.36 APE9-dist-in 3.322 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.4 0.22 0.254 A 300 298 0 0 0 0 [[4, 286]] 1.0 4eon CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EONC 1 297 298.0 1RO:60301 Type1 Active DFGin 6.664 14.9 BLAminus -139.87, -179.08 50.46, 76.36 -91.39, 25.02 285.74, 73.68 -64.04, -29.23 in-in in 8.338 Saltbr-in 2.47 HRD-in -73.01, -51.76 68.43, 8.79 in-in-in SNCiii in-in ActLoopNT-in 3.015 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 64.41, -8.92 APE9-dihe-na -162.15, 137.23 APE8-dihe-in -47.67, 127.68 APE8-rot-in 293.44 APE67-dihe-in -59.95, -25.08 -45.92, -47.24 APE12-dist-in 13.349 APE11-dist-in 9.451 APE10-dist-in 7.991 APE9-dist-in 3.629 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.4 0.22 0.254 C 300 297 0 0 0 0 [[4, 286]] 1.0 4eon CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOIA 1 298 298.0 1RO:60301 Type1 Active DFGin 6.572 14.887 BLAminus -136.09, 178.06 51.98, 76.26 -88.79, 18.92 282.78, 68.24 -58.67, -31.37 in-in in 8.4 Saltbr-in 2.764 HRD-in -78.65, -54.06 69.38, 12.33 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.33, 164.84 APE9-dihe-na 77.52, 131.19 APE8-dihe-in -50.1, 134.54 APE8-rot-in 303.3 APE67-dihe-in -59.45, -22.81 -46.35, -50.05 APE12-dist-in 13.354 APE11-dist-in 12.335 APE10-dist-in 7.479 APE9-dist-in 3.268 K89D,Q131E TPO160 TPO160 XRAY 2.0 0.215 0.234 A 299 294 4 0 0 0 [[4, 286]] 1.0 4eoi CMGC_CDK2_HUMAN CMGC 6.9e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2IW6A 1 295 298.0 QQ2:61296 Type1 Active DFGin 6.763 15.33 BLAminus -137.04, -179.89 52.44, 77.16 -90.65, 20.03 286.27, 71.9 -65.55, -20.57 in-in in 8.498 Saltbr-in 3.28 HRD-in -76.04, -56.62 74.08, 13.78 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.81, 140.32 APE9-dihe-na 81.92, 120.48 APE8-dihe-in -44.7, 124.8 APE8-rot-in 298.42 APE67-dihe-in -65.53, -21.14 -40.4, -43.63 APE12-dist-in 13.164 APE11-dist-in 10.454 APE10-dist-in 7.532 APE9-dist-in 3.387 K89T TPO160 TPO160 XRAY 2.3 0.231 0.287 A 302 292 3 0 0 0 [[4, 286]] 1.0 2iw6 CMGC_CDK2_HUMAN CMGC 1.8e-89 306.4 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2IW6C 1 295 298.0 QQ2:61296 Type1 Active DFGin 6.378 15.306 BLAminus -148.39, 175.51 55.38, 74.44 -89.04, 21.39 278.81, 70.78 -66.42, -21.32 in-in in 8.477 Saltbr-in 2.876 HRD-in -73.83, -61.91 76.25, 21.43 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.92, 136.02 APE9-dihe-na 64.76, 134.63 APE8-dihe-in -61.82, 140.99 APE8-rot-in 292.75 APE67-dihe-in -30.42, -30.52 -46.23, -72.37 APE12-dist-in 12.643 APE11-dist-in 9.835 APE10-dist-in 7.689 APE9-dist-in 3.426 K89T TPO160 TPO160 XRAY 2.3 0.231 0.287 C 302 295 0 0 0 0 [[4, 286]] 1.0 2iw6 CMGC_CDK2_HUMAN CMGC 1.8e-89 306.4 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2IW9A 1 297 298.0 4SP:61298 Type1 Active DFGin 6.92 15.019 BLAminus -131.25, 177.14 50.41, 78.45 -89.19, 19.11 279.3, 70.96 -63.04, -21.92 in-in in 8.627 Saltbr-in 2.664 HRD-in -76.84, -55.24 73.81, 13.13 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.48, 158.17 APE9-dihe-na 69.51, 127.63 APE8-dihe-in -55.41, 136.69 APE8-rot-in 292.83 APE67-dihe-in -55.29, -27.14 -47.71, -50.1 APE12-dist-in 13.103 APE11-dist-in 10.305 APE10-dist-in 7.154 APE9-dist-in 3.232 K89T TPO160 TPO160 XRAY 2.0 0.212 0.24 A 302 293 4 0 0 0 [[4, 286]] 1.0 2iw9 CMGC_CDK2_HUMAN CMGC 1.8e-89 306.4 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2IW9C 1 296 298.0 4SP:61297 Type1 Active DFGin 6.806 14.96 BLAminus -133.02, -178.76 46.09, 77.69 -88.26, 25.13 279.73, 69.06 -66.3, -29.69 in-in in 8.502 Saltbr-in 2.543 HRD-in -78.99, -52.42 69.26, 9.82 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.41, 143.8 APE9-dihe-na 66.28, 132.13 APE8-dihe-in -59.08, 144.46 APE8-rot-in 305.7 APE67-dihe-in -55.93, -27.46 -43.85, -53.77 APE12-dist-in 12.88 APE11-dist-in 9.931 APE10-dist-in 7.276 APE9-dist-in 3.2 K89T TPO160 TPO160 XRAY 2.0 0.212 0.24 C 302 268 28 0 0 0 [[4, 286]] 1.0 2iw9 CMGC_CDK2_HUMAN CMGC 1.8e-89 306.4 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1E9HA 1 296 298.0 INR:61298 Type1 Active DFGin 6.456 15.159 BLAminus -132.15, -179.42 51.68, 79.15 -95.02, 38.05 281.94, 68.75 -76.13, -20.19 in-in in 9.034 Saltbr-in 2.868 HRD-in -74.58, -48.32 61.21, 19.86 in-in-in SNCiii in-in ActLoopNT-in 3.102 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.15, 144.05 APE9-dihe-na 74.6, 131.04 APE8-dihe-in -55.94, 131.78 APE8-rot-in 296.32 APE67-dihe-in -63.26, -22.84 -39.36, -49.77 APE12-dist-in 12.88 APE11-dist-in 10.126 APE10-dist-in 7.306 APE9-dist-in 3.295 None TPO160 TPO160 XRAY 2.5 0.225 0.273 A 297 296 0 0 0 0 [[4, 286]] 1.0 1e9h CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1E9HC 1 296 298.0 INR:61298 Type1 Active DFGin 6.187 14.816 BLAminus -143.02, -176.13 46.31, 80.97 -97.02, 27.76 290.87, 59.63 -66.56, -7.89 in-in in 8.729 Saltbr-in 3.159 HRD-in -83.98, -58.29 69.53, 16.91 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.56, 140.46 APE9-dihe-na 71.87, 130.47 APE8-dihe-in -59.96, 126.8 APE8-rot-in 308.14 APE67-dihe-in -42.57, -36.53 -26.81, -69.86 APE12-dist-in 12.735 APE11-dist-in 9.935 APE10-dist-in 7.407 APE9-dist-in 3.337 None TPO160 TPO160 XRAY 2.5 0.225 0.273 C 297 296 0 0 0 0 [[4, 286]] 1.0 1e9h CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PKDC 1 296 298.0 UCN:60411 Type1 Active DFGin 6.463 15.32 BLAminus -135.87, 172.38 57.28, 84.68 -94.13, 24.13 279.18, 73.79 -65.7, -30.17 in-in in 8.633 Saltbr-in 3.481 HRD-in -72.06, -56.98 67.33, 21.98 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.36, 142.06 APE9-dihe-na 67.64, 128.7 APE8-dihe-in -51.48, 131.97 APE8-rot-in 292.97 APE67-dihe-in -55.98, -21.1 -45.12, -49.62 APE12-dist-in 12.786 APE11-dist-in 9.694 APE10-dist-in 7.51 APE9-dist-in 3.479 None TPO160 TPO160 XRAY 2.3 0.218 0.268 C 297 296 0 0 0 0 [[4, 286]] 1.0 1pkd CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9GLAA 2 294 298.0 YNK:301 Type1 Active DFGin 6.577 15.514 BLAminus -128.21, 178.66 58.88, 75.5 -98.38, 16.76 279.06, 75.03 -64.26, -28.43 in-in in 8.711 Saltbr-in 3.598 HRD-in -78.33, -59.03 76.12, 9.43 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.31, 151.55 APE9-dihe-na 71.55, 133.57 APE8-dihe-in -59.31, 146.48 APE8-rot-in 291.51 APE67-dihe-in -64.58, -21.93 -51.88, -49.99 APE12-dist-in 13.01 APE11-dist-in 10.323 APE10-dist-in 7.256 APE9-dist-in 3.417 E8D,K9F,I10L,T14Q,Y15F,V64I,L83M,H84E,Q85T,K88E,K89V,Q131N TPO160 TPO160 XRAY 2.18 0.203 0.249 A 298 292 1 0 0 0 [[4, 286]] 1.0 9gla CMGC_CDK2_HUMAN CMGC 8.4e-88 300.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C6TA 1 296 298.0 DT5:1297 Type1 Active DFGin 6.799 15.352 BLAminus -134.06, 177.12 50.31, 82.89 -96.13, 18.51 277.35, 75.79 -53.62, -36.05 in-in in 8.861 Saltbr-in 2.999 HRD-in -80.9, -47.67 67.76, 13.99 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.31, 144.79 APE9-dihe-na 67.5, 141.86 APE8-dihe-in -68.03, 138.16 APE8-rot-in 289.35 APE67-dihe-in -64.46, -22.44 -44.45, -50.97 APE12-dist-in 13.024 APE11-dist-in 10.235 APE10-dist-in 7.508 APE9-dist-in 3.227 None TPO160 TPO160 XRAY 2.61 0.202 0.257 A 298 296 0 0 0 0 [[4, 286]] 1.0 2c6t CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C6TC 1 296 298.0 DT5:1297 Type1 Active DFGin 6.657 15.404 BLAminus -131.57, -175.77 56.88, 80.2 -95.48, 27.17 280.99, 68.34 -80.53, -20.02 in-in in 8.739 Saltbr-in 2.887 HRD-in -82.32, -44.44 66.33, 11.16 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 146.11 APE9-dihe-na 67.63, 123.05 APE8-dihe-in -49.46, 128.41 APE8-rot-in 317.45 APE67-dihe-in -69.48, -17.34 -29.8, -51.85 APE12-dist-in 13.136 APE11-dist-in 10.777 APE10-dist-in 7.445 APE9-dist-in 3.325 None TPO160 TPO160 XRAY 2.61 0.202 0.257 C 298 296 0 0 0 0 [[4, 286]] 1.0 2c6t CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UZDA 1 296 298.0 C85:1297 Type1 Active DFGin 6.451 14.85 BLAminus -133.11, 177.08 54.86, 85.28 -101.68, 20.96 284.06, 75.81 -61.27, -24.82 in-in in 8.444 Saltbr-in 3.177 HRD-in -83.73, -45.87 61.48, 6.66 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.42, 139.46 APE9-dihe-na 69.53, 135.24 APE8-dihe-in -61.62, 135.43 APE8-rot-in 303.68 APE67-dihe-in -58.15, -22.29 -39.06, -55.04 APE12-dist-in 13.102 APE11-dist-in 10.37 APE10-dist-in 7.796 APE9-dist-in 3.079 None TPO160 TPO160 XRAY 2.72 0.211 0.269 A 298 296 0 0 0 0 [[4, 286]] 1.0 2uzd CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UZDC 1 296 298.0 C85:1297 Type1 Active DFGin 6.492 15.195 BLAminus -139.69, 179.82 41.45, 92.24 -104.15, 11.9 283.79, 67.43 -55.27, -17.29 in-in in 8.668 Saltbr-in 2.995 HRD-in -79.37, -45.87 62.75, 11.81 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.6, 143.72 APE9-dihe-na 77.42, 131.77 APE8-dihe-in -57.42, 123.98 APE8-rot-in 302.28 APE67-dihe-in -62.54, -19.9 -27.05, -62.32 APE12-dist-in 13.591 APE11-dist-in 11.063 APE10-dist-in 7.747 APE9-dist-in 3.361 None TPO160 TPO160 XRAY 2.72 0.211 0.269 C 298 296 0 0 0 0 [[4, 286]] 1.0 2uzd CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UZEA 1 296 298.0 C95:1297 Type1 Active DFGin 6.754 15.05 BLAminus -135.91, 179.99 53.98, 78.89 -93.27, 19.08 281.96, 77.01 -61.65, -33.72 in-in in 8.583 Saltbr-in 2.498 HRD-in -73.47, -51.79 67.24, 9.7 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.88, 130.34 APE9-dihe-na 76.85, 131.74 APE8-dihe-in -52.05, 131.49 APE8-rot-in 297.06 APE67-dihe-in -66.18, -19.21 -44.9, -46.95 APE12-dist-in 13.145 APE11-dist-in 10.034 APE10-dist-in 7.852 APE9-dist-in 3.338 None TPO160 TPO160 XRAY 2.4 0.198 0.243 A 298 296 0 0 0 0 [[4, 286]] 1.0 2uze CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UZEC 1 297 298.0 C95:1297 Type1 Active DFGin 6.667 14.941 BLAminus -135.15, 177.98 57.61, 75.33 -89.15, 22.31 284.49, 74.72 -59.82, -39.09 in-in in 8.537 Saltbr-in 2.571 HRD-in -68.46, -55.91 69.02, 11.45 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.35, 137.28 APE9-dihe-na 72.87, 131.3 APE8-dihe-in -52.65, 132.5 APE8-rot-in 295.51 APE67-dihe-in -60.05, -23.05 -45.59, -48.84 APE12-dist-in 13.108 APE11-dist-in 10.268 APE10-dist-in 7.788 APE9-dist-in 3.311 None TPO160 TPO160 XRAY 2.4 0.198 0.243 C 298 297 0 0 0 0 [[4, 286]] 1.0 2uze CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UZLA 1 297 298.0 C94:1297 Type1 Active DFGin 6.674 15.097 BLAminus -137.35, -179.95 48.44, 89.21 -104.87, 15.72 282.26, 80.49 -52.99, -35.26 in-in in 8.495 Saltbr-in 2.864 HRD-in -68.42, -56.55 72.05, 13.65 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.42, 144.04 APE9-dihe-na 73.79, 126.12 APE8-dihe-in -49.7, 125.07 APE8-rot-in 292.94 APE67-dihe-in -62.68, -28.49 -39.21, -47.63 APE12-dist-in 13.086 APE11-dist-in 10.392 APE10-dist-in 7.376 APE9-dist-in 3.401 None TPO160 TPO160 XRAY 2.4 0.206 0.263 A 298 297 0 0 0 0 [[4, 286]] 1.0 2uzl CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UZLC 1 297 298.0 C94:1297 Type1 Active DFGin 6.73 15.087 BLAminus -136.39, 166.29 64.07, 80.46 -92.07, 24.97 289.04, 69.12 -64.82, -35.24 in-in in 8.423 Saltbr-in 3.088 HRD-in -65.05, -58.81 69.17, 21.46 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.18, 135.19 APE9-dihe-na 79.1, 130.79 APE8-dihe-in -54.78, 130.24 APE8-rot-in 295.69 APE67-dihe-in -60.88, -24.01 -43.31, -48.83 APE12-dist-in 13.04 APE11-dist-in 10.426 APE10-dist-in 7.65 APE9-dist-in 3.401 None TPO160 TPO160 XRAY 2.4 0.206 0.263 C 298 297 0 0 0 0 [[4, 286]] 1.0 2uzl CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3EOCA 1 298 298.0 T2A:501 Type1 Active DFGin 6.683 15.232 BLAminus -139.48, 178.88 46.72, 88.4 -103.11, 38.97 280.16, 70.52 -77.56, -25.26 in-in in 8.539 Saltbr-in 3.124 HRD-in -81.23, -48.84 74.21, -2.9 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.83, 16.33 APE9-dihe-na -79.39, 169.08 APE8-dihe-in -65.52, 148.54 APE8-rot-in 299.6 APE67-dihe-in -56.16, -33.34 -71.31, -51.77 APE12-dist-in 13.805 APE11-dist-in 11.384 APE10-dist-in 7.471 APE9-dist-in 4.447 None None None XRAY 3.2 0.216 0.238 A 298 295 3 0 0 0 [[4, 286]] 1.0 3eoc CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7KJSA 1 297 298.0 WG1:60301 Type1 Active DFGin 6.941 15.435 BLAminus -129.35, 171.84 57.05, 81.38 -91.77, 23.58 280.88, 71.28 -66.78, -25.87 in-in in 8.757 Saltbr-in 2.752 HRD-in -76.08, -51.99 67.86, 12.12 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.51, -40.06 APE9-dihe-na -106.92, 150.6 APE8-dihe-in -55.34, 129.31 APE8-rot-in 282.03 APE67-dihe-in -59.24, -24.82 -35.92, -55.89 APE12-dist-in 13.361 APE11-dist-in 10.956 APE10-dist-in 7.62 APE9-dist-in 3.49 None TPO160 TPO160 XRAY 2.187 0.231 0.278 A 298 297 0 0 0 0 [[4, 286]] 1.0 7kjs CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9D0VA 1 296 298.0 A1A1H:60301 Type1 Active DFGin 7.115 15.172 BLAminus -150.53, 171.22 54.29, 76.14 -85.06, 18.83 283.94, 69.83 -60.62, -21.05 in-in in 8.45 Saltbr-in 2.712 HRD-in -75.7, -55.17 69.28, 14.04 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.78, 157.01 APE9-dihe-na 74.81, 137.48 APE8-dihe-in -61.2, 139.24 APE8-rot-in 301.92 APE67-dihe-in -58.21, -20.25 -48.4, -45.12 APE12-dist-in 13.571 APE11-dist-in 11.879 APE10-dist-in 7.373 APE9-dist-in 3.117 None TPO160 TPO160 XRAY 2.54 0.193 0.231 A 298 296 0 0 0 0 [[4, 286]] 1.0 9d0v CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9GP3A 1 298 298.0 A1IOP:60301 Type1 Active DFGin 6.91 15.356 BLAminus -140.68, 176.54 55.56, 75.28 -93.67, 27.79 286.84, 70.56 -62.0, -32.74 in-in in 8.702 Saltbr-in 3.325 HRD-in -68.03, -48.84 70.91, -9.67 in-in-in SNCiii in-in ActLoopNT-in 2.774 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.44, 166.25 APE9-dihe-na -2.05, 124.81 APE8-dihe-in -53.95, 116.42 APE8-rot-in 294.14 APE67-dihe-in -58.68, -30.68 -22.43, -40.64 APE12-dist-in 10.461 APE11-dist-in 9.942 APE10-dist-in 7.613 APE9-dist-in 3.897 None None None XRAY 2.45 0.235 0.273 A 298 298 0 0 0 0 [[4, 286]] 1.0 9gp3 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8H6TA 1 297 298.0 WZZ:60301 Type1 Active DFGin 6.882 15.455 BLAminus -134.73, 157.16 78.65, 78.35 -103.07, 24.14 283.51, 67.06 -62.14, -45.06 in-in in 8.839 Saltbr-in 3.098 HRD-in -67.48, -57.39 68.68, 6.96 in-in-in SNCiii in-in ActLoopNT-in 3.138 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.43, 172.0 APE9-dihe-na 67.71, 129.74 APE8-dihe-in -56.09, 140.94 APE8-rot-in 311.5 APE67-dihe-in -64.07, -35.96 -45.35, -50.45 APE12-dist-in 13.105 APE11-dist-in 11.361 APE10-dist-in 6.806 APE9-dist-in 3.265 None TPO160 TPO160 XRAY 3.0 0.254 0.358 A 298 297 0 0 0 0 [[4, 286]] 1.0 8h6t CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1P5EA 1 296 298.0 TBS:60301 Type1 Active DFGin 6.66 15.009 BLAminus -134.09, 174.42 61.34, 86.25 -103.57, 17.59 277.72, 74.26 -59.56, -33.53 in-in in 8.446 Saltbr-in 2.674 HRD-in -77.23, -55.8 76.04, 12.25 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.42, 162.63 APE9-dihe-na 83.55, 127.96 APE8-dihe-in -48.61, 129.88 APE8-rot-in 295.62 APE67-dihe-in -60.38, -24.79 -44.17, -46.98 APE12-dist-in 13.307 APE11-dist-in 12.314 APE10-dist-in 7.439 APE9-dist-in 3.186 None TPO160 TPO160 XRAY 2.22 0.229 0.257 A 299 296 0 0 0 0 [[4, 286]] 1.0 1p5e CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1P5EC 1 296 298.0 TBS:60302 Type1 Active DFGin 6.636 15.127 BLAminus -138.76, 179.25 54.43, 79.27 -94.7, 19.86 280.45, 76.08 -62.71, -27.5 in-in in 8.582 Saltbr-in 2.729 HRD-in -86.27, -53.86 71.16, 5.43 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -73.64, 170.31 APE9-dihe-na 70.48, 126.73 APE8-dihe-in -48.62, 130.16 APE8-rot-in 290.02 APE67-dihe-in -53.04, -25.69 -34.83, -58.58 APE12-dist-in 13.275 APE11-dist-in 12.466 APE10-dist-in 7.437 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.22 0.229 0.257 C 299 296 0 0 0 0 [[4, 286]] 1.0 1p5e CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2G9XA 1 298 298.0 NU5:60299 Type1 Active DFGin 6.827 15.048 BLAminus -124.82, 176.56 48.86, 82.2 -91.6, 23.96 281.01, 67.28 -59.48, -35.09 in-in in 8.21 Saltbr-in 2.776 HRD-in -76.43, -52.2 71.68, 15.48 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.54, 143.11 APE9-dihe-na 70.21, 137.87 APE8-dihe-in -60.95, 139.73 APE8-rot-in 303.68 APE67-dihe-in -57.36, -16.12 -54.33, -48.28 APE12-dist-in 13.159 APE11-dist-in 10.467 APE10-dist-in 7.832 APE9-dist-in 3.165 None TPO160 TPO160 XRAY 2.5 0.219 0.265 A 299 298 0 0 0 0 [[4, 286]] 1.0 2g9x CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2G9XC 1 298 298.0 NU5:60299 Type1 Active DFGin 6.517 14.993 BLAminus -139.26, -169.73 32.06, 84.31 -85.43, 21.6 274.68, 73.33 -61.2, -32.43 in-in in 8.547 Saltbr-in 2.755 HRD-in -80.68, -48.96 66.6, 15.74 in-in-in SNCiii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.08, 144.68 APE9-dihe-na 74.92, 127.5 APE8-dihe-in -54.82, 137.89 APE8-rot-in 317.46 APE67-dihe-in -61.27, -22.51 -41.55, -53.55 APE12-dist-in 12.686 APE11-dist-in 10.089 APE10-dist-in 6.669 APE9-dist-in 3.319 None TPO160 TPO160 XRAY 2.5 0.219 0.265 C 299 274 24 0 0 0 [[4, 286]] 1.0 2g9x CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3DDPA 1 297 298.0 RC8:60299 Type1 Active DFGin 6.75 15.031 BLAminus -127.95, 179.43 46.52, 81.35 -92.16, 22.27 276.35, 73.24 -63.03, -31.46 in-in in 8.333 Saltbr-in 3.081 HRD-in -82.36, -50.36 62.52, 18.48 in-in-in SNCiii in-in ActLoopNT-in 3.023 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.09, 139.36 APE9-dihe-na 73.42, 128.44 APE8-dihe-in -50.13, 134.43 APE8-rot-in 283.7 APE67-dihe-in -56.68, -9.63 -42.52, -61.86 APE12-dist-in 13.006 APE11-dist-in 10.45 APE10-dist-in 7.666 APE9-dist-in 3.419 None TPO160 TPO160 XRAY 2.7 0.21 0.27 A 299 297 0 0 0 0 [[4, 286]] 1.0 3ddp CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3DDPC 1 298 298.0 RC8:60299 Type1 Active DFGin 6.62 14.862 BLAminus -118.86, 173.91 46.65, 94.24 -104.11, 18.75 283.31, 63.56 -50.59, -37.26 in-in in 8.255 Saltbr-in 3.128 HRD-in -82.76, -47.36 68.04, 19.59 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.71, 146.82 APE9-dihe-na 70.87, 140.11 APE8-dihe-in -54.32, 132.3 APE8-rot-in 319.96 APE67-dihe-in -62.39, -29.57 -44.26, -44.66 APE12-dist-in 13.205 APE11-dist-in 10.393 APE10-dist-in 7.453 APE9-dist-in 3.231 None TPO160 TPO160 XRAY 2.7 0.21 0.27 C 299 298 0 0 0 0 [[4, 286]] 1.0 3ddp CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3DDQA 1 298 298.0 RRC:60299 Type1 Active DFGin 6.88 15.378 BLAminus -132.75, 169.79 57.41, 82.03 -94.85, 22.97 280.61, 68.74 -62.61, -27.68 in-in in 8.717 Saltbr-in 2.631 HRD-in -76.69, -57.1 75.95, 10.79 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 66.92, 123.95 APE9-dihe-na 76.33, 127.94 APE8-dihe-in -56.03, 136.54 APE8-rot-in 295.57 APE67-dihe-in -61.4, -22.16 -47.57, -46.39 APE12-dist-in 13.299 APE11-dist-in 9.21 APE10-dist-in 7.386 APE9-dist-in 3.214 None TPO160 TPO160 XRAY 1.8 0.196 0.229 A 299 296 2 0 0 0 [[4, 286]] 1.0 3ddq CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5L2WA 1 297 298.0 1QK:60900 Type1 Active DFGin 6.854 15.309 BLAminus -124.76, 175.22 50.27, 87.67 -98.37, 21.86 279.74, 69.62 -63.43, -34.97 in-in in 8.137 Saltbr-in 2.806 HRD-in -75.13, -43.71 59.18, 15.83 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.49, -41.06 APE9-dihe-na -114.17, 152.38 APE8-dihe-in -52.38, 125.85 APE8-rot-in 308.7 APE67-dihe-in -64.98, -23.56 -37.65, -52.55 APE12-dist-in 13.072 APE11-dist-in 10.555 APE10-dist-in 7.457 APE9-dist-in 3.557 None TPO160 TPO160 XRAY 2.8 0.202 0.246 A 299 297 0 0 0 0 [[4, 286]] 1.0 5l2w CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5LMKA 1 298 298.0 6ZK:60301 Type1 Active DFGin 6.747 15.226 BLAminus -137.46, 165.59 58.34, 86.4 -95.59, 20.68 280.82, 70.96 -57.68, -38.16 in-in in 8.451 Saltbr-in 2.802 HRD-in -76.51, -55.04 69.4, 17.32 in-in-in SNCiii in-in ActLoopNT-in 3.004 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -13.04, 141.69 APE9-dihe-na 70.85, 126.58 APE8-dihe-in -54.57, 132.69 APE8-rot-in 303.6 APE67-dihe-in -63.34, -26.66 -41.28, -45.6 APE12-dist-in 13.1 APE11-dist-in 9.802 APE10-dist-in 7.316 APE9-dist-in 3.345 None TPO160 TPO160 XRAY 2.4 0.213 0.249 A 299 296 2 0 0 0 [[4, 286]] 1.0 5lmk CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6GVAA 1 290 298.0 FCQ:301 Type1 Active DFGin 6.724 15.119 BLAminus -143.33, 169.59 61.57, 78.81 -90.76, 25.85 282.82, 69.6 -66.77, -22.8 in-in in 8.35 Saltbr-in 2.678 HRD-in -78.76, -53.67 66.31, 18.04 in-in-in SNCiii in-in ActLoopNT-in 2.95 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.38, 150.36 APE9-dihe-na 78.29, 127.56 APE8-dihe-in -50.69, 137.83 APE8-rot-in 302.19 APE67-dihe-in -62.38, -24.48 -48.9, -48.16 APE12-dist-in 13.062 APE11-dist-in 10.417 APE10-dist-in 7.065 APE9-dist-in 3.217 None TPO160 TPO160 XRAY 2.15 0.197 0.24 A 299 288 2 0 0 0 [[4, 286]] 1.0 6gva CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6RIJA 1 290 298.0 K4W:301 Type1 Active DFGin 6.77 15.201 BLAminus -137.79, 177.34 51.99, 79.82 -92.67, 18.49 283.09, 75.28 -64.02, -21.45 in-in in 8.325 Saltbr-in 2.755 HRD-in -78.15, -54.14 69.76, 19.75 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 154.76 APE9-dihe-na 67.96, 131.13 APE8-dihe-in -56.8, 139.72 APE8-rot-in 307.31 APE67-dihe-in -61.5, -26.7 -48.23, -49.61 APE12-dist-in 12.99 APE11-dist-in 10.148 APE10-dist-in 7.166 APE9-dist-in 3.299 None TPO160 TPO160 XRAY 2.2 0.205 0.238 A 299 290 0 0 0 0 [[4, 286]] 1.0 6rij CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6RIJC 1 290 298.0 K4W:301 Type1 Active DFGin 6.623 15.158 BLAminus -139.42, 178.25 51.12, 80.38 -90.87, 16.64 283.29, 73.43 -59.1, -28.04 in-in in 8.346 Saltbr-in 2.736 HRD-in -78.29, -50.31 71.41, 9.22 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.98, 153.02 APE9-dihe-na 70.85, 130.87 APE8-dihe-in -56.89, 139.46 APE8-rot-in 304.34 APE67-dihe-in -59.76, -21.41 -50.49, -50.26 APE12-dist-in 13.027 APE11-dist-in 10.16 APE10-dist-in 7.091 APE9-dist-in 3.275 None TPO160 TPO160 XRAY 2.2 0.205 0.238 C 299 290 0 0 0 0 [[4, 286]] 1.0 6rij CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7ACKA 1 294 298.0 R7B:60301 Type1 Active DFGin 6.6 15.093 BLAminus -137.07, 176.76 54.39, 79.26 -91.38, 21.84 284.28, 68.95 -64.22, -25.1 in-in in 8.363 Saltbr-in 2.815 HRD-in -78.41, -53.61 67.74, 12.29 in-in-in SNCiii in-in ActLoopNT-in 3.065 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.72, 155.75 APE9-dihe-na 71.06, 135.17 APE8-dihe-in -61.37, 135.3 APE8-rot-in 300.54 APE67-dihe-in -61.15, -26.3 -45.36, -47.78 APE12-dist-in 12.888 APE11-dist-in 10.064 APE10-dist-in 6.79 APE9-dist-in 3.167 None TPO160 TPO160 XRAY 1.8 0.197 0.232 A 299 294 0 0 0 0 [[4, 286]] 1.0 7ack CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7ACKC 1 294 298.0 R7B:60301 Type1 Active DFGin 6.644 15.137 BLAminus -134.26, 175.58 54.35, 80.24 -91.1, 18.3 281.67, 67.12 -62.1, -23.73 in-in in 8.426 Saltbr-in 2.768 HRD-in -86.24, -55.68 72.18, 14.84 in-in-in SNCiii in-in ActLoopNT-in 3.037 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.93, 155.94 APE9-dihe-na 74.79, 129.29 APE8-dihe-in -59.07, 138.14 APE8-rot-in 303.31 APE67-dihe-in -58.22, -26.49 -46.93, -50.39 APE12-dist-in 12.846 APE11-dist-in 10.021 APE10-dist-in 6.74 APE9-dist-in 3.244 None TPO160 TPO160 XRAY 1.8 0.197 0.232 C 299 294 0 0 0 0 [[4, 286]] 1.0 7ack CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7B7SA 1 293 298.0 T1T:301 Type1 Active DFGin 6.494 15.369 BLAminus -135.46, 168.92 55.58, 85.39 -99.09, 10.33 279.23, 76.96 -57.44, -26.5 in-in in 8.498 Saltbr-in 2.831 HRD-in -78.27, -59.79 70.57, 26.45 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.3, 147.4 APE9-dihe-na 74.12, 139.04 APE8-dihe-in -60.44, 136.44 APE8-rot-in 309.57 APE67-dihe-in -56.4, -24.99 -47.25, -49.3 APE12-dist-in 13.138 APE11-dist-in 10.151 APE10-dist-in 7.174 APE9-dist-in 3.316 None TPO160 TPO160 XRAY 2.54 0.248 0.291 A 299 287 6 0 0 0 [[4, 286]] 1.0 7b7s CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7B7SC 1 293 298.0 T1T:301 Type1 Active DFGin 6.476 15.334 BLAminus -135.29, 165.88 63.39, 80.56 -102.81, 12.28 277.58, 80.14 -58.32, -27.1 in-in in 8.407 Saltbr-in 2.871 HRD-in -80.18, -52.79 63.94, 26.31 in-in-in SNCiii in-in ActLoopNT-in 2.838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.85, 151.36 APE9-dihe-na 75.44, 137.67 APE8-dihe-in -62.06, 135.14 APE8-rot-in 315.09 APE67-dihe-in -58.38, -25.42 -44.77, -50.87 APE12-dist-in 13.067 APE11-dist-in 10.398 APE10-dist-in 7.037 APE9-dist-in 3.337 None TPO160 TPO160 XRAY 2.54 0.248 0.291 C 299 288 5 0 0 0 [[4, 286]] 1.0 7b7s CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7QHLA 1 294 298.0 D5P:301 Type1 Active DFGin 6.63 14.939 BLAminus -137.66, 172.33 61.28, 87.5 -99.75, 18.7 283.74, 70.1 -64.54, -23.39 in-in in 8.361 Saltbr-in 2.633 HRD-in -76.78, -58.13 72.67, 12.36 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.9, 152.57 APE9-dihe-na 70.74, 134.35 APE8-dihe-in -55.79, 134.07 APE8-rot-in 300.13 APE67-dihe-in -60.86, -25.16 -46.22, -50.21 APE12-dist-in 13.133 APE11-dist-in 10.364 APE10-dist-in 7.177 APE9-dist-in 3.252 None TPO160 TPO160 XRAY 1.7 0.2 0.224 A 299 285 9 0 0 0 [[4, 286]] 1.0 7qhl CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7QHLC 1 294 298.0 D5P:301 Type1 Active DFGin 6.623 14.889 BLAminus -137.6, 173.36 59.06, 89.06 -100.32, 17.76 284.01, 70.82 -62.33, -24.03 in-in in 8.302 Saltbr-in 2.687 HRD-in -77.9, -59.36 72.6, 14.8 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.03, 150.1 APE9-dihe-na 74.86, 133.85 APE8-dihe-in -55.13, 133.86 APE8-rot-in 302.35 APE67-dihe-in -60.96, -25.17 -45.08, -52.41 APE12-dist-in 13.085 APE11-dist-in 10.274 APE10-dist-in 7.137 APE9-dist-in 3.259 None TPO160 TPO160 XRAY 1.7 0.2 0.224 C 299 287 7 0 0 0 [[4, 286]] 1.0 7qhl CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8B54C 1 294 298.0 P2V:302 Type1 Active DFGin 6.514 15.099 BLAminus -122.54, 172.83 60.19, 84.09 -98.1, 19.4 281.6, 70.02 -54.41, -41.26 in-in in 8.374 Saltbr-in 2.81 HRD-in -75.35, -55.92 72.59, 17.93 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.35, 158.96 APE9-dihe-na 82.94, 134.61 APE8-dihe-in -57.65, 133.89 APE8-rot-in 307.69 APE67-dihe-in -50.27, -27.61 -42.77, -59.14 APE12-dist-in 13.319 APE11-dist-in 12.023 APE10-dist-in 7.065 APE9-dist-in 3.348 None TPO160 TPO160 XRAY 2.6 0.234 0.287 C 299 292 2 0 0 0 [[4, 286]] 1.0 8b54 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9BJCA 1 296 298.0 A1AQZ:60301 Type1 Active DFGin 6.787 15.518 BLAminus -136.33, 173.64 59.65, 68.84 -84.15, 16.43 278.49, 68.94 -62.9, -29.29 in-in in 8.694 Saltbr-in 3.03 HRD-in -78.76, -53.42 71.16, 13.59 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.37, 170.37 APE9-dihe-na 67.43, 132.76 APE8-dihe-in -52.27, 139.93 APE8-rot-in 314.84 APE67-dihe-in -57.09, -23.14 -56.38, -42.51 APE12-dist-in 13.271 APE11-dist-in 11.643 APE10-dist-in 6.906 APE9-dist-in 3.112 None TPO160 TPO160 XRAY 2.22 0.195 0.213 A 299 296 0 0 0 0 [[4, 286]] 1.0 9bjc CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3BHTA 1 298 298.0 MFR:60299 Type1 Active DFGin 6.726 14.916 BLAminus -135.33, 171.78 58.94, 90.09 -105.98, 17.26 279.11, 66.84 -57.88, -30.44 in-in in 8.524 Saltbr-in 2.721 HRD-in -76.97, -54.3 74.08, 10.3 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.38, 161.15 APE9-dihe-na 78.42, 133.04 APE8-dihe-in -54.1, 134.71 APE8-rot-in 298.86 APE67-dihe-in -59.06, -22.55 -47.47, -49.38 APE12-dist-in 13.275 APE11-dist-in 8.918 APE10-dist-in 7.502 APE9-dist-in 3.144 None TPO160 TPO160 XRAY 2.0 0.183 0.22 A 300 296 2 0 0 0 [[4, 286]] 1.0 3bht CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3BHTC 1 296 298.0 MFR:60299 Type1 Active DFGin 6.648 14.904 BLAminus -135.56, 175.64 54.19, 83.05 -97.02, 23.87 283.3, 65.03 -60.61, -30.29 in-in in 8.364 Saltbr-in 2.63 HRD-in -78.59, -55.59 71.83, 12.5 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 49.0, 126.65 APE9-dihe-na 70.83, 124.33 APE8-dihe-in -53.09, 136.38 APE8-rot-in 313.14 APE67-dihe-in -65.14, -18.51 -41.66, -49.3 APE12-dist-in 12.892 APE11-dist-in 9.398 APE10-dist-in 7.12 APE9-dist-in 3.267 None TPO160 TPO160 XRAY 2.0 0.183 0.22 C 300 270 26 0 0 0 [[4, 286]] 1.0 3bht CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3BHUA 1 298 298.0 MHR:60299 Type1 Active DFGin 6.786 14.752 BLAminus -134.75, 170.97 59.59, 89.97 -106.95, 20.16 283.64, 70.88 -60.21, -32.38 in-in in 8.351 Saltbr-in 2.647 HRD-in -76.05, -54.75 70.15, 15.56 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.89, 153.14 APE9-dihe-na 80.36, 131.09 APE8-dihe-in -55.87, 134.7 APE8-rot-in 300.34 APE67-dihe-in -60.91, -24.11 -43.0, -50.07 APE12-dist-in 13.226 APE11-dist-in 8.622 APE10-dist-in 7.792 APE9-dist-in 3.19 None TPO160 TPO160 XRAY 2.3 0.197 0.24 A 300 296 2 0 0 0 [[4, 286]] 1.0 3bhu CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3BHVA 1 298 298.0 VAR:60299 Type1 Active DFGin 6.749 15.036 BLAminus -132.56, 171.26 53.91, 86.13 -97.23, 18.97 284.34, 67.31 -58.53, -31.55 in-in in 8.469 Saltbr-in 2.954 HRD-in -79.43, -52.16 69.51, 13.01 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 2.04, 123.28 APE9-dihe-na 76.77, 132.03 APE8-dihe-in -52.21, 130.26 APE8-rot-in 301.0 APE67-dihe-in -61.5, -22.12 -41.07, -48.88 APE12-dist-in 13.177 APE11-dist-in 9.389 APE10-dist-in 7.5 APE9-dist-in 3.276 None TPO160 TPO160 XRAY 2.1 0.184 0.229 A 300 296 2 0 0 0 [[4, 286]] 1.0 3bhv CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3BHVC 1 296 298.0 VAR:60299 Type1 Active DFGin 6.717 15.117 BLAminus -131.34, 176.45 52.19, 85.58 -95.97, 17.71 279.3, 74.0 -62.28, -27.93 in-in in 8.469 Saltbr-in 2.832 HRD-in -77.61, -54.33 69.28, 11.28 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 34.08, 125.41 APE9-dihe-na 74.47, 123.34 APE8-dihe-in -47.68, 130.38 APE8-rot-in 303.56 APE67-dihe-in -62.09, -22.38 -41.46, -47.52 APE12-dist-in 12.813 APE11-dist-in 9.209 APE10-dist-in 7.16 APE9-dist-in 3.262 None TPO160 TPO160 XRAY 2.1 0.184 0.229 C 300 270 26 0 0 0 [[4, 286]] 1.0 3bhv CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3MY5A 1 298 298.0 RFZ:60300 Type1 Active DFGin 6.667 15.348 BLAminus -135.55, -178.04 53.6, 76.52 -97.01, 15.67 276.61, 75.78 -59.51, -26.48 in-in in 8.74 Saltbr-in 2.765 HRD-in -79.62, -51.44 67.18, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.67, 153.77 APE9-dihe-na 76.12, 127.46 APE8-dihe-in -56.8, 137.09 APE8-rot-in 303.01 APE67-dihe-in -62.09, -25.12 -50.14, -44.68 APE12-dist-in 13.142 APE11-dist-in 10.346 APE10-dist-in 7.108 APE9-dist-in 3.243 None TPO160 TPO160 XRAY 2.1 0.182 0.219 A 300 295 3 0 0 0 [[4, 286]] 1.0 3my5 CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3MY5C 1 296 298.0 RFZ:60301 Type1 Active DFGin 6.72 15.383 BLAminus -140.83, -171.85 49.57, 71.36 -87.98, 20.89 279.16, 71.11 -63.16, -26.32 in-in in 8.599 Saltbr-in 2.699 HRD-in -80.11, -52.55 69.91, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.93, 151.21 APE9-dihe-na 70.99, 122.72 APE8-dihe-in -51.33, 141.26 APE8-rot-in 307.41 APE67-dihe-in -61.95, -24.04 -45.65, -48.3 APE12-dist-in 12.729 APE11-dist-in 9.812 APE10-dist-in 6.813 APE9-dist-in 3.261 None TPO160 TPO160 XRAY 2.1 0.182 0.219 C 300 266 30 0 0 0 [[4, 286]] 1.0 3my5 CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3TNWA 1 298 298.0 F18:60299 Type1 Active DFGin 6.62 15.086 BLAminus -128.6, -178.26 47.86, 84.33 -97.78, 26.02 281.36, 66.37 -65.04, -21.33 in-in in 8.617 Saltbr-in 2.602 HRD-in -79.46, -53.41 71.4, 11.35 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.78, 148.35 APE9-dihe-na 78.36, 126.94 APE8-dihe-in -51.14, 135.98 APE8-rot-in 295.07 APE67-dihe-in -59.03, -26.11 -51.18, -45.17 APE12-dist-in 13.026 APE11-dist-in 10.012 APE10-dist-in 7.195 APE9-dist-in 3.205 None TPO160 TPO160 XRAY 2.0 0.188 0.227 A 300 295 3 0 0 0 [[4, 286]] 1.0 3tnw CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3TNWC 1 294 298.0 F18:60299 Type1 Active DFGin 6.338 14.965 BLAminus -134.92, -174.37 47.62, 80.87 -94.48, 22.71 276.99, 67.55 -61.56, -28.66 in-in in 8.678 Saltbr-in 2.953 HRD-in -84.06, -55.0 67.89, 14.76 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.7, 153.65 APE9-dihe-na 73.74, 131.99 APE8-dihe-in -62.58, 141.03 APE8-rot-in 293.51 APE67-dihe-in -61.78, -24.49 -48.04, -49.75 APE12-dist-in 12.955 APE11-dist-in 10.072 APE10-dist-in 6.987 APE9-dist-in 3.243 None TPO160 TPO160 XRAY 2.0 0.188 0.227 C 300 292 2 0 0 0 [[4, 286]] 1.0 3tnw CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCKA 1 297 298.0 T3E:61298 Type1 Active DFGin 6.708 16.138 BLAminus -140.99, 173.78 58.44, 83.6 -95.16, 19.86 283.39, 68.83 -69.82, -20.58 in-in in 9.421 Saltbr-in 2.873 HRD-in -80.61, -55.25 69.65, 13.56 in-in-in SNCiii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.97, 173.0 APE9-dihe-na 76.02, 130.96 APE8-dihe-in -51.63, 139.66 APE8-rot-in 300.99 APE67-dihe-in -63.31, -21.83 -54.68, -46.07 APE12-dist-in 13.796 APE11-dist-in 12.762 APE10-dist-in 7.712 APE9-dist-in 3.563 None TPO160 TPO160 XRAY 2.052 0.195 0.236 A 300 297 0 0 0 0 [[4, 286]] 1.0 4bck CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCKC 1 294 298.0 T3E:61295 Type1 Active DFGin 6.713 16.1 BLAminus -148.76, 176.83 54.28, 81.47 -98.59, 19.66 274.57, 70.83 -77.07, -1.86 in-in in 9.422 Saltbr-in 3.113 HRD-in -81.61, -58.04 70.59, 16.83 in-in-in SNCiii in-in ActLoopNT-in 3.136 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.72, 152.92 APE9-dihe-na 73.06, 130.65 APE8-dihe-in -61.38, 138.76 APE8-rot-in 293.18 APE67-dihe-in -52.53, -29.03 -44.77, -57.29 APE12-dist-in 13.473 APE11-dist-in 10.45 APE10-dist-in 7.371 APE9-dist-in 3.513 None TPO160 TPO160 XRAY 2.052 0.195 0.236 C 300 292 2 0 0 0 [[4, 286]] 1.0 4bck CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCNA 1 298 298.0 T9N:61299 Type1 Active DFGin 6.423 15.358 BLAminus -132.43, 173.08 59.42, 82.6 -96.18, 22.57 281.43, 68.76 -64.84, -22.05 in-in in 8.698 Saltbr-in 2.729 HRD-in -81.55, -53.36 72.5, 10.85 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.04, 151.85 APE9-dihe-na 74.21, 127.37 APE8-dihe-in -54.17, 135.78 APE8-rot-in 301.89 APE67-dihe-in -57.52, -26.56 -44.55, -50.59 APE12-dist-in 13.181 APE11-dist-in 10.34 APE10-dist-in 7.243 APE9-dist-in 3.172 None TPO160 TPO160 XRAY 2.1 0.186 0.219 A 300 296 2 0 0 0 [[4, 286]] 1.0 4bcn CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCNC 1 294 298.0 T9N:61296 Type1 Active DFGin 6.348 15.366 BLAminus -138.9, 178.12 52.91, 85.38 -99.92, 21.79 276.63, 71.1 -66.78, -15.26 in-in in 8.773 Saltbr-in 2.693 HRD-in -81.41, -55.77 72.05, 12.07 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.57, 152.97 APE9-dihe-na 72.05, 129.38 APE8-dihe-in -57.95, 136.49 APE8-rot-in 299.74 APE67-dihe-in -57.16, -29.63 -40.31, -55.01 APE12-dist-in 13.049 APE11-dist-in 10.265 APE10-dist-in 7.088 APE9-dist-in 3.165 None TPO160 TPO160 XRAY 2.1 0.186 0.219 C 300 294 0 0 0 0 [[4, 286]] 1.0 4bcn CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCOA 1 298 298.0 T6Q:61299 Type1 Active DFGin 6.474 15.117 BLAminus -135.79, 171.97 56.93, 82.69 -96.39, 24.73 280.25, 67.27 -60.9, -26.66 in-in in 8.492 Saltbr-in 2.643 HRD-in -81.64, -50.15 69.2, 12.85 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.17, 153.87 APE9-dihe-na 75.41, 126.9 APE8-dihe-in -55.82, 131.29 APE8-rot-in 296.78 APE67-dihe-in -57.59, -24.46 -39.45, -52.38 APE12-dist-in 13.008 APE11-dist-in 10.254 APE10-dist-in 7.069 APE9-dist-in 3.179 None TPO160 TPO160 XRAY 2.05 0.191 0.226 A 300 298 0 0 0 0 [[4, 286]] 1.0 4bco CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCOC 1 296 298.0 T6Q:61298 Type1 Active DFGin 6.366 15.169 BLAminus -138.07, 175.97 55.78, 82.31 -98.44, 30.3 281.46, 70.87 -70.2, -23.66 in-in in 8.681 Saltbr-in 2.709 HRD-in -83.59, -54.01 73.46, 6.77 in-in-in SNCiii in-in ActLoopNT-in 3.01 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.63, 154.6 APE9-dihe-na 71.04, 127.33 APE8-dihe-in -59.71, 136.46 APE8-rot-in 300.15 APE67-dihe-in -53.39, -26.5 -38.01, -58.97 APE12-dist-in 12.803 APE11-dist-in 9.889 APE10-dist-in 6.916 APE9-dist-in 3.142 None TPO160 TPO160 XRAY 2.05 0.191 0.226 C 300 269 27 0 0 0 [[4, 286]] 1.0 4bco CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCPA 1 298 298.0 T3C:61299 Type1 Active DFGin 6.533 15.191 BLAminus -134.13, 171.23 58.95, 82.45 -95.65, 26.87 280.18, 67.61 -65.02, -23.04 in-in in 8.481 Saltbr-in 2.732 HRD-in -79.81, -52.77 71.84, 11.29 in-in-in SNCiii in-in ActLoopNT-in 3.036 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.96, 155.67 APE9-dihe-na 72.11, 128.19 APE8-dihe-in -58.21, 133.91 APE8-rot-in 298.79 APE67-dihe-in -52.89, -28.0 -40.02, -53.78 APE12-dist-in 12.939 APE11-dist-in 10.283 APE10-dist-in 6.98 APE9-dist-in 3.128 None TPO160 TPO160 XRAY 2.26 0.183 0.217 A 300 298 0 0 0 0 [[4, 286]] 1.0 4bcp CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCPC 1 296 298.0 T3C:61297 Type1 Active DFGin 6.403 15.263 BLAminus -138.65, 173.95 55.78, 79.54 -94.55, 33.05 285.17, 67.29 -71.14, -20.19 in-in in 8.796 Saltbr-in 2.682 HRD-in -80.06, -56.76 72.61, 10.41 in-in-in SNCiii in-in ActLoopNT-in 3.065 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.86, 153.55 APE9-dihe-na 70.9, 126.48 APE8-dihe-in -52.55, 138.72 APE8-rot-in 308.97 APE67-dihe-in -53.33, -25.64 -40.93, -57.86 APE12-dist-in 12.705 APE11-dist-in 9.816 APE10-dist-in 6.736 APE9-dist-in 3.207 None TPO160 TPO160 XRAY 2.26 0.183 0.217 C 300 267 29 0 0 0 [[4, 286]] 1.0 4bcp CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9OB2A 1 298 298.0 A1CAE:301 Type1 Active DFGin 6.973 15.819 BLAminus -140.58, 171.08 58.52, 79.46 -94.8, 23.07 280.05, 75.23 -67.38, -31.52 in-in in 9.069 Saltbr-in 2.942 HRD-in -78.96, -52.8 68.26, 15.96 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.79, 173.58 APE9-dihe-na 68.76, 138.4 APE8-dihe-in -56.87, 148.48 APE8-rot-in 309.82 APE67-dihe-in -62.62, -24.47 -58.46, -45.68 APE12-dist-in 13.164 APE11-dist-in 12.165 APE10-dist-in 7.322 APE9-dist-in 3.24 None TPO160 TPO160 XRAY 2.12 0.222 0.254 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob2 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9OB3A 1 298 298.0 A1CAH:301 Type1 Active DFGin 6.944 15.38 BLAminus -140.37, 165.75 61.33, 84.57 -97.71, 21.68 278.93, 69.47 -68.71, -23.45 in-in in 8.689 Saltbr-in 2.745 HRD-in -78.08, -52.73 68.36, 12.87 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.02, 171.78 APE9-dihe-na 72.31, 133.34 APE8-dihe-in -55.78, 146.1 APE8-rot-in 297.78 APE67-dihe-in -63.1, -23.49 -57.09, -47.96 APE12-dist-in 13.138 APE11-dist-in 12.222 APE10-dist-in 7.311 APE9-dist-in 3.233 None TPO160 TPO160 XRAY 1.98 0.22 0.244 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob3 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9OB4A 1 298 298.0 A1CAF:301 Type1 Active DFGin 7.07 15.433 BLAminus -140.78, 171.16 58.81, 81.21 -94.48, 18.25 279.35, 70.51 -60.63, -24.89 in-in in 8.702 Saltbr-in 2.578 HRD-in -77.49, -52.8 70.85, 9.99 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.4, 171.78 APE9-dihe-na 71.79, 138.58 APE8-dihe-in -59.97, 144.28 APE8-rot-in 298.9 APE67-dihe-in -65.05, -23.77 -53.99, -47.04 APE12-dist-in 13.149 APE11-dist-in 12.232 APE10-dist-in 7.357 APE9-dist-in 3.261 None TPO160 TPO160 XRAY 1.95 0.211 0.251 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob4 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9OB5A 1 298 298.0 A1CAG:301 Type1 Active DFGin 6.842 15.672 BLAminus -135.5, 170.11 58.28, 87.23 -101.1, 23.21 280.56, 72.89 -67.04, -29.15 in-in in 9.008 Saltbr-in 2.912 HRD-in -81.14, -52.75 70.15, 14.96 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.91, 175.18 APE9-dihe-na 68.51, 138.98 APE8-dihe-in -58.79, 149.16 APE8-rot-in 311.25 APE67-dihe-in -63.48, -24.66 -60.24, -43.57 APE12-dist-in 13.08 APE11-dist-in 12.166 APE10-dist-in 7.29 APE9-dist-in 3.272 None TPO160 TPO160 XRAY 2.1 0.234 0.255 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob5 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9OB6A 1 298 298.0 A1CAI:301 Type1 Active DFGin 6.893 15.837 BLAminus -137.4, 170.01 57.92, 85.37 -99.98, 24.43 280.46, 72.7 -67.68, -29.62 in-in in 9.104 Saltbr-in 2.826 HRD-in -79.8, -52.56 69.42, 15.05 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -92.25, 173.7 APE9-dihe-na 68.67, 136.82 APE8-dihe-in -57.31, 149.69 APE8-rot-in 308.11 APE67-dihe-in -62.59, -22.53 -59.33, -46.2 APE12-dist-in 13.087 APE11-dist-in 12.103 APE10-dist-in 7.264 APE9-dist-in 3.249 None TPO160 TPO160 XRAY 2.0 0.228 0.256 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob6 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCMA 1 296 298.0 T7Z:61297 Type1 Active DFGin 6.519 15.338 BLAminus -139.66, 174.2 58.72, 79.02 -93.6, 24.76 282.71, 70.29 -67.74, -29.26 in-in in 8.826 Saltbr-in 2.802 HRD-in -76.71, -53.42 71.43, 16.28 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.32, 150.29 APE9-dihe-na 79.09, 129.96 APE8-dihe-in -55.49, 136.02 APE8-rot-in 301.59 APE67-dihe-in -59.49, -23.97 -43.8, -51.06 APE12-dist-in 13.192 APE11-dist-in 10.409 APE10-dist-in 7.191 APE9-dist-in 3.251 None TPO160 TPO160 XRAY 2.45 0.198 0.258 A 301 293 3 0 0 0 [[4, 286]] 1.0 4bcm CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCMC 1 294 298.0 T7Z:61295 Type1 Active DFGin 6.195 15.206 BLAminus -144.88, 174.61 58.31, 79.88 -94.05, 24.48 286.22, 64.67 -52.96, -36.75 in-in in 8.929 Saltbr-in 2.868 HRD-in -78.72, -52.42 66.78, 17.05 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.18, 152.85 APE9-dihe-na 70.08, 132.37 APE8-dihe-in -63.98, 114.75 APE8-rot-in 298.59 APE67-dihe-in -41.3, -28.08 -11.16, -73.96 APE12-dist-in 13.079 APE11-dist-in 10.227 APE10-dist-in 7.136 APE9-dist-in 3.181 None TPO160 TPO160 XRAY 2.45 0.198 0.258 C 301 294 0 0 0 0 [[4, 286]] 1.0 4bcm CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCQA 1 295 298.0 TJF:61296 Type1 Active DFGin 6.591 15.979 BLAminus -145.97, 170.46 62.82, 84.99 -99.38, 29.59 282.23, 71.6 -71.19, -18.61 in-in in 9.404 Saltbr-in 3.453 HRD-in -85.05, -58.94 78.36, 12.61 in-in-in SNCiii in-in ActLoopNT-in 3.147 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.8, 176.97 APE9-dihe-na 69.33, 133.29 APE8-dihe-in -55.38, 139.69 APE8-rot-in 304.09 APE67-dihe-in -55.84, -22.0 -49.63, -50.65 APE12-dist-in 13.625 APE11-dist-in 12.543 APE10-dist-in 7.498 APE9-dist-in 3.511 None TPO160 TPO160 XRAY 2.4 0.217 0.252 A 301 290 5 0 0 0 [[4, 286]] 1.0 4bcq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BCQC 1 294 298.0 TJF:61295 Type1 Active DFGin 6.54 16.003 BLAminus -147.36, 170.23 59.21, 86.27 -98.9, 28.16 278.44, 72.82 -71.37, -12.42 in-in in 9.598 Saltbr-in 3.261 HRD-in -88.13, -59.99 74.18, 19.51 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.48, 157.26 APE9-dihe-na 69.58, 129.95 APE8-dihe-in -57.66, 135.49 APE8-rot-in 301.27 APE67-dihe-in -62.84, -20.05 -48.44, -46.81 APE12-dist-in 13.54 APE11-dist-in 10.682 APE10-dist-in 7.689 APE9-dist-in 3.66 None TPO160 TPO160 XRAY 2.4 0.217 0.252 C 301 292 2 0 0 0 [[4, 286]] 1.0 4bcq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OGUA 1 297 298.0 ST8:61298 Type1 Active DFGin 6.622 15.169 BLAminus -132.49, 178.72 58.24, 82.71 -102.92, 24.85 272.7, 69.89 -74.09, -24.68 in-in in 8.584 Saltbr-in 2.711 HRD-in -83.59, -50.74 65.24, 16.56 in-in-in SNCiii in-in ActLoopNT-in 2.822 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.85, 140.53 APE9-dihe-na 72.4, 128.48 APE8-dihe-in -54.32, 130.77 APE8-rot-in 295.27 APE67-dihe-in -62.29, -22.87 -28.24, -54.36 APE12-dist-in 13.216 APE11-dist-in 10.607 APE10-dist-in 7.764 APE9-dist-in 3.181 None TPO160 TPO160 XRAY 2.6 0.201 0.26 A 302 294 3 0 0 0 [[4, 286]] 1.0 1ogu CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OGUC 1 296 298.0 ST8:61297 Type1 Active DFGin 6.459 15.113 BLAminus -132.86, -172.42 44.38, 86.03 -97.68, 18.4 278.98, 66.1 -53.35, -25.74 in-in in 8.553 Saltbr-in 2.899 HRD-in -78.38, -50.69 67.57, 3.92 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.31, 136.82 APE9-dihe-na 72.62, 130.48 APE8-dihe-in -52.92, 126.38 APE8-rot-in 293.43 APE67-dihe-in -53.23, -26.2 -23.04, -62.3 APE12-dist-in 13.06 APE11-dist-in 10.203 APE10-dist-in 7.289 APE9-dist-in 3.21 None TPO160 TPO160 XRAY 2.6 0.201 0.26 C 302 270 26 0 0 0 [[4, 286]] 1.0 1ogu CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OI9A 1 296 298.0 N20:61298 Type1 Active DFGin 6.859 14.992 BLAminus -137.09, 176.73 49.35, 80.06 -92.0, 19.15 280.43, 70.88 -55.63, -24.85 in-in in 8.466 Saltbr-in 2.487 HRD-in -86.15, -51.32 70.37, 8.74 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.94, 147.34 APE9-dihe-na 76.84, 129.62 APE8-dihe-in -56.61, 135.02 APE8-rot-in 291.15 APE67-dihe-in -62.67, -21.75 -47.93, -44.41 APE12-dist-in 13.106 APE11-dist-in 10.324 APE10-dist-in 7.42 APE9-dist-in 3.152 None TPO160 TPO160 XRAY 2.1 0.233 0.276 A 302 295 1 0 0 0 [[4, 286]] 1.0 1oi9 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OI9C 1 296 298.0 N20:61298 Type1 Active DFGin 6.633 14.824 BLAminus -152.07, 175.55 44.19, 85.97 -92.48, 17.16 278.61, 70.04 -60.62, -28.89 in-in in 8.502 Saltbr-in 2.546 HRD-in -78.68, -51.26 65.59, 16.91 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.76, 146.75 APE9-dihe-na 61.54, 130.0 APE8-dihe-in -61.63, 122.83 APE8-rot-in 314.38 APE67-dihe-in -56.62, -2.9 -14.2, -63.27 APE12-dist-in 12.796 APE11-dist-in 9.998 APE10-dist-in 7.209 APE9-dist-in 3.18 None TPO160 TPO160 XRAY 2.1 0.233 0.276 C 302 296 0 0 0 0 [[4, 286]] 1.0 1oi9 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OIUA 1 297 298.0 N76:61298 Type1 Active DFGin 6.759 15.012 BLAminus -137.34, 178.77 51.55, 78.03 -91.83, 21.45 278.56, 70.28 -62.46, -30.57 in-in in 8.53 Saltbr-in 2.415 HRD-in -81.02, -53.81 70.44, 13.29 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.36, 148.76 APE9-dihe-na 73.2, 130.68 APE8-dihe-in -54.69, 132.3 APE8-rot-in 294.13 APE67-dihe-in -60.22, -23.68 -44.08, -49.04 APE12-dist-in 13.004 APE11-dist-in 10.218 APE10-dist-in 7.221 APE9-dist-in 3.127 None TPO160 TPO160 XRAY 2.0 0.216 0.253 A 302 294 3 0 0 0 [[4, 286]] 1.0 1oiu CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OIUC 1 296 298.0 N76:61298 Type1 Active DFGin 6.569 15.039 BLAminus -135.76, -176.9 45.26, 77.47 -86.34, 20.34 277.13, 73.62 -64.22, -25.41 in-in in 8.601 Saltbr-in 2.744 HRD-in -77.64, -55.36 70.75, 11.6 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.54, 139.18 APE9-dihe-na 71.75, 132.71 APE8-dihe-in -59.2, 139.16 APE8-rot-in 301.58 APE67-dihe-in -62.98, -21.95 -42.64, -49.62 APE12-dist-in 12.838 APE11-dist-in 9.801 APE10-dist-in 7.366 APE9-dist-in 3.178 None TPO160 TPO160 XRAY 2.0 0.216 0.253 C 302 265 31 0 0 0 [[4, 286]] 1.0 1oiu CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OIYA 1 296 298.0 N41:61298 Type1 Active DFGin 6.66 14.996 BLAminus -127.48, -178.66 52.26, 79.06 -92.28, 22.77 282.01, 74.59 -64.24, -22.66 in-in in 8.467 Saltbr-in 2.706 HRD-in -89.29, -51.55 80.68, 13.24 in-in-in SNCiii in-in ActLoopNT-in 2.769 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.42, 136.82 APE9-dihe-na 84.96, 128.45 APE8-dihe-in -46.78, 134.06 APE8-rot-in 292.24 APE67-dihe-in -64.62, -24.9 -49.77, -41.61 APE12-dist-in 13.259 APE11-dist-in 10.397 APE10-dist-in 7.764 APE9-dist-in 3.253 None TPO160 TPO160 XRAY 2.4 0.244 0.309 A 302 293 3 0 0 0 [[4, 286]] 1.0 1oiy CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OIYC 1 296 298.0 N41:61298 Type1 Active DFGin 6.606 14.88 BLAminus -139.86, 175.08 52.38, 94.67 -103.32, 15.66 281.85, 70.39 -49.31, -37.57 in-in in 8.456 Saltbr-in 3.044 HRD-in -70.25, -62.2 71.8, 24.48 in-in-in SNCiii in-in ActLoopNT-in 2.694 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.13, 140.54 APE9-dihe-na 71.07, 126.83 APE8-dihe-in -55.12, 129.08 APE8-rot-in 283.04 APE67-dihe-in -48.74, -27.07 -21.27, -76.65 APE12-dist-in 13.043 APE11-dist-in 10.047 APE10-dist-in 7.374 APE9-dist-in 3.092 None TPO160 TPO160 XRAY 2.4 0.244 0.309 C 302 296 0 0 0 0 [[4, 286]] 1.0 1oiy CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFNA 1 297 298.0 JYM:61298 Type1 Active DFGin 6.593 15.176 BLAminus -142.97, 176.43 52.3, 83.58 -94.67, 16.21 284.19, 69.15 -57.24, -25.79 in-in in 8.59 Saltbr-in 3.015 HRD-in -81.6, -56.87 73.91, 13.78 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.94, 143.63 APE9-dihe-na 73.87, 131.35 APE8-dihe-in -51.67, 139.86 APE8-rot-in 296.91 APE67-dihe-in -58.1, -27.15 -50.49, -50.55 APE12-dist-in 13.008 APE11-dist-in 10.344 APE10-dist-in 7.67 APE9-dist-in 3.207 None TPO160 TPO160 XRAY 2.2 0.199 0.241 A 302 294 3 0 0 0 [[4, 286]] 1.0 4cfn CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFNC 1 294 298.0 JYM:61295 Type1 Active DFGin 6.426 14.837 BLAminus -142.53, 176.43 51.74, 85.66 -98.29, 18.68 281.06, 70.93 -56.1, -22.8 in-in in 8.483 Saltbr-in 3.031 HRD-in -82.46, -51.56 66.87, 14.45 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.99, 139.49 APE9-dihe-na 72.89, 132.9 APE8-dihe-in -53.97, 138.58 APE8-rot-in 296.44 APE67-dihe-in -57.72, -29.08 -49.72, -50.78 APE12-dist-in 13.064 APE11-dist-in 10.07 APE10-dist-in 7.803 APE9-dist-in 3.227 None TPO160 TPO160 XRAY 2.2 0.199 0.241 C 302 294 0 0 0 0 [[4, 286]] 1.0 4cfn CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6GUBA 1 296 298.0 F9Z:60301 Type1 Active DFGin 6.574 14.893 BLAminus -133.39, -177.02 49.15, 84.77 -95.33, 26.44 284.0, 69.47 -66.54, -24.37 in-in in 8.932 Saltbr-in 2.781 HRD-in -82.81, -48.2 63.91, 17.46 in-in-in SNCiii in-in ActLoopNT-in 3.12 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.17, -71.28 APE9-dihe-na -85.68, 156.21 APE8-dihe-in -56.12, 137.27 APE8-rot-in 295.43 APE67-dihe-in -58.87, -25.5 -49.04, -50.47 APE12-dist-in 13.286 APE11-dist-in 10.474 APE10-dist-in 7.574 APE9-dist-in 3.498 None TPO160 TPO160 XRAY 2.52 0.198 0.238 A 302 293 3 0 0 0 [[4, 286]] 1.0 6gub CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6GUBC 1 296 298.0 F9Z:60301 Type1 Active DFGin 6.543 15.025 BLAminus -133.23, -174.26 46.89, 85.25 -95.4, 27.01 280.96, 69.33 -67.09, -24.13 in-in in 8.886 Saltbr-in 2.766 HRD-in -82.92, -48.9 62.29, 18.94 in-in-in SNCiii in-in ActLoopNT-in 3.12 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.8, -72.83 APE9-dihe-na -86.19, 154.73 APE8-dihe-in -58.36, 138.73 APE8-rot-in 303.89 APE67-dihe-in -59.01, -27.57 -43.52, -51.38 APE12-dist-in 12.959 APE11-dist-in 10.553 APE10-dist-in 7.276 APE9-dist-in 3.553 None TPO160 TPO160 XRAY 2.52 0.198 0.238 C 302 291 5 0 0 0 [[4, 286]] 1.0 6gub CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6GUCA 1 296 298.0 SU9:60301 Type1 Active DFGin 6.973 15.27 BLAminus -136.48, 168.46 59.83, 87.4 -95.55, 17.68 283.77, 73.7 -70.07, -21.28 in-in in 8.605 Saltbr-in 2.995 HRD-in -78.14, -56.76 74.58, 14.16 in-in-in SNCiii in-in ActLoopNT-in 3.077 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.08, 164.22 APE9-dihe-na 82.25, 131.29 APE8-dihe-in -49.82, 131.18 APE8-rot-in 295.31 APE67-dihe-in -63.1, -17.25 -48.27, -47.54 APE12-dist-in 13.479 APE11-dist-in 12.482 APE10-dist-in 7.719 APE9-dist-in 3.315 None TPO160 TPO160 XRAY 2.0 0.193 0.223 A 302 291 5 0 0 0 [[4, 286]] 1.0 6guc CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6GUCC 1 296 298.0 SU9:60301 Type1 Active DFGin 6.908 15.265 BLAminus -133.88, 171.8 59.27, 85.55 -96.14, 18.38 283.75, 72.67 -65.8, -24.99 in-in in 8.617 Saltbr-in 2.943 HRD-in -77.5, -55.72 68.85, 17.91 in-in-in SNCiii in-in ActLoopNT-in 3.077 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.23, 146.05 APE9-dihe-na 73.9, 127.31 APE8-dihe-in -45.15, 131.88 APE8-rot-in 300.07 APE67-dihe-in -61.56, -19.13 -46.74, -49.91 APE12-dist-in 13.139 APE11-dist-in 10.3 APE10-dist-in 7.209 APE9-dist-in 3.388 None TPO160 TPO160 XRAY 2.0 0.193 0.223 C 302 296 0 0 0 0 [[4, 286]] 1.0 6guc CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6GUEC 1 296 298.0 FB8:60301 Type1 Active DFGin 6.647 15.509 BLAminus -137.19, 176.14 51.03, 83.04 -90.71, 17.34 281.18, 72.33 -60.74, -26.78 in-in in 8.738 Saltbr-in 2.644 HRD-in -81.44, -55.33 72.3, 12.6 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -85.0, 169.8 APE9-dihe-na 75.79, 127.44 APE8-dihe-in -45.53, 131.47 APE8-rot-in 302.03 APE67-dihe-in -60.29, -20.12 -46.05, -47.88 APE12-dist-in 13.231 APE11-dist-in 12.427 APE10-dist-in 7.227 APE9-dist-in 3.327 None TPO160 TPO160 XRAY 1.99 0.198 0.234 C 302 288 8 0 0 0 [[4, 286]] 1.0 6gue CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6GUFA 1 298 298.0 23D:60301 Type1 Active DFGin 6.774 15.293 BLAminus -136.48, -179.42 60.5, 81.44 -99.76, 28.15 284.82, 73.53 -62.92, -40.56 in-in in 8.646 Saltbr-in 3.324 HRD-in -59.96, -71.76 90.26, -6.29 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.04, 148.55 APE9-dihe-na 70.93, 137.33 APE8-dihe-in -58.72, 140.1 APE8-rot-in 293.64 APE67-dihe-in -64.27, -24.0 -45.62, -49.06 APE12-dist-in 13.023 APE11-dist-in 10.496 APE10-dist-in 7.369 APE9-dist-in 3.095 None TPO160 TPO160 XRAY 2.65 0.205 0.255 A 302 295 3 0 0 0 [[4, 286]] 1.0 6guf CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6GUFC 1 297 298.0 23D:60301 Type1 Active DFGin 6.746 15.266 BLAminus -135.63, -175.55 48.4, 82.88 -93.3, 27.13 285.35, 72.61 -62.17, -42.75 in-in in 8.586 Saltbr-in 3.342 HRD-in -80.32, -45.78 56.89, 22.74 in-in-in SNCiii in-in ActLoopNT-in 3.123 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 39.73, -119.25 APE9-dihe-na -76.13, 148.61 APE8-dihe-in -55.68, 139.82 APE8-rot-in 314.94 APE67-dihe-in -62.54, -25.92 -42.68, -48.85 APE12-dist-in 12.677 APE11-dist-in 9.575 APE10-dist-in 7.221 APE9-dist-in 3.473 None TPO160 TPO160 XRAY 2.65 0.205 0.255 C 302 297 0 0 0 0 [[4, 286]] 1.0 6guf CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESNA 1 294 298.0 UUS:60301 Type1 Active DFGin 6.648 15.165 BLAminus -134.79, 167.89 66.46, 85.3 -102.62, 30.84 284.71, 69.4 -77.75, -19.14 in-in in 8.633 Saltbr-in 3.078 HRD-in -81.61, -56.98 76.51, 12.0 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.95, 163.17 APE9-dihe-na 79.36, 120.08 APE8-dihe-in -44.61, 133.81 APE8-rot-in 298.13 APE67-dihe-in -63.84, -16.28 -49.11, -47.0 APE12-dist-in 12.918 APE11-dist-in 11.896 APE10-dist-in 7.116 APE9-dist-in 3.213 None TPO160 TPO160 XRAY 2.393 0.209 0.213 A 302 294 0 0 0 0 [[4, 286]] 1.0 9esn CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESPA 1 289 298.0 UUV:61501 Type1 Active DFGin 6.606 15.358 BLAminus -132.48, 173.77 61.5, 85.32 -100.79, 26.42 280.93, 74.5 -68.1, -27.93 in-in in 8.731 Saltbr-in 3.142 HRD-in -80.19, -56.19 71.67, 19.17 in-in-in SNCiii in-in ActLoopNT-in 3.106 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.09, 167.9 APE9-dihe-na 77.78, 132.7 APE8-dihe-in -56.52, 135.5 APE8-rot-in 293.34 APE67-dihe-in -59.37, -23.33 -49.92, -46.56 APE12-dist-in 13.039 APE11-dist-in 12.06 APE10-dist-in 7.239 APE9-dist-in 3.277 None TPO160 TPO160 XRAY 2.381 0.209 0.212 A 302 289 0 0 0 0 [[4, 286]] 1.0 9esp CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESPC 1 296 298.0 UUV:60501 Type1 Active DFGin 6.645 15.343 BLAminus -131.05, -177.65 50.95, 84.02 -94.43, 20.18 280.44, 67.59 -56.35, -37.01 in-in in 8.49 Saltbr-in 2.8 HRD-in -80.67, -58.91 74.42, 12.98 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 143.12 APE9-dihe-na 80.05, 122.59 APE8-dihe-in -48.25, 143.39 APE8-rot-in 304.08 APE67-dihe-in -52.08, -27.79 -51.89, -53.35 APE12-dist-in 12.874 APE11-dist-in 10.055 APE10-dist-in 7.025 APE9-dist-in 3.174 None TPO160 TPO160 XRAY 2.381 0.209 0.212 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esp CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESUA 1 298 298.0 IJU:60301 Type1 Active DFGin 6.597 15.228 BLAminus -137.02, 172.06 60.5, 86.03 -101.36, 24.49 279.2, 77.34 -65.25, -31.27 in-in in 8.578 Saltbr-in 3.151 HRD-in -78.61, -60.05 78.55, 19.06 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.89, 166.29 APE9-dihe-na 79.38, 125.96 APE8-dihe-in -52.45, 138.06 APE8-rot-in 299.33 APE67-dihe-in -63.0, -18.82 -55.53, -44.62 APE12-dist-in 13.012 APE11-dist-in 12.27 APE10-dist-in 7.226 APE9-dist-in 3.325 None TPO160 TPO160 XRAY 2.396 0.214 0.216 A 302 298 0 0 0 0 [[4, 286]] 1.0 9esu CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESUC 1 296 298.0 IJU:60301 Type1 Active DFGin 6.756 15.221 BLAminus -141.36, -172.39 47.3, 82.34 -98.62, 30.36 281.12, 66.06 -78.12, -24.78 in-in in 8.502 Saltbr-in 2.861 HRD-in -86.11, -54.93 71.99, 13.31 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.41, 141.48 APE9-dihe-na 77.5, 127.54 APE8-dihe-in -56.29, 139.63 APE8-rot-in 297.98 APE67-dihe-in -53.31, -27.07 -43.94, -55.69 APE12-dist-in 12.83 APE11-dist-in 10.434 APE10-dist-in 7.185 APE9-dist-in 3.27 None TPO160 TPO160 XRAY 2.396 0.214 0.216 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esu CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESXC 1 296 298.0 A1H6Y:60501 Type1 Active DFGin 6.602 15.39 BLAminus -133.13, -177.79 55.96, 73.53 -88.35, 23.36 279.9, 72.69 -58.54, -31.38 in-in in 8.493 Saltbr-in 2.833 HRD-in -85.21, -57.78 75.56, 8.81 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.16, 150.53 APE9-dihe-na 72.07, 129.83 APE8-dihe-in -57.83, 139.49 APE8-rot-in 297.9 APE67-dihe-in -56.08, -27.9 -42.98, -54.66 APE12-dist-in 12.745 APE11-dist-in 10.117 APE10-dist-in 6.852 APE9-dist-in 3.222 None TPO160 TPO160 XRAY 2.37 0.222 0.229 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esx CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESYC 1 296 298.0 HH8:60601 Type1 Active DFGin 6.815 15.392 BLAminus -143.51, -171.61 48.8, 76.72 -98.69, 31.73 280.0, 78.65 -75.94, -27.79 in-in in 8.704 Saltbr-in 2.739 HRD-in -81.36, -63.29 73.99, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.04, 152.88 APE9-dihe-na 70.43, 129.81 APE8-dihe-in -56.88, 139.73 APE8-rot-in 314.35 APE67-dihe-in -55.17, -26.22 -41.74, -56.57 APE12-dist-in 12.652 APE11-dist-in 9.842 APE10-dist-in 6.698 APE9-dist-in 3.152 None TPO160 TPO160 XRAY 2.394 0.257 0.262 C 302 265 31 0 0 0 [[4, 286]] 1.0 9esy CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESZA 1 292 298.0 HGW:60601 Type1 Active DFGin 6.578 15.332 BLAminus -132.04, 171.04 63.6, 85.87 -98.66, 25.0 277.0, 76.47 -70.53, -27.06 in-in in 8.642 Saltbr-in 3.001 HRD-in -80.25, -60.98 81.99, 14.7 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -71.52, 168.74 APE9-dihe-na 75.8, 128.24 APE8-dihe-in -49.62, 139.46 APE8-rot-in 302.85 APE67-dihe-in -59.69, -19.57 -54.76, -48.33 APE12-dist-in 13.123 APE11-dist-in 12.077 APE10-dist-in 7.086 APE9-dist-in 3.248 None TPO160 TPO160 XRAY 2.42 0.212 0.213 A 302 292 0 0 0 0 [[4, 286]] 1.0 9esz CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESZC 1 296 298.0 HGW:60501 Type1 Active DFGin 6.699 15.376 BLAminus -138.8, -176.72 49.7, 80.72 -92.52, 24.31 277.61, 74.75 -64.18, -24.0 in-in in 8.456 Saltbr-in 2.966 HRD-in -81.04, -55.78 70.54, 14.46 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.11, 146.25 APE9-dihe-na 77.04, 123.95 APE8-dihe-in -50.26, 136.24 APE8-rot-in 297.63 APE67-dihe-in -54.0, -25.83 -45.3, -55.89 APE12-dist-in 13.031 APE11-dist-in 10.458 APE10-dist-in 7.148 APE9-dist-in 3.25 None TPO160 TPO160 XRAY 2.42 0.212 0.213 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esz CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET0A 1 298 298.0 HHN:60301 Type1 Active DFGin 6.638 15.241 BLAminus -134.9, 175.1 57.37, 82.81 -94.18, 18.73 280.11, 75.28 -62.18, -27.41 in-in in 8.716 Saltbr-in 3.021 HRD-in -79.22, -60.59 80.44, 14.72 in-in-in SNCiii in-in ActLoopNT-in 2.986 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -60.34, 170.44 APE9-dihe-na 75.62, 129.42 APE8-dihe-in -52.98, 137.89 APE8-rot-in 301.96 APE67-dihe-in -61.35, -20.22 -51.89, -49.35 APE12-dist-in 13.112 APE11-dist-in 11.998 APE10-dist-in 7.119 APE9-dist-in 3.243 None TPO160 TPO160 XRAY 2.239 0.235 0.239 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et0 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET0C 1 296 298.0 HHN:60301 Type1 Active DFGin 6.733 15.638 BLAminus -141.22, -178.98 56.42, 68.49 -82.49, 27.84 282.91, 72.01 -73.64, -20.97 in-in in 8.622 Saltbr-in 2.747 HRD-in -80.75, -59.23 74.38, 11.19 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.37, 152.48 APE9-dihe-na 75.08, 131.84 APE8-dihe-in -56.51, 137.62 APE8-rot-in 304.65 APE67-dihe-in -57.06, -22.75 -41.43, -52.94 APE12-dist-in 12.838 APE11-dist-in 10.435 APE10-dist-in 6.838 APE9-dist-in 3.172 None TPO160 TPO160 XRAY 2.239 0.235 0.239 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et0 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET1C 1 296 298.0 IJL:60301 Type1 Active DFGin 6.623 15.492 BLAminus -135.39, -177.33 51.33, 83.18 -94.5, 20.01 273.11, 76.66 -59.44, -32.33 in-in in 8.593 Saltbr-in 2.876 HRD-in -83.75, -57.91 76.36, 7.46 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.5, 147.34 APE9-dihe-na 76.93, 124.91 APE8-dihe-in -54.11, 139.39 APE8-rot-in 309.88 APE67-dihe-in -59.67, -21.6 -42.38, -52.57 APE12-dist-in 12.846 APE11-dist-in 10.096 APE10-dist-in 7.185 APE9-dist-in 3.216 None TPO160 TPO160 XRAY 2.394 0.221 0.228 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et1 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET2C 1 296 298.0 IJX:60501 Type1 Active DFGin 6.584 15.27 BLAminus -138.1, -174.28 43.8, 86.79 -97.27, 25.78 280.09, 73.01 -64.15, -26.09 in-in in 8.412 Saltbr-in 2.806 HRD-in -80.71, -60.66 80.25, 0.88 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.46, 149.88 APE9-dihe-na 78.61, 126.17 APE8-dihe-in -51.98, 138.05 APE8-rot-in 306.97 APE67-dihe-in -57.75, -25.38 -42.91, -53.12 APE12-dist-in 12.912 APE11-dist-in 10.439 APE10-dist-in 6.89 APE9-dist-in 3.092 None TPO160 TPO160 XRAY 2.37 0.229 0.231 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et2 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET7C 1 296 298.0 HGQ:60301 Type1 Active DFGin 6.628 15.492 BLAminus -134.87, 177.99 57.6, 75.53 -90.81, 23.9 281.22, 72.55 -65.86, -32.54 in-in in 8.641 Saltbr-in 3.015 HRD-in -77.38, -56.31 71.77, 14.03 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.83, 150.81 APE9-dihe-na 73.21, 128.16 APE8-dihe-in -54.48, 138.37 APE8-rot-in 306.51 APE67-dihe-in -58.88, -21.95 -48.81, -49.4 APE12-dist-in 12.875 APE11-dist-in 10.351 APE10-dist-in 7.064 APE9-dist-in 3.362 None TPO160 TPO160 XRAY 2.312 0.241 0.271 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et7 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ETAA 1 298 298.0 7ZX:60601 Type1 Active DFGin 6.843 15.39 BLAminus -130.87, 177.54 61.19, 88.41 -108.49, 29.69 278.15, 78.57 -76.9, -23.03 in-in in 8.704 Saltbr-in 3.381 HRD-in -80.89, -60.33 80.32, 14.58 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.1, 157.98 APE9-dihe-na 80.83, 121.24 APE8-dihe-in -46.09, 138.61 APE8-rot-in 304.51 APE67-dihe-in -61.54, -19.39 -60.41, -43.93 APE12-dist-in 13.081 APE11-dist-in 11.907 APE10-dist-in 7.224 APE9-dist-in 3.18 None TPO160 TPO160 XRAY 2.512 0.22 0.24 A 302 298 0 0 0 0 [[4, 286]] 1.0 9eta CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ETAC 1 296 298.0 7ZX:60301 Type1 Active DFGin 6.608 15.586 BLAminus -137.08, 177.84 55.91, 77.1 -88.51, 26.15 277.04, 73.55 -60.47, -35.41 in-in in 8.739 Saltbr-in 2.914 HRD-in -81.68, -51.59 67.1, 13.15 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.15, 148.64 APE9-dihe-na 70.71, 128.57 APE8-dihe-in -53.3, 142.24 APE8-rot-in 310.82 APE67-dihe-in -59.33, -28.84 -51.21, -47.8 APE12-dist-in 13.08 APE11-dist-in 10.731 APE10-dist-in 7.013 APE9-dist-in 3.3 None TPO160 TPO160 XRAY 2.512 0.22 0.24 C 302 296 0 0 0 0 [[4, 286]] 1.0 9eta CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H1PA 1 296 298.0 CMG:61298 Type1 Active DFGin 6.499 15.117 BLAminus -138.92, -178.75 49.09, 86.95 -98.56, 13.99 278.53, 73.35 -55.78, -28.79 in-in in 8.454 Saltbr-in 2.721 HRD-in -77.48, -54.23 72.33, 13.84 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.77, 156.24 APE9-dihe-na 69.07, 128.03 APE8-dihe-in -49.71, 132.1 APE8-rot-in 291.9 APE67-dihe-in -61.95, -27.18 -48.08, -36.47 APE12-dist-in 13.052 APE11-dist-in 10.052 APE10-dist-in 7.235 APE9-dist-in 3.162 None TPO160 TPO160 XRAY 2.1 0.222 0.258 A 303 296 0 0 0 0 [[4, 286]] 1.0 1h1p CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H1PC 1 296 298.0 CMG:61298 Type1 Active DFGin 6.566 15.153 BLAminus -139.68, 176.89 52.0, 85.54 -98.31, 22.42 285.04, 73.37 -70.33, -22.32 in-in in 8.589 Saltbr-in 2.781 HRD-in -79.75, -57.12 71.34, 16.79 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.98, 156.69 APE9-dihe-na 68.49, 129.02 APE8-dihe-in -58.75, 132.04 APE8-rot-in 288.32 APE67-dihe-in -70.71, -22.16 -48.03, -37.61 APE12-dist-in 12.877 APE11-dist-in 9.888 APE10-dist-in 7.254 APE9-dist-in 3.241 None TPO160 TPO160 XRAY 2.1 0.222 0.258 C 303 296 0 0 0 0 [[4, 286]] 1.0 1h1p CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H1QC 1 296 298.0 2A6:61298 Type1 Active DFGin 6.238 14.7 BLAminus -137.56, 168.0 63.76, 81.0 -88.76, 14.52 280.77, 71.51 -57.63, -25.21 in-in in 8.403 Saltbr-in 2.986 HRD-in -87.0, -45.2 67.54, 31.89 in-in-in SNCiii in-in ActLoopNT-in 2.778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.07, 157.24 APE9-dihe-na 53.6, 133.67 APE8-dihe-in -53.3, 139.53 APE8-rot-in 282.96 APE67-dihe-in -62.62, -13.03 -52.36, -46.94 APE12-dist-in 12.909 APE11-dist-in 10.223 APE10-dist-in 7.579 APE9-dist-in 3.209 None TPO160 TPO160 XRAY 2.5 0.238 0.332 C 303 296 0 0 0 0 [[4, 286]] 1.0 1h1q CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H1RA 1 296 298.0 6CP:61298 Type1 Active DFGin 6.778 15.045 BLAminus -141.23, 176.27 52.5, 80.35 -92.59, 20.98 276.21, 73.58 -61.73, -20.62 in-in in 8.611 Saltbr-in 2.618 HRD-in -81.53, -52.36 73.7, 8.7 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.38, 147.29 APE9-dihe-na 77.95, 127.28 APE8-dihe-in -54.9, 142.91 APE8-rot-in 298.86 APE67-dihe-in -65.2, -19.39 -52.85, -42.63 APE12-dist-in 13.037 APE11-dist-in 10.006 APE10-dist-in 7.64 APE9-dist-in 3.218 None TPO160 TPO160 XRAY 2.0 0.235 0.294 A 303 296 0 0 0 0 [[4, 286]] 1.0 1h1r CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H1RC 1 296 298.0 6CP:61298 Type1 Active DFGin 6.553 14.842 BLAminus -148.02, -175.89 41.5, 81.22 -90.01, 20.08 282.78, 67.07 -58.8, -29.6 in-in in 8.628 Saltbr-in 2.435 HRD-in -79.05, -61.01 72.22, 16.79 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.3, 151.09 APE9-dihe-na 62.76, 123.0 APE8-dihe-in -43.65, 134.07 APE8-rot-in 300.23 APE67-dihe-in -54.33, -21.74 -47.48, -55.72 APE12-dist-in 12.822 APE11-dist-in 9.742 APE10-dist-in 7.312 APE9-dist-in 3.321 None TPO160 TPO160 XRAY 2.0 0.235 0.294 C 303 296 0 0 0 0 [[4, 286]] 1.0 1h1r CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H1SA 1 296 298.0 4SP:61298 Type1 Active DFGin 6.771 14.88 BLAminus -138.27, 176.48 54.47, 75.94 -86.39, 16.38 279.91, 75.66 -60.96, -21.57 in-in in 8.523 Saltbr-in 2.546 HRD-in -82.14, -48.27 62.29, 17.28 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.1, 148.9 APE9-dihe-na 77.73, 132.64 APE8-dihe-in -56.46, 146.46 APE8-rot-in 297.88 APE67-dihe-in -62.68, -22.66 -55.95, -45.74 APE12-dist-in 13.041 APE11-dist-in 10.252 APE10-dist-in 7.488 APE9-dist-in 3.216 None TPO160 TPO160 XRAY 2.0 0.236 0.286 A 303 296 0 0 0 0 [[4, 286]] 1.0 1h1s CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H1SC 1 296 298.0 4SP:61298 Type1 Active DFGin 6.574 15.065 BLAminus -139.76, -179.38 46.77, 76.48 -88.51, 14.99 275.39, 74.13 -49.48, -23.18 in-in in 8.909 Saltbr-in 2.634 HRD-in -75.61, -51.23 64.22, 19.85 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.84, 146.42 APE9-dihe-na 78.4, 136.91 APE8-dihe-in -69.97, 138.51 APE8-rot-in 287.12 APE67-dihe-in -55.51, -31.94 -44.12, -51.67 APE12-dist-in 13.078 APE11-dist-in 10.307 APE10-dist-in 7.331 APE9-dist-in 3.176 None TPO160 TPO160 XRAY 2.0 0.236 0.286 C 303 296 0 0 0 0 [[4, 286]] 1.0 1h1s CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFMA 1 296 298.0 4QE:61297 Type1 Active DFGin 6.388 15.294 BLAminus -138.86, -176.13 51.5, 75.94 -84.71, 19.18 282.42, 65.54 -49.76, -36.4 in-in in 8.548 Saltbr-in 2.661 HRD-in -81.16, -48.5 61.38, 12.94 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.25, 140.44 APE9-dihe-na 73.77, 137.41 APE8-dihe-in -62.76, 142.45 APE8-rot-in 324.66 APE67-dihe-in -57.36, -23.49 -43.84, -57.99 APE12-dist-in 12.853 APE11-dist-in 10.405 APE10-dist-in 7.512 APE9-dist-in 3.169 None TPO160 TPO160 XRAY 2.85 0.219 0.258 A 303 296 0 0 0 0 [[4, 286]] 1.0 4cfm CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFMC 1 296 298.0 4QE:61297 Type1 Active DFGin 6.221 15.189 BLAminus -142.93, -178.85 51.13, 76.15 -84.23, 19.76 283.72, 70.42 -51.95, -31.37 in-in in 8.353 Saltbr-in 2.625 HRD-in -79.93, -49.37 65.61, 16.12 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.92, 141.62 APE9-dihe-na 71.18, 140.32 APE8-dihe-in -65.45, 140.0 APE8-rot-in 314.14 APE67-dihe-in -54.47, -25.31 -33.87, -64.74 APE12-dist-in 12.864 APE11-dist-in 10.339 APE10-dist-in 7.301 APE9-dist-in 3.206 None TPO160 TPO160 XRAY 2.85 0.219 0.258 C 303 266 30 0 0 0 [[4, 286]] 1.0 4cfm CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFWA 1 298 298.0 SQ9:61299 Type1 Active DFGin 6.75 15.485 BLAminus -136.96, -173.97 45.59, 77.09 -83.58, 21.25 281.72, 72.41 -61.45, -31.18 in-in in 8.97 Saltbr-in 2.774 HRD-in -80.37, -54.45 72.08, 16.81 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.22, 147.94 APE9-dihe-na 77.59, 131.51 APE8-dihe-in -59.06, 146.89 APE8-rot-in 296.38 APE67-dihe-in -59.52, -23.68 -54.1, -46.67 APE12-dist-in 13.008 APE11-dist-in 10.199 APE10-dist-in 7.122 APE9-dist-in 3.321 None TPO160 TPO160 XRAY 2.45 0.188 0.241 A 303 298 0 0 0 0 [[4, 286]] 1.0 4cfw CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFWC 1 296 298.0 SQ9:61297 Type1 Active DFGin 6.736 15.424 BLAminus -141.99, -176.48 44.07, 78.18 -86.53, 15.76 283.21, 70.66 -50.68, -33.08 in-in in 8.919 Saltbr-in 2.804 HRD-in -80.65, -49.07 61.58, 17.73 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.23, 149.27 APE9-dihe-na 77.75, 130.41 APE8-dihe-in -57.97, 143.53 APE8-rot-in 298.16 APE67-dihe-in -59.74, -25.8 -48.23, -50.27 APE12-dist-in 13.098 APE11-dist-in 10.272 APE10-dist-in 7.093 APE9-dist-in 3.314 None TPO160 TPO160 XRAY 2.45 0.188 0.241 C 303 296 0 0 0 0 [[4, 286]] 1.0 4cfw CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFXA 1 298 298.0 G6T:61299 Type1 Active DFGin 6.601 15.153 BLAminus -137.97, 169.05 56.34, 77.85 -94.42, 27.07 283.56, 72.41 -55.94, -34.34 in-in in 8.739 Saltbr-in 3.413 HRD-in -80.0, -48.77 67.93, 12.9 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.93, 133.26 APE9-dihe-na -134.31, -168.88 APE8-dihe-in -52.68, 136.23 APE8-rot-in 289.49 APE67-dihe-in -51.99, -24.9 -51.69, -52.0 APE12-dist-in 13.144 APE11-dist-in 10.601 APE10-dist-in 7.605 APE9-dist-in 3.485 None TPO160 TPO160 XRAY 3.5 0.207 0.269 A 303 298 0 0 0 0 [[4, 286]] 1.0 4cfx CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFXC 1 298 298.0 G6T:61299 Type1 Active DFGin 6.754 15.157 BLAminus -142.34, 170.11 55.48, 71.6 -85.7, 23.38 285.39, 68.53 -51.58, -29.63 in-in in 8.846 Saltbr-in 2.538 HRD-in -79.55, -56.78 72.59, 13.73 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.79, 170.79 APE9-dihe-na 64.39, -170.45 APE8-dihe-in -117.6, 151.27 APE8-rot-in 271.11 APE67-dihe-in -61.81, -23.06 -60.79, -44.0 APE12-dist-in 12.996 APE11-dist-in 10.555 APE10-dist-in 7.357 APE9-dist-in 3.111 None TPO160 TPO160 XRAY 3.5 0.207 0.269 C 303 298 0 0 0 0 [[4, 286]] 1.0 4cfx CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5CYIA 1 298 298.0 55S:60301 Type1 Active DFGin 6.767 14.97 BLAminus -137.64, 176.63 47.15, 80.48 -91.39, 21.66 281.55, 70.58 -67.03, -18.55 in-in in 8.62 Saltbr-in 2.688 HRD-in -78.06, -52.75 68.08, 20.4 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.3, 140.21 APE9-dihe-na 78.36, 138.66 APE8-dihe-in -62.96, 141.91 APE8-rot-in 296.28 APE67-dihe-in -57.57, -24.32 -47.6, -52.43 APE12-dist-in 13.034 APE11-dist-in 10.317 APE10-dist-in 7.494 APE9-dist-in 3.236 None TPO160 TPO160 XRAY 2.0 0.228 0.255 A 303 298 0 0 0 0 [[4, 286]] 1.0 5cyi CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5CYIC 1 296 298.0 55S:60301 Type1 Active DFGin 6.739 14.921 BLAminus -137.77, 174.67 47.68, 81.07 -90.89, 22.34 281.65, 70.16 -66.05, -19.77 in-in in 8.583 Saltbr-in 2.693 HRD-in -76.15, -53.07 68.94, 20.52 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.13, 139.64 APE9-dihe-na 76.95, 137.97 APE8-dihe-in -61.9, 140.82 APE8-rot-in 297.24 APE67-dihe-in -53.17, -25.9 -44.59, -55.44 APE12-dist-in 12.993 APE11-dist-in 10.338 APE10-dist-in 7.436 APE9-dist-in 3.216 None TPO160 TPO160 XRAY 2.0 0.228 0.255 C 303 296 0 0 0 0 [[4, 286]] 1.0 5cyi CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7MKXC 1 296 298.0 ZGY:60301 Type1 Active DFGin 6.277 15.114 BLAminus -140.36, 171.89 55.66, 70.68 -84.32, 23.75 280.3, 66.0 -61.29, -36.7 in-in in 8.541 Saltbr-in 3.198 HRD-in -78.5, -56.26 72.21, 7.67 in-in-in SNCiii in-in ActLoopNT-in 2.774 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.45, 89.97 APE9-dihe-na -178.93, 147.76 APE8-dihe-in -57.48, 133.34 APE8-rot-in 301.11 APE67-dihe-in -60.92, -21.4 -53.06, -47.27 APE12-dist-in 12.957 APE11-dist-in 11.013 APE10-dist-in 6.455 APE9-dist-in 3.741 None TPO160 TPO160 XRAY 3.08 0.248 0.289 C 303 296 0 0 0 0 [[4, 286]] 1.0 7mkx CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFUA 1 298 298.0 2WC:61299 Type1 Active DFGin 6.634 15.251 BLAminus -143.94, -176.45 46.96, 77.88 -92.02, 16.12 280.08, 76.99 -62.89, -22.81 in-in in 8.713 Saltbr-in 2.975 HRD-in -80.47, -54.45 73.66, 15.81 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.95, 168.09 APE9-dihe-na 80.99, 130.01 APE8-dihe-in -53.93, 138.04 APE8-rot-in 303.21 APE67-dihe-in -61.6, -22.53 -50.67, -47.86 APE12-dist-in 13.05 APE11-dist-in 9.288 APE10-dist-in 7.192 APE9-dist-in 3.199 None TPO160 TPO160 XRAY 2.2 0.184 0.221 A 303 296 2 0 0 0 [[4, 286]] 1.0 4cfu CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFUC 1 296 298.0 2WC:61297 Type1 Active DFGin 6.577 15.28 BLAminus -141.53, -176.08 45.07, 77.67 -88.55, 18.31 280.58, 72.89 -62.8, -25.25 in-in in 8.673 Saltbr-in 2.72 HRD-in -78.69, -56.62 72.36, 16.74 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.7, 153.81 APE9-dihe-na 73.42, 126.58 APE8-dihe-in -58.01, 141.67 APE8-rot-in 299.68 APE67-dihe-in -60.97, -24.17 -47.05, -49.4 APE12-dist-in 12.745 APE11-dist-in 10.039 APE10-dist-in 6.807 APE9-dist-in 3.208 None TPO160 TPO160 XRAY 2.2 0.184 0.221 C 303 270 26 0 0 0 [[4, 286]] 1.0 4cfu CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFVA 1 298 298.0 75X:61299 Type1 Active DFGin 6.645 15.346 BLAminus -137.55, 177.58 52.88, 79.8 -90.24, 13.9 279.4, 75.16 -62.7, -24.78 in-in in 8.815 Saltbr-in 2.538 HRD-in -78.24, -53.69 69.33, 13.55 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.05, 169.07 APE9-dihe-na 75.09, 131.62 APE8-dihe-in -56.21, 139.88 APE8-rot-in 298.93 APE67-dihe-in -57.83, -24.18 -48.22, -53.05 APE12-dist-in 13.152 APE11-dist-in 9.349 APE10-dist-in 7.225 APE9-dist-in 3.189 None TPO160 TPO160 XRAY 2.0 0.18 0.205 A 303 298 0 0 0 0 [[4, 286]] 1.0 4cfv CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4CFVC 1 296 298.0 75X:61297 Type1 Active DFGin 6.614 15.334 BLAminus -134.83, -178.5 49.4, 77.95 -89.89, 17.93 278.23, 73.7 -62.88, -26.68 in-in in 8.728 Saltbr-in 3.002 HRD-in -76.67, -55.73 68.34, 12.47 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.17, 150.42 APE9-dihe-na 70.74, 131.03 APE8-dihe-in -55.87, 141.77 APE8-rot-in 303.94 APE67-dihe-in -61.42, -22.75 -47.9, -49.95 APE12-dist-in 12.739 APE11-dist-in 10.096 APE10-dist-in 6.989 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.0 0.18 0.205 C 303 264 32 0 0 0 [[4, 286]] 1.0 4cfv CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1VYWC 1 298 298.0 292:62300 Type1 Active DFGin 6.523 15.767 BLAminus -146.25, 178.96 56.14, 83.81 -105.77, 25.65 281.9, 67.54 -64.15, -29.51 in-in in 8.953 Saltbr-in 3.212 HRD-in -73.63, -51.91 70.52, -1.97 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.65, -86.84 APE9-dihe-na -54.67, 131.52 APE8-dihe-in -46.41, 133.51 APE8-rot-in 308.89 APE67-dihe-in -56.19, -27.67 -42.04, -52.59 APE12-dist-in 13.579 APE11-dist-in 12.392 APE10-dist-in 7.698 APE9-dist-in 3.701 None None None XRAY 2.3 0.229 0.258 C 309 298 0 0 0 0 [[4, 286]] 1.0 1vyw CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2BKZA 1 298 298.0 SBC:61299 Type1 Active DFGin 6.28 15.23 BLAminus -142.78, 175.8 58.31, 77.96 -96.55, 27.58 284.6, 62.36 -62.3, -30.15 in-in in 8.582 Saltbr-in 2.806 HRD-in -73.7, -53.54 71.63, -3.26 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.33, -29.51 APE9-dihe-na -59.32, 128.75 APE8-dihe-in -48.05, 131.7 APE8-rot-in 304.88 APE67-dihe-in -54.69, -27.7 -44.06, -56.71 APE12-dist-in 13.532 APE11-dist-in 12.023 APE10-dist-in 6.738 APE9-dist-in 3.734 None None None XRAY 2.6 0.23 0.259 A 309 298 0 0 0 0 [[4, 286]] 1.0 2bkz CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2BKZC 1 297 298.0 SBC:61298 Type1 Active DFGin 6.315 15.267 BLAminus -143.86, 175.39 58.38, 79.09 -98.11, 27.24 283.82, 63.13 -62.03, -28.81 in-in in 8.57 Saltbr-in 2.766 HRD-in -73.89, -52.71 71.33, -3.06 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.29, -29.31 APE9-dihe-na -58.91, 127.76 APE8-dihe-in -47.57, 131.64 APE8-rot-in 304.51 APE67-dihe-in -54.25, -28.48 -45.04, -55.47 APE12-dist-in 13.525 APE11-dist-in 12.026 APE10-dist-in 6.736 APE9-dist-in 3.729 None None None XRAY 2.6 0.23 0.259 C 309 297 0 0 0 0 [[4, 286]] 1.0 2bkz CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2BPMC 1 298 298.0 529:61299 Type1 Active DFGin 6.476 15.691 BLAminus -139.11, -176.99 50.31, 82.01 -98.98, 24.72 279.58, 68.95 -62.44, -20.88 in-in in 8.975 Saltbr-in 3.405 HRD-in -80.64, -57.02 72.88, 2.66 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.51, -77.27 APE9-dihe-na -63.86, 135.95 APE8-dihe-in -52.79, 132.77 APE8-rot-in 309.35 APE67-dihe-in -57.16, -24.3 -34.82, -55.34 APE12-dist-in 13.242 APE11-dist-in 11.949 APE10-dist-in 7.171 APE9-dist-in 3.521 None None None XRAY 2.4 0.229 0.271 C 309 298 0 0 0 0 [[4, 286]] 1.0 2bpm CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C4GC 1 298 298.0 514:60306 Type1 Active DFGin 6.367 15.719 BLAminus -139.83, -179.8 56.9, 82.39 -100.75, 22.8 279.84, 72.16 -55.14, -30.61 in-in in 9.107 Saltbr-in 3.525 HRD-in -76.45, -47.57 65.3, 7.78 in-in-in SNCiii in-in ActLoopNT-in 2.765 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.95, -47.05 APE9-dihe-na -79.06, 130.37 APE8-dihe-in -53.02, 141.81 APE8-rot-in 298.24 APE67-dihe-in -53.93, -25.26 -49.41, -57.46 APE12-dist-in 13.735 APE11-dist-in 11.863 APE10-dist-in 6.729 APE9-dist-in 3.743 None None None XRAY 2.7 0.233 0.25 C 309 298 0 0 0 0 [[4, 286]] 1.0 2c4g CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WIHC 1 298 298.0 P48:61299 Type1 Active DFGin 6.515 15.502 BLAminus -139.53, 171.28 64.6, 87.79 -105.04, 25.11 279.58, 71.52 -58.59, -37.4 in-in in 8.856 Saltbr-in 2.9 HRD-in -79.72, -52.5 76.18, -5.97 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.83, -70.3 APE9-dihe-na -57.72, 136.41 APE8-dihe-in -51.89, 139.14 APE8-rot-in 308.59 APE67-dihe-in -63.31, -27.96 -57.76, -40.98 APE12-dist-in 13.362 APE11-dist-in 12.02 APE10-dist-in 7.022 APE9-dist-in 3.642 None None None XRAY 2.5 0.215 0.25 C 309 298 0 0 0 0 [[4, 286]] 1.0 2wih CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WPAC 1 298 298.0 889:61300 Type1 Active DFGin 6.557 15.668 BLAminus -144.77, 174.3 58.47, 90.93 -109.08, 19.58 277.99, 68.6 -59.79, -26.46 in-in in 9.033 Saltbr-in 2.675 HRD-in -78.48, -54.37 78.2, -2.73 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.71, -53.13 APE9-dihe-na -78.14, 130.12 APE8-dihe-in -48.02, 138.87 APE8-rot-in 297.69 APE67-dihe-in -59.43, -34.95 -58.75, -45.0 APE12-dist-in 13.596 APE11-dist-in 11.656 APE10-dist-in 6.669 APE9-dist-in 3.482 None None None XRAY 2.51 0.223 0.261 C 309 298 0 0 0 0 [[4, 286]] 1.0 2wpa CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6GUEA 1 298 298.0 FB8:60301 Type1 Active DFGin 6.754 15.496 BLAminus -136.13, 174.07 55.03, 81.74 -90.85, 16.49 281.66, 71.64 -57.24, -30.62 in-in in 8.788 Saltbr-in 2.403 HRD-in -77.82, -55.96 73.4, 10.98 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.32, 165.89 APE9-dihe-na 84.86, 131.41 APE8-dihe-in -49.42, 131.75 APE8-rot-in 295.4 APE67-dihe-in -60.88, -20.37 -49.88, -45.18 APE12-dist-in 13.336 APE11-dist-in 12.57 APE10-dist-in 7.556 APE9-dist-in 3.205 None TPO160 TPO160 XRAY 1.99 0.198 0.234 A 302 293 5 0 0 0 [[4, 286]] 1.0 6gue CMGC_CDK2_HUMAN CMGC 6.9e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2IW8A 1 297 298.0 4SP:61298 Type1 Active DFGin 6.907 14.876 BLAminus -128.94, 178.15 45.79, 77.82 -89.54, 20.73 278.33, 75.94 -62.77, -23.59 in-in in 8.52 Saltbr-in 2.678 HRD-in -82.44, -53.34 71.08, 17.45 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.18, 148.54 APE9-dihe-na 67.67, 128.23 APE8-dihe-in -55.32, 132.5 APE8-rot-in 304.46 APE67-dihe-in -56.59, -27.86 -44.81, -49.42 APE12-dist-in 12.947 APE11-dist-in 10.439 APE10-dist-in 7.316 APE9-dist-in 3.253 F82H,L83V,H84D TPO160 TPO160 XRAY 2.3 0.214 0.255 A 302 297 0 0 0 0 [[4, 286]] 1.0 2iw8 CMGC_CDK2_HUMAN CMGC 1.1e-89 307.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2IW8C 1 296 298.0 4SP:61297 Type1 Active DFGin 6.776 14.993 BLAminus -119.11, -171.67 36.55, 74.77 -80.97, 23.02 280.6, 75.2 -62.4, -19.17 in-in in 8.672 Saltbr-in 2.482 HRD-in -81.37, -52.61 71.76, 20.77 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.18, 153.02 APE9-dihe-na 61.13, 127.0 APE8-dihe-in -47.11, 147.78 APE8-rot-in 315.45 APE67-dihe-in -43.58, -23.45 -49.47, -61.15 APE12-dist-in 12.906 APE11-dist-in 9.942 APE10-dist-in 7.204 APE9-dist-in 3.417 F82H,L83V,H84D TPO160 TPO160 XRAY 2.3 0.214 0.255 C 302 265 31 0 0 0 [[4, 286]] 1.0 2iw8 CMGC_CDK2_HUMAN CMGC 1.1e-89 307.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESKC 1 296 298.0 W3D:60501,W3D:60502 Type1,Allosteric Active DFGin 6.638 15.284 BLAminus -137.51, -173.46 49.66, 73.42 -88.73, 25.05 278.15, 71.06 -63.4, -24.24 in-in in 8.507 Saltbr-in 2.776 HRD-in -81.97, -57.15 70.97, 10.51 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.08, 143.45 APE9-dihe-na 79.68, 124.98 APE8-dihe-in -55.57, 144.7 APE8-rot-in 305.12 APE67-dihe-in -55.94, -29.23 -48.29, -54.73 APE12-dist-in 12.79 APE11-dist-in 10.221 APE10-dist-in 6.996 APE9-dist-in 3.215 None TPO160 TPO160 XRAY 2.398 0.211 0.217 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esk CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESLC 1 296 298.0 V3U:60301,V3U:60302 Type1,Allosteric Active DFGin 6.673 15.405 BLAminus -140.55, -177.95 50.02, 80.84 -92.78, 20.52 278.3, 72.54 -61.36, -26.37 in-in in 8.635 Saltbr-in 2.812 HRD-in -80.59, -57.08 73.08, 12.06 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.86, 147.72 APE9-dihe-na 75.57, 125.72 APE8-dihe-in -53.85, 140.25 APE8-rot-in 308.57 APE67-dihe-in -54.82, -27.93 -44.39, -53.4 APE12-dist-in 12.718 APE11-dist-in 10.064 APE10-dist-in 6.858 APE9-dist-in 3.263 None TPO160 TPO160 XRAY 2.392 0.217 0.22 C 302 268 28 0 0 0 [[4, 286]] 1.0 9esl CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESNC 1 296 298.0 UUS:60501,UUS:60502 Type1,Allosteric Active DFGin 6.783 15.35 BLAminus -134.32, -173.37 48.7, 77.83 -95.39, 23.82 280.48, 71.42 -70.86, -18.35 in-in in 8.469 Saltbr-in 2.858 HRD-in -86.45, -56.57 72.38, 12.62 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.86, 146.56 APE9-dihe-na 76.71, 123.38 APE8-dihe-in -49.22, 142.2 APE8-rot-in 311.1 APE67-dihe-in -53.84, -27.08 -45.75, -55.53 APE12-dist-in 12.859 APE11-dist-in 10.419 APE10-dist-in 6.951 APE9-dist-in 3.287 None TPO160 TPO160 XRAY 2.393 0.209 0.213 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esn CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESRC 1 296 298.0 UU1:60501,UU1:60502 Type1,Allosteric Active DFGin 6.652 15.072 BLAminus -145.73, -177.82 46.05, 80.55 -92.88, 23.57 287.5, 67.77 -53.91, -33.17 in-in in 8.317 Saltbr-in 2.701 HRD-in -84.72, -55.44 71.68, 6.95 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.21, 146.03 APE9-dihe-na 73.67, 122.79 APE8-dihe-in -45.48, 138.32 APE8-rot-in 312.39 APE67-dihe-in -52.0, -25.98 -45.15, -57.7 APE12-dist-in 12.99 APE11-dist-in 10.131 APE10-dist-in 7.114 APE9-dist-in 3.175 None TPO160 TPO160 XRAY 2.388 0.221 0.227 C 302 266 30 0 0 0 [[4, 286]] 1.0 9esr CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESSC 1 296 298.0 UUG:60501,UUG:60502 Type1,Allosteric Active DFGin 6.631 14.933 BLAminus -142.84, 175.97 51.2, 79.73 -89.56, 21.72 284.95, 67.51 -58.42, -34.37 in-in in 8.295 Saltbr-in 2.868 HRD-in -75.14, -63.05 75.45, 9.68 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.9, 146.77 APE9-dihe-na 74.13, 121.78 APE8-dihe-in -44.27, 147.71 APE8-rot-in 310.11 APE67-dihe-in -53.57, -23.24 -51.44, -55.49 APE12-dist-in 12.636 APE11-dist-in 9.974 APE10-dist-in 6.855 APE9-dist-in 3.245 None TPO160 TPO160 XRAY 2.44 0.212 0.219 C 302 265 31 0 0 0 [[4, 286]] 1.0 9ess CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESVC 1 295 298.0 3Z7:60501,3Z7:60502 Type1,Allosteric Active DFGin 6.768 15.236 BLAminus -139.75, 176.56 54.81, 81.21 -90.94, 16.67 278.85, 71.78 -56.97, -37.98 in-in in 8.453 Saltbr-in 2.882 HRD-in -80.1, -61.08 77.4, 12.62 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.79, 159.88 APE9-dihe-na 80.45, 128.43 APE8-dihe-in -53.65, 150.6 APE8-rot-in 315.25 APE67-dihe-in -53.52, -24.6 -48.05, -59.38 APE12-dist-in 12.614 APE11-dist-in 11.366 APE10-dist-in 6.641 APE9-dist-in 3.219 None TPO160 TPO160 XRAY 2.397 0.227 0.229 C 302 264 31 0 0 0 [[4, 286]] 1.0 9esv CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESXA 1 290 298.0 A1H6Y:60601,A1H6Y:60602 Type1,Allosteric Active DFGin 6.653 15.338 BLAminus -144.59, 175.62 57.61, 83.73 -105.01, 35.81 281.7, 71.92 -82.28, -22.63 in-in in 8.596 Saltbr-in 2.992 HRD-in -81.07, -59.53 79.35, 13.94 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.52, 145.33 APE9-dihe-na 77.45, 118.76 APE8-dihe-in -49.06, 129.75 APE8-rot-in 301.07 APE67-dihe-in -59.92, -20.73 -43.74, -50.25 APE12-dist-in 12.802 APE11-dist-in 9.82 APE10-dist-in 7.12 APE9-dist-in 3.283 None TPO160 TPO160 XRAY 2.37 0.222 0.229 A 302 290 0 0 0 0 [[4, 286]] 1.0 9esx CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET4A 1 292 298.0 A1H6X:60601,A1H6X:60603 Type1,Allosteric Active DFGin 6.633 15.549 BLAminus -134.84, 172.65 61.14, 83.32 -99.32, 22.95 280.23, 75.12 -63.71, -31.1 in-in in 8.693 Saltbr-in 3.125 HRD-in -81.89, -57.78 79.18, 16.7 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.49, 161.44 APE9-dihe-na 79.45, 129.92 APE8-dihe-in -54.31, 127.59 APE8-rot-in 279.58 APE67-dihe-in -56.0, -21.82 -38.83, -54.37 APE12-dist-in 13.033 APE11-dist-in 12.229 APE10-dist-in 7.259 APE9-dist-in 3.405 None TPO160 TPO160 XRAY 2.641 0.22 0.222 A 302 289 3 0 0 0 [[4, 286]] 1.0 9et4 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET4C 1 294 298.0 A1H6X:60501,A1H6X:60502 Type1,Allosteric Active DFGin 6.649 15.437 BLAminus -135.93, -174.31 48.97, 78.73 -88.03, 26.85 282.26, 61.74 -61.22, -38.83 in-in in 8.613 Saltbr-in 2.78 HRD-in -94.76, -49.17 61.89, 17.84 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.87, 147.92 APE9-dihe-na 79.68, 125.87 APE8-dihe-in -54.62, 145.03 APE8-rot-in 295.75 APE67-dihe-in -55.12, -26.19 -51.19, -50.76 APE12-dist-in 12.808 APE11-dist-in 10.219 APE10-dist-in 6.955 APE9-dist-in 3.301 None TPO160 TPO160 XRAY 2.641 0.22 0.222 C 302 294 0 0 0 0 [[4, 286]] 1.0 9et4 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET5A 1 294 298.0 T5G:60501,T5G:60503 Type1,Allosteric Active DFGin 6.678 15.291 BLAminus -137.17, 178.34 60.51, 85.6 -108.17, 31.01 281.27, 78.69 -80.57, -23.43 in-in in 8.726 Saltbr-in 2.905 HRD-in -80.11, -56.4 77.63, 19.45 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.95, 140.76 APE9-dihe-na 77.59, 129.77 APE8-dihe-in -58.29, 133.79 APE8-rot-in 288.36 APE67-dihe-in -61.58, -15.9 -39.95, -50.82 APE12-dist-in 12.774 APE11-dist-in 9.662 APE10-dist-in 7.134 APE9-dist-in 3.396 None TPO160 TPO160 XRAY 2.53 0.201 0.221 A 302 294 0 0 0 0 [[4, 286]] 1.0 9et5 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET5C 1 296 298.0 T5G:60501,T5G:60502 Type1,Allosteric Active DFGin 6.662 15.494 BLAminus -134.15, -179.13 56.52, 75.78 -94.35, 30.58 280.05, 68.52 -72.1, -25.78 in-in in 8.742 Saltbr-in 2.669 HRD-in -82.99, -55.97 71.28, 11.54 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.03, 145.44 APE9-dihe-na 80.72, 131.2 APE8-dihe-in -58.76, 142.02 APE8-rot-in 303.79 APE67-dihe-in -55.68, -24.95 -43.97, -53.66 APE12-dist-in 12.765 APE11-dist-in 10.549 APE10-dist-in 6.832 APE9-dist-in 3.271 None TPO160 TPO160 XRAY 2.53 0.201 0.221 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et5 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET7A 1 289 298.0 HGQ:60301,HGQ:60302 Type1,Allosteric Active DFGin 6.684 15.297 BLAminus -134.16, 175.42 60.98, 76.23 -92.01, 22.87 281.63, 72.75 -65.33, -31.28 in-in in 8.681 Saltbr-in 2.981 HRD-in -77.49, -57.6 73.35, 16.1 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.54, 163.96 APE9-dihe-na 75.76, 128.99 APE8-dihe-in -52.61, 137.53 APE8-rot-in 306.37 APE67-dihe-in -58.89, -21.47 -51.05, -48.57 APE12-dist-in 13.218 APE11-dist-in 11.88 APE10-dist-in 7.023 APE9-dist-in 3.295 None TPO160 TPO160 XRAY 2.312 0.241 0.271 A 302 289 0 0 0 0 [[4, 286]] 1.0 9et7 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET9C 1 296 298.0 HEW:60701,HEW:60702 Type1,Allosteric Active DFGin 6.777 15.342 BLAminus -145.5, -178.18 52.74, 79.01 -102.36, 32.74 279.23, 71.65 -77.89, -27.55 in-in in 8.53 Saltbr-in 3.195 HRD-in -81.68, -55.92 73.5, 13.51 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.61, 143.17 APE9-dihe-na 75.3, 125.76 APE8-dihe-in -51.4, 141.63 APE8-rot-in 308.72 APE67-dihe-in -57.1, -22.45 -43.98, -53.09 APE12-dist-in 12.701 APE11-dist-in 9.99 APE10-dist-in 7.15 APE9-dist-in 3.279 None TPO160 TPO160 XRAY 2.494 0.225 0.246 C 302 286 10 0 0 0 [[4, 286]] 1.0 9et9 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESJC 1 296 298.0 HHT:60501,HHT:60502,HHT:60503 Type1,Allosteric,Allosteric Active DFGin 6.615 15.221 BLAminus -137.79, -171.11 40.67, 80.8 -88.42, 26.95 282.0, 68.25 -67.86, -17.18 in-in in 8.634 Saltbr-in 2.934 HRD-in -82.8, -62.24 79.8, 7.77 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.91, 149.4 APE9-dihe-na 72.98, 130.17 APE8-dihe-in -58.17, 146.1 APE8-rot-in 299.44 APE67-dihe-in -57.51, -23.31 -50.67, -52.77 APE12-dist-in 12.625 APE11-dist-in 9.906 APE10-dist-in 6.704 APE9-dist-in 3.201 None TPO160 TPO160 XRAY 2.37 0.218 0.223 C 302 269 27 0 0 0 [[4, 286]] 1.0 9esj CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESKA 1 298 298.0 W3D:60601,W3D:60602,W3D:60603 Type1,Allosteric,Allosteric Active DFGin 6.761 15.251 BLAminus -134.47, 176.96 63.67, 79.26 -100.81, 21.22 280.31, 65.37 -78.45, -3.37 in-in in 8.832 Saltbr-in 3.149 HRD-in -81.68, -58.97 75.36, 18.24 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.89, 148.76 APE9-dihe-na 77.48, 128.01 APE8-dihe-in -56.0, 131.29 APE8-rot-in 290.87 APE67-dihe-in -61.94, -19.93 -42.42, -49.49 APE12-dist-in 12.912 APE11-dist-in 10.136 APE10-dist-in 7.275 APE9-dist-in 3.215 None TPO160 TPO160 XRAY 2.398 0.211 0.217 A 302 298 0 0 0 0 [[4, 286]] 1.0 9esk CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESLA 1 297 298.0 V3U:60301,V3U:60302,V3U:60303 Type1,Allosteric,Allosteric Active DFGin 6.621 15.27 BLAminus -138.4, 178.74 56.73, 85.65 -102.78, 26.09 280.14, 70.92 -77.54, -19.71 in-in in 8.794 Saltbr-in 3.258 HRD-in -84.5, -55.59 73.62, 15.91 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -52.9, 163.47 APE9-dihe-na 75.95, 128.72 APE8-dihe-in -54.92, 137.6 APE8-rot-in 298.46 APE67-dihe-in -62.23, -17.31 -55.18, -44.63 APE12-dist-in 12.988 APE11-dist-in 11.939 APE10-dist-in 7.114 APE9-dist-in 3.154 None TPO160 TPO160 XRAY 2.392 0.217 0.22 A 302 297 0 0 0 0 [[4, 286]] 1.0 9esl CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET3C 1 296 298.0 1P8:60301,1P8:60302,1P8:60303 Type1,Allosteric,Allosteric Active DFGin 6.634 15.417 BLAminus -136.42, -175.2 49.61, 75.4 -86.05, 23.32 281.27, 67.67 -65.65, -24.86 in-in in 8.523 Saltbr-in 2.969 HRD-in -85.78, -54.86 74.66, 10.97 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.99, 147.59 APE9-dihe-na 75.0, 128.74 APE8-dihe-in -56.23, 140.22 APE8-rot-in 313.04 APE67-dihe-in -53.49, -26.15 -43.22, -56.6 APE12-dist-in 12.74 APE11-dist-in 10.131 APE10-dist-in 6.699 APE9-dist-in 3.146 None TPO160 TPO160 XRAY 2.34 0.185 0.221 C 302 265 31 0 0 0 [[4, 286]] 1.0 9et3 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET6C 1 296 298.0 HHQ:60301,HHQ:60302,HHQ:60303 Type1,Allosteric,Allosteric Active DFGin 6.873 15.729 BLAminus -138.12, -175.76 50.55, 79.21 -99.63, 40.16 275.32, 72.76 -79.96, -35.84 in-in in 8.822 Saltbr-in 3.04 HRD-in -79.3, -57.91 70.96, 13.7 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.02, -81.33 APE9-dihe-na -75.9, 158.42 APE8-dihe-in -63.8, 136.86 APE8-rot-in 315.58 APE67-dihe-in -58.45, -31.02 -40.63, -49.71 APE12-dist-in 12.649 APE11-dist-in 9.98 APE10-dist-in 6.835 APE9-dist-in 3.427 None TPO160 TPO160 XRAY 2.553 0.224 0.239 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et6 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ET8C 1 296 298.0 IIS:60301,IIS:60302,IIS:60303 Type1,Allosteric,Allosteric Active DFGin 6.522 15.277 BLAminus -138.22, -178.04 53.64, 77.44 -93.34, 27.5 282.32, 70.76 -68.0, -30.89 in-in in 8.567 Saltbr-in 2.796 HRD-in -80.95, -56.88 70.51, 15.08 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.44, 149.31 APE9-dihe-na 74.52, 129.52 APE8-dihe-in -54.76, 135.97 APE8-rot-in 303.9 APE67-dihe-in -62.13, -18.99 -42.4, -52.2 APE12-dist-in 12.842 APE11-dist-in 10.128 APE10-dist-in 6.95 APE9-dist-in 3.297 None TPO160 TPO160 XRAY 2.31 0.226 0.242 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et8 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ETBC 1 296 298.0 PYZ:60501,PYZ:60502,PYZ:60504 Type1,Allosteric,Allosteric Active DFGin 6.746 15.019 BLAminus -143.48, -178.64 51.51, 80.46 -98.47, 34.67 277.11, 78.33 -78.48, -28.12 in-in in 8.406 Saltbr-in 2.918 HRD-in -77.32, -49.73 69.21, 13.85 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.33, 153.34 APE9-dihe-na 65.12, 133.84 APE8-dihe-in -56.36, 138.43 APE8-rot-in 308.36 APE67-dihe-in -58.62, -30.85 -38.23, -52.66 APE12-dist-in 12.539 APE11-dist-in 9.601 APE10-dist-in 6.617 APE9-dist-in 3.468 None TPO160 TPO160 XRAY 2.76 0.213 0.228 C 302 284 12 0 0 0 [[4, 286]] 1.0 9etb CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ETPC 1 296 298.0 BYZ:60501,BYZ:60502,BYZ:60503 Type1,Allosteric,Allosteric Active DFGin 6.563 15.026 BLAminus -139.85, -178.12 50.6, 80.08 -91.54, 27.1 284.21, 67.12 -60.57, -29.59 in-in in 8.597 Saltbr-in 2.956 HRD-in -84.41, -56.87 79.21, 8.08 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.1, 146.93 APE9-dihe-na 73.24, 128.07 APE8-dihe-in -58.4, 133.61 APE8-rot-in 297.06 APE67-dihe-in -57.21, -23.28 -33.45, -54.48 APE12-dist-in 12.759 APE11-dist-in 9.665 APE10-dist-in 6.816 APE9-dist-in 3.36 None TPO160 TPO160 XRAY 2.48 0.202 0.231 C 302 279 17 0 0 0 [[4, 286]] 1.0 9etp CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESJA 1 296 298.0 HHT:60601,HHT:60602,HHT:60603,HHT:60604 Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.527 15.324 BLAminus -137.61, -177.13 52.74, 75.68 -90.81, 24.42 279.7, 71.63 -65.27, -23.85 in-in in 8.726 Saltbr-in 3.1 HRD-in -83.71, -57.04 74.68, 18.49 in-in-in SNCiii in-in ActLoopNT-in 3.032 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.23, 145.1 APE9-dihe-na 79.14, 127.92 APE8-dihe-in -56.7, 137.49 APE8-rot-in 297.98 APE67-dihe-in -59.94, -16.79 -51.82, -49.73 APE12-dist-in 12.876 APE11-dist-in 10.06 APE10-dist-in 7.034 APE9-dist-in 3.266 None TPO160 TPO160 XRAY 2.37 0.218 0.223 A 302 296 0 0 0 0 [[4, 286]] 1.0 9esj CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESQA 1 296 298.0 IT4:60601,IT4:60602,IT4:60603,IT4:60604 Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.573 15.319 BLAminus -138.63, 177.23 53.97, 82.44 -94.2, 22.34 276.67, 75.86 -65.53, -24.16 in-in in 8.618 Saltbr-in 2.754 HRD-in -82.0, -53.66 73.59, 16.79 in-in-in SNCiii in-in ActLoopNT-in 3.116 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.91, 166.55 APE9-dihe-na 80.06, 129.5 APE8-dihe-in -59.98, 139.75 APE8-rot-in 298.87 APE67-dihe-in -65.21, -16.21 -49.51, -47.69 APE12-dist-in 13.141 APE11-dist-in 11.71 APE10-dist-in 7.098 APE9-dist-in 3.16 None TPO160 TPO160 XRAY 2.38 0.206 0.21 A 302 296 0 0 0 0 [[4, 286]] 1.0 9esq CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ESVA 1 298 298.0 3Z7:60601,3Z7:60602,3Z7:60603,3Z7:60604 Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.66 15.169 BLAminus -141.68, -175.45 45.66, 89.4 -98.16, 27.65 279.63, 71.93 -70.26, -29.25 in-in in 8.594 Saltbr-in 3.495 HRD-in -83.94, -54.63 72.69, 21.44 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.28, 170.55 APE9-dihe-na 72.91, 133.83 APE8-dihe-in -55.57, 128.45 APE8-rot-in 293.2 APE67-dihe-in -57.93, -20.57 -41.03, -48.86 APE12-dist-in 12.894 APE11-dist-in 12.234 APE10-dist-in 7.324 APE9-dist-in 3.227 None TPO160 TPO160 XRAY 2.397 0.227 0.229 A 302 298 0 0 0 0 [[4, 286]] 1.0 9esv CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9ETPA 1 297 298.0 BYZ:60601,BYZ:60603,BYZ:60604,BYZ:60605,BYZ:60606,BYZ:60607 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Active DFGin 6.84 15.494 BLAminus -127.49, -178.48 53.77, 85.13 -106.7, 35.09 276.24, 76.74 -80.48, -25.81 in-in in 8.546 Saltbr-in 3.046 HRD-in -77.4, -56.67 72.11, 14.41 in-in-in SNCiii in-in ActLoopNT-in 2.95 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.24, 146.07 APE9-dihe-na 79.12, 126.78 APE8-dihe-in -56.13, 139.51 APE8-rot-in 303.8 APE67-dihe-in -55.08, -20.41 -52.32, -47.85 APE12-dist-in 12.587 APE11-dist-in 9.765 APE10-dist-in 6.877 APE9-dist-in 3.285 None TPO160 TPO160 XRAY 2.48 0.202 0.231 A 302 294 3 0 0 0 [[4, 286]] 1.0 9etp CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3BHUC 1 296 298.0 MHR:60299 Type1.5_Back Active DFGin 6.711 14.747 BLAminus -135.55, 171.6 58.78, 89.32 -103.71, 20.04 281.06, 67.57 -60.23, -27.81 in-in in 8.385 Saltbr-in 2.558 HRD-in -83.56, -56.59 72.77, 13.78 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -30.58, 137.53 APE9-dihe-na 72.29, 126.42 APE8-dihe-in -48.13, 131.39 APE8-rot-in 307.87 APE67-dihe-in -59.11, -18.02 -39.31, -52.67 APE12-dist-in 12.706 APE11-dist-in 9.599 APE10-dist-in 7.189 APE9-dist-in 3.322 None TPO160 TPO160 XRAY 2.3 0.197 0.24 C 300 270 26 0 0 0 [[4, 286]] 1.0 3bhu CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8BZOA 14 297 298.0 No_ligand No_ligand Inactive DFGin 6.628 16.75 ABAminus -113.33, -60.04 -92.34, 117.63 -115.4, 17.23 269.19, 90.3 -63.34, -41.25 out-none out 10.219 Saltbr-none 999.0 HRD-out -86.82, 152.4 -117.77, -56.48 none-in-out SNCnio in-out ActLoopNT-in 3.194 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -98.87, -25.79 APE9-dihe-na -64.18, 153.29 APE8-dihe-in -63.18, 147.0 APE8-rot-out 47.23 APE67-dihe-in -65.24, -14.81 -65.84, -44.21 APE12-dist-in 9.694 APE11-dist-in 12.285 APE10-dist-in 6.835 APE9-dist-in 5.533 None TPO160 TPO160 EM 3.5 999.0 999.0 A 297 284 10 0 0 0 [[4, 286]] 1.0 8bzo CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5NEVA 1 295 298.0 72L:60301 Type1 Inactive DFGin 7.05 15.722 ABAminus -138.48, -8.77 -130.24, 91.18 -84.62, 13.88 280.22, 71.78 -70.55, -13.54 in-out in 8.796 Saltbr-out 3.697 HRD-in -77.87, -47.01 62.16, 19.64 out-in-out SNCoio in-out ActLoopNT-in 3.196 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.01, -38.47 APE9-dihe-na -96.82, 160.63 APE8-dihe-in -60.36, 142.07 APE8-rot-out 80.07 APE67-dihe-in -59.09, -25.56 -48.5, -47.43 APE12-dist-in 13.216 APE11-dist-in 11.905 APE10-dist-in 7.98 APE9-dist-in 3.72 None TPO160 TPO160 XRAY 2.97 0.22 0.261 A 303 295 0 0 0 0 [[4, 286]] 1.0 5nev CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5NEVC 1 296 298.0 72L:60301 Type1 Inactive DFGin 6.939 15.882 ABAminus -143.97, -12.19 -126.52, 90.93 -83.33, 12.48 277.79, 75.94 -69.32, -11.34 in-out in 8.874 Saltbr-out 3.991 HRD-out -97.5, 94.45 -92.19, 48.01 out-in-in SNCoii in-in ActLoopNT-in 3.204 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.27, -51.5 APE9-dihe-na -94.91, 150.97 APE8-dihe-in -53.84, 139.76 APE8-rot-in 308.05 APE67-dihe-in -58.52, -25.48 -46.89, -47.67 APE12-dist-in 13.121 APE11-dist-in 11.579 APE10-dist-in 7.239 APE9-dist-in 3.652 None TPO160 TPO160 XRAY 2.97 0.22 0.261 C 303 296 0 0 0 0 [[4, 286]] 1.0 5nev CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOOA 1 297 298.0 ATP:60302 ATPlike Inactive DFGin 6.651 15.121 BLAminus -137.3, -178.29 51.93, 74.48 -88.78, 23.73 283.58, 71.37 -66.89, -17.34 in-in in 8.754 Saltbr-in 2.774 HRD-in -82.21, -55.51 72.81, 10.91 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.74, 151.81 APE9-dihe-na 71.22, 125.56 APE8-dihe-in -63.52, 145.17 APE8-rot-out 106.26 APE67-dihe-in -59.56, -25.92 -46.12, -48.45 APE12-dist-in 12.954 APE11-dist-in 10.307 APE10-dist-in 7.133 APE9-dist-in 3.247 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 A 299 293 4 0 0 0 [[4, 286]] 1.0 4eoo CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOOC 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.441 15.255 BLAminus -132.94, -176.35 50.17, 74.17 -84.23, 27.4 283.88, 71.77 -62.65, -24.02 in-in in 8.772 Saltbr-in 2.725 HRD-in -84.21, -52.66 66.89, 14.22 in-in-out SNCiio in-out ActLoopNT-in 2.986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.67, 158.22 APE9-dihe-na 65.39, 129.96 APE8-dihe-in -70.44, 149.36 APE8-rot-out 84.06 APE67-dihe-in -53.86, -24.11 -49.71, -53.55 APE12-dist-in 12.807 APE11-dist-in 10.003 APE10-dist-in 6.75 APE9-dist-in 3.286 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 C 299 296 0 0 0 0 [[4, 286]] 1.0 4eoo CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOMA 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.766 15.173 BLAminus -135.89, -179.95 56.75, 76.33 -93.68, 18.3 281.75, 72.51 -65.02, -17.06 in-in in 8.656 Saltbr-in 2.954 HRD-in -79.7, -58.84 74.79, 7.53 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 71.17, 129.47 APE9-dihe-na 73.49, 129.68 APE8-dihe-in -66.58, 140.55 APE8-rot-out 117.21 APE67-dihe-in -54.12, -27.93 -44.4, -51.19 APE12-dist-in 13.269 APE11-dist-in 9.227 APE10-dist-in 7.153 APE9-dist-in 3.259 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 A 301 295 2 0 0 0 [[4, 286]] 1.0 4eom CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOMC 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.612 15.121 BLAminus -134.3, 179.46 56.9, 73.57 -89.28, 27.08 288.28, 71.72 -61.57, -29.46 in-in in 8.464 Saltbr-in 2.764 HRD-in -79.86, -55.51 70.21, 14.99 in-in-out SNCiio in-out ActLoopNT-in 2.988 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.3, 158.32 APE9-dihe-na 61.45, 125.91 APE8-dihe-in -61.76, 140.91 APE8-rot-out 72.97 APE67-dihe-in -49.53, -25.94 -36.27, -61.03 APE12-dist-in 12.846 APE11-dist-in 9.68 APE10-dist-in 6.944 APE9-dist-in 3.36 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 C 301 272 24 0 0 0 [[4, 286]] 1.0 4eom CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1FINA 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.269 15.397 BLAminus -145.66, 175.42 60.17, 70.41 -88.62, 22.31 287.3, 65.31 -62.81, -23.63 in-in in 8.878 Saltbr-in 3.066 HRD-in -75.81, -52.6 66.76, 11.52 in-in-out SNCiio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -159.69, 149.42 APE9-dihe-na -56.35, 161.85 APE8-dihe-in -65.27, 149.59 APE8-rot-out 191.08 APE67-dihe-in -48.48, -30.03 -41.87, -56.23 APE12-dist-in 10.428 APE11-dist-out 5.924 APE10-dist-out 8.991 APE9-dist-in 4.147 None None None XRAY 2.3 0.208 999.0 A 298 298 0 0 0 0 [[4, 286]] 1.0 1fin CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1FINC 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.329 16.114 BLAminus -126.26, 177.09 60.06, 80.37 -100.41, 24.94 280.63, 71.46 -64.88, -37.23 in-in in 9.234 Saltbr-in 3.016 HRD-in -71.64, -45.48 67.73, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.657 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -100.08, 164.84 APE9-dihe-na -64.11, 161.66 APE8-dihe-in -58.82, 141.21 APE8-rot-in 296.75 APE67-dihe-in -52.5, -36.66 -49.82, -46.41 APE12-dist-in 10.426 APE11-dist-out 6.239 APE10-dist-out 9.723 APE9-dist-in 3.907 None None None XRAY 2.3 0.208 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 1fin CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1FQ1B 1 296 298.0 ATP:381 ATPlike Inactive DFGin 6.774 15.622 BLAminus -151.24, -169.54 37.68, 67.63 -81.17, 26.85 274.26, 50.62 -66.75, -18.36 in-out in 9.807 Saltbr-out 3.73 HRD-in -76.57, -60.94 80.93, -25.61 out-in-out SNCoio in-out ActLoopNT-in 2.61 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oioo APE10-dihe-na -104.21, 92.46 APE9-dihe-na -93.56, -175.8 APE8-dihe-out -64.18, -46.74 APE8-rot-in 317.22 APE67-dihe-out -56.53, -27.84 69.72, -12.02 APE12-dist-out 16.113 APE11-dist-in 11.902 APE10-dist-out 15.594 APE9-dist-out 10.131 None TPO160 TPO160 XRAY 3.0 0.235 0.313 B 298 296 0 0 0 0 [[4, 286]] 1.0 1fq1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9I9JK 6 284 298.0 ADP:60301 ATPlike Inactive DFGin 7.502 16.779 BLAminus -158.16, 171.41 58.55, 63.81 -89.46, 61.19 266.29, 72.56 161.2, 999.0 in-out in 9.119 Saltbr-out 5.255 HRD-in -89.48, -59.44 66.59, -3.23 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -47.83 APE8-dihe-out -98.29, 31.77 APE8-rot-out 77.96 APE67-dihe-in -64.85, -20.6 -65.62, -27.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.13 None None None EM 3.1 999.0 999.0 K 301 246 37 0 0 16 [[4, 286]] 1.0 9i9j CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9I9KK 2 292 298.0 ADP:60301 ATPlike Inactive DFGin 7.302 15.906 BLAminus -142.34, -176.15 60.61, 65.17 -90.86, 48.23 288.67, 80.56 -88.9, -30.85 out-out out 10.486 Saltbr-out 5.65 HRD-in -65.4, -52.43 72.61, -10.3 out-in-out SNCoio in-out ActLoopNT-in 2.558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -73.37, 146.13 APE9-dihe-na -115.04, 137.49 APE8-dihe-in -60.96, 144.59 APE8-rot-out 184.92 APE67-dihe-in -75.1, -11.28 -107.26, -12.43 APE12-dist-in 12.011 APE11-dist-in 8.187 APE10-dist-out 12.049 APE9-dist-out 7.548 None None None EM 2.4 999.0 999.0 K 301 276 15 0 0 0 [[4, 286]] 1.0 9i9k CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9QCVK 1 292 298.0 ANP:60301 ATPlike Inactive DFGin 6.495 15.807 BLAminus -144.96, -178.89 57.85, 64.57 -85.72, 49.93 282.03, 73.0 -84.65, -33.03 in-out in 9.3 Saltbr-out 4.618 HRD-in -70.41, -54.19 69.05, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.576 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -164.79, 153.04 APE9-dihe-na -68.87, 164.19 APE8-dihe-in -61.62, 153.89 APE8-rot-out 41.16 APE67-dihe-in -67.77, -23.98 -60.52, -33.7 APE12-dist-in 11.155 APE11-dist-out 6.112 APE10-dist-out 8.897 APE9-dist-in 4.078 None None None EM 2.5 999.0 999.0 K 301 292 0 0 0 0 [[4, 286]] 1.0 9qcv CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOQA 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.603 15.258 BLAminus -136.2, -179.04 55.17, 77.3 -91.43, 19.33 282.26, 72.55 -64.29, -18.87 in-in in 8.786 Saltbr-in 2.845 HRD-in -79.78, -53.17 69.74, 9.41 in-in-out SNCiio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 62.26, 128.16 APE9-dihe-na 76.05, 127.33 APE8-dihe-in -62.55, 137.94 APE8-rot-out 115.71 APE67-dihe-in -58.94, -23.33 -43.56, -48.15 APE12-dist-in 13.361 APE11-dist-in 9.158 APE10-dist-in 7.177 APE9-dist-in 3.246 None TPO160 TPO160 XRAY 2.15 0.201 0.234 A 301 294 3 0 0 0 [[4, 286]] 1.0 4eoq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOQC 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.583 15.249 BLAminus -140.92, -177.14 51.0, 72.99 -85.26, 24.65 284.32, 71.69 -63.95, -27.55 in-in in 8.649 Saltbr-in 2.713 HRD-in -79.85, -57.3 73.26, 6.95 in-in-out SNCiio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.95, 149.43 APE9-dihe-na 70.01, 126.65 APE8-dihe-in -62.68, 144.35 APE8-rot-out 86.91 APE67-dihe-in -60.3, -23.97 -41.77, -51.35 APE12-dist-in 12.923 APE11-dist-in 9.988 APE10-dist-in 7.055 APE9-dist-in 3.18 None TPO160 TPO160 XRAY 2.15 0.201 0.234 C 301 272 24 0 0 0 [[4, 286]] 1.0 4eoq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOJA 1 298 298.0 ATP:60301 ATPlike Inactive DFGin 6.671 15.377 BLAminus -134.08, 177.58 53.89, 78.08 -94.34, 17.78 277.91, 75.6 -65.2, -18.6 in-in in 8.642 Saltbr-in 2.923 HRD-in -77.88, -54.19 68.96, 13.72 in-in-out SNCiio in-out ActLoopNT-in 2.952 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -80.75, 158.76 APE9-dihe-na 76.84, 131.84 APE8-dihe-in -62.19, 141.78 APE8-rot-out 119.83 APE67-dihe-in -58.91, -24.4 -48.51, -47.68 APE12-dist-in 13.309 APE11-dist-in 9.149 APE10-dist-in 7.333 APE9-dist-in 3.214 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 A 302 294 4 0 0 0 [[4, 286]] 1.0 4eoj CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOJC 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.604 15.375 BLAminus -136.46, -177.75 51.71, 75.47 -89.77, 20.18 280.05, 73.98 -59.21, -28.77 in-in in 8.59 Saltbr-in 2.63 HRD-in -79.08, -54.75 70.82, 10.21 in-in-out SNCiio in-out ActLoopNT-in 2.918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.67, 155.4 APE9-dihe-na 67.15, 126.49 APE8-dihe-in -61.14, 141.64 APE8-rot-out 49.99 APE67-dihe-in -62.84, -21.66 -42.97, -49.5 APE12-dist-in 12.897 APE11-dist-in 9.826 APE10-dist-in 6.834 APE9-dist-in 3.184 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 C 302 279 17 0 0 0 [[4, 286]] 1.0 4eoj CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8VQ3A 1 297 298.0 A1AC4:60401 Allosteric Inactive DFGin 7.129 16.245 BLAminus -139.03, -178.82 55.37, 68.52 -84.82, 20.75 285.09, 60.51 -59.19, -33.27 in-in in 9.405 Saltbr-in 3.179 HRD-in -78.53, -53.8 72.8, -2.81 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -85.33, 113.73 APE9-dihe-na -131.15, 171.47 APE8-dihe-in -69.92, 158.21 APE8-rot-out 166.59 APE67-dihe-in -59.5, -27.96 -109.05, -50.41 APE12-dist-out 14.237 APE11-dist-in 8.79 APE10-dist-out 9.766 APE9-dist-in 5.595 None TPO160 TPO160 XRAY 1.84 0.2 0.217 A 298 297 0 0 0 0 [[4, 286]] 1.0 8vq3 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8VQ4A 1 297 298.0 A1AC5:60401 Allosteric Inactive DFGin 7.213 16.378 BLAminus -141.63, 178.83 59.45, 68.52 -87.1, 19.52 283.33, 69.16 -60.54, -32.28 in-in in 9.459 Saltbr-in 3.312 HRD-in -77.67, -52.1 70.93, 1.48 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 125.47 APE8-dihe-in -48.09, 139.52 APE8-rot-out 176.74 APE67-dihe-in -54.81, -27.41 -57.14, -48.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.952 None TPO160 TPO160 XRAY 1.9 0.193 0.219 A 298 294 3 0 0 3 [[4, 286]] 1.0 8vq4 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2JGZA 1 288 298.0 No_ligand No_ligand Inactive DFGin 6.82 15.332 BLAminus -119.18, -174.9 51.61, 74.66 -88.82, 26.74 280.31, 63.91 -52.44, -56.56 in-out in 8.939 Saltbr-out 4.01 HRD-in -84.27, -44.78 57.22, 21.87 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.7, 145.88 APE9-dihe-na 66.31, 139.22 APE8-dihe-in -58.76, 138.9 APE8-rot-in 308.55 APE67-dihe-in -54.56, -23.64 -38.6, -60.2 APE12-dist-in 12.727 APE11-dist-in 10.569 APE10-dist-in 6.998 APE9-dist-in 3.411 None TPO160 TPO160 XRAY 2.9 0.208 0.275 A 289 288 0 0 0 0 [[4, 286]] 1.0 2jgz CMGC_CDK2_HUMAN CMGC 5.6e-90 308.0 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9HIUB 1 294 298.0 No_ligand No_ligand Inactive DFGin 6.138 15.551 BLAminus -148.76, -176.18 57.04, 61.27 -85.4, 17.37 274.29, 71.94 -63.88, -33.63 in-out in 8.936 Saltbr-out 3.969 HRD-in -69.53, -59.27 63.5, 5.02 out-in-out SNCoio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -161.4 APE8-rot-out 171.33 APE67-dihe-in -63.0, -40.52 -76.12, -32.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.2 999.0 999.0 B 297 285 9 0 0 5 [[4, 286]] 1.0 9hiu CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9HIWB 1 294 298.0 No_ligand No_ligand Inactive DFGin 6.211 15.447 BLAminus -145.37, 174.8 58.15, 65.71 -84.54, 21.5 277.88, 73.9 -62.68, -38.2 in-out in 8.996 Saltbr-out 3.949 HRD-in -66.48, -50.82 64.79, 0.22 out-in-out SNCoio in-out ActLoopNT-in 2.9 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -146.41 APE8-rot-out 166.74 APE67-dihe-in -66.55, -26.76 -98.98, -25.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.1 999.0 999.0 B 297 285 9 0 0 5 [[4, 286]] 1.0 9hiw CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9HJ1B 1 294 298.0 No_ligand No_ligand Inactive DFGin 6.558 15.571 BLAminus -143.27, 176.26 57.52, 63.37 -86.62, 21.76 277.25, 80.02 -66.38, -38.66 in-out in 8.901 Saltbr-out 3.724 HRD-in -62.89, -50.76 65.1, -1.08 out-in-out SNCoio in-out ActLoopNT-in 2.872 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -157.08 APE8-rot-out 169.53 APE67-dihe-in -64.07, -38.35 -94.94, -27.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 2.9 999.0 999.0 B 297 285 9 0 0 5 [[4, 286]] 1.0 9hj1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1F5QA 1 298 298.0 No_ligand No_ligand Inactive DFGin 7.409 15.633 BLAminus -138.07, 171.74 53.27, 74.6 -86.39, 38.32 291.44, 74.52 -69.55, -17.11 in-in in 9.155 Saltbr-in 3.145 HRD-in -75.78, -43.37 70.11, -10.81 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -76.02, 102.77 APE9-dihe-na -78.65, -116.0 APE8-dihe-in -118.19, 147.42 APE8-rot-out 182.09 APE67-dihe-in -66.33, -17.96 -106.56, 7.87 APE12-dist-in 10.706 APE11-dist-out 6.808 APE10-dist-out 11.652 APE9-dist-out 8.859 None None None XRAY 2.5 0.234 0.278 A 298 296 2 0 0 0 [[4, 286]] 1.0 1f5q CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1F5QC 1 297 298.0 No_ligand No_ligand Inactive DFGin 7.205 15.404 BLAminus -141.49, 164.85 64.2, 73.44 -87.93, 33.24 295.33, 71.82 -63.07, -25.5 in-out in 8.974 Saltbr-out 3.905 HRD-in -72.14, -50.95 71.24, 5.7 out-in-out SNCoio in-out ActLoopNT-in 2.854 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -24.69, 81.59 APE9-dihe-na -53.51, 144.38 APE8-dihe-in -123.48, 78.82 APE8-rot-out 179.54 APE67-dihe-in -62.46, -15.61 -56.76, -8.76 APE12-dist-in 10.566 APE11-dist-out 6.86 APE10-dist-out 11.839 APE9-dist-out 8.581 None None None XRAY 2.5 0.234 0.278 C 298 288 9 0 0 0 [[4, 286]] 1.0 1f5q CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1JSUA 13 298 298.0 No_ligand No_ligand Inactive DFGin 6.19 16.469 BLAminus -124.79, 164.29 63.39, 89.08 -107.21, 29.25 285.85, 76.21 -70.71, -21.7 out-out out 10.235 Saltbr-out 5.128 HRD-in -73.23, -47.83 69.45, 5.62 out-in-in SNCoii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.75, 175.46 APE9-dihe-na 74.1, 131.57 APE8-dihe-in -52.14, 129.1 APE8-rot-in 292.84 APE67-dihe-in -50.28, -24.78 -35.42, -59.56 APE12-dist-in 13.438 APE11-dist-in 12.961 APE10-dist-in 7.497 APE9-dist-in 3.376 None TPO160 TPO160 XRAY 2.3 0.192 0.26 A 298 286 9 0 0 0 [[4, 286]] 1.0 1jsu CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OKVA 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.444 16.078 BLAminus -120.81, -179.67 52.54, 72.67 -88.14, 19.11 277.86, 71.02 -53.88, -33.16 in-in in 8.821 Saltbr-in 2.628 HRD-in -74.58, -48.92 81.43, -17.3 in-in-out SNCiio in-out ActLoopNT-in 3.087 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -113.96, -18.23 APE9-dihe-na -58.99, -48.36 APE8-dihe-out 147.59, 117.89 APE8-rot-out 166.33 APE67-dihe-in -65.97, -14.56 -45.73, -49.07 APE12-dist-out 15.04 APE11-dist-in 11.936 APE10-dist-out 8.675 APE9-dist-in 5.151 None None None XRAY 2.4 0.201 0.278 A 298 296 0 0 0 0 [[4, 286]] 1.0 1okv CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OKVC 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.774 16.283 BLAminus -143.79, -172.6 54.38, 65.18 -88.52, 20.25 276.38, 68.39 -64.37, -24.11 in-out in 9.192 Saltbr-out 4.586 HRD-in -73.64, -57.29 84.97, -6.97 out-in-out SNCoio in-out ActLoopNT-in 2.795 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -104.0, 60.23 APE9-dihe-na -130.86, 156.74 APE8-dihe-in -57.98, 139.17 APE8-rot-out 120.2 APE67-dihe-in -55.21, -29.99 -99.41, -5.27 APE12-dist-out 15.556 APE11-dist-in 10.018 APE10-dist-out 12.969 APE9-dist-out 8.857 None None None XRAY 2.4 0.201 0.278 C 298 296 0 0 0 0 [[4, 286]] 1.0 1okv CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OKWA 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.484 16.126 BLAminus -137.86, 174.82 68.57, 68.02 -98.08, 26.26 277.67, 60.82 -68.53, -22.75 in-in in 8.981 Saltbr-in 3.544 HRD-in -88.52, -48.72 79.1, -22.5 in-in-out SNCiio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -78.49, 74.79 APE9-dihe-na -138.74, 155.36 APE8-dihe-in -61.05, 165.85 APE8-rot-out 184.07 APE67-dihe-in -66.44, -21.76 -100.17, -34.65 APE12-dist-out 15.341 APE11-dist-in 9.925 APE10-dist-out 9.606 APE9-dist-out 6.14 None None None XRAY 2.5 0.175 0.253 A 298 296 0 0 0 0 [[4, 286]] 1.0 1okw CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OKWC 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.417 15.953 BLAminus -139.6, 173.1 64.79, 70.69 -95.36, 23.49 272.31, 64.24 -64.28, -22.11 in-in in 8.901 Saltbr-in 3.267 HRD-in -77.15, -48.85 78.53, -9.81 in-in-out SNCiio in-out ActLoopNT-in 2.987 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -119.07, 84.55 APE9-dihe-na -93.96, -176.51 APE8-dihe-in -80.28, 151.09 APE8-rot-out 185.01 APE67-dihe-in -56.22, -29.25 -111.15, -2.69 APE12-dist-out 15.272 APE11-dist-in 9.091 APE10-dist-out 10.956 APE9-dist-out 6.866 None None None XRAY 2.5 0.175 0.253 C 298 296 0 0 0 0 [[4, 286]] 1.0 1okw CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OL1A 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.408 15.545 BLAminus -140.82, 172.23 59.17, 80.76 -93.23, 29.91 271.28, 60.47 -67.99, -40.25 in-in in 8.408 Saltbr-in 2.915 HRD-in -95.64, -45.73 68.37, -0.63 in-in-out SNCiio in-out ActLoopNT-in 3.012 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioi APE10-dihe-na -101.47, 3.34 APE9-dihe-na -94.64, -32.92 APE8-dihe-out 139.88, 160.77 APE8-rot-in 283.05 APE67-dihe-in -59.35, -30.39 -95.92, -51.95 APE12-dist-out 15.071 APE11-dist-in 11.17 APE10-dist-out 8.139 APE9-dist-in 4.921 None None None XRAY 2.9 0.209 0.284 A 298 296 0 0 0 0 [[4, 286]] 1.0 1ol1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OL1C 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.699 15.724 BLAminus -161.99, 173.47 66.17, 68.99 -93.37, 29.69 275.55, 55.92 -61.88, -36.75 in-in in 8.896 Saltbr-in 3.081 HRD-in -78.75, -57.42 81.19, 0.27 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioi APE10-dihe-na 61.11, -103.73 APE9-dihe-na 48.89, -112.15 APE8-dihe-out -157.24, -69.82 APE8-rot-out 2.59 APE67-dihe-out -45.45, -36.33 96.74, -73.48 APE12-dist-in 13.453 APE11-dist-in 10.076 APE10-dist-out 8.134 APE9-dist-in 4.879 None None None XRAY 2.9 0.209 0.284 C 298 296 0 0 0 0 [[4, 286]] 1.0 1ol1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OL2A 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.452 15.178 BLAminus -120.84, -174.45 48.91, 74.14 -88.83, 27.64 281.83, 69.44 -74.49, -21.64 in-in in 8.25 Saltbr-in 3.137 HRD-in -82.7, -44.63 87.48, -37.81 in-in-out SNCiio in-out ActLoopNT-in 2.741 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -104.1, 6.86 APE9-dihe-na -97.06, -44.6 APE8-dihe-out 147.22, 120.74 APE8-rot-out 174.14 APE67-dihe-in -64.66, -29.42 -59.01, -48.31 APE12-dist-out 14.923 APE11-dist-in 11.799 APE10-dist-out 8.677 APE9-dist-in 5.483 None None None XRAY 2.6 0.194 0.29 A 298 296 0 0 0 0 [[4, 286]] 1.0 1ol2 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OL2C 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.385 15.626 BLAminus -136.02, -168.49 52.37, 72.81 -90.41, 24.94 279.14, 62.11 -65.28, -29.14 in-in in 8.504 Saltbr-in 2.675 HRD-in -67.99, -46.22 80.57, -8.38 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -94.09, 71.79 APE9-dihe-na -107.39, 168.28 APE8-dihe-in -60.83, 133.72 APE8-rot-out 71.55 APE67-dihe-in -48.15, -33.44 -102.75, -3.43 APE12-dist-out 15.436 APE11-dist-in 9.617 APE10-dist-out 13.093 APE9-dist-out 8.703 None None None XRAY 2.6 0.194 0.29 C 298 296 0 0 0 0 [[4, 286]] 1.0 1ol2 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1URCA 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.512 14.981 BLAminus -129.95, 175.56 55.15, 83.89 -97.6, 32.32 291.84, 63.51 -71.22, -27.23 in-in in 8.341 Saltbr-in 3.061 HRD-in -94.24, -49.78 87.01, -13.05 in-in-out SNCiio in-out ActLoopNT-in 2.849 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oioo APE10-dihe-na -127.29, -40.73 APE9-dihe-na -65.24, -160.23 APE8-dihe-in -82.59, 155.77 APE8-rot-out 198.85 APE67-dihe-out 76.94, -57.2 -81.24, -148.21 APE12-dist-out 14.773 APE11-dist-in 11.005 APE10-dist-out 8.201 APE9-dist-out 6.666 None None None XRAY 2.6 0.177 0.254 A 298 296 0 0 0 0 [[4, 286]] 1.0 1urc CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1URCC 1 297 298.0 No_ligand No_ligand Inactive DFGin 6.524 15.349 BLAminus -139.3, 168.34 67.82, 71.56 -90.12, 30.22 284.71, 64.0 -56.18, -36.82 in-in in 8.248 Saltbr-in 3.017 HRD-in -76.88, -54.17 79.16, -8.55 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -115.87, 126.59 APE9-dihe-na -47.68, 173.83 APE8-dihe-in -109.65, 161.85 APE8-rot-in 305.52 APE67-dihe-in -50.71, -33.17 -102.69, -32.98 APE12-dist-out 15.057 APE11-dist-in 10.918 APE10-dist-in 7.87 APE9-dist-out 6.603 None None None XRAY 2.6 0.177 0.254 C 298 297 0 0 0 0 [[4, 286]] 1.0 1urc CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2V22A 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.459 15.492 BLAminus -132.44, 178.14 60.5, 75.27 -95.35, 22.95 275.6, 72.86 -49.4, -38.54 in-in in 8.576 Saltbr-in 2.78 HRD-in -76.19, -55.04 83.89, -15.21 in-in-out SNCiio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -86.69, 68.29 APE9-dihe-na -152.82, 33.68 APE8-dihe-out 63.56, 145.92 APE8-rot-out 217.61 APE67-dihe-in -67.06, -9.7 -100.44, -48.4 APE12-dist-out 14.865 APE11-dist-in 11.579 APE10-dist-out 9.334 APE9-dist-in 5.28 None None None XRAY 2.6 0.174 0.277 A 298 296 0 0 0 0 [[4, 286]] 1.0 2v22 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2V22C 1 297 298.0 No_ligand No_ligand Inactive DFGin 6.331 15.479 BLAminus -146.83, 177.32 52.95, 76.41 -87.8, 21.74 277.38, 65.05 -51.11, -39.67 in-in in 8.474 Saltbr-in 3.432 HRD-in -64.56, -46.03 68.73, -15.43 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -107.38, 80.17 APE9-dihe-na -132.24, 155.09 APE8-dihe-in -62.03, 145.84 APE8-rot-out 167.13 APE67-dihe-in -60.96, -28.05 -89.82, -49.35 APE12-dist-out 15.419 APE11-dist-in 10.033 APE10-dist-out 9.27 APE9-dist-in 5.726 None None None XRAY 2.6 0.174 0.277 C 298 297 0 0 0 0 [[4, 286]] 1.0 2v22 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WFYA 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.469 15.809 BLAminus -129.75, 175.75 62.42, 74.14 -93.98, 21.08 281.46, 65.37 -60.72, -22.48 in-out in 9.061 Saltbr-out 6.379 HRD-in -69.87, -51.87 88.77, -25.86 out-in-out SNCoio in-out ActLoopNT-in 2.823 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -104.24, -15.67 APE9-dihe-na -94.73, 79.23 APE8-dihe-out 36.75, 114.18 APE8-rot-out 202.36 APE67-dihe-in -72.54, -16.11 -61.07, -35.76 APE12-dist-out 14.976 APE11-dist-in 11.914 APE10-dist-out 9.009 APE9-dist-out 6.349 None None None XRAY 2.53 0.195 0.259 A 298 296 0 0 0 0 [[4, 286]] 1.0 2wfy CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WFYC 1 297 298.0 No_ligand No_ligand Inactive DFGin 6.679 16.186 BLAminus -141.19, 179.78 59.71, 73.1 -96.77, 21.07 273.92, 71.63 -56.41, -28.59 in-out in 8.985 Saltbr-out 4.526 HRD-in -70.6, -53.24 84.65, -12.77 out-in-out SNCoio in-out ActLoopNT-in 2.982 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -110.71, 8.78 APE9-dihe-na -67.27, 116.94 APE8-dihe-in -40.1, 145.37 APE8-rot-out 91.78 APE67-dihe-in -63.11, -28.51 -75.52, -20.96 APE12-dist-out 15.515 APE11-dist-in 10.104 APE10-dist-out 11.621 APE9-dist-out 6.75 None None None XRAY 2.53 0.195 0.259 C 298 297 0 0 0 0 [[4, 286]] 1.0 2wfy CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WHBA 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.286 15.171 BLAminus -121.93, 168.73 63.84, 89.73 -110.71, 19.58 281.17, 65.75 -54.28, -25.03 in-in in 8.639 Saltbr-in 3.308 HRD-in -68.38, -52.89 83.41, -8.21 in-in-out SNCiio in-out ActLoopNT-in 3.066 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioi APE10-dihe-na -118.47, 48.49 APE9-dihe-na -148.16, 52.77 APE8-dihe-out 65.52, 155.0 APE8-rot-in 283.14 APE67-dihe-in -46.44, -19.45 -113.22, -61.36 APE12-dist-out 14.786 APE11-dist-in 11.988 APE10-dist-out 8.793 APE9-dist-in 5.526 None None None XRAY 2.9 0.189 0.264 A 298 296 0 0 0 0 [[4, 286]] 1.0 2whb CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WHBC 1 297 298.0 No_ligand No_ligand Inactive DFGin 6.502 15.421 BLAminus -146.01, -173.35 41.98, 75.41 -92.68, 20.49 281.39, 65.9 -59.19, -37.47 in-in in 8.556 Saltbr-in 3.459 HRD-in -71.29, -45.65 74.78, -17.63 in-in-out SNCiio in-out ActLoopNT-in 2.979 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioi APE10-dihe-na -98.69, 73.38 APE9-dihe-na -150.46, 35.88 APE8-dihe-out 58.38, 135.63 APE8-rot-in 256.16 APE67-dihe-in -49.67, -33.51 -102.65, -53.6 APE12-dist-out 14.904 APE11-dist-in 10.857 APE10-dist-out 9.748 APE9-dist-in 5.97 None None None XRAY 2.9 0.189 0.264 C 298 297 0 0 0 0 [[4, 286]] 1.0 2whb CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5IF1A 1 298 298.0 No_ligand No_ligand Inactive DFGin 6.094 15.381 BLAminus -137.43, -174.52 43.73, 86.52 -101.84, 23.59 285.83, 70.6 -54.56, -38.41 in-in in 8.573 Saltbr-in 2.958 HRD-in -83.82, -51.99 75.85, -16.4 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -153.82, 139.29 APE9-dihe-na -47.73, 145.98 APE8-dihe-in -46.95, 154.13 APE8-rot-out 198.64 APE67-dihe-in -68.44, -24.11 -52.75, -43.3 APE12-dist-in 11.049 APE11-dist-out 6.129 APE10-dist-out 8.993 APE9-dist-in 3.976 None None None XRAY 2.61 0.19 0.236 A 298 298 0 0 0 0 [[4, 286]] 1.0 5if1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5IF1C 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.211 15.36 BLAminus -139.2, -174.49 53.76, 79.01 -103.15, 18.84 280.18, 72.88 -48.24, -37.81 in-in in 8.525 Saltbr-in 2.776 HRD-in -76.93, -53.21 80.62, -3.93 in-in-out SNCiio in-out ActLoopNT-in 2.99 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -105.55, 40.53 APE9-dihe-na -54.61, 119.45 APE8-dihe-out -116.22, -167.37 APE8-rot-out 184.29 APE67-dihe-in -73.46, -22.29 -91.2, -34.06 APE12-dist-in 12.629 APE11-dist-in 9.942 APE10-dist-out 8.925 APE9-dist-out 6.377 None None None XRAY 2.61 0.19 0.236 C 298 296 0 0 0 0 [[4, 286]] 1.0 5if1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6P3WA 1 298 298.0 No_ligand No_ligand Inactive DFGin 6.383 15.256 BLAminus -139.11, 178.96 55.88, 76.9 -95.56, 29.89 282.66, 70.84 -65.96, -13.03 in-in in 8.964 Saltbr-in 3.117 HRD-in -81.25, -53.11 69.58, 7.71 in-in-out SNCiio in-out ActLoopNT-in 2.794 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -154.18, 150.8 APE9-dihe-na -61.6, 156.17 APE8-dihe-in -59.43, 155.66 APE8-rot-out 186.9 APE67-dihe-in -57.18, -24.62 -51.59, -46.89 APE12-dist-in 11.107 APE11-dist-out 6.246 APE10-dist-out 9.163 APE9-dist-in 3.944 None None None XRAY 2.54 0.2 0.237 A 298 298 0 0 0 0 [[4, 286]] 1.0 6p3w CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6P3WC 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.343 15.754 BLAminus -139.35, 175.72 58.19, 71.13 -90.52, 28.64 281.02, 70.32 -63.15, -27.73 in-in in 9.237 Saltbr-in 3.241 HRD-in -82.0, -55.09 71.8, 0.84 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.51, 158.31 APE9-dihe-na -67.03, 164.28 APE8-dihe-in -53.2, 147.11 APE8-rot-in 323.66 APE67-dihe-in -58.81, -32.57 -51.42, -40.12 APE12-dist-in 11.385 APE11-dist-out 6.698 APE10-dist-out 9.732 APE9-dist-in 4.166 None None None XRAY 2.54 0.2 0.237 C 298 296 0 0 0 0 [[4, 286]] 1.0 6p3w CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7B5LL 13 298 298.0 No_ligand No_ligand Inactive DFGin 6.668 16.777 BLAminus -159.37, -170.5 58.23, 65.17 -90.27, 25.66 278.63, 99.6 -75.03, -21.38 out-out out 10.414 Saltbr-out 4.901 HRD-in -83.03, -61.13 65.98, 9.04 out-in-out SNCoio in-out ActLoopNT-in 3.401 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -120.72, -152.25 APE9-dihe-na -52.91, -65.47 APE8-dihe-in -175.87, 143.72 APE8-rot-out 174.23 APE67-dihe-in -69.97, -22.68 -55.73, -38.14 APE12-dist-in 13.204 APE11-dist-in 10.359 APE10-dist-out 8.748 APE9-dist-in 3.249 None TPO160 TPO160 EM 3.8 999.0 999.0 L 298 284 11 0 0 2 [[4, 286]] 1.0 7b5l CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7B5RL 13 298 298.0 No_ligand No_ligand Inactive DFGin 6.915 16.95 BLAminus -161.78, -169.14 57.49, 63.4 -93.04, 29.37 272.67, 109.31 -77.5, -17.83 out-out out 10.288 Saltbr-out 4.883 HRD-in -82.33, -61.79 67.76, 6.88 out-in-out SNCoio in-out ActLoopNT-in 3.119 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -126.01, -160.31 APE9-dihe-na -51.6, -65.48 APE8-dihe-in -176.61, 148.68 APE8-rot-out 187.15 APE67-dihe-in -75.42, -28.29 -61.57, -20.14 APE12-dist-in 13.445 APE11-dist-in 9.73 APE10-dist-out 9.18 APE9-dist-in 3.308 None TPO160 TPO160 EM 3.8 999.0 999.0 L 298 284 11 0 0 2 [[4, 286]] 1.0 7b5r CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8ROZA 1 298 298.0 No_ligand No_ligand Inactive DFGin 6.665 15.45 BLAminus -146.85, -178.58 57.04, 63.1 -84.71, 23.05 276.75, 81.02 -63.7, -33.06 in-out in 9.074 Saltbr-out 5.335 HRD-in -64.84, -52.8 64.14, 6.42 out-in-in SNCoii in-in ActLoopNT-in 2.633 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.19, -66.83 APE9-dihe-na -78.06, 149.53 APE8-dihe-in -57.99, 137.61 APE8-rot-in 275.96 APE67-dihe-in -65.57, -29.26 -55.51, -35.38 APE12-dist-in 12.972 APE11-dist-in 10.877 APE10-dist-in 6.79 APE9-dist-in 3.505 None PTR15,TPO160 PTR15,TPO160 EM 2.7 999.0 999.0 A 298 298 0 0 0 0 [[4, 286]] 1.0 8roz CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9D0WC 1 298 298.0 No_ligand No_ligand Inactive DFGin 6.71 15.607 BLAminus -142.76, 174.08 59.36, 65.83 -80.37, 18.14 274.15, 77.52 -62.17, -35.05 in-out in 9.166 Saltbr-out 3.829 HRD-in -67.33, -50.6 58.18, 14.57 out-in-in SNCoii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.57, 167.48 APE9-dihe-na 66.76, 152.47 APE8-dihe-in -65.46, 154.58 APE8-rot-in 313.38 APE67-dihe-in -69.23, -14.94 -60.37, -40.8 APE12-dist-in 13.505 APE11-dist-in 12.137 APE10-dist-in 7.413 APE9-dist-in 3.455 None TPO160 TPO160 EM 2.95 999.0 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 9d0w CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5UQ2A 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.558 15.673 BLAminus -135.72, 176.46 56.22, 78.5 -94.75, 31.43 279.25, 69.13 -68.67, -32.7 in-in in 9.307 Saltbr-in 2.963 HRD-in -85.45, -45.85 64.92, 5.26 in-in-out SNCiio in-out ActLoopNT-in 2.771 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.62, -45.62 APE9-dihe-na -157.2, 156.57 APE8-dihe-in -50.52, 138.9 APE8-rot-out 173.02 APE67-dihe-in -53.88, -32.0 -45.73, -36.16 APE12-dist-in 12.023 APE11-dist-in 8.869 APE10-dist-in 7.372 APE9-dist-in 4.185 None None None XRAY 2.7 0.218 0.275 A 301 296 0 0 0 0 [[4, 286]] 1.0 5uq2 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5UQ3A 19 292 298.0 No_ligand No_ligand Inactive DFGin 6.345 16.412 BLAminus -141.59, 169.76 60.28, 73.58 -86.8, 7.95 283.62, 89.48 -47.73, -37.18 out-in out 10.24 Saltbr-in 3.29 HRD-in -69.92, -53.79 58.55, 18.19 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -123.76, -74.2 APE9-dihe-na -86.53, 177.66 APE8-dihe-in -97.37, 112.1 APE8-rot-in 321.43 APE67-dihe-out -59.51, -20.87 56.52, -115.63 APE12-dist-in 13.196 APE11-dist-in 10.702 APE10-dist-in 7.789 APE9-dist-in 3.195 None None None XRAY 3.6 0.251 0.324 A 301 270 19 0 0 0 [[4, 286]] 1.0 5uq3 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9QCXK 1 292 298.0 No_ligand No_ligand Inactive DFGin 6.719 16.041 BLAminus -144.83, 178.78 57.4, 64.51 -84.56, 50.23 281.94, 71.88 -85.61, -30.32 in-in in 9.27 Saltbr-in 3.236 HRD-in -67.06, -51.02 68.85, 2.16 in-in-out SNCiio in-out ActLoopNT-in 2.595 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -167.43, 154.34 APE9-dihe-na -64.57, 162.43 APE8-dihe-in -64.83, 167.28 APE8-rot-out 196.35 APE67-dihe-in -64.39, -23.47 -61.67, -44.4 APE12-dist-in 10.937 APE11-dist-out 5.963 APE10-dist-out 8.949 APE9-dist-in 3.98 None None None EM 2.6 999.0 999.0 K 301 292 0 0 0 0 [[4, 286]] 1.0 9qcx CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6SG4A 28 294 298.0 No_ligand No_ligand Inactive DFGin 6.287 15.272 BLAminus -142.64, -177.22 52.35, 74.31 -90.44, 26.74 283.94, 75.05 -68.52, -27.31 in-out in 8.328 Saltbr-out 3.836 HRD-in -89.89, -55.83 73.82, 12.09 out-in-in SNCoii in-in ActLoopNT-in 3.094 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.38, 167.08 APE9-dihe-na 73.43, 135.34 APE8-dihe-in -50.66, 135.8 APE8-rot-in 300.95 APE67-dihe-in -63.18, -27.15 -46.65, -49.09 APE12-dist-in 13.476 APE11-dist-in 12.358 APE10-dist-in 7.297 APE9-dist-in 3.221 None TPO160 TPO160 XRAY 2.43 0.203 0.251 A 302 262 29 0 0 0 [[4, 286]] 1.0 6sg4 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6SG4C 29 295 298.0 No_ligand No_ligand Inactive DFGin 6.267 16.249 BLAminus -137.43, 175.83 54.02, 83.17 -94.69, 27.17 280.38, 64.22 -59.95, -51.33 out-out out 13.669 Saltbr-out 13.339 HRD-in -70.61, -65.73 80.25, 9.94 out-in-in SNCoii in-in ActLoopNT-in 3.113 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.33, -55.22 APE9-dihe-na -67.84, 151.02 APE8-dihe-in -58.58, 141.84 APE8-rot-in 311.32 APE67-dihe-in -64.58, -30.99 -51.04, -45.77 APE12-dist-in 13.48 APE11-dist-in 12.252 APE10-dist-in 6.83 APE9-dist-in 3.537 None TPO160 TPO160 XRAY 2.43 0.203 0.251 C 302 261 31 0 0 0 [[4, 286]] 1.0 6sg4 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H24A 1 293 298.0 No_ligand No_ligand Inactive DFGin 6.37 15.441 BLAminus -149.05, 176.13 58.55, 82.71 -98.93, 22.4 284.12, 70.53 -57.88, -40.84 in-out in 8.905 Saltbr-out 3.678 HRD-in -79.24, -45.57 66.77, 15.64 out-in-in SNCoii in-in ActLoopNT-in 2.986 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.68, 132.36 APE9-dihe-na 80.91, 130.55 APE8-dihe-in -56.75, 124.45 APE8-rot-in 291.68 APE67-dihe-in -59.21, -22.16 -34.29, -51.02 APE12-dist-in 13.068 APE11-dist-in 9.844 APE10-dist-in 7.943 APE9-dist-in 3.323 None TPO160 TPO160 XRAY 2.5 0.212 0.27 A 303 293 0 0 0 0 [[4, 286]] 1.0 1h24 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOPA 1 297 298.0 1RO:60301 Type1 Inactive DFGin 6.723 14.906 BLAminus -142.23, 176.95 53.72, 81.49 -94.48, 24.24 283.28, 65.78 -63.26, -27.47 in-in in 8.449 Saltbr-in 2.822 HRD-in -80.96, -51.6 68.18, 9.66 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 70.66, 113.36 APE9-dihe-na 74.68, 127.54 APE8-dihe-in -59.54, 139.46 APE8-rot-out 59.13 APE67-dihe-in -58.69, -27.51 -46.09, -46.99 APE12-dist-in 13.181 APE11-dist-in 11.447 APE10-dist-in 7.369 APE9-dist-in 3.234 Q131E TPO160 TPO160 XRAY 1.99 0.217 0.241 A 300 295 2 0 0 0 [[4, 286]] 1.0 4eop CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOPC 1 296 298.0 1RO:60301 Type1 Inactive DFGin 6.659 14.989 BLAminus -141.59, -178.41 53.15, 82.16 -98.68, 23.27 279.66, 67.46 -60.45, -30.01 in-in in 8.475 Saltbr-in 2.577 HRD-in -79.11, -56.1 69.98, 13.7 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.71, 145.25 APE9-dihe-na 75.85, 128.83 APE8-dihe-in -51.66, 132.74 APE8-rot-out 165.33 APE67-dihe-in -57.08, -27.57 -43.54, -49.82 APE12-dist-in 13.046 APE11-dist-in 9.735 APE10-dist-in 7.394 APE9-dist-in 3.113 Q131E TPO160 TPO160 XRAY 1.99 0.217 0.241 C 300 296 0 0 0 0 [[4, 286]] 1.0 4eop CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOIC 1 296 298.0 1RO:60301 Type1 Inactive DFGin 6.532 15.052 BLAminus -147.54, 173.29 55.92, 74.44 -88.6, 22.51 283.95, 67.62 -63.63, -26.66 in-in in 8.392 Saltbr-in 2.597 HRD-in -75.18, -52.68 66.93, 12.44 in-in-out SNCiio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -61.02, 154.87 APE9-dihe-na 73.94, 127.83 APE8-dihe-in -53.4, 131.61 APE8-rot-out 162.43 APE67-dihe-in -60.65, -19.15 -42.11, -50.1 APE12-dist-in 12.995 APE11-dist-in 9.392 APE10-dist-in 7.138 APE9-dist-in 3.207 K89D,Q131E TPO160 TPO160 XRAY 2.0 0.215 0.234 C 299 296 0 0 0 0 [[4, 286]] 1.0 4eoi CMGC_CDK2_HUMAN CMGC 6.9e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PKDA 1 296 298.0 UCN:60410 Type1 Inactive DFGin 6.575 15.387 BLAminus -133.85, 171.83 54.3, 84.1 -93.29, 24.7 280.02, 73.48 -58.68, -37.61 in-out in 8.802 Saltbr-out 3.66 HRD-in -78.55, -55.12 71.6, 20.95 out-in-in SNCoii in-in ActLoopNT-in 3.033 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.48, 136.15 APE9-dihe-na 78.94, 132.36 APE8-dihe-in -52.7, 137.01 APE8-rot-in 296.12 APE67-dihe-in -63.8, -19.34 -42.25, -50.85 APE12-dist-in 13.145 APE11-dist-in 10.217 APE10-dist-in 7.647 APE9-dist-in 3.38 None TPO160 TPO160 XRAY 2.3 0.218 0.268 A 297 296 0 0 0 0 [[4, 286]] 1.0 1pkd CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5LMKC 1 296 298.0 6ZK:60301 Type1 Inactive DFGin 6.705 15.05 BLAminus -133.26, 168.47 55.4, 88.46 -97.71, 24.83 283.38, 67.26 -61.17, -33.57 in-in in 8.381 Saltbr-in 2.721 HRD-in -79.79, -56.45 69.59, 15.54 in-in-out SNCiio in-out ActLoopNT-in 3.041 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.62, 152.55 APE9-dihe-na 64.49, 124.67 APE8-dihe-in -64.32, 149.59 APE8-rot-out 199.23 APE67-dihe-in -63.12, -14.1 -44.88, -52.53 APE12-dist-in 12.806 APE11-dist-in 10.06 APE10-dist-in 6.819 APE9-dist-in 3.354 None TPO160 TPO160 XRAY 2.4 0.213 0.249 C 297 265 31 0 0 0 [[4, 286]] 1.0 5lmk CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EORA 1 297 298.0 4SP:60301 Type1 Inactive DFGin 6.882 15.033 BLAminus -134.35, 175.73 52.6, 78.13 -90.64, 21.49 277.96, 74.78 -65.84, -25.49 in-out in 8.397 Saltbr-out 4.415 HRD-in -78.57, -52.47 67.64, 16.68 out-in-in SNCoii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -52.36, 151.62 APE9-dihe-na 75.68, 126.45 APE8-dihe-in -53.52, 134.61 APE8-rot-in 299.42 APE67-dihe-in -64.87, -24.77 -45.32, -44.73 APE12-dist-in 13.316 APE11-dist-in 9.486 APE10-dist-in 7.268 APE9-dist-in 3.338 None TPO160 TPO160 XRAY 2.2 0.222 0.245 A 298 293 4 0 0 0 [[4, 286]] 1.0 4eor CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EORC 1 294 298.0 4SP:60301 Type1 Inactive DFGin 6.781 14.95 BLAminus -138.63, 178.48 45.83, 76.13 -84.97, 25.42 283.82, 70.0 -63.08, -30.05 in-in in 8.545 Saltbr-in 2.705 HRD-in -80.46, -52.24 65.94, 14.93 in-in-out SNCiio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.75, 149.39 APE9-dihe-na 67.36, 128.22 APE8-dihe-in -66.22, 148.97 APE8-rot-out 182.23 APE67-dihe-in -56.76, -22.19 -48.62, -53.23 APE12-dist-in 12.889 APE11-dist-in 9.84 APE10-dist-in 7.025 APE9-dist-in 3.22 None TPO160 TPO160 XRAY 2.2 0.222 0.245 C 298 270 24 0 0 0 [[4, 286]] 1.0 4eor CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1FVVA 1 298 298.0 107:501 Type1 Inactive DFGin 6.658 14.901 BLAminus -137.65, 171.94 57.98, 81.02 -95.75, 36.92 284.57, 57.51 -69.65, -41.19 in-in in 8.048 Saltbr-in 2.87 HRD-in -77.21, -53.67 74.56, -7.57 in-in-out SNCiio in-out ActLoopNT-in 2.711 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.03, -46.72 APE9-dihe-na -50.79, 166.23 APE8-dihe-in -64.52, 158.74 APE8-rot-out 198.27 APE67-dihe-in -53.47, -26.59 -84.97, -53.54 APE12-dist-in 13.444 APE11-dist-in 12.405 APE10-dist-in 7.041 APE9-dist-in 4.494 None None None XRAY 2.8 0.21 0.26 A 298 298 0 0 0 0 [[4, 286]] 1.0 1fvv CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1FVVC 1 298 298.0 107:601 Type1 Inactive DFGin 6.361 14.899 BLAminus -137.03, 174.12 49.53, 89.09 -101.6, 27.15 286.0, 65.52 -55.32, -31.13 in-in in 8.256 Saltbr-in 2.958 HRD-in -78.2, -48.22 68.63, -7.2 in-in-out SNCiio in-out ActLoopNT-in 2.801 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiii APE10-dihe-na -115.1, -27.85 APE9-dihe-na -49.77, 137.89 APE8-dihe-in -57.38, 118.15 APE8-rot-out 181.94 APE67-dihe-in -55.57, -48.11 -37.79, -50.26 APE12-dist-out 14.006 APE11-dist-in 12.366 APE10-dist-in 7.566 APE9-dist-in 4.312 None None None XRAY 2.8 0.21 0.26 C 298 298 0 0 0 0 [[4, 286]] 1.0 1fvv CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C5NA 1 296 298.0 CK8:1297 Type1 Inactive DFGin 6.462 15.333 BLAminus -134.71, 179.52 48.73, 86.34 -97.55, 25.19 275.89, 67.63 -63.89, -28.59 in-in in 8.543 Saltbr-in 2.861 HRD-in -83.74, -45.86 67.31, -5.85 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -100.4, 27.23 APE9-dihe-na -97.0, -7.31 APE8-dihe-out 101.7, 140.58 APE8-rot-out 225.76 APE67-dihe-in -62.0, -24.64 -95.08, -50.02 APE12-dist-out 14.274 APE11-dist-in 11.452 APE10-dist-out 8.969 APE9-dist-in 5.21 None None None XRAY 2.1 0.178 0.259 A 298 296 0 0 0 0 [[4, 286]] 1.0 2c5n CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C5NC 1 297 298.0 CK8:1298 Type1 Inactive DFGin 6.63 15.437 BLAminus -141.11, 171.58 67.92, 76.41 -96.67, 28.48 283.19, 65.37 -68.12, -31.46 in-in in 8.555 Saltbr-in 2.627 HRD-in -73.82, -54.83 87.12, -13.53 in-in-out SNCiio in-out ActLoopNT-in 2.951 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -121.38, 99.53 APE9-dihe-na -160.5, -177.06 APE8-dihe-in -68.95, 135.12 APE8-rot-out 74.74 APE67-dihe-in -60.97, -29.13 -104.2, -8.66 APE12-dist-out 16.291 APE11-dist-in 10.261 APE10-dist-out 12.525 APE9-dist-out 9.045 None None None XRAY 2.1 0.178 0.259 C 298 297 0 0 0 0 [[4, 286]] 1.0 2c5n CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C5OA 1 296 298.0 CK2:1297 Type1 Inactive DFGin 6.494 15.29 BLAminus -137.74, 173.02 58.56, 80.78 -92.88, 19.82 283.21, 65.89 -51.26, -36.47 in-in in 8.62 Saltbr-in 3.023 HRD-in -83.52, -43.57 76.97, -18.17 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -99.47, 35.52 APE9-dihe-na -88.97, 170.31 APE8-dihe-in -57.41, 159.51 APE8-rot-out 226.24 APE67-dihe-in -53.95, -30.16 -94.63, -49.34 APE12-dist-out 14.686 APE11-dist-in 11.359 APE10-dist-out 9.793 APE9-dist-in 5.599 None None None XRAY 2.1 0.197 0.256 A 298 296 0 0 0 0 [[4, 286]] 1.0 2c5o CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C5OC 1 297 298.0 CK2:1298 Type1 Inactive DFGin 6.476 15.429 BLAminus -144.63, 177.97 57.45, 72.75 -89.52, 20.98 280.55, 69.4 -66.45, -25.41 in-in in 8.538 Saltbr-in 3.095 HRD-in -84.92, -44.81 82.92, -18.25 in-in-out SNCiio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -95.84, 39.31 APE9-dihe-na -90.01, 169.5 APE8-dihe-in -56.49, 156.39 APE8-rot-out 222.88 APE67-dihe-in -60.8, -32.24 -97.54, -42.65 APE12-dist-out 14.878 APE11-dist-in 11.424 APE10-dist-out 9.966 APE9-dist-in 5.682 None None None XRAY 2.1 0.197 0.256 C 298 297 0 0 0 0 [[4, 286]] 1.0 2c5o CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C5VA 1 296 298.0 CK4:1297 Type1 Inactive DFGin 6.4 15.573 BLAminus -152.6, 173.72 50.46, 81.89 -96.59, 19.88 274.06, 74.93 -61.32, -20.24 in-in in 8.811 Saltbr-in 2.869 HRD-in -75.99, -60.23 91.66, -18.06 in-in-out SNCiio in-out ActLoopNT-in 2.783 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -109.47, 18.26 APE9-dihe-na -77.73, -92.42 APE8-dihe-in -159.97, 141.7 APE8-rot-out 178.35 APE67-dihe-in -63.79, -32.5 -86.3, -47.27 APE12-dist-out 14.533 APE11-dist-in 11.488 APE10-dist-out 10.2 APE9-dist-out 6.251 None None None XRAY 2.9 0.175 0.282 A 298 296 0 0 0 0 [[4, 286]] 1.0 2c5v CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C5VC 1 296 298.0 CK4:1297 Type1 Inactive DFGin 6.33 15.522 BLAminus -154.23, 176.87 55.11, 76.96 -96.71, 24.34 275.08, 71.53 -59.6, -22.02 in-in in 8.621 Saltbr-in 3.132 HRD-in -61.51, -55.66 92.96, -22.41 in-in-out SNCiio in-out ActLoopNT-in 2.986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -115.04, 15.2 APE9-dihe-na -65.4, -115.45 APE8-dihe-in -142.09, 152.22 APE8-rot-out 184.7 APE67-dihe-in -64.96, -41.68 -88.36, -39.06 APE12-dist-out 14.221 APE11-dist-in 10.918 APE10-dist-out 10.336 APE9-dist-out 6.492 None None None XRAY 2.9 0.175 0.282 C 298 296 0 0 0 0 [[4, 286]] 1.0 2c5v CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C5XA 1 296 298.0 MTW:1297 Type1 Inactive DFGin 6.456 15.49 BLAminus -147.14, 173.63 64.88, 81.13 -99.82, 31.9 280.01, 44.97 -72.1, -29.12 in-in in 8.351 Saltbr-in 3.421 HRD-in -95.4, -39.54 63.25, -15.18 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oioi APE10-dihe-na -84.91, 67.81 APE9-dihe-na -125.9, -36.28 APE8-dihe-out 122.49, 156.35 APE8-rot-out 176.62 APE67-dihe-out 57.5, -47.85 -96.74, -115.33 APE12-dist-out 14.12 APE11-dist-in 11.374 APE10-dist-out 9.051 APE9-dist-in 5.854 None None None XRAY 2.9 0.203 0.264 A 298 296 0 0 0 0 [[4, 286]] 1.0 2c5x CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C5XC 1 296 298.0 MTW:1297 Type1 Inactive DFGin 6.478 15.536 BLAminus -137.8, 171.4 74.5, 81.98 -98.98, 18.7 276.64, 65.26 -59.32, -18.19 in-in in 8.872 Saltbr-in 3.325 HRD-in -99.79, -42.03 69.9, -20.79 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -106.41, 92.79 APE9-dihe-na -94.18, -148.42 APE8-dihe-in -127.45, 167.08 APE8-rot-out 106.98 APE67-dihe-in -21.73, -45.61 -109.0, -46.95 APE12-dist-out 14.979 APE11-dist-in 9.273 APE10-dist-out 11.28 APE9-dist-out 6.942 None None None XRAY 2.9 0.203 0.264 C 298 296 0 0 0 0 [[4, 286]] 1.0 2c5x CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2I40A 1 297 298.0 BLZ:301 Type1 Inactive DFGin 6.501 15.32 BLAminus -136.92, 178.32 54.65, 74.51 -89.47, 33.14 288.96, 69.44 -65.33, -27.4 in-in in 8.719 Saltbr-in 2.817 HRD-in -76.77, -57.06 80.86, -11.7 in-in-out SNCiio in-out ActLoopNT-in 2.789 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnii APE10-dihe-na 999.0, -92.23 APE9-dihe-na -60.69, 145.56 APE8-dihe-in -55.35, 148.14 APE8-rot-out 189.36 APE67-dihe-in -50.54, -27.99 -55.95, -51.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.458 APE9-dist-in 4.135 None None None XRAY 2.8 0.195 0.222 A 298 291 6 0 0 3 [[4, 286]] 1.0 2i40 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2I40C 1 296 298.0 BLZ:401 Type1 Inactive DFGin 6.5 15.684 BLAminus -135.33, 178.43 51.55, 77.51 -89.62, 25.76 284.58, 71.55 -62.03, -32.72 in-in in 8.887 Saltbr-in 2.947 HRD-in -75.92, -56.81 84.43, -19.08 in-in-out SNCiio in-out ActLoopNT-in 2.786 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -117.69, -26.4 APE9-dihe-na -42.35, 127.37 APE8-dihe-in -54.04, 136.23 APE8-rot-in 299.61 APE67-dihe-in -58.47, -31.19 -61.46, -43.46 APE12-dist-out 14.259 APE11-dist-in 12.034 APE10-dist-out 8.018 APE9-dist-in 4.557 None None None XRAY 2.8 0.195 0.222 C 298 296 0 0 0 0 [[4, 286]] 1.0 2i40 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UUEA 1 296 298.0 MTZ:1297 Type1 Inactive DFGin 6.668 15.552 BLAminus -136.51, -179.65 55.04, 76.1 -99.46, 27.06 276.81, 66.03 -71.99, -20.9 in-in in 8.424 Saltbr-in 2.99 HRD-in -83.38, -47.65 80.14, -16.01 in-in-out SNCiio in-out ActLoopNT-in 2.883 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -101.45, 44.37 APE9-dihe-na -136.17, 15.14 APE8-dihe-out 83.13, 148.34 APE8-rot-out 226.35 APE67-dihe-in -65.4, -22.8 -105.43, -48.8 APE12-dist-out 14.683 APE11-dist-in 11.62 APE10-dist-out 9.277 APE9-dist-in 5.446 None None None XRAY 2.06 0.197 0.244 A 298 296 0 0 0 0 [[4, 286]] 1.0 2uue CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UUEC 1 297 298.0 MTZ:1298 Type1 Inactive DFGin 6.549 15.634 BLAminus -139.6, 174.69 63.14, 72.39 -91.13, 24.55 277.59, 65.12 -71.23, -27.72 in-in in 8.585 Saltbr-in 2.887 HRD-in -84.99, -51.24 81.34, -14.94 in-in-out SNCiio in-out ActLoopNT-in 2.846 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioi APE10-dihe-na -103.79, 100.15 APE9-dihe-na -148.09, 37.68 APE8-dihe-out 71.12, 132.14 APE8-rot-in 268.33 APE67-dihe-in -63.15, -29.14 -103.73, -38.08 APE12-dist-out 14.954 APE11-dist-in 10.215 APE10-dist-out 10.31 APE9-dist-in 5.642 None None None XRAY 2.06 0.197 0.244 C 298 297 0 0 0 0 [[4, 286]] 1.0 2uue CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UZBA 1 296 298.0 C75:1297 Type1 Inactive DFGin 6.471 15.057 BLAminus -129.19, -178.51 56.65, 88.46 -107.29, 15.28 270.35, 76.74 -60.46, -29.47 in-in in 8.535 Saltbr-in 2.518 HRD-in -73.89, -54.05 70.29, 11.12 in-in-out SNCiio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iioi APE10-dihe-na -148.51, 138.56 APE9-dihe-na 70.2, 129.64 APE8-dihe-out -36.9, -63.1 APE8-rot-in 288.05 APE67-dihe-out -70.04, -6.32 176.95, -44.48 APE12-dist-in 13.304 APE11-dist-in 10.692 APE10-dist-out 8.012 APE9-dist-in 3.283 None TPO160 TPO160 XRAY 2.7 0.204 0.265 A 298 296 0 0 0 0 [[4, 286]] 1.0 2uzb CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UZBC 1 296 298.0 C75:1297 Type1 Inactive DFGin 6.522 14.908 BLAminus -140.34, 177.92 49.12, 95.7 -109.59, 12.68 278.13, 73.33 -52.09, -28.0 in-in in 8.549 Saltbr-in 2.283 HRD-in -73.05, -55.02 77.4, -9.35 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -142.42, 147.08 APE9-dihe-na 62.72, 130.96 APE8-dihe-in -51.48, 137.46 APE8-rot-in 296.88 APE67-dihe-in -63.1, -14.88 -43.44, -51.26 APE12-dist-in 13.444 APE11-dist-in 10.901 APE10-dist-out 8.158 APE9-dist-in 3.288 None TPO160 TPO160 XRAY 2.7 0.204 0.265 C 298 296 0 0 0 0 [[4, 286]] 1.0 2uzb CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WEVA 1 296 298.0 CK7:1297 Type1 Inactive DFGin 6.544 15.198 BLAminus -137.41, 168.51 60.01, 89.74 -102.99, 17.97 279.57, 71.74 -57.11, -35.26 in-in in 8.511 Saltbr-in 2.846 HRD-in -69.59, -48.84 79.69, -15.41 in-in-out SNCiio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -105.15, 11.47 APE9-dihe-na -89.16, -44.89 APE8-dihe-out 143.37, 137.63 APE8-rot-out 228.7 APE67-dihe-in -61.17, -29.84 -80.46, -51.97 APE12-dist-out 14.099 APE11-dist-in 11.434 APE10-dist-out 8.181 APE9-dist-in 5.084 None None None XRAY 2.3 0.19 0.243 A 298 296 0 0 0 0 [[4, 286]] 1.0 2wev CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WEVC 1 297 298.0 CK7:1298 Type1 Inactive DFGin 6.55 15.195 BLAminus -133.81, 172.14 61.33, 84.34 -99.44, 26.27 283.39, 69.9 -63.87, -37.78 in-in in 8.143 Saltbr-in 2.433 HRD-in -72.76, -51.33 81.44, -12.38 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -100.11, 130.34 APE9-dihe-na -149.09, 144.26 APE8-dihe-in -80.58, 128.5 APE8-rot-out 70.59 APE67-dihe-in -55.73, -32.73 -97.58, -7.58 APE12-dist-out 14.848 APE11-dist-in 9.707 APE10-dist-out 12.361 APE9-dist-out 9.181 None None None XRAY 2.3 0.19 0.243 C 298 297 0 0 0 0 [[4, 286]] 1.0 2wev CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2X1NA 1 296 298.0 X1N:1297 Type1 Inactive DFGin 6.424 15.518 BLAminus -128.87, 173.75 57.37, 81.12 -96.89, 24.14 281.65, 61.56 -56.06, -34.95 in-in in 8.616 Saltbr-in 2.789 HRD-in -83.76, -48.79 78.25, -11.35 in-in-out SNCiio in-out ActLoopNT-in 2.777 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -113.97, 28.15 APE9-dihe-na -117.45, 36.28 APE8-dihe-out 70.98, 159.25 APE8-rot-out 222.34 APE67-dihe-in -54.58, -36.43 -112.0, -52.59 APE12-dist-out 14.527 APE11-dist-in 11.495 APE10-dist-out 8.41 APE9-dist-in 5.364 None None None XRAY 2.75 0.201 0.255 A 298 296 0 0 0 0 [[4, 286]] 1.0 2x1n CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2X1NC 1 297 298.0 X1N:1298 Type1 Inactive DFGin 6.519 15.581 BLAminus -140.69, 175.53 56.15, 80.34 -98.54, 27.35 281.18, 64.02 -63.04, -37.34 in-in in 8.557 Saltbr-in 2.659 HRD-in -84.17, -48.0 72.08, -11.97 in-in-out SNCiio in-out ActLoopNT-in 2.842 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioi APE10-dihe-na 171.44, 21.19 APE9-dihe-na -101.12, -165.53 APE8-dihe-out -79.77, -47.71 APE8-rot-out 65.2 APE67-dihe-out 41.1, -61.77 83.85, -152.78 APE12-dist-in 13.959 APE11-dist-in 11.515 APE10-dist-out 8.051 APE9-dist-in 5.584 None None None XRAY 2.75 0.201 0.255 C 298 297 0 0 0 0 [[4, 286]] 1.0 2x1n CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3EJ1A 1 298 298.0 5BP:299 Type1 Inactive DFGin 6.529 15.014 BLAminus -120.39, -170.6 34.57, 102.84 -117.66, 33.2 277.9, 72.92 -74.44, -26.93 in-in in 8.423 Saltbr-in 3.014 HRD-in -80.36, -45.99 78.08, -25.82 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -76.39, -8.58 APE9-dihe-na -57.46, 149.87 APE8-dihe-in -50.94, 143.15 APE8-rot-out 178.4 APE67-dihe-in -71.26, -28.12 -76.42, -41.79 APE12-dist-in 13.499 APE11-dist-in 11.112 APE10-dist-out 8.04 APE9-dist-in 5.228 None None None XRAY 3.22 0.221 0.259 A 298 295 3 0 0 0 [[4, 286]] 1.0 3ej1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3EJ1C 1 297 298.0 5BP:299 Type1 Inactive DFGin 6.369 15.042 BLAminus -144.37, -176.79 46.4, 77.05 -94.51, 19.83 282.26, 67.49 -58.35, -21.4 in-in in 8.458 Saltbr-in 3.139 HRD-in -76.98, -52.36 75.48, -9.6 in-in-out SNCiio in-out ActLoopNT-in 2.936 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -84.78, -32.93 APE9-dihe-na -40.13, 131.59 APE8-dihe-in -49.27, 137.46 APE8-rot-out 170.58 APE67-dihe-in -60.52, -32.57 -69.36, -45.07 APE12-dist-out 14.918 APE11-dist-in 11.897 APE10-dist-out 8.109 APE9-dist-in 4.553 None None None XRAY 3.22 0.221 0.259 C 298 294 3 0 0 0 [[4, 286]] 1.0 3ej1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3EOCC 1 296 298.0 T2A:501 Type1 Inactive DFGin 6.611 15.546 BLAminus -134.65, 174.05 57.27, 76.83 -94.67, 37.28 281.99, 69.27 -70.56, -37.12 in-in in 8.56 Saltbr-in 2.849 HRD-in -83.74, -52.0 74.56, -5.56 in-in-out SNCiio in-out ActLoopNT-in 2.773 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -115.04, 10.56 APE9-dihe-na -74.14, 148.71 APE8-dihe-in -60.81, 135.44 APE8-rot-in 317.1 APE67-dihe-in -54.07, -37.93 -65.67, -45.23 APE12-dist-out 14.196 APE11-dist-in 11.582 APE10-dist-in 7.941 APE9-dist-in 4.519 None None None XRAY 3.2 0.216 0.238 C 298 293 3 0 0 0 [[4, 286]] 1.0 3eoc CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3TIYA 2 298 298.0 TIY:311 Type1 Inactive DFGin 8.87 14.878 BLAminus -126.04, 167.5 54.82, 63.4 -71.45, -6.97 283.55, 59.96 76.63, -119.91 out-out out 15.568 Saltbr-out 15.476 HRD-in -82.34, -63.91 78.23, -16.74 out-out-out SNCooo out-out ActLoopNT-out 5.998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -95.26, 112.87 APE9-dihe-na -58.02, 134.56 APE8-dihe-in -84.54, 123.93 APE8-rot-out 191.63 APE67-dihe-in -58.87, -29.31 -96.47, -4.21 APE12-dist-out 22.087 APE11-dist-out 17.696 APE10-dist-out 20.214 APE9-dist-out 10.946 None None None XRAY 1.84 0.184 0.224 A 298 293 4 0 0 0 [[4, 286]] 1.0 3tiy CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FX3A 1 298 298.0 60K:301 Type1 Inactive DFGin 6.197 15.103 BLAminus -126.13, 178.6 49.1, 93.46 -105.8, 30.24 276.32, 71.06 -61.87, -44.99 in-in in 8.424 Saltbr-in 2.924 HRD-in -80.6, -54.87 72.29, 6.25 in-in-out SNCiio in-out ActLoopNT-in 2.879 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -130.98, 158.93 APE9-dihe-na -62.78, 151.96 APE8-dihe-in -53.23, 142.13 APE8-rot-out 179.6 APE67-dihe-in -43.78, -29.12 -33.97, -54.96 APE12-dist-in 10.58 APE11-dist-out 5.7 APE10-dist-out 8.894 APE9-dist-in 3.726 None None None XRAY 2.75 0.192 0.24 A 298 298 0 0 0 0 [[4, 286]] 1.0 4fx3 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FX3C 1 298 298.0 60K:301 Type1 Inactive DFGin 6.172 15.026 BLAminus -134.21, -178.78 44.13, 89.74 -104.79, 28.66 280.48, 70.83 -64.33, -46.69 in-in in 8.486 Saltbr-in 3.094 HRD-in -72.23, -48.72 69.82, -6.08 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -143.68, -175.34 APE9-dihe-na -66.47, 158.06 APE8-dihe-in -51.29, 145.45 APE8-rot-in 314.05 APE67-dihe-in -46.63, -39.05 -40.33, -50.3 APE12-dist-in 11.252 APE11-dist-out 6.439 APE10-dist-out 8.445 APE9-dist-in 3.665 None None None XRAY 2.75 0.192 0.24 C 298 298 0 0 0 0 [[4, 286]] 1.0 4fx3 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8CURA 1 296 298.0 OW6:301 Type1 Inactive DFGin 9.773 15.723 BLAminus -137.32, 165.63 62.71, 70.1 -84.84, 10.34 282.1, 70.32 55.44, 35.34 out-out out 16.699 Saltbr-out 16.127 HRD-in -88.63, -55.17 83.16, -14.53 out-out-out SNCooo out-out ActLoopNT-out 10.118 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 130.72 APE9-dihe-na -139.45, 145.22 APE8-dihe-in -77.77, 135.94 APE8-rot-out 177.91 APE67-dihe-in -60.81, -26.31 -95.02, 0.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.855 APE9-dist-out 10.893 None None None XRAY 2.2 0.201 0.267 A 298 274 22 0 0 11 [[4, 286]] 1.0 8cur CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8H6PA 1 297 298.0 WZU:60301 Type1 Inactive DFGin 6.832 15.812 BLAminus -138.9, 169.91 56.25, 91.6 -100.72, 19.84 277.25, 72.88 -67.38, -28.56 in-in in 9.187 Saltbr-in 2.866 HRD-in -76.72, -60.89 80.19, -5.93 in-in-out SNCiio in-out ActLoopNT-in 2.772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.82, 146.29 APE9-dihe-na 73.34, 130.66 APE8-dihe-in -67.97, 146.16 APE8-rot-out 97.01 APE67-dihe-in -66.71, -23.48 -48.91, -47.0 APE12-dist-in 12.739 APE11-dist-in 9.978 APE10-dist-in 7.097 APE9-dist-in 3.143 None TPO160 TPO160 XRAY 2.44 0.222 0.292 A 298 297 0 0 0 0 [[4, 286]] 1.0 8h6p CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3DDQC 1 297 298.0 RRC:60299 Type1 Inactive DFGin 6.683 15.237 BLAminus -135.03, 174.73 51.22, 81.22 -92.28, 22.06 280.24, 71.12 -61.17, -31.8 in-in in 8.802 Saltbr-in 2.629 HRD-in -78.79, -55.27 70.81, 11.54 in-in-out SNCiio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.5, 150.72 APE9-dihe-na 67.57, 123.07 APE8-dihe-in -58.23, 146.27 APE8-rot-out 184.04 APE67-dihe-in -63.49, -21.74 -43.48, -49.11 APE12-dist-in 12.765 APE11-dist-in 9.988 APE10-dist-in 6.863 APE9-dist-in 3.244 None TPO160 TPO160 XRAY 1.8 0.196 0.229 C 299 266 31 0 0 0 [[4, 286]] 1.0 3ddq CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3DOGA 1 298 298.0 NNN:60299 Type1 Inactive DFGin 6.622 15.124 BLAminus -123.83, 171.95 56.41, 94.47 -105.53, 13.92 276.45, 71.26 -61.4, -24.91 in-in in 8.343 Saltbr-in 2.572 HRD-in -74.01, -59.72 75.02, 13.59 in-in-out SNCiio in-out ActLoopNT-in 2.977 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -158.74, 129.37 APE9-dihe-na 67.46, 135.39 APE8-dihe-in -55.08, 134.55 APE8-rot-in 285.3 APE67-dihe-in -61.78, -16.0 -48.46, -43.14 APE12-dist-in 12.737 APE11-dist-in 9.742 APE10-dist-out 8.219 APE9-dist-in 3.151 None TPO160 TPO160 XRAY 2.7 0.197 0.248 A 299 297 1 0 0 0 [[4, 286]] 1.0 3dog CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3DOGC 1 297 298.0 NNN:60299 Type1 Inactive DFGin 6.592 14.999 BLAminus -128.02, 179.32 44.45, 89.67 -97.23, 22.43 280.59, 63.22 -60.28, -33.83 in-in in 8.292 Saltbr-in 2.674 HRD-in -85.15, -49.99 70.0, 6.47 in-in-out SNCiio in-out ActLoopNT-in 2.917 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.97, -49.47 APE9-dihe-na -120.71, 146.21 APE8-dihe-in -55.12, 140.65 APE8-rot-out 83.77 APE67-dihe-in -60.72, -21.94 -37.84, -55.18 APE12-dist-in 12.779 APE11-dist-in 10.306 APE10-dist-in 7.459 APE9-dist-in 3.326 None TPO160 TPO160 XRAY 2.7 0.197 0.248 C 299 267 30 0 0 0 [[4, 286]] 1.0 3dog CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6JGMA 1 298 298.0 AQG:900 Type1 Inactive DFGin 9.549 15.591 BLAminus -111.97, 138.12 84.08, 77.16 -91.54, 40.25 302.73, 39.97 -125.42, 999.0 out-out out 14.929 Saltbr-out 13.825 HRD-in -91.45, -57.13 77.4, -6.2 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 113.03 APE9-dihe-na -69.43, 143.39 APE8-dihe-in -89.14, 138.92 APE8-rot-in 298.11 APE67-dihe-in -55.83, -28.78 -108.79, -2.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.684 None None None XRAY 2.3 0.218 0.29 A 299 279 19 0 0 15 [[4, 286]] 1.0 6jgm CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8B54A 1 294 298.0 P2V:301 Type1 Inactive DFGin 6.514 15.247 BLAminus -128.12, 170.62 59.1, 85.13 -100.08, 22.73 286.24, 67.7 -63.02, -30.99 in-in in 8.487 Saltbr-in 2.815 HRD-in -82.86, -54.52 68.83, 22.28 in-in-out SNCiio in-out ActLoopNT-in 3.055 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -99.69, 158.44 APE9-dihe-na 80.04, 135.87 APE8-dihe-in -60.84, 136.8 APE8-rot-out 36.15 APE67-dihe-in -51.66, -27.71 -44.78, -57.24 APE12-dist-in 13.431 APE11-dist-in 12.01 APE10-dist-in 7.248 APE9-dist-in 3.365 None TPO160 TPO160 XRAY 2.6 0.234 0.287 A 299 292 2 0 0 0 [[4, 286]] 1.0 8b54 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4NJ3A 1 298 298.0 2KD:60301 Type1 Inactive DFGin 9.341 15.594 BLAminus -130.79, 172.52 45.12, 81.35 -88.92, 3.27 284.6, 64.16 63.2, 34.26 out-out out 16.126 Saltbr-out 15.981 HRD-in -77.06, -53.47 83.75, -19.23 out-out-out SNCooo out-out ActLoopNT-out 10.694 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -66.4, 122.78 APE9-dihe-na -80.52, 121.26 APE8-dihe-in -75.92, 125.78 APE8-rot-in 291.48 APE67-dihe-in -50.09, -30.36 -105.53, -5.27 APE12-dist-none 999.0 APE11-dist-out 16.997 APE10-dist-out 20.365 APE9-dist-out 10.989 None None CSD177 XRAY 1.848 0.184 0.231 A 299 281 17 0 0 11 [[4, 286]] 1.0 4nj3 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOSA 1 297 298.0 1RO:60301 Type1 Inactive DFGin 6.679 14.917 BLAminus -141.96, 173.39 61.75, 76.99 -94.88, 23.86 287.29, 67.82 -62.13, -29.58 in-in in 8.579 Saltbr-in 2.677 HRD-in -71.72, -54.24 68.99, 15.84 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -51.01, 139.09 APE9-dihe-na 90.64, 134.44 APE8-dihe-in -63.39, 144.28 APE8-rot-out 31.42 APE67-dihe-in -59.13, -27.23 -51.22, -47.22 APE12-dist-in 13.101 APE11-dist-in 9.197 APE10-dist-in 7.565 APE9-dist-in 3.512 None TPO160 TPO160 XRAY 2.57 0.232 0.274 A 300 294 3 0 0 0 [[4, 286]] 1.0 4eos CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOSC 1 296 298.0 1RO:60301 Type1 Inactive DFGin 6.674 15.293 BLAminus -142.14, 172.73 60.66, 72.59 -88.34, 30.63 286.6, 69.5 -72.66, -28.9 in-in in 8.394 Saltbr-in 2.646 HRD-in -72.54, -50.67 68.34, 9.35 in-in-out SNCiio in-out ActLoopNT-in 2.911 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.28, 156.88 APE9-dihe-na 66.24, 127.49 APE8-dihe-in -57.72, 139.89 APE8-rot-out 169.26 APE67-dihe-in -54.97, -19.05 -46.71, -53.73 APE12-dist-in 13.153 APE11-dist-in 10.99 APE10-dist-in 7.365 APE9-dist-in 3.239 None TPO160 TPO160 XRAY 2.57 0.232 0.274 C 300 296 0 0 0 0 [[4, 286]] 1.0 4eos CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H1QA 1 296 298.0 2A6:61298 Type1 Inactive DFGin 6.512 14.862 BLAminus -132.06, 176.21 56.25, 86.82 -91.89, 16.14 280.93, 75.89 -52.78, -45.0 in-out in 8.598 Saltbr-out 4.199 HRD-in -78.2, -44.47 62.96, 33.71 out-in-in SNCoii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.52, 142.46 APE9-dihe-na 75.73, 142.33 APE8-dihe-in -61.63, 140.37 APE8-rot-in 280.51 APE67-dihe-in -59.24, -24.16 -43.09, -55.2 APE12-dist-in 13.017 APE11-dist-in 10.083 APE10-dist-in 7.927 APE9-dist-in 3.398 None TPO160 TPO160 XRAY 2.5 0.238 0.332 A 303 296 0 0 0 0 [[4, 286]] 1.0 1h1q CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7MKXA 1 296 298.0 ZGY:60301 Type1 Inactive DFGin 6.578 14.754 BLAminus -140.81, 169.83 55.63, 72.68 -84.48, 27.67 300.0, 1.18 -58.86, -37.01 in-out in 8.233 Saltbr-out 4.248 HRD-in -77.94, -57.51 70.73, 8.99 out-in-in SNCoii in-in ActLoopNT-in 3.013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.98, 89.93 APE9-dihe-na -179.85, 149.23 APE8-dihe-in -56.28, 134.25 APE8-rot-in 299.51 APE67-dihe-in -61.78, -21.13 -52.49, -48.37 APE12-dist-in 13.006 APE11-dist-in 10.709 APE10-dist-in 6.616 APE9-dist-in 3.694 None TPO160 TPO160 XRAY 3.08 0.248 0.289 A 303 296 0 0 0 0 [[4, 286]] 1.0 7mkx CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QTWA 1 298 298.0 X3A:451 Type1 Inactive DFGin 7.73 15.217 BLAminus -131.36, 171.83 40.9, 66.71 -61.52, 26.46 278.45, 73.23 55.91, 3.95 out-out out 15.732 Saltbr-out 13.313 HRD-in -80.23, -54.25 80.72, -17.72 out-out-out SNCooo out-out ActLoopNT-out 8.125 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -93.97, 97.99 APE9-dihe-na -56.3, 134.54 APE8-dihe-in -84.65, 125.77 APE8-rot-in 290.71 APE67-dihe-in -53.75, -28.5 -99.0, -5.65 APE12-dist-out 20.622 APE11-dist-out 16.387 APE10-dist-out 19.661 APE9-dist-out 11.03 None None None XRAY 1.85 0.214 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qtw CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QU0A 1 298 298.0 X40:454 Type1 Inactive DFGin 8.208 15.216 BLAminus -137.77, 171.11 51.19, 48.86 -48.06, 22.21 276.83, 64.07 70.99, -93.38 out-out out 15.404 Saltbr-out 13.133 HRD-in -77.95, -57.59 82.19, -12.98 out-out-out SNCooo out-out ActLoopNT-out 6.995 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -80.6, 105.78 APE9-dihe-na -55.28, 133.76 APE8-dihe-in -87.35, 122.14 APE8-rot-in 286.9 APE67-dihe-in -53.38, -29.6 -99.0, -5.34 APE12-dist-out 20.003 APE11-dist-out 16.977 APE10-dist-out 19.489 APE9-dist-out 11.05 None None None XRAY 1.95 0.2 0.251 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qu0 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R9DA 1 298 298.0 X6B:590 Type1 Inactive DFGin 8.079 15.003 BLAminus -121.15, 171.34 50.75, 77.19 -81.47, 59.23 282.0, 70.7 42.22, -95.41 out-out out 14.344 Saltbr-out 13.877 HRD-in -79.82, -53.09 77.88, -18.23 out-out-out SNCooo out-out ActLoopNT-out 8.068 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -62.43, 100.13 APE9-dihe-na -65.78, 136.3 APE8-dihe-in -79.92, 127.08 APE8-rot-in 316.73 APE67-dihe-in -56.64, -26.83 -105.63, 0.44 APE12-dist-out 20.579 APE11-dist-out 17.238 APE10-dist-out 19.702 APE9-dist-out 11.175 None None None XRAY 1.95 0.208 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r9d CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R9OA 1 298 298.0 Z71:401 Type1 Inactive DFGin 7.709 14.949 BLAminus -124.92, 169.14 49.25, 74.17 -72.51, 33.52 279.64, 74.41 59.11, -27.51 out-out out 14.984 Saltbr-out 12.552 HRD-in -81.51, -55.77 82.39, -19.38 out-out-out SNCooo out-out ActLoopNT-out 7.653 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 146.46 APE9-dihe-na -63.83, 134.08 APE8-dihe-in -88.2, 125.53 APE8-rot-in 303.25 APE67-dihe-in -55.2, -29.65 -103.97, 0.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.638 APE9-dist-out 11.19 None None None XRAY 1.9 0.209 0.246 A 306 282 16 0 0 8 [[4, 286]] 1.0 3r9o CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RZBA 1 298 298.0 02Z:458 Type1 Inactive DFGin 7.849 15.011 BLAminus -134.02, 177.25 47.06, 50.38 -50.09, -22.29 279.93, 72.46 71.6, 17.08 out-out out 14.525 Saltbr-out 10.733 HRD-in -86.05, -51.61 79.43, -21.53 out-out-out SNCooo out-out ActLoopNT-out 7.992 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 174.25 APE9-dihe-na -55.19, 127.5 APE8-dihe-in -87.87, 126.45 APE8-rot-in 311.53 APE67-dihe-in -53.26, -30.3 -104.83, -2.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.58 APE9-dist-out 11.151 None None None XRAY 1.9 0.205 0.245 A 306 282 16 0 0 8 [[4, 286]] 1.0 3rzb CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1VYWA 1 298 298.0 292:62300 Type1 Inactive DFGin 6.31 15.448 BLAminus -142.09, -179.46 62.07, 68.01 -93.04, 26.77 283.3, 67.04 -60.71, -37.42 in-in in 8.774 Saltbr-in 2.688 HRD-in -75.98, -56.94 73.1, 1.68 in-in-out SNCiio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -141.65, 150.84 APE9-dihe-na -49.59, 152.46 APE8-dihe-in -61.68, 143.78 APE8-rot-out 189.06 APE67-dihe-in -52.32, -27.96 -37.01, -54.78 APE12-dist-in 10.865 APE11-dist-out 6.148 APE10-dist-out 9.397 APE9-dist-in 3.864 None None None XRAY 2.3 0.229 0.258 A 309 298 0 0 0 0 [[4, 286]] 1.0 1vyw CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2BPMA 1 298 298.0 529:61299 Type1 Inactive DFGin 6.239 15.11 BLAminus -142.26, 176.11 58.91, 81.01 -97.86, 30.66 284.19, 66.4 -66.03, -17.23 in-in in 8.702 Saltbr-in 3.207 HRD-in -74.89, -55.37 69.86, 9.24 in-in-out SNCiio in-out ActLoopNT-in 2.876 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -145.78, 149.41 APE9-dihe-na -60.82, 153.33 APE8-dihe-in -56.05, 145.85 APE8-rot-out 190.64 APE67-dihe-in -49.62, -26.99 -36.83, -56.93 APE12-dist-in 10.954 APE11-dist-out 6.128 APE10-dist-out 9.188 APE9-dist-in 3.97 None None None XRAY 2.4 0.229 0.271 A 309 298 0 0 0 0 [[4, 286]] 1.0 2bpm CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C4GA 1 297 298.0 514:60306 Type1 Inactive DFGin 6.374 15.686 BLAminus -138.0, -179.21 56.78, 81.52 -100.19, 24.26 280.76, 69.34 -56.0, -30.57 in-in in 9.074 Saltbr-in 3.53 HRD-in -75.28, -49.4 66.04, 8.2 in-in-out SNCiio in-out ActLoopNT-in 2.765 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -135.18, 160.53 APE9-dihe-na -59.36, 149.34 APE8-dihe-in -58.64, 140.5 APE8-rot-out 179.78 APE67-dihe-in -54.42, -23.62 -30.84, -55.83 APE12-dist-in 10.723 APE11-dist-out 5.978 APE10-dist-out 9.285 APE9-dist-in 3.726 None None None XRAY 2.7 0.233 0.25 A 309 297 0 0 0 0 [[4, 286]] 1.0 2c4g CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WIHA 1 298 298.0 P48:61299 Type1 Inactive DFGin 6.323 15.153 BLAminus -141.48, 174.43 62.06, 78.82 -96.32, 29.99 282.61, 69.45 -63.78, -17.45 in-in in 8.899 Saltbr-in 2.735 HRD-in -77.3, -59.72 79.63, -0.51 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -126.75, 155.26 APE9-dihe-na -53.97, 153.09 APE8-dihe-in -55.51, 151.53 APE8-rot-out 190.5 APE67-dihe-in -57.21, -28.57 -52.08, -46.97 APE12-dist-in 10.856 APE11-dist-out 6.1 APE10-dist-out 9.308 APE9-dist-in 3.946 None None None XRAY 2.5 0.215 0.25 A 309 298 0 0 0 0 [[4, 286]] 1.0 2wih CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WIPA 1 298 298.0 P49:61299 Type1 Inactive DFGin 6.213 14.953 BLAminus -142.46, 178.98 56.18, 81.9 -99.03, 23.63 283.85, 66.21 -56.05, -33.18 in-in in 8.634 Saltbr-in 2.853 HRD-in -72.23, -57.81 81.71, -8.44 in-in-out SNCiio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -130.17, 149.32 APE9-dihe-na -61.56, 147.19 APE8-dihe-in -53.43, 148.35 APE8-rot-out 180.82 APE67-dihe-in -63.04, -20.64 -55.16, -41.78 APE12-dist-in 10.952 APE11-dist-out 6.172 APE10-dist-out 9.445 APE9-dist-in 3.754 None None None XRAY 2.8 0.221 0.258 A 309 293 5 0 0 0 [[4, 286]] 1.0 2wip CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WIPC 1 296 298.0 P49:61297 Type1 Inactive DFGin 6.239 14.98 BLAminus -141.29, -179.48 53.82, 83.38 -100.32, 23.88 283.87, 67.06 -55.38, -33.16 in-in in 8.625 Saltbr-in 2.839 HRD-in -72.71, -56.85 82.33, -8.67 in-in-out SNCiio in-out ActLoopNT-in 2.807 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.79, -53.2 APE9-dihe-na -69.06, 145.9 APE8-dihe-in -52.62, 147.98 APE8-rot-out 180.17 APE67-dihe-in -61.14, -22.34 -56.62, -40.71 APE12-dist-in 13.16 APE11-dist-in 12.121 APE10-dist-in 6.699 APE9-dist-in 3.739 None None None XRAY 2.8 0.221 0.258 C 309 291 5 0 0 0 [[4, 286]] 1.0 2wip CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WPAA 1 298 298.0 889:61301 Type1 Inactive DFGin 6.403 15.335 BLAminus -135.21, 176.53 58.02, 88.7 -107.68, 28.03 282.69, 64.08 -64.19, -28.37 in-in in 8.816 Saltbr-in 3.082 HRD-in -79.47, -55.07 78.51, -3.12 in-in-out SNCiio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -130.67, 154.23 APE9-dihe-na -48.84, 141.61 APE8-dihe-in -52.21, 154.2 APE8-rot-out 181.43 APE67-dihe-in -63.89, -20.76 -52.89, -45.76 APE12-dist-in 10.982 APE11-dist-out 6.302 APE10-dist-out 9.354 APE9-dist-in 3.669 None None None XRAY 2.51 0.223 0.261 A 309 298 0 0 0 0 [[4, 286]] 1.0 2wpa CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WXVA 1 298 298.0 WXV:61299 Type1 Inactive DFGin 6.349 15.217 BLAminus -142.15, 179.34 61.25, 75.54 -95.71, 30.2 288.43, 61.13 -64.45, -20.88 in-in in 9.154 Saltbr-in 2.788 HRD-in -80.45, -59.16 79.81, 3.89 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -129.11, 152.72 APE9-dihe-na -47.52, 148.72 APE8-dihe-in -58.45, 150.0 APE8-rot-out 188.9 APE67-dihe-in -58.49, -20.25 -50.64, -47.18 APE12-dist-in 11.14 APE11-dist-out 6.199 APE10-dist-out 9.4 APE9-dist-in 3.978 None None None XRAY 2.6 0.211 0.243 A 309 298 0 0 0 0 [[4, 286]] 1.0 2wxv CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2WXVC 1 298 298.0 WXV:61299 Type1 Inactive DFGin 6.436 15.754 BLAminus -137.28, 178.13 57.28, 77.18 -93.24, 25.48 280.18, 69.88 -57.67, -33.57 in-in in 9.05 Saltbr-in 2.751 HRD-in -85.48, -52.71 75.37, -2.61 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, -70.34 APE9-dihe-na -55.13, 128.55 APE8-dihe-in -50.61, 142.19 APE8-rot-out 174.77 APE67-dihe-in -59.06, -25.31 -62.32, -39.8 APE12-dist-in 13.841 APE11-dist-in 12.241 APE10-dist-in 7.071 APE9-dist-in 3.703 None None None XRAY 2.6 0.211 0.243 C 309 298 0 0 0 0 [[4, 286]] 1.0 2wxv CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOKA 1 297 298.0 4SP:60301 Type1 Inactive DFGin 6.758 14.917 BLAminus -134.3, -179.84 46.41, 76.35 -85.3, 26.99 282.69, 74.66 -63.13, -40.98 in-in in 8.405 Saltbr-in 2.751 HRD-in -74.27, -58.79 75.22, 5.66 in-in-out SNCiio in-out ActLoopNT-in 3.154 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -48.8, 159.15 APE9-dihe-na 69.58, 123.71 APE8-dihe-in -65.07, 144.66 APE8-rot-out 74.13 APE67-dihe-in -57.65, -17.47 -43.62, -55.86 APE12-dist-in 12.685 APE11-dist-in 9.044 APE10-dist-in 6.584 APE9-dist-in 3.22 H84S,Q85M,K89D TPO160 TPO160 XRAY 2.57 0.225 0.259 A 300 293 4 0 0 0 [[4, 286]] 1.0 4eok CMGC_CDK2_HUMAN CMGC 2.1e-89 306.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOKC 1 297 298.0 4SP:60301 Type1 Inactive DFGin 6.679 14.976 BLAminus -133.72, 176.62 49.75, 77.33 -90.85, 27.24 282.19, 75.0 -59.18, -42.5 in-in in 8.555 Saltbr-in 2.678 HRD-in -87.05, -50.89 65.34, 17.25 in-in-out SNCiio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.36, 150.06 APE9-dihe-na 67.77, 135.16 APE8-dihe-in -66.26, 146.78 APE8-rot-out 54.84 APE67-dihe-in -67.63, -15.19 -39.34, -49.74 APE12-dist-in 12.965 APE11-dist-in 10.176 APE10-dist-in 7.022 APE9-dist-in 3.364 H84S,Q85M,K89D TPO160 TPO160 XRAY 2.57 0.225 0.259 C 300 297 0 0 0 0 [[4, 286]] 1.0 4eok CMGC_CDK2_HUMAN CMGC 2.1e-89 306.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOLA 1 297 298.0 1RO:60301 Type1 Inactive DFGin 6.607 15.129 BLAminus -135.34, 178.76 52.69, 78.64 -93.77, 24.68 279.7, 73.17 -67.66, -22.78 in-in in 8.475 Saltbr-in 2.603 HRD-in -77.83, -51.08 67.91, 10.46 in-in-out SNCiio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -47.84, 152.66 APE9-dihe-na 70.88, 128.41 APE8-dihe-in -63.25, 140.1 APE8-rot-out 109.89 APE67-dihe-in -57.3, -27.39 -42.52, -53.62 APE12-dist-in 12.934 APE11-dist-in 9.113 APE10-dist-in 7.001 APE9-dist-in 3.265 H84S,Q85M,K89D TPO160 TPO160 XRAY 2.4 0.22 0.246 A 300 294 3 0 0 0 [[4, 286]] 1.0 4eol CMGC_CDK2_HUMAN CMGC 2.1e-89 306.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EOLC 1 297 298.0 1RO:60301 Type1 Inactive DFGin 6.451 14.894 BLAminus -145.3, 177.27 50.92, 76.98 -90.22, 25.77 287.42, 70.08 -65.23, -28.63 in-in in 8.481 Saltbr-in 2.726 HRD-in -76.44, -57.62 72.84, 10.6 in-in-out SNCiio in-out ActLoopNT-in 3.053 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.35, 153.03 APE9-dihe-na 66.62, 132.64 APE8-dihe-in -69.73, 142.81 APE8-rot-out 77.64 APE67-dihe-in -60.23, -13.71 -39.45, -54.36 APE12-dist-in 12.793 APE11-dist-in 10.134 APE10-dist-in 6.914 APE9-dist-in 3.157 H84S,Q85M,K89D TPO160 TPO160 XRAY 2.4 0.22 0.246 C 300 297 0 0 0 0 [[4, 286]] 1.0 4eol CMGC_CDK2_HUMAN CMGC 2.1e-89 306.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3F5XA 1 298 298.0 EZV:300 Type1.5_Back Inactive DFGin 6.264 15.144 BLAminus -134.58, -179.48 51.7, 79.18 -97.87, 23.07 283.96, 70.29 -60.84, -38.34 in-in in 8.688 Saltbr-in 2.691 HRD-in -75.24, -51.59 71.39, 2.05 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -175.83, 160.35 APE9-dihe-na 3.68, 102.57 APE8-dihe-in -38.96, 146.61 APE8-rot-out 193.19 APE67-dihe-in -61.73, -24.77 -51.83, -42.77 APE12-dist-in 11.503 APE11-dist-in 8.374 APE10-dist-out 8.433 APE9-dist-in 4.006 None None None XRAY 2.4 0.266 0.283 A 298 297 1 0 0 0 [[4, 286]] 1.0 3f5x CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3F5XC 1 298 298.0 EZV:300 Type1.5_Back Inactive DFGin 6.407 15.46 BLAminus -135.18, 179.33 51.86, 80.85 -99.79, 26.02 279.88, 72.23 -63.21, -36.5 in-in in 8.807 Saltbr-in 3.066 HRD-in -71.85, -53.32 74.6, -0.68 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 133.52, -152.44 APE9-dihe-na 7.07, 96.3 APE8-dihe-in -36.48, 145.34 APE8-rot-out 171.35 APE67-dihe-in -62.68, -23.78 -54.39, -38.57 APE12-dist-in 11.492 APE11-dist-in 8.799 APE10-dist-in 6.679 APE9-dist-in 3.934 None None None XRAY 2.4 0.266 0.283 C 298 298 0 0 0 0 [[4, 286]] 1.0 3f5x CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3PXFA 1 298 298.0 2AN:60304,2AN:60305 Allosteric,Type3 Inactive DFGin 6.804 14.953 BLBminus -156.99, 169.67 57.7, 49.35 -58.76, 147.9 286.72, 73.73 -84.97, 33.17 out-out out 17.118 Saltbr-out 15.963 HRD-in -83.12, -53.61 79.99, -16.11 out-out-out SNCooo out-out ActLoopNT-out 10.28 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -144.89, 166.86 APE9-dihe-na -179.55, 11.71 APE8-dihe-out -60.35, -25.0 APE8-rot-in 308.45 APE67-dihe-in -57.16, -27.46 -60.95, -33.0 APE12-dist-out 17.995 APE11-dist-out 18.625 APE10-dist-out 15.567 APE9-dist-out 11.402 None None None XRAY 1.8 0.198 0.229 A 306 298 0 0 0 0 [[4, 286]] 1.0 3pxf CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3PXZA 1 298 298.0 2AN:60299,2AN:60300,JWS:60301 Allosteric,Type3,Type1 Inactive DFGin 6.837 15.033 BLBminus -155.67, 166.51 60.28, 50.57 -60.22, 145.8 284.9, 75.18 -84.49, 38.36 out-out out 17.125 Saltbr-out 15.789 HRD-in -85.51, -53.14 79.88, -15.95 out-out-out SNCooo out-out ActLoopNT-out 10.493 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -158.71, 154.36 APE9-dihe-na -170.99, 21.17 APE8-dihe-out -68.66, -23.41 APE8-rot-in 291.0 APE67-dihe-in -58.73, -27.74 -57.67, -32.22 APE12-dist-out 18.609 APE11-dist-out 18.664 APE10-dist-out 15.39 APE9-dist-out 11.201 None None None XRAY 1.7 0.214 0.256 A 306 298 0 0 0 0 [[4, 286]] 1.0 3pxz CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6YL6A 1 298 298.0 No_ligand No_ligand Inactive DFGin 10.863 18.115 BLBminus -103.63, 148.99 75.14, 24.25 -51.89, 141.19 255.4, 92.77 84.95, -19.74 out-out out 15.757 Saltbr-out 17.82 HRD-in -85.94, -59.1 81.31, -16.09 out-out-out SNCooo out-out ActLoopNT-out 5.714 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.56, 129.93 APE9-dihe-na -73.61, 128.6 APE8-dihe-in -68.6, 141.32 APE8-rot-out 185.54 APE67-dihe-in -63.71, -24.64 -98.13, -3.21 APE12-dist-out 19.604 APE11-dist-out 17.493 APE10-dist-out 18.694 APE9-dist-out 10.68 F80C,C177A None None XRAY 1.7 0.181 999.0 A 303 298 0 0 0 0 [[4, 286]] 1.0 6yl6 CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7UXIA 2 298 298.0 No_ligand No_ligand Inactive DFGin 7.325 16.323 BLBminus -139.56, 169.86 72.82, 31.27 -62.6, 132.48 291.85, 80.25 77.82, 0.77 out-out out 15.264 Saltbr-out 14.935 HRD-in -80.34, -52.7 82.21, -18.9 out-out-out SNCooo out-out ActLoopNT-out 10.275 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -66.01, -43.19 APE9-dihe-na -72.45, -32.29 APE8-dihe-out -82.35, -8.83 APE8-rot-in 318.55 APE67-dihe-in -63.65, -20.19 -64.17, -39.1 APE12-dist-none 999.0 APE11-dist-in 12.42 APE10-dist-out 15.427 APE9-dist-out 11.047 None None None XRAY 2.07 0.213 0.264 A 299 280 17 0 0 10 [[4, 286]] 1.0 7uxi CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5OO3A 2 294 298.0 9ZB:301 Type1 Inactive DFGin 10.277 17.84 BLBminus -105.88, 161.12 68.35, 21.75 -51.13, 140.89 255.15, 98.44 84.24, -24.81 out-out out 15.845 Saltbr-out 17.272 HRD-in -86.8, -57.25 80.19, -12.06 out-out-out SNCooo out-out ActLoopNT-out 6.034 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.26, 128.65 APE9-dihe-na -76.42, 126.3 APE8-dihe-in -64.14, 140.44 APE8-rot-out 189.48 APE67-dihe-in -65.38, -23.78 -96.62, -3.82 APE12-dist-out 18.961 APE11-dist-out 16.837 APE10-dist-out 18.193 APE9-dist-out 10.629 F80C,C177A None None XRAY 1.73 0.187 0.249 A 303 286 7 0 0 0 [[4, 286]] 1.0 5oo3 CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6YL1A 1 298 298.0 OWN:60301 Type1 Inactive DFGin 7.95 15.24 BLBminus -143.36, 162.7 66.75, 47.2 -58.43, 136.45 285.0, 64.94 -84.51, 131.85 out-out out 14.75 Saltbr-out 11.873 HRD-in -82.26, -54.45 85.26, -17.45 out-out-out SNCooo out-out ActLoopNT-out 9.23 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -124.6, 139.89 APE9-dihe-na -62.39, 127.0 APE8-dihe-in -79.51, 132.47 APE8-rot-in 318.07 APE67-dihe-in -63.6, -24.03 -104.61, -3.32 APE12-dist-none 999.0 APE11-dist-out 18.366 APE10-dist-out 19.344 APE9-dist-out 10.63 F80C,C177A None None XRAY 1.66 0.221 0.269 A 303 282 16 0 0 8 [[4, 286]] 1.0 6yl1 CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6YLKA 1 298 298.0 OY2:60301 Type1 Inactive DFGin 7.952 15.498 BLBminus -142.19, 161.67 68.26, 47.12 -55.19, 133.15 279.48, 76.41 -85.9, 135.49 out-out out 14.633 Saltbr-out 12.008 HRD-in -80.3, -49.52 80.8, -21.78 out-out-out SNCooo out-out ActLoopNT-out 9.917 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -64.14, -26.57 APE9-dihe-na -84.23, 3.13 APE8-dihe-out -54.63, -49.39 APE8-rot-in 298.42 APE67-dihe-in -64.89, -21.17 -94.45, -4.99 APE12-dist-out 19.148 APE11-dist-out 18.717 APE10-dist-out 22.913 APE9-dist-out 12.38 F80C,C177A None None XRAY 1.65 0.218 0.265 A 303 290 8 0 0 0 [[4, 286]] 1.0 6ylk CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1DM2A 1 298 298.0 HMD:400 Type1 Inactive DFGin 8.083 15.174 BLBminus -135.33, 165.14 60.62, 59.67 -72.31, 120.69 284.69, 66.98 -63.1, 154.86 out-out out 14.661 Saltbr-out 13.059 HRD-in -85.27, -51.86 82.75, -26.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.99 APE8-dihe-in -79.63, 132.91 APE8-rot-in 302.05 APE67-dihe-in -50.64, -29.01 -107.85, 0.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.85 None None None XRAY 2.1 0.228 0.267 A 298 274 24 0 0 15 [[4, 286]] 1.0 1dm2 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1G5SA 1 298 298.0 I17:400 Type1 Inactive DFGin 8.115 15.085 BLBminus -133.53, 166.37 48.49, 70.76 -65.03, -169.31 288.65, 66.47 -113.64, -144.89 out-out out 14.437 Saltbr-out 15.731 HRD-in -81.81, -51.14 79.05, -24.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 69.48 APE9-dihe-na -71.54, 141.91 APE8-dihe-in -80.46, 140.28 APE8-rot-in 302.83 APE67-dihe-in -56.57, -23.66 -123.68, -3.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.631 APE9-dist-out 11.556 None None None XRAY 2.61 0.201 0.242 A 298 275 23 0 0 14 [[4, 286]] 1.0 1g5s CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1P2AA 1 298 298.0 5BN:301 Type1 Inactive DFGin 8.291 15.384 BLBminus -135.83, 154.98 66.07, 45.16 -52.68, 139.63 284.12, 63.94 -91.55, 168.0 out-out out 14.635 Saltbr-out 13.838 HRD-in -81.24, -45.32 77.95, -29.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -17.11 APE8-dihe-in -87.95, 131.35 APE8-rot-in 296.72 APE67-dihe-in -44.63, -35.11 -105.7, -4.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.348 None None None XRAY 2.5 0.206 0.28 A 298 271 27 0 0 14 [[4, 286]] 1.0 1p2a CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PF8A 1 298 298.0 SU9:500 Type1 Inactive DFGin 8.475 15.741 BLBminus -129.7, 146.62 62.68, 69.99 -68.65, 116.11 284.82, 69.79 -69.63, 152.74 out-out out 14.943 Saltbr-out 11.878 HRD-in -101.08, -46.86 78.76, -29.91 out-out-out SNCooo out-out ActLoopNT-out 9.501 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -74.3, 116.67 APE9-dihe-na -125.72, -92.3 APE8-dihe-in -84.61, 116.88 APE8-rot-out 174.62 APE67-dihe-in -66.44, -33.29 -122.64, 33.07 APE12-dist-out 18.72 APE11-dist-in 13.677 APE10-dist-out 15.284 APE9-dist-out 12.387 None None None XRAY 2.51 0.208 0.306 A 298 298 0 0 0 0 [[4, 286]] 1.0 1pf8 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2B52A 1 298 298.0 D42:299 Type1 Inactive DFGin 8.893 15.268 BLBminus -141.64, 169.72 53.46, 46.38 -53.81, 159.81 285.46, 64.51 -81.56, 93.65 out-out out 15.004 Saltbr-out 14.984 HRD-in -82.92, -50.4 80.09, -21.1 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -159.99, 74.27 APE9-dihe-na -52.16, 130.95 APE8-dihe-in -78.6, 151.41 APE8-rot-out 59.38 APE67-dihe-in -45.68, -32.57 -107.57, -0.59 APE12-dist-out 19.475 APE11-dist-out 18.176 APE10-dist-out 20.224 APE9-dist-out 10.755 None None None XRAY 1.88 0.219 0.275 A 298 283 15 0 0 11 [[4, 286]] 1.0 2b52 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2B55A 1 298 298.0 D31:299 Type1 Inactive DFGin 8.587 15.146 BLBminus -143.99, 166.23 55.34, 53.27 -57.84, 157.15 282.56, 63.76 -67.56, 999.0 out-out out 14.909 Saltbr-out 15.496 HRD-in -82.43, -49.58 79.3, -23.81 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 107.35 APE9-dihe-na -74.82, 135.43 APE8-dihe-in -72.48, 144.46 APE8-rot-out 176.71 APE67-dihe-in -48.29, -30.13 -111.52, -5.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.846 None None None XRAY 1.85 0.213 0.256 A 298 276 22 0 0 15 [[4, 286]] 1.0 2b55 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2BHEA 1 298 298.0 BRY:1299 Type1 Inactive DFGin 8.566 15.479 BLBminus -119.95, 159.77 54.95, 56.83 -56.89, 138.54 291.8, 58.17 -95.42, 153.43 out-out out 15.015 Saltbr-out 11.977 HRD-in -80.13, -51.98 82.04, -20.94 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -24.27 APE8-dihe-in -71.12, 121.18 APE8-rot-in 287.89 APE67-dihe-in -66.24, -23.49 -99.49, 11.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.13 None None None XRAY 1.9 0.246 0.322 A 298 274 24 0 0 15 [[4, 286]] 1.0 2bhe CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2BHHA 1 298 298.0 RYU:1299 Type1 Inactive DFGin 8.374 16.731 BLBminus -90.01, 171.16 32.35, 80.04 -64.56, 114.63 263.52, 80.58 -60.68, 123.83 out-out out 15.485 Saltbr-out 15.878 HRD-in -83.09, -51.19 79.21, -29.81 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -3.46 APE8-dihe-in -109.93, 126.87 APE8-rot-in 293.41 APE67-dihe-in -44.53, -42.0 -104.51, -7.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.984 None None None XRAY 2.6 0.244 0.325 A 298 274 24 0 0 15 [[4, 286]] 1.0 2bhh CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2BTSA 1 298 298.0 U32:1299 Type1 Inactive DFGin 8.571 15.954 BLBminus -131.25, 144.03 57.41, 68.71 -62.53, 135.6 279.58, 62.82 -80.98, 150.36 out-out out 15.624 Saltbr-out 14.997 HRD-in -78.23, -53.97 79.57, -25.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 156.64 APE8-dihe-in -86.98, 135.56 APE8-rot-in 291.23 APE67-dihe-in -60.1, -28.56 -107.23, -11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.197 None None None XRAY 1.99 0.216 0.261 A 298 274 24 0 0 15 [[4, 286]] 1.0 2bts CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C5YA 1 297 298.0 MTW:1298 Type1 Inactive DFGin 9.4 16.657 BLBminus -119.33, 163.14 63.9, 25.09 -37.93, 176.97 281.77, 102.48 32.41, -5.42 out-out out 15.829 Saltbr-out 18.808 HRD-in -83.1, -53.31 80.34, -18.94 out-out-out SNCooo out-out ActLoopNT-out 5.984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.09, 126.86 APE9-dihe-na -82.0, 122.2 APE8-dihe-in -67.98, 138.89 APE8-rot-out 178.11 APE67-dihe-in -60.87, -23.53 -96.51, 2.32 APE12-dist-out 19.365 APE11-dist-out 17.172 APE10-dist-out 18.356 APE9-dist-out 10.546 None None None XRAY 2.25 0.172 0.295 A 298 290 7 0 0 0 [[4, 286]] 1.0 2c5y CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2FVDA 1 298 298.0 LIA:299 Type1 Inactive DFGin 8.27 15.847 BLBminus -129.08, 161.73 54.66, 55.26 -58.18, 137.13 271.85, 72.54 -100.76, 151.69 out-out out 14.71 Saltbr-out 11.728 HRD-in -85.22, -52.32 84.78, -19.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.5, -29.7 APE9-dihe-na -80.34, -3.97 APE8-dihe-out -41.1, -43.49 APE8-rot-in 299.83 APE67-dihe-in -55.14, -24.36 -106.63, -5.17 APE12-dist-out 21.16 APE11-dist-out 18.528 APE10-dist-out 23.032 APE9-dist-out 12.501 None None None XRAY 1.85 0.207 0.235 A 298 284 14 0 0 2 [[4, 286]] 1.0 2fvd CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2J9MA 1 298 298.0 PY8:299 Type1 Inactive DFGin 8.03 15.527 BLBminus -117.85, 155.78 63.5, 58.0 -58.66, 135.53 288.36, 61.8 -84.13, 156.08 out-out out 14.938 Saltbr-out 13.62 HRD-in -68.66, -54.24 85.35, -33.48 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 25.87 APE8-dihe-in -127.82, 119.52 APE8-rot-in 290.66 APE67-dihe-in -54.74, -26.86 -98.36, 2.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.774 None None None XRAY 2.5 0.219 0.294 A 298 275 23 0 0 15 [[4, 286]] 1.0 2j9m CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTNA 1 298 298.0 LZ7:1299 Type1 Inactive DFGin 8.225 15.48 BLBminus -130.59, 169.64 59.02, 44.37 -44.98, 149.46 274.53, 71.88 -46.74, 999.0 out-out out 15.013 Saltbr-out 10.346 HRD-in -71.77, -52.62 82.25, -20.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 15.58 APE8-dihe-in -73.85, 143.51 APE8-rot-in 326.04 APE67-dihe-in -55.91, -32.82 -112.63, -13.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.04 None None None XRAY 2.2 0.207 0.251 A 298 274 24 0 0 16 [[4, 286]] 1.0 2vtn CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTQA 1 298 298.0 LZA:1299 Type1 Inactive DFGin 8.044 14.046 BLBminus -129.75, 168.07 58.97, 49.95 -59.94, 124.1 301.31, 117.69 -69.88, 999.0 out-out out 15.12 Saltbr-out 15.345 HRD-in -77.76, -54.42 82.1, -19.72 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 147.28 APE9-dihe-na -86.24, 119.48 APE8-dihe-in -63.08, 130.94 APE8-rot-in 312.05 APE67-dihe-in -59.55, -25.84 -105.72, -2.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.668 None None None XRAY 1.9 0.202 0.244 A 298 274 24 0 0 15 [[4, 286]] 1.0 2vtq CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTTA 1 298 298.0 LZD:1299 Type1 Inactive DFGin 8.256 15.788 BLBminus -133.83, 163.13 58.79, 49.54 -50.81, 118.96 266.7, 80.52 -61.31, 131.96 out-out out 14.895 Saltbr-out 15.463 HRD-in -78.88, -51.32 81.52, -27.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 23.3 APE8-dihe-out -41.16, -42.29 APE8-rot-in 294.63 APE67-dihe-in -54.78, -27.63 -116.87, -16.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.407 None None None XRAY 1.68 0.201 0.227 A 298 272 26 0 0 15 [[4, 286]] 1.0 2vtt CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VU3A 1 298 298.0 LZE:1299 Type1 Inactive DFGin 8.322 15.708 BLBminus -139.52, 167.07 59.03, 42.09 -48.49, 136.01 273.65, 80.97 -89.56, 999.0 out-out out 14.825 Saltbr-out 14.507 HRD-in -75.5, -58.82 93.01, -22.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -57.28, -32.4 APE9-dihe-na -76.07, 0.26 APE8-dihe-out -51.02, -50.13 APE8-rot-in 294.74 APE67-dihe-in -56.87, -26.43 -97.91, -6.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.782 None None None XRAY 1.85 0.205 0.246 A 298 285 13 0 0 4 [[4, 286]] 1.0 2vu3 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3TI1A 1 298 298.0 B49:299 Type1 Inactive DFGin 7.489 14.948 BLBminus -138.54, 165.85 55.25, 50.84 -54.7, 138.08 282.79, 63.1 -95.42, 15.79 out-out out 16.039 Saltbr-out 14.61 HRD-in -73.91, -54.49 74.09, -22.19 out-out-out SNCooo out-out ActLoopNT-out 7.753 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -103.63, 110.78 APE9-dihe-na -67.36, 128.32 APE8-dihe-in -75.16, 126.28 APE8-rot-in 271.07 APE67-dihe-in -58.11, -32.93 -95.87, -2.85 APE12-dist-out 22.302 APE11-dist-out 17.662 APE10-dist-out 19.612 APE9-dist-out 10.928 None None None XRAY 1.99 0.205 0.262 A 298 294 4 0 0 0 [[4, 286]] 1.0 3ti1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3TIZA 2 298 298.0 3TI:299 Type1 Inactive DFGin 10.973 17.532 BLBminus -121.88, 153.78 71.63, 29.3 -62.4, 138.79 252.83, 105.63 73.11, -2.13 out-out out 15.481 Saltbr-out 14.687 HRD-in -81.14, -61.85 79.6, -22.98 out-out-out SNCooo out-out ActLoopNT-out 5.806 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.61, 119.72 APE9-dihe-na -69.51, 139.31 APE8-dihe-in -83.35, 120.56 APE8-rot-in 316.47 APE67-dihe-in -57.22, -29.02 -92.83, -8.7 APE12-dist-out 21.169 APE11-dist-out 17.662 APE10-dist-out 19.63 APE9-dist-out 11.076 None None None XRAY 2.02 0.193 0.243 A 298 293 4 0 0 0 [[4, 286]] 1.0 3tiz CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3UNJA 1 298 298.0 0BX:299 Type1 Inactive DFGin 9.438 16.055 BLBminus -126.16, 158.39 62.91, 62.36 -77.38, -172.61 283.66, 79.73 54.11, -145.34 out-out out 16.135 Saltbr-out 15.089 HRD-in -80.95, -60.65 73.54, -8.03 out-out-out SNCooo out-out ActLoopNT-out 6.541 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.71, 161.6 APE9-dihe-na -82.53, 132.15 APE8-dihe-in -80.46, 120.61 APE8-rot-in 287.27 APE67-dihe-in -57.53, -30.48 -95.93, -10.88 APE12-dist-out 19.108 APE11-dist-out 15.322 APE10-dist-out 17.398 APE9-dist-out 10.259 None None None XRAY 1.9 0.199 0.261 A 298 294 4 0 0 0 [[4, 286]] 1.0 3unj CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3UNKA 1 298 298.0 0BY:299 Type1 Inactive DFGin 10.533 16.223 BLBminus -114.51, 154.53 72.02, 37.13 -66.62, 159.38 284.73, 91.48 68.14, 3.66 out-out out 15.727 Saltbr-out 15.237 HRD-in -82.35, -66.03 72.22, -7.05 out-out-out SNCooo out-out ActLoopNT-out 6.064 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -93.01, 107.46 APE9-dihe-na -73.24, 145.2 APE8-dihe-in -85.61, 121.8 APE8-rot-in 315.14 APE67-dihe-in -60.87, -28.03 -91.32, -9.56 APE12-dist-out 20.477 APE11-dist-out 15.907 APE10-dist-out 19.29 APE9-dist-out 10.867 None None None XRAY 2.1 0.18 0.234 A 298 295 3 0 0 0 [[4, 286]] 1.0 3unk CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5ANGA 2 298 298.0 WY3:1299 Type1 Inactive DFGin 8.868 15.157 BLBminus -130.67, 171.05 57.07, 51.35 -60.9, 146.23 281.41, 63.94 -94.86, 128.98 out-out out 15.002 Saltbr-out 16.558 HRD-in -78.59, -53.71 84.86, -19.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 134.85 APE9-dihe-na -71.3, 134.15 APE8-dihe-in -89.85, 123.32 APE8-rot-out 177.6 APE67-dihe-in -58.83, -24.55 -100.56, -2.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.521 APE9-dist-out 11.042 None None None XRAY 1.9 0.199 0.236 A 298 268 29 0 0 14 [[4, 286]] 1.0 5ang CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7M2FA 1 298 298.0 YOS:901 Type1 Inactive DFGin 8.238 15.928 BLBminus -124.95, 157.78 58.01, 58.37 -57.83, 131.16 273.81, 74.67 -79.75, 999.0 out-out out 14.915 Saltbr-out 14.506 HRD-in -84.12, -50.42 80.86, -23.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -59.96, -32.85 APE9-dihe-na -80.07, -7.31 APE8-dihe-out -42.65, -49.66 APE8-rot-in 298.23 APE67-dihe-in -56.75, -24.69 -99.35, -4.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.45 None None None XRAY 1.632 0.213 0.258 A 298 281 17 0 0 7 [[4, 286]] 1.0 7m2f CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9D0UA 1 298 298.0 A1A1H:301 Type1 Inactive DFGin 8.525 15.649 BLBminus -132.55, 155.33 56.61, 71.46 -74.59, 136.49 281.17, 65.2 -85.62, 123.9 out-out out 15.265 Saltbr-out 16.659 HRD-in -93.27, -34.94 68.53, -43.24 out-out-out SNCooo out-out ActLoopNT-out 9.727 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -37.05 APE9-dihe-na -84.27, -7.27 APE8-dihe-out -69.63, -34.14 APE8-rot-in 261.42 APE67-dihe-in -61.77, -19.59 -63.83, -33.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.764 APE9-dist-out 11.069 None None None XRAY 2.6 0.212 0.26 A 298 289 9 0 0 4 [[4, 286]] 1.0 9d0u CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8ERDA 1 298 298.0 WQ6:60301 Type1 Inactive DFGin 8.582 16.25 BLBminus -121.63, 153.55 64.02, 56.7 -53.48, 130.5 279.82, 76.74 -85.1, 132.91 out-out out 15.219 Saltbr-out 12.847 HRD-in -82.72, -53.82 84.17, -16.58 out-out-out SNCooo out-out ActLoopNT-out 8.31 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.0, 121.72 APE9-dihe-na -70.09, 126.97 APE8-dihe-in -72.45, 132.03 APE8-rot-in 300.88 APE67-dihe-in -65.57, -22.99 -101.28, -0.94 APE12-dist-out 22.29 APE11-dist-out 17.27 APE10-dist-out 19.93 APE9-dist-out 10.69 None None None XRAY 1.33 0.2 0.23 A 299 289 9 0 0 0 [[4, 286]] 1.0 8erd CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6INLA 1 298 298.0 AJR:900 Type1 Inactive DFGin 8.882 15.786 BLBminus -114.41, 156.22 62.32, 59.76 -55.94, 135.44 282.1, 69.83 -73.88, 999.0 out-out out 14.95 Saltbr-out 12.111 HRD-in -81.05, -54.19 74.12, -14.31 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 131.87 APE9-dihe-na -61.97, 121.14 APE8-dihe-in -76.94, 131.87 APE8-rot-in 298.25 APE67-dihe-in -66.19, -22.53 -100.18, -0.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.711 None None None XRAY 1.75 0.198 0.25 A 299 272 26 0 0 15 [[4, 286]] 1.0 6inl CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3NA 1 298 298.0 SCZ:60501 Type1 Inactive DFGin 8.416 15.479 BLBminus -121.51, 161.73 41.2, 69.04 -57.76, 139.27 285.76, 53.18 -53.0, -108.82 out-out out 14.723 Saltbr-out 13.652 HRD-in -85.77, -49.05 76.79, -22.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 999.0 APE9-dihe-na -82.82, 151.99 APE8-dihe-in -77.41, 140.97 APE8-rot-in 291.31 APE67-dihe-in -51.95, -31.61 -104.46, -5.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.536 APE9-dist-out 10.59 None None CSD177 XRAY 1.63 0.194 0.235 A 299 278 20 0 0 13 [[4, 286]] 1.0 2r3n CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VV9A 1 298 298.0 IM9:61300 Type1 Inactive DFGin 8.218 15.51 BLBminus -132.35, 168.28 58.62, 53.48 -56.5, 120.83 271.74, 69.98 -71.45, 67.58 out-out out 14.812 Saltbr-out 14.168 HRD-in -81.14, -53.22 85.21, -25.04 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 141.64 APE9-dihe-na -77.31, 132.24 APE8-dihe-in -82.9, 131.82 APE8-rot-in 288.88 APE67-dihe-in -62.1, -27.84 -105.84, -2.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.349 APE9-dist-out 10.742 None None None XRAY 1.9 0.191 0.228 A 299 279 19 0 0 13 [[4, 286]] 1.0 2vv9 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2W17A 1 298 298.0 I19:61300 Type1 Inactive DFGin 8.167 15.288 BLBminus -141.56, 164.03 56.33, 54.71 -56.05, 126.33 275.29, 58.06 -57.84, 112.26 out-out out 14.51 Saltbr-out 13.797 HRD-in -79.07, -54.07 82.47, -13.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 129.89 APE9-dihe-na -78.62, 144.12 APE8-dihe-in -83.44, 130.58 APE8-rot-in 331.95 APE67-dihe-in -64.21, -24.47 -97.58, -1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.515 APE9-dist-out 10.76 None None None XRAY 2.15 0.244 0.3 A 299 278 20 0 0 13 [[4, 286]] 1.0 2w17 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3SW7A 1 298 298.0 19K:60299 Type1 Inactive DFGin 8.833 15.538 BLBminus -125.05, 148.22 57.95, 72.53 -63.08, 133.83 291.84, 84.89 -87.94, 155.03 out-out out 15.136 Saltbr-out 12.624 HRD-in -82.34, -55.27 82.2, -11.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 127.1 APE9-dihe-na -65.13, 123.16 APE8-dihe-in -82.38, 129.61 APE8-rot-in 302.03 APE67-dihe-in -53.76, -28.96 -102.46, -4.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.76 APE9-dist-out 10.988 None None None XRAY 1.8 0.184 0.215 A 299 278 20 0 0 13 [[4, 286]] 1.0 3sw7 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BZDA 1 298 298.0 D6I:1300 Type1 Inactive DFGin 8.765 15.198 BLBminus -126.42, 161.93 70.87, 40.79 -59.87, 104.24 285.85, 66.11 -63.46, 149.33 out-none out 15.002 Saltbr-none 999.0 HRD-in -78.39, -56.59 87.31, -16.52 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 126.06 APE9-dihe-na -67.74, 131.97 APE8-dihe-in -81.87, 126.69 APE8-rot-in 299.36 APE67-dihe-in -62.2, -26.77 -100.75, -2.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.163 APE9-dist-out 11.001 None None None XRAY 1.83 0.175 0.204 A 299 277 21 0 0 14 [[4, 286]] 1.0 4bzd CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKOA 1 298 298.0 20K:60301 Type1 Inactive DFGin 8.666 15.426 BLBminus -125.43, 149.85 58.65, 75.86 -66.7, 135.67 292.47, 87.98 -92.67, 155.02 out-out out 15.142 Saltbr-out 13.061 HRD-in -80.88, -55.11 82.09, -14.53 out-out-out SNCooo out-out ActLoopNT-out 9.541 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -126.3, 148.91 APE9-dihe-na -72.88, 122.25 APE8-dihe-in -81.91, 129.97 APE8-rot-out 181.44 APE67-dihe-in -54.84, -27.69 -101.92, -3.56 APE12-dist-out 25.51 APE11-dist-out 19.876 APE10-dist-out 20.825 APE9-dist-out 11.033 None None None XRAY 1.55 0.177 0.199 A 299 291 7 0 0 0 [[4, 286]] 1.0 4fko CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3EZVA 1 298 298.0 EZV:300 Type1 Inactive DFGin 8.262 15.435 BLBminus -136.58, 166.86 64.1, 47.24 -55.25, 135.65 278.78, 70.77 -82.58, 149.84 out-out out 14.71 Saltbr-out 13.139 HRD-in -78.98, -52.27 84.47, -21.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 136.2 APE9-dihe-na -72.4, 130.59 APE8-dihe-in -82.3, 130.13 APE8-rot-out 173.31 APE67-dihe-in -55.91, -25.19 -101.39, -9.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.912 APE9-dist-out 10.695 None None None XRAY 1.99 0.228 0.244 A 300 277 21 0 0 14 [[4, 286]] 1.0 3ezv CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7RA5A 1 296 298.0 3I3:60301 Type1 Inactive DFGin 8.26 16.262 BLBminus -130.98, 161.74 65.66, 56.4 -59.51, 113.29 274.73, 77.08 -76.57, 141.92 out-out out 15.133 Saltbr-out 13.959 HRD-in -75.17, -54.32 86.45, -14.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 126.63 APE9-dihe-na -74.84, 124.49 APE8-dihe-in -68.75, 135.9 APE8-rot-out 188.92 APE67-dihe-in -62.25, -25.5 -106.26, -3.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.983 APE9-dist-out 10.556 None None None XRAY 1.67 0.23 0.274 A 300 276 20 0 0 13 [[4, 286]] 1.0 7ra5 CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8YNGA 1 298 298.0 A1D6S:60301 Type1 Inactive DFGin 7.83 15.57 BLBminus -126.5, 150.43 58.8, 62.69 -59.01, 143.24 282.79, 63.5 -92.6, 140.82 out-out out 14.465 Saltbr-out 11.549 HRD-in -77.58, -51.0 83.01, -21.74 out-out-out SNCooo out-out ActLoopNT-out 9.507 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -63.23, -29.54 APE9-dihe-na -79.02, 0.75 APE8-dihe-out -57.42, -40.04 APE8-rot-in 302.71 APE67-dihe-in -62.69, -22.41 -100.87, -8.87 APE12-dist-out 21.014 APE11-dist-out 18.439 APE10-dist-out 22.877 APE9-dist-out 12.131 None None None XRAY 1.82 0.194 0.235 A 301 292 6 0 0 0 [[4, 286]] 1.0 8yng CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8YPWA 1 298 298.0 A1D6Z:60301 Type1 Inactive DFGin 7.624 15.038 BLBminus -134.22, 155.58 54.17, 61.51 -58.95, 141.29 285.18, 62.75 -89.34, 141.87 out-out out 14.406 Saltbr-out 11.717 HRD-in -83.47, -48.65 82.57, -20.49 out-out-out SNCooo out-out ActLoopNT-out 9.753 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -58.36, -28.82 APE9-dihe-na -67.99, -23.82 APE8-dihe-out -66.86, -23.37 APE8-rot-out 61.9 APE67-dihe-in -61.36, -25.9 -59.94, -33.92 APE12-dist-out 19.254 APE11-dist-out 15.844 APE10-dist-out 20.371 APE9-dist-out 11.817 None None None XRAY 1.8 0.184 0.22 A 303 293 5 0 0 0 [[4, 286]] 1.0 8ypw CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8YQEA 1 298 298.0 A1D60:60301 Type1 Inactive DFGin 7.673 15.085 BLBminus -126.43, 154.87 50.87, 65.06 -60.99, 138.76 283.84, 66.6 -84.16, 138.89 out-out out 14.371 Saltbr-out 11.208 HRD-in -82.99, -45.76 76.34, -20.67 out-out-out SNCooo out-out ActLoopNT-out 9.386 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -5.99 APE9-dihe-na 38.28, 49.91 APE8-dihe-out -78.47, 41.42 APE8-rot-out 177.29 APE67-dihe-in -62.79, -26.98 -104.83, -22.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.817 APE9-dist-out 12.488 None None None XRAY 1.94 0.202 0.242 A 303 283 15 0 0 8 [[4, 286]] 1.0 8yqe CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9JJ5A 1 298 298.0 A1EB0:60301 Type1 Inactive DFGin 8.034 15.178 BLBminus -121.58, 162.45 51.13, 60.61 -56.94, 138.71 280.77, 73.38 -84.23, 142.47 out-out out 14.651 Saltbr-out 13.828 HRD-in -80.69, -53.91 85.81, -19.11 out-out-out SNCooo out-out ActLoopNT-out 9.677 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -104.38, 123.36 APE9-dihe-na -52.94, 132.38 APE8-dihe-in -83.2, 146.26 APE8-rot-out 72.21 APE67-dihe-in -60.72, -28.67 -101.72, 1.05 APE12-dist-none 999.0 APE11-dist-out 17.936 APE10-dist-out 19.197 APE9-dist-out 10.464 None None None XRAY 1.71 0.204 0.244 A 303 279 19 0 0 10 [[4, 286]] 1.0 9jj5 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3PXYA 1 298 298.0 JWS:299 Type1 Inactive DFGin 10.462 15.944 BLBminus -122.74, 154.77 71.04, 42.14 -72.87, 173.58 279.17, 102.98 35.69, 27.63 out-out out 15.43 Saltbr-out 16.322 HRD-in -89.87, -62.06 81.43, -12.05 out-out-out SNCooo out-out ActLoopNT-out 5.967 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -91.89, 94.51 APE9-dihe-na -54.64, 138.43 APE8-dihe-in -84.97, 123.48 APE8-rot-in 306.18 APE67-dihe-in -53.77, -24.31 -105.13, -10.69 APE12-dist-out 20.224 APE11-dist-out 16.509 APE10-dist-out 19.622 APE9-dist-out 11.08 None None None XRAY 1.8 0.211 0.242 A 306 294 4 0 0 0 [[4, 286]] 1.0 3pxy CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3PY0A 1 298 298.0 SU9:301 Type1 Inactive DFGin 9.476 16.027 BLBminus -126.7, 148.83 64.28, 62.26 -73.09, -162.69 281.47, 81.1 38.41, -126.13 out-out out 15.419 Saltbr-out 13.916 HRD-in -86.2, -57.87 84.15, -15.09 out-out-out SNCooo out-out ActLoopNT-out 6.493 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.56, 92.41 APE9-dihe-na -54.93, 126.96 APE8-dihe-in -79.79, 125.98 APE8-rot-in 309.86 APE67-dihe-in -53.56, -27.28 -105.18, -7.46 APE12-dist-out 19.559 APE11-dist-out 15.444 APE10-dist-out 19.22 APE9-dist-out 11.139 None None None XRAY 1.75 0.212 0.26 A 306 294 4 0 0 0 [[4, 286]] 1.0 3py0 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QQGA 1 298 298.0 X06:300 Type1 Inactive DFGin 10.744 16.408 BLBminus -121.57, 152.3 74.48, 40.06 -71.29, 157.64 270.44, 101.52 47.86, 32.19 out-out out 15.671 Saltbr-out 15.758 HRD-in -86.84, -63.36 81.9, -13.38 out-out-out SNCooo out-out ActLoopNT-out 5.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -93.88, 97.75 APE9-dihe-na -63.79, 140.02 APE8-dihe-in -81.75, 121.26 APE8-rot-in 308.13 APE67-dihe-in -51.62, -26.77 -100.5, -12.72 APE12-dist-out 20.895 APE11-dist-out 16.275 APE10-dist-out 19.502 APE9-dist-out 11.054 None None None XRAY 1.9 0.205 0.242 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qqg CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QQHA 1 298 298.0 X0A:303 Type1 Inactive DFGin 10.924 16.869 BLBminus -119.07, 155.16 72.34, 39.06 -73.27, 170.06 265.1, 82.61 51.97, 3.88 out-out out 15.495 Saltbr-out 15.173 HRD-in -86.72, -61.6 84.32, -18.78 out-out-out SNCooo out-out ActLoopNT-out 5.833 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -45.62, 100.31 APE9-dihe-na -62.95, 133.96 APE8-dihe-in -80.55, 113.46 APE8-rot-in 299.01 APE67-dihe-in -52.55, -27.33 -97.79, -12.76 APE12-dist-out 20.418 APE11-dist-out 17.052 APE10-dist-out 19.573 APE9-dist-out 11.175 None None None XRAY 1.87 0.201 0.232 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qqh CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QQKA 1 298 298.0 X02:497 Type1 Inactive DFGin 7.29 15.207 BLBminus -132.47, 171.25 44.74, 61.06 -59.66, 145.15 280.16, 63.99 -55.47, -65.44 out-out out 14.956 Saltbr-out 11.911 HRD-in -83.58, -52.35 81.91, -18.93 out-out-out SNCooo out-out ActLoopNT-out 7.763 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -73.11, 113.25 APE9-dihe-na -70.31, 131.43 APE8-dihe-in -81.07, 126.63 APE8-rot-in 298.78 APE67-dihe-in -52.62, -31.22 -104.13, -2.93 APE12-dist-out 21.618 APE11-dist-out 17.304 APE10-dist-out 19.891 APE9-dist-out 11.016 None None None XRAY 1.86 0.201 0.241 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qqk CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QRTA 1 298 298.0 X14:535 Type1 Inactive DFGin 8.637 15.887 BLBminus -133.92, 161.18 62.84, 54.27 -62.7, 112.03 292.17, 73.36 -59.88, -51.96 out-out out 14.954 Saltbr-out 14.213 HRD-in -86.25, -54.44 79.97, -14.56 out-out-out SNCooo out-out ActLoopNT-out 7.749 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.55, 122.31 APE9-dihe-na -71.57, 125.05 APE8-dihe-in -76.9, 127.59 APE8-rot-in 303.44 APE67-dihe-in -55.97, -25.61 -103.81, -0.01 APE12-dist-out 22.81 APE11-dist-out 18.68 APE10-dist-out 20.407 APE9-dist-out 10.88 None None None XRAY 1.75 0.196 0.221 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qrt CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QRUA 1 298 298.0 X19:493 Type1 Inactive DFGin 8.391 15.798 BLBminus -141.58, 159.78 61.06, 51.88 -57.35, 130.19 290.87, 74.5 -92.88, 162.73 out-out out 14.922 Saltbr-out 15.362 HRD-in -84.41, -53.63 81.51, -20.18 out-out-out SNCooo out-out ActLoopNT-out 8.401 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.02, 123.48 APE9-dihe-na -77.33, 134.65 APE8-dihe-in -76.78, 129.51 APE8-rot-out 180.19 APE67-dihe-in -52.08, -29.31 -100.18, -5.68 APE12-dist-out 20.745 APE11-dist-out 18.783 APE10-dist-out 19.707 APE9-dist-out 10.878 None None None XRAY 1.95 0.2 0.236 A 306 295 3 0 0 0 [[4, 286]] 1.0 3qru CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QTQA 1 298 298.0 X35:476 Type1 Inactive DFGin 8.037 15.326 BLBminus -134.07, 169.77 50.18, 51.65 -54.92, 133.54 279.48, 69.67 -45.42, -64.6 out-out out 14.761 Saltbr-out 14.88 HRD-in -79.34, -54.03 79.9, -15.94 out-out-out SNCooo out-out ActLoopNT-out 7.832 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -70.82, 120.08 APE9-dihe-na -73.72, 128.49 APE8-dihe-in -76.92, 124.69 APE8-rot-in 293.92 APE67-dihe-in -55.38, -27.05 -99.71, -3.98 APE12-dist-out 21.47 APE11-dist-out 17.123 APE10-dist-out 19.567 APE9-dist-out 10.976 None None None XRAY 1.8 0.204 0.233 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qtq CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QTRA 1 298 298.0 X36:497 Type1 Inactive DFGin 7.991 15.109 BLBminus -135.98, 168.38 49.02, 56.34 -59.01, 137.45 280.21, 69.64 -84.87, 137.4 out-out out 15.034 Saltbr-out 11.197 HRD-in -82.64, -52.75 82.7, -20.75 out-out-out SNCooo out-out ActLoopNT-out 9.782 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -168.04 APE9-dihe-na -55.73, 122.77 APE8-dihe-in -80.55, 127.37 APE8-rot-in 308.0 APE67-dihe-in -54.76, -28.18 -106.52, -1.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.208 APE9-dist-out 11.122 None None None XRAY 1.85 0.202 0.23 A 306 282 16 0 0 8 [[4, 286]] 1.0 3qtr CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QTUA 1 298 298.0 X44:451 Type1 Inactive DFGin 8.415 15.762 BLBminus -124.2, 155.48 50.29, 63.32 -57.44, 137.74 282.91, 69.35 -85.49, -45.13 out-out out 15.01 Saltbr-out 15.118 HRD-in -83.99, -51.26 82.9, -20.21 out-out-out SNCooo out-out ActLoopNT-out 7.824 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.17, 135.28 APE9-dihe-na -107.7, 135.0 APE8-dihe-in -73.46, 136.05 APE8-rot-out 193.34 APE67-dihe-in -55.54, -26.46 -111.29, -1.07 APE12-dist-out 23.013 APE11-dist-out 19.624 APE10-dist-out 20.93 APE9-dist-out 11.339 None None None XRAY 1.82 0.195 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qtu CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QTXA 1 298 298.0 X43:299 Type1 Inactive DFGin 7.781 15.356 BLBminus -128.82, 166.52 48.57, 62.3 -60.66, 139.86 279.19, 71.31 -50.84, -58.14 out-out out 14.801 Saltbr-out 10.905 HRD-in -79.57, -50.58 79.44, -23.57 out-out-out SNCooo out-out ActLoopNT-out 7.35 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.69, 103.13 APE9-dihe-na -75.18, 127.32 APE8-dihe-in -69.63, 125.97 APE8-rot-out 179.61 APE67-dihe-in -51.99, -31.06 -102.46, -4.03 APE12-dist-out 21.447 APE11-dist-out 18.054 APE10-dist-out 20.379 APE9-dist-out 11.066 None None None XRAY 1.95 0.2 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qtx CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QTZA 1 298 298.0 X42:453 Type1 Inactive DFGin 7.768 15.278 BLBminus -133.18, 164.28 52.99, 54.75 -56.95, 134.84 279.16, 70.75 -100.74, 4.7 out-out out 15.308 Saltbr-out 15.483 HRD-in -82.14, -50.3 81.43, -21.43 out-out-out SNCooo out-out ActLoopNT-out 7.44 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -73.19, 105.13 APE9-dihe-na -65.72, 131.59 APE8-dihe-in -80.1, 127.22 APE8-rot-in 301.54 APE67-dihe-in -55.55, -28.21 -106.83, -1.58 APE12-dist-out 21.9 APE11-dist-out 17.701 APE10-dist-out 20.271 APE9-dist-out 10.957 None None None XRAY 2.0 0.202 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qtz CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QWKA 1 298 298.0 X62:493 Type1 Inactive DFGin 8.713 15.674 BLBminus -127.95, 169.35 39.64, 71.88 -70.76, 133.51 290.23, 52.56 -108.77, 49.87 out-out out 15.13 Saltbr-out 16.54 HRD-in -82.55, -56.98 83.14, -20.05 out-out-out SNCooo out-out ActLoopNT-out 8.061 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -54.72, 107.28 APE9-dihe-na -65.56, 129.36 APE8-dihe-in -81.64, 121.57 APE8-rot-in 300.12 APE67-dihe-in -54.54, -27.53 -101.43, -1.1 APE12-dist-out 21.355 APE11-dist-out 17.387 APE10-dist-out 19.844 APE9-dist-out 11.007 None None None XRAY 1.85 0.207 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qwk CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QXPA 1 298 298.0 X64:300 Type1 Inactive DFGin 7.908 15.512 BLBminus -135.49, 164.67 52.44, 57.4 -62.98, 142.61 277.98, 70.01 -96.41, 145.61 out-out out 14.496 Saltbr-out 12.22 HRD-in -83.86, -49.65 79.39, -21.07 out-out-out SNCooo out-out ActLoopNT-out 9.562 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -72.01, 118.12 APE9-dihe-na -71.58, 126.15 APE8-dihe-in -77.27, 123.66 APE8-rot-in 299.27 APE67-dihe-in -54.11, -26.26 -102.0, -3.09 APE12-dist-out 20.875 APE11-dist-out 18.066 APE10-dist-out 20.082 APE9-dist-out 11.139 None None None XRAY 1.75 0.214 0.254 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qxp CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R8MA 1 298 298.0 Z19:486 Type1 Inactive DFGin 10.989 17.31 BLBminus -122.41, 152.36 73.15, 33.34 -69.36, 151.5 255.2, 103.68 58.11, 16.63 out-out out 15.195 Saltbr-out 15.581 HRD-in -86.0, -60.77 82.89, -16.21 out-out-out SNCooo out-out ActLoopNT-out 8.467 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -69.41, 139.9 APE9-dihe-na -51.57, 140.21 APE8-dihe-in -90.73, 123.13 APE8-rot-out 182.54 APE67-dihe-in -54.59, -28.83 -98.3, -5.65 APE12-dist-none 999.0 APE11-dist-out 18.029 APE10-dist-out 19.579 APE9-dist-out 11.074 None None None XRAY 1.8 0.204 0.239 A 306 286 12 0 0 8 [[4, 286]] 1.0 3r8m CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R8ZA 1 298 298.0 Z63:440 Type1 Inactive DFGin 8.29 15.335 BLBminus -130.9, 171.61 46.81, 58.88 -55.61, 142.97 276.8, 68.48 -58.52, -18.41 out-out out 15.229 Saltbr-out 14.87 HRD-in -82.11, -54.38 81.72, -20.6 out-out-out SNCooo out-out ActLoopNT-out 6.99 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -69.62, 127.55 APE9-dihe-na -73.92, 124.12 APE8-dihe-in -77.45, 133.26 APE8-rot-in 299.5 APE67-dihe-in -56.36, -23.43 -103.04, -1.32 APE12-dist-out 21.87 APE11-dist-out 16.548 APE10-dist-out 19.318 APE9-dist-out 10.589 None None None XRAY 1.85 0.207 0.251 A 306 290 8 0 0 4 [[4, 286]] 1.0 3r8z CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RAKA 1 298 298.0 03Z:497 Type1 Inactive DFGin 8.126 15.308 BLBminus -133.09, 166.12 51.72, 55.5 -59.82, 137.01 276.67, 74.6 -91.79, 143.23 out-out out 14.823 Saltbr-out 11.516 HRD-in -85.31, -52.73 80.88, -16.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 103.47 APE9-dihe-na -66.57, 133.27 APE8-dihe-in -82.83, 126.93 APE8-rot-out 182.39 APE67-dihe-in -56.12, -27.61 -102.78, -0.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.139 APE9-dist-out 11.056 None None None XRAY 1.75 0.196 0.237 A 306 277 21 0 0 13 [[4, 286]] 1.0 3rak CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RALA 1 298 298.0 04Z:499 Type1 Inactive DFGin 7.833 15.191 BLBminus -135.51, 167.61 50.29, 56.61 -59.14, 143.27 279.01, 70.58 -92.11, 138.36 out-out out 14.777 Saltbr-out 11.523 HRD-in -83.6, -52.01 81.1, -18.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 102.73 APE9-dihe-na -64.16, 134.56 APE8-dihe-in -86.02, 129.75 APE8-rot-out 181.16 APE67-dihe-in -53.9, -28.19 -103.13, -1.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.027 APE9-dist-out 11.138 None None None XRAY 1.75 0.198 0.228 A 306 277 21 0 0 13 [[4, 286]] 1.0 3ral CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RJCA 1 298 298.0 06Z:450 Type1 Inactive DFGin 8.085 15.399 BLBminus -135.34, 172.85 50.1, 54.57 -59.13, 124.88 277.89, 69.35 -88.35, 2.88 out-out out 15.614 Saltbr-out 15.713 HRD-in -85.11, -52.42 81.91, -21.02 out-out-out SNCooo out-out ActLoopNT-out 7.293 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.28, 114.54 APE9-dihe-na -75.17, 128.02 APE8-dihe-in -83.73, 127.96 APE8-rot-in 291.59 APE67-dihe-in -52.65, -28.29 -101.57, -4.56 APE12-dist-out 21.421 APE11-dist-out 17.54 APE10-dist-out 19.72 APE9-dist-out 10.847 None None None XRAY 1.85 0.209 0.25 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rjc CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RK9A 1 298 298.0 09Z:483 Type1 Inactive DFGin 7.98 15.359 BLBminus -131.82, 170.19 48.71, 55.23 -57.8, 135.95 279.41, 67.13 -79.86, 138.97 out-out out 14.693 Saltbr-out 14.358 HRD-in -79.25, -54.85 81.34, -17.93 out-out-out SNCooo out-out ActLoopNT-out 7.96 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -56.06, 109.06 APE9-dihe-na -69.47, 134.31 APE8-dihe-in -84.22, 124.73 APE8-rot-in 298.49 APE67-dihe-in -52.39, -30.8 -101.51, -4.3 APE12-dist-out 20.403 APE11-dist-out 16.904 APE10-dist-out 19.431 APE9-dist-out 11.116 None None None XRAY 1.85 0.211 0.252 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rk9 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RMFA 1 298 298.0 20Z:496 Type1 Inactive DFGin 8.377 15.276 BLBminus -129.83, 164.82 49.28, 60.4 -59.9, 137.12 279.82, 70.96 -89.46, 127.58 out-out out 15.0 Saltbr-out 10.934 HRD-in -87.34, -53.25 82.75, -18.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 103.92 APE9-dihe-na -62.36, 129.27 APE8-dihe-in -83.67, 130.42 APE8-rot-out 183.12 APE67-dihe-in -52.19, -29.09 -107.71, -1.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.253 APE9-dist-out 11.115 None None None XRAY 1.75 0.208 0.234 A 306 278 20 0 0 13 [[4, 286]] 1.0 3rmf CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RNIA 1 298 298.0 21Z:424 Type1 Inactive DFGin 8.256 15.342 BLBminus -134.89, 174.06 47.03, 52.76 -58.91, 133.55 279.59, 61.87 -91.89, 141.62 out-out out 15.369 Saltbr-out 12.061 HRD-in -82.7, -52.66 79.11, -17.74 out-out-out SNCooo out-out ActLoopNT-out 10.134 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -50.0, 129.79 APE9-dihe-na -85.93, 123.93 APE8-dihe-in -74.63, 122.3 APE8-rot-in 297.2 APE67-dihe-in -54.32, -25.21 -102.82, -4.52 APE12-dist-out 20.344 APE11-dist-out 17.515 APE10-dist-out 19.529 APE9-dist-out 11.042 None None None XRAY 1.95 0.209 0.255 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rni CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RPVA 1 298 298.0 26Z:495 Type1 Inactive DFGin 7.864 15.361 BLBminus -129.42, 164.67 51.9, 56.84 -59.9, 141.65 276.65, 69.79 -91.4, 141.14 out-out out 14.599 Saltbr-out 11.732 HRD-in -80.32, -52.39 82.71, -20.67 out-out-out SNCooo out-out ActLoopNT-out 7.997 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -60.18, 108.94 APE9-dihe-na -73.22, 132.87 APE8-dihe-in -79.88, 128.02 APE8-rot-out 179.23 APE67-dihe-in -54.3, -28.91 -105.55, -1.25 APE12-dist-out 20.722 APE11-dist-out 17.514 APE10-dist-out 19.939 APE9-dist-out 11.059 None None None XRAY 1.8 0.204 0.239 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rpv CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RPYA 1 298 298.0 27Z:470 Type1 Inactive DFGin 8.003 15.017 BLBminus -132.06, 172.66 52.86, 48.25 -55.95, 137.26 281.19, 70.31 -87.65, 136.45 out-out out 14.644 Saltbr-out 10.284 HRD-in -81.36, -51.43 80.57, -20.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 100.77 APE9-dihe-na -61.76, 138.29 APE8-dihe-in -87.6, 129.84 APE8-rot-in 309.15 APE67-dihe-in -53.92, -30.09 -108.26, -3.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.627 APE9-dist-out 11.118 None None None XRAY 1.9 0.203 0.251 A 306 277 21 0 0 13 [[4, 286]] 1.0 3rpy CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3S1HA 1 298 298.0 56Z:479 Type1 Inactive DFGin 8.181 15.258 BLBminus -130.77, 169.31 45.06, 59.36 -59.76, 144.0 279.87, 70.72 -93.94, 139.68 out-out out 14.855 Saltbr-out 11.204 HRD-in -87.93, -51.08 80.53, -18.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 99.22 APE9-dihe-na -59.88, 137.31 APE8-dihe-in -88.14, 131.16 APE8-rot-out 181.31 APE67-dihe-in -54.25, -29.26 -105.99, -0.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.339 APE9-dist-out 11.165 None None None XRAY 1.75 0.209 0.25 A 306 277 21 0 0 13 [[4, 286]] 1.0 3s1h CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3SQQA 1 298 298.0 99Z:456 Type1 Inactive DFGin 7.727 15.493 BLBminus -133.88, 167.76 51.73, 56.7 -62.04, 141.7 276.47, 71.84 -97.5, 141.15 out-out out 14.434 Saltbr-out 11.744 HRD-in -82.77, -51.82 82.27, -21.93 out-out-out SNCooo out-out ActLoopNT-out 9.387 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -144.66, 112.47 APE9-dihe-na -74.52, 130.02 APE8-dihe-in -78.03, 123.84 APE8-rot-in 302.57 APE67-dihe-in -56.36, -26.87 -102.77, -1.64 APE12-dist-out 22.556 APE11-dist-out 17.588 APE10-dist-out 19.969 APE9-dist-out 11.006 None None None XRAY 1.85 0.204 0.236 A 306 288 10 0 0 6 [[4, 286]] 1.0 3sqq CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4ERWA 1 298 298.0 STU:301 Type1 Inactive DFGin 8.162 15.602 BLBminus -125.29, 160.66 52.47, 61.82 -60.63, 138.56 279.12, 65.63 -74.82, 135.35 out-out out 15.467 Saltbr-out 12.024 HRD-in -85.09, -48.23 77.57, -22.2 out-out-out SNCooo out-out ActLoopNT-out 9.279 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.87, 148.53 APE9-dihe-na -96.15, 140.05 APE8-dihe-in -88.42, 131.99 APE8-rot-out 198.97 APE67-dihe-in -59.72, -24.59 -102.21, -6.98 APE12-dist-out 19.529 APE11-dist-out 16.258 APE10-dist-out 18.687 APE9-dist-out 10.897 None None OCS177 XRAY 2.0 0.196 0.244 A 306 293 5 0 0 0 [[4, 286]] 1.0 4erw CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EZ3A 1 298 298.0 0S0:301 Type1 Inactive DFGin 7.853 15.267 BLBminus -133.96, 164.73 51.79, 51.75 -53.29, 139.94 283.77, 63.17 -91.21, 154.8 out-out out 15.432 Saltbr-out 11.797 HRD-in -73.94, -47.35 72.9, -19.55 out-out-out SNCooo out-out ActLoopNT-out 9.746 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.13, 71.3 APE9-dihe-na -50.77, 138.23 APE8-dihe-in -127.23, 122.97 APE8-rot-in 280.81 APE67-dihe-in -57.94, -28.97 -97.57, -11.17 APE12-dist-out 18.663 APE11-dist-out 19.324 APE10-dist-out 19.14 APE9-dist-out 11.228 None None None XRAY 2.0 0.215 0.251 A 306 294 4 0 0 0 [[4, 286]] 1.0 4ez3 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4GCJA 1 298 298.0 X64:60305 Type1 Inactive DFGin 7.48 15.445 BLBminus -128.79, 165.13 55.31, 52.44 -58.37, 140.99 280.27, 64.84 -88.27, 148.81 out-out out 14.152 Saltbr-out 11.552 HRD-in -83.59, -49.05 76.02, -17.04 out-out-out SNCooo out-out ActLoopNT-out 10.098 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -62.57, -25.33 APE9-dihe-na -58.46, -30.9 APE8-dihe-out -60.96, -28.7 APE8-rot-out 61.81 APE67-dihe-in -60.38, -24.3 -67.05, -28.87 APE12-dist-out 18.889 APE11-dist-out 15.971 APE10-dist-out 19.84 APE9-dist-out 11.54 None None None XRAY 1.42 0.192 0.205 A 306 298 0 0 0 0 [[4, 286]] 1.0 4gcj CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6GUHA 1 298 298.0 FB8:60301 Type1 Inactive DFGin 8.694 15.809 BLBminus -120.04, 173.52 62.61, 46.47 -54.07, 136.17 282.54, 69.51 -112.2, 71.47 out-out out 15.464 Saltbr-out 12.084 HRD-in -84.89, -57.05 82.23, -6.91 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.39, 131.44 APE9-dihe-na -74.39, 131.26 APE8-dihe-in -71.45, 137.64 APE8-rot-out 183.41 APE67-dihe-in -63.46, -27.01 -101.58, -1.17 APE12-dist-out 19.956 APE11-dist-out 18.042 APE10-dist-out 18.112 APE9-dist-out 10.263 None None None XRAY 1.5 0.201 0.243 A 306 282 16 0 0 8 [[4, 286]] 1.0 6guh CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4D1ZA 3 295 298.0 WG8:1296,WG8:1297 Type1,Allosteric Inactive DFGin 7.655 14.879 BLBminus -138.61, 166.7 53.69, 62.06 -66.35, 146.31 289.12, 61.98 -62.67, 999.0 out-none out 14.426 Saltbr-none 999.0 HRD-in -87.85, -51.36 68.31, -11.6 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -158.52 APE8-rot-in 317.6 APE67-dihe-in -61.54, -25.97 -87.85, -20.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.851 0.195 0.225 A 298 258 35 0 0 17 [[4, 286]] 1.0 4d1z CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5FP5A 1 295 298.0 1Y6:1297,1Y6:1298 Type1,Allosteric Inactive DFGin 7.106 15.112 BLBminus -126.43, 168.67 54.32, 57.13 -56.03, 146.66 281.91, 70.26 -71.22, 108.53 out-none out 14.153 Saltbr-none 999.0 HRD-in -75.97, -52.64 80.13, -21.84 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -61.4 APE8-rot-in 287.38 APE67-dihe-in -57.93, -29.61 -103.75, -5.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.16 0.19 0.253 A 298 264 31 0 0 16 [[4, 286]] 1.0 5fp5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5FP6A 1 294 298.0 MFZ:1295,MFZ:1296 Type1,Allosteric Inactive DFGin 7.159 14.886 BLBminus -139.17, 164.12 57.45, 56.83 -61.36, 140.84 280.63, 65.35 -62.28, 999.0 out-out out 14.255 Saltbr-out 12.885 HRD-in -71.27, -54.68 83.61, -20.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 114.0 APE8-dihe-in -82.84, 129.07 APE8-rot-in 309.53 APE67-dihe-in -59.66, -27.11 -102.64, -3.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.329 None None None XRAY 1.85 0.209 0.24 A 298 278 16 0 0 16 [[4, 286]] 1.0 5fp6 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3PXQA 1 298 298.0 2AN:60300,2AN:60301,2AN:60302 Type1,Allosteric,Type3 Inactive DFGin 6.791 14.958 BLBminus -156.11, 172.24 56.44, 48.4 -58.19, 145.75 280.77, 74.71 -81.02, -171.95 out-out out 17.021 Saltbr-out 15.6 HRD-in -85.93, -53.84 79.73, -15.83 out-out-out SNCooo out-out ActLoopNT-out 10.14 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -155.6, 50.43 APE9-dihe-na -145.4, -64.21 APE8-dihe-out -61.58, -25.66 APE8-rot-out 171.8 APE67-dihe-in -58.56, -25.05 -69.11, -27.97 APE12-dist-out 16.567 APE11-dist-out 17.761 APE10-dist-out 20.389 APE9-dist-out 11.311 None None None XRAY 1.9 0.196 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3pxq CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3PY1A 1 298 298.0 SU9:60300,2AN:60301,2AN:60302 Type1,Allosteric,Type3 Inactive DFGin 6.969 14.582 BLBminus -156.43, 165.09 55.84, 55.34 -63.31, 145.25 285.83, 75.03 -95.3, 141.59 out-out out 15.677 Saltbr-out 11.464 HRD-in -77.3, -51.37 78.87, -23.11 out-out-out SNCooo out-out ActLoopNT-out 9.408 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -116.77, -56.62 APE9-dihe-na -53.47, -37.91 APE8-dihe-out -53.54, -42.42 APE8-rot-in 292.43 APE67-dihe-in -55.86, -28.72 -53.35, -38.93 APE12-dist-in 11.889 APE11-dist-out 15.747 APE10-dist-out 18.483 APE9-dist-out 10.674 None None None XRAY 2.05 0.199 0.251 A 306 298 0 0 0 0 [[4, 286]] 1.0 3py1 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7RWEA 3 298 298.0 7TH:301,7TH:302 Type1,Type3 Inactive DFGin 9.525 14.836 BLBminus -143.06, 174.7 57.85, 50.81 -63.66, 150.13 280.61, 73.06 -93.43, 46.42 none-none none 999.0 Saltbr-none 999.0 HRD-in -84.43, -53.97 80.54, -19.03 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -28.29 APE8-rot-out 191.2 APE67-dihe-in -60.45, -24.39 -100.07, -4.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.59 0.217 0.238 A 298 254 42 0 0 16 [[4, 286]] 1.0 7rwe CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7SA0A 1 298 298.0 8KQ:305,8KQ:306 Type1,Type3 Inactive DFGin 9.605 14.534 BLBminus -154.45, 170.89 59.18, 53.24 -66.44, 148.13 286.95, 61.45 -96.89, 60.62 out-out out 16.349 Saltbr-out 16.233 HRD-in -77.47, -50.62 78.26, -17.98 out-out-out SNCooo out-out ActLoopNT-out 9.355 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 141.94 APE9-dihe-na -88.84, 132.94 APE8-dihe-in -88.27, 121.95 APE8-rot-in 299.98 APE67-dihe-in -59.38, -26.65 -102.3, 0.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.68 APE9-dist-out 11.048 None None None XRAY 1.59 0.196 0.219 A 298 281 17 0 0 6 [[4, 286]] 1.0 7sa0 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8FOWA 3 298 298.0 1QK:303,7TW:304 Type1,Type3 Inactive DFGin 9.603 14.684 BLBminus -142.98, 169.57 62.58, 46.02 -58.43, 140.27 285.17, 73.33 -80.44, 47.06 out-out out 16.793 Saltbr-out 17.874 HRD-in -84.61, -56.26 85.39, -14.19 out-out-out SNCooo out-out ActLoopNT-out 9.539 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -79.82, 130.93 APE9-dihe-na -70.75, 142.04 APE8-dihe-in -94.51, 122.37 APE8-rot-in 301.96 APE67-dihe-in -61.63, -23.3 -100.31, -0.74 APE12-dist-none 999.0 APE11-dist-out 19.404 APE10-dist-out 20.622 APE9-dist-out 10.975 None None None XRAY 1.6 0.205 0.221 A 298 275 21 0 0 9 [[4, 286]] 1.0 8fow CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8FP0A 2 298 298.0 RRC:303,7TW:304 Type1,Type3 Inactive DFGin 9.391 14.948 BLBminus -136.63, 174.45 61.03, 42.96 -56.03, 146.23 280.88, 71.31 -87.4, 49.07 out-out out 16.002 Saltbr-out 16.492 HRD-in -87.02, -54.08 75.17, -13.79 out-out-out SNCooo out-out ActLoopNT-out 9.594 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 140.67 APE9-dihe-na -85.45, 141.48 APE8-dihe-in -84.73, 120.79 APE8-rot-in 296.72 APE67-dihe-in -62.27, -23.72 -95.92, -2.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.323 APE9-dist-out 10.967 None None None XRAY 1.6 0.213 0.24 A 298 274 23 0 0 11 [[4, 286]] 1.0 8fp0 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EZ7A 1 298 298.0 STU:60301,2AN:60302,2AN:60303 Type1,Type3,Allosteric Inactive DFGin 6.978 14.625 BLBminus -145.53, 170.39 52.9, 57.73 -61.57, 149.9 287.28, 68.06 -86.96, 168.33 out-out out 16.748 Saltbr-out 14.413 HRD-in -86.07, -42.21 71.45, -15.9 out-out-out SNCooo out-out ActLoopNT-out 10.236 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -63.47, 156.15 APE9-dihe-na -125.23, 14.23 APE8-dihe-out -63.17, -28.79 APE8-rot-in 293.42 APE67-dihe-in -53.71, -31.99 -57.23, -35.61 APE12-dist-out 18.472 APE11-dist-out 18.425 APE10-dist-out 13.977 APE9-dist-out 11.306 None None None XRAY 2.49 0.22 0.274 A 306 298 0 0 0 0 [[4, 286]] 1.0 4ez7 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7RXOA 3 298 298.0 80E:302 Type3 Inactive DFGin 9.577 15.209 BLBminus -139.06, 169.7 61.6, 49.36 -60.15, 142.75 280.94, 71.13 -90.17, 55.28 out-none out 16.257 Saltbr-none 999.0 HRD-in -84.07, -54.4 80.78, -17.71 none-out-out SNCnoo out-out ActLoopNT-out 9.285 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 128.7 APE9-dihe-na -79.88, 129.58 APE8-dihe-in -82.74, 122.09 APE8-rot-in 299.53 APE67-dihe-in -61.07, -23.59 -103.49, 0.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.234 APE9-dist-out 11.072 None None None XRAY 1.38 0.221 0.233 A 298 266 30 0 0 11 [[4, 286]] 1.0 7rxo CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7S4TA 3 298 298.0 88O:302 Type3 Inactive DFGin 9.489 14.93 BLBminus -139.75, 172.37 54.85, 54.18 -61.18, 140.99 279.06, 68.96 -88.85, 55.03 out-out out 16.133 Saltbr-out 17.267 HRD-in -83.62, -51.24 80.26, -20.24 out-out-out SNCooo out-out ActLoopNT-out 9.773 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.14, 114.43 APE9-dihe-na -104.15, 134.39 APE8-dihe-in -80.41, 117.61 APE8-rot-in 297.25 APE67-dihe-in -59.04, -28.55 -98.31, -2.72 APE12-dist-out 21.83 APE11-dist-out 15.938 APE10-dist-out 19.475 APE9-dist-out 10.954 None None None XRAY 1.91 0.176 0.218 A 298 293 3 0 0 0 [[4, 286]] 1.0 7s4t CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7S7AA 2 298 298.0 8FI:302 Type3 Inactive DFGin 9.329 14.863 BLBminus -135.89, 169.74 57.4, 53.57 -62.05, 140.1 280.75, 73.98 -88.85, 60.5 out-none out 16.295 Saltbr-none 999.0 HRD-in -83.29, -52.56 81.61, -18.34 none-out-out SNCnoo out-out ActLoopNT-out 9.519 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 134.88 APE9-dihe-na -76.39, 137.86 APE8-dihe-in -88.45, 118.46 APE8-rot-in 298.52 APE67-dihe-in -62.81, -25.13 -99.02, 0.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.232 APE9-dist-out 11.121 None None None XRAY 1.7 0.207 0.238 A 298 278 19 0 0 6 [[4, 286]] 1.0 7s7a CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7S84A 1 298 298.0 8IL:301 Type3 Inactive DFGin 9.497 14.909 BLBminus -138.52, 170.26 59.0, 52.71 -61.4, 138.63 280.38, 69.16 -88.44, 57.68 out-out out 16.574 Saltbr-out 16.91 HRD-in -84.23, -49.7 77.31, -14.87 out-out-out SNCooo out-out ActLoopNT-out 9.341 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 132.74 APE9-dihe-na -86.51, 133.78 APE8-dihe-in -79.23, 128.57 APE8-rot-in 299.16 APE67-dihe-in -62.27, -25.49 -106.32, 3.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.695 APE9-dist-out 10.85 None None None XRAY 2.0 0.2 0.244 A 298 282 16 0 0 6 [[4, 286]] 1.0 7s84 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7S85A 3 298 298.0 8IQ:303 Type3 Inactive DFGin 9.781 15.144 BLBminus -134.14, 169.78 58.04, 49.92 -58.53, 139.92 281.4, 68.84 -85.04, 54.66 out-out out 16.939 Saltbr-out 18.208 HRD-in -87.86, -51.53 80.52, -16.15 out-out-out SNCooo out-out ActLoopNT-out 9.384 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 138.57 APE9-dihe-na -72.34, 136.21 APE8-dihe-in -90.62, 126.85 APE8-rot-in 294.4 APE67-dihe-in -60.51, -24.54 -104.08, -3.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.471 APE9-dist-out 10.828 None None None XRAY 1.98 0.208 0.252 A 298 281 15 0 0 6 [[4, 286]] 1.0 7s85 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7S9XA 3 298 298.0 8KF:301 Type3 Inactive DFGin 9.152 14.904 BLBminus -140.51, 174.83 55.24, 52.61 -60.52, 155.06 283.44, 65.83 -96.54, 51.03 out-out out 17.021 Saltbr-out 17.405 HRD-in -80.98, -57.39 84.63, -18.55 out-out-out SNCooo out-out ActLoopNT-out 9.299 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 131.76 APE9-dihe-na -82.0, 133.39 APE8-dihe-in -82.83, 123.04 APE8-rot-in 299.71 APE67-dihe-in -59.76, -23.84 -102.49, -0.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.12 APE9-dist-out 11.022 None None None XRAY 1.69 0.231 0.262 A 298 269 27 0 0 12 [[4, 286]] 1.0 7s9x CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7RWFA 1 298 298.0 7TW:60302 Type3 Inactive DFGin 9.475 14.851 BLBminus -140.11, 174.11 55.01, 51.54 -61.58, 141.11 278.46, 73.02 -87.62, 59.54 out-out out 16.189 Saltbr-out 17.439 HRD-in -86.88, -54.95 86.13, -18.41 out-out-out SNCooo out-out ActLoopNT-out 9.866 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -106.87, 114.93 APE9-dihe-na -103.6, 143.12 APE8-dihe-in -86.24, 120.37 APE8-rot-in 298.57 APE67-dihe-in -60.28, -26.78 -101.29, -1.63 APE12-dist-out 21.854 APE11-dist-out 16.026 APE10-dist-out 19.464 APE9-dist-out 10.963 None None None XRAY 1.5 0.193 0.209 A 299 298 0 0 0 0 [[4, 286]] 1.0 7rwf CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7UG1A 1 295 298.0 N5R:60301,N5R:60302 Type3,Allosteric Inactive DFGin 6.692 15.049 BLBminus -154.93, 172.78 49.62, 54.28 -54.44, 144.52 289.06, 72.65 -89.13, 27.85 out-out out 17.046 Saltbr-out 15.958 HRD-in -81.96, -54.91 81.92, -12.71 out-out-out SNCooo out-out ActLoopNT-out 10.411 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -76.84, -22.46 APE9-dihe-na -57.42, -34.71 APE8-dihe-out -59.79, -32.24 APE8-rot-in 307.27 APE67-dihe-in -63.21, -23.7 -63.64, -31.65 APE12-dist-none 999.0 APE11-dist-out 15.205 APE10-dist-out 19.426 APE9-dist-out 11.354 None None None XRAY 1.84 0.185 0.242 A 306 286 9 0 0 3 [[4, 286]] 1.0 7ug1 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKUA 1 298 298.0 60K:60301,60K:60303 Allosteric,Type1 Inactive DFGin 7.532 14.657 BLBplus -135.21, 172.93 58.37, 56.18 -149.13, 168.21 70.31, 113.83 101.63, -8.92 out-out out 14.86 Saltbr-out 13.98 HRD-in -76.61, -52.96 81.36, -19.81 out-out-out SNCooo out-out ActLoopNT-out 9.027 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -122.19, 109.72 APE9-dihe-na -67.24, 137.07 APE8-dihe-in -92.16, 118.49 APE8-rot-in 298.26 APE67-dihe-in -57.53, -28.86 -100.6, -4.39 APE12-dist-out 20.495 APE11-dist-out 16.094 APE10-dist-out 20.291 APE9-dist-out 11.164 None None None XRAY 1.47 0.165 0.192 A 299 293 5 0 0 0 [[4, 286]] 1.0 4fku CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1AQ1A 1 298 298.0 STU:299 Type1 Inactive DFGin 7.283 14.934 BLBplus -138.32, 166.15 50.99, 60.93 -140.99, 149.68 67.4, 106.52 86.86, 1.1 out-out out 14.888 Saltbr-out 13.171 HRD-in -84.88, -53.74 82.51, -14.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -59.57, 119.45 APE9-dihe-na -86.87, 141.05 APE8-dihe-in -59.86, 138.54 APE8-rot-out 207.57 APE67-dihe-in -54.1, -30.89 -108.21, -4.5 APE12-dist-none 999.0 APE11-dist-out 16.32 APE10-dist-out 19.124 APE9-dist-out 10.677 None None None XRAY 2.0 0.22 0.26 A 298 277 21 0 0 13 [[4, 286]] 1.0 1aq1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1DI8A 1 298 298.0 DTQ:500 Type1 Inactive DFGin 5.286 12.815 BLBplus -114.54, 155.43 79.27, -0.34 -51.17, 128.46 67.78, 108.22 78.05, -4.2 out-out out 14.831 Saltbr-out 16.347 HRD-in -89.04, -65.58 89.71, -9.68 out-out-out SNCooo out-out ActLoopNT-out 5.844 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -63.21, 81.66 APE9-dihe-na -97.7, 112.93 APE8-dihe-in -52.76, 126.46 APE8-rot-out 188.18 APE67-dihe-in -53.72, -28.56 -112.91, 0.13 APE12-dist-none 999.0 APE11-dist-out 21.044 APE10-dist-out 21.004 APE9-dist-out 11.421 None None None XRAY 2.2 0.186 0.226 A 298 283 15 0 0 9 [[4, 286]] 1.0 1di8 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1FVTA 1 298 298.0 106:299 Type1 Inactive DFGin 5.142 12.898 BLBplus -112.17, 152.94 73.61, 11.22 -57.79, 138.21 65.33, 93.15 69.94, -6.82 out-out out 14.813 Saltbr-out 15.811 HRD-in -87.32, -48.04 73.21, -21.25 out-out-out SNCooo out-out ActLoopNT-out 5.65 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 116.82 APE9-dihe-na -59.95, 148.18 APE8-dihe-in -91.54, 131.39 APE8-rot-in 296.01 APE67-dihe-in -50.93, -28.82 -107.79, -3.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.112 APE9-dist-out 11.11 None None None XRAY 2.2 0.195 0.232 A 298 282 16 0 0 9 [[4, 286]] 1.0 1fvt CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1GIHA 1 298 298.0 1PU:501 Type1 Inactive DFGin 7.603 14.666 BLBplus -132.39, 162.96 73.36, 36.64 -132.47, -179.37 76.86, 142.71 79.81, -17.33 out-out out 14.516 Saltbr-out 16.918 HRD-in -84.83, -56.79 80.14, -22.26 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -3.67 APE8-dihe-in -88.7, 144.41 APE8-rot-out 81.32 APE67-dihe-in -36.89, -39.25 -93.08, -14.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.709 None None None XRAY 2.8 0.221 0.275 A 298 276 22 0 0 14 [[4, 286]] 1.0 1gih CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1JVPP 1 298 298.0 89E:301 Type1 Inactive DFGin 6.673 15.538 BLBplus -124.6, 163.56 49.59, 52.57 -127.98, 161.66 85.8, 105.57 78.71, -9.93 out-out out 15.017 Saltbr-out 13.886 HRD-in -86.56, -53.81 82.69, -21.84 out-out-out SNCooo out-out ActLoopNT-out 5.869 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 128.75 APE9-dihe-na -80.44, 132.95 APE8-dihe-in -77.78, 136.22 APE8-rot-out 187.76 APE67-dihe-in -50.97, -31.59 -104.41, -2.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.42 APE9-dist-out 10.814 None None None XRAY 1.53 0.215 0.253 P 298 281 17 0 0 10 [[4, 286]] 1.0 1jvp CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1KE5A 1 298 298.0 LS1:299 Type1 Inactive DFGin 4.799 12.605 BLBplus -119.03, 152.59 68.54, 27.6 -68.18, 143.84 65.51, 82.78 56.33, 8.79 out-out out 14.767 Saltbr-out 16.809 HRD-in -89.54, -69.21 83.16, 3.85 out-out-out SNCooo out-out ActLoopNT-out 5.89 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 128.52 APE9-dihe-na -65.15, 148.86 APE8-dihe-in -84.49, 130.69 APE8-rot-in 301.9 APE67-dihe-in -55.05, -28.17 -106.93, 2.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.158 APE9-dist-out 10.822 None None None XRAY 2.2 0.184 0.224 A 298 281 17 0 0 10 [[4, 286]] 1.0 1ke5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1KE6A 1 298 298.0 LS2:299 Type1 Inactive DFGin 5.226 13.052 BLBplus -114.43, 150.83 81.73, 9.56 -58.76, 131.87 64.85, 102.26 77.93, -15.8 out-out out 15.124 Saltbr-out 16.662 HRD-in -91.16, -66.31 93.51, -11.95 out-out-out SNCooo out-out ActLoopNT-out 5.857 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 118.37 APE8-dihe-in -78.91, 126.34 APE8-rot-in 303.73 APE67-dihe-in -51.88, -29.76 -108.1, 0.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.21 None None None XRAY 2.0 0.191 0.222 A 298 280 18 0 0 11 [[4, 286]] 1.0 1ke6 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1KE7A 1 298 298.0 LS3:299 Type1 Inactive DFGin 5.336 13.1 BLBplus -114.06, 154.6 70.77, 22.75 -68.97, 139.15 60.3, 92.81 71.56, -3.62 out-out out 15.032 Saltbr-out 16.506 HRD-in -94.13, -53.18 77.0, -19.46 out-out-out SNCooo out-out ActLoopNT-out 5.788 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 87.05 APE9-dihe-na -68.48, 130.37 APE8-dihe-in -76.61, 129.99 APE8-rot-out 186.24 APE67-dihe-in -51.76, -28.63 -110.76, -2.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.31 APE9-dist-out 11.271 None None None XRAY 2.0 0.191 0.235 A 298 281 17 0 0 10 [[4, 286]] 1.0 1ke7 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1KE8A 1 298 298.0 LS4:299 Type1 Inactive DFGin 5.502 12.634 BLBplus -115.96, 152.64 68.02, 23.95 -65.53, 134.94 55.59, 92.86 71.55, -0.07 out-out out 14.834 Saltbr-out 15.808 HRD-in -84.69, -51.99 78.68, -23.24 out-out-out SNCooo out-out ActLoopNT-out 5.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 116.25 APE9-dihe-na -82.17, 139.92 APE8-dihe-in -83.24, 126.04 APE8-rot-in 300.66 APE67-dihe-in -48.32, -30.5 -104.98, -2.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.11 APE9-dist-out 11.26 None None None XRAY 2.0 0.187 0.228 A 298 282 16 0 0 9 [[4, 286]] 1.0 1ke8 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1KE9A 1 298 298.0 LS5:299 Type1 Inactive DFGin 5.06 12.815 BLBplus -114.57, 155.42 79.31, -0.37 -51.24, 128.45 67.72, 108.23 78.07, -4.16 out-out out 14.388 Saltbr-out 16.019 HRD-in -80.91, -55.23 86.3, -14.41 out-out-out SNCooo out-out ActLoopNT-out 5.727 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 130.15 APE9-dihe-na -79.86, 152.62 APE8-dihe-in -95.68, 120.36 APE8-rot-out 190.48 APE67-dihe-in -52.61, -32.69 -98.66, 3.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.477 APE9-dist-out 11.242 None None None XRAY 2.0 0.203 0.238 A 298 281 17 0 0 10 [[4, 286]] 1.0 1ke9 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1R78A 1 298 298.0 FMD:299 Type1 Inactive DFGin 7.977 14.518 BLBplus -148.21, 162.41 66.71, 48.29 -146.21, 177.7 71.71, 111.12 103.56, 999.0 out-out out 14.502 Saltbr-out 13.771 HRD-in -74.45, -50.27 81.95, -22.67 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 130.68 APE8-dihe-in -91.04, 127.22 APE8-rot-in 297.81 APE67-dihe-in -58.04, -29.23 -104.59, -4.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.064 None None None XRAY 2.0 0.22 0.262 A 298 273 25 0 0 16 [[4, 286]] 1.0 1r78 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2XNBA 1 298 298.0 Y8L:1299 Type1 Inactive DFGin 7.51 14.957 BLBplus -137.53, 161.98 73.43, 53.28 -152.53, 158.55 82.97, 106.55 81.74, -19.61 out-out out 14.788 Saltbr-out 15.928 HRD-in -73.91, -57.47 85.82, -18.04 out-out-out SNCooo out-out ActLoopNT-out 6.607 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -79.88, 155.13 APE9-dihe-na -77.91, 135.78 APE8-dihe-in -83.69, 127.06 APE8-rot-out 190.84 APE67-dihe-in -59.57, -24.22 -99.23, -8.0 APE12-dist-out 20.35 APE11-dist-out 17.997 APE10-dist-out 19.307 APE9-dist-out 10.95 None None None XRAY 1.85 0.216 0.294 A 298 296 2 0 0 0 [[4, 286]] 1.0 2xnb CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4BGHA 1 298 298.0 3I6:1001 Type1 Inactive DFGin 8.718 15.546 BLBplus -115.48, 148.97 82.94, 18.88 -106.55, 167.4 59.8, 171.47 69.4, -14.32 out-out out 14.883 Saltbr-out 14.265 HRD-in -82.41, -56.62 80.05, -25.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 2.36 APE8-dihe-in -96.87, 115.8 APE8-rot-in 284.55 APE67-dihe-in -67.24, -23.77 -97.37, -4.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.262 None None None XRAY 1.95 0.196 0.246 A 298 275 23 0 0 14 [[4, 286]] 1.0 4bgh CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5IEVA 1 298 298.0 R0N:1001 Type1 Inactive DFGin 7.701 14.63 BLBplus -126.88, 158.29 69.51, 57.97 -153.39, -177.6 66.12, 119.16 64.78, -27.02 out-out out 14.55 Saltbr-out 14.279 HRD-in -85.43, -53.53 78.87, -18.3 out-out-out SNCooo out-out ActLoopNT-out 6.09 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 123.47 APE9-dihe-na -63.42, 141.42 APE8-dihe-in -85.25, 137.97 APE8-rot-in 326.09 APE67-dihe-in -61.55, -27.86 -107.7, -2.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.534 APE9-dist-out 10.856 None None None XRAY 2.03 0.198 0.262 A 298 284 14 0 0 9 [[4, 286]] 1.0 5iev CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKWA 1 298 298.0 62K:60301 Type1 Inactive DFGin 7.407 14.925 BLBplus -134.06, 170.99 59.77, 52.01 -144.58, 164.63 70.25, 114.29 98.79, 11.08 out-out out 14.727 Saltbr-out 11.662 HRD-in -78.53, -55.5 82.7, -17.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 129.05 APE9-dihe-na -67.36, 128.3 APE8-dihe-in -82.55, 130.77 APE8-rot-out 182.78 APE67-dihe-in -59.58, -25.87 -102.67, -2.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.458 APE9-dist-out 10.895 None None None XRAY 1.8 0.179 0.204 A 299 280 18 0 0 13 [[4, 286]] 1.0 4fkw CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7NVQA 1 294 298.0 STU:301 Type1 Inactive DFGin 7.026 14.701 BLBplus -138.98, 166.91 60.92, 69.03 -161.06, 162.59 72.07, 108.19 128.48, -14.92 out-out out 14.351 Saltbr-out 15.166 HRD-in -80.38, -55.15 83.91, -13.55 out-out-out SNCooo out-out ActLoopNT-out 6.029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.14, 127.57 APE9-dihe-na -77.4, 113.59 APE8-dihe-in -55.3, 141.9 APE8-rot-out 195.1 APE67-dihe-in -55.26, -27.26 -100.43, -4.92 APE12-dist-out 18.864 APE11-dist-out 17.703 APE10-dist-out 18.976 APE9-dist-out 9.89 None None None XRAY 2.05 0.24 0.288 A 300 287 7 0 0 0 [[4, 286]] 1.0 7nvq CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q4HA 1 298 298.0 HGH:60301 Type1 Inactive DFGin 5.848 13.451 BLBplus -107.05, 150.63 79.69, 19.7 -54.54, 140.34 50.81, 86.9 78.39, -11.53 out-out out 15.502 Saltbr-out 17.114 HRD-in -89.07, -67.36 89.36, -8.71 out-out-out SNCooo out-out ActLoopNT-out 5.907 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.62, 117.7 APE9-dihe-na -72.78, 143.88 APE8-dihe-in -90.48, 138.99 APE8-rot-out 189.01 APE67-dihe-in -63.59, -22.28 -100.99, -4.64 APE12-dist-out 18.171 APE11-dist-out 17.448 APE10-dist-out 20.035 APE9-dist-out 11.057 None None None XRAY 1.0 0.192 0.207 A 306 290 8 0 0 2 [[4, 286]] 1.0 6q4h CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1GIIA 1 298 298.0 1PU:501 Type1 Inactive DFGin 4.936 13.987 BLBplus -114.59, 156.0 67.87, 18.02 -73.98, 143.78 77.53, 108.5 80.6, -16.5 out-out out 14.793 Saltbr-out 13.858 HRD-in -88.83, -52.17 77.18, -13.7 out-out-out SNCooo out-out ActLoopNT-out 5.816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 96.29 APE8-dihe-in -79.17, 128.38 APE8-rot-out 67.02 APE67-dihe-in -53.29, -28.99 -103.74, 0.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.34 F82H,L83V,K89T None None XRAY 2.0 0.214 0.259 A 298 279 19 0 0 11 [[4, 286]] 1.0 1gii CMGC_CDK2_HUMAN CMGC 4e-89 305.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1HCKA 1 298 298.0 ATP:400 ATPlike Inactive DFGin 10.521 18.374 BLBtrans -101.64, 156.72 59.01, 28.24 -65.02, 120.2 217.92, 114.75 87.03, -4.22 out-out out 14.886 Saltbr-out 16.602 HRD-in -89.06, -54.55 70.31, -1.71 out-out-out SNCooo out-out ActLoopNT-out 5.768 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.61, 130.9 APE9-dihe-na -79.22, 142.0 APE8-dihe-in -76.12, 133.01 APE8-rot-out 180.79 APE67-dihe-in -48.4, -27.96 -101.36, -7.62 APE12-dist-out 20.077 APE11-dist-out 17.599 APE10-dist-out 19.471 APE9-dist-out 11.031 None None None XRAY 1.9 0.185 0.272 A 298 294 4 0 0 0 [[4, 286]] 1.0 1hck CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8FP5A 2 298 298.0 ATP:302 ATPlike Inactive DFGin 10.376 18.32 BLBtrans -107.51, 151.36 65.27, 30.62 -67.28, 128.54 213.84, 133.39 81.57, 1.02 out-out out 15.796 Saltbr-out 15.873 HRD-in -85.24, -57.92 82.57, -13.18 out-out-out SNCooo out-out ActLoopNT-out 5.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.36, 136.98 APE9-dihe-na -71.53, 131.08 APE8-dihe-in -77.4, 124.67 APE8-rot-in 308.71 APE67-dihe-in -62.7, -24.4 -97.59, -2.61 APE12-dist-out 20.412 APE11-dist-out 17.362 APE10-dist-out 19.075 APE9-dist-out 10.919 None None None XRAY 1.7 0.196 0.23 A 298 288 9 0 0 0 [[4, 286]] 1.0 8fp5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1B38A 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.197 18.302 BLBtrans -95.65, 156.45 60.68, 25.9 -58.03, 132.69 221.26, 95.46 85.91, -14.49 out-out out 15.154 Saltbr-out 16.064 HRD-in -76.6, -58.97 89.85, -20.78 out-out-out SNCooo out-out ActLoopNT-out 6.207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.95, 142.89 APE9-dihe-na -75.18, 129.36 APE8-dihe-in -71.98, 129.31 APE8-rot-out 193.64 APE67-dihe-in -51.99, -31.61 -101.67, -5.99 APE12-dist-out 19.553 APE11-dist-out 17.458 APE10-dist-out 18.673 APE9-dist-out 10.568 None None None XRAY 2.0 0.18 0.25 A 299 290 8 0 0 0 [[4, 286]] 1.0 1b38 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1B39A 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.534 18.343 BLBtrans -101.01, 147.7 73.19, 23.92 -63.93, 137.58 224.37, 103.76 85.74, -27.62 out-out out 15.412 Saltbr-out 16.029 HRD-in -84.44, -53.29 77.56, -15.37 out-out-out SNCooo out-out ActLoopNT-out 5.843 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.65, 122.32 APE9-dihe-na -57.75, 145.92 APE8-dihe-in -67.9, 142.03 APE8-rot-in 290.02 APE67-dihe-in -56.66, -23.98 -105.17, -10.65 APE12-dist-out 20.463 APE11-dist-out 17.183 APE10-dist-out 18.313 APE9-dist-out 9.98 None None None XRAY 2.1 0.2 0.27 A 299 290 8 0 0 0 [[4, 286]] 1.0 1b39 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5OO0A 2 296 298.0 9YZ:301 Allosteric Inactive DFGin 10.457 18.421 BLBtrans -98.86, 154.5 60.87, 27.1 -63.86, 132.51 222.63, 103.78 86.16, -13.27 out-out out 14.661 Saltbr-out 16.591 HRD-in -82.2, -54.82 78.14, -18.7 out-out-out SNCooo out-out ActLoopNT-out 5.703 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.51, 127.66 APE9-dihe-na -78.68, 130.19 APE8-dihe-in -67.86, 144.18 APE8-rot-out 191.22 APE67-dihe-in -63.77, -22.59 -100.18, -3.24 APE12-dist-out 20.036 APE11-dist-out 17.221 APE10-dist-out 18.633 APE9-dist-out 10.38 None None None XRAY 1.6 0.173 0.2 A 303 288 7 0 0 0 [[4, 286]] 1.0 5oo0 CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5OSJA 2 296 298.0 AAK:301 Allosteric Inactive DFGin 10.262 18.325 BLBtrans -96.78, 154.16 61.83, 29.6 -66.16, 131.95 219.32, 104.55 85.52, -9.85 out-out out 14.693 Saltbr-out 16.555 HRD-in -84.36, -57.66 76.18, -13.83 out-out-out SNCooo out-out ActLoopNT-out 5.767 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.05, 127.74 APE9-dihe-na -72.89, 127.71 APE8-dihe-in -65.8, 143.08 APE8-rot-out 186.25 APE67-dihe-in -65.51, -22.32 -100.61, 0.36 APE12-dist-out 19.811 APE11-dist-out 17.041 APE10-dist-out 18.542 APE9-dist-out 10.289 None None None XRAY 1.83 0.176 0.222 A 303 292 3 0 0 0 [[4, 286]] 1.0 5osj CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q4KA 1 298 298.0 HHW:60301,HHW:60302 Allosteric,Allosteric Inactive DFGin 10.85 18.405 BLBtrans -100.94, 152.22 71.23, 23.51 -58.99, 137.46 230.56, 102.4 82.0, -6.89 out-out out 15.516 Saltbr-out 17.325 HRD-in -93.17, -61.28 82.46, -13.93 out-out-out SNCooo out-out ActLoopNT-out 5.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.6, 127.33 APE9-dihe-na -72.76, 126.49 APE8-dihe-in -63.97, 143.12 APE8-rot-out 188.4 APE67-dihe-in -64.71, -25.73 -99.22, -3.26 APE12-dist-out 20.235 APE11-dist-out 17.578 APE10-dist-out 18.91 APE9-dist-out 10.441 None None None XRAY 1.06 0.144 0.162 A 306 291 7 0 0 0 [[4, 286]] 1.0 6q4k CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1HCLA 1 298 298.0 No_ligand No_ligand Inactive DFGin 10.261 18.478 BLBtrans -104.5, 152.92 61.36, 30.37 -66.41, 137.4 214.32, 108.69 78.71, -14.68 out-out out 14.93 Saltbr-out 17.86 HRD-in -93.43, -53.59 75.7, -9.41 out-out-out SNCooo out-out ActLoopNT-out 5.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.87, 124.84 APE9-dihe-na -69.95, 134.14 APE8-dihe-in -65.28, 137.06 APE8-rot-out 199.1 APE67-dihe-in -50.97, -34.09 -101.34, -6.77 APE12-dist-out 20.549 APE11-dist-out 17.533 APE10-dist-out 19.298 APE9-dist-out 10.68 None None None XRAY 1.8 0.181 0.254 A 298 294 4 0 0 0 [[4, 286]] 1.0 1hcl CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PW2A 1 298 298.0 No_ligand No_ligand Inactive DFGin 10.605 18.352 BLBtrans -101.46, 154.65 61.28, 26.58 -64.34, 136.96 219.75, 106.07 77.58, -3.2 out-out out 15.033 Saltbr-out 16.455 HRD-in -88.6, -57.54 84.26, -15.45 out-out-out SNCooo out-out ActLoopNT-out 5.933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.82, 124.17 APE9-dihe-na -70.75, 130.73 APE8-dihe-in -64.81, 141.74 APE8-rot-out 194.19 APE67-dihe-in -49.12, -31.37 -104.13, -7.85 APE12-dist-out 20.4 APE11-dist-out 17.384 APE10-dist-out 19.026 APE9-dist-out 10.399 None None None XRAY 1.95 0.213 0.249 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pw2 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5ANOA 1 298 298.0 No_ligand No_ligand Inactive DFGin 10.011 17.98 BLBtrans -109.27, 158.79 58.92, 30.89 -72.89, 133.98 208.69, 112.32 71.92, -0.69 out-out out 14.806 Saltbr-out 15.12 HRD-in -77.91, -56.25 82.83, -17.44 out-out-out SNCooo out-out ActLoopNT-out 6.223 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 138.67 APE9-dihe-na -78.35, 134.03 APE8-dihe-in -78.71, 128.62 APE8-rot-out 185.32 APE67-dihe-in -58.9, -25.15 -98.01, -5.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.073 APE9-dist-out 10.707 None None None XRAY 1.7 0.204 0.255 A 298 277 21 0 0 11 [[4, 286]] 1.0 5ano CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EK3A 1 296 298.0 No_ligand No_ligand Inactive DFGin 10.621 18.284 BLBtrans -101.21, 151.46 67.49, 22.05 -57.81, 133.78 228.3, 103.37 82.48, -9.32 out-out out 15.269 Saltbr-out 17.754 HRD-in -88.61, -57.8 87.04, -20.99 out-out-out SNCooo out-out ActLoopNT-out 5.931 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.09, 127.28 APE9-dihe-na -73.13, 128.44 APE8-dihe-in -66.08, 142.79 APE8-rot-out 190.21 APE67-dihe-in -61.92, -26.37 -98.85, -4.9 APE12-dist-out 19.884 APE11-dist-out 17.226 APE10-dist-out 18.698 APE9-dist-out 10.346 None None None XRAY 1.34 0.179 0.19 A 299 288 8 0 0 0 [[4, 286]] 1.0 4ek3 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7UXKA 9 294 298.0 No_ligand No_ligand Inactive DFGin 10.989 18.062 BLBtrans -118.57, 168.29 54.94, 39.14 -99.16, 150.1 207.59, 89.89 70.2, 1.9 out-out out 17.637 Saltbr-out 14.639 HRD-in -93.8, -47.18 71.26, -2.37 out-out-out SNCooo out-out ActLoopNT-out 7.125 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.91, -71.71 APE9-dihe-na 58.26, 101.72 APE8-dihe-in -76.67, 124.55 APE8-rot-out 179.93 APE67-dihe-in -64.64, -16.98 -104.38, 3.27 APE12-dist-out 23.663 APE11-dist-out 19.081 APE10-dist-out 19.746 APE9-dist-out 11.527 None None None XRAY 2.63 0.263 0.3 A 299 246 45 0 0 0 [[4, 286]] 1.0 7uxk CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OITA 3 298 298.0 HDT:1299 Type1 Inactive DFGin 10.885 18.174 BLBtrans -105.06, 152.78 71.13, 24.78 -65.66, 139.61 237.85, 106.84 71.25, -1.81 out-out out 15.169 Saltbr-out 13.035 HRD-in -85.02, -54.68 83.17, -16.91 out-out-out SNCooo out-out ActLoopNT-out 5.81 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 136.98 APE9-dihe-na -73.6, 131.55 APE8-dihe-in -74.68, 133.59 APE8-rot-out 204.9 APE67-dihe-in -59.95, -29.35 -105.8, -2.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.623 APE9-dist-out 10.904 None None None XRAY 1.6 0.227 0.24 A 299 273 23 0 0 11 [[4, 286]] 1.0 1oit CMGC_CDK2_HUMAN CMGC 7.1e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1CKPA 1 298 298.0 PVB:299 Type1 Inactive DFGin 10.658 18.247 BLBtrans -110.41, 150.24 71.15, 24.27 -67.17, 134.25 229.06, 112.41 76.43, -10.92 out-out out 14.934 Saltbr-out 16.231 HRD-in -94.15, -50.27 76.12, -14.13 out-out-out SNCooo out-out ActLoopNT-out 5.838 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -23.52 APE8-dihe-in -85.27, 133.01 APE8-rot-in 300.53 APE67-dihe-in -51.88, -29.25 -105.56, -4.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.845 None None None XRAY 2.05 0.192 0.26 A 298 279 19 0 0 11 [[4, 286]] 1.0 1ckp CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H0VA 1 298 298.0 UN4:1299 Type1 Inactive DFGin 10.568 18.251 BLBtrans -95.92, 153.61 60.57, 23.0 -56.36, 130.3 227.88, 99.87 85.5, -9.03 out-out out 15.266 Saltbr-out 16.179 HRD-in -80.8, -62.8 86.19, -12.98 out-out-out SNCooo out-out ActLoopNT-out 5.875 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -79.64, 139.47 APE9-dihe-na -79.99, 133.5 APE8-dihe-in -76.41, 146.34 APE8-rot-out 188.74 APE67-dihe-in -61.68, -24.02 -107.76, 0.04 APE12-dist-none 999.0 APE11-dist-out 16.978 APE10-dist-out 18.767 APE9-dist-out 10.373 None None None XRAY 1.9 0.158 0.234 A 298 288 10 0 0 3 [[4, 286]] 1.0 1h0v CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H0WA 1 298 298.0 207:1299 Type1 Inactive DFGin 10.938 18.295 BLBtrans -110.88, 152.17 71.23, 19.69 -62.64, 131.76 234.97, 88.44 83.07, -13.72 out-out out 15.209 Saltbr-out 15.437 HRD-in -97.61, -53.25 83.54, -20.07 out-out-out SNCooo out-out ActLoopNT-out 5.954 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 109.93 APE8-rot-out 202.71 APE67-dihe-in -61.57, -24.53 -96.03, -0.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.214 0.287 A 298 283 15 0 0 8 [[4, 286]] 1.0 1h0w CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1JSVA 1 298 298.0 U55:400 Type1 Inactive DFGin 10.422 18.557 BLBtrans -103.0, 155.92 63.77, 22.4 -61.9, 118.34 219.35, 111.99 94.76, -3.65 out-out out 15.028 Saltbr-out 16.358 HRD-in -90.22, -56.66 84.87, -23.24 out-out-out SNCooo out-out ActLoopNT-out 6.025 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.77, 126.1 APE9-dihe-na -72.87, 131.2 APE8-dihe-in -67.47, 140.72 APE8-rot-out 185.09 APE67-dihe-in -53.31, -32.81 -106.18, -3.9 APE12-dist-out 19.993 APE11-dist-out 17.479 APE10-dist-out 18.948 APE9-dist-out 10.487 None None None XRAY 1.96 999.0 999.0 A 298 288 10 0 0 0 [[4, 286]] 1.0 1jsv CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PXIA 1 298 298.0 CK1:500 Type1 Inactive DFGin 10.897 18.399 BLBtrans -102.28, 152.73 60.72, 30.42 -65.08, 133.41 220.9, 107.51 83.57, -9.56 out-out out 15.118 Saltbr-out 17.565 HRD-in -95.21, -55.86 78.53, -11.29 out-out-out SNCooo out-out ActLoopNT-out 5.676 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.33, 123.92 APE9-dihe-na -70.81, 127.45 APE8-dihe-in -62.48, 142.43 APE8-rot-out 188.84 APE67-dihe-in -51.84, -32.28 -107.42, -0.11 APE12-dist-out 20.689 APE11-dist-out 17.741 APE10-dist-out 19.115 APE9-dist-out 10.433 None None None XRAY 1.95 0.203 0.251 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pxi CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PXJA 1 298 298.0 CK2:500 Type1 Inactive DFGin 10.238 18.323 BLBtrans -108.12, 154.72 59.41, 34.48 -70.19, 130.25 212.07, 108.72 84.22, -11.22 out-out out 15.002 Saltbr-out 19.485 HRD-in -87.43, -51.91 79.87, -15.33 out-out-out SNCooo out-out ActLoopNT-out 5.82 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.98, 124.23 APE9-dihe-na -73.35, 137.11 APE8-dihe-in -70.59, 144.9 APE8-rot-out 191.49 APE67-dihe-in -50.02, -34.42 -112.23, -2.53 APE12-dist-out 20.654 APE11-dist-out 17.589 APE10-dist-out 19.237 APE9-dist-out 10.746 None None None XRAY 2.3 0.21 0.271 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pxj CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PXKA 1 298 298.0 CK3:500 Type1 Inactive DFGin 10.633 18.358 BLBtrans -120.53, 149.99 70.8, 20.93 -68.6, 140.34 208.5, 128.57 68.2, 6.43 out-out out 15.385 Saltbr-out 17.925 HRD-in -95.64, -28.38 63.77, -32.98 out-out-out SNCooo out-out ActLoopNT-out 5.745 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -141.61, 141.31 APE9-dihe-na -65.99, -156.71 APE8-dihe-in -132.29, 131.16 APE8-rot-in 292.3 APE67-dihe-in -43.35, -34.23 -96.72, -15.61 APE12-dist-out 20.668 APE11-dist-out 18.813 APE10-dist-out 18.652 APE9-dist-out 10.683 None None None XRAY 2.8 0.21 0.266 A 298 290 8 0 0 0 [[4, 286]] 1.0 1pxk CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PXLA 1 298 298.0 CK4:500 Type1 Inactive DFGin 10.319 17.894 BLBtrans -106.75, 159.26 54.48, 36.35 -71.0, 141.72 217.81, 113.59 61.53, 0.4 out-out out 14.812 Saltbr-out 16.666 HRD-in -90.63, -45.54 75.31, -14.31 out-out-out SNCooo out-out ActLoopNT-out 5.805 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.02, 137.84 APE9-dihe-na -76.37, 157.28 APE8-dihe-in -111.34, 122.45 APE8-rot-in 287.26 APE67-dihe-in -49.25, -32.38 -102.21, 0.82 APE12-dist-out 20.361 APE11-dist-out 17.316 APE10-dist-out 19.26 APE9-dist-out 11.009 None None None XRAY 2.5 0.21 0.249 A 298 290 8 0 0 0 [[4, 286]] 1.0 1pxl CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PXMA 1 298 298.0 CK5:500 Type1 Inactive DFGin 10.494 17.955 BLBtrans -127.08, 145.53 72.49, 39.5 -81.2, 137.28 222.14, 106.81 81.68, -25.06 out-out out 14.709 Saltbr-out 12.258 HRD-in -90.04, -53.5 75.75, -9.0 out-out-out SNCooo out-out ActLoopNT-out 5.586 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -114.35, 122.77 APE9-dihe-na -110.17, 127.38 APE8-dihe-in -85.46, 147.67 APE8-rot-out 49.58 APE67-dihe-in -43.55, -35.48 -95.51, -8.06 APE12-dist-out 20.552 APE11-dist-out 19.349 APE10-dist-out 19.632 APE9-dist-out 10.695 None None None XRAY 2.53 0.225 0.28 A 298 290 8 0 0 0 [[4, 286]] 1.0 1pxm CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PXNA 1 298 298.0 CK6:500 Type1 Inactive DFGin 10.103 18.396 BLBtrans -124.71, 142.11 73.33, 24.67 -66.11, 112.31 205.53, 110.77 91.17, -4.77 out-out out 15.55 Saltbr-out 16.119 HRD-in -80.71, -53.56 86.8, -27.65 out-out-out SNCooo out-out ActLoopNT-out 6.006 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -143.37, 111.83 APE9-dihe-na -74.2, -142.96 APE8-dihe-in -161.01, 119.39 APE8-rot-out 178.65 APE67-dihe-in -57.39, -35.33 -89.99, 2.7 APE12-dist-out 19.884 APE11-dist-out 18.531 APE10-dist-out 19.559 APE9-dist-out 11.13 None None None XRAY 2.5 0.24 0.277 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pxn CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PXPA 1 298 298.0 CK8:500 Type1 Inactive DFGin 10.603 17.742 BLBtrans -113.05, 154.9 70.73, 32.65 -74.6, 130.58 226.9, 118.91 82.84, -5.59 out-out out 15.062 Saltbr-out 15.822 HRD-in -86.63, -50.87 79.85, -16.9 out-out-out SNCooo out-out ActLoopNT-out 5.794 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.97, 139.84 APE9-dihe-na -79.23, 137.29 APE8-dihe-in -88.93, 135.37 APE8-rot-out 187.31 APE67-dihe-in -53.16, -23.41 -112.15, 2.68 APE12-dist-out 21.098 APE11-dist-out 18.491 APE10-dist-out 19.363 APE9-dist-out 10.965 None None None XRAY 2.3 0.23 0.273 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pxp CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1VYZA 1 298 298.0 N5B:300 Type1 Inactive DFGin 10.688 18.214 BLBtrans -109.49, 154.91 64.84, 32.78 -74.07, 129.55 227.59, 110.86 80.0, -3.59 out-out out 15.296 Saltbr-out 15.452 HRD-in -89.74, -53.71 76.62, -24.24 out-out-out SNCooo out-out ActLoopNT-out 5.759 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -89.53, 120.92 APE9-dihe-na -77.34, 137.58 APE8-dihe-in -73.72, 136.79 APE8-rot-out 193.67 APE67-dihe-in -53.83, -31.46 -107.75, -0.05 APE12-dist-none 999.0 APE11-dist-out 17.214 APE10-dist-out 19.359 APE9-dist-out 10.717 None None None XRAY 2.21 0.238 0.28 A 298 279 19 0 0 8 [[4, 286]] 1.0 1vyz CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1W0XC 1 298 298.0 OLO:1299 Type1 Inactive DFGin 10.635 18.434 BLBtrans -104.48, 149.93 70.96, 24.05 -67.85, 122.98 217.55, 109.56 85.65, -3.99 out-out out 14.815 Saltbr-out 15.461 HRD-in -90.26, -53.28 75.19, -6.69 out-out-out SNCooo out-out ActLoopNT-out 5.645 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 116.93 APE8-dihe-in -66.78, 124.27 APE8-rot-out 58.47 APE67-dihe-in -42.9, -37.07 -89.95, -9.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.546 None None None XRAY 2.2 0.19 0.27 C 298 280 18 0 0 11 [[4, 286]] 1.0 1w0x CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1WCCA 1 298 298.0 CIG:1299 Type1 Inactive DFGin 10.586 18.321 BLBtrans -101.25, 153.71 65.29, 26.63 -65.21, 135.37 225.73, 104.14 82.03, -16.28 out-out out 14.979 Saltbr-out 16.921 HRD-in -84.12, -58.51 86.27, -25.3 out-out-out SNCooo out-out ActLoopNT-out 5.935 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 136.37 APE8-dihe-in -68.44, 144.08 APE8-rot-out 189.92 APE67-dihe-in -58.92, -27.89 -101.32, -7.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.634 None None None XRAY 2.2 0.181 0.252 A 298 283 15 0 0 11 [[4, 286]] 1.0 1wcc CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1Y8YA 1 298 298.0 CT7:401 Type1 Inactive DFGin 10.802 18.336 BLBtrans -93.05, 152.29 68.15, 20.21 -59.43, 132.26 231.44, 99.39 87.04, -10.02 out-out out 15.019 Saltbr-out 17.27 HRD-in -92.34, -57.55 83.14, -15.31 out-out-out SNCooo out-out ActLoopNT-out 5.87 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.89, 126.27 APE9-dihe-na -73.81, 132.79 APE8-dihe-in -65.58, 139.9 APE8-rot-in 357.44 APE67-dihe-in -55.44, -30.03 -94.0, -8.51 APE12-dist-out 20.141 APE11-dist-out 17.17 APE10-dist-out 18.868 APE9-dist-out 10.134 None None None XRAY 1.996 0.194 0.272 A 298 292 6 0 0 0 [[4, 286]] 1.0 1y8y CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1Y91A 1 298 298.0 CT9:401 Type1 Inactive DFGin 8.864 16.911 BLBtrans -125.44, 148.26 61.53, 68.01 -127.38, 99.79 187.98, 151.56 96.61, 4.77 out-out out 14.402 Saltbr-out 14.821 HRD-in -75.48, -49.24 84.65, -25.96 out-out-out SNCooo out-out ActLoopNT-out 6.152 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.01, 137.71 APE9-dihe-na -78.47, 147.44 APE8-dihe-in -81.3, 148.72 APE8-rot-out 57.59 APE67-dihe-in -60.75, -24.22 -105.63, -8.34 APE12-dist-out 18.361 APE11-dist-out 17.258 APE10-dist-out 18.486 APE9-dist-out 10.58 None None None XRAY 2.15 0.201 0.295 A 298 286 12 0 0 5 [[4, 286]] 1.0 1y91 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1YKRA 1 298 298.0 628:299 Type1 Inactive DFGin 10.222 18.192 BLBtrans -123.66, 150.21 67.9, 31.8 -75.65, 128.85 216.59, 119.16 83.51, -17.56 out-out out 14.614 Saltbr-out 15.675 HRD-in -77.09, -58.51 83.53, -24.18 out-out-out SNCooo out-out ActLoopNT-out 5.858 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.38, 138.29 APE9-dihe-na -82.48, 131.51 APE8-dihe-in -66.73, 137.13 APE8-rot-out 185.5 APE67-dihe-in -46.84, -30.37 -107.85, -9.08 APE12-dist-out 20.037 APE11-dist-out 17.297 APE10-dist-out 18.959 APE9-dist-out 10.443 None None None XRAY 1.8 0.275 0.271 A 298 298 0 0 0 0 [[4, 286]] 1.0 1ykr CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2A0CX 1 298 298.0 CK9:500 Type1 Inactive DFGin 10.368 17.87 BLBtrans -121.46, 148.74 74.57, 23.53 -63.68, 126.4 226.4, 113.11 76.73, -2.49 out-out out 15.046 Saltbr-out 15.708 HRD-in -81.58, -52.61 83.44, -22.41 out-out-out SNCooo out-out ActLoopNT-out 6.079 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.44, 129.98 APE9-dihe-na -82.75, 128.43 APE8-dihe-in -81.81, 146.34 APE8-rot-out 113.9 APE67-dihe-in -60.56, -25.38 -104.96, -6.1 APE12-dist-out 19.304 APE11-dist-out 17.905 APE10-dist-out 19.029 APE9-dist-out 10.501 None None None XRAY 1.95 0.194 0.244 X 298 294 4 0 0 0 [[4, 286]] 1.0 2a0c CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2A4LA 1 298 298.0 RRC:300 Type1 Inactive DFGin 10.578 18.411 BLBtrans -113.59, 145.45 72.4, 28.76 -70.81, 127.39 225.24, 108.51 92.04, -16.08 out-out out 14.805 Saltbr-out 16.652 HRD-in -77.2, -70.83 76.49, 13.56 out-out-out SNCooo out-out ActLoopNT-out 5.706 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.63, 118.77 APE9-dihe-na -67.51, 125.09 APE8-dihe-in -56.92, 143.85 APE8-rot-out 190.58 APE67-dihe-in -61.81, -25.37 -102.66, -1.04 APE12-dist-out 20.053 APE11-dist-out 17.36 APE10-dist-out 19.19 APE9-dist-out 10.465 None None None XRAY 2.4 0.173 0.27 A 298 286 12 0 0 0 [[4, 286]] 1.0 2a4l CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2B53A 1 298 298.0 D23:299 Type1 Inactive DFGin 10.882 18.163 BLBtrans -105.07, 159.12 64.05, 24.72 -63.04, 128.95 225.92, 111.71 75.84, -23.79 out-out out 15.253 Saltbr-out 16.48 HRD-in -79.41, -54.58 56.47, 10.12 out-out-out SNCooo out-out ActLoopNT-out 5.902 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.9, 132.3 APE9-dihe-na -81.38, 149.71 APE8-dihe-in -74.63, 144.34 APE8-rot-out 188.99 APE67-dihe-in -65.39, -20.02 -90.36, -6.23 APE12-dist-out 19.861 APE11-dist-out 17.069 APE10-dist-out 19.106 APE9-dist-out 10.715 None None None XRAY 2.0 0.223 0.273 A 298 294 4 0 0 0 [[4, 286]] 1.0 2b53 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2B54A 1 298 298.0 D05:300 Type1 Inactive DFGin 10.425 18.175 BLBtrans -108.08, 148.55 65.13, 25.93 -58.02, 130.21 219.52, 123.27 68.09, -12.73 out-out out 15.182 Saltbr-out 18.18 HRD-in -77.1, -66.85 92.16, -28.1 out-out-out SNCooo out-out ActLoopNT-out 6.303 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -86.0, 154.69 APE9-dihe-na -36.24, -70.21 APE8-dihe-out 117.83, 111.97 APE8-rot-in 242.96 APE67-dihe-in -58.21, -28.73 -91.0, 1.3 APE12-dist-out 19.844 APE11-dist-out 20.236 APE10-dist-out 18.851 APE9-dist-out 10.408 None None None XRAY 1.85 0.158 0.263 A 298 298 0 0 0 0 [[4, 286]] 1.0 2b54 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2BTRA 1 298 298.0 U73:300 Type1 Inactive DFGin 9.764 17.726 BLBtrans -121.82, 148.54 71.66, 41.31 -85.73, 127.52 209.72, 126.21 68.87, 10.3 out-out out 14.551 Saltbr-out 14.451 HRD-in -75.68, -54.61 83.11, -22.31 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -82.81, 129.34 APE9-dihe-na -76.72, 133.59 APE8-dihe-in -79.67, 136.44 APE8-rot-out 182.55 APE67-dihe-in -67.18, -21.33 -102.97, -4.89 APE12-dist-none 999.0 APE11-dist-out 17.405 APE10-dist-out 19.155 APE9-dist-out 10.688 None None None XRAY 1.85 0.226 0.272 A 298 275 23 0 0 12 [[4, 286]] 1.0 2btr CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C68A 1 296 298.0 CT6:1297 Type1 Inactive DFGin 10.76 18.325 BLBtrans -94.64, 152.26 66.7, 20.98 -56.36, 137.22 230.82, 103.49 83.52, -14.96 out-out out 14.985 Saltbr-out 17.123 HRD-in -85.6, -58.37 80.29, -19.26 out-out-out SNCooo out-out ActLoopNT-out 5.755 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -73.85, 124.5 APE9-dihe-na -68.76, 129.84 APE8-dihe-in -65.16, 145.74 APE8-rot-in 347.97 APE67-dihe-in -57.11, -30.73 -103.28, -2.46 APE12-dist-out 20.352 APE11-dist-out 17.744 APE10-dist-out 19.065 APE9-dist-out 10.259 None None None XRAY 1.95 0.185 0.249 A 298 290 6 0 0 0 [[4, 286]] 1.0 2c68 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C69A 1 298 298.0 CT8:1299 Type1 Inactive DFGin 10.415 18.32 BLBtrans -90.57, 151.57 62.61, 28.01 -62.3, 129.63 222.26, 96.56 87.81, -11.92 out-out out 15.281 Saltbr-out 16.105 HRD-in -83.84, -61.73 85.0, -18.92 out-out-out SNCooo out-out ActLoopNT-out 5.88 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -63.82, 130.06 APE9-dihe-na -77.49, 126.35 APE8-dihe-in -72.2, 149.08 APE8-rot-out 64.27 APE67-dihe-in -56.94, -25.1 -106.47, -1.27 APE12-dist-out 20.392 APE11-dist-out 17.64 APE10-dist-out 19.017 APE9-dist-out 10.524 None None None XRAY 2.1 0.21 0.28 A 298 292 6 0 0 0 [[4, 286]] 1.0 2c69 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C6IA 1 298 298.0 DT1:1299 Type1 Inactive DFGin 10.462 18.307 BLBtrans -99.46, 150.69 63.73, 25.39 -61.45, 132.26 223.16, 103.52 80.67, -7.99 out-out out 14.883 Saltbr-out 16.814 HRD-in -84.75, -59.11 84.73, -24.8 out-out-out SNCooo out-out ActLoopNT-out 5.839 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -80.81, 129.22 APE9-dihe-na -72.98, 142.58 APE8-dihe-in -69.39, 141.06 APE8-rot-out 0.75 APE67-dihe-in -60.33, -26.73 -100.82, -3.43 APE12-dist-out 20.812 APE11-dist-out 17.496 APE10-dist-out 19.372 APE9-dist-out 10.651 None None None XRAY 1.8 0.208 0.275 A 298 292 6 0 0 0 [[4, 286]] 1.0 2c6i CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C6KA 1 298 298.0 DT2:1299 Type1 Inactive DFGin 10.434 18.369 BLBtrans -95.81, 155.41 61.87, 21.94 -57.39, 133.32 223.97, 97.37 83.11, -10.49 out-out out 15.056 Saltbr-out 17.417 HRD-in -83.95, -62.86 83.19, -14.52 out-out-out SNCooo out-out ActLoopNT-out 5.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -77.24, 125.28 APE9-dihe-na -72.71, 134.37 APE8-dihe-in -64.9, 140.95 APE8-rot-in 358.04 APE67-dihe-in -57.82, -30.08 -97.62, -4.03 APE12-dist-out 20.649 APE11-dist-out 17.566 APE10-dist-out 19.161 APE9-dist-out 10.525 None None None XRAY 1.9 0.189 0.254 A 298 292 6 0 0 0 [[4, 286]] 1.0 2c6k CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C6LA 1 298 298.0 DT4:1299 Type1 Inactive DFGin 10.158 18.391 BLBtrans -100.45, 154.57 54.48, 33.32 -59.27, 133.99 220.86, 104.35 78.25, -11.95 out-out out 15.211 Saltbr-out 16.864 HRD-in -90.51, -53.62 83.67, -17.08 out-out-out SNCooo out-out ActLoopNT-out 6.067 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.7, 129.61 APE9-dihe-na -79.31, 143.05 APE8-dihe-in -77.96, 139.63 APE8-rot-out 62.29 APE67-dihe-in -50.61, -32.1 -97.33, -6.25 APE12-dist-out 20.31 APE11-dist-out 17.283 APE10-dist-out 19.211 APE9-dist-out 10.707 None None None XRAY 2.3 0.185 0.281 A 298 291 7 0 0 0 [[4, 286]] 1.0 2c6l CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C6MA 1 296 298.0 DT5:1297 Type1 Inactive DFGin 10.737 18.406 BLBtrans -99.56, 151.64 64.8, 23.03 -61.35, 135.89 223.66, 106.68 83.78, -17.16 out-out out 15.099 Saltbr-out 17.495 HRD-in -82.46, -59.33 77.2, -19.23 out-out-out SNCooo out-out ActLoopNT-out 5.632 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.76, 130.16 APE9-dihe-na -74.21, 136.72 APE8-dihe-in -74.65, 138.26 APE8-rot-in 303.83 APE67-dihe-in -54.03, -32.67 -99.18, -6.49 APE12-dist-out 20.875 APE11-dist-out 17.667 APE10-dist-out 19.357 APE9-dist-out 10.485 None None None XRAY 1.9 0.201 0.27 A 298 290 6 0 0 0 [[4, 286]] 1.0 2c6m CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2CLXA 1 298 298.0 F18:1299 Type1 Inactive DFGin 10.588 18.233 BLBtrans -102.39, 162.05 57.48, 23.46 -58.08, 132.34 226.08, 105.77 84.3, -12.61 out-out out 15.003 Saltbr-out 16.115 HRD-in -80.79, -59.4 83.97, -11.26 out-out-out SNCooo out-out ActLoopNT-out 5.89 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -83.03, 139.33 APE9-dihe-na -72.69, 129.82 APE8-dihe-in -70.52, 142.86 APE8-rot-out 190.27 APE67-dihe-in -60.8, -23.74 -103.33, -5.09 APE12-dist-out 19.792 APE11-dist-out 17.554 APE10-dist-out 18.562 APE9-dist-out 10.434 None None None XRAY 1.8 0.18 0.231 A 298 293 5 0 0 0 [[4, 286]] 1.0 2clx CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2DUVA 1 298 298.0 371:501 Type1 Inactive DFGin 10.031 17.781 BLBtrans -116.25, 145.76 75.25, 33.36 -79.03, 116.4 219.7, 127.13 90.83, -5.88 out-out out 14.482 Saltbr-out 15.191 HRD-in -86.09, -48.51 82.04, -25.16 out-out-out SNCooo out-out ActLoopNT-out 5.987 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -15.38 APE8-dihe-in -61.65, 144.55 APE8-rot-in 320.23 APE67-dihe-in -55.57, -25.12 -119.67, -0.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.52 None None None XRAY 2.2 0.264 0.31 A 298 272 26 0 0 13 [[4, 286]] 1.0 2duv CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2EXMA 1 298 298.0 ZIP:400 Type1 Inactive DFGin 10.788 18.565 BLBtrans -100.65, 151.13 60.17, 32.11 -66.39, 135.89 219.64, 103.71 75.85, -5.33 out-out out 15.262 Saltbr-out 18.416 HRD-in -94.2, -54.29 65.89, 4.65 out-out-out SNCooo out-out ActLoopNT-out 5.715 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -90.77, 117.53 APE9-dihe-na -63.29, 130.07 APE8-dihe-in -65.88, 138.18 APE8-rot-out 189.6 APE67-dihe-in -56.66, -22.93 -106.35, -1.75 APE12-dist-out 21.055 APE11-dist-out 17.67 APE10-dist-out 19.516 APE9-dist-out 10.681 None None None XRAY 1.8 0.2 0.27 A 298 298 0 0 0 0 [[4, 286]] 1.0 2exm CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R64A 1 298 298.0 740:500 Type1 Inactive DFGin 10.346 18.098 BLBtrans -120.32, 149.34 72.4, 29.07 -75.94, 125.74 220.77, 115.04 86.21, -16.87 out-out out 14.75 Saltbr-out 15.678 HRD-in -88.9, -49.6 77.12, -14.1 out-out-out SNCooo out-out ActLoopNT-out 5.984 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -21.46 APE8-dihe-in -80.9, 138.5 APE8-rot-in 305.01 APE67-dihe-in -55.8, -26.36 -111.59, -0.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.919 None None None XRAY 2.3 0.221 0.257 A 298 279 19 0 0 11 [[4, 286]] 1.0 2r64 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UZNA 1 298 298.0 C96:1299 Type1 Inactive DFGin 10.249 18.225 BLBtrans -111.08, 157.15 69.94, 16.94 -64.75, 137.42 221.99, 89.97 72.31, -22.14 out-out out 14.958 Saltbr-out 15.701 HRD-in -74.51, -50.05 78.55, -16.25 out-out-out SNCooo out-out ActLoopNT-out 5.729 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 121.18 APE9-dihe-na -92.03, 119.74 APE8-dihe-in -70.41, 154.56 APE8-rot-out 59.26 APE67-dihe-in -58.36, -30.79 -112.91, 7.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.465 APE9-dist-out 10.792 None None None XRAY 2.3 0.206 0.297 A 298 279 19 0 0 10 [[4, 286]] 1.0 2uzn CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2V0DA 1 298 298.0 C53:1299 Type1 Inactive DFGin 10.516 18.357 BLBtrans -90.76, 153.42 63.43, 25.77 -65.85, 136.11 224.67, 105.43 80.41, -11.53 out-out out 15.218 Saltbr-out 17.829 HRD-in -88.48, -62.53 84.08, -9.99 out-out-out SNCooo out-out ActLoopNT-out 6.036 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.84, 132.62 APE9-dihe-na -78.23, 133.36 APE8-dihe-in -76.41, 151.22 APE8-rot-out 63.9 APE67-dihe-in -58.52, -31.19 -107.7, -0.79 APE12-dist-out 20.61 APE11-dist-out 17.499 APE10-dist-out 19.167 APE9-dist-out 10.549 None None None XRAY 2.2 0.197 0.286 A 298 292 6 0 0 0 [[4, 286]] 1.0 2v0d CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTAA 1 298 298.0 LZ1:1301 Type1 Inactive DFGin 10.244 18.138 BLBtrans -104.45, 152.93 66.32, 26.32 -69.72, 124.46 220.25, 101.96 88.32, -5.61 out-out out 14.874 Saltbr-out 14.93 HRD-in -83.93, -53.12 78.45, -19.94 out-out-out SNCooo out-out ActLoopNT-out 6.148 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.47 APE8-dihe-in -76.65, 133.94 APE8-rot-out 186.51 APE67-dihe-in -62.46, -25.45 -101.56, -6.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.849 None None None XRAY 2.0 0.236 0.28 A 298 278 20 0 0 11 [[4, 286]] 1.0 2vta CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTHA 1 298 298.0 LZ2:1300 Type1 Inactive DFGin 10.287 18.273 BLBtrans -106.71, 150.66 70.62, 25.54 -66.91, 134.3 220.5, 107.59 73.3, -7.87 out-out out 14.696 Saltbr-out 15.634 HRD-in -81.69, -51.97 78.25, -22.9 out-out-out SNCooo out-out ActLoopNT-out 5.972 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -53.91 APE8-dihe-in -67.54, 130.71 APE8-rot-out 187.68 APE67-dihe-in -55.82, -28.32 -96.45, -10.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.681 None None None XRAY 1.9 0.2 0.241 A 298 278 20 0 0 11 [[4, 286]] 1.0 2vth CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTIA 1 298 298.0 LZ3:1299 Type1 Inactive DFGin 10.725 18.188 BLBtrans -110.35, 147.76 74.49, 17.02 -59.73, 132.8 228.42, 109.53 79.35, -10.32 out-out out 14.867 Saltbr-out 17.15 HRD-in -85.9, -54.67 80.77, -23.6 out-out-out SNCooo out-out ActLoopNT-out 5.892 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -11.49 APE9-dihe-na -59.31, 112.3 APE8-dihe-in -77.31, 134.88 APE8-rot-out 193.8 APE67-dihe-in -60.86, -27.25 -104.56, -7.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.393 APE9-dist-out 10.806 None None None XRAY 2.0 0.168 0.199 A 298 280 18 0 0 10 [[4, 286]] 1.0 2vti CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTJA 1 298 298.0 LZ4:1300 Type1 Inactive DFGin 10.942 17.812 BLBtrans -112.48, 145.27 93.11, 19.59 -86.02, 134.26 217.07, 102.87 75.44, 13.46 out-out out 14.92 Saltbr-out 12.128 HRD-in -80.23, -55.69 82.5, -23.97 out-out-out SNCooo out-out ActLoopNT-out 6.312 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -18.44 APE8-dihe-in -66.07, 130.3 APE8-rot-in 307.21 APE67-dihe-in -61.99, -27.74 -96.84, -6.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.942 None None None XRAY 2.2 0.19 0.262 A 298 276 22 0 0 13 [[4, 286]] 1.0 2vtj CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTLA 1 298 298.0 LZ5:1299 Type1 Inactive DFGin 10.572 18.326 BLBtrans -95.19, 158.58 63.54, 21.35 -61.28, 134.23 224.65, 107.42 78.25, -9.64 out-out out 14.986 Saltbr-out 17.624 HRD-in -86.49, -57.46 86.32, -13.65 out-out-out SNCooo out-out ActLoopNT-out 5.937 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.76, 124.79 APE9-dihe-na -61.9, 124.78 APE8-dihe-in -64.39, 143.02 APE8-rot-out 186.35 APE67-dihe-in -54.11, -28.95 -100.63, -8.09 APE12-dist-out 20.034 APE11-dist-out 17.595 APE10-dist-out 18.837 APE9-dist-out 10.293 None None None XRAY 2.0 0.182 0.235 A 298 290 8 0 0 0 [[4, 286]] 1.0 2vtl CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTMA 1 298 298.0 LZM:1299 Type1 Inactive DFGin 10.448 18.267 BLBtrans -101.32, 161.31 52.39, 30.09 -66.37, 132.5 224.52, 107.45 84.41, -8.96 out-out out 14.54 Saltbr-out 17.417 HRD-in -82.9, -55.22 81.65, -22.34 out-out-out SNCooo out-out ActLoopNT-out 5.977 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.63, 118.4 APE9-dihe-na -55.56, 132.06 APE8-dihe-in -68.18, 138.39 APE8-rot-out 194.59 APE67-dihe-in -52.68, -31.15 -98.48, -10.51 APE12-dist-out 19.912 APE11-dist-out 17.061 APE10-dist-out 18.946 APE9-dist-out 10.572 None None None XRAY 2.25 0.231 0.286 A 298 290 8 0 0 0 [[4, 286]] 1.0 2vtm CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTOA 1 298 298.0 LZ8:1299 Type1 Inactive DFGin 10.039 17.924 BLBtrans -108.91, 161.79 70.67, 17.02 -63.88, 134.77 224.21, 116.93 82.51, -17.59 out-out out 14.812 Saltbr-out 14.491 HRD-in -84.16, -55.57 82.44, -8.45 out-out-out SNCooo out-out ActLoopNT-out 6.214 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.4, 128.62 APE9-dihe-na -65.57, 127.71 APE8-dihe-in -64.51, 143.05 APE8-rot-out 180.96 APE67-dihe-in -63.75, -23.85 -104.79, -0.81 APE12-dist-out 16.221 APE11-dist-out 17.84 APE10-dist-out 18.719 APE9-dist-out 10.489 None None None XRAY 2.19 0.178 0.241 A 298 283 15 0 0 8 [[4, 286]] 1.0 2vto CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTPA 1 298 298.0 LZ9:1299 Type1 Inactive DFGin 10.132 18.029 BLBtrans -104.49, 153.05 65.1, 24.04 -59.74, 134.35 220.34, 118.07 73.64, -15.52 out-out out 14.445 Saltbr-out 15.991 HRD-in -77.26, -54.17 79.25, -11.7 out-out-out SNCooo out-out ActLoopNT-out 5.923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -72.1, 128.96 APE9-dihe-na -78.85, 134.77 APE8-dihe-in -71.14, 143.67 APE8-rot-out 185.57 APE67-dihe-in -56.09, -28.32 -107.11, -2.38 APE12-dist-none 999.0 APE11-dist-out 17.345 APE10-dist-out 19.173 APE9-dist-out 10.604 None None None XRAY 2.15 0.189 0.247 A 298 281 17 0 0 9 [[4, 286]] 1.0 2vtp CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTRA 1 298 298.0 LZB:1299 Type1 Inactive DFGin 10.582 18.154 BLBtrans -103.84, 155.96 69.48, 14.66 -61.19, 110.05 222.38, 99.71 106.33, -13.63 out-out out 14.983 Saltbr-out 15.404 HRD-in -82.13, -59.82 91.3, -22.94 out-out-out SNCooo out-out ActLoopNT-out 5.729 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -60.45, 137.14 APE9-dihe-na -72.22, 127.52 APE8-dihe-in -65.44, 136.61 APE8-rot-out 185.79 APE67-dihe-in -56.56, -25.41 -95.85, -7.23 APE12-dist-out 19.94 APE11-dist-out 17.332 APE10-dist-out 18.839 APE9-dist-out 10.193 None None None XRAY 1.89 0.209 0.261 A 298 290 8 0 0 0 [[4, 286]] 1.0 2vtr CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2VTSA 1 298 298.0 LZC:1299 Type1 Inactive DFGin 10.163 18.23 BLBtrans -119.12, 159.33 60.82, 24.43 -70.34, 115.84 219.94, 123.35 104.26, -22.17 out-out out 14.805 Saltbr-out 17.557 HRD-in -79.85, -53.15 81.89, -18.41 out-out-out SNCooo out-out ActLoopNT-out 5.98 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.34, 127.3 APE9-dihe-na -68.41, 127.95 APE8-dihe-in -65.04, 136.98 APE8-rot-out 190.16 APE67-dihe-in -60.72, -22.35 -99.36, -3.08 APE12-dist-out 17.838 APE11-dist-out 17.552 APE10-dist-out 19.128 APE9-dist-out 10.603 None None None XRAY 1.9 0.212 0.261 A 298 282 16 0 0 8 [[4, 286]] 1.0 2vts CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2W1HA 1 298 298.0 L0F:1299 Type1 Inactive DFGin 10.307 17.775 BLBtrans -130.06, 151.5 79.56, 18.75 -69.93, 141.61 226.73, 121.67 69.65, -12.05 out-out out 14.489 Saltbr-out 16.038 HRD-in -88.39, -56.31 79.17, -16.22 out-out-out SNCooo out-out ActLoopNT-out 5.457 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.46 APE8-dihe-in -76.22, 142.93 APE8-rot-out 186.46 APE67-dihe-in -49.35, -36.85 -110.85, -4.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.805 None None None XRAY 2.15 0.263 0.308 A 298 283 15 0 0 11 [[4, 286]] 1.0 2w1h CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2XMYA 1 298 298.0 CDK:500 Type1 Inactive DFGin 9.506 17.225 BLBtrans -117.75, 160.49 71.73, 41.55 -108.26, 125.38 192.76, 129.27 69.97, 4.64 out-out out 14.773 Saltbr-out 16.98 HRD-in -84.89, -51.15 78.64, -20.0 out-out-out SNCooo out-out ActLoopNT-out 5.777 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -69.87, 141.67 APE9-dihe-na -77.68, 137.44 APE8-dihe-in -77.42, 137.41 APE8-rot-in 308.69 APE67-dihe-in -65.3, -23.26 -104.09, 2.97 APE12-dist-out 20.719 APE11-dist-out 17.904 APE10-dist-out 19.064 APE9-dist-out 10.662 None None None XRAY 1.9 0.192 0.271 A 298 295 3 0 0 0 [[4, 286]] 1.0 2xmy CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3FZ1A 1 298 298.0 B98:299 Type1 Inactive DFGin 10.083 18.037 BLBtrans -118.6, 152.18 64.15, 33.3 -73.55, 125.13 214.73, 110.59 83.76, -5.83 out-out out 15.114 Saltbr-out 13.891 HRD-in -78.55, -50.44 81.59, -23.72 out-out-out SNCooo out-out ActLoopNT-out 6.061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.64, 140.89 APE9-dihe-na -76.81, 120.94 APE8-dihe-in -67.51, 133.31 APE8-rot-out 180.19 APE67-dihe-in -56.59, -25.97 -101.64, -4.23 APE12-dist-out 20.126 APE11-dist-out 17.003 APE10-dist-out 18.909 APE9-dist-out 10.527 None None None XRAY 1.9 0.212 0.259 A 298 284 14 0 0 7 [[4, 286]] 1.0 3fz1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3LE6A 1 294 298.0 2BZ:299 Type1 Inactive DFGin 10.638 18.449 BLBtrans -102.49, 158.82 69.29, 14.76 -61.56, 127.21 218.65, 111.0 90.68, -11.47 out-out out 15.158 Saltbr-out 16.245 HRD-in -81.11, -59.0 87.78, -20.02 out-out-out SNCooo out-out ActLoopNT-out 5.71 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.94, 126.63 APE9-dihe-na -72.89, 125.92 APE8-dihe-in -65.07, 145.22 APE8-rot-out 186.34 APE67-dihe-in -59.6, -24.81 -103.73, -4.84 APE12-dist-out 19.668 APE11-dist-out 17.428 APE10-dist-out 18.924 APE9-dist-out 10.202 None None None XRAY 2.0 0.196 0.248 A 298 283 11 0 0 0 [[4, 286]] 1.0 3le6 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3LFNA 1 298 298.0 A27:299 Type1 Inactive DFGin 10.089 17.665 BLBtrans -125.43, 160.37 77.0, 10.74 -63.35, 141.89 235.1, 113.67 61.92, -8.5 out-out out 14.952 Saltbr-out 16.384 HRD-in -81.9, -51.28 80.02, -30.16 out-out-out SNCooo out-out ActLoopNT-out 6.328 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.56, 125.69 APE9-dihe-na -74.55, 125.84 APE8-dihe-in -67.73, 132.89 APE8-rot-out 199.9 APE67-dihe-in -49.96, -34.34 -104.26, -9.08 APE12-dist-out 18.604 APE11-dist-out 17.226 APE10-dist-out 19.199 APE9-dist-out 10.704 None None None XRAY 2.28 0.19 0.268 A 298 285 13 0 0 9 [[4, 286]] 1.0 3lfn CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3LFQA 1 298 298.0 A28:299 Type1 Inactive DFGin 10.75 18.712 BLBtrans -102.92, 158.26 67.07, 16.29 -65.32, 123.21 221.43, 110.96 95.12, -12.64 out-out out 15.439 Saltbr-out 16.61 HRD-in -84.03, -56.82 81.21, -14.37 out-out-out SNCooo out-out ActLoopNT-out 5.611 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.35, 125.34 APE9-dihe-na -72.15, 126.09 APE8-dihe-in -56.03, 136.4 APE8-rot-out 193.63 APE67-dihe-in -52.01, -33.31 -102.71, -9.78 APE12-dist-out 19.658 APE11-dist-out 17.247 APE10-dist-out 18.861 APE9-dist-out 10.269 None None None XRAY 2.03 0.187 0.241 A 298 289 9 0 0 0 [[4, 286]] 1.0 3lfq CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3LFSA 1 298 298.0 A07:299 Type1 Inactive DFGin 10.723 18.749 BLBtrans -100.95, 160.64 60.15, 21.08 -66.79, 119.13 218.62, 110.24 99.72, -14.09 out-out out 15.297 Saltbr-out 15.328 HRD-in -80.77, -57.76 84.69, -12.96 out-out-out SNCooo out-out ActLoopNT-out 5.742 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.56, 123.33 APE9-dihe-na -71.47, 122.87 APE8-dihe-in -54.7, 135.66 APE8-rot-out 202.71 APE67-dihe-in -44.75, -36.68 -101.07, -17.2 APE12-dist-out 19.923 APE11-dist-out 17.537 APE10-dist-out 19.046 APE9-dist-out 10.592 None None None XRAY 2.4 0.184 0.25 A 298 290 8 0 0 0 [[4, 286]] 1.0 3lfs CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3NS9A 3 298 298.0 NS9:0 Type1 Inactive DFGin 10.655 18.344 BLBtrans -104.88, 159.9 69.13, 14.3 -58.32, 131.05 228.88, 99.89 85.42, -14.57 out-out out 15.329 Saltbr-out 15.457 HRD-in -88.02, -56.06 83.3, -13.93 out-out-out SNCooo out-out ActLoopNT-out 5.779 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.64, 135.86 APE9-dihe-na -78.78, 127.68 APE8-dihe-in -68.37, 143.21 APE8-rot-out 190.5 APE67-dihe-in -63.73, -24.13 -102.59, -2.72 APE12-dist-out 19.632 APE11-dist-out 17.29 APE10-dist-out 18.722 APE9-dist-out 10.33 None None None XRAY 1.78 0.205 0.265 A 298 289 7 0 0 0 [[4, 286]] 1.0 3ns9 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3S2PA 1 298 298.0 PMU:500 Type1 Inactive DFGin 10.728 18.276 BLBtrans -115.59, 143.64 80.48, 18.95 -63.27, 136.01 232.47, 114.59 83.89, -19.44 out-out out 14.943 Saltbr-out 14.624 HRD-in -88.04, -38.7 71.57, -19.54 out-out-out SNCooo out-out ActLoopNT-out 5.871 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -22.9 APE8-dihe-in -78.72, 142.39 APE8-rot-in 309.29 APE67-dihe-in -55.83, -25.33 -114.08, 1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.855 None None None XRAY 2.3 0.246 0.304 A 298 279 19 0 0 11 [[4, 286]] 1.0 3s2p CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3ULIA 1 298 298.0 1N3:299 Type1 Inactive DFGin 9.095 16.895 BLBtrans -122.4, 161.11 57.18, 61.42 -118.68, 96.88 197.31, 137.98 93.34, 2.37 out-out out 14.413 Saltbr-out 13.533 HRD-in -84.65, -55.09 88.22, -19.73 out-out-out SNCooo out-out ActLoopNT-out 6.956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -96.78, 120.01 APE9-dihe-na -69.02, 130.04 APE8-dihe-in -74.02, 136.57 APE8-rot-out 192.05 APE67-dihe-in -63.89, -25.25 -105.81, -1.83 APE12-dist-none 999.0 APE11-dist-out 15.627 APE10-dist-out 19.206 APE9-dist-out 10.563 None None None XRAY 2.0 0.253 0.302 A 298 286 12 0 0 7 [[4, 286]] 1.0 3uli CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3WBLA 1 298 298.0 PDY:302 Type1 Inactive DFGin 10.717 18.373 BLBtrans -103.8, 149.14 67.3, 26.93 -65.23, 140.5 227.39, 108.94 72.84, -9.33 out-out out 14.984 Saltbr-out 15.276 HRD-in -83.29, -54.84 80.46, -20.85 out-out-out SNCooo out-out ActLoopNT-out 5.854 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 114.58 APE9-dihe-na -78.48, 139.33 APE8-dihe-in -74.02, 136.95 APE8-rot-out 196.91 APE67-dihe-in -56.18, -27.92 -102.18, -5.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.257 APE9-dist-out 10.48 None None None XRAY 2.0 0.192 0.249 A 298 283 15 0 0 9 [[4, 286]] 1.0 3wbl CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4LYNA 1 298 298.0 1YG:301 Type1 Inactive DFGin 10.516 18.235 BLBtrans -119.41, 150.82 73.54, 17.17 -63.03, 136.35 224.83, 109.35 65.09, -1.73 out-out out 15.029 Saltbr-out 14.755 HRD-in -80.09, -54.97 80.22, -21.72 out-out-out SNCooo out-out ActLoopNT-out 6.015 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 138.69 APE8-dihe-in -72.27, 124.76 APE8-rot-out 163.4 APE67-dihe-in -51.14, -32.54 -100.42, -8.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.897 None None None XRAY 2.0 0.187 0.238 A 298 287 11 0 0 11 [[4, 286]] 1.0 4lyn CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4RJ3A 1 295 298.0 3QS:302 Type1 Inactive DFGin 10.844 18.479 BLBtrans -103.26, 157.57 67.1, 20.45 -61.5, 131.71 229.9, 107.13 88.12, -11.06 out-na out 15.245 Saltbr-na 16.015 HRD-in -86.0, -60.04 83.03, -12.63 na-out-out SNCaoo out-out ActLoopNT-out 5.662 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.8, 126.77 APE9-dihe-na -74.75, 124.45 APE8-dihe-in -64.43, 140.32 APE8-rot-out 189.03 APE67-dihe-in -62.82, -26.74 -95.98, -4.59 APE12-dist-out 19.57 APE11-dist-out 17.127 APE10-dist-out 18.661 APE9-dist-out 10.283 None None ALY33 XRAY 1.63 0.177 0.21 A 298 288 7 0 0 0 [[4, 286]] 1.0 4rj3 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5ANDA 2 294 298.0 5JE:1295 Type1 Inactive DFGin 8.274 17.972 BLBtrans -108.56, 154.71 65.26, 24.96 -64.51, 124.84 179.06, 87.03 79.75, -8.42 out-out out 15.275 Saltbr-out 16.992 HRD-in -83.51, -57.35 86.6, -15.4 out-out-out SNCooo out-out ActLoopNT-out 6.246 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 139.45 APE8-dihe-in -89.16, 125.83 APE8-rot-out 204.61 APE67-dihe-in -61.14, -27.5 -92.29, -6.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.133 None None None XRAY 2.3 0.202 0.243 A 298 273 20 0 0 11 [[4, 286]] 1.0 5and CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5ANEA 1 298 298.0 SZL:1299 Type1 Inactive DFGin 10.384 18.042 BLBtrans -98.72, 153.51 62.76, 28.13 -66.67, 130.51 214.15, 104.62 78.54, -1.94 out-out out 14.978 Saltbr-out 17.607 HRD-in -83.35, -63.25 85.3, -7.09 out-out-out SNCooo out-out ActLoopNT-out 5.652 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.52, 131.48 APE9-dihe-na -77.43, 129.29 APE8-dihe-in -69.37, 142.37 APE8-rot-out 187.45 APE67-dihe-in -63.2, -24.6 -96.92, -3.93 APE12-dist-out 19.525 APE11-dist-out 17.429 APE10-dist-out 18.735 APE9-dist-out 9.926 None None None XRAY 1.7 0.207 0.252 A 298 294 4 0 0 0 [[4, 286]] 1.0 5ane CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5ANIA 2 298 298.0 ES4:1299 Type1 Inactive DFGin 8.632 17.921 BLBtrans -100.22, 154.97 64.79, 25.57 -66.16, 128.59 185.17, 94.4 81.8, -7.51 out-out out 15.17 Saltbr-out 18.472 HRD-in -83.13, -60.29 85.98, -16.81 out-out-out SNCooo out-out ActLoopNT-out 5.965 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 138.49 APE9-dihe-na -86.69, 143.39 APE8-dihe-in -86.45, 133.92 APE8-rot-out 194.21 APE67-dihe-in -62.06, -24.3 -102.02, -7.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.068 APE9-dist-out 10.904 None None None XRAY 1.9 0.19 0.233 A 298 280 17 0 0 8 [[4, 286]] 1.0 5ani CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5ANJA 3 298 298.0 ZXC:1299 Type1 Inactive DFGin 10.316 18.422 BLBtrans -96.15, 156.02 57.87, 34.07 -67.32, 126.98 208.38, 110.65 85.39, -7.11 out-out out 15.054 Saltbr-out 17.717 HRD-in -88.18, -56.56 82.52, -15.71 out-out-out SNCooo out-out ActLoopNT-out 5.823 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 135.53 APE9-dihe-na -80.24, 130.39 APE8-dihe-in -72.89, 137.17 APE8-rot-out 186.19 APE67-dihe-in -62.47, -26.78 -99.52, -0.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.984 APE9-dist-out 10.461 None None None XRAY 1.6 0.198 0.229 A 298 291 5 0 0 5 [[4, 286]] 1.0 5anj CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5ANKA 1 298 298.0 RJI:1299 Type1 Inactive DFGin 10.004 18.262 BLBtrans -94.59, 160.52 54.33, 28.13 -69.08, 123.46 208.1, 104.38 89.59, -12.34 out-out out 15.344 Saltbr-out 16.947 HRD-in -82.34, -53.27 72.78, -5.2 out-out-none SNCoon out-none ActLoopNT-out 5.967 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -17.3 APE8-rot-in 304.08 APE67-dihe-in -62.45, -25.31 -60.66, -15.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.197 0.236 A 298 273 25 0 0 12 [[4, 286]] 1.0 5ank CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5IEYA 1 298 298.0 6AE:1001 Type1 Inactive DFGin 10.378 18.215 BLBtrans -114.62, 155.0 62.49, 29.46 -64.65, 133.15 216.83, 113.7 77.69, -6.71 out-out out 14.9 Saltbr-out 14.376 HRD-in -75.94, -63.93 88.74, -13.91 out-out-out SNCooo out-out ActLoopNT-out 5.849 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -87.07, 134.96 APE9-dihe-na -69.57, 124.98 APE8-dihe-in -77.94, 129.25 APE8-rot-out 189.15 APE67-dihe-in -64.17, -21.6 -99.11, -0.55 APE12-dist-none 999.0 APE11-dist-out 18.559 APE10-dist-out 19.237 APE9-dist-out 10.704 None None None XRAY 1.66 0.182 0.225 A 298 286 12 0 0 7 [[4, 286]] 1.0 5iey CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5JQ8A 3 298 298.0 I73:301 Type1 Inactive DFGin 10.584 18.345 BLBtrans -111.9, 145.9 71.11, 24.04 -62.19, 135.44 225.71, 101.49 76.75, -12.86 out-out out 15.069 Saltbr-out 16.494 HRD-in -81.24, -58.14 82.22, -19.75 out-out-out SNCooo out-out ActLoopNT-out 6.036 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -72.45, 129.84 APE9-dihe-na -73.44, 132.24 APE8-dihe-in -75.97, 146.79 APE8-rot-out 187.32 APE67-dihe-in -56.28, -25.19 -112.71, -4.11 APE12-dist-none 999.0 APE11-dist-out 17.147 APE10-dist-out 19.094 APE9-dist-out 10.404 None None None XRAY 1.94 0.197 0.26 A 298 278 18 0 0 9 [[4, 286]] 1.0 5jq8 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6OQIA 1 298 298.0 N14:60301 Type1 Inactive DFGin 9.145 17.407 BLBtrans -126.28, 165.47 59.89, 41.19 -98.84, 122.93 208.17, 144.57 85.1, -12.85 out-out out 15.094 Saltbr-out 14.724 HRD-in -85.38, -45.99 73.3, -6.92 out-out-out SNCooo out-out ActLoopNT-out 6.081 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.72, 136.48 APE9-dihe-na -75.41, 131.36 APE8-dihe-in -71.47, 141.69 APE8-rot-out 182.19 APE67-dihe-in -60.02, -23.25 -107.84, 1.42 APE12-dist-out 19.791 APE11-dist-out 17.627 APE10-dist-out 19.004 APE9-dist-out 10.274 None None None XRAY 2.0 0.2 0.241 A 299 289 9 0 0 0 [[4, 286]] 1.0 6oqi CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8ERNA 1 296 298.0 WQK:60402 Type1 Inactive DFGin 10.439 18.378 BLBtrans -118.55, 157.59 63.45, 35.55 -78.63, 124.58 219.79, 122.83 82.3, -1.34 out-out out 15.638 Saltbr-out 14.653 HRD-in -80.71, -57.4 84.12, -13.85 out-out-out SNCooo out-out ActLoopNT-out 6.128 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.52, 126.92 APE9-dihe-na -73.22, 136.0 APE8-dihe-in -74.96, 142.36 APE8-rot-out 180.44 APE67-dihe-in -62.96, -25.44 -103.97, -1.56 APE12-dist-out 19.887 APE11-dist-out 17.61 APE10-dist-out 19.181 APE9-dist-out 10.636 None None None XRAY 1.64 0.21 0.25 A 299 287 9 0 0 0 [[4, 286]] 1.0 8ern CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5K4JA 1 298 298.0 6QB:60301 Type1 Inactive DFGin 10.014 17.968 BLBtrans -110.55, 159.76 77.32, 19.32 -71.27, 128.01 213.83, 116.19 78.16, -4.69 out-out out 14.877 Saltbr-out 14.447 HRD-in -79.41, -50.42 77.08, -15.7 out-out-out SNCooo out-out ActLoopNT-out 6.011 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -80.0, 132.4 APE9-dihe-na -74.94, 130.59 APE8-dihe-in -80.35, 134.59 APE8-rot-in 295.11 APE67-dihe-in -60.39, -27.31 -100.79, -3.91 APE12-dist-none 999.0 APE11-dist-out 16.727 APE10-dist-out 19.117 APE9-dist-out 10.736 None None None XRAY 1.6 0.18 0.223 A 299 281 17 0 0 10 [[4, 286]] 1.0 5k4j CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1E1VA 1 298 298.0 CMG:60401 Type1 Inactive DFGin 10.7 18.046 BLBtrans -99.24, 155.81 66.87, 24.14 -63.76, 132.18 229.6, 99.82 83.4, -10.92 out-out out 14.791 Saltbr-out 16.833 HRD-in -80.59, -61.19 86.42, -5.25 out-out-out SNCooo out-out ActLoopNT-out 5.888 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.29, 122.71 APE9-dihe-na -66.44, 133.05 APE8-dihe-in -66.6, 142.89 APE8-rot-out 188.61 APE67-dihe-in -57.66, -27.27 -107.35, -0.77 APE12-dist-out 20.128 APE11-dist-out 17.342 APE10-dist-out 18.833 APE9-dist-out 10.254 None None None XRAY 1.95 0.195 0.269 A 299 290 8 0 0 0 [[4, 286]] 1.0 1e1v CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1E1XA 1 298 298.0 NW1:60401 Type1 Inactive DFGin 10.979 17.956 BLBtrans -97.64, 157.77 73.06, 19.32 -55.26, 128.79 234.68, 94.87 75.71, 0.85 out-out out 15.081 Saltbr-out 16.453 HRD-in -92.2, -60.79 83.98, -15.99 out-out-out SNCooo out-out ActLoopNT-out 5.821 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.82, 129.95 APE9-dihe-na -80.61, 134.6 APE8-dihe-in -68.67, 134.93 APE8-rot-out 196.27 APE67-dihe-in -57.95, -23.37 -105.9, -3.99 APE12-dist-out 19.47 APE11-dist-out 17.167 APE10-dist-out 18.93 APE9-dist-out 10.403 None None None XRAY 1.85 0.213 0.281 A 299 290 8 0 0 0 [[4, 286]] 1.0 1e1x CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1GZ8A 1 298 298.0 MBP:1300 Type1 Inactive DFGin 10.443 18.109 BLBtrans -98.58, 152.57 68.89, 22.47 -64.14, 134.1 219.68, 102.93 81.1, -7.16 out-out out 15.044 Saltbr-out 16.271 HRD-in -86.73, -59.22 79.55, -11.88 out-out-out SNCooo out-out ActLoopNT-out 5.744 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.59, 127.96 APE9-dihe-na -76.18, 124.54 APE8-dihe-in -65.03, 145.76 APE8-rot-out 188.09 APE67-dihe-in -62.43, -28.35 -100.67, -3.14 APE12-dist-out 19.918 APE11-dist-out 17.207 APE10-dist-out 18.672 APE9-dist-out 10.014 None None CSD177 XRAY 1.3 0.153 0.185 A 299 291 7 0 0 0 [[4, 286]] 1.0 1gz8 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OIQA 1 298 298.0 HDU:1299 Type1 Inactive DFGin 10.525 18.059 BLBtrans -139.58, 159.59 69.1, 6.46 -54.74, 137.73 236.8, 108.11 72.21, -12.12 out-out out 14.532 Saltbr-out 14.63 HRD-in -87.74, -56.39 87.44, -26.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.92 APE8-rot-out 189.02 APE67-dihe-in -62.46, -30.39 -108.24, -1.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.229 0.271 A 299 264 34 0 0 16 [[4, 286]] 1.0 1oiq CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1OIRA 1 296 298.0 HDY:1298 Type1 Inactive DFGin 10.961 18.565 BLBtrans -105.21, 158.89 70.84, 20.35 -62.04, 126.74 235.25, 106.34 88.7, -8.69 out-na out 15.74 Saltbr-na 16.69 HRD-in -85.97, -61.94 84.44, -12.99 na-out-out SNCaoo out-out ActLoopNT-out 5.635 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.94, 129.22 APE9-dihe-na -76.3, 127.65 APE8-dihe-in -68.45, 143.36 APE8-rot-out 185.35 APE67-dihe-in -63.04, -26.93 -100.98, -1.1 APE12-dist-out 19.443 APE11-dist-out 17.064 APE10-dist-out 18.737 APE9-dist-out 10.536 None None KCX33 XRAY 1.91 0.205 0.241 A 299 287 9 0 0 0 [[4, 286]] 1.0 1oir CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1URWA 1 298 298.0 I1P:61300 Type1 Inactive DFGin 10.454 17.886 BLBtrans -128.9, 152.71 71.9, 33.22 -81.51, 142.79 224.2, 128.23 67.48, -23.02 out-out out 14.801 Saltbr-out 12.24 HRD-in -84.68, -54.56 83.53, -20.34 out-out-out SNCooo out-out ActLoopNT-out 6.051 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 131.56 APE9-dihe-na -78.51, 139.82 APE8-dihe-in -86.11, 137.85 APE8-rot-out 183.94 APE67-dihe-in -50.76, -31.17 -107.42, -3.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.876 APE9-dist-out 11.04 None None None XRAY 1.6 0.22 0.253 A 299 274 24 0 0 11 [[4, 286]] 1.0 1urw CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1V1KA 1 298 298.0 3FP:60299 Type1 Inactive DFGin 10.19 17.621 BLBtrans -125.57, 168.64 54.61, 23.05 -54.4, -165.85 213.64, 99.56 -28.29, 96.36 out-out out 15.372 Saltbr-out 10.793 HRD-in -81.8, -52.45 88.54, -21.37 out-out-out SNCooo out-out ActLoopNT-out 8.562 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 123.05 APE9-dihe-na -65.42, 144.62 APE8-dihe-in -94.98, 131.83 APE8-rot-out 161.28 APE67-dihe-in -57.88, -24.5 -103.16, -2.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.248 APE9-dist-out 11.137 None None None XRAY 2.31 0.211 0.269 A 299 277 21 0 0 12 [[4, 286]] 1.0 1v1k CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1W8CA 1 298 298.0 N69:61301 Type1 Inactive DFGin 10.642 18.343 BLBtrans -101.18, 151.28 67.51, 27.92 -61.57, 133.85 226.8, 104.35 84.98, -14.28 out-out out 14.911 Saltbr-out 16.63 HRD-in -85.85, -58.86 84.89, -17.12 out-out-out SNCooo out-out ActLoopNT-out 5.894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -80.73, 123.43 APE9-dihe-na -69.45, 127.62 APE8-dihe-in -68.1, 141.07 APE8-rot-out 186.57 APE67-dihe-in -57.74, -30.12 -102.87, -3.74 APE12-dist-out 20.129 APE11-dist-out 17.389 APE10-dist-out 18.999 APE9-dist-out 10.328 None None CSD177 XRAY 2.05 0.199 0.256 A 299 291 7 0 0 0 [[4, 286]] 1.0 1w8c CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3FA 1 298 298.0 SC8:60501 Type1 Inactive DFGin 10.661 18.447 BLBtrans -98.47, 153.7 67.12, 23.77 -63.21, 134.87 222.5, 102.49 84.2, -12.67 out-out out 15.069 Saltbr-out 16.376 HRD-in -92.88, -57.06 79.84, -15.25 out-out-out SNCooo out-out ActLoopNT-out 5.778 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.33, 129.66 APE9-dihe-na -76.76, 123.22 APE8-dihe-in -59.98, 142.46 APE8-rot-out 189.43 APE67-dihe-in -55.63, -29.96 -99.21, -7.24 APE12-dist-out 19.988 APE11-dist-out 17.381 APE10-dist-out 18.745 APE9-dist-out 10.084 None None None XRAY 1.5 0.205 0.236 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3f CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3GA 1 298 298.0 SC9:60501 Type1 Inactive DFGin 10.85 18.044 BLBtrans -101.2, 155.63 64.03, 23.98 -61.34, 131.64 231.22, 103.88 83.95, -10.27 out-out out 15.05 Saltbr-out 15.854 HRD-in -90.77, -53.86 83.23, -20.56 out-out-out SNCooo out-out ActLoopNT-out 5.869 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.39, 131.88 APE9-dihe-na -79.4, 124.0 APE8-dihe-in -61.77, 143.17 APE8-rot-out 188.75 APE67-dihe-in -55.58, -28.19 -102.38, -7.58 APE12-dist-out 19.601 APE11-dist-out 17.184 APE10-dist-out 18.542 APE9-dist-out 10.37 None None None XRAY 1.55 0.182 0.212 A 299 289 9 0 0 0 [[4, 286]] 1.0 2r3g CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3HA 1 298 298.0 SCE:60501 Type1 Inactive DFGin 10.487 18.05 BLBtrans -103.52, 151.95 66.45, 22.94 -59.13, 127.46 225.8, 104.72 85.98, -12.37 out-out out 15.001 Saltbr-out 15.445 HRD-in -89.0, -57.65 85.02, -19.12 out-out-out SNCooo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -56.14, 129.68 APE9-dihe-na -79.54, 125.55 APE8-dihe-in -64.01, 138.16 APE8-rot-out 192.6 APE67-dihe-in -56.96, -27.59 -101.19, -4.49 APE12-dist-out 19.454 APE11-dist-out 16.941 APE10-dist-out 18.679 APE9-dist-out 10.383 None None None XRAY 1.5 0.196 0.219 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3h CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3IA 1 298 298.0 SCF:60501 Type1 Inactive DFGin 10.929 18.24 BLBtrans -100.61, 149.54 71.45, 21.63 -58.2, 134.86 231.09, 103.4 83.18, -10.48 out-out out 15.057 Saltbr-out 16.345 HRD-in -91.01, -59.76 82.13, -15.3 out-out-out SNCooo out-out ActLoopNT-out 5.707 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.45, 127.61 APE9-dihe-na -74.97, 122.45 APE8-dihe-in -60.32, 144.67 APE8-rot-out 191.76 APE67-dihe-in -59.78, -26.25 -99.25, -5.87 APE12-dist-out 20.169 APE11-dist-out 17.538 APE10-dist-out 18.889 APE9-dist-out 9.991 None None CSD177 XRAY 1.28 0.178 0.202 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3i CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3JA 1 298 298.0 SCJ:60501 Type1 Inactive DFGin 10.953 18.27 BLBtrans -114.1, 146.32 72.9, 23.15 -65.23, 137.05 227.18, 118.23 77.67, -8.73 out-out out 14.942 Saltbr-out 13.278 HRD-in -88.62, -56.28 83.59, -20.34 out-out-out SNCooo out-out ActLoopNT-out 5.848 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -67.21, 131.74 APE9-dihe-na -77.49, 130.71 APE8-dihe-in -68.83, 135.15 APE8-rot-out 195.06 APE67-dihe-in -55.89, -31.05 -103.35, -2.48 APE12-dist-none 999.0 APE11-dist-out 17.275 APE10-dist-out 19.234 APE9-dist-out 10.554 None None CSD177 XRAY 1.65 0.2 0.236 A 299 282 16 0 0 9 [[4, 286]] 1.0 2r3j CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3KA 1 298 298.0 SCQ:60501 Type1 Inactive DFGin 10.642 18.225 BLBtrans -112.38, 153.22 66.63, 25.1 -65.21, 140.32 227.57, 108.04 67.95, -4.84 out-out out 14.969 Saltbr-out 13.736 HRD-in -85.09, -56.84 80.01, -16.78 out-out-out SNCooo out-out ActLoopNT-out 5.831 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na -72.41, 132.59 APE9-dihe-na -78.48, 130.63 APE8-dihe-in -67.26, 135.75 APE8-rot-out 191.27 APE67-dihe-in -52.65, -28.86 -102.21, -4.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.209 APE9-dist-out 10.563 None None CSD177 XRAY 1.7 0.19 0.232 A 299 281 17 0 0 10 [[4, 286]] 1.0 2r3k CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3MA 1 298 298.0 SCX:60501 Type1 Inactive DFGin 10.336 17.989 BLBtrans -114.44, 154.5 64.36, 27.21 -64.77, 129.58 219.81, 110.11 75.78, 0.59 out-out out 14.779 Saltbr-out 13.304 HRD-in -83.44, -56.39 84.88, -17.86 out-out-out SNCooo out-out ActLoopNT-out 5.822 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -73.86, 131.01 APE9-dihe-na -80.36, 124.34 APE8-dihe-in -63.19, 139.82 APE8-rot-out 192.11 APE67-dihe-in -55.39, -28.8 -104.94, -1.79 APE12-dist-none 999.0 APE11-dist-out 16.986 APE10-dist-out 18.79 APE9-dist-out 10.433 None None CSD177 XRAY 1.7 0.187 0.216 A 299 282 16 0 0 9 [[4, 286]] 1.0 2r3m CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3OA 1 298 298.0 2SC:60501 Type1 Inactive DFGin 10.907 18.264 BLBtrans -106.8, 151.12 69.21, 20.64 -59.53, 130.76 233.37, 103.94 83.35, -14.32 out-out out 15.041 Saltbr-out 16.015 HRD-in -88.12, -55.73 82.99, -17.8 out-out-out SNCooo out-out ActLoopNT-out 5.774 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.63, 134.1 APE9-dihe-na -80.22, 121.22 APE8-dihe-in -57.69, 141.45 APE8-rot-out 195.73 APE67-dihe-in -53.3, -28.47 -106.6, -7.16 APE12-dist-out 19.367 APE11-dist-out 17.274 APE10-dist-out 18.543 APE9-dist-out 10.256 None None CSD177 XRAY 1.8 0.189 0.227 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3o CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3PA 1 298 298.0 3SC:60501 Type1 Inactive DFGin 10.373 18.096 BLBtrans -103.73, 154.65 64.46, 27.74 -66.14, 127.17 219.16, 108.22 87.15, -11.8 out-out out 14.968 Saltbr-out 15.549 HRD-in -87.03, -56.62 81.22, -14.37 out-out-out SNCooo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.35, 131.64 APE9-dihe-na -77.8, 130.25 APE8-dihe-in -65.87, 140.83 APE8-rot-out 194.97 APE67-dihe-in -52.22, -31.79 -106.34, -5.59 APE12-dist-out 19.7 APE11-dist-out 17.11 APE10-dist-out 18.702 APE9-dist-out 10.279 None None CSD177 XRAY 1.66 0.187 0.226 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3p CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3QA 1 298 298.0 5SC:60501 Type1 Inactive DFGin 10.512 18.433 BLBtrans -100.67, 151.77 68.64, 21.38 -59.6, 132.77 219.86, 104.61 84.62, -10.28 out-out out 15.164 Saltbr-out 16.381 HRD-in -90.07, -58.44 81.19, -13.46 out-out-out SNCooo out-out ActLoopNT-out 5.722 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.87, 130.09 APE9-dihe-na -75.81, 120.33 APE8-dihe-in -59.08, 142.08 APE8-rot-out 190.22 APE67-dihe-in -58.29, -27.52 -99.28, -5.18 APE12-dist-out 19.775 APE11-dist-out 17.289 APE10-dist-out 18.687 APE9-dist-out 9.959 None None CSD177 XRAY 1.35 0.182 0.202 A 299 289 9 0 0 0 [[4, 286]] 1.0 2r3q CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2W06A 1 298 298.0 FRV:61300 Type1 Inactive DFGin 10.9 18.235 BLBtrans -114.95, 157.61 70.96, 19.37 -66.23, 138.0 226.94, 104.29 76.65, -14.89 out-none out 14.963 Saltbr-none 999.0 HRD-in -90.02, -58.32 84.99, -24.63 none-out-out SNCnoo out-out ActLoopNT-out 5.567 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -86.7, 128.97 APE9-dihe-na -67.97, 140.58 APE8-dihe-in -73.49, 145.56 APE8-rot-out 189.77 APE67-dihe-in -52.32, -34.55 -110.41, 0.62 APE12-dist-none 999.0 APE11-dist-out 18.754 APE10-dist-out 19.51 APE9-dist-out 10.719 None None None XRAY 2.04 0.205 0.234 A 299 282 16 0 0 9 [[4, 286]] 1.0 2w06 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3IG7A 1 298 298.0 EFP:60999 Type1 Inactive DFGin 8.213 17.453 BLBtrans -132.35, 160.03 82.32, -1.99 -50.89, 132.61 196.98, 90.02 72.2, -15.62 out-out out 15.34 Saltbr-out 13.163 HRD-in -72.58, -55.68 84.16, -21.53 out-out-out SNCooo out-out ActLoopNT-out 6.168 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 117.09 APE8-rot-out 182.06 APE67-dihe-in -57.64, -23.91 -98.67, -5.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.209 0.257 A 299 278 20 0 0 12 [[4, 286]] 1.0 3ig7 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4ACMA 1 298 298.0 7YG:61302 Type1 Inactive DFGin 10.781 17.965 BLBtrans -112.58, 148.13 72.17, 28.34 -71.04, 117.13 228.95, 112.04 92.36, -0.32 out-none out 15.008 Saltbr-none 999.0 HRD-in -83.27, -56.83 80.89, -15.76 none-out-out SNCnoo out-out ActLoopNT-out 6.149 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 127.54 APE9-dihe-na -64.12, 121.26 APE8-dihe-in -82.01, 126.96 APE8-rot-in 299.69 APE67-dihe-in -52.71, -31.21 -101.9, -6.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.25 APE9-dist-out 10.881 None None None XRAY 1.63 0.185 0.218 A 299 277 21 0 0 12 [[4, 286]] 1.0 4acm CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EK4A 1 296 298.0 1CK:60301 Type1 Inactive DFGin 10.854 18.329 BLBtrans -100.51, 149.8 72.56, 21.33 -57.59, 137.23 234.06, 103.31 81.08, -10.77 out-out out 15.148 Saltbr-out 17.273 HRD-in -86.4, -60.53 82.79, -14.27 out-out-out SNCooo out-out ActLoopNT-out 5.843 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.97, 126.3 APE9-dihe-na -70.85, 129.02 APE8-dihe-in -66.37, 143.77 APE8-rot-out 189.09 APE67-dihe-in -62.27, -27.5 -99.35, -4.14 APE12-dist-out 20.076 APE11-dist-out 17.438 APE10-dist-out 18.841 APE9-dist-out 10.451 None None None XRAY 1.26 0.158 0.184 A 299 287 9 0 0 0 [[4, 286]] 1.0 4ek4 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EK5A 1 298 298.0 03K:60300 Type1 Inactive DFGin 10.921 18.188 BLBtrans -103.77, 152.42 71.03, 21.11 -61.03, 129.99 236.67, 103.22 85.82, -10.8 out-out out 15.004 Saltbr-out 13.63 HRD-in -88.04, -55.76 82.49, -18.49 out-out-out SNCooo out-out ActLoopNT-out 5.972 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.4, 128.7 APE9-dihe-na -73.93, 129.76 APE8-dihe-in -67.04, 137.47 APE8-rot-out 192.08 APE67-dihe-in -58.4, -25.9 -100.33, -4.35 APE12-dist-out 20.111 APE11-dist-out 17.298 APE10-dist-out 18.875 APE9-dist-out 10.552 None None None XRAY 1.6 0.177 0.213 A 299 289 9 0 0 0 [[4, 286]] 1.0 4ek5 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EK6A 1 298 298.0 10K:60301 Type1 Inactive DFGin 10.628 18.054 BLBtrans -108.06, 151.93 70.38, 25.25 -61.93, 130.69 232.32, 109.81 80.42, -8.66 out-out out 15.129 Saltbr-out 16.008 HRD-in -86.6, -55.48 82.58, -16.89 out-out-out SNCooo out-out ActLoopNT-out 5.969 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -76.95, 130.77 APE9-dihe-na -76.53, 127.18 APE8-dihe-in -67.2, 137.66 APE8-rot-out 188.94 APE67-dihe-in -59.63, -26.39 -102.15, -1.88 APE12-dist-none 999.0 APE11-dist-out 17.279 APE10-dist-out 18.893 APE9-dist-out 10.439 None None None XRAY 1.52 0.189 0.217 A 299 278 20 0 0 10 [[4, 286]] 1.0 4ek6 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4EK8A 1 298 298.0 16K:60301 Type1 Inactive DFGin 10.722 17.995 BLBtrans -109.5, 155.95 67.88, 29.38 -68.08, 131.38 233.17, 108.24 75.4, -2.75 out-out out 15.148 Saltbr-out 15.944 HRD-in -85.31, -57.76 81.42, -13.21 out-out-out SNCooo out-out ActLoopNT-out 5.913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -85.83, 126.82 APE9-dihe-na -73.32, 127.39 APE8-dihe-in -69.57, 137.21 APE8-rot-out 187.88 APE67-dihe-in -57.43, -25.99 -100.18, -2.52 APE12-dist-none 999.0 APE11-dist-out 17.35 APE10-dist-out 19.192 APE9-dist-out 10.632 None None None XRAY 1.7 0.184 0.215 A 299 281 17 0 0 9 [[4, 286]] 1.0 4ek8 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKGA 1 298 298.0 4CK:60300 Type1 Inactive DFGin 10.936 18.139 BLBtrans -107.41, 153.36 71.13, 22.31 -63.63, 131.11 235.19, 106.34 82.01, -10.12 out-out out 15.077 Saltbr-out 15.468 HRD-in -87.55, -54.08 81.9, -19.96 out-out-out SNCooo out-out ActLoopNT-out 5.947 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.5, 129.23 APE9-dihe-na -75.39, 128.68 APE8-dihe-in -65.92, 137.73 APE8-rot-out 192.39 APE67-dihe-in -57.48, -27.01 -101.94, -3.79 APE12-dist-out 20.127 APE11-dist-out 17.457 APE10-dist-out 18.995 APE9-dist-out 10.49 None None None XRAY 1.51 0.181 0.209 A 299 286 12 0 0 3 [[4, 286]] 1.0 4fkg CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKIA 1 298 298.0 09K:60301 Type1 Inactive DFGin 10.65 18.18 BLBtrans -106.3, 156.63 67.77, 23.12 -61.4, 126.08 229.96, 109.03 82.55, -7.62 out-out out 15.135 Saltbr-out 16.137 HRD-in -86.67, -56.22 82.47, -16.53 out-out-out SNCooo out-out ActLoopNT-out 5.964 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.61, 130.76 APE9-dihe-na -76.57, 129.21 APE8-dihe-in -70.96, 140.03 APE8-rot-out 186.94 APE67-dihe-in -58.1, -24.75 -101.35, -4.88 APE12-dist-out 19.994 APE11-dist-out 17.27 APE10-dist-out 18.828 APE9-dist-out 10.469 None None None XRAY 1.6 0.175 0.198 A 299 287 11 0 0 3 [[4, 286]] 1.0 4fki CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKJA 1 298 298.0 11K:60301 Type1 Inactive DFGin 10.662 18.118 BLBtrans -106.54, 153.3 70.49, 22.57 -62.76, 127.65 230.35, 110.34 77.74, -2.81 out-out out 14.989 Saltbr-out 16.068 HRD-in -84.91, -56.08 81.47, -18.87 out-out-out SNCooo out-out ActLoopNT-out 5.971 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 126.64 APE9-dihe-na -72.37, 129.36 APE8-dihe-in -70.49, 135.34 APE8-rot-out 194.64 APE67-dihe-in -57.08, -26.19 -100.53, -4.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.018 APE9-dist-out 10.548 None None None XRAY 1.63 0.181 0.199 A 299 278 20 0 0 11 [[4, 286]] 1.0 4fkj CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKLA 1 298 298.0 CK2:60300 Type1 Inactive DFGin 10.298 18.454 BLBtrans -97.13, 153.97 64.33, 26.38 -63.89, 127.59 213.16, 110.01 88.41, -9.74 out-out out 15.155 Saltbr-out 16.365 HRD-in -87.84, -59.51 78.56, -8.39 out-out-out SNCooo out-out ActLoopNT-out 5.856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.65, 125.71 APE9-dihe-na -71.35, 128.91 APE8-dihe-in -66.94, 143.31 APE8-rot-out 189.68 APE67-dihe-in -62.22, -28.04 -98.08, -4.44 APE12-dist-out 20.01 APE11-dist-out 17.245 APE10-dist-out 18.752 APE9-dist-out 10.243 None None None XRAY 1.26 0.153 0.183 A 299 291 7 0 0 0 [[4, 286]] 1.0 4fkl CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKPA 1 298 298.0 LS5:60301 Type1 Inactive DFGin 10.421 18.13 BLBtrans -109.07, 148.66 68.57, 31.4 -65.98, 130.02 221.71, 113.06 77.11, -6.92 out-out out 15.119 Saltbr-out 13.261 HRD-in -84.61, -56.13 82.12, -17.36 out-out-out SNCooo out-out ActLoopNT-out 5.982 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 128.13 APE9-dihe-na -65.92, 132.4 APE8-dihe-in -77.18, 137.03 APE8-rot-out 191.59 APE67-dihe-in -56.87, -27.63 -103.85, -4.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.971 APE9-dist-out 10.405 None None None XRAY 1.6 0.185 0.198 A 299 280 18 0 0 10 [[4, 286]] 1.0 4fkp CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKSA 1 296 298.0 46K:60301 Type1 Inactive DFGin 10.828 18.454 BLBtrans -112.06, 149.48 76.57, 20.63 -65.19, 118.75 230.2, 112.05 97.77, -20.35 out-out out 14.989 Saltbr-out 15.227 HRD-in -82.97, -55.97 81.27, -16.68 out-out-out SNCooo out-out ActLoopNT-out 5.952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 131.96 APE9-dihe-na -72.82, 130.43 APE8-dihe-in -72.15, 135.06 APE8-rot-in 310.37 APE67-dihe-in -59.08, -28.91 -101.44, -2.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.169 APE9-dist-out 10.452 None None None XRAY 1.55 0.171 0.183 A 299 275 21 0 0 12 [[4, 286]] 1.0 4fks CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKTA 1 296 298.0 48K:60301 Type1 Inactive DFGin 10.351 18.046 BLBtrans -109.44, 151.1 67.45, 31.19 -67.7, 128.25 218.22, 118.65 80.97, -8.61 out-out out 15.074 Saltbr-out 15.936 HRD-in -83.89, -55.16 81.06, -15.22 out-out-out SNCooo out-out ActLoopNT-out 5.878 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -83.89, 130.3 APE9-dihe-na -71.98, 135.08 APE8-dihe-in -74.64, 138.23 APE8-rot-out 192.64 APE67-dihe-in -58.77, -28.14 -101.27, -2.22 APE12-dist-none 999.0 APE11-dist-out 17.103 APE10-dist-out 18.916 APE9-dist-out 10.396 None None None XRAY 1.6 0.169 0.193 A 299 278 18 0 0 9 [[4, 286]] 1.0 4fkt CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKVA 1 298 298.0 61K:60301 Type1 Inactive DFGin 9.697 17.074 BLBtrans -116.24, 166.42 56.68, 49.13 -66.21, -125.25 234.55, 108.89 -63.2, 29.87 out-out out 15.073 Saltbr-out 14.013 HRD-in -80.3, -55.19 82.8, -16.39 out-out-out SNCooo out-out ActLoopNT-out 6.264 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -87.01, 128.94 APE9-dihe-na -69.41, 127.44 APE8-dihe-in -73.21, 133.19 APE8-rot-in 299.15 APE67-dihe-in -58.35, -25.3 -102.44, -3.09 APE12-dist-none 999.0 APE11-dist-out 17.365 APE10-dist-out 19.496 APE9-dist-out 10.697 None None None XRAY 1.7 0.177 0.203 A 299 282 16 0 0 11 [[4, 286]] 1.0 4fkv CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3PJ8A 1 298 298.0 404:60299 Type1 Inactive DFGin 10.97 18.772 BLBtrans -107.78, 156.84 69.08, 18.02 -66.97, 133.81 224.59, 103.86 71.6, 7.97 out-out out 14.976 Saltbr-out 16.309 HRD-in -88.87, -56.74 88.08, -24.7 out-out-out SNCooo out-out ActLoopNT-out 5.89 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 133.19 APE9-dihe-na -61.77, 138.14 APE8-dihe-in -79.74, 138.07 APE8-rot-out 182.29 APE67-dihe-in -60.66, -26.06 -106.53, -3.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.99 APE9-dist-out 10.926 None None None XRAY 1.96 0.206 0.273 A 299 287 11 0 0 8 [[4, 286]] 1.0 3pj8 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7VDUA 1 296 298.0 65L:60301 Type1 Inactive DFGin 10.895 18.558 BLBtrans -97.63, 158.27 65.67, 19.39 -67.16, 129.16 225.15, 112.44 87.97, -11.91 out-na out 15.376 Saltbr-na 16.202 HRD-in -85.75, -59.87 79.8, -6.3 na-out-out SNCaoo out-out ActLoopNT-out 5.598 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -69.56, 126.12 APE9-dihe-na -74.42, 120.79 APE8-dihe-in -60.87, 141.08 APE8-rot-out 190.37 APE67-dihe-in -61.73, -29.69 -97.28, -3.08 APE12-dist-out 19.647 APE11-dist-out 17.134 APE10-dist-out 18.718 APE9-dist-out 10.008 None None KCX33 XRAY 1.53 0.18 0.217 A 300 289 7 0 0 0 [[4, 286]] 1.0 7vdu CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8OY2A 2 297 298.0 W5W:301 Type1 Inactive DFGin 10.69 18.806 BLBtrans -110.82, 153.52 63.95, 34.31 -90.46, 119.79 213.0, 119.4 87.33, 8.06 out-out out 15.708 Saltbr-out 13.993 HRD-in -74.33, -64.81 90.27, -45.73 out-out-out SNCooo out-out ActLoopNT-out 6.093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 148.96 APE9-dihe-na -84.43, 138.09 APE8-dihe-in -74.05, 144.09 APE8-rot-out 78.44 APE67-dihe-in -56.35, -26.84 -109.72, 10.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.979 APE9-dist-out 11.025 None None None XRAY 2.618 0.223 0.283 A 300 274 22 0 0 12 [[4, 286]] 1.0 8oy2 CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QQLA 1 298 298.0 X03:299 Type1 Inactive DFGin 10.822 18.466 BLBtrans -115.27, 159.37 71.14, 15.47 -57.16, 133.91 230.1, 104.83 81.07, -8.2 out-out out 15.659 Saltbr-out 16.312 HRD-in -89.63, -55.48 80.09, -13.92 out-out-out SNCooo out-out ActLoopNT-out 5.729 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -69.18, 126.48 APE9-dihe-na -74.42, 125.11 APE8-dihe-in -61.52, 141.32 APE8-rot-out 189.44 APE67-dihe-in -51.23, -30.77 -103.6, -7.33 APE12-dist-out 19.563 APE11-dist-out 17.225 APE10-dist-out 18.668 APE9-dist-out 10.445 None None None XRAY 1.85 0.184 0.224 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qql CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QZFA 1 298 298.0 X66:299 Type1 Inactive DFGin 10.672 17.904 BLBtrans -112.72, 156.45 66.24, 28.61 -69.72, 139.26 232.19, 106.48 75.36, -9.82 out-out out 15.137 Saltbr-out 15.677 HRD-in -86.74, -51.62 76.1, -18.84 out-out-out SNCooo out-out ActLoopNT-out 5.602 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -51.36, 134.1 APE9-dihe-na -84.99, 144.28 APE8-dihe-in -80.53, 139.01 APE8-rot-out 199.26 APE67-dihe-in -50.56, -24.28 -107.41, -5.58 APE12-dist-out 20.439 APE11-dist-out 17.429 APE10-dist-out 18.904 APE9-dist-out 10.757 None None None XRAY 2.0 0.213 0.272 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qzf CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R8LA 1 298 298.0 Z30:423 Type1 Inactive DFGin 10.246 18.2 BLBtrans -134.72, 146.41 77.58, 31.29 -69.92, 121.18 220.55, 119.67 79.34, 10.81 out-out out 15.309 Saltbr-out 15.06 HRD-in -83.18, -54.17 82.54, -21.73 out-out-out SNCooo out-out ActLoopNT-out 5.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -153.15, 131.45 APE9-dihe-na -74.39, 129.55 APE8-dihe-in -79.53, 131.11 APE8-rot-out 184.04 APE67-dihe-in -54.0, -25.33 -106.05, 1.09 APE12-dist-out 20.108 APE11-dist-out 17.829 APE10-dist-out 18.812 APE9-dist-out 10.698 None None None XRAY 1.9 0.217 0.263 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r8l CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R8PA 1 298 298.0 Z46:511 Type1 Inactive DFGin 10.833 18.411 BLBtrans -109.86, 156.59 70.81, 17.77 -61.23, 140.34 230.73, 100.53 77.63, -12.24 out-out out 15.519 Saltbr-out 16.646 HRD-in -89.15, -57.25 84.1, -18.93 out-out-out SNCooo out-out ActLoopNT-out 5.655 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.46, 129.48 APE9-dihe-na -76.63, 129.87 APE8-dihe-in -65.61, 141.91 APE8-rot-out 190.16 APE67-dihe-in -54.29, -28.21 -102.13, -7.0 APE12-dist-out 19.67 APE11-dist-out 17.313 APE10-dist-out 18.759 APE9-dist-out 10.426 None None None XRAY 1.8 0.184 0.218 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r8p CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5MHQA 1 298 298.0 8QT:60301 Type1 Inactive DFGin 10.509 17.958 BLBtrans -105.1, 155.28 71.0, 19.82 -61.49, 132.7 231.75, 105.0 87.38, -12.37 out-na out 15.824 Saltbr-na 14.592 HRD-in -87.81, -60.42 85.21, -14.08 na-out-out SNCaoo out-out ActLoopNT-out 5.852 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.26, 127.09 APE9-dihe-na -74.2, 125.36 APE8-dihe-in -67.97, 142.68 APE8-rot-out 187.95 APE67-dihe-in -66.07, -24.19 -98.86, -1.32 APE12-dist-out 19.512 APE11-dist-out 17.076 APE10-dist-out 18.57 APE9-dist-out 10.452 None None KCX33 XRAY 1.3 0.19 0.226 A 306 289 9 0 0 0 [[4, 286]] 1.0 5mhq CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q4CA 1 298 298.0 HH8:60301 Type1 Inactive DFGin 10.803 18.281 BLBtrans -99.7, 151.19 74.85, 22.65 -57.9, 138.98 239.02, 98.87 71.58, -4.6 out-out out 15.77 Saltbr-out 16.722 HRD-in -88.21, -60.63 80.87, -13.25 out-out-out SNCooo out-out ActLoopNT-out 5.858 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.34, 128.11 APE9-dihe-na -74.88, 130.64 APE8-dihe-in -71.7, 136.54 APE8-rot-out 190.87 APE67-dihe-in -66.44, -25.99 -93.82, -2.36 APE12-dist-out 20.184 APE11-dist-out 17.867 APE10-dist-out 19.012 APE9-dist-out 10.574 None None None XRAY 1.73 0.182 0.223 A 306 291 7 0 0 0 [[4, 286]] 1.0 6q4c CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1GIJA 1 298 298.0 2PU:501 Type1 Inactive DFGin 9.874 16.956 BLBtrans -133.88, 175.66 55.54, 39.88 -99.33, 167.53 215.57, 128.6 35.6, 17.2 out-out out 15.016 Saltbr-out 16.285 HRD-in -89.8, -57.62 82.38, -25.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.42 APE8-dihe-in -72.31, 128.8 APE8-rot-in 296.43 APE67-dihe-in -49.91, -31.83 -105.85, -6.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.223 F82H,L83V,K89T None None XRAY 2.2 0.242 0.286 A 298 273 25 0 0 14 [[4, 286]] 1.0 1gij CMGC_CDK2_HUMAN CMGC 4e-89 305.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2DS1A 1 298 298.0 1CD:501 Type1 Inactive DFGin 10.437 18.3 BLBtrans -116.61, 153.42 67.48, 18.7 -63.18, 129.4 214.48, 110.45 81.76, -11.8 out-out out 14.78 Saltbr-out 14.169 HRD-in -83.84, -50.82 81.37, -22.83 out-out-out SNCooo out-out ActLoopNT-out 5.912 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.66, 129.47 APE9-dihe-na -68.92, 130.97 APE8-dihe-in -66.77, 137.82 APE8-rot-out 181.43 APE67-dihe-in -52.71, -31.71 -102.76, -4.74 APE12-dist-out 19.873 APE11-dist-out 17.505 APE10-dist-out 18.889 APE9-dist-out 10.336 F82H,L83V,K89T None None XRAY 2.0 0.225 0.29 A 298 290 8 0 0 0 [[4, 286]] 1.0 2ds1 CMGC_CDK2_HUMAN CMGC 4e-89 305.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q4DA 1 296 298.0 HHT:301,HHT:302,HHT:303,HHT:304,HHT:305,HHT:306 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 10.559 18.619 BLBtrans -98.54, 149.88 64.48, 29.51 -69.88, 122.17 209.22, 109.84 93.91, -3.77 out-out out 15.528 Saltbr-out 17.097 HRD-in -86.94, -59.39 82.9, -16.25 out-out-out SNCooo out-out ActLoopNT-out 5.57 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.19, 133.26 APE9-dihe-na -69.37, 119.77 APE8-dihe-in -73.96, 108.23 APE8-rot-out 208.44 APE67-dihe-in -63.17, -24.21 -82.02, -5.64 APE12-dist-out 17.75 APE11-dist-out 17.034 APE10-dist-out 19.43 APE9-dist-out 10.791 None None None XRAY 1.07 0.157 0.177 A 306 289 7 0 0 0 [[4, 286]] 1.0 6q4d CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H01A 1 296 298.0 FAL:301,FBL:302 Type1,Type1 Inactive DFGin 10.989 18.669 BLBtrans -111.49, 156.28 70.46, 17.96 -61.52, 133.26 223.32, 110.33 84.91, -12.83 out-na out 15.414 Saltbr-na 15.476 HRD-in -88.66, -59.28 85.0, -16.53 na-out-out SNCaoo out-out ActLoopNT-out 5.564 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.09, 127.84 APE9-dihe-na -75.44, 122.46 APE8-dihe-in -59.62, 143.81 APE8-rot-out 189.61 APE67-dihe-in -49.16, -32.93 -105.49, -7.46 APE12-dist-out 19.636 APE11-dist-out 17.282 APE10-dist-out 18.785 APE9-dist-out 10.152 None None KCX33 XRAY 1.79 0.19 0.219 A 298 287 9 0 0 0 [[4, 286]] 1.0 1h01 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H00A 1 298 298.0 FAP:61300,FCP:61400 Type1,Type1 Inactive DFGin 10.336 18.129 BLBtrans -123.51, 147.17 75.12, 35.25 -78.01, 108.88 223.44, 120.16 83.89, 11.84 out-none out 14.983 Saltbr-none 999.0 HRD-in -86.56, -52.14 80.46, -19.02 none-out-out SNCnoo out-out ActLoopNT-out 6.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -87.75, 124.68 APE9-dihe-na -69.44, 130.06 APE8-dihe-in -74.25, 136.12 APE8-rot-out 186.91 APE67-dihe-in -51.8, -27.34 -105.51, -4.65 APE12-dist-none 999.0 APE11-dist-out 18.077 APE10-dist-out 19.664 APE9-dist-out 10.718 None None None XRAY 1.6 0.208 0.242 A 299 278 20 0 0 10 [[4, 286]] 1.0 1h00 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H07A 1 296 298.0 MFP:60301,MFQ:60302 Type1,Type1 Inactive DFGin 10.287 18.438 BLBtrans -119.42, 153.85 64.96, 30.03 -72.68, 131.31 213.72, 116.73 81.14, -11.07 out-out out 15.176 Saltbr-out 13.566 HRD-in -85.11, -52.28 81.58, -23.62 out-out-out SNCooo out-out ActLoopNT-out 5.936 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.92, 134.14 APE9-dihe-na -79.75, 128.98 APE8-dihe-in -65.26, 139.96 APE8-rot-out 188.54 APE67-dihe-in -47.39, -29.23 -107.81, -9.22 APE12-dist-out 20.048 APE11-dist-out 17.372 APE10-dist-out 18.984 APE9-dist-out 10.507 None None None XRAY 1.85 0.21 0.235 A 299 285 11 0 0 4 [[4, 286]] 1.0 1h07 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1H08A 1 298 298.0 BYP:60299,BWP:60300 Type1,Type1 Inactive DFGin 10.365 17.913 BLBtrans -121.38, 159.43 65.2, 23.42 -67.57, 133.78 220.49, 119.07 72.58, -5.9 out-out out 14.987 Saltbr-out 13.18 HRD-in -85.18, -56.92 88.26, -24.57 out-out-out SNCooo out-out ActLoopNT-out 5.938 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.22, 137.45 APE9-dihe-na -81.14, 125.93 APE8-dihe-in -68.9, 135.86 APE8-rot-out 181.79 APE67-dihe-in -51.97, -29.71 -106.74, -2.02 APE12-dist-out 20.425 APE11-dist-out 17.598 APE10-dist-out 19.42 APE9-dist-out 10.698 None None None XRAY 1.8 0.213 0.242 A 299 283 15 0 0 7 [[4, 286]] 1.0 1h08 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8BYAA 16 296 298.0 No_ligand No_ligand Inactive DFGin 6.962 16.292 None -134.63, 82.03 -161.61, 106.37 -138.09, 26.66 284.26, 105.76 -68.14, -60.43 out-none out 10.062 Saltbr-none 999.0 HRD-out -108.07, -22.97 56.97, -114.32 none-out-out SNCnoo out-out ActLoopNT-out 4.301 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -82.31, 123.39 APE9-dihe-na -125.74, 132.38 APE8-dihe-in -58.14, 137.63 APE8-rot-in 294.3 APE67-dihe-in -69.0, -10.69 -52.48, -40.96 APE12-dist-in 11.325 APE11-dist-out 6.447 APE10-dist-out 9.14 APE9-dist-out 7.129 None TPO159 TPO159 EM 3.38 999.0 999.0 A 298 277 16 0 0 0 [[4, 286]] 1.0 8bya CMGC_CDK2_HUMAN CMGC 6.1e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5UQ1C 1 289 298.0 No_ligand No_ligand Inactive DFGin 6.596 15.653 None -143.1, 67.57 -125.34, 19.31 -94.36, 26.08 301.42, 106.66 -81.71, -31.95 in-in in 9.3 Saltbr-in 3.187 HRD-in -81.67, -52.04 53.83, 40.34 in-in-out SNCiio in-out ActLoopNT-in 2.783 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -139.61, -123.49 APE9-dihe-na -60.35, 138.62 APE8-dihe-in -67.73, 105.22 APE8-rot-out 72.15 APE67-dihe-out -22.19, -25.42 16.7, -96.86 APE12-dist-in 12.299 APE11-dist-in 8.652 APE10-dist-in 7.54 APE9-dist-in 3.945 None None None XRAY 3.201 0.208 0.261 C 301 289 0 0 0 0 [[4, 286]] 1.0 5uq1 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5OO1A 4 298 298.0 9Z2:301 Type1 Inactive DFGin 7.637 16.022 None -121.17, 166.43 66.4, 43.63 -62.57, 999.0 279.44, 78.94 999.0, 999.0 out-out out 15.44 Saltbr-out 10.782 HRD-in -81.97, -55.23 75.2, -10.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 155.58 APE8-dihe-out -76.46, -29.98 APE8-rot-in 295.35 APE67-dihe-in -58.08, -20.66 -40.64, -49.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.166 F80C,C177A None None XRAY 2.0 0.187 0.236 A 303 278 17 0 0 17 [[4, 286]] 1.0 5oo1 CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PYEA 1 298 298.0 PM1:700 Type1 Inactive DFGin 8.22 15.465 None -124.58, 165.75 48.02, 64.22 -62.08, 999.0 279.52, 59.87 999.0, 999.0 out-out out 15.012 Saltbr-out 12.46 HRD-in -83.61, -50.44 78.62, -18.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 167.42 APE9-dihe-na -72.88, 127.15 APE8-dihe-in -72.71, 140.05 APE8-rot-out 63.06 APE67-dihe-in -52.66, -26.74 -106.34, -2.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.547 None None None XRAY 2.0 0.239 0.252 A 298 266 32 0 0 16 [[4, 286]] 1.0 1pye CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2W05A 1 298 298.0 FRT:1299 Type1 Inactive DFGin 8.905 15.929 None -128.23, 165.06 62.24, 43.64 -62.21, -101.33 274.85, 83.58 96.54, -134.12 out-out out 15.011 Saltbr-out 13.58 HRD-in -86.31, -48.92 76.7, -14.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -141.95, 27.61 APE9-dihe-na -84.15, 133.89 APE8-dihe-in -68.78, 136.67 APE8-rot-out 189.07 APE67-dihe-in -51.29, -28.78 -104.64, -0.82 APE12-dist-none 999.0 APE11-dist-out 16.582 APE10-dist-out 19.183 APE9-dist-out 10.372 None None None XRAY 1.9 0.23 0.293 A 298 276 22 0 0 13 [[4, 286]] 1.0 2w05 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5D1JA 1 298 298.0 56H:4000 Type1 Inactive DFGin 8.637 15.284 None -137.97, 170.56 53.49, 55.77 -71.24, 999.0 283.47, 73.89 999.0, 999.0 out-none out 14.929 Saltbr-none 999.0 HRD-in -80.57, -53.12 79.22, -17.55 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.54 APE8-dihe-in -86.85, 121.49 APE8-rot-in 299.19 APE67-dihe-in -55.62, -31.72 -100.82, -4.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.155 None None None XRAY 1.8 0.203 0.232 A 298 265 33 0 0 17 [[4, 286]] 1.0 5d1j CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QL8A 1 298 298.0 X01:300 Type1 Inactive DFGin 9.132 15.435 None -122.25, 168.91 72.46, -145.11 131.38, -129.83 255.48, 110.66 -62.05, 95.07 out-out out 15.566 Saltbr-out 15.206 HRD-in -84.45, -59.47 81.38, -15.8 out-out-out SNCooo out-out ActLoopNT-out 6.609 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -83.89, 109.54 APE9-dihe-na -59.93, 129.67 APE8-dihe-in -81.59, 123.65 APE8-rot-in 299.9 APE67-dihe-in -51.56, -28.22 -100.19, -8.52 APE12-dist-out 19.719 APE11-dist-out 16.758 APE10-dist-out 19.035 APE9-dist-out 11.061 None None None XRAY 1.9 0.202 0.238 A 306 294 4 0 0 0 [[4, 286]] 1.0 3ql8 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QWJA 1 298 298.0 X6A:483 Type1 Inactive DFGin 10.828 18.605 None -114.29, 146.98 65.6, 42.02 -53.47, -101.22 231.88, 79.31 -68.75, 30.41 out-out out 15.345 Saltbr-out 12.427 HRD-in -84.5, -56.26 82.9, -19.63 out-out-out SNCooo out-out ActLoopNT-out 6.131 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.81, 125.39 APE9-dihe-na -71.61, 131.09 APE8-dihe-in -83.22, 123.55 APE8-rot-in 295.87 APE67-dihe-in -56.8, -26.34 -103.15, 1.31 APE12-dist-out 20.289 APE11-dist-out 17.631 APE10-dist-out 19.675 APE9-dist-out 10.989 None None None XRAY 1.75 0.206 0.229 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qwj CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QX4A 1 298 298.0 X4B:454 Type1 Inactive DFGin 10.988 18.339 None -117.48, 147.66 64.55, 41.52 -55.77, -90.1 235.01, 81.0 -76.36, 28.96 out-out out 15.635 Saltbr-out 14.18 HRD-in -81.9, -60.6 86.28, -21.21 out-out-out SNCooo out-out ActLoopNT-out 5.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -65.97, 121.02 APE9-dihe-na -66.55, 127.88 APE8-dihe-in -80.02, 120.64 APE8-rot-in 297.75 APE67-dihe-in -54.34, -28.48 -100.67, -3.24 APE12-dist-out 20.085 APE11-dist-out 17.422 APE10-dist-out 19.69 APE9-dist-out 10.935 None None None XRAY 1.92 0.205 0.238 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qx4 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R9HA 1 298 298.0 Z67:606 Type1 Inactive DFGin 8.303 15.287 None -120.0, 168.79 77.09, -84.14 71.52, 122.55 279.89, 89.71 -46.26, -69.21 out-out out 14.776 Saltbr-out 14.153 HRD-in -82.5, -51.28 73.26, -15.2 out-out-out SNCooo out-out ActLoopNT-out 7.868 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -57.18, 102.97 APE9-dihe-na -66.25, 137.88 APE8-dihe-in -87.27, 136.09 APE8-rot-in 301.21 APE67-dihe-in -49.8, -36.88 -111.15, -2.68 APE12-dist-out 20.724 APE11-dist-out 17.674 APE10-dist-out 20.037 APE9-dist-out 11.097 None None None XRAY 2.1 0.214 0.259 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r9h CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RK5A 1 298 298.0 07Z:436 Type1 Inactive DFGin 8.254 15.151 None -135.71, 162.54 80.12, -66.74 62.53, 4.94 282.99, 77.39 53.28, -132.52 out-out out 14.736 Saltbr-out 13.125 HRD-in -80.28, -56.17 79.56, -17.53 out-out-out SNCooo out-out ActLoopNT-out 7.575 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.64, 108.95 APE9-dihe-na -69.16, 141.75 APE8-dihe-in -86.76, 130.53 APE8-rot-in 282.62 APE67-dihe-in -51.32, -32.2 -101.03, -6.74 APE12-dist-out 20.054 APE11-dist-out 16.563 APE10-dist-out 18.845 APE9-dist-out 11.032 None None None XRAY 2.0 0.206 0.238 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rk5 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RK7A 1 298 298.0 08Z:467 Type1 Inactive DFGin 8.229 15.161 None -129.7, 167.95 74.53, -59.76 60.9, 15.2 281.75, 75.35 53.86, -103.4 out-out out 14.887 Saltbr-out 15.025 HRD-in -81.84, -56.89 82.92, -16.54 out-out-out SNCooo out-out ActLoopNT-out 7.676 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.0, 97.8 APE9-dihe-na -61.23, 134.9 APE8-dihe-in -84.34, 129.91 APE8-rot-in 290.25 APE67-dihe-in -55.99, -28.83 -103.41, -0.58 APE12-dist-out 20.856 APE11-dist-out 17.133 APE10-dist-out 19.578 APE9-dist-out 11.061 None None None XRAY 1.8 0.206 0.224 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rk7 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RKBA 1 298 298.0 12Z:457 Type1 Inactive DFGin 7.962 15.344 None -136.32, 169.7 52.72, 57.61 -64.16, -102.19 278.37, 71.06 -78.55, 125.67 out-out out 15.318 Saltbr-out 13.622 HRD-in -80.71, -50.21 81.81, -22.27 out-out-out SNCooo out-out ActLoopNT-out 8.929 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.87, 109.93 APE9-dihe-na -69.0, 132.49 APE8-dihe-in -79.46, 128.25 APE8-rot-out 184.86 APE67-dihe-in -52.12, -32.05 -102.56, -4.29 APE12-dist-out 17.061 APE11-dist-out 14.007 APE10-dist-out 16.788 APE9-dist-out 11.04 None None None XRAY 2.0 0.207 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rkb CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RM6A 1 298 298.0 18Z:478 Type1 Inactive DFGin 8.595 15.48 None -127.31, 175.21 70.31, -63.24 64.35, 17.5 284.18, 82.41 61.96, 14.33 out-out out 15.713 Saltbr-out 17.431 HRD-in -88.48, -59.71 83.31, -19.73 out-out-out SNCooo out-out ActLoopNT-out 6.257 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.49, 112.67 APE9-dihe-na -67.84, 129.1 APE8-dihe-in -77.92, 125.13 APE8-rot-out 171.09 APE67-dihe-in -52.76, -26.7 -104.02, -2.64 APE12-dist-out 19.203 APE11-dist-out 15.598 APE10-dist-out 18.772 APE9-dist-out 11.131 None None None XRAY 1.6 0.22 0.241 A 306 293 5 0 0 0 [[4, 286]] 1.0 3rm6 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3S0OA 1 298 298.0 50Z:446 Type1 Inactive DFGin 8.504 14.987 None -136.17, 174.47 56.71, 50.73 -53.6, 999.0 285.42, 58.7 999.0, 999.0 out-out out 15.686 Saltbr-out 14.141 HRD-in -92.71, -50.76 76.76, -17.93 out-out-out SNCooo out-out ActLoopNT-out 5.722 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -76.57, 93.08 APE9-dihe-na -52.85, 136.54 APE8-dihe-in -88.54, 130.77 APE8-rot-out 176.51 APE67-dihe-in -49.84, -33.28 -101.8, -5.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.035 None None None XRAY 2.0 0.213 0.271 A 306 293 5 0 0 2 [[4, 286]] 1.0 3s0o CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8RU8A 1 298 298.0 I74:301 Type1 Inactive DFGin 8.492 15.372 None -138.93, 165.19 64.8, 51.39 -61.53, 999.0 281.7, 71.9 999.0, 999.0 out-out out 15.21 Saltbr-out 14.407 HRD-in -79.32, -55.83 85.03, -22.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -92.95, 127.12 APE9-dihe-na -56.69, 130.27 APE8-dihe-in -92.47, 122.83 APE8-rot-in 301.98 APE67-dihe-in -63.56, -25.08 -104.73, 1.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.257 I10L,T14Q,V64I,K88E,K89V,D92K,Q131N None None XRAY 1.51 0.205 0.241 A 306 275 23 0 0 14 [[4, 286]] 1.0 8ru8 CMGC_CDK2_HUMAN CMGC 1.5e-88 303.3 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3EZRA 1 298 298.0 EZR:300,EZR:301 Type1,Allosteric Inactive DFGin 10.139 18.131 None -127.03, 166.36 56.16, 26.16 -69.94, 999.0 212.22, 111.94 999.0, 999.0 out-out out 14.98 Saltbr-out 15.44 HRD-in -76.59, -53.67 86.14, -23.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.39 APE8-rot-out 187.95 APE67-dihe-in -60.61, -23.99 -102.93, -2.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.208 0.243 A 300 273 25 0 0 18 [[4, 286]] 1.0 3ezr CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5A14A 1 296 298.0 LQ5:61297,LQ5:61298 Type2,Allosteric Inactive DFGout 16.189 8.578 None -142.75, 171.68 -138.74, 99.61 -93.91, 17.83 195.09, 58.2 -60.92, 125.74 in-in in 8.372 Saltbr-in 2.841 HRD-in -65.77, -62.64 84.1, -18.65 in-out-out SNCioo out-out ActLoopNT-out 15.046 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 102.43 APE8-dihe-in -81.63, 144.13 APE8-rot-out 74.04 APE67-dihe-in -61.27, -29.59 -107.38, -0.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.171 None None None XRAY 2.0 0.197 0.24 A 299 284 12 0 0 10 [[4, 286]] 1.0 5a14 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q3FA 1 298 298.0 HEW:60301 Allosteric Inactive None 11.361 18.485 None -100.23, 146.03 76.96, 22.05 -56.57, 140.57 248.16, 89.95 83.91, -13.62 out-out out 15.364 Saltbr-out 17.74 HRD-in -87.95, -62.63 79.68, -15.73 out-out-out SNCooo out-out ActLoopNT-out 5.734 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.97, 126.52 APE9-dihe-na -73.61, 124.69 APE8-dihe-in -63.01, 140.77 APE8-rot-out 188.63 APE67-dihe-in -61.19, -27.7 -97.02, -5.86 APE12-dist-out 20.244 APE11-dist-out 17.605 APE10-dist-out 18.911 APE9-dist-out 10.278 None None OCS177 XRAY 1.18 0.163 0.189 A 306 289 9 0 0 0 [[4, 286]] 1.0 6q3f CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q49A 1 298 298.0 HGQ:402 Allosteric Inactive None 11.685 18.287 None -102.71, 149.23 81.53, 18.71 -53.72, 141.75 260.6, 87.13 82.9, -13.25 out-out out 15.606 Saltbr-out 17.027 HRD-in -92.34, -62.66 83.92, -15.17 out-out-out SNCooo out-out ActLoopNT-out 5.883 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -56.92, 142.28 APE9-dihe-na -102.94, 76.38 APE8-dihe-in -27.85, 126.48 APE8-rot-in 312.85 APE67-dihe-in -63.54, -23.09 -100.36, -3.16 APE12-dist-none 999.0 APE11-dist-out 18.124 APE10-dist-out 19.328 APE9-dist-out 10.711 None None None XRAY 1.0 0.176 0.197 A 306 287 11 0 0 5 [[4, 286]] 1.0 6q49 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1BUHA 1 294 298.0 No_ligand No_ligand Inactive None 11.466 18.426 None -112.91, 155.37 66.6, 26.15 -71.37, 139.52 251.03, 90.58 74.51, -2.49 out-out out 16.028 Saltbr-out 16.53 HRD-in -106.58, -47.16 68.81, -29.93 out-out-out SNCooo out-out ActLoopNT-out 6.184 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -90.4, 120.25 APE9-dihe-na -61.56, 166.63 APE8-dihe-in -97.12, 112.03 APE8-rot-in 292.08 APE67-dihe-in -38.64, -29.38 -79.29, -29.19 APE12-dist-out 19.831 APE11-dist-out 18.055 APE10-dist-out 19.892 APE9-dist-out 11.06 None None None XRAY 2.6 0.19 0.25 A 298 287 7 0 0 0 [[4, 286]] 1.0 1buh CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3PXRA 1 298 298.0 No_ligand No_ligand Inactive None 11.449 18.212 None -108.67, 148.57 74.26, 20.64 -60.7, 145.93 248.03, 94.08 71.76, -11.33 out-out out 15.618 Saltbr-out 16.06 HRD-in -87.7, -57.28 81.45, -23.23 out-out-out SNCooo out-out ActLoopNT-out 5.643 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -69.38, 108.05 APE9-dihe-na -62.96, 126.43 APE8-dihe-in -77.47, 127.15 APE8-rot-in 292.83 APE67-dihe-in -51.66, -30.8 -103.08, -6.14 APE12-dist-out 20.448 APE11-dist-out 16.274 APE10-dist-out 19.528 APE9-dist-out 10.817 None None None XRAY 2.0 0.201 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3pxr CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q4IA 1 298 298.0 HGK:302 Type1 Inactive None 12.098 18.408 None -99.36, 137.19 84.12, 26.37 -69.75, 135.57 246.02, 97.85 90.07, -16.34 out-out out 15.636 Saltbr-out 17.437 HRD-in -93.72, -60.37 85.29, -19.56 out-out-out SNCooo out-out ActLoopNT-out 5.843 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -72.57, 111.89 APE9-dihe-na -68.89, 135.45 APE8-dihe-in -83.49, 131.66 APE8-rot-in 320.5 APE67-dihe-in -63.59, -24.06 -101.41, -3.71 APE12-dist-out 18.994 APE11-dist-out 16.989 APE10-dist-out 19.986 APE9-dist-out 11.167 None None None XRAY 1.11 0.166 0.192 A 306 288 10 0 0 3 [[4, 286]] 1.0 6q4i CMGC_CDK2_HUMAN CMGC 1.5e-89 306.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5OSMA 1 296 298.0 AEQ:60301 Type1 Inactive None 11.127 18.074 None -109.86, 154.17 73.12, 16.86 -53.0, 141.72 257.69, 89.04 82.05, -16.7 out-out out 15.318 Saltbr-out 14.286 HRD-in -90.86, -56.33 70.3, -3.17 out-out-out SNCooo out-out ActLoopNT-out 5.659 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.75, 128.04 APE9-dihe-na -79.09, 125.46 APE8-dihe-in -62.78, 142.77 APE8-rot-out 191.22 APE67-dihe-in -64.68, -24.31 -97.3, -5.26 APE12-dist-out 20.001 APE11-dist-out 17.438 APE10-dist-out 18.797 APE9-dist-out 10.314 F80C,C177A None None XRAY 1.77 0.164 0.206 A 303 288 8 0 0 0 [[4, 286]] 1.0 5osm CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
8UV0A 2 298 298.0 XKU:301 Type1 Inactive None 11.617 18.625 None -105.02, 146.29 77.57, 16.65 -61.47, 139.79 252.4, 92.71 79.92, -11.38 out-none out 15.124 Saltbr-none 999.0 HRD-in -86.89, -59.38 84.83, -19.27 none-out-out SNCnoo out-out ActLoopNT-out 5.809 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.27 APE8-dihe-in -78.16, 130.23 APE8-rot-out 191.99 APE67-dihe-in -66.33, -22.53 -104.08, -2.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.685 None None None XRAY 1.55 0.158 0.203 A 297 279 18 0 0 10 [[4, 286]] 1.0 8uv0 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q4GA 1 298 298.0 HJK:301 Type1 Inactive None 12.141 18.392 None -101.91, 150.38 79.79, 21.42 -70.25, 129.25 248.2, 99.54 94.46, -14.8 out-out out 15.566 Saltbr-out 16.264 HRD-in -91.6, -63.58 84.13, -16.52 out-out-out SNCooo out-out ActLoopNT-out 5.863 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 126.31 APE8-dihe-in -81.05, 101.62 APE8-rot-out 209.32 APE67-dihe-in -64.62, -22.35 -81.81, -4.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.325 None None None XRAY 0.98 0.191 0.211 A 306 282 16 0 0 10 [[4, 286]] 1.0 6q4g CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
1PXOA 1 298 298.0 CK7:500 Type1 Inactive None 11.567 18.282 None -110.76, 143.93 77.57, 24.97 -67.83, 134.31 244.11, 100.76 81.87, -11.45 out-out out 14.838 Saltbr-out 18.679 HRD-in -91.02, -53.1 76.42, -22.91 out-out-out SNCooo out-out ActLoopNT-out 5.722 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -132.43, 155.5 APE9-dihe-na -56.3, 174.32 APE8-dihe-in -103.47, 109.63 APE8-rot-out 181.49 APE67-dihe-in -54.18, -30.19 -68.46, -22.69 APE12-dist-out 20.782 APE11-dist-out 16.708 APE10-dist-out 16.669 APE9-dist-out 8.527 None None None XRAY 1.96 0.22 0.235 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pxo CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2C6OA 1 296 298.0 4SP:1297 Type1 Inactive None 11.114 17.988 None -115.56, 145.07 66.98, 16.14 -33.59, 128.29 259.93, 90.05 77.49, -4.49 out-out out 14.321 Saltbr-out 16.413 HRD-in -83.83, -61.4 84.51, -12.2 out-out-out SNCooo out-out ActLoopNT-out 5.874 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.26, 136.47 APE9-dihe-na -73.22, 134.2 APE8-dihe-in -68.16, 148.17 APE8-rot-out 36.23 APE67-dihe-in -69.25, -25.79 -97.86, -1.88 APE12-dist-out 20.031 APE11-dist-out 17.633 APE10-dist-out 18.906 APE9-dist-out 10.377 None None None XRAY 2.1 0.235 0.288 A 298 290 6 0 0 0 [[4, 286]] 1.0 2c6o CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2UZOA 1 296 298.0 C62:1297 Type1 Inactive None 11.674 18.358 None -103.85, 147.99 79.37, 16.08 -56.3, 131.44 252.32, 87.14 85.48, -16.56 out-out out 15.287 Saltbr-out 14.642 HRD-in -79.48, -63.51 86.69, -26.67 out-out-out SNCooo out-out ActLoopNT-out 5.78 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -48.56, 93.61 APE9-dihe-na -64.42, -179.03 APE8-dihe-in -107.54, 95.92 APE8-rot-in 302.08 APE67-dihe-in -62.89, -28.35 -73.92, -8.85 APE12-dist-out 20.518 APE11-dist-out 17.709 APE10-dist-out 20.231 APE9-dist-out 10.715 None None None XRAY 2.3 0.215 0.291 A 298 290 6 0 0 0 [[4, 286]] 1.0 2uzo CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4D1XA 3 298 298.0 ESJ:1299 Type1 Inactive None 11.491 18.242 None -113.21, 150.67 79.12, 23.97 -66.73, 134.11 245.75, 106.66 76.37, -5.48 out-out out 15.281 Saltbr-out 16.773 HRD-in -98.94, -51.15 72.95, -12.44 out-out-none SNCoon out-none ActLoopNT-out 5.901 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.04 APE8-rot-in 301.03 APE67-dihe-in -57.19, -29.17 -104.26, -4.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.196 0.238 A 298 274 22 0 0 11 [[4, 286]] 1.0 4d1x CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4KD1A 1 298 298.0 1QK:302 Type1 Inactive None 11.432 18.492 None -103.77, 151.97 77.61, 19.25 -58.19, 138.93 250.92, 90.26 83.97, -15.13 out-out out 16.188 Saltbr-out 15.447 HRD-in -91.06, -59.16 81.9, -15.37 out-out-out SNCooo out-out ActLoopNT-out 5.795 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.97, 126.64 APE9-dihe-na -71.76, 135.1 APE8-dihe-in -76.23, 141.92 APE8-rot-out 185.92 APE67-dihe-in -62.18, -24.46 -100.06, -1.99 APE12-dist-out 20.481 APE11-dist-out 17.738 APE10-dist-out 19.152 APE9-dist-out 10.541 None None None XRAY 1.7 0.194 0.232 A 298 298 0 0 0 0 [[4, 286]] 1.0 4kd1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5IEXA 1 298 298.0 6AF:1001 Type1 Inactive None 11.106 18.344 None -105.6, 149.53 71.37, 22.65 -61.85, 135.15 236.62, 103.3 74.49, -10.58 out-out out 15.176 Saltbr-out 15.226 HRD-in -80.72, -65.3 84.99, -26.41 out-out-out SNCooo out-out ActLoopNT-out 5.802 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 111.81 APE8-dihe-in -112.57, 117.73 APE8-rot-in 277.98 APE67-dihe-in -67.92, -29.52 -99.02, -2.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.275 None None None XRAY 2.03 0.206 0.254 A 298 285 13 0 0 8 [[4, 286]] 1.0 5iex CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
5JQ5A 3 298 298.0 I74:302 Type1 Inactive None 11.036 18.59 None -98.25, 154.49 69.12, 17.56 -59.33, 137.78 236.33, 97.04 85.8, -18.24 out-out out 15.293 Saltbr-out 14.692 HRD-in -87.26, -60.66 80.63, -8.99 out-out-out SNCooo out-out ActLoopNT-out 5.642 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.18, 129.81 APE9-dihe-na -70.39, 120.4 APE8-dihe-in -59.82, 139.82 APE8-rot-out 191.58 APE67-dihe-in -61.81, -24.27 -96.08, -3.96 APE12-dist-out 19.621 APE11-dist-out 17.053 APE10-dist-out 18.629 APE9-dist-out 10.149 None None None XRAY 1.94 0.184 0.241 A 298 287 9 0 0 0 [[4, 286]] 1.0 5jq5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9FR2A 2 298 298.0 A1IE9:60301 Type1 Inactive None 11.37 18.225 None -103.47, 145.86 75.07, 24.54 -56.91, 141.61 253.67, 81.9 80.39, -12.16 out-out out 15.142 Saltbr-out 16.52 HRD-in -86.51, -58.7 78.24, -12.72 out-out-out SNCooo out-out ActLoopNT-out 5.738 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 138.37 APE9-dihe-na -76.24, 137.14 APE8-dihe-in -76.41, 139.85 APE8-rot-out 191.03 APE67-dihe-in -65.58, -24.55 -103.01, -3.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.146 APE9-dist-out 10.5 None None None XRAY 1.6 0.188 0.223 A 299 280 17 0 0 9 [[4, 286]] 1.0 9fr2 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3LA 1 298 298.0 SCW:60501 Type1 Inactive None 11.246 18.353 None -114.1, 142.0 80.75, 16.79 -62.6, 137.12 236.35, 103.25 77.55, -11.17 out-out out 14.942 Saltbr-out 14.238 HRD-in -87.21, -57.16 83.97, -21.0 out-out-none SNCoon out-none ActLoopNT-out 5.715 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -74.73, 130.61 APE8-rot-in 281.88 APE67-dihe-in -55.71, -27.13 -104.47, -1.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None CSD177 XRAY 1.65 0.195 0.226 A 299 278 20 0 0 13 [[4, 286]] 1.0 2r3l CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
2R3RA 1 298 298.0 6SC:60501 Type1 Inactive None 11.191 18.352 None -106.75, 151.66 74.43, 19.48 -59.69, 136.1 237.56, 102.06 82.51, -14.57 out-out out 15.144 Saltbr-out 15.801 HRD-in -90.58, -56.8 78.13, -12.52 out-out-out SNCooo out-out ActLoopNT-out 5.734 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.03, 131.85 APE9-dihe-na -78.03, 123.76 APE8-dihe-in -61.28, 139.29 APE8-rot-out 191.45 APE67-dihe-in -54.67, -29.47 -98.71, -6.16 APE12-dist-out 20.056 APE11-dist-out 17.505 APE10-dist-out 18.862 APE9-dist-out 10.181 None None None XRAY 1.47 0.188 0.211 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3r CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3IGGA 1 298 298.0 EFQ:60999 Type1 Inactive None 11.372 18.317 None -105.84, 154.3 67.56, 24.15 -61.58, 141.43 251.07, 85.51 77.86, -9.43 out-out out 15.186 Saltbr-out 14.289 HRD-in -86.14, -57.51 81.55, -17.84 out-out-out SNCooo out-out ActLoopNT-out 5.712 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.13, 117.94 APE9-dihe-na -63.08, 134.91 APE8-dihe-in -69.96, 139.07 APE8-rot-out 188.39 APE67-dihe-in -58.19, -28.22 -106.27, -3.06 APE12-dist-out 20.463 APE11-dist-out 17.592 APE10-dist-out 19.328 APE9-dist-out 10.535 None None None XRAY 1.8 0.209 0.257 A 299 290 8 0 0 0 [[4, 286]] 1.0 3igg CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3SW4A 1 298 298.0 18K:60299 Type1 Inactive None 11.515 17.956 None -115.31, 149.88 75.83, 22.3 -62.2, 138.18 254.06, 93.83 74.54, -5.64 out-out out 15.162 Saltbr-out 16.039 HRD-in -87.88, -56.91 79.23, -12.91 out-out-out SNCooo out-out ActLoopNT-out 5.897 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 117.56 APE8-dihe-in -88.23, 129.35 APE8-rot-out 189.49 APE67-dihe-in -57.9, -26.2 -102.28, -2.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.96 None None None XRAY 1.7 0.185 0.208 A 299 280 18 0 0 10 [[4, 286]] 1.0 3sw4 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKQA 1 298 298.0 42K:60301 Type1 Inactive None 11.66 18.286 None -107.48, 146.45 78.71, 22.13 -63.74, 140.69 251.54, 94.03 78.47, -10.57 out-out out 15.262 Saltbr-out 16.202 HRD-in -91.18, -60.25 83.19, -19.11 out-out-out SNCooo out-out ActLoopNT-out 5.763 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 108.27 APE8-dihe-in -82.63, 126.27 APE8-rot-in 306.59 APE67-dihe-in -57.36, -27.98 -101.58, -3.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.031 None None None XRAY 1.75 0.177 0.195 A 299 283 15 0 0 9 [[4, 286]] 1.0 4fkq CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
4FKRA 1 298 298.0 45K:60301 Type1 Inactive None 11.549 18.516 None -111.74, 136.12 81.89, 36.01 -71.33, 130.78 250.71, 96.33 87.17, -17.31 out-out out 15.279 Saltbr-out 15.596 HRD-in -82.95, -56.41 79.68, -19.26 out-out-out SNCooo out-out ActLoopNT-out 5.992 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 124.01 APE9-dihe-na -64.18, 132.07 APE8-dihe-in -80.68, 132.68 APE8-rot-out 185.99 APE67-dihe-in -57.69, -26.44 -102.01, -3.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.781 APE9-dist-out 10.81 None None None XRAY 1.9 0.176 0.213 A 299 282 16 0 0 9 [[4, 286]] 1.0 4fkr CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QQFA 1 298 298.0 X07:543 Type1 Inactive None 11.451 18.483 None -112.65, 145.94 75.36, 24.29 -63.92, 139.11 248.21, 85.21 74.3, -5.06 out-out out 15.248 Saltbr-out 16.904 HRD-in -89.36, -58.1 83.53, -19.98 out-out-out SNCooo out-out ActLoopNT-out 5.733 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -60.07, 115.72 APE9-dihe-na -63.98, 132.41 APE8-dihe-in -83.8, 128.69 APE8-rot-in 304.89 APE67-dihe-in -56.5, -26.93 -103.69, -1.4 APE12-dist-out 21.167 APE11-dist-out 16.977 APE10-dist-out 19.653 APE9-dist-out 10.877 None None None XRAY 1.75 0.198 0.234 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qqf CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QQJA 1 298 298.0 X11:300 Type1 Inactive None 11.296 17.14 None -118.58, 158.94 68.7, 32.83 -72.06, 149.44 252.09, 99.03 65.67, 11.61 out-out out 15.494 Saltbr-out 15.185 HRD-in -89.76, -64.75 84.08, -16.02 out-out-out SNCooo out-out ActLoopNT-out 5.723 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -51.86, 104.06 APE9-dihe-na -56.13, 139.44 APE8-dihe-in -84.97, 113.86 APE8-rot-in 306.15 APE67-dihe-in -54.47, -25.16 -98.88, -9.11 APE12-dist-out 20.988 APE11-dist-out 17.191 APE10-dist-out 20.094 APE9-dist-out 11.233 None None None XRAY 1.7 0.206 0.237 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qqj CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QTSA 1 298 298.0 X46:299 Type1 Inactive None 11.782 18.126 None -114.89, 146.71 82.32, 20.63 -64.09, 138.52 252.86, 94.41 77.98, -5.5 out-out out 15.441 Saltbr-out 15.983 HRD-in -94.26, -58.23 79.96, -10.62 out-out-out SNCooo out-out ActLoopNT-out 5.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 116.66 APE9-dihe-na -67.98, 136.18 APE8-dihe-in -82.21, 129.95 APE8-rot-in 311.7 APE67-dihe-in -51.26, -29.33 -105.51, -4.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.9 APE9-dist-out 11.042 None None None XRAY 1.9 0.214 0.231 A 306 282 16 0 0 8 [[4, 286]] 1.0 3qts CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QX2A 1 298 298.0 X63:300 Type1 Inactive None 11.339 18.8 None -109.52, 148.71 71.85, 23.51 -63.31, 136.62 243.05, 92.47 79.87, -9.86 out-out out 15.512 Saltbr-out 16.755 HRD-in -88.64, -58.7 83.57, -18.8 out-out-out SNCooo out-out ActLoopNT-out 5.873 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -80.45, 130.14 APE9-dihe-na -66.55, 130.29 APE8-dihe-in -81.03, 134.06 APE8-rot-in 304.55 APE67-dihe-in -57.44, -26.49 -104.17, -0.27 APE12-dist-out 20.535 APE11-dist-out 17.588 APE10-dist-out 19.312 APE9-dist-out 10.833 None None None XRAY 1.75 0.203 0.228 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qx2 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QXOA 1 298 298.0 X65:668 Type1 Inactive None 11.574 18.493 None -110.12, 147.39 74.3, 21.4 -62.68, 143.03 247.92, 93.66 75.65, -10.29 out-out out 15.232 Saltbr-out 17.414 HRD-in -89.82, -59.23 81.49, -17.74 out-out-out SNCooo out-out ActLoopNT-out 5.717 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -55.35, 115.79 APE9-dihe-na -65.26, 130.77 APE8-dihe-in -78.05, 132.32 APE8-rot-out 188.29 APE67-dihe-in -54.53, -26.63 -103.75, -2.8 APE12-dist-out 21.021 APE11-dist-out 17.125 APE10-dist-out 19.546 APE9-dist-out 10.758 None None None XRAY 1.75 0.2 0.233 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qxo CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QZGA 1 298 298.0 X67:471 Type1 Inactive None 11.166 17.869 None -119.24, 148.14 78.56, 29.6 -71.06, 140.3 240.31, 103.03 70.92, -7.43 out-out out 15.26 Saltbr-out 13.648 HRD-in -89.25, -59.92 83.69, -18.01 out-out-out SNCooo out-out ActLoopNT-out 5.707 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.58, 101.29 APE9-dihe-na -63.57, 138.04 APE8-dihe-in -85.08, 127.05 APE8-rot-out 179.07 APE67-dihe-in -56.84, -25.22 -100.01, -3.06 APE12-dist-out 21.43 APE11-dist-out 17.477 APE10-dist-out 20.174 APE9-dist-out 11.134 None None None XRAY 1.75 0.202 0.226 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qzg CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QZHA 1 298 298.0 X69:839 Type1 Inactive None 11.47 18.511 None -109.96, 147.01 77.55, 20.64 -62.91, 134.83 250.02, 87.84 79.57, -11.69 out-out out 15.274 Saltbr-out 17.082 HRD-in -86.11, -57.23 83.13, -19.43 out-out-out SNCooo out-out ActLoopNT-out 5.717 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -79.24, 110.72 APE9-dihe-na -62.06, 126.03 APE8-dihe-in -79.43, 134.37 APE8-rot-out 78.44 APE67-dihe-in -50.01, -33.55 -102.85, -1.51 APE12-dist-out 20.944 APE11-dist-out 17.133 APE10-dist-out 19.797 APE9-dist-out 10.94 None None None XRAY 1.95 0.2 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qzh CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3QZIA 1 298 298.0 X72:512 Type1 Inactive None 11.241 18.712 None -119.9, 143.48 80.19, 23.62 -68.59, 125.89 238.63, 103.46 88.77, -15.06 out-out out 15.868 Saltbr-out 16.079 HRD-in -87.48, -54.88 80.99, -18.97 out-out-out SNCooo out-out ActLoopNT-out 5.8 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -79.37, 108.03 APE9-dihe-na -59.79, 125.48 APE8-dihe-in -80.49, 121.74 APE8-rot-in 303.88 APE67-dihe-in -54.55, -27.28 -100.59, -2.07 APE12-dist-out 20.896 APE11-dist-out 17.084 APE10-dist-out 20.119 APE9-dist-out 11.169 None None None XRAY 1.75 0.207 0.236 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qzi CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R1QA 1 298 298.0 X75:616 Type1 Inactive None 11.368 18.457 None -115.65, 139.42 82.38, 27.94 -68.27, 134.48 251.33, 83.78 76.9, -4.37 out-out out 15.934 Saltbr-out 16.912 HRD-in -86.83, -58.27 82.98, -19.66 out-out-out SNCooo out-out ActLoopNT-out 5.72 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -65.16, 109.15 APE9-dihe-na -63.73, 128.5 APE8-dihe-in -80.12, 122.89 APE8-rot-in 299.78 APE67-dihe-in -55.47, -28.14 -102.73, -0.85 APE12-dist-out 21.35 APE11-dist-out 16.855 APE10-dist-out 20.064 APE9-dist-out 11.102 None None None XRAY 1.85 0.207 0.237 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r1q CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R1SA 1 298 298.0 X73:647 Type1 Inactive None 11.563 18.462 None -112.29, 145.39 77.72, 20.9 -61.31, 140.86 249.71, 86.98 70.88, -5.99 out-out out 15.609 Saltbr-out 16.564 HRD-in -91.22, -58.91 83.77, -21.39 out-out-out SNCooo out-out ActLoopNT-out 5.777 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.87, 116.85 APE9-dihe-na -63.44, 131.28 APE8-dihe-in -83.21, 125.36 APE8-rot-in 299.44 APE67-dihe-in -52.01, -29.26 -101.45, -2.84 APE12-dist-out 21.103 APE11-dist-out 17.495 APE10-dist-out 19.908 APE9-dist-out 10.979 None None None XRAY 1.8 0.196 0.224 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r1s CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R1YA 1 298 298.0 X76:488 Type1 Inactive None 11.627 18.603 None -109.35, 144.39 74.97, 25.22 -61.66, 142.02 249.79, 91.38 72.48, -3.61 out-out out 15.569 Saltbr-out 15.939 HRD-in -90.13, -57.08 83.2, -20.8 out-out-out SNCooo out-out ActLoopNT-out 5.847 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -83.02, 119.47 APE9-dihe-na -71.17, 135.18 APE8-dihe-in -73.39, 137.33 APE8-rot-out 192.27 APE67-dihe-in -53.93, -27.04 -107.87, -3.84 APE12-dist-out 20.75 APE11-dist-out 17.775 APE10-dist-out 19.752 APE9-dist-out 10.959 None None None XRAY 1.8 0.207 0.244 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r1y CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R28A 1 298 298.0 XA0:782 Type1 Inactive None 11.456 18.332 None -114.85, 140.61 83.61, 19.59 -63.53, 141.74 255.66, 87.36 75.77, -16.14 out-out out 15.853 Saltbr-out 16.606 HRD-in -90.15, -56.96 81.72, -19.73 out-out-out SNCooo out-out ActLoopNT-out 5.669 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -58.89, 107.19 APE9-dihe-na -65.35, 128.85 APE8-dihe-in -78.52, 121.12 APE8-rot-in 294.31 APE67-dihe-in -52.84, -26.8 -102.58, -3.56 APE12-dist-out 21.242 APE11-dist-out 17.369 APE10-dist-out 20.26 APE9-dist-out 11.224 None None None XRAY 1.75 0.204 0.256 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r28 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R6XA 1 298 298.0 X84:778 Type1 Inactive None 11.616 18.525 None -112.76, 145.27 77.03, 24.29 -64.96, 138.51 251.1, 86.55 78.86, -11.42 out-out out 15.599 Saltbr-out 16.687 HRD-in -91.18, -56.87 81.41, -17.78 out-out-out SNCooo out-out ActLoopNT-out 5.803 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -77.89, 119.44 APE9-dihe-na -60.25, 129.79 APE8-dihe-in -81.9, 126.65 APE8-rot-in 293.24 APE67-dihe-in -53.85, -27.75 -103.49, -2.87 APE12-dist-out 20.971 APE11-dist-out 17.332 APE10-dist-out 19.861 APE9-dist-out 11.004 None None None XRAY 1.75 0.198 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r6x CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R71A 1 298 298.0 X86:800 Type1 Inactive None 11.577 18.758 None -105.68, 148.59 72.24, 22.66 -59.47, 139.95 248.96, 87.94 80.85, -15.21 out-out out 15.516 Saltbr-out 16.195 HRD-in -93.08, -56.95 82.29, -19.56 out-out-out SNCooo out-out ActLoopNT-out 5.744 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.99, 123.25 APE9-dihe-na -70.56, 131.23 APE8-dihe-in -64.96, 140.3 APE8-rot-out 196.43 APE67-dihe-in -57.0, -27.71 -104.59, -0.92 APE12-dist-out 20.602 APE11-dist-out 17.729 APE10-dist-out 19.119 APE9-dist-out 10.651 None None None XRAY 1.75 0.209 0.237 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r71 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R73A 1 298 298.0 X87:920 Type1 Inactive None 11.655 18.593 None -113.72, 142.29 80.42, 22.84 -64.05, 138.77 253.65, 86.24 78.07, -8.79 out-out out 15.59 Saltbr-out 15.546 HRD-in -91.99, -58.09 83.71, -19.3 out-out-out SNCooo out-out ActLoopNT-out 5.832 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.42, 122.96 APE9-dihe-na -72.13, 133.83 APE8-dihe-in -82.06, 127.89 APE8-rot-in 303.64 APE67-dihe-in -52.93, -28.63 -103.22, -2.15 APE12-dist-out 20.907 APE11-dist-out 17.183 APE10-dist-out 19.838 APE9-dist-out 11.009 None None None XRAY 1.7 0.2 0.221 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r73 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R7EA 1 298 298.0 X88:919 Type1 Inactive None 11.325 18.478 None -107.54, 147.9 71.92, 27.82 -65.12, 136.21 243.68, 100.5 76.51, -6.15 out-out out 15.377 Saltbr-out 17.436 HRD-in -86.38, -57.25 81.31, -18.98 out-out-out SNCooo out-out ActLoopNT-out 5.727 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -57.64, 107.43 APE9-dihe-na -74.1, 129.96 APE8-dihe-in -74.77, 142.87 APE8-rot-out 90.22 APE67-dihe-in -54.91, -29.86 -109.18, 1.75 APE12-dist-out 21.034 APE11-dist-out 16.951 APE10-dist-out 19.596 APE9-dist-out 10.87 None None None XRAY 1.9 0.199 0.237 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r7e CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R7IA 1 298 298.0 X9I:505 Type1 Inactive None 11.369 18.564 None -113.0, 148.3 76.34, 21.13 -64.54, 139.22 245.45, 99.94 76.8, -11.16 out-out out 15.537 Saltbr-out 15.05 HRD-in -88.86, -59.71 85.14, -20.04 out-out-out SNCooo out-out ActLoopNT-out 5.731 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 118.01 APE9-dihe-na -55.02, 130.86 APE8-dihe-in -86.42, 128.86 APE8-rot-out 186.41 APE67-dihe-in -52.47, -29.57 -102.58, -3.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.743 APE9-dist-out 10.967 None None None XRAY 1.85 0.195 0.223 A 306 282 16 0 0 8 [[4, 286]] 1.0 3r7i CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R7UA 1 298 298.0 X96:523 Type1 Inactive None 11.369 18.665 None -111.2, 145.35 75.59, 25.93 -64.52, 137.61 245.01, 94.0 77.96, -11.73 out-out out 15.524 Saltbr-out 14.374 HRD-in -90.67, -56.58 81.34, -16.99 out-out-out SNCooo out-out ActLoopNT-out 5.758 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 130.63 APE9-dihe-na -60.27, 126.26 APE8-dihe-in -81.26, 130.03 APE8-rot-out 184.92 APE67-dihe-in -53.8, -28.22 -102.48, -2.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.57 APE9-dist-out 10.786 None None None XRAY 1.75 0.198 0.232 A 306 282 16 0 0 8 [[4, 286]] 1.0 3r7u CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R7VA 1 298 298.0 Z02:490 Type1 Inactive None 11.363 18.417 None -110.13, 148.48 72.96, 23.08 -62.99, 137.41 242.23, 98.62 77.48, -10.39 out-out out 15.292 Saltbr-out 16.932 HRD-in -89.74, -53.81 81.3, -23.16 out-out-out SNCooo out-out ActLoopNT-out 5.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.42, 108.48 APE9-dihe-na -68.89, 131.48 APE8-dihe-in -68.83, 138.12 APE8-rot-out 192.5 APE67-dihe-in -55.66, -29.18 -106.11, -4.25 APE12-dist-out 20.906 APE11-dist-out 16.882 APE10-dist-out 19.418 APE9-dist-out 10.836 None None None XRAY 1.95 0.188 0.228 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r7v CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R7YA 1 298 298.0 Z04:484 Type1 Inactive None 11.407 18.602 None -106.05, 149.21 72.28, 22.75 -60.56, 141.54 242.85, 100.98 77.08, -15.41 out-out out 15.509 Saltbr-out 17.635 HRD-in -92.8, -56.53 83.12, -18.85 out-out-out SNCooo out-out ActLoopNT-out 5.88 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.59, 125.71 APE9-dihe-na -71.8, 133.79 APE8-dihe-in -65.57, 140.02 APE8-rot-out 191.94 APE67-dihe-in -54.29, -31.44 -105.45, -2.12 APE12-dist-out 20.463 APE11-dist-out 17.742 APE10-dist-out 19.047 APE9-dist-out 10.621 None None None XRAY 1.9 0.191 0.218 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r7y CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R83A 1 298 298.0 Z14:589 Type1 Inactive None 11.533 18.764 None -108.4, 152.29 71.89, 22.89 -60.12, 136.31 246.86, 97.3 84.46, -13.15 out-out out 15.921 Saltbr-out 16.794 HRD-in -96.6, -56.11 81.89, -15.1 out-out-out SNCooo out-out ActLoopNT-out 6.071 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.86, 129.6 APE9-dihe-na -76.77, 128.27 APE8-dihe-in -63.71, 142.82 APE8-rot-out 188.48 APE67-dihe-in -52.24, -30.72 -105.79, -5.55 APE12-dist-out 20.357 APE11-dist-out 17.854 APE10-dist-out 19.066 APE9-dist-out 10.74 None None None XRAY 1.75 0.198 0.23 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r83 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R8UA 1 298 298.0 Z31:465 Type1 Inactive None 11.635 18.342 None -107.57, 143.44 81.21, 21.99 -62.01, 141.86 250.02, 87.35 78.29, -11.82 out-out out 15.359 Saltbr-out 16.228 HRD-in -90.94, -56.25 78.46, -9.5 out-out-out SNCooo out-out ActLoopNT-out 5.65 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -48.32, 111.28 APE9-dihe-na -78.48, 130.39 APE8-dihe-in -71.58, 132.49 APE8-rot-out 185.17 APE67-dihe-in -52.89, -31.15 -106.36, -2.37 APE12-dist-out 21.012 APE11-dist-out 17.405 APE10-dist-out 20.021 APE9-dist-out 10.955 None None None XRAY 2.0 0.2 0.236 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r8u CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R8VA 1 298 298.0 Z62:473 Type1 Inactive None 11.836 18.479 None -108.05, 152.25 77.1, 17.76 -60.61, 141.17 250.98, 94.27 79.61, -8.79 out-out out 15.78 Saltbr-out 17.037 HRD-in -95.62, -59.61 84.51, -14.19 out-out-out SNCooo out-out ActLoopNT-out 5.874 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -151.05, 140.69 APE9-dihe-na -102.28, 128.28 APE8-dihe-in -73.69, 133.66 APE8-rot-out 186.34 APE67-dihe-in -50.08, -28.19 -107.76, -6.89 APE12-dist-out 22.045 APE11-dist-out 18.616 APE10-dist-out 19.832 APE9-dist-out 11.207 None None None XRAY 1.9 0.192 0.229 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r8v CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3R9NA 1 298 298.0 Z68:529 Type1 Inactive None 11.778 18.357 None -111.04, 151.86 80.88, 16.04 -60.64, 141.85 253.93, 94.35 77.93, -10.08 out-out out 15.601 Saltbr-out 15.958 HRD-in -96.05, -60.18 85.28, -15.24 out-out-out SNCooo out-out ActLoopNT-out 5.825 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 129.61 APE9-dihe-na -90.33, 137.03 APE8-dihe-in -79.79, 134.05 APE8-rot-out 185.52 APE67-dihe-in -53.47, -28.97 -107.38, -1.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.812 APE9-dist-out 11.165 None None None XRAY 1.75 0.189 0.21 A 306 282 16 0 0 8 [[4, 286]] 1.0 3r9n CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RAHA 1 298 298.0 O1Z:516 Type1 Inactive None 11.796 18.355 None -110.29, 152.99 77.93, 18.04 -61.85, 142.5 252.0, 97.4 76.6, -9.77 out-out out 15.596 Saltbr-out 16.001 HRD-in -93.29, -59.77 84.17, -13.21 out-out-out SNCooo out-out ActLoopNT-out 5.763 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 126.0 APE9-dihe-na -86.71, 138.48 APE8-dihe-in -81.09, 133.18 APE8-rot-out 181.97 APE67-dihe-in -50.91, -30.54 -106.41, -3.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.851 APE9-dist-out 11.072 None None None XRAY 1.75 0.197 0.224 A 306 282 16 0 0 8 [[4, 286]] 1.0 3rah CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RAIA 1 298 298.0 X85:923 Type1 Inactive None 11.607 18.533 None -112.0, 145.89 74.76, 25.65 -65.32, 141.74 252.05, 86.7 75.22, -8.21 out-out out 15.233 Saltbr-out 16.738 HRD-in -91.9, -56.22 80.55, -18.43 out-out-out SNCooo out-out ActLoopNT-out 5.752 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -49.77, 110.97 APE9-dihe-na -68.15, 127.08 APE8-dihe-in -76.82, 124.51 APE8-rot-in 307.79 APE67-dihe-in -54.47, -28.12 -101.96, -2.13 APE12-dist-out 20.941 APE11-dist-out 17.332 APE10-dist-out 20.017 APE9-dist-out 11.059 None None None XRAY 1.7 0.206 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rai CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RM7A 1 298 298.0 19Z:654 Type1 Inactive None 11.446 18.412 None -110.62, 146.92 75.2, 22.58 -62.06, 138.87 244.23, 100.43 74.51, -5.06 out-out out 15.235 Saltbr-out 16.963 HRD-in -88.0, -57.21 81.55, -20.72 out-out-out SNCooo out-out ActLoopNT-out 5.742 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.65, 115.14 APE9-dihe-na -67.67, 126.3 APE8-dihe-in -75.61, 130.68 APE8-rot-in 296.31 APE67-dihe-in -54.47, -28.79 -106.07, -1.05 APE12-dist-out 21.303 APE11-dist-out 16.937 APE10-dist-out 19.596 APE9-dist-out 10.832 None None None XRAY 1.85 0.2 0.239 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rm7 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3ROYA 1 298 298.0 22Z:781 Type1 Inactive None 11.46 18.393 None -113.43, 143.96 78.34, 23.65 -63.28, 140.65 252.96, 88.59 73.47, -8.3 out-out out 15.717 Saltbr-out 12.931 HRD-in -88.52, -59.01 82.46, -18.91 out-out-out SNCooo out-out ActLoopNT-out 5.728 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -70.01, 109.19 APE9-dihe-na -59.45, 127.78 APE8-dihe-in -82.4, 126.58 APE8-rot-in 303.09 APE67-dihe-in -54.76, -26.31 -102.63, -0.93 APE12-dist-out 20.68 APE11-dist-out 17.278 APE10-dist-out 20.005 APE9-dist-out 11.083 None None None XRAY 1.75 0.203 0.239 A 306 294 4 0 0 0 [[4, 286]] 1.0 3roy CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RPOA 1 298 298.0 24Z:778 Type1 Inactive None 11.47 18.867 None -105.85, 149.39 71.39, 21.76 -61.36, 139.85 242.5, 91.57 76.43, -10.77 out-out out 15.707 Saltbr-out 16.039 HRD-in -92.26, -58.75 84.44, -19.22 out-out-out SNCooo out-out ActLoopNT-out 5.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.98, 126.83 APE9-dihe-na -72.5, 130.98 APE8-dihe-in -72.57, 140.79 APE8-rot-out 78.9 APE67-dihe-in -55.8, -27.77 -107.74, -1.05 APE12-dist-out 20.851 APE11-dist-out 17.697 APE10-dist-out 19.481 APE9-dist-out 10.877 None None None XRAY 1.75 0.198 0.226 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rpo CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3RPRA 1 298 298.0 25Z:529 Type1 Inactive None 11.844 18.444 None -111.94, 154.75 77.55, 17.41 -61.57, 142.53 250.82, 96.24 78.31, -12.31 out-out out 15.56 Saltbr-out 15.958 HRD-in -93.07, -60.25 84.58, -14.39 out-out-out SNCooo out-out ActLoopNT-out 5.748 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 136.43 APE9-dihe-na -85.09, 131.13 APE8-dihe-in -82.88, 126.09 APE8-rot-in 309.34 APE67-dihe-in -54.36, -26.86 -106.55, -1.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.993 APE9-dist-out 11.312 None None None XRAY 1.75 0.189 0.217 A 306 282 16 0 0 8 [[4, 286]] 1.0 3rpr CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3S00A 1 298 298.0 Z60:461 Type1 Inactive None 11.566 18.357 None -113.01, 158.12 73.15, 19.07 -62.76, 138.03 244.84, 103.73 75.94, -1.66 out-out out 15.467 Saltbr-out 16.207 HRD-in -93.79, -61.48 83.11, -12.57 out-out-out SNCooo out-out ActLoopNT-out 5.809 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.14, 127.34 APE9-dihe-na -83.29, 139.02 APE8-dihe-in -84.78, 133.09 APE8-rot-out 186.6 APE67-dihe-in -50.63, -29.06 -104.24, -5.63 APE12-dist-out 21.225 APE11-dist-out 18.093 APE10-dist-out 19.946 APE9-dist-out 11.217 None None None XRAY 1.8 0.216 0.251 A 306 294 4 0 0 0 [[4, 286]] 1.0 3s00 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6GUKA 1 298 298.0 FC8:301 Type1 Inactive None 11.495 18.296 None -105.76, 142.13 85.41, 11.26 -53.22, 139.96 258.83, 85.48 82.71, -9.99 out-out out 16.208 Saltbr-out 15.81 HRD-in -84.25, -64.23 86.29, -13.89 out-out-out SNCooo out-out ActLoopNT-out 5.784 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 126.62 APE8-dihe-in -72.63, 127.56 APE8-rot-out 192.14 APE67-dihe-in -62.77, -24.98 -100.92, -3.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.213 None None None XRAY 1.3 0.206 0.232 A 306 278 20 0 0 10 [[4, 286]] 1.0 6guk CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q48A 1 296 298.0 HHQ:302 Type1 Inactive None 11.735 18.081 None -106.16, 153.92 82.02, 17.32 -55.23, 142.63 259.92, 89.4 83.11, -15.88 out-out out 15.641 Saltbr-out 17.373 HRD-in -92.3, -63.2 83.34, -15.4 out-out-out SNCooo out-out ActLoopNT-out 5.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -92.12, 150.91 APE9-dihe-na -70.17, 141.74 APE8-dihe-in -85.56, 124.19 APE8-rot-in 313.51 APE67-dihe-in -62.02, -25.18 -103.39, -3.65 APE12-dist-none 999.0 APE11-dist-out 19.346 APE10-dist-out 20.001 APE9-dist-out 11.313 None None None XRAY 1.03 0.189 0.214 A 306 280 16 0 0 8 [[4, 286]] 1.0 6q48 CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q4AA 1 298 298.0 HGW:301 Type1 Inactive None 11.306 18.484 None -99.64, 151.34 71.13, 19.02 -56.46, 143.53 245.43, 97.69 75.11, -5.52 out-out out 15.394 Saltbr-out 16.363 HRD-in -87.49, -64.78 82.76, -10.85 out-out-out SNCooo out-out ActLoopNT-out 5.872 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -54.84, 127.77 APE9-dihe-na -73.06, 129.93 APE8-dihe-in -62.58, 141.11 APE8-rot-out 189.02 APE67-dihe-in -63.75, -25.74 -99.36, -2.17 APE12-dist-out 21.026 APE11-dist-out 17.754 APE10-dist-out 19.364 APE9-dist-out 10.597 None None None XRAY 1.13 0.184 0.22 A 306 292 6 0 0 0 [[4, 286]] 1.0 6q4a CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q4BA 1 298 298.0 HHN:301 Type1 Inactive None 11.287 18.407 None -101.91, 152.75 72.94, 19.11 -57.76, 142.71 248.24, 88.8 81.19, -13.46 out-out out 15.314 Saltbr-out 15.984 HRD-in -89.83, -61.58 81.31, -13.01 out-out-out SNCooo out-out ActLoopNT-out 5.665 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.3, 127.49 APE9-dihe-na -72.88, 129.85 APE8-dihe-in -66.95, 144.25 APE8-rot-out 190.39 APE67-dihe-in -63.63, -25.03 -98.0, -6.38 APE12-dist-out 21.153 APE11-dist-out 18.241 APE10-dist-out 19.458 APE9-dist-out 10.729 None None None XRAY 1.12 0.174 0.203 A 306 291 7 0 0 0 [[4, 286]] 1.0 6q4b CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q4EA 1 298 298.0 HH5:60303 Type1 Inactive None 11.63 18.238 None -103.98, 152.64 76.57, 26.47 -63.26, 142.69 253.01, 93.18 81.41, -12.31 out-out out 15.69 Saltbr-out 17.382 HRD-in -89.59, -63.45 82.73, -15.6 out-out-out SNCooo out-out ActLoopNT-out 5.872 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -85.93, 124.92 APE9-dihe-na -69.0, 134.19 APE8-dihe-in -81.8, 128.13 APE8-rot-in 317.48 APE67-dihe-in -63.28, -22.25 -98.83, -7.08 APE12-dist-none 999.0 APE11-dist-out 19.146 APE10-dist-out 19.915 APE9-dist-out 11.09 None None None XRAY 1.06 0.18 0.205 A 306 283 15 0 0 8 [[4, 286]] 1.0 6q4e CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q4FA 1 298 298.0 26D:60301 Type1 Inactive None 11.149 18.509 None -99.9, 150.98 69.26, 23.21 -68.2, 128.13 225.13, 109.26 95.17, -11.31 out-out out 15.504 Saltbr-out 17.136 HRD-in -92.63, -57.87 83.01, -20.55 out-out-out SNCooo out-out ActLoopNT-out 5.854 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.92, 124.88 APE9-dihe-na -71.16, 129.7 APE8-dihe-in -66.86, 140.78 APE8-rot-out 189.11 APE67-dihe-in -63.65, -26.7 -98.16, -5.09 APE12-dist-out 20.244 APE11-dist-out 17.335 APE10-dist-out 18.865 APE9-dist-out 10.511 None None OCS177 XRAY 1.21 0.169 0.205 A 306 291 7 0 0 0 [[4, 286]] 1.0 6q4f CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q4JA 1 298 298.0 HHB:60303 Type1 Inactive None 11.747 18.149 None -105.7, 151.51 81.04, 19.19 -56.11, 142.38 259.55, 88.13 81.71, -13.13 out-out out 15.722 Saltbr-out 16.957 HRD-in -91.04, -65.92 84.39, -14.99 out-out-out SNCooo out-out ActLoopNT-out 5.918 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -75.05, 123.68 APE9-dihe-na -83.72, 133.18 APE8-dihe-in -77.62, 129.92 APE8-rot-in 308.78 APE67-dihe-in -62.98, -23.89 -102.14, -4.26 APE12-dist-out 18.992 APE11-dist-out 17.065 APE10-dist-out 19.845 APE9-dist-out 11.16 None None None XRAY 1.05 0.167 0.186 A 306 288 10 0 0 2 [[4, 286]] 1.0 6q4j CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
7ZPCA 1 298 298.0 JLC:301 Type1 Inactive None 11.284 18.395 None -103.05, 151.04 70.8, 21.9 -57.66, 139.66 245.5, 92.68 84.19, -12.26 out-out out 15.619 Saltbr-out 17.181 HRD-in -90.47, -66.21 83.27, -5.36 out-out-out SNCooo out-out ActLoopNT-out 5.828 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.11, 126.85 APE9-dihe-na -73.86, 129.02 APE8-dihe-in -68.16, 141.96 APE8-rot-out 190.37 APE67-dihe-in -61.55, -25.3 -100.47, -4.17 APE12-dist-out 21.133 APE11-dist-out 18.201 APE10-dist-out 19.373 APE9-dist-out 10.555 None None None XRAY 1.4 0.202 0.221 A 306 291 7 0 0 0 [[4, 286]] 1.0 7zpc CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9GNOA 1 298 298.0 A1INI:301 Type1 Inactive None 11.354 18.311 None -111.15, 148.64 78.64, 18.41 -59.09, 139.63 256.45, 91.79 82.04, -13.45 out-out out 15.409 Saltbr-out 16.679 HRD-in -87.97, -59.85 82.33, -16.25 out-out-out SNCooo out-out ActLoopNT-out 5.939 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 129.23 APE9-dihe-na -76.58, 128.77 APE8-dihe-in -74.77, 135.66 APE8-rot-out 189.97 APE67-dihe-in -61.46, -24.46 -99.9, -1.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.15 APE9-dist-out 10.796 None None None XRAY 1.16 0.204 0.225 A 306 277 21 0 0 10 [[4, 286]] 1.0 9gno CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q3BA 1 298 298.0 PYZ:301,PYZ:302 Type1,Type1 Inactive None 11.695 18.369 None -99.21, 147.26 85.4, 20.21 -55.37, 141.31 259.87, 90.07 83.45, -13.95 out-out out 15.722 Saltbr-out 16.482 HRD-in -91.88, -62.73 83.2, -16.39 out-out-out SNCooo out-out ActLoopNT-out 5.862 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 105.63 APE9-dihe-na -77.44, 137.9 APE8-dihe-in -71.09, 136.23 APE8-rot-out 190.04 APE67-dihe-in -62.88, -22.27 -97.15, -7.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.81 APE9-dist-out 10.926 None None None XRAY 1.11 0.212 0.249 A 306 283 15 0 0 8 [[4, 286]] 1.0 6q3b CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
6Q3CA 2 298 298.0 BYZ:301,BYZ:302 Type1,Type1 Inactive None 11.011 18.345 None -105.89, 149.7 74.24, 21.25 -56.86, 140.5 243.36, 93.53 83.71, -11.42 out-out out 15.464 Saltbr-out 16.517 HRD-in -92.99, -59.73 78.01, -9.32 out-out-out SNCooo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.04, 126.39 APE9-dihe-na -72.41, 128.47 APE8-dihe-in -64.49, 140.67 APE8-rot-out 189.27 APE67-dihe-in -62.38, -27.04 -100.06, -1.63 APE12-dist-out 20.246 APE11-dist-out 17.53 APE10-dist-out 18.863 APE9-dist-out 10.38 None None OCS177 XRAY 1.29 0.142 0.178 A 306 289 8 0 0 0 [[4, 286]] 1.0 6q3c CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3EIDC 1 296 298.0 No_ligand No_ligand None DFGin 6.489 15.863 BLAminus -134.04, 176.12 56.38, 81.46 -98.21, 27.52 280.67, 71.27 -62.82, -36.83 in-in in 8.955 Saltbr-in 2.698 HRD-in -81.37, -49.78 74.95, -21.85 in-in-none SNCiin in-none ActLoopNT-in 2.833 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_inni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 125.0 APE8-dihe-in -62.75, 132.6 APE8-rot-in 299.6 APE67-dihe-in -57.24, -38.19 -61.24, -41.52 APE12-dist-in 13.922 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.564 None None None XRAY 3.15 0.207 0.261 C 298 290 6 0 0 2 [[4, 286]] 1.0 3eid CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
3EIDA 1 297 298.0 PO5:299 Type1 None DFGin 6.59 15.583 BLAminus -132.85, -177.52 48.93, 84.46 -100.76, 28.79 277.88, 66.9 -65.0, -34.5 in-in in 8.664 Saltbr-in 2.841 HRD-in -79.0, -48.15 75.16, -17.88 in-in-none SNCiin in-none ActLoopNT-in 2.891 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -96.83 APE9-dihe-na -46.53, 147.39 APE8-dihe-in -64.52, 140.51 APE8-rot-in 326.76 APE67-dihe-in -65.78, -38.63 -57.31, -43.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.918 APE9-dist-in 4.475 None None None XRAY 3.15 0.207 0.261 A 298 292 5 0 0 2 [[4, 286]] 1.0 3eid CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
9GOPA 1 298 298.0 A1IOI:60301 Type1 None DFGin 7.359 15.214 BLAminus -127.3, 173.02 54.03, 84.28 -99.69, 32.25 282.59, 81.45 -70.11, -42.44 in-in in 8.723 Saltbr-in 2.939 HRD-in -74.49, -42.35 70.77, -14.6 in-in-none SNCiin in-none ActLoopNT-in 2.913 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.86 APE8-dihe-in -65.97, 133.38 APE8-rot-in 277.05 APE67-dihe-in -57.91, -32.79 -19.7, -52.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.633 None None None XRAY 2.158 0.232 0.271 A 298 291 7 0 0 7 [[4, 286]] 1.0 9gop CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

CMGC_CDK2 (Cyclin-dependent kinase 2)

Total number of chains: 660
Active chains: 214
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 335 50.8% AF-P24941-K1A
DFGin BLBtrans 129 19.5% 1YKRA
DFGin BLBminus 92 13.9% 4GCJA
None None 64 9.7% 4KD1A
DFGin BLBplus 19 2.9% 2XNBA
DFGin None 17 2.6% 5UQ1C
DFGin ABAminus 3 0.5% 5NEVA
DFGout None 1 0.2% 5A14A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK2_HUMAN 4I3ZA P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.408 15.148 BLAminus -137.57, -176.06 52.96, 75.44 -91.33, 19.91 280.72, 70.75 -64.88, -19.38 in-in in 8.599 Saltbr-in 2.988 HRD-in -80.76, -55.87 72.55, 4.85 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.11, -96.25 APE9-dihe-na -51.92, 142.27 APE8-dihe-in -55.11, 135.08 APE8-rot-in 307.48 APE67-dihe-in -54.58, -26.51 -40.4, -56.95 APE12-dist-in 13.064 APE11-dist-in 10.585 APE10-dist-in 6.823 APE9-dist-in 3.305 None TPO160 TPO160 XRAY 2.05 0.199 0.228 A 296 296 0 0 0 0 [[4, 286]] 1.0 4i3z Homo sapiens CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4I3ZC P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.367 15.146 BLAminus -139.14, -175.0 51.64, 79.19 -95.11, 18.85 278.6, 70.91 -64.63, -17.11 in-in in 8.653 Saltbr-in 2.979 HRD-in -79.85, -55.96 72.81, 4.84 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.52, -96.18 APE9-dihe-na -52.61, 142.23 APE8-dihe-in -53.61, 133.4 APE8-rot-in 308.84 APE67-dihe-in -53.33, -28.57 -37.02, -58.54 APE12-dist-in 13.081 APE11-dist-in 10.618 APE10-dist-in 6.861 APE9-dist-in 3.305 None TPO160 TPO160 XRAY 2.05 0.199 0.228 C 296 296 0 0 0 0 [[4, 286]] 1.0 4i3z Homo sapiens CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QHRA P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.557 15.107 BLAminus -129.61, -176.27 55.27, 75.32 -97.07, 17.79 280.43, 72.68 -60.79, -23.59 in-in in 8.696 Saltbr-in 2.88 HRD-in -78.46, -57.59 71.9, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.99, 139.5 APE9-dihe-na 85.76, 129.74 APE8-dihe-in -56.31, 140.07 APE8-rot-in 302.24 APE67-dihe-in -65.07, -20.31 -41.24, -52.35 APE12-dist-in 12.989 APE11-dist-in 10.171 APE10-dist-in 7.111 APE9-dist-in 3.341 None TPO160 TPO160 XRAY 2.17 0.18 0.21 A 298 296 0 0 0 0 [[4, 286]] 1.0 3qhr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QHRC P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.565 15.121 BLAminus -133.25, -174.75 53.96, 72.74 -93.36, 15.91 281.14, 71.23 -60.56, -21.49 in-in in 8.7 Saltbr-in 2.868 HRD-in -78.47, -57.15 72.13, 9.85 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 147.52 APE9-dihe-na 81.05, 137.24 APE8-dihe-in -64.2, 137.48 APE8-rot-in 304.68 APE67-dihe-in -62.37, -22.27 -38.55, -53.11 APE12-dist-in 12.985 APE11-dist-in 10.232 APE10-dist-in 6.99 APE9-dist-in 3.293 None TPO160 TPO160 XRAY 2.17 0.18 0.21 C 298 296 0 0 0 0 [[4, 286]] 1.0 3qhr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QHWA P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.435 15.013 BLAminus -134.08, -174.07 54.44, 75.18 -91.31, 13.19 281.29, 72.4 -60.66, -23.16 in-in in 8.64 Saltbr-in 2.934 HRD-in -72.46, -52.11 70.84, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.61, -86.88 APE9-dihe-na -62.59, 147.47 APE8-dihe-in -61.56, 138.19 APE8-rot-in 297.56 APE67-dihe-in -60.69, -27.39 -44.54, -49.89 APE12-dist-in 12.995 APE11-dist-in 10.23 APE10-dist-in 6.782 APE9-dist-in 3.359 None TPO160 TPO160 XRAY 1.91 0.189 0.219 A 298 296 0 0 0 0 [[4, 286]] 1.0 3qhw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QHWC P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.453 15.083 BLAminus -135.33, -175.53 57.5, 71.73 -89.85, 9.67 280.79, 72.12 -55.86, -26.79 in-in in 8.617 Saltbr-in 2.896 HRD-in -73.76, -53.15 71.96, 3.16 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.86, -80.28 APE9-dihe-na -65.52, 146.91 APE8-dihe-in -61.19, 139.69 APE8-rot-in 298.69 APE67-dihe-in -57.2, -28.53 -47.15, -50.79 APE12-dist-in 12.997 APE11-dist-in 10.133 APE10-dist-in 6.722 APE9-dist-in 3.361 None TPO160 TPO160 XRAY 1.91 0.189 0.219 C 298 296 0 0 0 0 [[4, 286]] 1.0 3qhw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1JSTA P24941 1 298 298.0 ATP:300 ATPlike Active DFGin 6.427 15.464 BLAminus -139.88, 179.46 48.93, 78.76 -92.24, 30.29 284.11, 71.63 -70.08, -30.4 in-in in 8.717 Saltbr-in 2.757 HRD-in -78.76, -47.67 60.69, 17.81 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.53, 164.64 APE9-dihe-na 80.72, 135.16 APE8-dihe-in -62.71, 138.95 APE8-rot-in 293.52 APE67-dihe-in -51.22, -30.94 -33.79, -62.16 APE12-dist-in 13.121 APE11-dist-in 11.934 APE10-dist-in 7.067 APE9-dist-in 3.277 None TPO160 TPO160 XRAY 2.6 0.2 999.0 A 298 298 0 0 0 0 [[4, 286]] 1.0 1jst Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1JSTC P24941 1 298 298.0 ATP:300 ATPlike Active DFGin 6.225 15.133 BLAminus -133.76, 179.75 53.92, 86.29 -100.05, 15.63 279.16, 71.07 -59.91, -21.96 in-in in 8.679 Saltbr-in 2.947 HRD-in -76.84, -49.3 61.77, 13.04 in-in-in SNCiii in-in ActLoopNT-in 2.701 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.31, -163.7 APE9-dihe-na 66.67, 148.27 APE8-dihe-in -72.61, 126.34 APE8-rot-in 301.65 APE67-dihe-in -51.49, -27.24 -26.21, -64.21 APE12-dist-in 13.412 APE11-dist-in 12.741 APE10-dist-in 6.942 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.6 0.2 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 1jst Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2CJMA P24941 1 292 298.0 ATP:1294 ATPlike Active DFGin 6.412 15.477 BLAminus -133.49, 174.28 59.08, 80.72 -93.05, 17.33 280.25, 71.88 -51.1, -37.87 in-in in 8.875 Saltbr-in 3.027 HRD-in -83.77, -55.33 74.52, 15.85 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, -48.89 APE9-dihe-na -98.03, 148.0 APE8-dihe-in -53.4, 136.55 APE8-rot-in 296.67 APE67-dihe-in -56.28, -31.52 -52.78, -45.83 APE12-dist-in 13.329 APE11-dist-in 10.553 APE10-dist-in 7.18 APE9-dist-in 3.464 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 A 298 287 5 0 0 0 [[4, 286]] 1.0 2cjm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2CJMC P24941 1 297 298.0 ATP:1298 ATPlike Active DFGin 6.446 15.389 BLAminus -136.23, -173.15 48.46, 78.84 -90.01, 21.15 280.3, 74.36 -53.78, -24.47 in-in in 8.957 Saltbr-in 2.575 HRD-in -82.67, -49.67 67.53, 9.26 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -72.35 APE9-dihe-na -81.21, 139.76 APE8-dihe-in -48.67, 128.86 APE8-rot-in 299.02 APE67-dihe-in -54.58, -22.4 -47.31, -51.92 APE12-dist-in 13.068 APE11-dist-in 10.808 APE10-dist-in 7.009 APE9-dist-in 3.58 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 C 298 297 0 0 0 0 [[4, 286]] 1.0 2cjm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4II5A P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.295 15.275 BLAminus -136.76, -174.67 48.15, 75.69 -89.27, 15.07 281.74, 67.11 -54.49, -30.0 in-in in 8.675 Saltbr-in 2.898 HRD-in -77.95, -58.94 72.46, 5.93 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.58, 147.66 APE9-dihe-na 74.72, 130.64 APE8-dihe-in -63.5, 139.49 APE8-rot-in 303.89 APE67-dihe-in -59.35, -27.46 -47.25, -50.52 APE12-dist-in 13.127 APE11-dist-in 10.372 APE10-dist-in 7.034 APE9-dist-in 3.344 None TPO160 TPO160 XRAY 2.15 0.2 0.226 A 298 296 0 0 0 0 [[4, 286]] 1.0 4ii5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4II5C P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.289 15.288 BLAminus -134.89, -171.63 44.93, 79.89 -96.21, 16.02 275.02, 74.95 -60.79, -24.87 in-in in 8.666 Saltbr-in 2.94 HRD-in -77.09, -52.7 69.17, 3.7 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.65, 138.88 APE9-dihe-na 85.57, 133.69 APE8-dihe-in -65.51, 139.86 APE8-rot-in 305.2 APE67-dihe-in -60.76, -27.54 -47.35, -49.81 APE12-dist-in 13.141 APE11-dist-in 10.382 APE10-dist-in 7.061 APE9-dist-in 3.387 None TPO160 TPO160 XRAY 2.15 0.2 0.226 C 298 296 0 0 0 0 [[4, 286]] 1.0 4ii5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1GY3A P24941 1 296 298.0 ATP:1297 ATPlike Active DFGin 6.711 15.739 BLAminus -148.85, -171.85 44.28, 78.14 -91.55, 12.53 280.84, 73.84 -49.56, -35.56 in-in in 8.826 Saltbr-in 2.87 HRD-in -78.88, -56.55 74.04, 15.78 in-in-in SNCiii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.01, 152.98 APE9-dihe-na 75.99, 139.26 APE8-dihe-in -71.28, 139.34 APE8-rot-in 297.69 APE67-dihe-in -59.44, -30.42 -47.65, -49.93 APE12-dist-in 13.156 APE11-dist-in 10.678 APE10-dist-in 7.643 APE9-dist-in 3.395 None TPO160 TPO160 XRAY 2.7 0.25 0.313 A 299 296 0 0 0 0 [[4, 286]] 1.0 1gy3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1GY3C P24941 1 296 298.0 ATP:1298 ATPlike Active DFGin 6.824 15.376 BLAminus -159.42, -172.39 46.56, 69.8 -88.25, 18.8 278.1, 68.22 -63.28, -3.45 in-in in 8.61 Saltbr-in 3.316 HRD-in -72.89, -69.46 86.12, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.99, 145.31 APE9-dihe-na 77.28, 144.74 APE8-dihe-in -75.96, 137.92 APE8-rot-in 277.1 APE67-dihe-in -64.24, -30.46 -41.97, -49.4 APE12-dist-in 13.195 APE11-dist-in 10.636 APE10-dist-in 7.772 APE9-dist-in 3.212 None TPO160 TPO160 XRAY 2.7 0.25 0.313 C 299 296 0 0 0 0 [[4, 286]] 1.0 1gy3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1QMZA P24941 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.424 15.17 BLAminus -146.26, -172.65 47.53, 78.45 -93.94, 24.34 280.23, 76.95 -74.2, -4.32 in-in in 8.74 Saltbr-in 2.663 HRD-in -79.61, -61.2 70.52, 19.43 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.31, 152.76 APE9-dihe-na 72.53, 130.75 APE8-dihe-in -60.65, 130.8 APE8-rot-in 293.88 APE67-dihe-in -60.7, -26.37 -33.48, -54.72 APE12-dist-in 13.02 APE11-dist-in 10.095 APE10-dist-in 7.17 APE9-dist-in 3.235 None TPO160 TPO160 XRAY 2.2 0.22 0.28 A 299 296 0 0 0 0 [[4, 286]] 1.0 1qmz Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1QMZC P24941 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.512 15.134 BLAminus -147.61, -169.98 41.15, 80.53 -95.52, 25.6 283.09, 73.82 -79.03, -0.31 in-in in 8.74 Saltbr-in 2.54 HRD-in -75.88, -57.22 71.34, 18.39 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.04, 148.92 APE9-dihe-na 73.46, 130.58 APE8-dihe-in -61.75, 132.61 APE8-rot-in 296.97 APE67-dihe-in -70.09, -17.52 -37.4, -48.3 APE12-dist-in 12.947 APE11-dist-in 10.103 APE10-dist-in 7.19 APE9-dist-in 3.234 None TPO160 TPO160 XRAY 2.2 0.22 0.28 C 299 296 0 0 0 0 [[4, 286]] 1.0 1qmz Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2CCHA P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.648 15.496 BLAminus -138.14, 178.31 65.58, 62.78 -86.23, 16.74 281.6, 70.81 -63.75, -23.41 in-in in 8.795 Saltbr-in 2.828 HRD-in -78.21, -56.44 71.04, 15.24 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 152.64 APE9-dihe-na 69.68, 132.94 APE8-dihe-in -57.07, 137.05 APE8-rot-in 294.63 APE67-dihe-in -60.03, -20.02 -46.03, -52.89 APE12-dist-in 13.198 APE11-dist-in 10.36 APE10-dist-in 7.208 APE9-dist-in 3.286 None TPO160 TPO160 XRAY 1.7 0.15 0.182 A 299 296 0 0 0 0 [[4, 286]] 1.0 2cch Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2CCHC P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.477 15.382 BLAminus -137.71, -178.58 51.07, 78.61 -96.17, 22.01 279.1, 72.77 -65.43, -25.94 in-in in 8.653 Saltbr-in 2.719 HRD-in -81.45, -53.09 63.51, 17.55 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.56, 136.55 APE9-dihe-na 76.27, 128.23 APE8-dihe-in -59.37, 134.24 APE8-rot-in 303.33 APE67-dihe-in -63.22, -26.6 -41.45, -49.27 APE12-dist-in 12.866 APE11-dist-in 10.056 APE10-dist-in 7.377 APE9-dist-in 3.26 None TPO160 TPO160 XRAY 1.7 0.15 0.182 C 299 296 0 0 0 0 [[4, 286]] 1.0 2cch Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2CCIA P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.459 15.372 BLAminus -128.71, -173.86 48.01, 81.43 -98.73, 25.24 282.02, 74.31 -66.86, -20.71 in-in in 8.902 Saltbr-in 3.076 HRD-in -75.27, -47.91 58.22, 13.15 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.39, 140.99 APE9-dihe-na 76.14, 131.3 APE8-dihe-in -63.2, 133.24 APE8-rot-in 305.53 APE67-dihe-in -53.35, -21.65 -35.23, -63.18 APE12-dist-in 12.958 APE11-dist-in 10.323 APE10-dist-in 7.246 APE9-dist-in 3.291 None TPO160 TPO160 XRAY 2.7 0.264 0.321 A 299 296 0 0 0 0 [[4, 286]] 1.0 2cci Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2CCIC P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.232 15.382 BLAminus -129.31, 167.15 64.1, 86.76 -100.18, 28.53 276.86, 72.85 -63.26, -37.36 in-in in 8.551 Saltbr-in 2.666 HRD-in -73.66, -47.99 63.69, 10.4 in-in-in SNCiii in-in ActLoopNT-in 3.064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.2, 138.6 APE9-dihe-na 71.13, 137.9 APE8-dihe-in -63.98, 129.66 APE8-rot-in 301.4 APE67-dihe-in -61.96, -9.78 -29.15, -60.17 APE12-dist-in 12.753 APE11-dist-in 9.767 APE10-dist-in 7.42 APE9-dist-in 3.234 None TPO160 TPO160 XRAY 2.7 0.264 0.321 C 299 296 0 0 0 0 [[4, 286]] 1.0 2cci Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESOA P24941 1 298 298.0 W3A:60301 Allosteric Active DFGin 6.655 15.333 BLAminus -133.46, 169.39 64.14, 82.09 -97.29, 14.96 280.13, 78.42 -56.82, -27.72 in-in in 8.694 Saltbr-in 3.304 HRD-in -71.79, -59.63 73.42, 20.06 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 143.18 APE9-dihe-na 74.31, 127.7 APE8-dihe-in -57.08, 127.99 APE8-rot-in 287.92 APE67-dihe-in -62.74, -22.87 -45.7, -44.34 APE12-dist-in 12.977 APE11-dist-in 9.73 APE10-dist-in 7.242 APE9-dist-in 3.262 None TPO160 TPO160 XRAY 2.396 0.218 0.221 A 302 298 0 0 0 0 [[4, 286]] 1.0 9eso Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESYA P24941 1 296 298.0 HH8:60601,HH8:60602 Allosteric,Type1 Active DFGin 6.914 15.445 BLAminus -139.64, -178.33 56.3, 76.8 -98.54, 32.68 277.01, 73.22 -78.73, -25.27 in-in in 8.706 Saltbr-in 3.122 HRD-in -81.47, -55.44 76.61, 11.71 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.23, 175.02 APE9-dihe-na 74.59, 128.83 APE8-dihe-in -54.03, 132.08 APE8-rot-in 290.61 APE67-dihe-in -59.72, -15.02 -41.89, -48.16 APE12-dist-in 13.107 APE11-dist-in 12.117 APE10-dist-in 7.098 APE9-dist-in 3.172 None TPO160 TPO160 XRAY 2.394 0.257 0.262 A 302 296 0 0 0 0 [[4, 286]] 1.0 9esy Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET1A P24941 1 298 298.0 IJL:60301,IJL:60302 Allosteric,Type1 Active DFGin 6.61 15.432 BLAminus -137.66, 172.68 58.27, 87.59 -100.93, 20.0 276.6, 76.94 -60.98, -28.65 in-in in 8.734 Saltbr-in 3.047 HRD-in -76.58, -65.76 87.89, 15.93 in-in-in SNCiii in-in ActLoopNT-in 3.205 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.13, 164.18 APE9-dihe-na 77.58, 126.34 APE8-dihe-in -49.84, 134.42 APE8-rot-in 305.88 APE67-dihe-in -58.89, -21.26 -48.0, -52.41 APE12-dist-in 13.1 APE11-dist-in 12.196 APE10-dist-in 7.293 APE9-dist-in 3.194 None TPO160 TPO160 XRAY 2.394 0.221 0.228 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET2A P24941 1 298 298.0 IJX:60301,IJX:60302 Allosteric,Type1 Active DFGin 6.679 15.451 BLAminus -141.74, 173.34 57.73, 90.3 -103.65, 24.15 276.16, 73.44 -67.69, -32.25 in-in in 8.736 Saltbr-in 3.199 HRD-in -83.89, -59.32 78.42, 17.56 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.93, 164.85 APE9-dihe-na 78.45, 121.77 APE8-dihe-in -43.83, 132.89 APE8-rot-in 303.96 APE67-dihe-in -56.19, -21.95 -48.89, -51.57 APE12-dist-in 13.137 APE11-dist-in 11.976 APE10-dist-in 6.976 APE9-dist-in 3.288 None TPO160 TPO160 XRAY 2.37 0.229 0.231 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et2 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESOC P24941 1 296 298.0 W3A:60301,W3A:60302,W3A:60303 Allosteric,Type1,Allosteric Active DFGin 6.705 15.576 BLAminus -143.57, -178.71 50.73, 75.02 -85.85, 27.87 280.03, 72.76 -67.71, -29.24 in-in in 8.582 Saltbr-in 3.079 HRD-in -81.26, -57.04 69.4, 12.91 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.88, 143.3 APE9-dihe-na 78.39, 127.52 APE8-dihe-in -56.1, 139.77 APE8-rot-in 304.79 APE67-dihe-in -52.87, -28.83 -47.3, -55.08 APE12-dist-in 12.645 APE11-dist-in 9.983 APE10-dist-in 7.188 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.396 0.218 0.221 C 302 296 0 0 0 0 [[4, 286]] 1.0 9eso Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESQC P24941 1 296 298.0 IT4:60301,IT4:60302,IT4:60303 Allosteric,Type1,Allosteric Active DFGin 6.624 15.291 BLAminus -137.85, -178.69 52.7, 77.3 -90.27, 19.87 278.47, 77.01 -59.18, -26.94 in-in in 8.607 Saltbr-in 2.858 HRD-in -78.68, -58.44 73.58, 9.59 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.68, 150.97 APE9-dihe-na 74.26, 123.88 APE8-dihe-in -48.22, 139.44 APE8-rot-in 303.28 APE67-dihe-in -59.57, -21.54 -47.89, -52.58 APE12-dist-in 12.948 APE11-dist-in 10.21 APE10-dist-in 6.851 APE9-dist-in 3.189 None TPO160 TPO160 XRAY 2.38 0.206 0.21 C 302 266 30 0 0 0 [[4, 286]] 1.0 9esq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET8A P24941 1 298 298.0 IIS:60601,IIS:60602,IIS:60603 Allosteric,Type1,Allosteric Active DFGin 6.66 15.267 BLAminus -132.18, 175.72 56.92, 87.06 -99.25, 17.56 279.65, 74.77 -56.71, -31.95 in-in in 8.83 Saltbr-in 2.915 HRD-in -79.06, -57.11 80.34, 14.99 in-in-in SNCiii in-in ActLoopNT-in 3.01 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.88, 138.7 APE9-dihe-na 86.37, 127.57 APE8-dihe-in -49.12, 131.32 APE8-rot-in 301.39 APE67-dihe-in -60.3, -18.72 -49.04, -49.16 APE12-dist-in 13.188 APE11-dist-in 10.728 APE10-dist-in 7.284 APE9-dist-in 3.31 None TPO160 TPO160 XRAY 2.31 0.226 0.242 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et8 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESSA P24941 1 298 298.0 UUG:60601,UUG:60603,UUG:60604,UUG:60605 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.695 15.291 BLAminus -143.55, -172.69 50.57, 82.8 -101.61, 18.26 274.16, 75.73 -70.34, -22.45 in-in in 8.76 Saltbr-in 3.285 HRD-in -76.11, -53.71 67.29, 25.09 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.09, 136.89 APE9-dihe-na 78.9, 132.52 APE8-dihe-in -60.77, 137.94 APE8-rot-in 287.48 APE67-dihe-in -68.63, -13.58 -48.45, -45.96 APE12-dist-in 12.975 APE11-dist-in 10.05 APE10-dist-in 7.581 APE9-dist-in 3.313 None TPO160 TPO160 XRAY 2.44 0.212 0.219 A 302 298 0 0 0 0 [[4, 286]] 1.0 9ess Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESWA P24941 1 294 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.515 15.297 BLAminus -143.94, 174.07 58.52, 82.55 -94.4, 25.35 278.47, 68.95 -74.76, -22.16 in-in in 8.637 Saltbr-in 3.197 HRD-in -81.26, -58.57 77.56, 16.21 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -61.44, 160.94 APE9-dihe-na 81.67, 126.4 APE8-dihe-in -51.25, 136.17 APE8-rot-in 300.7 APE67-dihe-in -59.48, -16.12 -52.59, -48.63 APE12-dist-in 12.997 APE11-dist-in 11.897 APE10-dist-in 7.023 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.38 0.233 0.239 A 302 294 0 0 0 0 [[4, 286]] 1.0 9esw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESWC P24941 1 296 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.576 15.209 BLAminus -137.9, -176.23 48.55, 71.41 -85.05, 25.18 283.44, 66.65 -62.35, -32.95 in-in in 8.417 Saltbr-in 2.763 HRD-in -83.58, -58.72 75.84, 9.9 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.32, 151.2 APE9-dihe-na 72.23, 131.64 APE8-dihe-in -58.77, 140.82 APE8-rot-in 312.4 APE67-dihe-in -51.92, -26.23 -42.04, -57.02 APE12-dist-in 12.776 APE11-dist-in 10.195 APE10-dist-in 6.943 APE9-dist-in 3.236 None TPO160 TPO160 XRAY 2.38 0.233 0.239 C 302 269 27 0 0 0 [[4, 286]] 1.0 9esw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ETBA P24941 1 298 298.0 PYZ:60601,PYZ:60602,PYZ:60604,PYZ:60606 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.68 15.57 BLAminus -134.02, 179.89 52.18, 79.05 -90.46, 32.64 275.32, 74.18 -73.39, -29.97 in-in in 8.617 Saltbr-in 3.479 HRD-in -84.14, -59.82 72.65, 14.59 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.68, 145.25 APE9-dihe-na 77.56, 126.12 APE8-dihe-in -50.85, 139.31 APE8-rot-in 306.09 APE67-dihe-in -53.89, -21.84 -51.66, -56.12 APE12-dist-in 12.679 APE11-dist-in 10.342 APE10-dist-in 7.102 APE9-dist-in 3.205 None TPO160 TPO160 XRAY 2.76 0.213 0.228 A 302 298 0 0 0 0 [[4, 286]] 1.0 9etb Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET3A P24941 1 297 298.0 1P8:60601,1P8:60602,1P8:60603,1P8:60604,1P8:60605 Allosteric,Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.653 15.601 BLAminus -136.82, -177.27 50.45, 80.79 -92.99, 23.2 280.0, 68.99 -67.99, -23.36 in-in in 9.13 Saltbr-in 3.089 HRD-in -81.22, -55.89 79.56, 15.53 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.46, 155.27 APE9-dihe-na 71.1, 130.63 APE8-dihe-in -56.13, 132.54 APE8-rot-in 297.17 APE67-dihe-in -61.85, -18.92 -41.84, -50.03 APE12-dist-in 12.934 APE11-dist-in 10.614 APE10-dist-in 6.973 APE9-dist-in 3.165 None TPO160 TPO160 XRAY 2.34 0.185 0.221 A 302 293 4 0 0 0 [[4, 286]] 1.0 9et3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET9A P24941 1 297 298.0 HEW:60801,HEW:60802,HEW:60803,HEW:60804,HEW:60805 Allosteric,Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.572 15.409 BLAminus -133.96, -177.38 53.45, 84.64 -98.13, 25.94 274.26, 70.21 -74.85, -27.45 in-in in 8.735 Saltbr-in 3.059 HRD-in -78.44, -57.38 73.64, 19.34 in-in-in SNCiii in-in ActLoopNT-in 3.04 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.56, 159.19 APE9-dihe-na 80.63, 125.87 APE8-dihe-in -49.88, 140.65 APE8-rot-in 303.1 APE67-dihe-in -56.41, -19.57 -59.45, -45.78 APE12-dist-in 12.894 APE11-dist-in 11.889 APE10-dist-in 7.25 APE9-dist-in 3.35 None TPO160 TPO160 XRAY 2.494 0.225 0.246 A 302 293 4 0 0 0 [[4, 286]] 1.0 9et9 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET6A P24941 1 298 298.0 HHQ:60301,HHQ:60302,HHQ:60303,HHQ:60304,HHQ:60305 Allosteric,Type1,Type1,Allosteric,Allosteric Active DFGin 6.558 15.4 BLAminus -138.32, 174.17 59.16, 82.89 -97.52, 24.91 277.51, 70.1 -66.81, -32.16 in-in in 8.683 Saltbr-in 3.289 HRD-in -83.72, -58.26 76.77, 19.99 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.68, 144.14 APE9-dihe-na 73.74, 127.27 APE8-dihe-in -53.01, 138.45 APE8-rot-in 290.69 APE67-dihe-in -56.0, -15.28 -49.45, -51.36 APE12-dist-in 12.736 APE11-dist-in 9.969 APE10-dist-in 7.114 APE9-dist-in 3.193 None TPO160 TPO160 XRAY 2.553 0.224 0.239 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et6 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESRA P24941 1 296 298.0 UU1:60301,UU1:60302,UU1:60303,UU1:60304,UU1:60305 Allosteric,Type1,Type1.5_Back,Allosteric,Allosteric Active DFGin 6.484 15.309 BLAminus -137.71, 177.29 60.74, 79.75 -94.6, 19.0 278.66, 72.46 -62.93, -24.14 in-in in 8.52 Saltbr-in 2.909 HRD-in -79.16, -56.26 72.4, 14.4 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.11, 140.47 APE9-dihe-na 79.92, 128.53 APE8-dihe-in -50.99, 136.74 APE8-rot-in 298.81 APE67-dihe-in -64.23, -18.66 -49.35, -47.37 APE12-dist-in 13.04 APE11-dist-in 10.052 APE10-dist-in 7.551 APE9-dist-in 3.189 None TPO160 TPO160 XRAY 2.388 0.221 0.227 A 302 296 0 0 0 0 [[4, 286]] 1.0 9esr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN AF-P24941-K1A P24941 1 294 298.0 No_ligand No_ligand Active DFGin 6.87 15.12 BLAminus -140.16, 178.48 51.28, 62.88 -73.79, 18.94 281.96, 71.73 -61.73, -34.21 in-in in 8.723 Saltbr-in 2.752 HRD-in -75.84, -45.79 60.33, 14.5 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.09, 162.34 APE9-dihe-na 63.24, 130.57 APE8-dihe-in -56.84, 135.78 APE8-rot-in 300.07 APE67-dihe-in -65.59, -21.55 -45.5, -46.3 APE12-dist-in 13.242 APE11-dist-in 10.497 APE10-dist-in 6.74 APE9-dist-in 3.241 None None None AF2 -1.0 1.0 1.0 A 294 294 0 0 0 0 [[4, 286]] 1.0 AF-P24941-K1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN AF-P24941-K3A P24941 1 294 298.0 No_ligand No_ligand Active DFGin 6.701 14.889 BLAminus -138.95, 173.67 56.67, 67.47 -77.4, 14.05 281.26, 73.57 -59.19, -32.42 in-in in 8.892 Saltbr-in 2.748 HRD-in -77.57, -50.77 62.52, 12.86 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.32, 156.27 APE9-dihe-na 61.76, 135.58 APE8-dihe-in -57.29, 134.08 APE8-rot-in 293.31 APE67-dihe-in -62.83, -23.25 -42.68, -46.29 APE12-dist-in 13.022 APE11-dist-in 10.357 APE10-dist-in 6.753 APE9-dist-in 3.607 None None None AF2 -1.0 1.0 1.0 A 294 294 0 0 0 0 [[4, 286]] 1.0 AF-P24941-K3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1W98A P24941 1 297 298.0 No_ligand No_ligand Active DFGin 6.855 15.477 BLAminus -132.29, 179.27 46.85, 78.35 -90.78, 21.68 284.84, 67.75 -61.81, -18.58 in-in in 8.448 Saltbr-in 2.715 HRD-in -74.94, -55.42 68.56, 13.89 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.09, 148.28 APE9-dihe-na 71.04, 132.45 APE8-dihe-in -53.61, 138.48 APE8-rot-in 298.56 APE67-dihe-in -62.06, -26.5 -45.15, -51.76 APE12-dist-in 13.068 APE11-dist-in 10.311 APE10-dist-in 7.193 APE9-dist-in 3.398 None TPO160 TPO160 XRAY 2.15 0.185 0.246 A 298 297 0 0 0 0 [[4, 286]] 1.0 1w98 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9D0XC P24941 1 298 298.0 No_ligand No_ligand Active DFGin 7.0 15.676 BLAminus -151.46, 172.31 59.96, 64.3 -82.59, 17.66 276.98, 76.95 -63.84, -32.64 in-in in 8.951 Saltbr-in 3.428 HRD-in -67.19, -51.2 63.12, 7.43 in-in-in SNCiii in-in ActLoopNT-in 2.592 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.32, 161.64 APE9-dihe-na 72.61, 147.92 APE8-dihe-in -61.5, 150.78 APE8-rot-in 307.57 APE67-dihe-in -61.25, -23.58 -59.12, -41.43 APE12-dist-in 13.477 APE11-dist-in 12.123 APE10-dist-in 7.571 APE9-dist-in 3.249 None TPO160 TPO160 EM 2.84 999.0 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 9d0x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7E34A P24941 2 298 298.0 No_ligand No_ligand Active DFGin 6.812 15.562 BLAminus -114.43, 175.14 51.52, 82.42 -93.73, 25.75 279.61, 78.85 -57.86, -47.09 in-in in 9.156 Saltbr-in 3.378 HRD-in -73.23, -37.35 52.55, 11.13 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.03, -54.07 APE9-dihe-na -126.84, 162.29 APE8-dihe-in -56.38, 143.49 APE8-rot-in 320.41 APE67-dihe-in -49.11, -31.47 -45.62, -51.01 APE12-dist-in 12.702 APE11-dist-in 9.666 APE10-dist-in 6.692 APE9-dist-in 3.735 None None None XRAY 3.19 0.254 0.3 A 298 297 0 0 0 0 [[4, 286]] 1.0 7e34 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6ATHA P24941 17 298 298.0 No_ligand No_ligand Active DFGin 6.631 16.043 BLAminus -135.63, 173.86 60.0, 77.46 -94.47, 18.0 282.61, 72.18 -60.46, -25.8 in-in in 9.941 Saltbr-in 3.267 HRD-in -79.47, -50.85 66.96, 12.32 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.35, 169.25 APE9-dihe-na 76.92, 132.44 APE8-dihe-in -54.22, 134.87 APE8-rot-in 293.42 APE67-dihe-in -59.54, -22.0 -46.19, -51.14 APE12-dist-in 13.34 APE11-dist-in 12.372 APE10-dist-in 7.47 APE9-dist-in 3.28 None TPO160 TPO160 XRAY 1.82 0.172 0.187 A 300 278 17 0 0 0 [[4, 286]] 1.0 6ath Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5UQ1A P24941 3 296 298.0 No_ligand No_ligand Active DFGin 6.835 15.413 BLAminus -144.0, 176.17 61.82, 68.28 -90.54, 36.8 291.1, 72.25 -74.36, -28.15 in-in in 9.413 Saltbr-in 3.088 HRD-in -82.91, -48.78 54.78, 42.34 in-in-in SNCiii in-in ActLoopNT-in 2.586 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.16, -41.16 APE9-dihe-na -160.3, 150.42 APE8-dihe-in -56.62, 128.17 APE8-rot-in 302.57 APE67-dihe-in -53.1, -29.41 -31.23, -43.06 APE12-dist-in 12.606 APE11-dist-in 8.748 APE10-dist-in 7.404 APE9-dist-in 4.537 None None None XRAY 3.201 0.208 0.261 A 301 288 6 0 0 0 [[4, 286]] 1.0 5uq1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H24C P24941 1 293 298.0 No_ligand No_ligand Active DFGin 6.559 15.596 BLAminus -133.49, 175.31 53.76, 89.78 -103.42, 21.65 275.45, 80.97 -62.92, -37.77 in-in in 9.12 Saltbr-in 2.85 HRD-in -91.23, -52.77 60.11, 22.43 in-in-in SNCiii in-in ActLoopNT-in 2.657 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.82, 140.74 APE9-dihe-na 80.17, 132.23 APE8-dihe-in -55.87, 134.79 APE8-rot-in 288.67 APE67-dihe-in -70.66, -27.96 -51.17, -32.98 APE12-dist-in 12.694 APE11-dist-in 10.75 APE10-dist-in 7.289 APE9-dist-in 3.425 None TPO160 TPO160 XRAY 2.5 0.212 0.27 C 303 293 0 0 0 0 [[4, 286]] 1.0 1h24 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H25A P24941 1 293 298.0 No_ligand No_ligand Active DFGin 6.427 15.421 BLAminus -140.43, 173.99 67.64, 67.87 -81.25, 30.24 283.91, 68.58 -68.15, -35.9 in-in in 8.89 Saltbr-in 2.491 HRD-in -74.21, -51.05 67.2, 22.05 in-in-in SNCiii in-in ActLoopNT-in 3.004 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.81, 141.17 APE9-dihe-na 80.54, 129.65 APE8-dihe-in -46.03, 134.66 APE8-rot-in 297.67 APE67-dihe-in -59.41, -24.06 -45.9, -50.57 APE12-dist-in 13.403 APE11-dist-in 10.774 APE10-dist-in 7.873 APE9-dist-in 3.359 None TPO160 TPO160 XRAY 2.5 0.249 0.266 A 303 293 0 0 0 0 [[4, 286]] 1.0 1h25 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H25C P24941 1 293 298.0 No_ligand No_ligand Active DFGin 6.343 15.678 BLAminus -141.54, -162.96 43.33, 68.33 -81.52, 26.81 277.02, 71.89 -64.81, -42.11 in-in in 8.699 Saltbr-in 3.448 HRD-in -78.87, -55.84 74.39, 8.92 in-in-in SNCiii in-in ActLoopNT-in 2.629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.27, 141.45 APE9-dihe-na 77.04, 118.84 APE8-dihe-in -50.03, 137.75 APE8-rot-in 297.84 APE67-dihe-in -53.34, -34.93 -38.84, -62.46 APE12-dist-in 12.711 APE11-dist-in 9.904 APE10-dist-in 7.219 APE9-dist-in 3.561 None TPO160 TPO160 XRAY 2.5 0.249 0.266 C 303 278 15 0 0 0 [[4, 286]] 1.0 1h25 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H26A P24941 1 297 298.0 No_ligand No_ligand Active DFGin 6.707 15.231 BLAminus -130.74, 179.93 49.99, 80.78 -90.99, 22.63 278.59, 67.54 -55.88, -33.36 in-in in 8.513 Saltbr-in 3.0 HRD-in -87.47, -56.42 74.36, 10.84 in-in-in SNCiii in-in ActLoopNT-in 3.046 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.15, 132.37 APE9-dihe-na 88.39, 126.79 APE8-dihe-in -50.94, 133.96 APE8-rot-in 297.34 APE67-dihe-in -61.54, -24.84 -43.64, -49.19 APE12-dist-in 13.287 APE11-dist-in 10.417 APE10-dist-in 7.729 APE9-dist-in 3.129 None TPO160 TPO160 XRAY 2.24 0.219 0.268 A 303 297 0 0 0 0 [[4, 286]] 1.0 1h26 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H26C P24941 1 297 298.0 No_ligand No_ligand Active DFGin 6.338 15.189 BLAminus -129.56, -170.99 38.09, 89.21 -96.19, 16.9 282.78, 62.93 -51.84, -27.15 in-in in 8.523 Saltbr-in 2.643 HRD-in -83.53, -52.88 73.72, 5.54 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.19, 136.75 APE9-dihe-na 80.79, 120.39 APE8-dihe-in -42.38, 138.45 APE8-rot-in 303.56 APE67-dihe-in -41.05, -33.69 -41.82, -70.9 APE12-dist-in 12.985 APE11-dist-in 10.015 APE10-dist-in 7.058 APE9-dist-in 3.268 None TPO160 TPO160 XRAY 2.24 0.219 0.268 C 303 268 29 0 0 0 [[4, 286]] 1.0 1h26 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H27A P24941 1 297 298.0 No_ligand No_ligand Active DFGin 6.664 15.323 BLAminus -140.7, 165.59 63.58, 80.1 -95.0, 28.03 281.73, 75.96 -81.22, -9.66 in-in in 8.874 Saltbr-in 2.671 HRD-in -79.12, -57.48 75.49, 12.57 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.15, 141.66 APE9-dihe-na 83.31, 128.91 APE8-dihe-in -54.93, 124.96 APE8-rot-in 299.96 APE67-dihe-in -61.78, -15.18 -31.34, -53.69 APE12-dist-in 13.361 APE11-dist-in 10.737 APE10-dist-in 7.53 APE9-dist-in 3.422 None TPO160 TPO160 XRAY 2.2 0.229 0.269 A 303 297 0 0 0 0 [[4, 286]] 1.0 1h27 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H27C P24941 1 297 298.0 No_ligand No_ligand Active DFGin 6.535 15.698 BLAminus -141.01, -170.97 48.58, 73.87 -90.7, 21.51 277.96, 73.03 -70.2, -20.66 in-in in 8.877 Saltbr-in 2.648 HRD-in -74.45, -56.61 75.47, 6.24 in-in-in SNCiii in-in ActLoopNT-in 2.955 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.35, -75.83 APE9-dihe-na -78.83, 147.21 APE8-dihe-in -56.74, 130.79 APE8-rot-in 291.88 APE67-dihe-in -55.62, -23.64 -43.11, -54.87 APE12-dist-in 12.872 APE11-dist-in 10.336 APE10-dist-in 6.962 APE9-dist-in 3.374 None TPO160 TPO160 XRAY 2.2 0.229 0.269 C 303 292 5 0 0 0 [[4, 286]] 1.0 1h27 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H28A P24941 1 296 298.0 No_ligand No_ligand Active DFGin 6.384 15.718 BLAminus -153.46, -159.87 20.57, 88.57 -91.81, 11.41 271.46, 74.18 -25.9, -52.81 in-in in 8.594 Saltbr-in 2.264 HRD-in -88.8, -49.46 64.93, 15.35 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.92, 144.97 APE9-dihe-na 70.46, 137.31 APE8-dihe-in -53.73, 137.05 APE8-rot-in 271.77 APE67-dihe-in -55.48, -34.45 -39.84, -54.18 APE12-dist-in 13.112 APE11-dist-in 10.31 APE10-dist-in 7.809 APE9-dist-in 3.74 None TPO160 TPO160 XRAY 2.8 0.247 0.323 A 303 296 0 0 0 0 [[4, 286]] 1.0 1h28 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H28C P24941 1 296 298.0 No_ligand No_ligand Active DFGin 6.686 15.554 BLAminus -122.17, -174.1 31.91, 98.77 -105.16, 25.64 276.4, 56.93 -56.63, -37.84 in-in in 8.545 Saltbr-in 2.532 HRD-in -78.4, -59.25 76.05, 21.74 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.12, 142.55 APE9-dihe-na 66.77, 132.32 APE8-dihe-in -51.48, 150.45 APE8-rot-in 338.46 APE67-dihe-in -93.0, -26.08 -62.43, -23.05 APE12-dist-in 12.871 APE11-dist-in 10.574 APE10-dist-in 7.86 APE9-dist-in 3.802 None TPO160 TPO160 XRAY 2.8 0.247 0.323 C 303 296 0 0 0 0 [[4, 286]] 1.0 1h28 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WMAA P24941 1 296 298.0 No_ligand No_ligand Active DFGin 6.568 15.049 BLAminus -133.6, 177.0 58.82, 73.66 -85.95, 28.46 282.46, 64.37 -59.09, -39.37 in-in in 8.168 Saltbr-in 2.667 HRD-in -79.36, -47.13 63.08, 19.5 in-in-in SNCiii in-in ActLoopNT-in 3.004 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.91, 131.32 APE9-dihe-na 75.18, 124.55 APE8-dihe-in -49.63, 128.6 APE8-rot-in 283.16 APE67-dihe-in -57.29, -20.52 -38.45, -49.54 APE12-dist-in 12.747 APE11-dist-in 10.156 APE10-dist-in 7.672 APE9-dist-in 3.225 None TPO160 TPO160 XRAY 2.8 0.215 0.285 A 303 296 0 0 0 0 [[4, 286]] 1.0 2wma Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WMAC P24941 1 296 298.0 No_ligand No_ligand Active DFGin 6.384 15.12 BLAminus -145.3, 179.74 48.13, 83.21 -99.37, 24.44 286.5, 69.16 -57.18, -31.45 in-in in 8.519 Saltbr-in 2.795 HRD-in -78.02, -42.4 57.96, 17.28 in-in-in SNCiii in-in ActLoopNT-in 2.753 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.94, 135.9 APE9-dihe-na 64.4, 130.25 APE8-dihe-in -51.81, 136.9 APE8-rot-in 318.83 APE67-dihe-in -40.81, -43.76 -29.69, -71.87 APE12-dist-in 12.702 APE11-dist-in 9.769 APE10-dist-in 7.287 APE9-dist-in 3.312 None TPO160 TPO160 XRAY 2.8 0.215 0.285 C 303 265 31 0 0 0 [[4, 286]] 1.0 2wma Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WMBA P24941 1 296 298.0 No_ligand No_ligand Active DFGin 6.718 15.377 BLAminus -140.8, -179.02 50.24, 83.38 -90.13, 17.15 282.82, 68.9 -48.57, -40.04 in-in in 8.365 Saltbr-in 2.97 HRD-in -81.54, -49.33 66.55, 12.35 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.2, 132.18 APE9-dihe-na 83.05, 127.74 APE8-dihe-in -45.93, 124.86 APE8-rot-in 308.22 APE67-dihe-in -58.22, -25.45 -31.78, -52.64 APE12-dist-in 13.149 APE11-dist-in 10.722 APE10-dist-in 7.949 APE9-dist-in 3.244 None TPO160 TPO160 XRAY 2.6 0.23 0.296 A 303 296 0 0 0 0 [[4, 286]] 1.0 2wmb Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WMBC P24941 1 296 298.0 No_ligand No_ligand Active DFGin 6.463 15.325 BLAminus -121.15, -178.34 51.45, 79.71 -90.23, 12.63 281.15, 73.22 -54.7, -15.77 in-in in 8.587 Saltbr-in 2.899 HRD-in -77.23, -49.1 61.52, 12.87 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.73, 141.58 APE9-dihe-na 70.76, 130.78 APE8-dihe-in -56.01, 124.97 APE8-rot-in 294.6 APE67-dihe-in -44.5, -27.37 -20.9, -71.13 APE12-dist-in 13.185 APE11-dist-in 10.089 APE10-dist-in 7.246 APE9-dist-in 3.459 None TPO160 TPO160 XRAY 2.6 0.23 0.296 C 303 266 30 0 0 0 [[4, 286]] 1.0 2wmb Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EONA P24941 1 298 298.0 1RO:60301 Type1 Active DFGin 6.679 15.186 BLAminus -132.11, -177.66 48.8, 80.61 -94.87, 18.24 280.36, 73.55 -57.79, -34.94 in-in in 8.417 Saltbr-in 2.663 HRD-in -75.86, -51.78 66.0, 6.82 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.44, 146.03 APE9-dihe-na 76.94, 130.44 APE8-dihe-in -52.16, 130.55 APE8-rot-in 300.04 APE67-dihe-in -53.56, -30.12 -41.06, -53.76 APE12-dist-in 13.016 APE11-dist-in 9.38 APE10-dist-in 7.36 APE9-dist-in 3.322 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.4 0.22 0.254 A 300 298 0 0 0 0 [[4, 286]] 1.0 4eon Homo sapiens CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EONC P24941 1 297 298.0 1RO:60301 Type1 Active DFGin 6.664 14.9 BLAminus -139.87, -179.08 50.46, 76.36 -91.39, 25.02 285.74, 73.68 -64.04, -29.23 in-in in 8.338 Saltbr-in 2.47 HRD-in -73.01, -51.76 68.43, 8.79 in-in-in SNCiii in-in ActLoopNT-in 3.015 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 64.41, -8.92 APE9-dihe-na -162.15, 137.23 APE8-dihe-in -47.67, 127.68 APE8-rot-in 293.44 APE67-dihe-in -59.95, -25.08 -45.92, -47.24 APE12-dist-in 13.349 APE11-dist-in 9.451 APE10-dist-in 7.991 APE9-dist-in 3.629 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.4 0.22 0.254 C 300 297 0 0 0 0 [[4, 286]] 1.0 4eon Homo sapiens CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOIA P24941 1 298 298.0 1RO:60301 Type1 Active DFGin 6.572 14.887 BLAminus -136.09, 178.06 51.98, 76.26 -88.79, 18.92 282.78, 68.24 -58.67, -31.37 in-in in 8.4 Saltbr-in 2.764 HRD-in -78.65, -54.06 69.38, 12.33 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.33, 164.84 APE9-dihe-na 77.52, 131.19 APE8-dihe-in -50.1, 134.54 APE8-rot-in 303.3 APE67-dihe-in -59.45, -22.81 -46.35, -50.05 APE12-dist-in 13.354 APE11-dist-in 12.335 APE10-dist-in 7.479 APE9-dist-in 3.268 K89D,Q131E TPO160 TPO160 XRAY 2.0 0.215 0.234 A 299 294 4 0 0 0 [[4, 286]] 1.0 4eoi Homo sapiens CMGC_CDK2_HUMAN CMGC 6.9e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2IW6A P24941 1 295 298.0 QQ2:61296 Type1 Active DFGin 6.763 15.33 BLAminus -137.04, -179.89 52.44, 77.16 -90.65, 20.03 286.27, 71.9 -65.55, -20.57 in-in in 8.498 Saltbr-in 3.28 HRD-in -76.04, -56.62 74.08, 13.78 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.81, 140.32 APE9-dihe-na 81.92, 120.48 APE8-dihe-in -44.7, 124.8 APE8-rot-in 298.42 APE67-dihe-in -65.53, -21.14 -40.4, -43.63 APE12-dist-in 13.164 APE11-dist-in 10.454 APE10-dist-in 7.532 APE9-dist-in 3.387 K89T TPO160 TPO160 XRAY 2.3 0.231 0.287 A 302 292 3 0 0 0 [[4, 286]] 1.0 2iw6 Homo sapiens CMGC_CDK2_HUMAN CMGC 1.8e-89 306.4 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2IW6C P24941 1 295 298.0 QQ2:61296 Type1 Active DFGin 6.378 15.306 BLAminus -148.39, 175.51 55.38, 74.44 -89.04, 21.39 278.81, 70.78 -66.42, -21.32 in-in in 8.477 Saltbr-in 2.876 HRD-in -73.83, -61.91 76.25, 21.43 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.92, 136.02 APE9-dihe-na 64.76, 134.63 APE8-dihe-in -61.82, 140.99 APE8-rot-in 292.75 APE67-dihe-in -30.42, -30.52 -46.23, -72.37 APE12-dist-in 12.643 APE11-dist-in 9.835 APE10-dist-in 7.689 APE9-dist-in 3.426 K89T TPO160 TPO160 XRAY 2.3 0.231 0.287 C 302 295 0 0 0 0 [[4, 286]] 1.0 2iw6 Homo sapiens CMGC_CDK2_HUMAN CMGC 1.8e-89 306.4 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2IW9A P24941 1 297 298.0 4SP:61298 Type1 Active DFGin 6.92 15.019 BLAminus -131.25, 177.14 50.41, 78.45 -89.19, 19.11 279.3, 70.96 -63.04, -21.92 in-in in 8.627 Saltbr-in 2.664 HRD-in -76.84, -55.24 73.81, 13.13 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.48, 158.17 APE9-dihe-na 69.51, 127.63 APE8-dihe-in -55.41, 136.69 APE8-rot-in 292.83 APE67-dihe-in -55.29, -27.14 -47.71, -50.1 APE12-dist-in 13.103 APE11-dist-in 10.305 APE10-dist-in 7.154 APE9-dist-in 3.232 K89T TPO160 TPO160 XRAY 2.0 0.212 0.24 A 302 293 4 0 0 0 [[4, 286]] 1.0 2iw9 Homo sapiens CMGC_CDK2_HUMAN CMGC 1.8e-89 306.4 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2IW9C P24941 1 296 298.0 4SP:61297 Type1 Active DFGin 6.806 14.96 BLAminus -133.02, -178.76 46.09, 77.69 -88.26, 25.13 279.73, 69.06 -66.3, -29.69 in-in in 8.502 Saltbr-in 2.543 HRD-in -78.99, -52.42 69.26, 9.82 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.41, 143.8 APE9-dihe-na 66.28, 132.13 APE8-dihe-in -59.08, 144.46 APE8-rot-in 305.7 APE67-dihe-in -55.93, -27.46 -43.85, -53.77 APE12-dist-in 12.88 APE11-dist-in 9.931 APE10-dist-in 7.276 APE9-dist-in 3.2 K89T TPO160 TPO160 XRAY 2.0 0.212 0.24 C 302 268 28 0 0 0 [[4, 286]] 1.0 2iw9 Homo sapiens CMGC_CDK2_HUMAN CMGC 1.8e-89 306.4 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1E9HA P24941 1 296 298.0 INR:61298 Type1 Active DFGin 6.456 15.159 BLAminus -132.15, -179.42 51.68, 79.15 -95.02, 38.05 281.94, 68.75 -76.13, -20.19 in-in in 9.034 Saltbr-in 2.868 HRD-in -74.58, -48.32 61.21, 19.86 in-in-in SNCiii in-in ActLoopNT-in 3.102 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.15, 144.05 APE9-dihe-na 74.6, 131.04 APE8-dihe-in -55.94, 131.78 APE8-rot-in 296.32 APE67-dihe-in -63.26, -22.84 -39.36, -49.77 APE12-dist-in 12.88 APE11-dist-in 10.126 APE10-dist-in 7.306 APE9-dist-in 3.295 None TPO160 TPO160 XRAY 2.5 0.225 0.273 A 297 296 0 0 0 0 [[4, 286]] 1.0 1e9h Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1E9HC P24941 1 296 298.0 INR:61298 Type1 Active DFGin 6.187 14.816 BLAminus -143.02, -176.13 46.31, 80.97 -97.02, 27.76 290.87, 59.63 -66.56, -7.89 in-in in 8.729 Saltbr-in 3.159 HRD-in -83.98, -58.29 69.53, 16.91 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.56, 140.46 APE9-dihe-na 71.87, 130.47 APE8-dihe-in -59.96, 126.8 APE8-rot-in 308.14 APE67-dihe-in -42.57, -36.53 -26.81, -69.86 APE12-dist-in 12.735 APE11-dist-in 9.935 APE10-dist-in 7.407 APE9-dist-in 3.337 None TPO160 TPO160 XRAY 2.5 0.225 0.273 C 297 296 0 0 0 0 [[4, 286]] 1.0 1e9h Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PKDC P24941 1 296 298.0 UCN:60411 Type1 Active DFGin 6.463 15.32 BLAminus -135.87, 172.38 57.28, 84.68 -94.13, 24.13 279.18, 73.79 -65.7, -30.17 in-in in 8.633 Saltbr-in 3.481 HRD-in -72.06, -56.98 67.33, 21.98 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.36, 142.06 APE9-dihe-na 67.64, 128.7 APE8-dihe-in -51.48, 131.97 APE8-rot-in 292.97 APE67-dihe-in -55.98, -21.1 -45.12, -49.62 APE12-dist-in 12.786 APE11-dist-in 9.694 APE10-dist-in 7.51 APE9-dist-in 3.479 None TPO160 TPO160 XRAY 2.3 0.218 0.268 C 297 296 0 0 0 0 [[4, 286]] 1.0 1pkd Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9GLAA P24941 2 294 298.0 YNK:301 Type1 Active DFGin 6.577 15.514 BLAminus -128.21, 178.66 58.88, 75.5 -98.38, 16.76 279.06, 75.03 -64.26, -28.43 in-in in 8.711 Saltbr-in 3.598 HRD-in -78.33, -59.03 76.12, 9.43 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.31, 151.55 APE9-dihe-na 71.55, 133.57 APE8-dihe-in -59.31, 146.48 APE8-rot-in 291.51 APE67-dihe-in -64.58, -21.93 -51.88, -49.99 APE12-dist-in 13.01 APE11-dist-in 10.323 APE10-dist-in 7.256 APE9-dist-in 3.417 E8D,K9F,I10L,T14Q,Y15F,V64I,L83M,H84E,Q85T,K88E,K89V,Q131N TPO160 TPO160 XRAY 2.18 0.203 0.249 A 298 292 1 0 0 0 [[4, 286]] 1.0 9gla Homo sapiens CMGC_CDK2_HUMAN CMGC 8.4e-88 300.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C6TA P24941 1 296 298.0 DT5:1297 Type1 Active DFGin 6.799 15.352 BLAminus -134.06, 177.12 50.31, 82.89 -96.13, 18.51 277.35, 75.79 -53.62, -36.05 in-in in 8.861 Saltbr-in 2.999 HRD-in -80.9, -47.67 67.76, 13.99 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.31, 144.79 APE9-dihe-na 67.5, 141.86 APE8-dihe-in -68.03, 138.16 APE8-rot-in 289.35 APE67-dihe-in -64.46, -22.44 -44.45, -50.97 APE12-dist-in 13.024 APE11-dist-in 10.235 APE10-dist-in 7.508 APE9-dist-in 3.227 None TPO160 TPO160 XRAY 2.61 0.202 0.257 A 298 296 0 0 0 0 [[4, 286]] 1.0 2c6t Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C6TC P24941 1 296 298.0 DT5:1297 Type1 Active DFGin 6.657 15.404 BLAminus -131.57, -175.77 56.88, 80.2 -95.48, 27.17 280.99, 68.34 -80.53, -20.02 in-in in 8.739 Saltbr-in 2.887 HRD-in -82.32, -44.44 66.33, 11.16 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 146.11 APE9-dihe-na 67.63, 123.05 APE8-dihe-in -49.46, 128.41 APE8-rot-in 317.45 APE67-dihe-in -69.48, -17.34 -29.8, -51.85 APE12-dist-in 13.136 APE11-dist-in 10.777 APE10-dist-in 7.445 APE9-dist-in 3.325 None TPO160 TPO160 XRAY 2.61 0.202 0.257 C 298 296 0 0 0 0 [[4, 286]] 1.0 2c6t Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UZDA P24941 1 296 298.0 C85:1297 Type1 Active DFGin 6.451 14.85 BLAminus -133.11, 177.08 54.86, 85.28 -101.68, 20.96 284.06, 75.81 -61.27, -24.82 in-in in 8.444 Saltbr-in 3.177 HRD-in -83.73, -45.87 61.48, 6.66 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.42, 139.46 APE9-dihe-na 69.53, 135.24 APE8-dihe-in -61.62, 135.43 APE8-rot-in 303.68 APE67-dihe-in -58.15, -22.29 -39.06, -55.04 APE12-dist-in 13.102 APE11-dist-in 10.37 APE10-dist-in 7.796 APE9-dist-in 3.079 None TPO160 TPO160 XRAY 2.72 0.211 0.269 A 298 296 0 0 0 0 [[4, 286]] 1.0 2uzd Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UZDC P24941 1 296 298.0 C85:1297 Type1 Active DFGin 6.492 15.195 BLAminus -139.69, 179.82 41.45, 92.24 -104.15, 11.9 283.79, 67.43 -55.27, -17.29 in-in in 8.668 Saltbr-in 2.995 HRD-in -79.37, -45.87 62.75, 11.81 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.6, 143.72 APE9-dihe-na 77.42, 131.77 APE8-dihe-in -57.42, 123.98 APE8-rot-in 302.28 APE67-dihe-in -62.54, -19.9 -27.05, -62.32 APE12-dist-in 13.591 APE11-dist-in 11.063 APE10-dist-in 7.747 APE9-dist-in 3.361 None TPO160 TPO160 XRAY 2.72 0.211 0.269 C 298 296 0 0 0 0 [[4, 286]] 1.0 2uzd Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UZEA P24941 1 296 298.0 C95:1297 Type1 Active DFGin 6.754 15.05 BLAminus -135.91, 179.99 53.98, 78.89 -93.27, 19.08 281.96, 77.01 -61.65, -33.72 in-in in 8.583 Saltbr-in 2.498 HRD-in -73.47, -51.79 67.24, 9.7 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.88, 130.34 APE9-dihe-na 76.85, 131.74 APE8-dihe-in -52.05, 131.49 APE8-rot-in 297.06 APE67-dihe-in -66.18, -19.21 -44.9, -46.95 APE12-dist-in 13.145 APE11-dist-in 10.034 APE10-dist-in 7.852 APE9-dist-in 3.338 None TPO160 TPO160 XRAY 2.4 0.198 0.243 A 298 296 0 0 0 0 [[4, 286]] 1.0 2uze Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UZEC P24941 1 297 298.0 C95:1297 Type1 Active DFGin 6.667 14.941 BLAminus -135.15, 177.98 57.61, 75.33 -89.15, 22.31 284.49, 74.72 -59.82, -39.09 in-in in 8.537 Saltbr-in 2.571 HRD-in -68.46, -55.91 69.02, 11.45 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.35, 137.28 APE9-dihe-na 72.87, 131.3 APE8-dihe-in -52.65, 132.5 APE8-rot-in 295.51 APE67-dihe-in -60.05, -23.05 -45.59, -48.84 APE12-dist-in 13.108 APE11-dist-in 10.268 APE10-dist-in 7.788 APE9-dist-in 3.311 None TPO160 TPO160 XRAY 2.4 0.198 0.243 C 298 297 0 0 0 0 [[4, 286]] 1.0 2uze Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UZLA P24941 1 297 298.0 C94:1297 Type1 Active DFGin 6.674 15.097 BLAminus -137.35, -179.95 48.44, 89.21 -104.87, 15.72 282.26, 80.49 -52.99, -35.26 in-in in 8.495 Saltbr-in 2.864 HRD-in -68.42, -56.55 72.05, 13.65 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.42, 144.04 APE9-dihe-na 73.79, 126.12 APE8-dihe-in -49.7, 125.07 APE8-rot-in 292.94 APE67-dihe-in -62.68, -28.49 -39.21, -47.63 APE12-dist-in 13.086 APE11-dist-in 10.392 APE10-dist-in 7.376 APE9-dist-in 3.401 None TPO160 TPO160 XRAY 2.4 0.206 0.263 A 298 297 0 0 0 0 [[4, 286]] 1.0 2uzl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UZLC P24941 1 297 298.0 C94:1297 Type1 Active DFGin 6.73 15.087 BLAminus -136.39, 166.29 64.07, 80.46 -92.07, 24.97 289.04, 69.12 -64.82, -35.24 in-in in 8.423 Saltbr-in 3.088 HRD-in -65.05, -58.81 69.17, 21.46 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.18, 135.19 APE9-dihe-na 79.1, 130.79 APE8-dihe-in -54.78, 130.24 APE8-rot-in 295.69 APE67-dihe-in -60.88, -24.01 -43.31, -48.83 APE12-dist-in 13.04 APE11-dist-in 10.426 APE10-dist-in 7.65 APE9-dist-in 3.401 None TPO160 TPO160 XRAY 2.4 0.206 0.263 C 298 297 0 0 0 0 [[4, 286]] 1.0 2uzl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3EOCA P24941 1 298 298.0 T2A:501 Type1 Active DFGin 6.683 15.232 BLAminus -139.48, 178.88 46.72, 88.4 -103.11, 38.97 280.16, 70.52 -77.56, -25.26 in-in in 8.539 Saltbr-in 3.124 HRD-in -81.23, -48.84 74.21, -2.9 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.83, 16.33 APE9-dihe-na -79.39, 169.08 APE8-dihe-in -65.52, 148.54 APE8-rot-in 299.6 APE67-dihe-in -56.16, -33.34 -71.31, -51.77 APE12-dist-in 13.805 APE11-dist-in 11.384 APE10-dist-in 7.471 APE9-dist-in 4.447 None None None XRAY 3.2 0.216 0.238 A 298 295 3 0 0 0 [[4, 286]] 1.0 3eoc Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7KJSA P24941 1 297 298.0 WG1:60301 Type1 Active DFGin 6.941 15.435 BLAminus -129.35, 171.84 57.05, 81.38 -91.77, 23.58 280.88, 71.28 -66.78, -25.87 in-in in 8.757 Saltbr-in 2.752 HRD-in -76.08, -51.99 67.86, 12.12 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.51, -40.06 APE9-dihe-na -106.92, 150.6 APE8-dihe-in -55.34, 129.31 APE8-rot-in 282.03 APE67-dihe-in -59.24, -24.82 -35.92, -55.89 APE12-dist-in 13.361 APE11-dist-in 10.956 APE10-dist-in 7.62 APE9-dist-in 3.49 None TPO160 TPO160 XRAY 2.187 0.231 0.278 A 298 297 0 0 0 0 [[4, 286]] 1.0 7kjs Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9D0VA P24941 1 296 298.0 A1A1H:60301 Type1 Active DFGin 7.115 15.172 BLAminus -150.53, 171.22 54.29, 76.14 -85.06, 18.83 283.94, 69.83 -60.62, -21.05 in-in in 8.45 Saltbr-in 2.712 HRD-in -75.7, -55.17 69.28, 14.04 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.78, 157.01 APE9-dihe-na 74.81, 137.48 APE8-dihe-in -61.2, 139.24 APE8-rot-in 301.92 APE67-dihe-in -58.21, -20.25 -48.4, -45.12 APE12-dist-in 13.571 APE11-dist-in 11.879 APE10-dist-in 7.373 APE9-dist-in 3.117 None TPO160 TPO160 XRAY 2.54 0.193 0.231 A 298 296 0 0 0 0 [[4, 286]] 1.0 9d0v Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9GP3A P24941 1 298 298.0 A1IOP:60301 Type1 Active DFGin 6.91 15.356 BLAminus -140.68, 176.54 55.56, 75.28 -93.67, 27.79 286.84, 70.56 -62.0, -32.74 in-in in 8.702 Saltbr-in 3.325 HRD-in -68.03, -48.84 70.91, -9.67 in-in-in SNCiii in-in ActLoopNT-in 2.774 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.44, 166.25 APE9-dihe-na -2.05, 124.81 APE8-dihe-in -53.95, 116.42 APE8-rot-in 294.14 APE67-dihe-in -58.68, -30.68 -22.43, -40.64 APE12-dist-in 10.461 APE11-dist-in 9.942 APE10-dist-in 7.613 APE9-dist-in 3.897 None None None XRAY 2.45 0.235 0.273 A 298 298 0 0 0 0 [[4, 286]] 1.0 9gp3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8H6TA P24941 1 297 298.0 WZZ:60301 Type1 Active DFGin 6.882 15.455 BLAminus -134.73, 157.16 78.65, 78.35 -103.07, 24.14 283.51, 67.06 -62.14, -45.06 in-in in 8.839 Saltbr-in 3.098 HRD-in -67.48, -57.39 68.68, 6.96 in-in-in SNCiii in-in ActLoopNT-in 3.138 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.43, 172.0 APE9-dihe-na 67.71, 129.74 APE8-dihe-in -56.09, 140.94 APE8-rot-in 311.5 APE67-dihe-in -64.07, -35.96 -45.35, -50.45 APE12-dist-in 13.105 APE11-dist-in 11.361 APE10-dist-in 6.806 APE9-dist-in 3.265 None TPO160 TPO160 XRAY 3.0 0.254 0.358 A 298 297 0 0 0 0 [[4, 286]] 1.0 8h6t Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1P5EA P24941 1 296 298.0 TBS:60301 Type1 Active DFGin 6.66 15.009 BLAminus -134.09, 174.42 61.34, 86.25 -103.57, 17.59 277.72, 74.26 -59.56, -33.53 in-in in 8.446 Saltbr-in 2.674 HRD-in -77.23, -55.8 76.04, 12.25 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.42, 162.63 APE9-dihe-na 83.55, 127.96 APE8-dihe-in -48.61, 129.88 APE8-rot-in 295.62 APE67-dihe-in -60.38, -24.79 -44.17, -46.98 APE12-dist-in 13.307 APE11-dist-in 12.314 APE10-dist-in 7.439 APE9-dist-in 3.186 None TPO160 TPO160 XRAY 2.22 0.229 0.257 A 299 296 0 0 0 0 [[4, 286]] 1.0 1p5e Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1P5EC P24941 1 296 298.0 TBS:60302 Type1 Active DFGin 6.636 15.127 BLAminus -138.76, 179.25 54.43, 79.27 -94.7, 19.86 280.45, 76.08 -62.71, -27.5 in-in in 8.582 Saltbr-in 2.729 HRD-in -86.27, -53.86 71.16, 5.43 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -73.64, 170.31 APE9-dihe-na 70.48, 126.73 APE8-dihe-in -48.62, 130.16 APE8-rot-in 290.02 APE67-dihe-in -53.04, -25.69 -34.83, -58.58 APE12-dist-in 13.275 APE11-dist-in 12.466 APE10-dist-in 7.437 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.22 0.229 0.257 C 299 296 0 0 0 0 [[4, 286]] 1.0 1p5e Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2G9XA P24941 1 298 298.0 NU5:60299 Type1 Active DFGin 6.827 15.048 BLAminus -124.82, 176.56 48.86, 82.2 -91.6, 23.96 281.01, 67.28 -59.48, -35.09 in-in in 8.21 Saltbr-in 2.776 HRD-in -76.43, -52.2 71.68, 15.48 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.54, 143.11 APE9-dihe-na 70.21, 137.87 APE8-dihe-in -60.95, 139.73 APE8-rot-in 303.68 APE67-dihe-in -57.36, -16.12 -54.33, -48.28 APE12-dist-in 13.159 APE11-dist-in 10.467 APE10-dist-in 7.832 APE9-dist-in 3.165 None TPO160 TPO160 XRAY 2.5 0.219 0.265 A 299 298 0 0 0 0 [[4, 286]] 1.0 2g9x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2G9XC P24941 1 298 298.0 NU5:60299 Type1 Active DFGin 6.517 14.993 BLAminus -139.26, -169.73 32.06, 84.31 -85.43, 21.6 274.68, 73.33 -61.2, -32.43 in-in in 8.547 Saltbr-in 2.755 HRD-in -80.68, -48.96 66.6, 15.74 in-in-in SNCiii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.08, 144.68 APE9-dihe-na 74.92, 127.5 APE8-dihe-in -54.82, 137.89 APE8-rot-in 317.46 APE67-dihe-in -61.27, -22.51 -41.55, -53.55 APE12-dist-in 12.686 APE11-dist-in 10.089 APE10-dist-in 6.669 APE9-dist-in 3.319 None TPO160 TPO160 XRAY 2.5 0.219 0.265 C 299 274 24 0 0 0 [[4, 286]] 1.0 2g9x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3DDPA P24941 1 297 298.0 RC8:60299 Type1 Active DFGin 6.75 15.031 BLAminus -127.95, 179.43 46.52, 81.35 -92.16, 22.27 276.35, 73.24 -63.03, -31.46 in-in in 8.333 Saltbr-in 3.081 HRD-in -82.36, -50.36 62.52, 18.48 in-in-in SNCiii in-in ActLoopNT-in 3.023 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.09, 139.36 APE9-dihe-na 73.42, 128.44 APE8-dihe-in -50.13, 134.43 APE8-rot-in 283.7 APE67-dihe-in -56.68, -9.63 -42.52, -61.86 APE12-dist-in 13.006 APE11-dist-in 10.45 APE10-dist-in 7.666 APE9-dist-in 3.419 None TPO160 TPO160 XRAY 2.7 0.21 0.27 A 299 297 0 0 0 0 [[4, 286]] 1.0 3ddp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3DDPC P24941 1 298 298.0 RC8:60299 Type1 Active DFGin 6.62 14.862 BLAminus -118.86, 173.91 46.65, 94.24 -104.11, 18.75 283.31, 63.56 -50.59, -37.26 in-in in 8.255 Saltbr-in 3.128 HRD-in -82.76, -47.36 68.04, 19.59 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.71, 146.82 APE9-dihe-na 70.87, 140.11 APE8-dihe-in -54.32, 132.3 APE8-rot-in 319.96 APE67-dihe-in -62.39, -29.57 -44.26, -44.66 APE12-dist-in 13.205 APE11-dist-in 10.393 APE10-dist-in 7.453 APE9-dist-in 3.231 None TPO160 TPO160 XRAY 2.7 0.21 0.27 C 299 298 0 0 0 0 [[4, 286]] 1.0 3ddp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3DDQA P24941 1 298 298.0 RRC:60299 Type1 Active DFGin 6.88 15.378 BLAminus -132.75, 169.79 57.41, 82.03 -94.85, 22.97 280.61, 68.74 -62.61, -27.68 in-in in 8.717 Saltbr-in 2.631 HRD-in -76.69, -57.1 75.95, 10.79 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 66.92, 123.95 APE9-dihe-na 76.33, 127.94 APE8-dihe-in -56.03, 136.54 APE8-rot-in 295.57 APE67-dihe-in -61.4, -22.16 -47.57, -46.39 APE12-dist-in 13.299 APE11-dist-in 9.21 APE10-dist-in 7.386 APE9-dist-in 3.214 None TPO160 TPO160 XRAY 1.8 0.196 0.229 A 299 296 2 0 0 0 [[4, 286]] 1.0 3ddq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5L2WA P24941 1 297 298.0 1QK:60900 Type1 Active DFGin 6.854 15.309 BLAminus -124.76, 175.22 50.27, 87.67 -98.37, 21.86 279.74, 69.62 -63.43, -34.97 in-in in 8.137 Saltbr-in 2.806 HRD-in -75.13, -43.71 59.18, 15.83 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.49, -41.06 APE9-dihe-na -114.17, 152.38 APE8-dihe-in -52.38, 125.85 APE8-rot-in 308.7 APE67-dihe-in -64.98, -23.56 -37.65, -52.55 APE12-dist-in 13.072 APE11-dist-in 10.555 APE10-dist-in 7.457 APE9-dist-in 3.557 None TPO160 TPO160 XRAY 2.8 0.202 0.246 A 299 297 0 0 0 0 [[4, 286]] 1.0 5l2w Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5LMKA P24941 1 298 298.0 6ZK:60301 Type1 Active DFGin 6.747 15.226 BLAminus -137.46, 165.59 58.34, 86.4 -95.59, 20.68 280.82, 70.96 -57.68, -38.16 in-in in 8.451 Saltbr-in 2.802 HRD-in -76.51, -55.04 69.4, 17.32 in-in-in SNCiii in-in ActLoopNT-in 3.004 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -13.04, 141.69 APE9-dihe-na 70.85, 126.58 APE8-dihe-in -54.57, 132.69 APE8-rot-in 303.6 APE67-dihe-in -63.34, -26.66 -41.28, -45.6 APE12-dist-in 13.1 APE11-dist-in 9.802 APE10-dist-in 7.316 APE9-dist-in 3.345 None TPO160 TPO160 XRAY 2.4 0.213 0.249 A 299 296 2 0 0 0 [[4, 286]] 1.0 5lmk Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6GVAA P24941 1 290 298.0 FCQ:301 Type1 Active DFGin 6.724 15.119 BLAminus -143.33, 169.59 61.57, 78.81 -90.76, 25.85 282.82, 69.6 -66.77, -22.8 in-in in 8.35 Saltbr-in 2.678 HRD-in -78.76, -53.67 66.31, 18.04 in-in-in SNCiii in-in ActLoopNT-in 2.95 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.38, 150.36 APE9-dihe-na 78.29, 127.56 APE8-dihe-in -50.69, 137.83 APE8-rot-in 302.19 APE67-dihe-in -62.38, -24.48 -48.9, -48.16 APE12-dist-in 13.062 APE11-dist-in 10.417 APE10-dist-in 7.065 APE9-dist-in 3.217 None TPO160 TPO160 XRAY 2.15 0.197 0.24 A 299 288 2 0 0 0 [[4, 286]] 1.0 6gva Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6RIJA P24941 1 290 298.0 K4W:301 Type1 Active DFGin 6.77 15.201 BLAminus -137.79, 177.34 51.99, 79.82 -92.67, 18.49 283.09, 75.28 -64.02, -21.45 in-in in 8.325 Saltbr-in 2.755 HRD-in -78.15, -54.14 69.76, 19.75 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 154.76 APE9-dihe-na 67.96, 131.13 APE8-dihe-in -56.8, 139.72 APE8-rot-in 307.31 APE67-dihe-in -61.5, -26.7 -48.23, -49.61 APE12-dist-in 12.99 APE11-dist-in 10.148 APE10-dist-in 7.166 APE9-dist-in 3.299 None TPO160 TPO160 XRAY 2.2 0.205 0.238 A 299 290 0 0 0 0 [[4, 286]] 1.0 6rij Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6RIJC P24941 1 290 298.0 K4W:301 Type1 Active DFGin 6.623 15.158 BLAminus -139.42, 178.25 51.12, 80.38 -90.87, 16.64 283.29, 73.43 -59.1, -28.04 in-in in 8.346 Saltbr-in 2.736 HRD-in -78.29, -50.31 71.41, 9.22 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.98, 153.02 APE9-dihe-na 70.85, 130.87 APE8-dihe-in -56.89, 139.46 APE8-rot-in 304.34 APE67-dihe-in -59.76, -21.41 -50.49, -50.26 APE12-dist-in 13.027 APE11-dist-in 10.16 APE10-dist-in 7.091 APE9-dist-in 3.275 None TPO160 TPO160 XRAY 2.2 0.205 0.238 C 299 290 0 0 0 0 [[4, 286]] 1.0 6rij Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7ACKA P24941 1 294 298.0 R7B:60301 Type1 Active DFGin 6.6 15.093 BLAminus -137.07, 176.76 54.39, 79.26 -91.38, 21.84 284.28, 68.95 -64.22, -25.1 in-in in 8.363 Saltbr-in 2.815 HRD-in -78.41, -53.61 67.74, 12.29 in-in-in SNCiii in-in ActLoopNT-in 3.065 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.72, 155.75 APE9-dihe-na 71.06, 135.17 APE8-dihe-in -61.37, 135.3 APE8-rot-in 300.54 APE67-dihe-in -61.15, -26.3 -45.36, -47.78 APE12-dist-in 12.888 APE11-dist-in 10.064 APE10-dist-in 6.79 APE9-dist-in 3.167 None TPO160 TPO160 XRAY 1.8 0.197 0.232 A 299 294 0 0 0 0 [[4, 286]] 1.0 7ack Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7ACKC P24941 1 294 298.0 R7B:60301 Type1 Active DFGin 6.644 15.137 BLAminus -134.26, 175.58 54.35, 80.24 -91.1, 18.3 281.67, 67.12 -62.1, -23.73 in-in in 8.426 Saltbr-in 2.768 HRD-in -86.24, -55.68 72.18, 14.84 in-in-in SNCiii in-in ActLoopNT-in 3.037 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.93, 155.94 APE9-dihe-na 74.79, 129.29 APE8-dihe-in -59.07, 138.14 APE8-rot-in 303.31 APE67-dihe-in -58.22, -26.49 -46.93, -50.39 APE12-dist-in 12.846 APE11-dist-in 10.021 APE10-dist-in 6.74 APE9-dist-in 3.244 None TPO160 TPO160 XRAY 1.8 0.197 0.232 C 299 294 0 0 0 0 [[4, 286]] 1.0 7ack Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7B7SA P24941 1 293 298.0 T1T:301 Type1 Active DFGin 6.494 15.369 BLAminus -135.46, 168.92 55.58, 85.39 -99.09, 10.33 279.23, 76.96 -57.44, -26.5 in-in in 8.498 Saltbr-in 2.831 HRD-in -78.27, -59.79 70.57, 26.45 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.3, 147.4 APE9-dihe-na 74.12, 139.04 APE8-dihe-in -60.44, 136.44 APE8-rot-in 309.57 APE67-dihe-in -56.4, -24.99 -47.25, -49.3 APE12-dist-in 13.138 APE11-dist-in 10.151 APE10-dist-in 7.174 APE9-dist-in 3.316 None TPO160 TPO160 XRAY 2.54 0.248 0.291 A 299 287 6 0 0 0 [[4, 286]] 1.0 7b7s Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7B7SC P24941 1 293 298.0 T1T:301 Type1 Active DFGin 6.476 15.334 BLAminus -135.29, 165.88 63.39, 80.56 -102.81, 12.28 277.58, 80.14 -58.32, -27.1 in-in in 8.407 Saltbr-in 2.871 HRD-in -80.18, -52.79 63.94, 26.31 in-in-in SNCiii in-in ActLoopNT-in 2.838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.85, 151.36 APE9-dihe-na 75.44, 137.67 APE8-dihe-in -62.06, 135.14 APE8-rot-in 315.09 APE67-dihe-in -58.38, -25.42 -44.77, -50.87 APE12-dist-in 13.067 APE11-dist-in 10.398 APE10-dist-in 7.037 APE9-dist-in 3.337 None TPO160 TPO160 XRAY 2.54 0.248 0.291 C 299 288 5 0 0 0 [[4, 286]] 1.0 7b7s Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7QHLA P24941 1 294 298.0 D5P:301 Type1 Active DFGin 6.63 14.939 BLAminus -137.66, 172.33 61.28, 87.5 -99.75, 18.7 283.74, 70.1 -64.54, -23.39 in-in in 8.361 Saltbr-in 2.633 HRD-in -76.78, -58.13 72.67, 12.36 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.9, 152.57 APE9-dihe-na 70.74, 134.35 APE8-dihe-in -55.79, 134.07 APE8-rot-in 300.13 APE67-dihe-in -60.86, -25.16 -46.22, -50.21 APE12-dist-in 13.133 APE11-dist-in 10.364 APE10-dist-in 7.177 APE9-dist-in 3.252 None TPO160 TPO160 XRAY 1.7 0.2 0.224 A 299 285 9 0 0 0 [[4, 286]] 1.0 7qhl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7QHLC P24941 1 294 298.0 D5P:301 Type1 Active DFGin 6.623 14.889 BLAminus -137.6, 173.36 59.06, 89.06 -100.32, 17.76 284.01, 70.82 -62.33, -24.03 in-in in 8.302 Saltbr-in 2.687 HRD-in -77.9, -59.36 72.6, 14.8 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.03, 150.1 APE9-dihe-na 74.86, 133.85 APE8-dihe-in -55.13, 133.86 APE8-rot-in 302.35 APE67-dihe-in -60.96, -25.17 -45.08, -52.41 APE12-dist-in 13.085 APE11-dist-in 10.274 APE10-dist-in 7.137 APE9-dist-in 3.259 None TPO160 TPO160 XRAY 1.7 0.2 0.224 C 299 287 7 0 0 0 [[4, 286]] 1.0 7qhl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8B54C P24941 1 294 298.0 P2V:302 Type1 Active DFGin 6.514 15.099 BLAminus -122.54, 172.83 60.19, 84.09 -98.1, 19.4 281.6, 70.02 -54.41, -41.26 in-in in 8.374 Saltbr-in 2.81 HRD-in -75.35, -55.92 72.59, 17.93 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.35, 158.96 APE9-dihe-na 82.94, 134.61 APE8-dihe-in -57.65, 133.89 APE8-rot-in 307.69 APE67-dihe-in -50.27, -27.61 -42.77, -59.14 APE12-dist-in 13.319 APE11-dist-in 12.023 APE10-dist-in 7.065 APE9-dist-in 3.348 None TPO160 TPO160 XRAY 2.6 0.234 0.287 C 299 292 2 0 0 0 [[4, 286]] 1.0 8b54 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9BJCA P24941 1 296 298.0 A1AQZ:60301 Type1 Active DFGin 6.787 15.518 BLAminus -136.33, 173.64 59.65, 68.84 -84.15, 16.43 278.49, 68.94 -62.9, -29.29 in-in in 8.694 Saltbr-in 3.03 HRD-in -78.76, -53.42 71.16, 13.59 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.37, 170.37 APE9-dihe-na 67.43, 132.76 APE8-dihe-in -52.27, 139.93 APE8-rot-in 314.84 APE67-dihe-in -57.09, -23.14 -56.38, -42.51 APE12-dist-in 13.271 APE11-dist-in 11.643 APE10-dist-in 6.906 APE9-dist-in 3.112 None TPO160 TPO160 XRAY 2.22 0.195 0.213 A 299 296 0 0 0 0 [[4, 286]] 1.0 9bjc Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3BHTA P24941 1 298 298.0 MFR:60299 Type1 Active DFGin 6.726 14.916 BLAminus -135.33, 171.78 58.94, 90.09 -105.98, 17.26 279.11, 66.84 -57.88, -30.44 in-in in 8.524 Saltbr-in 2.721 HRD-in -76.97, -54.3 74.08, 10.3 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.38, 161.15 APE9-dihe-na 78.42, 133.04 APE8-dihe-in -54.1, 134.71 APE8-rot-in 298.86 APE67-dihe-in -59.06, -22.55 -47.47, -49.38 APE12-dist-in 13.275 APE11-dist-in 8.918 APE10-dist-in 7.502 APE9-dist-in 3.144 None TPO160 TPO160 XRAY 2.0 0.183 0.22 A 300 296 2 0 0 0 [[4, 286]] 1.0 3bht Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3BHTC P24941 1 296 298.0 MFR:60299 Type1 Active DFGin 6.648 14.904 BLAminus -135.56, 175.64 54.19, 83.05 -97.02, 23.87 283.3, 65.03 -60.61, -30.29 in-in in 8.364 Saltbr-in 2.63 HRD-in -78.59, -55.59 71.83, 12.5 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 49.0, 126.65 APE9-dihe-na 70.83, 124.33 APE8-dihe-in -53.09, 136.38 APE8-rot-in 313.14 APE67-dihe-in -65.14, -18.51 -41.66, -49.3 APE12-dist-in 12.892 APE11-dist-in 9.398 APE10-dist-in 7.12 APE9-dist-in 3.267 None TPO160 TPO160 XRAY 2.0 0.183 0.22 C 300 270 26 0 0 0 [[4, 286]] 1.0 3bht Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3BHUA P24941 1 298 298.0 MHR:60299 Type1 Active DFGin 6.786 14.752 BLAminus -134.75, 170.97 59.59, 89.97 -106.95, 20.16 283.64, 70.88 -60.21, -32.38 in-in in 8.351 Saltbr-in 2.647 HRD-in -76.05, -54.75 70.15, 15.56 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.89, 153.14 APE9-dihe-na 80.36, 131.09 APE8-dihe-in -55.87, 134.7 APE8-rot-in 300.34 APE67-dihe-in -60.91, -24.11 -43.0, -50.07 APE12-dist-in 13.226 APE11-dist-in 8.622 APE10-dist-in 7.792 APE9-dist-in 3.19 None TPO160 TPO160 XRAY 2.3 0.197 0.24 A 300 296 2 0 0 0 [[4, 286]] 1.0 3bhu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3BHVA P24941 1 298 298.0 VAR:60299 Type1 Active DFGin 6.749 15.036 BLAminus -132.56, 171.26 53.91, 86.13 -97.23, 18.97 284.34, 67.31 -58.53, -31.55 in-in in 8.469 Saltbr-in 2.954 HRD-in -79.43, -52.16 69.51, 13.01 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 2.04, 123.28 APE9-dihe-na 76.77, 132.03 APE8-dihe-in -52.21, 130.26 APE8-rot-in 301.0 APE67-dihe-in -61.5, -22.12 -41.07, -48.88 APE12-dist-in 13.177 APE11-dist-in 9.389 APE10-dist-in 7.5 APE9-dist-in 3.276 None TPO160 TPO160 XRAY 2.1 0.184 0.229 A 300 296 2 0 0 0 [[4, 286]] 1.0 3bhv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3BHVC P24941 1 296 298.0 VAR:60299 Type1 Active DFGin 6.717 15.117 BLAminus -131.34, 176.45 52.19, 85.58 -95.97, 17.71 279.3, 74.0 -62.28, -27.93 in-in in 8.469 Saltbr-in 2.832 HRD-in -77.61, -54.33 69.28, 11.28 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 34.08, 125.41 APE9-dihe-na 74.47, 123.34 APE8-dihe-in -47.68, 130.38 APE8-rot-in 303.56 APE67-dihe-in -62.09, -22.38 -41.46, -47.52 APE12-dist-in 12.813 APE11-dist-in 9.209 APE10-dist-in 7.16 APE9-dist-in 3.262 None TPO160 TPO160 XRAY 2.1 0.184 0.229 C 300 270 26 0 0 0 [[4, 286]] 1.0 3bhv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3MY5A P24941 1 298 298.0 RFZ:60300 Type1 Active DFGin 6.667 15.348 BLAminus -135.55, -178.04 53.6, 76.52 -97.01, 15.67 276.61, 75.78 -59.51, -26.48 in-in in 8.74 Saltbr-in 2.765 HRD-in -79.62, -51.44 67.18, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.67, 153.77 APE9-dihe-na 76.12, 127.46 APE8-dihe-in -56.8, 137.09 APE8-rot-in 303.01 APE67-dihe-in -62.09, -25.12 -50.14, -44.68 APE12-dist-in 13.142 APE11-dist-in 10.346 APE10-dist-in 7.108 APE9-dist-in 3.243 None TPO160 TPO160 XRAY 2.1 0.182 0.219 A 300 295 3 0 0 0 [[4, 286]] 1.0 3my5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3MY5C P24941 1 296 298.0 RFZ:60301 Type1 Active DFGin 6.72 15.383 BLAminus -140.83, -171.85 49.57, 71.36 -87.98, 20.89 279.16, 71.11 -63.16, -26.32 in-in in 8.599 Saltbr-in 2.699 HRD-in -80.11, -52.55 69.91, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.93, 151.21 APE9-dihe-na 70.99, 122.72 APE8-dihe-in -51.33, 141.26 APE8-rot-in 307.41 APE67-dihe-in -61.95, -24.04 -45.65, -48.3 APE12-dist-in 12.729 APE11-dist-in 9.812 APE10-dist-in 6.813 APE9-dist-in 3.261 None TPO160 TPO160 XRAY 2.1 0.182 0.219 C 300 266 30 0 0 0 [[4, 286]] 1.0 3my5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3TNWA P24941 1 298 298.0 F18:60299 Type1 Active DFGin 6.62 15.086 BLAminus -128.6, -178.26 47.86, 84.33 -97.78, 26.02 281.36, 66.37 -65.04, -21.33 in-in in 8.617 Saltbr-in 2.602 HRD-in -79.46, -53.41 71.4, 11.35 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.78, 148.35 APE9-dihe-na 78.36, 126.94 APE8-dihe-in -51.14, 135.98 APE8-rot-in 295.07 APE67-dihe-in -59.03, -26.11 -51.18, -45.17 APE12-dist-in 13.026 APE11-dist-in 10.012 APE10-dist-in 7.195 APE9-dist-in 3.205 None TPO160 TPO160 XRAY 2.0 0.188 0.227 A 300 295 3 0 0 0 [[4, 286]] 1.0 3tnw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3TNWC P24941 1 294 298.0 F18:60299 Type1 Active DFGin 6.338 14.965 BLAminus -134.92, -174.37 47.62, 80.87 -94.48, 22.71 276.99, 67.55 -61.56, -28.66 in-in in 8.678 Saltbr-in 2.953 HRD-in -84.06, -55.0 67.89, 14.76 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.7, 153.65 APE9-dihe-na 73.74, 131.99 APE8-dihe-in -62.58, 141.03 APE8-rot-in 293.51 APE67-dihe-in -61.78, -24.49 -48.04, -49.75 APE12-dist-in 12.955 APE11-dist-in 10.072 APE10-dist-in 6.987 APE9-dist-in 3.243 None TPO160 TPO160 XRAY 2.0 0.188 0.227 C 300 292 2 0 0 0 [[4, 286]] 1.0 3tnw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCKA P24941 1 297 298.0 T3E:61298 Type1 Active DFGin 6.708 16.138 BLAminus -140.99, 173.78 58.44, 83.6 -95.16, 19.86 283.39, 68.83 -69.82, -20.58 in-in in 9.421 Saltbr-in 2.873 HRD-in -80.61, -55.25 69.65, 13.56 in-in-in SNCiii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.97, 173.0 APE9-dihe-na 76.02, 130.96 APE8-dihe-in -51.63, 139.66 APE8-rot-in 300.99 APE67-dihe-in -63.31, -21.83 -54.68, -46.07 APE12-dist-in 13.796 APE11-dist-in 12.762 APE10-dist-in 7.712 APE9-dist-in 3.563 None TPO160 TPO160 XRAY 2.052 0.195 0.236 A 300 297 0 0 0 0 [[4, 286]] 1.0 4bck Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCKC P24941 1 294 298.0 T3E:61295 Type1 Active DFGin 6.713 16.1 BLAminus -148.76, 176.83 54.28, 81.47 -98.59, 19.66 274.57, 70.83 -77.07, -1.86 in-in in 9.422 Saltbr-in 3.113 HRD-in -81.61, -58.04 70.59, 16.83 in-in-in SNCiii in-in ActLoopNT-in 3.136 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.72, 152.92 APE9-dihe-na 73.06, 130.65 APE8-dihe-in -61.38, 138.76 APE8-rot-in 293.18 APE67-dihe-in -52.53, -29.03 -44.77, -57.29 APE12-dist-in 13.473 APE11-dist-in 10.45 APE10-dist-in 7.371 APE9-dist-in 3.513 None TPO160 TPO160 XRAY 2.052 0.195 0.236 C 300 292 2 0 0 0 [[4, 286]] 1.0 4bck Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCNA P24941 1 298 298.0 T9N:61299 Type1 Active DFGin 6.423 15.358 BLAminus -132.43, 173.08 59.42, 82.6 -96.18, 22.57 281.43, 68.76 -64.84, -22.05 in-in in 8.698 Saltbr-in 2.729 HRD-in -81.55, -53.36 72.5, 10.85 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.04, 151.85 APE9-dihe-na 74.21, 127.37 APE8-dihe-in -54.17, 135.78 APE8-rot-in 301.89 APE67-dihe-in -57.52, -26.56 -44.55, -50.59 APE12-dist-in 13.181 APE11-dist-in 10.34 APE10-dist-in 7.243 APE9-dist-in 3.172 None TPO160 TPO160 XRAY 2.1 0.186 0.219 A 300 296 2 0 0 0 [[4, 286]] 1.0 4bcn Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCNC P24941 1 294 298.0 T9N:61296 Type1 Active DFGin 6.348 15.366 BLAminus -138.9, 178.12 52.91, 85.38 -99.92, 21.79 276.63, 71.1 -66.78, -15.26 in-in in 8.773 Saltbr-in 2.693 HRD-in -81.41, -55.77 72.05, 12.07 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.57, 152.97 APE9-dihe-na 72.05, 129.38 APE8-dihe-in -57.95, 136.49 APE8-rot-in 299.74 APE67-dihe-in -57.16, -29.63 -40.31, -55.01 APE12-dist-in 13.049 APE11-dist-in 10.265 APE10-dist-in 7.088 APE9-dist-in 3.165 None TPO160 TPO160 XRAY 2.1 0.186 0.219 C 300 294 0 0 0 0 [[4, 286]] 1.0 4bcn Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCOA P24941 1 298 298.0 T6Q:61299 Type1 Active DFGin 6.474 15.117 BLAminus -135.79, 171.97 56.93, 82.69 -96.39, 24.73 280.25, 67.27 -60.9, -26.66 in-in in 8.492 Saltbr-in 2.643 HRD-in -81.64, -50.15 69.2, 12.85 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.17, 153.87 APE9-dihe-na 75.41, 126.9 APE8-dihe-in -55.82, 131.29 APE8-rot-in 296.78 APE67-dihe-in -57.59, -24.46 -39.45, -52.38 APE12-dist-in 13.008 APE11-dist-in 10.254 APE10-dist-in 7.069 APE9-dist-in 3.179 None TPO160 TPO160 XRAY 2.05 0.191 0.226 A 300 298 0 0 0 0 [[4, 286]] 1.0 4bco Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCOC P24941 1 296 298.0 T6Q:61298 Type1 Active DFGin 6.366 15.169 BLAminus -138.07, 175.97 55.78, 82.31 -98.44, 30.3 281.46, 70.87 -70.2, -23.66 in-in in 8.681 Saltbr-in 2.709 HRD-in -83.59, -54.01 73.46, 6.77 in-in-in SNCiii in-in ActLoopNT-in 3.01 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.63, 154.6 APE9-dihe-na 71.04, 127.33 APE8-dihe-in -59.71, 136.46 APE8-rot-in 300.15 APE67-dihe-in -53.39, -26.5 -38.01, -58.97 APE12-dist-in 12.803 APE11-dist-in 9.889 APE10-dist-in 6.916 APE9-dist-in 3.142 None TPO160 TPO160 XRAY 2.05 0.191 0.226 C 300 269 27 0 0 0 [[4, 286]] 1.0 4bco Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCPA P24941 1 298 298.0 T3C:61299 Type1 Active DFGin 6.533 15.191 BLAminus -134.13, 171.23 58.95, 82.45 -95.65, 26.87 280.18, 67.61 -65.02, -23.04 in-in in 8.481 Saltbr-in 2.732 HRD-in -79.81, -52.77 71.84, 11.29 in-in-in SNCiii in-in ActLoopNT-in 3.036 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.96, 155.67 APE9-dihe-na 72.11, 128.19 APE8-dihe-in -58.21, 133.91 APE8-rot-in 298.79 APE67-dihe-in -52.89, -28.0 -40.02, -53.78 APE12-dist-in 12.939 APE11-dist-in 10.283 APE10-dist-in 6.98 APE9-dist-in 3.128 None TPO160 TPO160 XRAY 2.26 0.183 0.217 A 300 298 0 0 0 0 [[4, 286]] 1.0 4bcp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCPC P24941 1 296 298.0 T3C:61297 Type1 Active DFGin 6.403 15.263 BLAminus -138.65, 173.95 55.78, 79.54 -94.55, 33.05 285.17, 67.29 -71.14, -20.19 in-in in 8.796 Saltbr-in 2.682 HRD-in -80.06, -56.76 72.61, 10.41 in-in-in SNCiii in-in ActLoopNT-in 3.065 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.86, 153.55 APE9-dihe-na 70.9, 126.48 APE8-dihe-in -52.55, 138.72 APE8-rot-in 308.97 APE67-dihe-in -53.33, -25.64 -40.93, -57.86 APE12-dist-in 12.705 APE11-dist-in 9.816 APE10-dist-in 6.736 APE9-dist-in 3.207 None TPO160 TPO160 XRAY 2.26 0.183 0.217 C 300 267 29 0 0 0 [[4, 286]] 1.0 4bcp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9OB2A P24941 1 298 298.0 A1CAE:301 Type1 Active DFGin 6.973 15.819 BLAminus -140.58, 171.08 58.52, 79.46 -94.8, 23.07 280.05, 75.23 -67.38, -31.52 in-in in 9.069 Saltbr-in 2.942 HRD-in -78.96, -52.8 68.26, 15.96 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.79, 173.58 APE9-dihe-na 68.76, 138.4 APE8-dihe-in -56.87, 148.48 APE8-rot-in 309.82 APE67-dihe-in -62.62, -24.47 -58.46, -45.68 APE12-dist-in 13.164 APE11-dist-in 12.165 APE10-dist-in 7.322 APE9-dist-in 3.24 None TPO160 TPO160 XRAY 2.12 0.222 0.254 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob2 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9OB3A P24941 1 298 298.0 A1CAH:301 Type1 Active DFGin 6.944 15.38 BLAminus -140.37, 165.75 61.33, 84.57 -97.71, 21.68 278.93, 69.47 -68.71, -23.45 in-in in 8.689 Saltbr-in 2.745 HRD-in -78.08, -52.73 68.36, 12.87 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.02, 171.78 APE9-dihe-na 72.31, 133.34 APE8-dihe-in -55.78, 146.1 APE8-rot-in 297.78 APE67-dihe-in -63.1, -23.49 -57.09, -47.96 APE12-dist-in 13.138 APE11-dist-in 12.222 APE10-dist-in 7.311 APE9-dist-in 3.233 None TPO160 TPO160 XRAY 1.98 0.22 0.244 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9OB4A P24941 1 298 298.0 A1CAF:301 Type1 Active DFGin 7.07 15.433 BLAminus -140.78, 171.16 58.81, 81.21 -94.48, 18.25 279.35, 70.51 -60.63, -24.89 in-in in 8.702 Saltbr-in 2.578 HRD-in -77.49, -52.8 70.85, 9.99 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.4, 171.78 APE9-dihe-na 71.79, 138.58 APE8-dihe-in -59.97, 144.28 APE8-rot-in 298.9 APE67-dihe-in -65.05, -23.77 -53.99, -47.04 APE12-dist-in 13.149 APE11-dist-in 12.232 APE10-dist-in 7.357 APE9-dist-in 3.261 None TPO160 TPO160 XRAY 1.95 0.211 0.251 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob4 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9OB5A P24941 1 298 298.0 A1CAG:301 Type1 Active DFGin 6.842 15.672 BLAminus -135.5, 170.11 58.28, 87.23 -101.1, 23.21 280.56, 72.89 -67.04, -29.15 in-in in 9.008 Saltbr-in 2.912 HRD-in -81.14, -52.75 70.15, 14.96 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.91, 175.18 APE9-dihe-na 68.51, 138.98 APE8-dihe-in -58.79, 149.16 APE8-rot-in 311.25 APE67-dihe-in -63.48, -24.66 -60.24, -43.57 APE12-dist-in 13.08 APE11-dist-in 12.166 APE10-dist-in 7.29 APE9-dist-in 3.272 None TPO160 TPO160 XRAY 2.1 0.234 0.255 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9OB6A P24941 1 298 298.0 A1CAI:301 Type1 Active DFGin 6.893 15.837 BLAminus -137.4, 170.01 57.92, 85.37 -99.98, 24.43 280.46, 72.7 -67.68, -29.62 in-in in 9.104 Saltbr-in 2.826 HRD-in -79.8, -52.56 69.42, 15.05 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -92.25, 173.7 APE9-dihe-na 68.67, 136.82 APE8-dihe-in -57.31, 149.69 APE8-rot-in 308.11 APE67-dihe-in -62.59, -22.53 -59.33, -46.2 APE12-dist-in 13.087 APE11-dist-in 12.103 APE10-dist-in 7.264 APE9-dist-in 3.249 None TPO160 TPO160 XRAY 2.0 0.228 0.256 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob6 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCMA P24941 1 296 298.0 T7Z:61297 Type1 Active DFGin 6.519 15.338 BLAminus -139.66, 174.2 58.72, 79.02 -93.6, 24.76 282.71, 70.29 -67.74, -29.26 in-in in 8.826 Saltbr-in 2.802 HRD-in -76.71, -53.42 71.43, 16.28 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.32, 150.29 APE9-dihe-na 79.09, 129.96 APE8-dihe-in -55.49, 136.02 APE8-rot-in 301.59 APE67-dihe-in -59.49, -23.97 -43.8, -51.06 APE12-dist-in 13.192 APE11-dist-in 10.409 APE10-dist-in 7.191 APE9-dist-in 3.251 None TPO160 TPO160 XRAY 2.45 0.198 0.258 A 301 293 3 0 0 0 [[4, 286]] 1.0 4bcm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCMC P24941 1 294 298.0 T7Z:61295 Type1 Active DFGin 6.195 15.206 BLAminus -144.88, 174.61 58.31, 79.88 -94.05, 24.48 286.22, 64.67 -52.96, -36.75 in-in in 8.929 Saltbr-in 2.868 HRD-in -78.72, -52.42 66.78, 17.05 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.18, 152.85 APE9-dihe-na 70.08, 132.37 APE8-dihe-in -63.98, 114.75 APE8-rot-in 298.59 APE67-dihe-in -41.3, -28.08 -11.16, -73.96 APE12-dist-in 13.079 APE11-dist-in 10.227 APE10-dist-in 7.136 APE9-dist-in 3.181 None TPO160 TPO160 XRAY 2.45 0.198 0.258 C 301 294 0 0 0 0 [[4, 286]] 1.0 4bcm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCQA P24941 1 295 298.0 TJF:61296 Type1 Active DFGin 6.591 15.979 BLAminus -145.97, 170.46 62.82, 84.99 -99.38, 29.59 282.23, 71.6 -71.19, -18.61 in-in in 9.404 Saltbr-in 3.453 HRD-in -85.05, -58.94 78.36, 12.61 in-in-in SNCiii in-in ActLoopNT-in 3.147 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.8, 176.97 APE9-dihe-na 69.33, 133.29 APE8-dihe-in -55.38, 139.69 APE8-rot-in 304.09 APE67-dihe-in -55.84, -22.0 -49.63, -50.65 APE12-dist-in 13.625 APE11-dist-in 12.543 APE10-dist-in 7.498 APE9-dist-in 3.511 None TPO160 TPO160 XRAY 2.4 0.217 0.252 A 301 290 5 0 0 0 [[4, 286]] 1.0 4bcq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BCQC P24941 1 294 298.0 TJF:61295 Type1 Active DFGin 6.54 16.003 BLAminus -147.36, 170.23 59.21, 86.27 -98.9, 28.16 278.44, 72.82 -71.37, -12.42 in-in in 9.598 Saltbr-in 3.261 HRD-in -88.13, -59.99 74.18, 19.51 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.48, 157.26 APE9-dihe-na 69.58, 129.95 APE8-dihe-in -57.66, 135.49 APE8-rot-in 301.27 APE67-dihe-in -62.84, -20.05 -48.44, -46.81 APE12-dist-in 13.54 APE11-dist-in 10.682 APE10-dist-in 7.689 APE9-dist-in 3.66 None TPO160 TPO160 XRAY 2.4 0.217 0.252 C 301 292 2 0 0 0 [[4, 286]] 1.0 4bcq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OGUA P24941 1 297 298.0 ST8:61298 Type1 Active DFGin 6.622 15.169 BLAminus -132.49, 178.72 58.24, 82.71 -102.92, 24.85 272.7, 69.89 -74.09, -24.68 in-in in 8.584 Saltbr-in 2.711 HRD-in -83.59, -50.74 65.24, 16.56 in-in-in SNCiii in-in ActLoopNT-in 2.822 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.85, 140.53 APE9-dihe-na 72.4, 128.48 APE8-dihe-in -54.32, 130.77 APE8-rot-in 295.27 APE67-dihe-in -62.29, -22.87 -28.24, -54.36 APE12-dist-in 13.216 APE11-dist-in 10.607 APE10-dist-in 7.764 APE9-dist-in 3.181 None TPO160 TPO160 XRAY 2.6 0.201 0.26 A 302 294 3 0 0 0 [[4, 286]] 1.0 1ogu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OGUC P24941 1 296 298.0 ST8:61297 Type1 Active DFGin 6.459 15.113 BLAminus -132.86, -172.42 44.38, 86.03 -97.68, 18.4 278.98, 66.1 -53.35, -25.74 in-in in 8.553 Saltbr-in 2.899 HRD-in -78.38, -50.69 67.57, 3.92 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.31, 136.82 APE9-dihe-na 72.62, 130.48 APE8-dihe-in -52.92, 126.38 APE8-rot-in 293.43 APE67-dihe-in -53.23, -26.2 -23.04, -62.3 APE12-dist-in 13.06 APE11-dist-in 10.203 APE10-dist-in 7.289 APE9-dist-in 3.21 None TPO160 TPO160 XRAY 2.6 0.201 0.26 C 302 270 26 0 0 0 [[4, 286]] 1.0 1ogu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OI9A P24941 1 296 298.0 N20:61298 Type1 Active DFGin 6.859 14.992 BLAminus -137.09, 176.73 49.35, 80.06 -92.0, 19.15 280.43, 70.88 -55.63, -24.85 in-in in 8.466 Saltbr-in 2.487 HRD-in -86.15, -51.32 70.37, 8.74 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.94, 147.34 APE9-dihe-na 76.84, 129.62 APE8-dihe-in -56.61, 135.02 APE8-rot-in 291.15 APE67-dihe-in -62.67, -21.75 -47.93, -44.41 APE12-dist-in 13.106 APE11-dist-in 10.324 APE10-dist-in 7.42 APE9-dist-in 3.152 None TPO160 TPO160 XRAY 2.1 0.233 0.276 A 302 295 1 0 0 0 [[4, 286]] 1.0 1oi9 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OI9C P24941 1 296 298.0 N20:61298 Type1 Active DFGin 6.633 14.824 BLAminus -152.07, 175.55 44.19, 85.97 -92.48, 17.16 278.61, 70.04 -60.62, -28.89 in-in in 8.502 Saltbr-in 2.546 HRD-in -78.68, -51.26 65.59, 16.91 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.76, 146.75 APE9-dihe-na 61.54, 130.0 APE8-dihe-in -61.63, 122.83 APE8-rot-in 314.38 APE67-dihe-in -56.62, -2.9 -14.2, -63.27 APE12-dist-in 12.796 APE11-dist-in 9.998 APE10-dist-in 7.209 APE9-dist-in 3.18 None TPO160 TPO160 XRAY 2.1 0.233 0.276 C 302 296 0 0 0 0 [[4, 286]] 1.0 1oi9 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OIUA P24941 1 297 298.0 N76:61298 Type1 Active DFGin 6.759 15.012 BLAminus -137.34, 178.77 51.55, 78.03 -91.83, 21.45 278.56, 70.28 -62.46, -30.57 in-in in 8.53 Saltbr-in 2.415 HRD-in -81.02, -53.81 70.44, 13.29 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.36, 148.76 APE9-dihe-na 73.2, 130.68 APE8-dihe-in -54.69, 132.3 APE8-rot-in 294.13 APE67-dihe-in -60.22, -23.68 -44.08, -49.04 APE12-dist-in 13.004 APE11-dist-in 10.218 APE10-dist-in 7.221 APE9-dist-in 3.127 None TPO160 TPO160 XRAY 2.0 0.216 0.253 A 302 294 3 0 0 0 [[4, 286]] 1.0 1oiu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OIUC P24941 1 296 298.0 N76:61298 Type1 Active DFGin 6.569 15.039 BLAminus -135.76, -176.9 45.26, 77.47 -86.34, 20.34 277.13, 73.62 -64.22, -25.41 in-in in 8.601 Saltbr-in 2.744 HRD-in -77.64, -55.36 70.75, 11.6 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.54, 139.18 APE9-dihe-na 71.75, 132.71 APE8-dihe-in -59.2, 139.16 APE8-rot-in 301.58 APE67-dihe-in -62.98, -21.95 -42.64, -49.62 APE12-dist-in 12.838 APE11-dist-in 9.801 APE10-dist-in 7.366 APE9-dist-in 3.178 None TPO160 TPO160 XRAY 2.0 0.216 0.253 C 302 265 31 0 0 0 [[4, 286]] 1.0 1oiu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OIYA P24941 1 296 298.0 N41:61298 Type1 Active DFGin 6.66 14.996 BLAminus -127.48, -178.66 52.26, 79.06 -92.28, 22.77 282.01, 74.59 -64.24, -22.66 in-in in 8.467 Saltbr-in 2.706 HRD-in -89.29, -51.55 80.68, 13.24 in-in-in SNCiii in-in ActLoopNT-in 2.769 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.42, 136.82 APE9-dihe-na 84.96, 128.45 APE8-dihe-in -46.78, 134.06 APE8-rot-in 292.24 APE67-dihe-in -64.62, -24.9 -49.77, -41.61 APE12-dist-in 13.259 APE11-dist-in 10.397 APE10-dist-in 7.764 APE9-dist-in 3.253 None TPO160 TPO160 XRAY 2.4 0.244 0.309 A 302 293 3 0 0 0 [[4, 286]] 1.0 1oiy Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OIYC P24941 1 296 298.0 N41:61298 Type1 Active DFGin 6.606 14.88 BLAminus -139.86, 175.08 52.38, 94.67 -103.32, 15.66 281.85, 70.39 -49.31, -37.57 in-in in 8.456 Saltbr-in 3.044 HRD-in -70.25, -62.2 71.8, 24.48 in-in-in SNCiii in-in ActLoopNT-in 2.694 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.13, 140.54 APE9-dihe-na 71.07, 126.83 APE8-dihe-in -55.12, 129.08 APE8-rot-in 283.04 APE67-dihe-in -48.74, -27.07 -21.27, -76.65 APE12-dist-in 13.043 APE11-dist-in 10.047 APE10-dist-in 7.374 APE9-dist-in 3.092 None TPO160 TPO160 XRAY 2.4 0.244 0.309 C 302 296 0 0 0 0 [[4, 286]] 1.0 1oiy Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFNA P24941 1 297 298.0 JYM:61298 Type1 Active DFGin 6.593 15.176 BLAminus -142.97, 176.43 52.3, 83.58 -94.67, 16.21 284.19, 69.15 -57.24, -25.79 in-in in 8.59 Saltbr-in 3.015 HRD-in -81.6, -56.87 73.91, 13.78 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.94, 143.63 APE9-dihe-na 73.87, 131.35 APE8-dihe-in -51.67, 139.86 APE8-rot-in 296.91 APE67-dihe-in -58.1, -27.15 -50.49, -50.55 APE12-dist-in 13.008 APE11-dist-in 10.344 APE10-dist-in 7.67 APE9-dist-in 3.207 None TPO160 TPO160 XRAY 2.2 0.199 0.241 A 302 294 3 0 0 0 [[4, 286]] 1.0 4cfn Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFNC P24941 1 294 298.0 JYM:61295 Type1 Active DFGin 6.426 14.837 BLAminus -142.53, 176.43 51.74, 85.66 -98.29, 18.68 281.06, 70.93 -56.1, -22.8 in-in in 8.483 Saltbr-in 3.031 HRD-in -82.46, -51.56 66.87, 14.45 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.99, 139.49 APE9-dihe-na 72.89, 132.9 APE8-dihe-in -53.97, 138.58 APE8-rot-in 296.44 APE67-dihe-in -57.72, -29.08 -49.72, -50.78 APE12-dist-in 13.064 APE11-dist-in 10.07 APE10-dist-in 7.803 APE9-dist-in 3.227 None TPO160 TPO160 XRAY 2.2 0.199 0.241 C 302 294 0 0 0 0 [[4, 286]] 1.0 4cfn Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6GUBA P24941 1 296 298.0 F9Z:60301 Type1 Active DFGin 6.574 14.893 BLAminus -133.39, -177.02 49.15, 84.77 -95.33, 26.44 284.0, 69.47 -66.54, -24.37 in-in in 8.932 Saltbr-in 2.781 HRD-in -82.81, -48.2 63.91, 17.46 in-in-in SNCiii in-in ActLoopNT-in 3.12 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.17, -71.28 APE9-dihe-na -85.68, 156.21 APE8-dihe-in -56.12, 137.27 APE8-rot-in 295.43 APE67-dihe-in -58.87, -25.5 -49.04, -50.47 APE12-dist-in 13.286 APE11-dist-in 10.474 APE10-dist-in 7.574 APE9-dist-in 3.498 None TPO160 TPO160 XRAY 2.52 0.198 0.238 A 302 293 3 0 0 0 [[4, 286]] 1.0 6gub Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6GUBC P24941 1 296 298.0 F9Z:60301 Type1 Active DFGin 6.543 15.025 BLAminus -133.23, -174.26 46.89, 85.25 -95.4, 27.01 280.96, 69.33 -67.09, -24.13 in-in in 8.886 Saltbr-in 2.766 HRD-in -82.92, -48.9 62.29, 18.94 in-in-in SNCiii in-in ActLoopNT-in 3.12 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.8, -72.83 APE9-dihe-na -86.19, 154.73 APE8-dihe-in -58.36, 138.73 APE8-rot-in 303.89 APE67-dihe-in -59.01, -27.57 -43.52, -51.38 APE12-dist-in 12.959 APE11-dist-in 10.553 APE10-dist-in 7.276 APE9-dist-in 3.553 None TPO160 TPO160 XRAY 2.52 0.198 0.238 C 302 291 5 0 0 0 [[4, 286]] 1.0 6gub Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6GUCA P24941 1 296 298.0 SU9:60301 Type1 Active DFGin 6.973 15.27 BLAminus -136.48, 168.46 59.83, 87.4 -95.55, 17.68 283.77, 73.7 -70.07, -21.28 in-in in 8.605 Saltbr-in 2.995 HRD-in -78.14, -56.76 74.58, 14.16 in-in-in SNCiii in-in ActLoopNT-in 3.077 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.08, 164.22 APE9-dihe-na 82.25, 131.29 APE8-dihe-in -49.82, 131.18 APE8-rot-in 295.31 APE67-dihe-in -63.1, -17.25 -48.27, -47.54 APE12-dist-in 13.479 APE11-dist-in 12.482 APE10-dist-in 7.719 APE9-dist-in 3.315 None TPO160 TPO160 XRAY 2.0 0.193 0.223 A 302 291 5 0 0 0 [[4, 286]] 1.0 6guc Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6GUCC P24941 1 296 298.0 SU9:60301 Type1 Active DFGin 6.908 15.265 BLAminus -133.88, 171.8 59.27, 85.55 -96.14, 18.38 283.75, 72.67 -65.8, -24.99 in-in in 8.617 Saltbr-in 2.943 HRD-in -77.5, -55.72 68.85, 17.91 in-in-in SNCiii in-in ActLoopNT-in 3.077 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.23, 146.05 APE9-dihe-na 73.9, 127.31 APE8-dihe-in -45.15, 131.88 APE8-rot-in 300.07 APE67-dihe-in -61.56, -19.13 -46.74, -49.91 APE12-dist-in 13.139 APE11-dist-in 10.3 APE10-dist-in 7.209 APE9-dist-in 3.388 None TPO160 TPO160 XRAY 2.0 0.193 0.223 C 302 296 0 0 0 0 [[4, 286]] 1.0 6guc Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6GUEC P24941 1 296 298.0 FB8:60301 Type1 Active DFGin 6.647 15.509 BLAminus -137.19, 176.14 51.03, 83.04 -90.71, 17.34 281.18, 72.33 -60.74, -26.78 in-in in 8.738 Saltbr-in 2.644 HRD-in -81.44, -55.33 72.3, 12.6 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -85.0, 169.8 APE9-dihe-na 75.79, 127.44 APE8-dihe-in -45.53, 131.47 APE8-rot-in 302.03 APE67-dihe-in -60.29, -20.12 -46.05, -47.88 APE12-dist-in 13.231 APE11-dist-in 12.427 APE10-dist-in 7.227 APE9-dist-in 3.327 None TPO160 TPO160 XRAY 1.99 0.198 0.234 C 302 288 8 0 0 0 [[4, 286]] 1.0 6gue Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6GUFA P24941 1 298 298.0 23D:60301 Type1 Active DFGin 6.774 15.293 BLAminus -136.48, -179.42 60.5, 81.44 -99.76, 28.15 284.82, 73.53 -62.92, -40.56 in-in in 8.646 Saltbr-in 3.324 HRD-in -59.96, -71.76 90.26, -6.29 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.04, 148.55 APE9-dihe-na 70.93, 137.33 APE8-dihe-in -58.72, 140.1 APE8-rot-in 293.64 APE67-dihe-in -64.27, -24.0 -45.62, -49.06 APE12-dist-in 13.023 APE11-dist-in 10.496 APE10-dist-in 7.369 APE9-dist-in 3.095 None TPO160 TPO160 XRAY 2.65 0.205 0.255 A 302 295 3 0 0 0 [[4, 286]] 1.0 6guf Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6GUFC P24941 1 297 298.0 23D:60301 Type1 Active DFGin 6.746 15.266 BLAminus -135.63, -175.55 48.4, 82.88 -93.3, 27.13 285.35, 72.61 -62.17, -42.75 in-in in 8.586 Saltbr-in 3.342 HRD-in -80.32, -45.78 56.89, 22.74 in-in-in SNCiii in-in ActLoopNT-in 3.123 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 39.73, -119.25 APE9-dihe-na -76.13, 148.61 APE8-dihe-in -55.68, 139.82 APE8-rot-in 314.94 APE67-dihe-in -62.54, -25.92 -42.68, -48.85 APE12-dist-in 12.677 APE11-dist-in 9.575 APE10-dist-in 7.221 APE9-dist-in 3.473 None TPO160 TPO160 XRAY 2.65 0.205 0.255 C 302 297 0 0 0 0 [[4, 286]] 1.0 6guf Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESNA P24941 1 294 298.0 UUS:60301 Type1 Active DFGin 6.648 15.165 BLAminus -134.79, 167.89 66.46, 85.3 -102.62, 30.84 284.71, 69.4 -77.75, -19.14 in-in in 8.633 Saltbr-in 3.078 HRD-in -81.61, -56.98 76.51, 12.0 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.95, 163.17 APE9-dihe-na 79.36, 120.08 APE8-dihe-in -44.61, 133.81 APE8-rot-in 298.13 APE67-dihe-in -63.84, -16.28 -49.11, -47.0 APE12-dist-in 12.918 APE11-dist-in 11.896 APE10-dist-in 7.116 APE9-dist-in 3.213 None TPO160 TPO160 XRAY 2.393 0.209 0.213 A 302 294 0 0 0 0 [[4, 286]] 1.0 9esn Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESPA P24941 1 289 298.0 UUV:61501 Type1 Active DFGin 6.606 15.358 BLAminus -132.48, 173.77 61.5, 85.32 -100.79, 26.42 280.93, 74.5 -68.1, -27.93 in-in in 8.731 Saltbr-in 3.142 HRD-in -80.19, -56.19 71.67, 19.17 in-in-in SNCiii in-in ActLoopNT-in 3.106 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.09, 167.9 APE9-dihe-na 77.78, 132.7 APE8-dihe-in -56.52, 135.5 APE8-rot-in 293.34 APE67-dihe-in -59.37, -23.33 -49.92, -46.56 APE12-dist-in 13.039 APE11-dist-in 12.06 APE10-dist-in 7.239 APE9-dist-in 3.277 None TPO160 TPO160 XRAY 2.381 0.209 0.212 A 302 289 0 0 0 0 [[4, 286]] 1.0 9esp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESPC P24941 1 296 298.0 UUV:60501 Type1 Active DFGin 6.645 15.343 BLAminus -131.05, -177.65 50.95, 84.02 -94.43, 20.18 280.44, 67.59 -56.35, -37.01 in-in in 8.49 Saltbr-in 2.8 HRD-in -80.67, -58.91 74.42, 12.98 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 143.12 APE9-dihe-na 80.05, 122.59 APE8-dihe-in -48.25, 143.39 APE8-rot-in 304.08 APE67-dihe-in -52.08, -27.79 -51.89, -53.35 APE12-dist-in 12.874 APE11-dist-in 10.055 APE10-dist-in 7.025 APE9-dist-in 3.174 None TPO160 TPO160 XRAY 2.381 0.209 0.212 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESUA P24941 1 298 298.0 IJU:60301 Type1 Active DFGin 6.597 15.228 BLAminus -137.02, 172.06 60.5, 86.03 -101.36, 24.49 279.2, 77.34 -65.25, -31.27 in-in in 8.578 Saltbr-in 3.151 HRD-in -78.61, -60.05 78.55, 19.06 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.89, 166.29 APE9-dihe-na 79.38, 125.96 APE8-dihe-in -52.45, 138.06 APE8-rot-in 299.33 APE67-dihe-in -63.0, -18.82 -55.53, -44.62 APE12-dist-in 13.012 APE11-dist-in 12.27 APE10-dist-in 7.226 APE9-dist-in 3.325 None TPO160 TPO160 XRAY 2.396 0.214 0.216 A 302 298 0 0 0 0 [[4, 286]] 1.0 9esu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESUC P24941 1 296 298.0 IJU:60301 Type1 Active DFGin 6.756 15.221 BLAminus -141.36, -172.39 47.3, 82.34 -98.62, 30.36 281.12, 66.06 -78.12, -24.78 in-in in 8.502 Saltbr-in 2.861 HRD-in -86.11, -54.93 71.99, 13.31 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.41, 141.48 APE9-dihe-na 77.5, 127.54 APE8-dihe-in -56.29, 139.63 APE8-rot-in 297.98 APE67-dihe-in -53.31, -27.07 -43.94, -55.69 APE12-dist-in 12.83 APE11-dist-in 10.434 APE10-dist-in 7.185 APE9-dist-in 3.27 None TPO160 TPO160 XRAY 2.396 0.214 0.216 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESXC P24941 1 296 298.0 A1H6Y:60501 Type1 Active DFGin 6.602 15.39 BLAminus -133.13, -177.79 55.96, 73.53 -88.35, 23.36 279.9, 72.69 -58.54, -31.38 in-in in 8.493 Saltbr-in 2.833 HRD-in -85.21, -57.78 75.56, 8.81 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.16, 150.53 APE9-dihe-na 72.07, 129.83 APE8-dihe-in -57.83, 139.49 APE8-rot-in 297.9 APE67-dihe-in -56.08, -27.9 -42.98, -54.66 APE12-dist-in 12.745 APE11-dist-in 10.117 APE10-dist-in 6.852 APE9-dist-in 3.222 None TPO160 TPO160 XRAY 2.37 0.222 0.229 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esx Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESYC P24941 1 296 298.0 HH8:60601 Type1 Active DFGin 6.815 15.392 BLAminus -143.51, -171.61 48.8, 76.72 -98.69, 31.73 280.0, 78.65 -75.94, -27.79 in-in in 8.704 Saltbr-in 2.739 HRD-in -81.36, -63.29 73.99, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.04, 152.88 APE9-dihe-na 70.43, 129.81 APE8-dihe-in -56.88, 139.73 APE8-rot-in 314.35 APE67-dihe-in -55.17, -26.22 -41.74, -56.57 APE12-dist-in 12.652 APE11-dist-in 9.842 APE10-dist-in 6.698 APE9-dist-in 3.152 None TPO160 TPO160 XRAY 2.394 0.257 0.262 C 302 265 31 0 0 0 [[4, 286]] 1.0 9esy Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESZA P24941 1 292 298.0 HGW:60601 Type1 Active DFGin 6.578 15.332 BLAminus -132.04, 171.04 63.6, 85.87 -98.66, 25.0 277.0, 76.47 -70.53, -27.06 in-in in 8.642 Saltbr-in 3.001 HRD-in -80.25, -60.98 81.99, 14.7 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -71.52, 168.74 APE9-dihe-na 75.8, 128.24 APE8-dihe-in -49.62, 139.46 APE8-rot-in 302.85 APE67-dihe-in -59.69, -19.57 -54.76, -48.33 APE12-dist-in 13.123 APE11-dist-in 12.077 APE10-dist-in 7.086 APE9-dist-in 3.248 None TPO160 TPO160 XRAY 2.42 0.212 0.213 A 302 292 0 0 0 0 [[4, 286]] 1.0 9esz Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESZC P24941 1 296 298.0 HGW:60501 Type1 Active DFGin 6.699 15.376 BLAminus -138.8, -176.72 49.7, 80.72 -92.52, 24.31 277.61, 74.75 -64.18, -24.0 in-in in 8.456 Saltbr-in 2.966 HRD-in -81.04, -55.78 70.54, 14.46 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.11, 146.25 APE9-dihe-na 77.04, 123.95 APE8-dihe-in -50.26, 136.24 APE8-rot-in 297.63 APE67-dihe-in -54.0, -25.83 -45.3, -55.89 APE12-dist-in 13.031 APE11-dist-in 10.458 APE10-dist-in 7.148 APE9-dist-in 3.25 None TPO160 TPO160 XRAY 2.42 0.212 0.213 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esz Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET0A P24941 1 298 298.0 HHN:60301 Type1 Active DFGin 6.638 15.241 BLAminus -134.9, 175.1 57.37, 82.81 -94.18, 18.73 280.11, 75.28 -62.18, -27.41 in-in in 8.716 Saltbr-in 3.021 HRD-in -79.22, -60.59 80.44, 14.72 in-in-in SNCiii in-in ActLoopNT-in 2.986 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -60.34, 170.44 APE9-dihe-na 75.62, 129.42 APE8-dihe-in -52.98, 137.89 APE8-rot-in 301.96 APE67-dihe-in -61.35, -20.22 -51.89, -49.35 APE12-dist-in 13.112 APE11-dist-in 11.998 APE10-dist-in 7.119 APE9-dist-in 3.243 None TPO160 TPO160 XRAY 2.239 0.235 0.239 A 302 298 0 0 0 0 [[4, 286]] 1.0 9et0 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET0C P24941 1 296 298.0 HHN:60301 Type1 Active DFGin 6.733 15.638 BLAminus -141.22, -178.98 56.42, 68.49 -82.49, 27.84 282.91, 72.01 -73.64, -20.97 in-in in 8.622 Saltbr-in 2.747 HRD-in -80.75, -59.23 74.38, 11.19 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.37, 152.48 APE9-dihe-na 75.08, 131.84 APE8-dihe-in -56.51, 137.62 APE8-rot-in 304.65 APE67-dihe-in -57.06, -22.75 -41.43, -52.94 APE12-dist-in 12.838 APE11-dist-in 10.435 APE10-dist-in 6.838 APE9-dist-in 3.172 None TPO160 TPO160 XRAY 2.239 0.235 0.239 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et0 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET1C P24941 1 296 298.0 IJL:60301 Type1 Active DFGin 6.623 15.492 BLAminus -135.39, -177.33 51.33, 83.18 -94.5, 20.01 273.11, 76.66 -59.44, -32.33 in-in in 8.593 Saltbr-in 2.876 HRD-in -83.75, -57.91 76.36, 7.46 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.5, 147.34 APE9-dihe-na 76.93, 124.91 APE8-dihe-in -54.11, 139.39 APE8-rot-in 309.88 APE67-dihe-in -59.67, -21.6 -42.38, -52.57 APE12-dist-in 12.846 APE11-dist-in 10.096 APE10-dist-in 7.185 APE9-dist-in 3.216 None TPO160 TPO160 XRAY 2.394 0.221 0.228 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET2C P24941 1 296 298.0 IJX:60501 Type1 Active DFGin 6.584 15.27 BLAminus -138.1, -174.28 43.8, 86.79 -97.27, 25.78 280.09, 73.01 -64.15, -26.09 in-in in 8.412 Saltbr-in 2.806 HRD-in -80.71, -60.66 80.25, 0.88 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.46, 149.88 APE9-dihe-na 78.61, 126.17 APE8-dihe-in -51.98, 138.05 APE8-rot-in 306.97 APE67-dihe-in -57.75, -25.38 -42.91, -53.12 APE12-dist-in 12.912 APE11-dist-in 10.439 APE10-dist-in 6.89 APE9-dist-in 3.092 None TPO160 TPO160 XRAY 2.37 0.229 0.231 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et2 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET7C P24941 1 296 298.0 HGQ:60301 Type1 Active DFGin 6.628 15.492 BLAminus -134.87, 177.99 57.6, 75.53 -90.81, 23.9 281.22, 72.55 -65.86, -32.54 in-in in 8.641 Saltbr-in 3.015 HRD-in -77.38, -56.31 71.77, 14.03 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.83, 150.81 APE9-dihe-na 73.21, 128.16 APE8-dihe-in -54.48, 138.37 APE8-rot-in 306.51 APE67-dihe-in -58.88, -21.95 -48.81, -49.4 APE12-dist-in 12.875 APE11-dist-in 10.351 APE10-dist-in 7.064 APE9-dist-in 3.362 None TPO160 TPO160 XRAY 2.312 0.241 0.271 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et7 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ETAA P24941 1 298 298.0 7ZX:60601 Type1 Active DFGin 6.843 15.39 BLAminus -130.87, 177.54 61.19, 88.41 -108.49, 29.69 278.15, 78.57 -76.9, -23.03 in-in in 8.704 Saltbr-in 3.381 HRD-in -80.89, -60.33 80.32, 14.58 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.1, 157.98 APE9-dihe-na 80.83, 121.24 APE8-dihe-in -46.09, 138.61 APE8-rot-in 304.51 APE67-dihe-in -61.54, -19.39 -60.41, -43.93 APE12-dist-in 13.081 APE11-dist-in 11.907 APE10-dist-in 7.224 APE9-dist-in 3.18 None TPO160 TPO160 XRAY 2.512 0.22 0.24 A 302 298 0 0 0 0 [[4, 286]] 1.0 9eta Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ETAC P24941 1 296 298.0 7ZX:60301 Type1 Active DFGin 6.608 15.586 BLAminus -137.08, 177.84 55.91, 77.1 -88.51, 26.15 277.04, 73.55 -60.47, -35.41 in-in in 8.739 Saltbr-in 2.914 HRD-in -81.68, -51.59 67.1, 13.15 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.15, 148.64 APE9-dihe-na 70.71, 128.57 APE8-dihe-in -53.3, 142.24 APE8-rot-in 310.82 APE67-dihe-in -59.33, -28.84 -51.21, -47.8 APE12-dist-in 13.08 APE11-dist-in 10.731 APE10-dist-in 7.013 APE9-dist-in 3.3 None TPO160 TPO160 XRAY 2.512 0.22 0.24 C 302 296 0 0 0 0 [[4, 286]] 1.0 9eta Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H1PA P24941 1 296 298.0 CMG:61298 Type1 Active DFGin 6.499 15.117 BLAminus -138.92, -178.75 49.09, 86.95 -98.56, 13.99 278.53, 73.35 -55.78, -28.79 in-in in 8.454 Saltbr-in 2.721 HRD-in -77.48, -54.23 72.33, 13.84 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.77, 156.24 APE9-dihe-na 69.07, 128.03 APE8-dihe-in -49.71, 132.1 APE8-rot-in 291.9 APE67-dihe-in -61.95, -27.18 -48.08, -36.47 APE12-dist-in 13.052 APE11-dist-in 10.052 APE10-dist-in 7.235 APE9-dist-in 3.162 None TPO160 TPO160 XRAY 2.1 0.222 0.258 A 303 296 0 0 0 0 [[4, 286]] 1.0 1h1p Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H1PC P24941 1 296 298.0 CMG:61298 Type1 Active DFGin 6.566 15.153 BLAminus -139.68, 176.89 52.0, 85.54 -98.31, 22.42 285.04, 73.37 -70.33, -22.32 in-in in 8.589 Saltbr-in 2.781 HRD-in -79.75, -57.12 71.34, 16.79 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.98, 156.69 APE9-dihe-na 68.49, 129.02 APE8-dihe-in -58.75, 132.04 APE8-rot-in 288.32 APE67-dihe-in -70.71, -22.16 -48.03, -37.61 APE12-dist-in 12.877 APE11-dist-in 9.888 APE10-dist-in 7.254 APE9-dist-in 3.241 None TPO160 TPO160 XRAY 2.1 0.222 0.258 C 303 296 0 0 0 0 [[4, 286]] 1.0 1h1p Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H1QC P24941 1 296 298.0 2A6:61298 Type1 Active DFGin 6.238 14.7 BLAminus -137.56, 168.0 63.76, 81.0 -88.76, 14.52 280.77, 71.51 -57.63, -25.21 in-in in 8.403 Saltbr-in 2.986 HRD-in -87.0, -45.2 67.54, 31.89 in-in-in SNCiii in-in ActLoopNT-in 2.778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.07, 157.24 APE9-dihe-na 53.6, 133.67 APE8-dihe-in -53.3, 139.53 APE8-rot-in 282.96 APE67-dihe-in -62.62, -13.03 -52.36, -46.94 APE12-dist-in 12.909 APE11-dist-in 10.223 APE10-dist-in 7.579 APE9-dist-in 3.209 None TPO160 TPO160 XRAY 2.5 0.238 0.332 C 303 296 0 0 0 0 [[4, 286]] 1.0 1h1q Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H1RA P24941 1 296 298.0 6CP:61298 Type1 Active DFGin 6.778 15.045 BLAminus -141.23, 176.27 52.5, 80.35 -92.59, 20.98 276.21, 73.58 -61.73, -20.62 in-in in 8.611 Saltbr-in 2.618 HRD-in -81.53, -52.36 73.7, 8.7 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.38, 147.29 APE9-dihe-na 77.95, 127.28 APE8-dihe-in -54.9, 142.91 APE8-rot-in 298.86 APE67-dihe-in -65.2, -19.39 -52.85, -42.63 APE12-dist-in 13.037 APE11-dist-in 10.006 APE10-dist-in 7.64 APE9-dist-in 3.218 None TPO160 TPO160 XRAY 2.0 0.235 0.294 A 303 296 0 0 0 0 [[4, 286]] 1.0 1h1r Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H1RC P24941 1 296 298.0 6CP:61298 Type1 Active DFGin 6.553 14.842 BLAminus -148.02, -175.89 41.5, 81.22 -90.01, 20.08 282.78, 67.07 -58.8, -29.6 in-in in 8.628 Saltbr-in 2.435 HRD-in -79.05, -61.01 72.22, 16.79 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.3, 151.09 APE9-dihe-na 62.76, 123.0 APE8-dihe-in -43.65, 134.07 APE8-rot-in 300.23 APE67-dihe-in -54.33, -21.74 -47.48, -55.72 APE12-dist-in 12.822 APE11-dist-in 9.742 APE10-dist-in 7.312 APE9-dist-in 3.321 None TPO160 TPO160 XRAY 2.0 0.235 0.294 C 303 296 0 0 0 0 [[4, 286]] 1.0 1h1r Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H1SA P24941 1 296 298.0 4SP:61298 Type1 Active DFGin 6.771 14.88 BLAminus -138.27, 176.48 54.47, 75.94 -86.39, 16.38 279.91, 75.66 -60.96, -21.57 in-in in 8.523 Saltbr-in 2.546 HRD-in -82.14, -48.27 62.29, 17.28 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.1, 148.9 APE9-dihe-na 77.73, 132.64 APE8-dihe-in -56.46, 146.46 APE8-rot-in 297.88 APE67-dihe-in -62.68, -22.66 -55.95, -45.74 APE12-dist-in 13.041 APE11-dist-in 10.252 APE10-dist-in 7.488 APE9-dist-in 3.216 None TPO160 TPO160 XRAY 2.0 0.236 0.286 A 303 296 0 0 0 0 [[4, 286]] 1.0 1h1s Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H1SC P24941 1 296 298.0 4SP:61298 Type1 Active DFGin 6.574 15.065 BLAminus -139.76, -179.38 46.77, 76.48 -88.51, 14.99 275.39, 74.13 -49.48, -23.18 in-in in 8.909 Saltbr-in 2.634 HRD-in -75.61, -51.23 64.22, 19.85 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.84, 146.42 APE9-dihe-na 78.4, 136.91 APE8-dihe-in -69.97, 138.51 APE8-rot-in 287.12 APE67-dihe-in -55.51, -31.94 -44.12, -51.67 APE12-dist-in 13.078 APE11-dist-in 10.307 APE10-dist-in 7.331 APE9-dist-in 3.176 None TPO160 TPO160 XRAY 2.0 0.236 0.286 C 303 296 0 0 0 0 [[4, 286]] 1.0 1h1s Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFMA P24941 1 296 298.0 4QE:61297 Type1 Active DFGin 6.388 15.294 BLAminus -138.86, -176.13 51.5, 75.94 -84.71, 19.18 282.42, 65.54 -49.76, -36.4 in-in in 8.548 Saltbr-in 2.661 HRD-in -81.16, -48.5 61.38, 12.94 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.25, 140.44 APE9-dihe-na 73.77, 137.41 APE8-dihe-in -62.76, 142.45 APE8-rot-in 324.66 APE67-dihe-in -57.36, -23.49 -43.84, -57.99 APE12-dist-in 12.853 APE11-dist-in 10.405 APE10-dist-in 7.512 APE9-dist-in 3.169 None TPO160 TPO160 XRAY 2.85 0.219 0.258 A 303 296 0 0 0 0 [[4, 286]] 1.0 4cfm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFMC P24941 1 296 298.0 4QE:61297 Type1 Active DFGin 6.221 15.189 BLAminus -142.93, -178.85 51.13, 76.15 -84.23, 19.76 283.72, 70.42 -51.95, -31.37 in-in in 8.353 Saltbr-in 2.625 HRD-in -79.93, -49.37 65.61, 16.12 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.92, 141.62 APE9-dihe-na 71.18, 140.32 APE8-dihe-in -65.45, 140.0 APE8-rot-in 314.14 APE67-dihe-in -54.47, -25.31 -33.87, -64.74 APE12-dist-in 12.864 APE11-dist-in 10.339 APE10-dist-in 7.301 APE9-dist-in 3.206 None TPO160 TPO160 XRAY 2.85 0.219 0.258 C 303 266 30 0 0 0 [[4, 286]] 1.0 4cfm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFWA P24941 1 298 298.0 SQ9:61299 Type1 Active DFGin 6.75 15.485 BLAminus -136.96, -173.97 45.59, 77.09 -83.58, 21.25 281.72, 72.41 -61.45, -31.18 in-in in 8.97 Saltbr-in 2.774 HRD-in -80.37, -54.45 72.08, 16.81 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.22, 147.94 APE9-dihe-na 77.59, 131.51 APE8-dihe-in -59.06, 146.89 APE8-rot-in 296.38 APE67-dihe-in -59.52, -23.68 -54.1, -46.67 APE12-dist-in 13.008 APE11-dist-in 10.199 APE10-dist-in 7.122 APE9-dist-in 3.321 None TPO160 TPO160 XRAY 2.45 0.188 0.241 A 303 298 0 0 0 0 [[4, 286]] 1.0 4cfw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFWC P24941 1 296 298.0 SQ9:61297 Type1 Active DFGin 6.736 15.424 BLAminus -141.99, -176.48 44.07, 78.18 -86.53, 15.76 283.21, 70.66 -50.68, -33.08 in-in in 8.919 Saltbr-in 2.804 HRD-in -80.65, -49.07 61.58, 17.73 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.23, 149.27 APE9-dihe-na 77.75, 130.41 APE8-dihe-in -57.97, 143.53 APE8-rot-in 298.16 APE67-dihe-in -59.74, -25.8 -48.23, -50.27 APE12-dist-in 13.098 APE11-dist-in 10.272 APE10-dist-in 7.093 APE9-dist-in 3.314 None TPO160 TPO160 XRAY 2.45 0.188 0.241 C 303 296 0 0 0 0 [[4, 286]] 1.0 4cfw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFXA P24941 1 298 298.0 G6T:61299 Type1 Active DFGin 6.601 15.153 BLAminus -137.97, 169.05 56.34, 77.85 -94.42, 27.07 283.56, 72.41 -55.94, -34.34 in-in in 8.739 Saltbr-in 3.413 HRD-in -80.0, -48.77 67.93, 12.9 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.93, 133.26 APE9-dihe-na -134.31, -168.88 APE8-dihe-in -52.68, 136.23 APE8-rot-in 289.49 APE67-dihe-in -51.99, -24.9 -51.69, -52.0 APE12-dist-in 13.144 APE11-dist-in 10.601 APE10-dist-in 7.605 APE9-dist-in 3.485 None TPO160 TPO160 XRAY 3.5 0.207 0.269 A 303 298 0 0 0 0 [[4, 286]] 1.0 4cfx Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFXC P24941 1 298 298.0 G6T:61299 Type1 Active DFGin 6.754 15.157 BLAminus -142.34, 170.11 55.48, 71.6 -85.7, 23.38 285.39, 68.53 -51.58, -29.63 in-in in 8.846 Saltbr-in 2.538 HRD-in -79.55, -56.78 72.59, 13.73 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.79, 170.79 APE9-dihe-na 64.39, -170.45 APE8-dihe-in -117.6, 151.27 APE8-rot-in 271.11 APE67-dihe-in -61.81, -23.06 -60.79, -44.0 APE12-dist-in 12.996 APE11-dist-in 10.555 APE10-dist-in 7.357 APE9-dist-in 3.111 None TPO160 TPO160 XRAY 3.5 0.207 0.269 C 303 298 0 0 0 0 [[4, 286]] 1.0 4cfx Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5CYIA P24941 1 298 298.0 55S:60301 Type1 Active DFGin 6.767 14.97 BLAminus -137.64, 176.63 47.15, 80.48 -91.39, 21.66 281.55, 70.58 -67.03, -18.55 in-in in 8.62 Saltbr-in 2.688 HRD-in -78.06, -52.75 68.08, 20.4 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.3, 140.21 APE9-dihe-na 78.36, 138.66 APE8-dihe-in -62.96, 141.91 APE8-rot-in 296.28 APE67-dihe-in -57.57, -24.32 -47.6, -52.43 APE12-dist-in 13.034 APE11-dist-in 10.317 APE10-dist-in 7.494 APE9-dist-in 3.236 None TPO160 TPO160 XRAY 2.0 0.228 0.255 A 303 298 0 0 0 0 [[4, 286]] 1.0 5cyi Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5CYIC P24941 1 296 298.0 55S:60301 Type1 Active DFGin 6.739 14.921 BLAminus -137.77, 174.67 47.68, 81.07 -90.89, 22.34 281.65, 70.16 -66.05, -19.77 in-in in 8.583 Saltbr-in 2.693 HRD-in -76.15, -53.07 68.94, 20.52 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.13, 139.64 APE9-dihe-na 76.95, 137.97 APE8-dihe-in -61.9, 140.82 APE8-rot-in 297.24 APE67-dihe-in -53.17, -25.9 -44.59, -55.44 APE12-dist-in 12.993 APE11-dist-in 10.338 APE10-dist-in 7.436 APE9-dist-in 3.216 None TPO160 TPO160 XRAY 2.0 0.228 0.255 C 303 296 0 0 0 0 [[4, 286]] 1.0 5cyi Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7MKXC P24941 1 296 298.0 ZGY:60301 Type1 Active DFGin 6.277 15.114 BLAminus -140.36, 171.89 55.66, 70.68 -84.32, 23.75 280.3, 66.0 -61.29, -36.7 in-in in 8.541 Saltbr-in 3.198 HRD-in -78.5, -56.26 72.21, 7.67 in-in-in SNCiii in-in ActLoopNT-in 2.774 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.45, 89.97 APE9-dihe-na -178.93, 147.76 APE8-dihe-in -57.48, 133.34 APE8-rot-in 301.11 APE67-dihe-in -60.92, -21.4 -53.06, -47.27 APE12-dist-in 12.957 APE11-dist-in 11.013 APE10-dist-in 6.455 APE9-dist-in 3.741 None TPO160 TPO160 XRAY 3.08 0.248 0.289 C 303 296 0 0 0 0 [[4, 286]] 1.0 7mkx Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFUA P24941 1 298 298.0 2WC:61299 Type1 Active DFGin 6.634 15.251 BLAminus -143.94, -176.45 46.96, 77.88 -92.02, 16.12 280.08, 76.99 -62.89, -22.81 in-in in 8.713 Saltbr-in 2.975 HRD-in -80.47, -54.45 73.66, 15.81 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.95, 168.09 APE9-dihe-na 80.99, 130.01 APE8-dihe-in -53.93, 138.04 APE8-rot-in 303.21 APE67-dihe-in -61.6, -22.53 -50.67, -47.86 APE12-dist-in 13.05 APE11-dist-in 9.288 APE10-dist-in 7.192 APE9-dist-in 3.199 None TPO160 TPO160 XRAY 2.2 0.184 0.221 A 303 296 2 0 0 0 [[4, 286]] 1.0 4cfu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFUC P24941 1 296 298.0 2WC:61297 Type1 Active DFGin 6.577 15.28 BLAminus -141.53, -176.08 45.07, 77.67 -88.55, 18.31 280.58, 72.89 -62.8, -25.25 in-in in 8.673 Saltbr-in 2.72 HRD-in -78.69, -56.62 72.36, 16.74 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.7, 153.81 APE9-dihe-na 73.42, 126.58 APE8-dihe-in -58.01, 141.67 APE8-rot-in 299.68 APE67-dihe-in -60.97, -24.17 -47.05, -49.4 APE12-dist-in 12.745 APE11-dist-in 10.039 APE10-dist-in 6.807 APE9-dist-in 3.208 None TPO160 TPO160 XRAY 2.2 0.184 0.221 C 303 270 26 0 0 0 [[4, 286]] 1.0 4cfu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFVA P24941 1 298 298.0 75X:61299 Type1 Active DFGin 6.645 15.346 BLAminus -137.55, 177.58 52.88, 79.8 -90.24, 13.9 279.4, 75.16 -62.7, -24.78 in-in in 8.815 Saltbr-in 2.538 HRD-in -78.24, -53.69 69.33, 13.55 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.05, 169.07 APE9-dihe-na 75.09, 131.62 APE8-dihe-in -56.21, 139.88 APE8-rot-in 298.93 APE67-dihe-in -57.83, -24.18 -48.22, -53.05 APE12-dist-in 13.152 APE11-dist-in 9.349 APE10-dist-in 7.225 APE9-dist-in 3.189 None TPO160 TPO160 XRAY 2.0 0.18 0.205 A 303 298 0 0 0 0 [[4, 286]] 1.0 4cfv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4CFVC P24941 1 296 298.0 75X:61297 Type1 Active DFGin 6.614 15.334 BLAminus -134.83, -178.5 49.4, 77.95 -89.89, 17.93 278.23, 73.7 -62.88, -26.68 in-in in 8.728 Saltbr-in 3.002 HRD-in -76.67, -55.73 68.34, 12.47 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.17, 150.42 APE9-dihe-na 70.74, 131.03 APE8-dihe-in -55.87, 141.77 APE8-rot-in 303.94 APE67-dihe-in -61.42, -22.75 -47.9, -49.95 APE12-dist-in 12.739 APE11-dist-in 10.096 APE10-dist-in 6.989 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.0 0.18 0.205 C 303 264 32 0 0 0 [[4, 286]] 1.0 4cfv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1VYWC P24941 1 298 298.0 292:62300 Type1 Active DFGin 6.523 15.767 BLAminus -146.25, 178.96 56.14, 83.81 -105.77, 25.65 281.9, 67.54 -64.15, -29.51 in-in in 8.953 Saltbr-in 3.212 HRD-in -73.63, -51.91 70.52, -1.97 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.65, -86.84 APE9-dihe-na -54.67, 131.52 APE8-dihe-in -46.41, 133.51 APE8-rot-in 308.89 APE67-dihe-in -56.19, -27.67 -42.04, -52.59 APE12-dist-in 13.579 APE11-dist-in 12.392 APE10-dist-in 7.698 APE9-dist-in 3.701 None None None XRAY 2.3 0.229 0.258 C 309 298 0 0 0 0 [[4, 286]] 1.0 1vyw Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2BKZA P24941 1 298 298.0 SBC:61299 Type1 Active DFGin 6.28 15.23 BLAminus -142.78, 175.8 58.31, 77.96 -96.55, 27.58 284.6, 62.36 -62.3, -30.15 in-in in 8.582 Saltbr-in 2.806 HRD-in -73.7, -53.54 71.63, -3.26 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.33, -29.51 APE9-dihe-na -59.32, 128.75 APE8-dihe-in -48.05, 131.7 APE8-rot-in 304.88 APE67-dihe-in -54.69, -27.7 -44.06, -56.71 APE12-dist-in 13.532 APE11-dist-in 12.023 APE10-dist-in 6.738 APE9-dist-in 3.734 None None None XRAY 2.6 0.23 0.259 A 309 298 0 0 0 0 [[4, 286]] 1.0 2bkz Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2BKZC P24941 1 297 298.0 SBC:61298 Type1 Active DFGin 6.315 15.267 BLAminus -143.86, 175.39 58.38, 79.09 -98.11, 27.24 283.82, 63.13 -62.03, -28.81 in-in in 8.57 Saltbr-in 2.766 HRD-in -73.89, -52.71 71.33, -3.06 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.29, -29.31 APE9-dihe-na -58.91, 127.76 APE8-dihe-in -47.57, 131.64 APE8-rot-in 304.51 APE67-dihe-in -54.25, -28.48 -45.04, -55.47 APE12-dist-in 13.525 APE11-dist-in 12.026 APE10-dist-in 6.736 APE9-dist-in 3.729 None None None XRAY 2.6 0.23 0.259 C 309 297 0 0 0 0 [[4, 286]] 1.0 2bkz Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2BPMC P24941 1 298 298.0 529:61299 Type1 Active DFGin 6.476 15.691 BLAminus -139.11, -176.99 50.31, 82.01 -98.98, 24.72 279.58, 68.95 -62.44, -20.88 in-in in 8.975 Saltbr-in 3.405 HRD-in -80.64, -57.02 72.88, 2.66 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.51, -77.27 APE9-dihe-na -63.86, 135.95 APE8-dihe-in -52.79, 132.77 APE8-rot-in 309.35 APE67-dihe-in -57.16, -24.3 -34.82, -55.34 APE12-dist-in 13.242 APE11-dist-in 11.949 APE10-dist-in 7.171 APE9-dist-in 3.521 None None None XRAY 2.4 0.229 0.271 C 309 298 0 0 0 0 [[4, 286]] 1.0 2bpm Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C4GC P24941 1 298 298.0 514:60306 Type1 Active DFGin 6.367 15.719 BLAminus -139.83, -179.8 56.9, 82.39 -100.75, 22.8 279.84, 72.16 -55.14, -30.61 in-in in 9.107 Saltbr-in 3.525 HRD-in -76.45, -47.57 65.3, 7.78 in-in-in SNCiii in-in ActLoopNT-in 2.765 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.95, -47.05 APE9-dihe-na -79.06, 130.37 APE8-dihe-in -53.02, 141.81 APE8-rot-in 298.24 APE67-dihe-in -53.93, -25.26 -49.41, -57.46 APE12-dist-in 13.735 APE11-dist-in 11.863 APE10-dist-in 6.729 APE9-dist-in 3.743 None None None XRAY 2.7 0.233 0.25 C 309 298 0 0 0 0 [[4, 286]] 1.0 2c4g Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WIHC P24941 1 298 298.0 P48:61299 Type1 Active DFGin 6.515 15.502 BLAminus -139.53, 171.28 64.6, 87.79 -105.04, 25.11 279.58, 71.52 -58.59, -37.4 in-in in 8.856 Saltbr-in 2.9 HRD-in -79.72, -52.5 76.18, -5.97 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.83, -70.3 APE9-dihe-na -57.72, 136.41 APE8-dihe-in -51.89, 139.14 APE8-rot-in 308.59 APE67-dihe-in -63.31, -27.96 -57.76, -40.98 APE12-dist-in 13.362 APE11-dist-in 12.02 APE10-dist-in 7.022 APE9-dist-in 3.642 None None None XRAY 2.5 0.215 0.25 C 309 298 0 0 0 0 [[4, 286]] 1.0 2wih Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WPAC P24941 1 298 298.0 889:61300 Type1 Active DFGin 6.557 15.668 BLAminus -144.77, 174.3 58.47, 90.93 -109.08, 19.58 277.99, 68.6 -59.79, -26.46 in-in in 9.033 Saltbr-in 2.675 HRD-in -78.48, -54.37 78.2, -2.73 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.71, -53.13 APE9-dihe-na -78.14, 130.12 APE8-dihe-in -48.02, 138.87 APE8-rot-in 297.69 APE67-dihe-in -59.43, -34.95 -58.75, -45.0 APE12-dist-in 13.596 APE11-dist-in 11.656 APE10-dist-in 6.669 APE9-dist-in 3.482 None None None XRAY 2.51 0.223 0.261 C 309 298 0 0 0 0 [[4, 286]] 1.0 2wpa Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6GUEA P24941 1 298 298.0 FB8:60301 Type1 Active DFGin 6.754 15.496 BLAminus -136.13, 174.07 55.03, 81.74 -90.85, 16.49 281.66, 71.64 -57.24, -30.62 in-in in 8.788 Saltbr-in 2.403 HRD-in -77.82, -55.96 73.4, 10.98 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.32, 165.89 APE9-dihe-na 84.86, 131.41 APE8-dihe-in -49.42, 131.75 APE8-rot-in 295.4 APE67-dihe-in -60.88, -20.37 -49.88, -45.18 APE12-dist-in 13.336 APE11-dist-in 12.57 APE10-dist-in 7.556 APE9-dist-in 3.205 None TPO160 TPO160 XRAY 1.99 0.198 0.234 A 302 293 5 0 0 0 [[4, 286]] 1.0 6gue Homo sapiens CMGC_CDK2_HUMAN CMGC 6.9e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2IW8A P24941 1 297 298.0 4SP:61298 Type1 Active DFGin 6.907 14.876 BLAminus -128.94, 178.15 45.79, 77.82 -89.54, 20.73 278.33, 75.94 -62.77, -23.59 in-in in 8.52 Saltbr-in 2.678 HRD-in -82.44, -53.34 71.08, 17.45 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.18, 148.54 APE9-dihe-na 67.67, 128.23 APE8-dihe-in -55.32, 132.5 APE8-rot-in 304.46 APE67-dihe-in -56.59, -27.86 -44.81, -49.42 APE12-dist-in 12.947 APE11-dist-in 10.439 APE10-dist-in 7.316 APE9-dist-in 3.253 F82H,L83V,H84D TPO160 TPO160 XRAY 2.3 0.214 0.255 A 302 297 0 0 0 0 [[4, 286]] 1.0 2iw8 Homo sapiens CMGC_CDK2_HUMAN CMGC 1.1e-89 307.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2IW8C P24941 1 296 298.0 4SP:61297 Type1 Active DFGin 6.776 14.993 BLAminus -119.11, -171.67 36.55, 74.77 -80.97, 23.02 280.6, 75.2 -62.4, -19.17 in-in in 8.672 Saltbr-in 2.482 HRD-in -81.37, -52.61 71.76, 20.77 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.18, 153.02 APE9-dihe-na 61.13, 127.0 APE8-dihe-in -47.11, 147.78 APE8-rot-in 315.45 APE67-dihe-in -43.58, -23.45 -49.47, -61.15 APE12-dist-in 12.906 APE11-dist-in 9.942 APE10-dist-in 7.204 APE9-dist-in 3.417 F82H,L83V,H84D TPO160 TPO160 XRAY 2.3 0.214 0.255 C 302 265 31 0 0 0 [[4, 286]] 1.0 2iw8 Homo sapiens CMGC_CDK2_HUMAN CMGC 1.1e-89 307.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESKC P24941 1 296 298.0 W3D:60501,W3D:60502 Type1,Allosteric Active DFGin 6.638 15.284 BLAminus -137.51, -173.46 49.66, 73.42 -88.73, 25.05 278.15, 71.06 -63.4, -24.24 in-in in 8.507 Saltbr-in 2.776 HRD-in -81.97, -57.15 70.97, 10.51 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.08, 143.45 APE9-dihe-na 79.68, 124.98 APE8-dihe-in -55.57, 144.7 APE8-rot-in 305.12 APE67-dihe-in -55.94, -29.23 -48.29, -54.73 APE12-dist-in 12.79 APE11-dist-in 10.221 APE10-dist-in 6.996 APE9-dist-in 3.215 None TPO160 TPO160 XRAY 2.398 0.211 0.217 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esk Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESLC P24941 1 296 298.0 V3U:60301,V3U:60302 Type1,Allosteric Active DFGin 6.673 15.405 BLAminus -140.55, -177.95 50.02, 80.84 -92.78, 20.52 278.3, 72.54 -61.36, -26.37 in-in in 8.635 Saltbr-in 2.812 HRD-in -80.59, -57.08 73.08, 12.06 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.86, 147.72 APE9-dihe-na 75.57, 125.72 APE8-dihe-in -53.85, 140.25 APE8-rot-in 308.57 APE67-dihe-in -54.82, -27.93 -44.39, -53.4 APE12-dist-in 12.718 APE11-dist-in 10.064 APE10-dist-in 6.858 APE9-dist-in 3.263 None TPO160 TPO160 XRAY 2.392 0.217 0.22 C 302 268 28 0 0 0 [[4, 286]] 1.0 9esl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESNC P24941 1 296 298.0 UUS:60501,UUS:60502 Type1,Allosteric Active DFGin 6.783 15.35 BLAminus -134.32, -173.37 48.7, 77.83 -95.39, 23.82 280.48, 71.42 -70.86, -18.35 in-in in 8.469 Saltbr-in 2.858 HRD-in -86.45, -56.57 72.38, 12.62 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.86, 146.56 APE9-dihe-na 76.71, 123.38 APE8-dihe-in -49.22, 142.2 APE8-rot-in 311.1 APE67-dihe-in -53.84, -27.08 -45.75, -55.53 APE12-dist-in 12.859 APE11-dist-in 10.419 APE10-dist-in 6.951 APE9-dist-in 3.287 None TPO160 TPO160 XRAY 2.393 0.209 0.213 C 302 296 0 0 0 0 [[4, 286]] 1.0 9esn Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESRC P24941 1 296 298.0 UU1:60501,UU1:60502 Type1,Allosteric Active DFGin 6.652 15.072 BLAminus -145.73, -177.82 46.05, 80.55 -92.88, 23.57 287.5, 67.77 -53.91, -33.17 in-in in 8.317 Saltbr-in 2.701 HRD-in -84.72, -55.44 71.68, 6.95 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.21, 146.03 APE9-dihe-na 73.67, 122.79 APE8-dihe-in -45.48, 138.32 APE8-rot-in 312.39 APE67-dihe-in -52.0, -25.98 -45.15, -57.7 APE12-dist-in 12.99 APE11-dist-in 10.131 APE10-dist-in 7.114 APE9-dist-in 3.175 None TPO160 TPO160 XRAY 2.388 0.221 0.227 C 302 266 30 0 0 0 [[4, 286]] 1.0 9esr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESSC P24941 1 296 298.0 UUG:60501,UUG:60502 Type1,Allosteric Active DFGin 6.631 14.933 BLAminus -142.84, 175.97 51.2, 79.73 -89.56, 21.72 284.95, 67.51 -58.42, -34.37 in-in in 8.295 Saltbr-in 2.868 HRD-in -75.14, -63.05 75.45, 9.68 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.9, 146.77 APE9-dihe-na 74.13, 121.78 APE8-dihe-in -44.27, 147.71 APE8-rot-in 310.11 APE67-dihe-in -53.57, -23.24 -51.44, -55.49 APE12-dist-in 12.636 APE11-dist-in 9.974 APE10-dist-in 6.855 APE9-dist-in 3.245 None TPO160 TPO160 XRAY 2.44 0.212 0.219 C 302 265 31 0 0 0 [[4, 286]] 1.0 9ess Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESVC P24941 1 295 298.0 3Z7:60501,3Z7:60502 Type1,Allosteric Active DFGin 6.768 15.236 BLAminus -139.75, 176.56 54.81, 81.21 -90.94, 16.67 278.85, 71.78 -56.97, -37.98 in-in in 8.453 Saltbr-in 2.882 HRD-in -80.1, -61.08 77.4, 12.62 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.79, 159.88 APE9-dihe-na 80.45, 128.43 APE8-dihe-in -53.65, 150.6 APE8-rot-in 315.25 APE67-dihe-in -53.52, -24.6 -48.05, -59.38 APE12-dist-in 12.614 APE11-dist-in 11.366 APE10-dist-in 6.641 APE9-dist-in 3.219 None TPO160 TPO160 XRAY 2.397 0.227 0.229 C 302 264 31 0 0 0 [[4, 286]] 1.0 9esv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESXA P24941 1 290 298.0 A1H6Y:60601,A1H6Y:60602 Type1,Allosteric Active DFGin 6.653 15.338 BLAminus -144.59, 175.62 57.61, 83.73 -105.01, 35.81 281.7, 71.92 -82.28, -22.63 in-in in 8.596 Saltbr-in 2.992 HRD-in -81.07, -59.53 79.35, 13.94 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.52, 145.33 APE9-dihe-na 77.45, 118.76 APE8-dihe-in -49.06, 129.75 APE8-rot-in 301.07 APE67-dihe-in -59.92, -20.73 -43.74, -50.25 APE12-dist-in 12.802 APE11-dist-in 9.82 APE10-dist-in 7.12 APE9-dist-in 3.283 None TPO160 TPO160 XRAY 2.37 0.222 0.229 A 302 290 0 0 0 0 [[4, 286]] 1.0 9esx Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET4A P24941 1 292 298.0 A1H6X:60601,A1H6X:60603 Type1,Allosteric Active DFGin 6.633 15.549 BLAminus -134.84, 172.65 61.14, 83.32 -99.32, 22.95 280.23, 75.12 -63.71, -31.1 in-in in 8.693 Saltbr-in 3.125 HRD-in -81.89, -57.78 79.18, 16.7 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.49, 161.44 APE9-dihe-na 79.45, 129.92 APE8-dihe-in -54.31, 127.59 APE8-rot-in 279.58 APE67-dihe-in -56.0, -21.82 -38.83, -54.37 APE12-dist-in 13.033 APE11-dist-in 12.229 APE10-dist-in 7.259 APE9-dist-in 3.405 None TPO160 TPO160 XRAY 2.641 0.22 0.222 A 302 289 3 0 0 0 [[4, 286]] 1.0 9et4 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET4C P24941 1 294 298.0 A1H6X:60501,A1H6X:60502 Type1,Allosteric Active DFGin 6.649 15.437 BLAminus -135.93, -174.31 48.97, 78.73 -88.03, 26.85 282.26, 61.74 -61.22, -38.83 in-in in 8.613 Saltbr-in 2.78 HRD-in -94.76, -49.17 61.89, 17.84 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.87, 147.92 APE9-dihe-na 79.68, 125.87 APE8-dihe-in -54.62, 145.03 APE8-rot-in 295.75 APE67-dihe-in -55.12, -26.19 -51.19, -50.76 APE12-dist-in 12.808 APE11-dist-in 10.219 APE10-dist-in 6.955 APE9-dist-in 3.301 None TPO160 TPO160 XRAY 2.641 0.22 0.222 C 302 294 0 0 0 0 [[4, 286]] 1.0 9et4 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET5A P24941 1 294 298.0 T5G:60501,T5G:60503 Type1,Allosteric Active DFGin 6.678 15.291 BLAminus -137.17, 178.34 60.51, 85.6 -108.17, 31.01 281.27, 78.69 -80.57, -23.43 in-in in 8.726 Saltbr-in 2.905 HRD-in -80.11, -56.4 77.63, 19.45 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.95, 140.76 APE9-dihe-na 77.59, 129.77 APE8-dihe-in -58.29, 133.79 APE8-rot-in 288.36 APE67-dihe-in -61.58, -15.9 -39.95, -50.82 APE12-dist-in 12.774 APE11-dist-in 9.662 APE10-dist-in 7.134 APE9-dist-in 3.396 None TPO160 TPO160 XRAY 2.53 0.201 0.221 A 302 294 0 0 0 0 [[4, 286]] 1.0 9et5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET5C P24941 1 296 298.0 T5G:60501,T5G:60502 Type1,Allosteric Active DFGin 6.662 15.494 BLAminus -134.15, -179.13 56.52, 75.78 -94.35, 30.58 280.05, 68.52 -72.1, -25.78 in-in in 8.742 Saltbr-in 2.669 HRD-in -82.99, -55.97 71.28, 11.54 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.03, 145.44 APE9-dihe-na 80.72, 131.2 APE8-dihe-in -58.76, 142.02 APE8-rot-in 303.79 APE67-dihe-in -55.68, -24.95 -43.97, -53.66 APE12-dist-in 12.765 APE11-dist-in 10.549 APE10-dist-in 6.832 APE9-dist-in 3.271 None TPO160 TPO160 XRAY 2.53 0.201 0.221 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET7A P24941 1 289 298.0 HGQ:60301,HGQ:60302 Type1,Allosteric Active DFGin 6.684 15.297 BLAminus -134.16, 175.42 60.98, 76.23 -92.01, 22.87 281.63, 72.75 -65.33, -31.28 in-in in 8.681 Saltbr-in 2.981 HRD-in -77.49, -57.6 73.35, 16.1 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.54, 163.96 APE9-dihe-na 75.76, 128.99 APE8-dihe-in -52.61, 137.53 APE8-rot-in 306.37 APE67-dihe-in -58.89, -21.47 -51.05, -48.57 APE12-dist-in 13.218 APE11-dist-in 11.88 APE10-dist-in 7.023 APE9-dist-in 3.295 None TPO160 TPO160 XRAY 2.312 0.241 0.271 A 302 289 0 0 0 0 [[4, 286]] 1.0 9et7 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET9C P24941 1 296 298.0 HEW:60701,HEW:60702 Type1,Allosteric Active DFGin 6.777 15.342 BLAminus -145.5, -178.18 52.74, 79.01 -102.36, 32.74 279.23, 71.65 -77.89, -27.55 in-in in 8.53 Saltbr-in 3.195 HRD-in -81.68, -55.92 73.5, 13.51 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.61, 143.17 APE9-dihe-na 75.3, 125.76 APE8-dihe-in -51.4, 141.63 APE8-rot-in 308.72 APE67-dihe-in -57.1, -22.45 -43.98, -53.09 APE12-dist-in 12.701 APE11-dist-in 9.99 APE10-dist-in 7.15 APE9-dist-in 3.279 None TPO160 TPO160 XRAY 2.494 0.225 0.246 C 302 286 10 0 0 0 [[4, 286]] 1.0 9et9 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESJC P24941 1 296 298.0 HHT:60501,HHT:60502,HHT:60503 Type1,Allosteric,Allosteric Active DFGin 6.615 15.221 BLAminus -137.79, -171.11 40.67, 80.8 -88.42, 26.95 282.0, 68.25 -67.86, -17.18 in-in in 8.634 Saltbr-in 2.934 HRD-in -82.8, -62.24 79.8, 7.77 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.91, 149.4 APE9-dihe-na 72.98, 130.17 APE8-dihe-in -58.17, 146.1 APE8-rot-in 299.44 APE67-dihe-in -57.51, -23.31 -50.67, -52.77 APE12-dist-in 12.625 APE11-dist-in 9.906 APE10-dist-in 6.704 APE9-dist-in 3.201 None TPO160 TPO160 XRAY 2.37 0.218 0.223 C 302 269 27 0 0 0 [[4, 286]] 1.0 9esj Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESKA P24941 1 298 298.0 W3D:60601,W3D:60602,W3D:60603 Type1,Allosteric,Allosteric Active DFGin 6.761 15.251 BLAminus -134.47, 176.96 63.67, 79.26 -100.81, 21.22 280.31, 65.37 -78.45, -3.37 in-in in 8.832 Saltbr-in 3.149 HRD-in -81.68, -58.97 75.36, 18.24 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.89, 148.76 APE9-dihe-na 77.48, 128.01 APE8-dihe-in -56.0, 131.29 APE8-rot-in 290.87 APE67-dihe-in -61.94, -19.93 -42.42, -49.49 APE12-dist-in 12.912 APE11-dist-in 10.136 APE10-dist-in 7.275 APE9-dist-in 3.215 None TPO160 TPO160 XRAY 2.398 0.211 0.217 A 302 298 0 0 0 0 [[4, 286]] 1.0 9esk Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESLA P24941 1 297 298.0 V3U:60301,V3U:60302,V3U:60303 Type1,Allosteric,Allosteric Active DFGin 6.621 15.27 BLAminus -138.4, 178.74 56.73, 85.65 -102.78, 26.09 280.14, 70.92 -77.54, -19.71 in-in in 8.794 Saltbr-in 3.258 HRD-in -84.5, -55.59 73.62, 15.91 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -52.9, 163.47 APE9-dihe-na 75.95, 128.72 APE8-dihe-in -54.92, 137.6 APE8-rot-in 298.46 APE67-dihe-in -62.23, -17.31 -55.18, -44.63 APE12-dist-in 12.988 APE11-dist-in 11.939 APE10-dist-in 7.114 APE9-dist-in 3.154 None TPO160 TPO160 XRAY 2.392 0.217 0.22 A 302 297 0 0 0 0 [[4, 286]] 1.0 9esl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET3C P24941 1 296 298.0 1P8:60301,1P8:60302,1P8:60303 Type1,Allosteric,Allosteric Active DFGin 6.634 15.417 BLAminus -136.42, -175.2 49.61, 75.4 -86.05, 23.32 281.27, 67.67 -65.65, -24.86 in-in in 8.523 Saltbr-in 2.969 HRD-in -85.78, -54.86 74.66, 10.97 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.99, 147.59 APE9-dihe-na 75.0, 128.74 APE8-dihe-in -56.23, 140.22 APE8-rot-in 313.04 APE67-dihe-in -53.49, -26.15 -43.22, -56.6 APE12-dist-in 12.74 APE11-dist-in 10.131 APE10-dist-in 6.699 APE9-dist-in 3.146 None TPO160 TPO160 XRAY 2.34 0.185 0.221 C 302 265 31 0 0 0 [[4, 286]] 1.0 9et3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET6C P24941 1 296 298.0 HHQ:60301,HHQ:60302,HHQ:60303 Type1,Allosteric,Allosteric Active DFGin 6.873 15.729 BLAminus -138.12, -175.76 50.55, 79.21 -99.63, 40.16 275.32, 72.76 -79.96, -35.84 in-in in 8.822 Saltbr-in 3.04 HRD-in -79.3, -57.91 70.96, 13.7 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.02, -81.33 APE9-dihe-na -75.9, 158.42 APE8-dihe-in -63.8, 136.86 APE8-rot-in 315.58 APE67-dihe-in -58.45, -31.02 -40.63, -49.71 APE12-dist-in 12.649 APE11-dist-in 9.98 APE10-dist-in 6.835 APE9-dist-in 3.427 None TPO160 TPO160 XRAY 2.553 0.224 0.239 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et6 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ET8C P24941 1 296 298.0 IIS:60301,IIS:60302,IIS:60303 Type1,Allosteric,Allosteric Active DFGin 6.522 15.277 BLAminus -138.22, -178.04 53.64, 77.44 -93.34, 27.5 282.32, 70.76 -68.0, -30.89 in-in in 8.567 Saltbr-in 2.796 HRD-in -80.95, -56.88 70.51, 15.08 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.44, 149.31 APE9-dihe-na 74.52, 129.52 APE8-dihe-in -54.76, 135.97 APE8-rot-in 303.9 APE67-dihe-in -62.13, -18.99 -42.4, -52.2 APE12-dist-in 12.842 APE11-dist-in 10.128 APE10-dist-in 6.95 APE9-dist-in 3.297 None TPO160 TPO160 XRAY 2.31 0.226 0.242 C 302 296 0 0 0 0 [[4, 286]] 1.0 9et8 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ETBC P24941 1 296 298.0 PYZ:60501,PYZ:60502,PYZ:60504 Type1,Allosteric,Allosteric Active DFGin 6.746 15.019 BLAminus -143.48, -178.64 51.51, 80.46 -98.47, 34.67 277.11, 78.33 -78.48, -28.12 in-in in 8.406 Saltbr-in 2.918 HRD-in -77.32, -49.73 69.21, 13.85 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.33, 153.34 APE9-dihe-na 65.12, 133.84 APE8-dihe-in -56.36, 138.43 APE8-rot-in 308.36 APE67-dihe-in -58.62, -30.85 -38.23, -52.66 APE12-dist-in 12.539 APE11-dist-in 9.601 APE10-dist-in 6.617 APE9-dist-in 3.468 None TPO160 TPO160 XRAY 2.76 0.213 0.228 C 302 284 12 0 0 0 [[4, 286]] 1.0 9etb Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ETPC P24941 1 296 298.0 BYZ:60501,BYZ:60502,BYZ:60503 Type1,Allosteric,Allosteric Active DFGin 6.563 15.026 BLAminus -139.85, -178.12 50.6, 80.08 -91.54, 27.1 284.21, 67.12 -60.57, -29.59 in-in in 8.597 Saltbr-in 2.956 HRD-in -84.41, -56.87 79.21, 8.08 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.1, 146.93 APE9-dihe-na 73.24, 128.07 APE8-dihe-in -58.4, 133.61 APE8-rot-in 297.06 APE67-dihe-in -57.21, -23.28 -33.45, -54.48 APE12-dist-in 12.759 APE11-dist-in 9.665 APE10-dist-in 6.816 APE9-dist-in 3.36 None TPO160 TPO160 XRAY 2.48 0.202 0.231 C 302 279 17 0 0 0 [[4, 286]] 1.0 9etp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESJA P24941 1 296 298.0 HHT:60601,HHT:60602,HHT:60603,HHT:60604 Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.527 15.324 BLAminus -137.61, -177.13 52.74, 75.68 -90.81, 24.42 279.7, 71.63 -65.27, -23.85 in-in in 8.726 Saltbr-in 3.1 HRD-in -83.71, -57.04 74.68, 18.49 in-in-in SNCiii in-in ActLoopNT-in 3.032 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.23, 145.1 APE9-dihe-na 79.14, 127.92 APE8-dihe-in -56.7, 137.49 APE8-rot-in 297.98 APE67-dihe-in -59.94, -16.79 -51.82, -49.73 APE12-dist-in 12.876 APE11-dist-in 10.06 APE10-dist-in 7.034 APE9-dist-in 3.266 None TPO160 TPO160 XRAY 2.37 0.218 0.223 A 302 296 0 0 0 0 [[4, 286]] 1.0 9esj Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESQA P24941 1 296 298.0 IT4:60601,IT4:60602,IT4:60603,IT4:60604 Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.573 15.319 BLAminus -138.63, 177.23 53.97, 82.44 -94.2, 22.34 276.67, 75.86 -65.53, -24.16 in-in in 8.618 Saltbr-in 2.754 HRD-in -82.0, -53.66 73.59, 16.79 in-in-in SNCiii in-in ActLoopNT-in 3.116 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.91, 166.55 APE9-dihe-na 80.06, 129.5 APE8-dihe-in -59.98, 139.75 APE8-rot-in 298.87 APE67-dihe-in -65.21, -16.21 -49.51, -47.69 APE12-dist-in 13.141 APE11-dist-in 11.71 APE10-dist-in 7.098 APE9-dist-in 3.16 None TPO160 TPO160 XRAY 2.38 0.206 0.21 A 302 296 0 0 0 0 [[4, 286]] 1.0 9esq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ESVA P24941 1 298 298.0 3Z7:60601,3Z7:60602,3Z7:60603,3Z7:60604 Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.66 15.169 BLAminus -141.68, -175.45 45.66, 89.4 -98.16, 27.65 279.63, 71.93 -70.26, -29.25 in-in in 8.594 Saltbr-in 3.495 HRD-in -83.94, -54.63 72.69, 21.44 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.28, 170.55 APE9-dihe-na 72.91, 133.83 APE8-dihe-in -55.57, 128.45 APE8-rot-in 293.2 APE67-dihe-in -57.93, -20.57 -41.03, -48.86 APE12-dist-in 12.894 APE11-dist-in 12.234 APE10-dist-in 7.324 APE9-dist-in 3.227 None TPO160 TPO160 XRAY 2.397 0.227 0.229 A 302 298 0 0 0 0 [[4, 286]] 1.0 9esv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9ETPA P24941 1 297 298.0 BYZ:60601,BYZ:60603,BYZ:60604,BYZ:60605,BYZ:60606,BYZ:60607 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Active DFGin 6.84 15.494 BLAminus -127.49, -178.48 53.77, 85.13 -106.7, 35.09 276.24, 76.74 -80.48, -25.81 in-in in 8.546 Saltbr-in 3.046 HRD-in -77.4, -56.67 72.11, 14.41 in-in-in SNCiii in-in ActLoopNT-in 2.95 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.24, 146.07 APE9-dihe-na 79.12, 126.78 APE8-dihe-in -56.13, 139.51 APE8-rot-in 303.8 APE67-dihe-in -55.08, -20.41 -52.32, -47.85 APE12-dist-in 12.587 APE11-dist-in 9.765 APE10-dist-in 6.877 APE9-dist-in 3.285 None TPO160 TPO160 XRAY 2.48 0.202 0.231 A 302 294 3 0 0 0 [[4, 286]] 1.0 9etp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3BHUC P24941 1 296 298.0 MHR:60299 Type1.5_Back Active DFGin 6.711 14.747 BLAminus -135.55, 171.6 58.78, 89.32 -103.71, 20.04 281.06, 67.57 -60.23, -27.81 in-in in 8.385 Saltbr-in 2.558 HRD-in -83.56, -56.59 72.77, 13.78 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -30.58, 137.53 APE9-dihe-na 72.29, 126.42 APE8-dihe-in -48.13, 131.39 APE8-rot-in 307.87 APE67-dihe-in -59.11, -18.02 -39.31, -52.67 APE12-dist-in 12.706 APE11-dist-in 9.599 APE10-dist-in 7.189 APE9-dist-in 3.322 None TPO160 TPO160 XRAY 2.3 0.197 0.24 C 300 270 26 0 0 0 [[4, 286]] 1.0 3bhu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8BZOA P24941 14 297 298.0 No_ligand No_ligand Inactive DFGin 6.628 16.75 ABAminus -113.33, -60.04 -92.34, 117.63 -115.4, 17.23 269.19, 90.3 -63.34, -41.25 out-none out 10.219 Saltbr-none 999.0 HRD-out -86.82, 152.4 -117.77, -56.48 none-in-out SNCnio in-out ActLoopNT-in 3.194 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -98.87, -25.79 APE9-dihe-na -64.18, 153.29 APE8-dihe-in -63.18, 147.0 APE8-rot-out 47.23 APE67-dihe-in -65.24, -14.81 -65.84, -44.21 APE12-dist-in 9.694 APE11-dist-in 12.285 APE10-dist-in 6.835 APE9-dist-in 5.533 None TPO160 TPO160 EM 3.5 999.0 999.0 A 297 284 10 0 0 0 [[4, 286]] 1.0 8bzo Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5NEVA P24941 1 295 298.0 72L:60301 Type1 Inactive DFGin 7.05 15.722 ABAminus -138.48, -8.77 -130.24, 91.18 -84.62, 13.88 280.22, 71.78 -70.55, -13.54 in-out in 8.796 Saltbr-out 3.697 HRD-in -77.87, -47.01 62.16, 19.64 out-in-out SNCoio in-out ActLoopNT-in 3.196 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.01, -38.47 APE9-dihe-na -96.82, 160.63 APE8-dihe-in -60.36, 142.07 APE8-rot-out 80.07 APE67-dihe-in -59.09, -25.56 -48.5, -47.43 APE12-dist-in 13.216 APE11-dist-in 11.905 APE10-dist-in 7.98 APE9-dist-in 3.72 None TPO160 TPO160 XRAY 2.97 0.22 0.261 A 303 295 0 0 0 0 [[4, 286]] 1.0 5nev Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5NEVC P24941 1 296 298.0 72L:60301 Type1 Inactive DFGin 6.939 15.882 ABAminus -143.97, -12.19 -126.52, 90.93 -83.33, 12.48 277.79, 75.94 -69.32, -11.34 in-out in 8.874 Saltbr-out 3.991 HRD-out -97.5, 94.45 -92.19, 48.01 out-in-in SNCoii in-in ActLoopNT-in 3.204 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.27, -51.5 APE9-dihe-na -94.91, 150.97 APE8-dihe-in -53.84, 139.76 APE8-rot-in 308.05 APE67-dihe-in -58.52, -25.48 -46.89, -47.67 APE12-dist-in 13.121 APE11-dist-in 11.579 APE10-dist-in 7.239 APE9-dist-in 3.652 None TPO160 TPO160 XRAY 2.97 0.22 0.261 C 303 296 0 0 0 0 [[4, 286]] 1.0 5nev Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOOA P24941 1 297 298.0 ATP:60302 ATPlike Inactive DFGin 6.651 15.121 BLAminus -137.3, -178.29 51.93, 74.48 -88.78, 23.73 283.58, 71.37 -66.89, -17.34 in-in in 8.754 Saltbr-in 2.774 HRD-in -82.21, -55.51 72.81, 10.91 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.74, 151.81 APE9-dihe-na 71.22, 125.56 APE8-dihe-in -63.52, 145.17 APE8-rot-out 106.26 APE67-dihe-in -59.56, -25.92 -46.12, -48.45 APE12-dist-in 12.954 APE11-dist-in 10.307 APE10-dist-in 7.133 APE9-dist-in 3.247 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 A 299 293 4 0 0 0 [[4, 286]] 1.0 4eoo Homo sapiens CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOOC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.441 15.255 BLAminus -132.94, -176.35 50.17, 74.17 -84.23, 27.4 283.88, 71.77 -62.65, -24.02 in-in in 8.772 Saltbr-in 2.725 HRD-in -84.21, -52.66 66.89, 14.22 in-in-out SNCiio in-out ActLoopNT-in 2.986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.67, 158.22 APE9-dihe-na 65.39, 129.96 APE8-dihe-in -70.44, 149.36 APE8-rot-out 84.06 APE67-dihe-in -53.86, -24.11 -49.71, -53.55 APE12-dist-in 12.807 APE11-dist-in 10.003 APE10-dist-in 6.75 APE9-dist-in 3.286 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 C 299 296 0 0 0 0 [[4, 286]] 1.0 4eoo Homo sapiens CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOMA P24941 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.766 15.173 BLAminus -135.89, -179.95 56.75, 76.33 -93.68, 18.3 281.75, 72.51 -65.02, -17.06 in-in in 8.656 Saltbr-in 2.954 HRD-in -79.7, -58.84 74.79, 7.53 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 71.17, 129.47 APE9-dihe-na 73.49, 129.68 APE8-dihe-in -66.58, 140.55 APE8-rot-out 117.21 APE67-dihe-in -54.12, -27.93 -44.4, -51.19 APE12-dist-in 13.269 APE11-dist-in 9.227 APE10-dist-in 7.153 APE9-dist-in 3.259 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 A 301 295 2 0 0 0 [[4, 286]] 1.0 4eom Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOMC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.612 15.121 BLAminus -134.3, 179.46 56.9, 73.57 -89.28, 27.08 288.28, 71.72 -61.57, -29.46 in-in in 8.464 Saltbr-in 2.764 HRD-in -79.86, -55.51 70.21, 14.99 in-in-out SNCiio in-out ActLoopNT-in 2.988 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.3, 158.32 APE9-dihe-na 61.45, 125.91 APE8-dihe-in -61.76, 140.91 APE8-rot-out 72.97 APE67-dihe-in -49.53, -25.94 -36.27, -61.03 APE12-dist-in 12.846 APE11-dist-in 9.68 APE10-dist-in 6.944 APE9-dist-in 3.36 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 C 301 272 24 0 0 0 [[4, 286]] 1.0 4eom Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1FINA P24941 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.269 15.397 BLAminus -145.66, 175.42 60.17, 70.41 -88.62, 22.31 287.3, 65.31 -62.81, -23.63 in-in in 8.878 Saltbr-in 3.066 HRD-in -75.81, -52.6 66.76, 11.52 in-in-out SNCiio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -159.69, 149.42 APE9-dihe-na -56.35, 161.85 APE8-dihe-in -65.27, 149.59 APE8-rot-out 191.08 APE67-dihe-in -48.48, -30.03 -41.87, -56.23 APE12-dist-in 10.428 APE11-dist-out 5.924 APE10-dist-out 8.991 APE9-dist-in 4.147 None None None XRAY 2.3 0.208 999.0 A 298 298 0 0 0 0 [[4, 286]] 1.0 1fin Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1FINC P24941 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.329 16.114 BLAminus -126.26, 177.09 60.06, 80.37 -100.41, 24.94 280.63, 71.46 -64.88, -37.23 in-in in 9.234 Saltbr-in 3.016 HRD-in -71.64, -45.48 67.73, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.657 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -100.08, 164.84 APE9-dihe-na -64.11, 161.66 APE8-dihe-in -58.82, 141.21 APE8-rot-in 296.75 APE67-dihe-in -52.5, -36.66 -49.82, -46.41 APE12-dist-in 10.426 APE11-dist-out 6.239 APE10-dist-out 9.723 APE9-dist-in 3.907 None None None XRAY 2.3 0.208 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 1fin Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1FQ1B P24941 1 296 298.0 ATP:381 ATPlike Inactive DFGin 6.774 15.622 BLAminus -151.24, -169.54 37.68, 67.63 -81.17, 26.85 274.26, 50.62 -66.75, -18.36 in-out in 9.807 Saltbr-out 3.73 HRD-in -76.57, -60.94 80.93, -25.61 out-in-out SNCoio in-out ActLoopNT-in 2.61 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oioo APE10-dihe-na -104.21, 92.46 APE9-dihe-na -93.56, -175.8 APE8-dihe-out -64.18, -46.74 APE8-rot-in 317.22 APE67-dihe-out -56.53, -27.84 69.72, -12.02 APE12-dist-out 16.113 APE11-dist-in 11.902 APE10-dist-out 15.594 APE9-dist-out 10.131 None TPO160 TPO160 XRAY 3.0 0.235 0.313 B 298 296 0 0 0 0 [[4, 286]] 1.0 1fq1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9I9JK P24941 6 284 298.0 ADP:60301 ATPlike Inactive DFGin 7.502 16.779 BLAminus -158.16, 171.41 58.55, 63.81 -89.46, 61.19 266.29, 72.56 161.2, 999.0 in-out in 9.119 Saltbr-out 5.255 HRD-in -89.48, -59.44 66.59, -3.23 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -47.83 APE8-dihe-out -98.29, 31.77 APE8-rot-out 77.96 APE67-dihe-in -64.85, -20.6 -65.62, -27.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.13 None None None EM 3.1 999.0 999.0 K 301 246 37 0 0 16 [[4, 286]] 1.0 9i9j Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9I9KK P24941 2 292 298.0 ADP:60301 ATPlike Inactive DFGin 7.302 15.906 BLAminus -142.34, -176.15 60.61, 65.17 -90.86, 48.23 288.67, 80.56 -88.9, -30.85 out-out out 10.486 Saltbr-out 5.65 HRD-in -65.4, -52.43 72.61, -10.3 out-in-out SNCoio in-out ActLoopNT-in 2.558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -73.37, 146.13 APE9-dihe-na -115.04, 137.49 APE8-dihe-in -60.96, 144.59 APE8-rot-out 184.92 APE67-dihe-in -75.1, -11.28 -107.26, -12.43 APE12-dist-in 12.011 APE11-dist-in 8.187 APE10-dist-out 12.049 APE9-dist-out 7.548 None None None EM 2.4 999.0 999.0 K 301 276 15 0 0 0 [[4, 286]] 1.0 9i9k Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9QCVK P24941 1 292 298.0 ANP:60301 ATPlike Inactive DFGin 6.495 15.807 BLAminus -144.96, -178.89 57.85, 64.57 -85.72, 49.93 282.03, 73.0 -84.65, -33.03 in-out in 9.3 Saltbr-out 4.618 HRD-in -70.41, -54.19 69.05, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.576 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -164.79, 153.04 APE9-dihe-na -68.87, 164.19 APE8-dihe-in -61.62, 153.89 APE8-rot-out 41.16 APE67-dihe-in -67.77, -23.98 -60.52, -33.7 APE12-dist-in 11.155 APE11-dist-out 6.112 APE10-dist-out 8.897 APE9-dist-in 4.078 None None None EM 2.5 999.0 999.0 K 301 292 0 0 0 0 [[4, 286]] 1.0 9qcv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOQA P24941 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.603 15.258 BLAminus -136.2, -179.04 55.17, 77.3 -91.43, 19.33 282.26, 72.55 -64.29, -18.87 in-in in 8.786 Saltbr-in 2.845 HRD-in -79.78, -53.17 69.74, 9.41 in-in-out SNCiio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 62.26, 128.16 APE9-dihe-na 76.05, 127.33 APE8-dihe-in -62.55, 137.94 APE8-rot-out 115.71 APE67-dihe-in -58.94, -23.33 -43.56, -48.15 APE12-dist-in 13.361 APE11-dist-in 9.158 APE10-dist-in 7.177 APE9-dist-in 3.246 None TPO160 TPO160 XRAY 2.15 0.201 0.234 A 301 294 3 0 0 0 [[4, 286]] 1.0 4eoq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOQC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.583 15.249 BLAminus -140.92, -177.14 51.0, 72.99 -85.26, 24.65 284.32, 71.69 -63.95, -27.55 in-in in 8.649 Saltbr-in 2.713 HRD-in -79.85, -57.3 73.26, 6.95 in-in-out SNCiio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.95, 149.43 APE9-dihe-na 70.01, 126.65 APE8-dihe-in -62.68, 144.35 APE8-rot-out 86.91 APE67-dihe-in -60.3, -23.97 -41.77, -51.35 APE12-dist-in 12.923 APE11-dist-in 9.988 APE10-dist-in 7.055 APE9-dist-in 3.18 None TPO160 TPO160 XRAY 2.15 0.201 0.234 C 301 272 24 0 0 0 [[4, 286]] 1.0 4eoq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOJA P24941 1 298 298.0 ATP:60301 ATPlike Inactive DFGin 6.671 15.377 BLAminus -134.08, 177.58 53.89, 78.08 -94.34, 17.78 277.91, 75.6 -65.2, -18.6 in-in in 8.642 Saltbr-in 2.923 HRD-in -77.88, -54.19 68.96, 13.72 in-in-out SNCiio in-out ActLoopNT-in 2.952 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -80.75, 158.76 APE9-dihe-na 76.84, 131.84 APE8-dihe-in -62.19, 141.78 APE8-rot-out 119.83 APE67-dihe-in -58.91, -24.4 -48.51, -47.68 APE12-dist-in 13.309 APE11-dist-in 9.149 APE10-dist-in 7.333 APE9-dist-in 3.214 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 A 302 294 4 0 0 0 [[4, 286]] 1.0 4eoj Homo sapiens CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOJC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.604 15.375 BLAminus -136.46, -177.75 51.71, 75.47 -89.77, 20.18 280.05, 73.98 -59.21, -28.77 in-in in 8.59 Saltbr-in 2.63 HRD-in -79.08, -54.75 70.82, 10.21 in-in-out SNCiio in-out ActLoopNT-in 2.918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.67, 155.4 APE9-dihe-na 67.15, 126.49 APE8-dihe-in -61.14, 141.64 APE8-rot-out 49.99 APE67-dihe-in -62.84, -21.66 -42.97, -49.5 APE12-dist-in 12.897 APE11-dist-in 9.826 APE10-dist-in 6.834 APE9-dist-in 3.184 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 C 302 279 17 0 0 0 [[4, 286]] 1.0 4eoj Homo sapiens CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8VQ3A P24941 1 297 298.0 A1AC4:60401 Allosteric Inactive DFGin 7.129 16.245 BLAminus -139.03, -178.82 55.37, 68.52 -84.82, 20.75 285.09, 60.51 -59.19, -33.27 in-in in 9.405 Saltbr-in 3.179 HRD-in -78.53, -53.8 72.8, -2.81 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -85.33, 113.73 APE9-dihe-na -131.15, 171.47 APE8-dihe-in -69.92, 158.21 APE8-rot-out 166.59 APE67-dihe-in -59.5, -27.96 -109.05, -50.41 APE12-dist-out 14.237 APE11-dist-in 8.79 APE10-dist-out 9.766 APE9-dist-in 5.595 None TPO160 TPO160 XRAY 1.84 0.2 0.217 A 298 297 0 0 0 0 [[4, 286]] 1.0 8vq3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8VQ4A P24941 1 297 298.0 A1AC5:60401 Allosteric Inactive DFGin 7.213 16.378 BLAminus -141.63, 178.83 59.45, 68.52 -87.1, 19.52 283.33, 69.16 -60.54, -32.28 in-in in 9.459 Saltbr-in 3.312 HRD-in -77.67, -52.1 70.93, 1.48 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 125.47 APE8-dihe-in -48.09, 139.52 APE8-rot-out 176.74 APE67-dihe-in -54.81, -27.41 -57.14, -48.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.952 None TPO160 TPO160 XRAY 1.9 0.193 0.219 A 298 294 3 0 0 3 [[4, 286]] 1.0 8vq4 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2JGZA P24941 1 288 298.0 No_ligand No_ligand Inactive DFGin 6.82 15.332 BLAminus -119.18, -174.9 51.61, 74.66 -88.82, 26.74 280.31, 63.91 -52.44, -56.56 in-out in 8.939 Saltbr-out 4.01 HRD-in -84.27, -44.78 57.22, 21.87 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.7, 145.88 APE9-dihe-na 66.31, 139.22 APE8-dihe-in -58.76, 138.9 APE8-rot-in 308.55 APE67-dihe-in -54.56, -23.64 -38.6, -60.2 APE12-dist-in 12.727 APE11-dist-in 10.569 APE10-dist-in 6.998 APE9-dist-in 3.411 None TPO160 TPO160 XRAY 2.9 0.208 0.275 A 289 288 0 0 0 0 [[4, 286]] 1.0 2jgz Homo sapiens CMGC_CDK2_HUMAN CMGC 5.6e-90 308.0 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9HIUB P24941 1 294 298.0 No_ligand No_ligand Inactive DFGin 6.138 15.551 BLAminus -148.76, -176.18 57.04, 61.27 -85.4, 17.37 274.29, 71.94 -63.88, -33.63 in-out in 8.936 Saltbr-out 3.969 HRD-in -69.53, -59.27 63.5, 5.02 out-in-out SNCoio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -161.4 APE8-rot-out 171.33 APE67-dihe-in -63.0, -40.52 -76.12, -32.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.2 999.0 999.0 B 297 285 9 0 0 5 [[4, 286]] 1.0 9hiu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9HIWB P24941 1 294 298.0 No_ligand No_ligand Inactive DFGin 6.211 15.447 BLAminus -145.37, 174.8 58.15, 65.71 -84.54, 21.5 277.88, 73.9 -62.68, -38.2 in-out in 8.996 Saltbr-out 3.949 HRD-in -66.48, -50.82 64.79, 0.22 out-in-out SNCoio in-out ActLoopNT-in 2.9 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -146.41 APE8-rot-out 166.74 APE67-dihe-in -66.55, -26.76 -98.98, -25.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.1 999.0 999.0 B 297 285 9 0 0 5 [[4, 286]] 1.0 9hiw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9HJ1B P24941 1 294 298.0 No_ligand No_ligand Inactive DFGin 6.558 15.571 BLAminus -143.27, 176.26 57.52, 63.37 -86.62, 21.76 277.25, 80.02 -66.38, -38.66 in-out in 8.901 Saltbr-out 3.724 HRD-in -62.89, -50.76 65.1, -1.08 out-in-out SNCoio in-out ActLoopNT-in 2.872 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -157.08 APE8-rot-out 169.53 APE67-dihe-in -64.07, -38.35 -94.94, -27.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 2.9 999.0 999.0 B 297 285 9 0 0 5 [[4, 286]] 1.0 9hj1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1F5QA P24941 1 298 298.0 No_ligand No_ligand Inactive DFGin 7.409 15.633 BLAminus -138.07, 171.74 53.27, 74.6 -86.39, 38.32 291.44, 74.52 -69.55, -17.11 in-in in 9.155 Saltbr-in 3.145 HRD-in -75.78, -43.37 70.11, -10.81 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -76.02, 102.77 APE9-dihe-na -78.65, -116.0 APE8-dihe-in -118.19, 147.42 APE8-rot-out 182.09 APE67-dihe-in -66.33, -17.96 -106.56, 7.87 APE12-dist-in 10.706 APE11-dist-out 6.808 APE10-dist-out 11.652 APE9-dist-out 8.859 None None None XRAY 2.5 0.234 0.278 A 298 296 2 0 0 0 [[4, 286]] 1.0 1f5q Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1F5QC P24941 1 297 298.0 No_ligand No_ligand Inactive DFGin 7.205 15.404 BLAminus -141.49, 164.85 64.2, 73.44 -87.93, 33.24 295.33, 71.82 -63.07, -25.5 in-out in 8.974 Saltbr-out 3.905 HRD-in -72.14, -50.95 71.24, 5.7 out-in-out SNCoio in-out ActLoopNT-in 2.854 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -24.69, 81.59 APE9-dihe-na -53.51, 144.38 APE8-dihe-in -123.48, 78.82 APE8-rot-out 179.54 APE67-dihe-in -62.46, -15.61 -56.76, -8.76 APE12-dist-in 10.566 APE11-dist-out 6.86 APE10-dist-out 11.839 APE9-dist-out 8.581 None None None XRAY 2.5 0.234 0.278 C 298 288 9 0 0 0 [[4, 286]] 1.0 1f5q Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1JSUA P24941 13 298 298.0 No_ligand No_ligand Inactive DFGin 6.19 16.469 BLAminus -124.79, 164.29 63.39, 89.08 -107.21, 29.25 285.85, 76.21 -70.71, -21.7 out-out out 10.235 Saltbr-out 5.128 HRD-in -73.23, -47.83 69.45, 5.62 out-in-in SNCoii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.75, 175.46 APE9-dihe-na 74.1, 131.57 APE8-dihe-in -52.14, 129.1 APE8-rot-in 292.84 APE67-dihe-in -50.28, -24.78 -35.42, -59.56 APE12-dist-in 13.438 APE11-dist-in 12.961 APE10-dist-in 7.497 APE9-dist-in 3.376 None TPO160 TPO160 XRAY 2.3 0.192 0.26 A 298 286 9 0 0 0 [[4, 286]] 1.0 1jsu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OKVA P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.444 16.078 BLAminus -120.81, -179.67 52.54, 72.67 -88.14, 19.11 277.86, 71.02 -53.88, -33.16 in-in in 8.821 Saltbr-in 2.628 HRD-in -74.58, -48.92 81.43, -17.3 in-in-out SNCiio in-out ActLoopNT-in 3.087 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -113.96, -18.23 APE9-dihe-na -58.99, -48.36 APE8-dihe-out 147.59, 117.89 APE8-rot-out 166.33 APE67-dihe-in -65.97, -14.56 -45.73, -49.07 APE12-dist-out 15.04 APE11-dist-in 11.936 APE10-dist-out 8.675 APE9-dist-in 5.151 None None None XRAY 2.4 0.201 0.278 A 298 296 0 0 0 0 [[4, 286]] 1.0 1okv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OKVC P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.774 16.283 BLAminus -143.79, -172.6 54.38, 65.18 -88.52, 20.25 276.38, 68.39 -64.37, -24.11 in-out in 9.192 Saltbr-out 4.586 HRD-in -73.64, -57.29 84.97, -6.97 out-in-out SNCoio in-out ActLoopNT-in 2.795 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -104.0, 60.23 APE9-dihe-na -130.86, 156.74 APE8-dihe-in -57.98, 139.17 APE8-rot-out 120.2 APE67-dihe-in -55.21, -29.99 -99.41, -5.27 APE12-dist-out 15.556 APE11-dist-in 10.018 APE10-dist-out 12.969 APE9-dist-out 8.857 None None None XRAY 2.4 0.201 0.278 C 298 296 0 0 0 0 [[4, 286]] 1.0 1okv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OKWA P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.484 16.126 BLAminus -137.86, 174.82 68.57, 68.02 -98.08, 26.26 277.67, 60.82 -68.53, -22.75 in-in in 8.981 Saltbr-in 3.544 HRD-in -88.52, -48.72 79.1, -22.5 in-in-out SNCiio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -78.49, 74.79 APE9-dihe-na -138.74, 155.36 APE8-dihe-in -61.05, 165.85 APE8-rot-out 184.07 APE67-dihe-in -66.44, -21.76 -100.17, -34.65 APE12-dist-out 15.341 APE11-dist-in 9.925 APE10-dist-out 9.606 APE9-dist-out 6.14 None None None XRAY 2.5 0.175 0.253 A 298 296 0 0 0 0 [[4, 286]] 1.0 1okw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OKWC P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.417 15.953 BLAminus -139.6, 173.1 64.79, 70.69 -95.36, 23.49 272.31, 64.24 -64.28, -22.11 in-in in 8.901 Saltbr-in 3.267 HRD-in -77.15, -48.85 78.53, -9.81 in-in-out SNCiio in-out ActLoopNT-in 2.987 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -119.07, 84.55 APE9-dihe-na -93.96, -176.51 APE8-dihe-in -80.28, 151.09 APE8-rot-out 185.01 APE67-dihe-in -56.22, -29.25 -111.15, -2.69 APE12-dist-out 15.272 APE11-dist-in 9.091 APE10-dist-out 10.956 APE9-dist-out 6.866 None None None XRAY 2.5 0.175 0.253 C 298 296 0 0 0 0 [[4, 286]] 1.0 1okw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OL1A P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.408 15.545 BLAminus -140.82, 172.23 59.17, 80.76 -93.23, 29.91 271.28, 60.47 -67.99, -40.25 in-in in 8.408 Saltbr-in 2.915 HRD-in -95.64, -45.73 68.37, -0.63 in-in-out SNCiio in-out ActLoopNT-in 3.012 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioi APE10-dihe-na -101.47, 3.34 APE9-dihe-na -94.64, -32.92 APE8-dihe-out 139.88, 160.77 APE8-rot-in 283.05 APE67-dihe-in -59.35, -30.39 -95.92, -51.95 APE12-dist-out 15.071 APE11-dist-in 11.17 APE10-dist-out 8.139 APE9-dist-in 4.921 None None None XRAY 2.9 0.209 0.284 A 298 296 0 0 0 0 [[4, 286]] 1.0 1ol1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OL1C P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.699 15.724 BLAminus -161.99, 173.47 66.17, 68.99 -93.37, 29.69 275.55, 55.92 -61.88, -36.75 in-in in 8.896 Saltbr-in 3.081 HRD-in -78.75, -57.42 81.19, 0.27 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioi APE10-dihe-na 61.11, -103.73 APE9-dihe-na 48.89, -112.15 APE8-dihe-out -157.24, -69.82 APE8-rot-out 2.59 APE67-dihe-out -45.45, -36.33 96.74, -73.48 APE12-dist-in 13.453 APE11-dist-in 10.076 APE10-dist-out 8.134 APE9-dist-in 4.879 None None None XRAY 2.9 0.209 0.284 C 298 296 0 0 0 0 [[4, 286]] 1.0 1ol1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OL2A P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.452 15.178 BLAminus -120.84, -174.45 48.91, 74.14 -88.83, 27.64 281.83, 69.44 -74.49, -21.64 in-in in 8.25 Saltbr-in 3.137 HRD-in -82.7, -44.63 87.48, -37.81 in-in-out SNCiio in-out ActLoopNT-in 2.741 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -104.1, 6.86 APE9-dihe-na -97.06, -44.6 APE8-dihe-out 147.22, 120.74 APE8-rot-out 174.14 APE67-dihe-in -64.66, -29.42 -59.01, -48.31 APE12-dist-out 14.923 APE11-dist-in 11.799 APE10-dist-out 8.677 APE9-dist-in 5.483 None None None XRAY 2.6 0.194 0.29 A 298 296 0 0 0 0 [[4, 286]] 1.0 1ol2 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OL2C P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.385 15.626 BLAminus -136.02, -168.49 52.37, 72.81 -90.41, 24.94 279.14, 62.11 -65.28, -29.14 in-in in 8.504 Saltbr-in 2.675 HRD-in -67.99, -46.22 80.57, -8.38 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -94.09, 71.79 APE9-dihe-na -107.39, 168.28 APE8-dihe-in -60.83, 133.72 APE8-rot-out 71.55 APE67-dihe-in -48.15, -33.44 -102.75, -3.43 APE12-dist-out 15.436 APE11-dist-in 9.617 APE10-dist-out 13.093 APE9-dist-out 8.703 None None None XRAY 2.6 0.194 0.29 C 298 296 0 0 0 0 [[4, 286]] 1.0 1ol2 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1URCA P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.512 14.981 BLAminus -129.95, 175.56 55.15, 83.89 -97.6, 32.32 291.84, 63.51 -71.22, -27.23 in-in in 8.341 Saltbr-in 3.061 HRD-in -94.24, -49.78 87.01, -13.05 in-in-out SNCiio in-out ActLoopNT-in 2.849 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oioo APE10-dihe-na -127.29, -40.73 APE9-dihe-na -65.24, -160.23 APE8-dihe-in -82.59, 155.77 APE8-rot-out 198.85 APE67-dihe-out 76.94, -57.2 -81.24, -148.21 APE12-dist-out 14.773 APE11-dist-in 11.005 APE10-dist-out 8.201 APE9-dist-out 6.666 None None None XRAY 2.6 0.177 0.254 A 298 296 0 0 0 0 [[4, 286]] 1.0 1urc Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1URCC P24941 1 297 298.0 No_ligand No_ligand Inactive DFGin 6.524 15.349 BLAminus -139.3, 168.34 67.82, 71.56 -90.12, 30.22 284.71, 64.0 -56.18, -36.82 in-in in 8.248 Saltbr-in 3.017 HRD-in -76.88, -54.17 79.16, -8.55 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -115.87, 126.59 APE9-dihe-na -47.68, 173.83 APE8-dihe-in -109.65, 161.85 APE8-rot-in 305.52 APE67-dihe-in -50.71, -33.17 -102.69, -32.98 APE12-dist-out 15.057 APE11-dist-in 10.918 APE10-dist-in 7.87 APE9-dist-out 6.603 None None None XRAY 2.6 0.177 0.254 C 298 297 0 0 0 0 [[4, 286]] 1.0 1urc Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2V22A P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.459 15.492 BLAminus -132.44, 178.14 60.5, 75.27 -95.35, 22.95 275.6, 72.86 -49.4, -38.54 in-in in 8.576 Saltbr-in 2.78 HRD-in -76.19, -55.04 83.89, -15.21 in-in-out SNCiio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -86.69, 68.29 APE9-dihe-na -152.82, 33.68 APE8-dihe-out 63.56, 145.92 APE8-rot-out 217.61 APE67-dihe-in -67.06, -9.7 -100.44, -48.4 APE12-dist-out 14.865 APE11-dist-in 11.579 APE10-dist-out 9.334 APE9-dist-in 5.28 None None None XRAY 2.6 0.174 0.277 A 298 296 0 0 0 0 [[4, 286]] 1.0 2v22 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2V22C P24941 1 297 298.0 No_ligand No_ligand Inactive DFGin 6.331 15.479 BLAminus -146.83, 177.32 52.95, 76.41 -87.8, 21.74 277.38, 65.05 -51.11, -39.67 in-in in 8.474 Saltbr-in 3.432 HRD-in -64.56, -46.03 68.73, -15.43 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -107.38, 80.17 APE9-dihe-na -132.24, 155.09 APE8-dihe-in -62.03, 145.84 APE8-rot-out 167.13 APE67-dihe-in -60.96, -28.05 -89.82, -49.35 APE12-dist-out 15.419 APE11-dist-in 10.033 APE10-dist-out 9.27 APE9-dist-in 5.726 None None None XRAY 2.6 0.174 0.277 C 298 297 0 0 0 0 [[4, 286]] 1.0 2v22 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WFYA P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.469 15.809 BLAminus -129.75, 175.75 62.42, 74.14 -93.98, 21.08 281.46, 65.37 -60.72, -22.48 in-out in 9.061 Saltbr-out 6.379 HRD-in -69.87, -51.87 88.77, -25.86 out-in-out SNCoio in-out ActLoopNT-in 2.823 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -104.24, -15.67 APE9-dihe-na -94.73, 79.23 APE8-dihe-out 36.75, 114.18 APE8-rot-out 202.36 APE67-dihe-in -72.54, -16.11 -61.07, -35.76 APE12-dist-out 14.976 APE11-dist-in 11.914 APE10-dist-out 9.009 APE9-dist-out 6.349 None None None XRAY 2.53 0.195 0.259 A 298 296 0 0 0 0 [[4, 286]] 1.0 2wfy Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WFYC P24941 1 297 298.0 No_ligand No_ligand Inactive DFGin 6.679 16.186 BLAminus -141.19, 179.78 59.71, 73.1 -96.77, 21.07 273.92, 71.63 -56.41, -28.59 in-out in 8.985 Saltbr-out 4.526 HRD-in -70.6, -53.24 84.65, -12.77 out-in-out SNCoio in-out ActLoopNT-in 2.982 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -110.71, 8.78 APE9-dihe-na -67.27, 116.94 APE8-dihe-in -40.1, 145.37 APE8-rot-out 91.78 APE67-dihe-in -63.11, -28.51 -75.52, -20.96 APE12-dist-out 15.515 APE11-dist-in 10.104 APE10-dist-out 11.621 APE9-dist-out 6.75 None None None XRAY 2.53 0.195 0.259 C 298 297 0 0 0 0 [[4, 286]] 1.0 2wfy Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WHBA P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.286 15.171 BLAminus -121.93, 168.73 63.84, 89.73 -110.71, 19.58 281.17, 65.75 -54.28, -25.03 in-in in 8.639 Saltbr-in 3.308 HRD-in -68.38, -52.89 83.41, -8.21 in-in-out SNCiio in-out ActLoopNT-in 3.066 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioi APE10-dihe-na -118.47, 48.49 APE9-dihe-na -148.16, 52.77 APE8-dihe-out 65.52, 155.0 APE8-rot-in 283.14 APE67-dihe-in -46.44, -19.45 -113.22, -61.36 APE12-dist-out 14.786 APE11-dist-in 11.988 APE10-dist-out 8.793 APE9-dist-in 5.526 None None None XRAY 2.9 0.189 0.264 A 298 296 0 0 0 0 [[4, 286]] 1.0 2whb Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WHBC P24941 1 297 298.0 No_ligand No_ligand Inactive DFGin 6.502 15.421 BLAminus -146.01, -173.35 41.98, 75.41 -92.68, 20.49 281.39, 65.9 -59.19, -37.47 in-in in 8.556 Saltbr-in 3.459 HRD-in -71.29, -45.65 74.78, -17.63 in-in-out SNCiio in-out ActLoopNT-in 2.979 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioi APE10-dihe-na -98.69, 73.38 APE9-dihe-na -150.46, 35.88 APE8-dihe-out 58.38, 135.63 APE8-rot-in 256.16 APE67-dihe-in -49.67, -33.51 -102.65, -53.6 APE12-dist-out 14.904 APE11-dist-in 10.857 APE10-dist-out 9.748 APE9-dist-in 5.97 None None None XRAY 2.9 0.189 0.264 C 298 297 0 0 0 0 [[4, 286]] 1.0 2whb Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5IF1A P24941 1 298 298.0 No_ligand No_ligand Inactive DFGin 6.094 15.381 BLAminus -137.43, -174.52 43.73, 86.52 -101.84, 23.59 285.83, 70.6 -54.56, -38.41 in-in in 8.573 Saltbr-in 2.958 HRD-in -83.82, -51.99 75.85, -16.4 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -153.82, 139.29 APE9-dihe-na -47.73, 145.98 APE8-dihe-in -46.95, 154.13 APE8-rot-out 198.64 APE67-dihe-in -68.44, -24.11 -52.75, -43.3 APE12-dist-in 11.049 APE11-dist-out 6.129 APE10-dist-out 8.993 APE9-dist-in 3.976 None None None XRAY 2.61 0.19 0.236 A 298 298 0 0 0 0 [[4, 286]] 1.0 5if1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5IF1C P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.211 15.36 BLAminus -139.2, -174.49 53.76, 79.01 -103.15, 18.84 280.18, 72.88 -48.24, -37.81 in-in in 8.525 Saltbr-in 2.776 HRD-in -76.93, -53.21 80.62, -3.93 in-in-out SNCiio in-out ActLoopNT-in 2.99 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -105.55, 40.53 APE9-dihe-na -54.61, 119.45 APE8-dihe-out -116.22, -167.37 APE8-rot-out 184.29 APE67-dihe-in -73.46, -22.29 -91.2, -34.06 APE12-dist-in 12.629 APE11-dist-in 9.942 APE10-dist-out 8.925 APE9-dist-out 6.377 None None None XRAY 2.61 0.19 0.236 C 298 296 0 0 0 0 [[4, 286]] 1.0 5if1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6P3WA P24941 1 298 298.0 No_ligand No_ligand Inactive DFGin 6.383 15.256 BLAminus -139.11, 178.96 55.88, 76.9 -95.56, 29.89 282.66, 70.84 -65.96, -13.03 in-in in 8.964 Saltbr-in 3.117 HRD-in -81.25, -53.11 69.58, 7.71 in-in-out SNCiio in-out ActLoopNT-in 2.794 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -154.18, 150.8 APE9-dihe-na -61.6, 156.17 APE8-dihe-in -59.43, 155.66 APE8-rot-out 186.9 APE67-dihe-in -57.18, -24.62 -51.59, -46.89 APE12-dist-in 11.107 APE11-dist-out 6.246 APE10-dist-out 9.163 APE9-dist-in 3.944 None None None XRAY 2.54 0.2 0.237 A 298 298 0 0 0 0 [[4, 286]] 1.0 6p3w Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6P3WC P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.343 15.754 BLAminus -139.35, 175.72 58.19, 71.13 -90.52, 28.64 281.02, 70.32 -63.15, -27.73 in-in in 9.237 Saltbr-in 3.241 HRD-in -82.0, -55.09 71.8, 0.84 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.51, 158.31 APE9-dihe-na -67.03, 164.28 APE8-dihe-in -53.2, 147.11 APE8-rot-in 323.66 APE67-dihe-in -58.81, -32.57 -51.42, -40.12 APE12-dist-in 11.385 APE11-dist-out 6.698 APE10-dist-out 9.732 APE9-dist-in 4.166 None None None XRAY 2.54 0.2 0.237 C 298 296 0 0 0 0 [[4, 286]] 1.0 6p3w Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7B5LL P24941 13 298 298.0 No_ligand No_ligand Inactive DFGin 6.668 16.777 BLAminus -159.37, -170.5 58.23, 65.17 -90.27, 25.66 278.63, 99.6 -75.03, -21.38 out-out out 10.414 Saltbr-out 4.901 HRD-in -83.03, -61.13 65.98, 9.04 out-in-out SNCoio in-out ActLoopNT-in 3.401 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -120.72, -152.25 APE9-dihe-na -52.91, -65.47 APE8-dihe-in -175.87, 143.72 APE8-rot-out 174.23 APE67-dihe-in -69.97, -22.68 -55.73, -38.14 APE12-dist-in 13.204 APE11-dist-in 10.359 APE10-dist-out 8.748 APE9-dist-in 3.249 None TPO160 TPO160 EM 3.8 999.0 999.0 L 298 284 11 0 0 2 [[4, 286]] 1.0 7b5l Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7B5RL P24941 13 298 298.0 No_ligand No_ligand Inactive DFGin 6.915 16.95 BLAminus -161.78, -169.14 57.49, 63.4 -93.04, 29.37 272.67, 109.31 -77.5, -17.83 out-out out 10.288 Saltbr-out 4.883 HRD-in -82.33, -61.79 67.76, 6.88 out-in-out SNCoio in-out ActLoopNT-in 3.119 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -126.01, -160.31 APE9-dihe-na -51.6, -65.48 APE8-dihe-in -176.61, 148.68 APE8-rot-out 187.15 APE67-dihe-in -75.42, -28.29 -61.57, -20.14 APE12-dist-in 13.445 APE11-dist-in 9.73 APE10-dist-out 9.18 APE9-dist-in 3.308 None TPO160 TPO160 EM 3.8 999.0 999.0 L 298 284 11 0 0 2 [[4, 286]] 1.0 7b5r Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8ROZA P24941 1 298 298.0 No_ligand No_ligand Inactive DFGin 6.665 15.45 BLAminus -146.85, -178.58 57.04, 63.1 -84.71, 23.05 276.75, 81.02 -63.7, -33.06 in-out in 9.074 Saltbr-out 5.335 HRD-in -64.84, -52.8 64.14, 6.42 out-in-in SNCoii in-in ActLoopNT-in 2.633 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.19, -66.83 APE9-dihe-na -78.06, 149.53 APE8-dihe-in -57.99, 137.61 APE8-rot-in 275.96 APE67-dihe-in -65.57, -29.26 -55.51, -35.38 APE12-dist-in 12.972 APE11-dist-in 10.877 APE10-dist-in 6.79 APE9-dist-in 3.505 None PTR15,TPO160 PTR15,TPO160 EM 2.7 999.0 999.0 A 298 298 0 0 0 0 [[4, 286]] 1.0 8roz Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9D0WC P24941 1 298 298.0 No_ligand No_ligand Inactive DFGin 6.71 15.607 BLAminus -142.76, 174.08 59.36, 65.83 -80.37, 18.14 274.15, 77.52 -62.17, -35.05 in-out in 9.166 Saltbr-out 3.829 HRD-in -67.33, -50.6 58.18, 14.57 out-in-in SNCoii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.57, 167.48 APE9-dihe-na 66.76, 152.47 APE8-dihe-in -65.46, 154.58 APE8-rot-in 313.38 APE67-dihe-in -69.23, -14.94 -60.37, -40.8 APE12-dist-in 13.505 APE11-dist-in 12.137 APE10-dist-in 7.413 APE9-dist-in 3.455 None TPO160 TPO160 EM 2.95 999.0 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 9d0w Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5UQ2A P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 6.558 15.673 BLAminus -135.72, 176.46 56.22, 78.5 -94.75, 31.43 279.25, 69.13 -68.67, -32.7 in-in in 9.307 Saltbr-in 2.963 HRD-in -85.45, -45.85 64.92, 5.26 in-in-out SNCiio in-out ActLoopNT-in 2.771 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.62, -45.62 APE9-dihe-na -157.2, 156.57 APE8-dihe-in -50.52, 138.9 APE8-rot-out 173.02 APE67-dihe-in -53.88, -32.0 -45.73, -36.16 APE12-dist-in 12.023 APE11-dist-in 8.869 APE10-dist-in 7.372 APE9-dist-in 4.185 None None None XRAY 2.7 0.218 0.275 A 301 296 0 0 0 0 [[4, 286]] 1.0 5uq2 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5UQ3A P24941 19 292 298.0 No_ligand No_ligand Inactive DFGin 6.345 16.412 BLAminus -141.59, 169.76 60.28, 73.58 -86.8, 7.95 283.62, 89.48 -47.73, -37.18 out-in out 10.24 Saltbr-in 3.29 HRD-in -69.92, -53.79 58.55, 18.19 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -123.76, -74.2 APE9-dihe-na -86.53, 177.66 APE8-dihe-in -97.37, 112.1 APE8-rot-in 321.43 APE67-dihe-out -59.51, -20.87 56.52, -115.63 APE12-dist-in 13.196 APE11-dist-in 10.702 APE10-dist-in 7.789 APE9-dist-in 3.195 None None None XRAY 3.6 0.251 0.324 A 301 270 19 0 0 0 [[4, 286]] 1.0 5uq3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9QCXK P24941 1 292 298.0 No_ligand No_ligand Inactive DFGin 6.719 16.041 BLAminus -144.83, 178.78 57.4, 64.51 -84.56, 50.23 281.94, 71.88 -85.61, -30.32 in-in in 9.27 Saltbr-in 3.236 HRD-in -67.06, -51.02 68.85, 2.16 in-in-out SNCiio in-out ActLoopNT-in 2.595 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -167.43, 154.34 APE9-dihe-na -64.57, 162.43 APE8-dihe-in -64.83, 167.28 APE8-rot-out 196.35 APE67-dihe-in -64.39, -23.47 -61.67, -44.4 APE12-dist-in 10.937 APE11-dist-out 5.963 APE10-dist-out 8.949 APE9-dist-in 3.98 None None None EM 2.6 999.0 999.0 K 301 292 0 0 0 0 [[4, 286]] 1.0 9qcx Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6SG4A P24941 28 294 298.0 No_ligand No_ligand Inactive DFGin 6.287 15.272 BLAminus -142.64, -177.22 52.35, 74.31 -90.44, 26.74 283.94, 75.05 -68.52, -27.31 in-out in 8.328 Saltbr-out 3.836 HRD-in -89.89, -55.83 73.82, 12.09 out-in-in SNCoii in-in ActLoopNT-in 3.094 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.38, 167.08 APE9-dihe-na 73.43, 135.34 APE8-dihe-in -50.66, 135.8 APE8-rot-in 300.95 APE67-dihe-in -63.18, -27.15 -46.65, -49.09 APE12-dist-in 13.476 APE11-dist-in 12.358 APE10-dist-in 7.297 APE9-dist-in 3.221 None TPO160 TPO160 XRAY 2.43 0.203 0.251 A 302 262 29 0 0 0 [[4, 286]] 1.0 6sg4 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6SG4C P24941 29 295 298.0 No_ligand No_ligand Inactive DFGin 6.267 16.249 BLAminus -137.43, 175.83 54.02, 83.17 -94.69, 27.17 280.38, 64.22 -59.95, -51.33 out-out out 13.669 Saltbr-out 13.339 HRD-in -70.61, -65.73 80.25, 9.94 out-in-in SNCoii in-in ActLoopNT-in 3.113 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.33, -55.22 APE9-dihe-na -67.84, 151.02 APE8-dihe-in -58.58, 141.84 APE8-rot-in 311.32 APE67-dihe-in -64.58, -30.99 -51.04, -45.77 APE12-dist-in 13.48 APE11-dist-in 12.252 APE10-dist-in 6.83 APE9-dist-in 3.537 None TPO160 TPO160 XRAY 2.43 0.203 0.251 C 302 261 31 0 0 0 [[4, 286]] 1.0 6sg4 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H24A P24941 1 293 298.0 No_ligand No_ligand Inactive DFGin 6.37 15.441 BLAminus -149.05, 176.13 58.55, 82.71 -98.93, 22.4 284.12, 70.53 -57.88, -40.84 in-out in 8.905 Saltbr-out 3.678 HRD-in -79.24, -45.57 66.77, 15.64 out-in-in SNCoii in-in ActLoopNT-in 2.986 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.68, 132.36 APE9-dihe-na 80.91, 130.55 APE8-dihe-in -56.75, 124.45 APE8-rot-in 291.68 APE67-dihe-in -59.21, -22.16 -34.29, -51.02 APE12-dist-in 13.068 APE11-dist-in 9.844 APE10-dist-in 7.943 APE9-dist-in 3.323 None TPO160 TPO160 XRAY 2.5 0.212 0.27 A 303 293 0 0 0 0 [[4, 286]] 1.0 1h24 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOPA P24941 1 297 298.0 1RO:60301 Type1 Inactive DFGin 6.723 14.906 BLAminus -142.23, 176.95 53.72, 81.49 -94.48, 24.24 283.28, 65.78 -63.26, -27.47 in-in in 8.449 Saltbr-in 2.822 HRD-in -80.96, -51.6 68.18, 9.66 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 70.66, 113.36 APE9-dihe-na 74.68, 127.54 APE8-dihe-in -59.54, 139.46 APE8-rot-out 59.13 APE67-dihe-in -58.69, -27.51 -46.09, -46.99 APE12-dist-in 13.181 APE11-dist-in 11.447 APE10-dist-in 7.369 APE9-dist-in 3.234 Q131E TPO160 TPO160 XRAY 1.99 0.217 0.241 A 300 295 2 0 0 0 [[4, 286]] 1.0 4eop Homo sapiens CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOPC P24941 1 296 298.0 1RO:60301 Type1 Inactive DFGin 6.659 14.989 BLAminus -141.59, -178.41 53.15, 82.16 -98.68, 23.27 279.66, 67.46 -60.45, -30.01 in-in in 8.475 Saltbr-in 2.577 HRD-in -79.11, -56.1 69.98, 13.7 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.71, 145.25 APE9-dihe-na 75.85, 128.83 APE8-dihe-in -51.66, 132.74 APE8-rot-out 165.33 APE67-dihe-in -57.08, -27.57 -43.54, -49.82 APE12-dist-in 13.046 APE11-dist-in 9.735 APE10-dist-in 7.394 APE9-dist-in 3.113 Q131E TPO160 TPO160 XRAY 1.99 0.217 0.241 C 300 296 0 0 0 0 [[4, 286]] 1.0 4eop Homo sapiens CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOIC P24941 1 296 298.0 1RO:60301 Type1 Inactive DFGin 6.532 15.052 BLAminus -147.54, 173.29 55.92, 74.44 -88.6, 22.51 283.95, 67.62 -63.63, -26.66 in-in in 8.392 Saltbr-in 2.597 HRD-in -75.18, -52.68 66.93, 12.44 in-in-out SNCiio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -61.02, 154.87 APE9-dihe-na 73.94, 127.83 APE8-dihe-in -53.4, 131.61 APE8-rot-out 162.43 APE67-dihe-in -60.65, -19.15 -42.11, -50.1 APE12-dist-in 12.995 APE11-dist-in 9.392 APE10-dist-in 7.138 APE9-dist-in 3.207 K89D,Q131E TPO160 TPO160 XRAY 2.0 0.215 0.234 C 299 296 0 0 0 0 [[4, 286]] 1.0 4eoi Homo sapiens CMGC_CDK2_HUMAN CMGC 6.9e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PKDA P24941 1 296 298.0 UCN:60410 Type1 Inactive DFGin 6.575 15.387 BLAminus -133.85, 171.83 54.3, 84.1 -93.29, 24.7 280.02, 73.48 -58.68, -37.61 in-out in 8.802 Saltbr-out 3.66 HRD-in -78.55, -55.12 71.6, 20.95 out-in-in SNCoii in-in ActLoopNT-in 3.033 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.48, 136.15 APE9-dihe-na 78.94, 132.36 APE8-dihe-in -52.7, 137.01 APE8-rot-in 296.12 APE67-dihe-in -63.8, -19.34 -42.25, -50.85 APE12-dist-in 13.145 APE11-dist-in 10.217 APE10-dist-in 7.647 APE9-dist-in 3.38 None TPO160 TPO160 XRAY 2.3 0.218 0.268 A 297 296 0 0 0 0 [[4, 286]] 1.0 1pkd Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5LMKC P24941 1 296 298.0 6ZK:60301 Type1 Inactive DFGin 6.705 15.05 BLAminus -133.26, 168.47 55.4, 88.46 -97.71, 24.83 283.38, 67.26 -61.17, -33.57 in-in in 8.381 Saltbr-in 2.721 HRD-in -79.79, -56.45 69.59, 15.54 in-in-out SNCiio in-out ActLoopNT-in 3.041 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.62, 152.55 APE9-dihe-na 64.49, 124.67 APE8-dihe-in -64.32, 149.59 APE8-rot-out 199.23 APE67-dihe-in -63.12, -14.1 -44.88, -52.53 APE12-dist-in 12.806 APE11-dist-in 10.06 APE10-dist-in 6.819 APE9-dist-in 3.354 None TPO160 TPO160 XRAY 2.4 0.213 0.249 C 297 265 31 0 0 0 [[4, 286]] 1.0 5lmk Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EORA P24941 1 297 298.0 4SP:60301 Type1 Inactive DFGin 6.882 15.033 BLAminus -134.35, 175.73 52.6, 78.13 -90.64, 21.49 277.96, 74.78 -65.84, -25.49 in-out in 8.397 Saltbr-out 4.415 HRD-in -78.57, -52.47 67.64, 16.68 out-in-in SNCoii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -52.36, 151.62 APE9-dihe-na 75.68, 126.45 APE8-dihe-in -53.52, 134.61 APE8-rot-in 299.42 APE67-dihe-in -64.87, -24.77 -45.32, -44.73 APE12-dist-in 13.316 APE11-dist-in 9.486 APE10-dist-in 7.268 APE9-dist-in 3.338 None TPO160 TPO160 XRAY 2.2 0.222 0.245 A 298 293 4 0 0 0 [[4, 286]] 1.0 4eor Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EORC P24941 1 294 298.0 4SP:60301 Type1 Inactive DFGin 6.781 14.95 BLAminus -138.63, 178.48 45.83, 76.13 -84.97, 25.42 283.82, 70.0 -63.08, -30.05 in-in in 8.545 Saltbr-in 2.705 HRD-in -80.46, -52.24 65.94, 14.93 in-in-out SNCiio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.75, 149.39 APE9-dihe-na 67.36, 128.22 APE8-dihe-in -66.22, 148.97 APE8-rot-out 182.23 APE67-dihe-in -56.76, -22.19 -48.62, -53.23 APE12-dist-in 12.889 APE11-dist-in 9.84 APE10-dist-in 7.025 APE9-dist-in 3.22 None TPO160 TPO160 XRAY 2.2 0.222 0.245 C 298 270 24 0 0 0 [[4, 286]] 1.0 4eor Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1FVVA P24941 1 298 298.0 107:501 Type1 Inactive DFGin 6.658 14.901 BLAminus -137.65, 171.94 57.98, 81.02 -95.75, 36.92 284.57, 57.51 -69.65, -41.19 in-in in 8.048 Saltbr-in 2.87 HRD-in -77.21, -53.67 74.56, -7.57 in-in-out SNCiio in-out ActLoopNT-in 2.711 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.03, -46.72 APE9-dihe-na -50.79, 166.23 APE8-dihe-in -64.52, 158.74 APE8-rot-out 198.27 APE67-dihe-in -53.47, -26.59 -84.97, -53.54 APE12-dist-in 13.444 APE11-dist-in 12.405 APE10-dist-in 7.041 APE9-dist-in 4.494 None None None XRAY 2.8 0.21 0.26 A 298 298 0 0 0 0 [[4, 286]] 1.0 1fvv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1FVVC P24941 1 298 298.0 107:601 Type1 Inactive DFGin 6.361 14.899 BLAminus -137.03, 174.12 49.53, 89.09 -101.6, 27.15 286.0, 65.52 -55.32, -31.13 in-in in 8.256 Saltbr-in 2.958 HRD-in -78.2, -48.22 68.63, -7.2 in-in-out SNCiio in-out ActLoopNT-in 2.801 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiii APE10-dihe-na -115.1, -27.85 APE9-dihe-na -49.77, 137.89 APE8-dihe-in -57.38, 118.15 APE8-rot-out 181.94 APE67-dihe-in -55.57, -48.11 -37.79, -50.26 APE12-dist-out 14.006 APE11-dist-in 12.366 APE10-dist-in 7.566 APE9-dist-in 4.312 None None None XRAY 2.8 0.21 0.26 C 298 298 0 0 0 0 [[4, 286]] 1.0 1fvv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C5NA P24941 1 296 298.0 CK8:1297 Type1 Inactive DFGin 6.462 15.333 BLAminus -134.71, 179.52 48.73, 86.34 -97.55, 25.19 275.89, 67.63 -63.89, -28.59 in-in in 8.543 Saltbr-in 2.861 HRD-in -83.74, -45.86 67.31, -5.85 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -100.4, 27.23 APE9-dihe-na -97.0, -7.31 APE8-dihe-out 101.7, 140.58 APE8-rot-out 225.76 APE67-dihe-in -62.0, -24.64 -95.08, -50.02 APE12-dist-out 14.274 APE11-dist-in 11.452 APE10-dist-out 8.969 APE9-dist-in 5.21 None None None XRAY 2.1 0.178 0.259 A 298 296 0 0 0 0 [[4, 286]] 1.0 2c5n Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C5NC P24941 1 297 298.0 CK8:1298 Type1 Inactive DFGin 6.63 15.437 BLAminus -141.11, 171.58 67.92, 76.41 -96.67, 28.48 283.19, 65.37 -68.12, -31.46 in-in in 8.555 Saltbr-in 2.627 HRD-in -73.82, -54.83 87.12, -13.53 in-in-out SNCiio in-out ActLoopNT-in 2.951 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -121.38, 99.53 APE9-dihe-na -160.5, -177.06 APE8-dihe-in -68.95, 135.12 APE8-rot-out 74.74 APE67-dihe-in -60.97, -29.13 -104.2, -8.66 APE12-dist-out 16.291 APE11-dist-in 10.261 APE10-dist-out 12.525 APE9-dist-out 9.045 None None None XRAY 2.1 0.178 0.259 C 298 297 0 0 0 0 [[4, 286]] 1.0 2c5n Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C5OA P24941 1 296 298.0 CK2:1297 Type1 Inactive DFGin 6.494 15.29 BLAminus -137.74, 173.02 58.56, 80.78 -92.88, 19.82 283.21, 65.89 -51.26, -36.47 in-in in 8.62 Saltbr-in 3.023 HRD-in -83.52, -43.57 76.97, -18.17 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -99.47, 35.52 APE9-dihe-na -88.97, 170.31 APE8-dihe-in -57.41, 159.51 APE8-rot-out 226.24 APE67-dihe-in -53.95, -30.16 -94.63, -49.34 APE12-dist-out 14.686 APE11-dist-in 11.359 APE10-dist-out 9.793 APE9-dist-in 5.599 None None None XRAY 2.1 0.197 0.256 A 298 296 0 0 0 0 [[4, 286]] 1.0 2c5o Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C5OC P24941 1 297 298.0 CK2:1298 Type1 Inactive DFGin 6.476 15.429 BLAminus -144.63, 177.97 57.45, 72.75 -89.52, 20.98 280.55, 69.4 -66.45, -25.41 in-in in 8.538 Saltbr-in 3.095 HRD-in -84.92, -44.81 82.92, -18.25 in-in-out SNCiio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -95.84, 39.31 APE9-dihe-na -90.01, 169.5 APE8-dihe-in -56.49, 156.39 APE8-rot-out 222.88 APE67-dihe-in -60.8, -32.24 -97.54, -42.65 APE12-dist-out 14.878 APE11-dist-in 11.424 APE10-dist-out 9.966 APE9-dist-in 5.682 None None None XRAY 2.1 0.197 0.256 C 298 297 0 0 0 0 [[4, 286]] 1.0 2c5o Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C5VA P24941 1 296 298.0 CK4:1297 Type1 Inactive DFGin 6.4 15.573 BLAminus -152.6, 173.72 50.46, 81.89 -96.59, 19.88 274.06, 74.93 -61.32, -20.24 in-in in 8.811 Saltbr-in 2.869 HRD-in -75.99, -60.23 91.66, -18.06 in-in-out SNCiio in-out ActLoopNT-in 2.783 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -109.47, 18.26 APE9-dihe-na -77.73, -92.42 APE8-dihe-in -159.97, 141.7 APE8-rot-out 178.35 APE67-dihe-in -63.79, -32.5 -86.3, -47.27 APE12-dist-out 14.533 APE11-dist-in 11.488 APE10-dist-out 10.2 APE9-dist-out 6.251 None None None XRAY 2.9 0.175 0.282 A 298 296 0 0 0 0 [[4, 286]] 1.0 2c5v Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C5VC P24941 1 296 298.0 CK4:1297 Type1 Inactive DFGin 6.33 15.522 BLAminus -154.23, 176.87 55.11, 76.96 -96.71, 24.34 275.08, 71.53 -59.6, -22.02 in-in in 8.621 Saltbr-in 3.132 HRD-in -61.51, -55.66 92.96, -22.41 in-in-out SNCiio in-out ActLoopNT-in 2.986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -115.04, 15.2 APE9-dihe-na -65.4, -115.45 APE8-dihe-in -142.09, 152.22 APE8-rot-out 184.7 APE67-dihe-in -64.96, -41.68 -88.36, -39.06 APE12-dist-out 14.221 APE11-dist-in 10.918 APE10-dist-out 10.336 APE9-dist-out 6.492 None None None XRAY 2.9 0.175 0.282 C 298 296 0 0 0 0 [[4, 286]] 1.0 2c5v Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C5XA P24941 1 296 298.0 MTW:1297 Type1 Inactive DFGin 6.456 15.49 BLAminus -147.14, 173.63 64.88, 81.13 -99.82, 31.9 280.01, 44.97 -72.1, -29.12 in-in in 8.351 Saltbr-in 3.421 HRD-in -95.4, -39.54 63.25, -15.18 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oioi APE10-dihe-na -84.91, 67.81 APE9-dihe-na -125.9, -36.28 APE8-dihe-out 122.49, 156.35 APE8-rot-out 176.62 APE67-dihe-out 57.5, -47.85 -96.74, -115.33 APE12-dist-out 14.12 APE11-dist-in 11.374 APE10-dist-out 9.051 APE9-dist-in 5.854 None None None XRAY 2.9 0.203 0.264 A 298 296 0 0 0 0 [[4, 286]] 1.0 2c5x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C5XC P24941 1 296 298.0 MTW:1297 Type1 Inactive DFGin 6.478 15.536 BLAminus -137.8, 171.4 74.5, 81.98 -98.98, 18.7 276.64, 65.26 -59.32, -18.19 in-in in 8.872 Saltbr-in 3.325 HRD-in -99.79, -42.03 69.9, -20.79 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -106.41, 92.79 APE9-dihe-na -94.18, -148.42 APE8-dihe-in -127.45, 167.08 APE8-rot-out 106.98 APE67-dihe-in -21.73, -45.61 -109.0, -46.95 APE12-dist-out 14.979 APE11-dist-in 9.273 APE10-dist-out 11.28 APE9-dist-out 6.942 None None None XRAY 2.9 0.203 0.264 C 298 296 0 0 0 0 [[4, 286]] 1.0 2c5x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2I40A P24941 1 297 298.0 BLZ:301 Type1 Inactive DFGin 6.501 15.32 BLAminus -136.92, 178.32 54.65, 74.51 -89.47, 33.14 288.96, 69.44 -65.33, -27.4 in-in in 8.719 Saltbr-in 2.817 HRD-in -76.77, -57.06 80.86, -11.7 in-in-out SNCiio in-out ActLoopNT-in 2.789 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnii APE10-dihe-na 999.0, -92.23 APE9-dihe-na -60.69, 145.56 APE8-dihe-in -55.35, 148.14 APE8-rot-out 189.36 APE67-dihe-in -50.54, -27.99 -55.95, -51.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.458 APE9-dist-in 4.135 None None None XRAY 2.8 0.195 0.222 A 298 291 6 0 0 3 [[4, 286]] 1.0 2i40 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2I40C P24941 1 296 298.0 BLZ:401 Type1 Inactive DFGin 6.5 15.684 BLAminus -135.33, 178.43 51.55, 77.51 -89.62, 25.76 284.58, 71.55 -62.03, -32.72 in-in in 8.887 Saltbr-in 2.947 HRD-in -75.92, -56.81 84.43, -19.08 in-in-out SNCiio in-out ActLoopNT-in 2.786 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -117.69, -26.4 APE9-dihe-na -42.35, 127.37 APE8-dihe-in -54.04, 136.23 APE8-rot-in 299.61 APE67-dihe-in -58.47, -31.19 -61.46, -43.46 APE12-dist-out 14.259 APE11-dist-in 12.034 APE10-dist-out 8.018 APE9-dist-in 4.557 None None None XRAY 2.8 0.195 0.222 C 298 296 0 0 0 0 [[4, 286]] 1.0 2i40 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UUEA P24941 1 296 298.0 MTZ:1297 Type1 Inactive DFGin 6.668 15.552 BLAminus -136.51, -179.65 55.04, 76.1 -99.46, 27.06 276.81, 66.03 -71.99, -20.9 in-in in 8.424 Saltbr-in 2.99 HRD-in -83.38, -47.65 80.14, -16.01 in-in-out SNCiio in-out ActLoopNT-in 2.883 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -101.45, 44.37 APE9-dihe-na -136.17, 15.14 APE8-dihe-out 83.13, 148.34 APE8-rot-out 226.35 APE67-dihe-in -65.4, -22.8 -105.43, -48.8 APE12-dist-out 14.683 APE11-dist-in 11.62 APE10-dist-out 9.277 APE9-dist-in 5.446 None None None XRAY 2.06 0.197 0.244 A 298 296 0 0 0 0 [[4, 286]] 1.0 2uue Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UUEC P24941 1 297 298.0 MTZ:1298 Type1 Inactive DFGin 6.549 15.634 BLAminus -139.6, 174.69 63.14, 72.39 -91.13, 24.55 277.59, 65.12 -71.23, -27.72 in-in in 8.585 Saltbr-in 2.887 HRD-in -84.99, -51.24 81.34, -14.94 in-in-out SNCiio in-out ActLoopNT-in 2.846 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioi APE10-dihe-na -103.79, 100.15 APE9-dihe-na -148.09, 37.68 APE8-dihe-out 71.12, 132.14 APE8-rot-in 268.33 APE67-dihe-in -63.15, -29.14 -103.73, -38.08 APE12-dist-out 14.954 APE11-dist-in 10.215 APE10-dist-out 10.31 APE9-dist-in 5.642 None None None XRAY 2.06 0.197 0.244 C 298 297 0 0 0 0 [[4, 286]] 1.0 2uue Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UZBA P24941 1 296 298.0 C75:1297 Type1 Inactive DFGin 6.471 15.057 BLAminus -129.19, -178.51 56.65, 88.46 -107.29, 15.28 270.35, 76.74 -60.46, -29.47 in-in in 8.535 Saltbr-in 2.518 HRD-in -73.89, -54.05 70.29, 11.12 in-in-out SNCiio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iioi APE10-dihe-na -148.51, 138.56 APE9-dihe-na 70.2, 129.64 APE8-dihe-out -36.9, -63.1 APE8-rot-in 288.05 APE67-dihe-out -70.04, -6.32 176.95, -44.48 APE12-dist-in 13.304 APE11-dist-in 10.692 APE10-dist-out 8.012 APE9-dist-in 3.283 None TPO160 TPO160 XRAY 2.7 0.204 0.265 A 298 296 0 0 0 0 [[4, 286]] 1.0 2uzb Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UZBC P24941 1 296 298.0 C75:1297 Type1 Inactive DFGin 6.522 14.908 BLAminus -140.34, 177.92 49.12, 95.7 -109.59, 12.68 278.13, 73.33 -52.09, -28.0 in-in in 8.549 Saltbr-in 2.283 HRD-in -73.05, -55.02 77.4, -9.35 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -142.42, 147.08 APE9-dihe-na 62.72, 130.96 APE8-dihe-in -51.48, 137.46 APE8-rot-in 296.88 APE67-dihe-in -63.1, -14.88 -43.44, -51.26 APE12-dist-in 13.444 APE11-dist-in 10.901 APE10-dist-out 8.158 APE9-dist-in 3.288 None TPO160 TPO160 XRAY 2.7 0.204 0.265 C 298 296 0 0 0 0 [[4, 286]] 1.0 2uzb Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WEVA P24941 1 296 298.0 CK7:1297 Type1 Inactive DFGin 6.544 15.198 BLAminus -137.41, 168.51 60.01, 89.74 -102.99, 17.97 279.57, 71.74 -57.11, -35.26 in-in in 8.511 Saltbr-in 2.846 HRD-in -69.59, -48.84 79.69, -15.41 in-in-out SNCiio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -105.15, 11.47 APE9-dihe-na -89.16, -44.89 APE8-dihe-out 143.37, 137.63 APE8-rot-out 228.7 APE67-dihe-in -61.17, -29.84 -80.46, -51.97 APE12-dist-out 14.099 APE11-dist-in 11.434 APE10-dist-out 8.181 APE9-dist-in 5.084 None None None XRAY 2.3 0.19 0.243 A 298 296 0 0 0 0 [[4, 286]] 1.0 2wev Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WEVC P24941 1 297 298.0 CK7:1298 Type1 Inactive DFGin 6.55 15.195 BLAminus -133.81, 172.14 61.33, 84.34 -99.44, 26.27 283.39, 69.9 -63.87, -37.78 in-in in 8.143 Saltbr-in 2.433 HRD-in -72.76, -51.33 81.44, -12.38 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -100.11, 130.34 APE9-dihe-na -149.09, 144.26 APE8-dihe-in -80.58, 128.5 APE8-rot-out 70.59 APE67-dihe-in -55.73, -32.73 -97.58, -7.58 APE12-dist-out 14.848 APE11-dist-in 9.707 APE10-dist-out 12.361 APE9-dist-out 9.181 None None None XRAY 2.3 0.19 0.243 C 298 297 0 0 0 0 [[4, 286]] 1.0 2wev Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2X1NA P24941 1 296 298.0 X1N:1297 Type1 Inactive DFGin 6.424 15.518 BLAminus -128.87, 173.75 57.37, 81.12 -96.89, 24.14 281.65, 61.56 -56.06, -34.95 in-in in 8.616 Saltbr-in 2.789 HRD-in -83.76, -48.79 78.25, -11.35 in-in-out SNCiio in-out ActLoopNT-in 2.777 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioi APE10-dihe-na -113.97, 28.15 APE9-dihe-na -117.45, 36.28 APE8-dihe-out 70.98, 159.25 APE8-rot-out 222.34 APE67-dihe-in -54.58, -36.43 -112.0, -52.59 APE12-dist-out 14.527 APE11-dist-in 11.495 APE10-dist-out 8.41 APE9-dist-in 5.364 None None None XRAY 2.75 0.201 0.255 A 298 296 0 0 0 0 [[4, 286]] 1.0 2x1n Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2X1NC P24941 1 297 298.0 X1N:1298 Type1 Inactive DFGin 6.519 15.581 BLAminus -140.69, 175.53 56.15, 80.34 -98.54, 27.35 281.18, 64.02 -63.04, -37.34 in-in in 8.557 Saltbr-in 2.659 HRD-in -84.17, -48.0 72.08, -11.97 in-in-out SNCiio in-out ActLoopNT-in 2.842 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioi APE10-dihe-na 171.44, 21.19 APE9-dihe-na -101.12, -165.53 APE8-dihe-out -79.77, -47.71 APE8-rot-out 65.2 APE67-dihe-out 41.1, -61.77 83.85, -152.78 APE12-dist-in 13.959 APE11-dist-in 11.515 APE10-dist-out 8.051 APE9-dist-in 5.584 None None None XRAY 2.75 0.201 0.255 C 298 297 0 0 0 0 [[4, 286]] 1.0 2x1n Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3EJ1A P24941 1 298 298.0 5BP:299 Type1 Inactive DFGin 6.529 15.014 BLAminus -120.39, -170.6 34.57, 102.84 -117.66, 33.2 277.9, 72.92 -74.44, -26.93 in-in in 8.423 Saltbr-in 3.014 HRD-in -80.36, -45.99 78.08, -25.82 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -76.39, -8.58 APE9-dihe-na -57.46, 149.87 APE8-dihe-in -50.94, 143.15 APE8-rot-out 178.4 APE67-dihe-in -71.26, -28.12 -76.42, -41.79 APE12-dist-in 13.499 APE11-dist-in 11.112 APE10-dist-out 8.04 APE9-dist-in 5.228 None None None XRAY 3.22 0.221 0.259 A 298 295 3 0 0 0 [[4, 286]] 1.0 3ej1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3EJ1C P24941 1 297 298.0 5BP:299 Type1 Inactive DFGin 6.369 15.042 BLAminus -144.37, -176.79 46.4, 77.05 -94.51, 19.83 282.26, 67.49 -58.35, -21.4 in-in in 8.458 Saltbr-in 3.139 HRD-in -76.98, -52.36 75.48, -9.6 in-in-out SNCiio in-out ActLoopNT-in 2.936 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioi APE10-dihe-na -84.78, -32.93 APE9-dihe-na -40.13, 131.59 APE8-dihe-in -49.27, 137.46 APE8-rot-out 170.58 APE67-dihe-in -60.52, -32.57 -69.36, -45.07 APE12-dist-out 14.918 APE11-dist-in 11.897 APE10-dist-out 8.109 APE9-dist-in 4.553 None None None XRAY 3.22 0.221 0.259 C 298 294 3 0 0 0 [[4, 286]] 1.0 3ej1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3EOCC P24941 1 296 298.0 T2A:501 Type1 Inactive DFGin 6.611 15.546 BLAminus -134.65, 174.05 57.27, 76.83 -94.67, 37.28 281.99, 69.27 -70.56, -37.12 in-in in 8.56 Saltbr-in 2.849 HRD-in -83.74, -52.0 74.56, -5.56 in-in-out SNCiio in-out ActLoopNT-in 2.773 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -115.04, 10.56 APE9-dihe-na -74.14, 148.71 APE8-dihe-in -60.81, 135.44 APE8-rot-in 317.1 APE67-dihe-in -54.07, -37.93 -65.67, -45.23 APE12-dist-out 14.196 APE11-dist-in 11.582 APE10-dist-in 7.941 APE9-dist-in 4.519 None None None XRAY 3.2 0.216 0.238 C 298 293 3 0 0 0 [[4, 286]] 1.0 3eoc Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3TIYA P24941 2 298 298.0 TIY:311 Type1 Inactive DFGin 8.87 14.878 BLAminus -126.04, 167.5 54.82, 63.4 -71.45, -6.97 283.55, 59.96 76.63, -119.91 out-out out 15.568 Saltbr-out 15.476 HRD-in -82.34, -63.91 78.23, -16.74 out-out-out SNCooo out-out ActLoopNT-out 5.998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -95.26, 112.87 APE9-dihe-na -58.02, 134.56 APE8-dihe-in -84.54, 123.93 APE8-rot-out 191.63 APE67-dihe-in -58.87, -29.31 -96.47, -4.21 APE12-dist-out 22.087 APE11-dist-out 17.696 APE10-dist-out 20.214 APE9-dist-out 10.946 None None None XRAY 1.84 0.184 0.224 A 298 293 4 0 0 0 [[4, 286]] 1.0 3tiy Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FX3A P24941 1 298 298.0 60K:301 Type1 Inactive DFGin 6.197 15.103 BLAminus -126.13, 178.6 49.1, 93.46 -105.8, 30.24 276.32, 71.06 -61.87, -44.99 in-in in 8.424 Saltbr-in 2.924 HRD-in -80.6, -54.87 72.29, 6.25 in-in-out SNCiio in-out ActLoopNT-in 2.879 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -130.98, 158.93 APE9-dihe-na -62.78, 151.96 APE8-dihe-in -53.23, 142.13 APE8-rot-out 179.6 APE67-dihe-in -43.78, -29.12 -33.97, -54.96 APE12-dist-in 10.58 APE11-dist-out 5.7 APE10-dist-out 8.894 APE9-dist-in 3.726 None None None XRAY 2.75 0.192 0.24 A 298 298 0 0 0 0 [[4, 286]] 1.0 4fx3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FX3C P24941 1 298 298.0 60K:301 Type1 Inactive DFGin 6.172 15.026 BLAminus -134.21, -178.78 44.13, 89.74 -104.79, 28.66 280.48, 70.83 -64.33, -46.69 in-in in 8.486 Saltbr-in 3.094 HRD-in -72.23, -48.72 69.82, -6.08 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -143.68, -175.34 APE9-dihe-na -66.47, 158.06 APE8-dihe-in -51.29, 145.45 APE8-rot-in 314.05 APE67-dihe-in -46.63, -39.05 -40.33, -50.3 APE12-dist-in 11.252 APE11-dist-out 6.439 APE10-dist-out 8.445 APE9-dist-in 3.665 None None None XRAY 2.75 0.192 0.24 C 298 298 0 0 0 0 [[4, 286]] 1.0 4fx3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8CURA P24941 1 296 298.0 OW6:301 Type1 Inactive DFGin 9.773 15.723 BLAminus -137.32, 165.63 62.71, 70.1 -84.84, 10.34 282.1, 70.32 55.44, 35.34 out-out out 16.699 Saltbr-out 16.127 HRD-in -88.63, -55.17 83.16, -14.53 out-out-out SNCooo out-out ActLoopNT-out 10.118 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 130.72 APE9-dihe-na -139.45, 145.22 APE8-dihe-in -77.77, 135.94 APE8-rot-out 177.91 APE67-dihe-in -60.81, -26.31 -95.02, 0.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.855 APE9-dist-out 10.893 None None None XRAY 2.2 0.201 0.267 A 298 274 22 0 0 11 [[4, 286]] 1.0 8cur Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8H6PA P24941 1 297 298.0 WZU:60301 Type1 Inactive DFGin 6.832 15.812 BLAminus -138.9, 169.91 56.25, 91.6 -100.72, 19.84 277.25, 72.88 -67.38, -28.56 in-in in 9.187 Saltbr-in 2.866 HRD-in -76.72, -60.89 80.19, -5.93 in-in-out SNCiio in-out ActLoopNT-in 2.772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.82, 146.29 APE9-dihe-na 73.34, 130.66 APE8-dihe-in -67.97, 146.16 APE8-rot-out 97.01 APE67-dihe-in -66.71, -23.48 -48.91, -47.0 APE12-dist-in 12.739 APE11-dist-in 9.978 APE10-dist-in 7.097 APE9-dist-in 3.143 None TPO160 TPO160 XRAY 2.44 0.222 0.292 A 298 297 0 0 0 0 [[4, 286]] 1.0 8h6p Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3DDQC P24941 1 297 298.0 RRC:60299 Type1 Inactive DFGin 6.683 15.237 BLAminus -135.03, 174.73 51.22, 81.22 -92.28, 22.06 280.24, 71.12 -61.17, -31.8 in-in in 8.802 Saltbr-in 2.629 HRD-in -78.79, -55.27 70.81, 11.54 in-in-out SNCiio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.5, 150.72 APE9-dihe-na 67.57, 123.07 APE8-dihe-in -58.23, 146.27 APE8-rot-out 184.04 APE67-dihe-in -63.49, -21.74 -43.48, -49.11 APE12-dist-in 12.765 APE11-dist-in 9.988 APE10-dist-in 6.863 APE9-dist-in 3.244 None TPO160 TPO160 XRAY 1.8 0.196 0.229 C 299 266 31 0 0 0 [[4, 286]] 1.0 3ddq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3DOGA P24941 1 298 298.0 NNN:60299 Type1 Inactive DFGin 6.622 15.124 BLAminus -123.83, 171.95 56.41, 94.47 -105.53, 13.92 276.45, 71.26 -61.4, -24.91 in-in in 8.343 Saltbr-in 2.572 HRD-in -74.01, -59.72 75.02, 13.59 in-in-out SNCiio in-out ActLoopNT-in 2.977 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -158.74, 129.37 APE9-dihe-na 67.46, 135.39 APE8-dihe-in -55.08, 134.55 APE8-rot-in 285.3 APE67-dihe-in -61.78, -16.0 -48.46, -43.14 APE12-dist-in 12.737 APE11-dist-in 9.742 APE10-dist-out 8.219 APE9-dist-in 3.151 None TPO160 TPO160 XRAY 2.7 0.197 0.248 A 299 297 1 0 0 0 [[4, 286]] 1.0 3dog Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3DOGC P24941 1 297 298.0 NNN:60299 Type1 Inactive DFGin 6.592 14.999 BLAminus -128.02, 179.32 44.45, 89.67 -97.23, 22.43 280.59, 63.22 -60.28, -33.83 in-in in 8.292 Saltbr-in 2.674 HRD-in -85.15, -49.99 70.0, 6.47 in-in-out SNCiio in-out ActLoopNT-in 2.917 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.97, -49.47 APE9-dihe-na -120.71, 146.21 APE8-dihe-in -55.12, 140.65 APE8-rot-out 83.77 APE67-dihe-in -60.72, -21.94 -37.84, -55.18 APE12-dist-in 12.779 APE11-dist-in 10.306 APE10-dist-in 7.459 APE9-dist-in 3.326 None TPO160 TPO160 XRAY 2.7 0.197 0.248 C 299 267 30 0 0 0 [[4, 286]] 1.0 3dog Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6JGMA P24941 1 298 298.0 AQG:900 Type1 Inactive DFGin 9.549 15.591 BLAminus -111.97, 138.12 84.08, 77.16 -91.54, 40.25 302.73, 39.97 -125.42, 999.0 out-out out 14.929 Saltbr-out 13.825 HRD-in -91.45, -57.13 77.4, -6.2 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 113.03 APE9-dihe-na -69.43, 143.39 APE8-dihe-in -89.14, 138.92 APE8-rot-in 298.11 APE67-dihe-in -55.83, -28.78 -108.79, -2.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.684 None None None XRAY 2.3 0.218 0.29 A 299 279 19 0 0 15 [[4, 286]] 1.0 6jgm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8B54A P24941 1 294 298.0 P2V:301 Type1 Inactive DFGin 6.514 15.247 BLAminus -128.12, 170.62 59.1, 85.13 -100.08, 22.73 286.24, 67.7 -63.02, -30.99 in-in in 8.487 Saltbr-in 2.815 HRD-in -82.86, -54.52 68.83, 22.28 in-in-out SNCiio in-out ActLoopNT-in 3.055 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -99.69, 158.44 APE9-dihe-na 80.04, 135.87 APE8-dihe-in -60.84, 136.8 APE8-rot-out 36.15 APE67-dihe-in -51.66, -27.71 -44.78, -57.24 APE12-dist-in 13.431 APE11-dist-in 12.01 APE10-dist-in 7.248 APE9-dist-in 3.365 None TPO160 TPO160 XRAY 2.6 0.234 0.287 A 299 292 2 0 0 0 [[4, 286]] 1.0 8b54 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4NJ3A P24941 1 298 298.0 2KD:60301 Type1 Inactive DFGin 9.341 15.594 BLAminus -130.79, 172.52 45.12, 81.35 -88.92, 3.27 284.6, 64.16 63.2, 34.26 out-out out 16.126 Saltbr-out 15.981 HRD-in -77.06, -53.47 83.75, -19.23 out-out-out SNCooo out-out ActLoopNT-out 10.694 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -66.4, 122.78 APE9-dihe-na -80.52, 121.26 APE8-dihe-in -75.92, 125.78 APE8-rot-in 291.48 APE67-dihe-in -50.09, -30.36 -105.53, -5.27 APE12-dist-none 999.0 APE11-dist-out 16.997 APE10-dist-out 20.365 APE9-dist-out 10.989 None None CSD177 XRAY 1.848 0.184 0.231 A 299 281 17 0 0 11 [[4, 286]] 1.0 4nj3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOSA P24941 1 297 298.0 1RO:60301 Type1 Inactive DFGin 6.679 14.917 BLAminus -141.96, 173.39 61.75, 76.99 -94.88, 23.86 287.29, 67.82 -62.13, -29.58 in-in in 8.579 Saltbr-in 2.677 HRD-in -71.72, -54.24 68.99, 15.84 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -51.01, 139.09 APE9-dihe-na 90.64, 134.44 APE8-dihe-in -63.39, 144.28 APE8-rot-out 31.42 APE67-dihe-in -59.13, -27.23 -51.22, -47.22 APE12-dist-in 13.101 APE11-dist-in 9.197 APE10-dist-in 7.565 APE9-dist-in 3.512 None TPO160 TPO160 XRAY 2.57 0.232 0.274 A 300 294 3 0 0 0 [[4, 286]] 1.0 4eos Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOSC P24941 1 296 298.0 1RO:60301 Type1 Inactive DFGin 6.674 15.293 BLAminus -142.14, 172.73 60.66, 72.59 -88.34, 30.63 286.6, 69.5 -72.66, -28.9 in-in in 8.394 Saltbr-in 2.646 HRD-in -72.54, -50.67 68.34, 9.35 in-in-out SNCiio in-out ActLoopNT-in 2.911 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.28, 156.88 APE9-dihe-na 66.24, 127.49 APE8-dihe-in -57.72, 139.89 APE8-rot-out 169.26 APE67-dihe-in -54.97, -19.05 -46.71, -53.73 APE12-dist-in 13.153 APE11-dist-in 10.99 APE10-dist-in 7.365 APE9-dist-in 3.239 None TPO160 TPO160 XRAY 2.57 0.232 0.274 C 300 296 0 0 0 0 [[4, 286]] 1.0 4eos Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H1QA P24941 1 296 298.0 2A6:61298 Type1 Inactive DFGin 6.512 14.862 BLAminus -132.06, 176.21 56.25, 86.82 -91.89, 16.14 280.93, 75.89 -52.78, -45.0 in-out in 8.598 Saltbr-out 4.199 HRD-in -78.2, -44.47 62.96, 33.71 out-in-in SNCoii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.52, 142.46 APE9-dihe-na 75.73, 142.33 APE8-dihe-in -61.63, 140.37 APE8-rot-in 280.51 APE67-dihe-in -59.24, -24.16 -43.09, -55.2 APE12-dist-in 13.017 APE11-dist-in 10.083 APE10-dist-in 7.927 APE9-dist-in 3.398 None TPO160 TPO160 XRAY 2.5 0.238 0.332 A 303 296 0 0 0 0 [[4, 286]] 1.0 1h1q Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7MKXA P24941 1 296 298.0 ZGY:60301 Type1 Inactive DFGin 6.578 14.754 BLAminus -140.81, 169.83 55.63, 72.68 -84.48, 27.67 300.0, 1.18 -58.86, -37.01 in-out in 8.233 Saltbr-out 4.248 HRD-in -77.94, -57.51 70.73, 8.99 out-in-in SNCoii in-in ActLoopNT-in 3.013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.98, 89.93 APE9-dihe-na -179.85, 149.23 APE8-dihe-in -56.28, 134.25 APE8-rot-in 299.51 APE67-dihe-in -61.78, -21.13 -52.49, -48.37 APE12-dist-in 13.006 APE11-dist-in 10.709 APE10-dist-in 6.616 APE9-dist-in 3.694 None TPO160 TPO160 XRAY 3.08 0.248 0.289 A 303 296 0 0 0 0 [[4, 286]] 1.0 7mkx Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QTWA P24941 1 298 298.0 X3A:451 Type1 Inactive DFGin 7.73 15.217 BLAminus -131.36, 171.83 40.9, 66.71 -61.52, 26.46 278.45, 73.23 55.91, 3.95 out-out out 15.732 Saltbr-out 13.313 HRD-in -80.23, -54.25 80.72, -17.72 out-out-out SNCooo out-out ActLoopNT-out 8.125 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -93.97, 97.99 APE9-dihe-na -56.3, 134.54 APE8-dihe-in -84.65, 125.77 APE8-rot-in 290.71 APE67-dihe-in -53.75, -28.5 -99.0, -5.65 APE12-dist-out 20.622 APE11-dist-out 16.387 APE10-dist-out 19.661 APE9-dist-out 11.03 None None None XRAY 1.85 0.214 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qtw Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QU0A P24941 1 298 298.0 X40:454 Type1 Inactive DFGin 8.208 15.216 BLAminus -137.77, 171.11 51.19, 48.86 -48.06, 22.21 276.83, 64.07 70.99, -93.38 out-out out 15.404 Saltbr-out 13.133 HRD-in -77.95, -57.59 82.19, -12.98 out-out-out SNCooo out-out ActLoopNT-out 6.995 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -80.6, 105.78 APE9-dihe-na -55.28, 133.76 APE8-dihe-in -87.35, 122.14 APE8-rot-in 286.9 APE67-dihe-in -53.38, -29.6 -99.0, -5.34 APE12-dist-out 20.003 APE11-dist-out 16.977 APE10-dist-out 19.489 APE9-dist-out 11.05 None None None XRAY 1.95 0.2 0.251 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qu0 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R9DA P24941 1 298 298.0 X6B:590 Type1 Inactive DFGin 8.079 15.003 BLAminus -121.15, 171.34 50.75, 77.19 -81.47, 59.23 282.0, 70.7 42.22, -95.41 out-out out 14.344 Saltbr-out 13.877 HRD-in -79.82, -53.09 77.88, -18.23 out-out-out SNCooo out-out ActLoopNT-out 8.068 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -62.43, 100.13 APE9-dihe-na -65.78, 136.3 APE8-dihe-in -79.92, 127.08 APE8-rot-in 316.73 APE67-dihe-in -56.64, -26.83 -105.63, 0.44 APE12-dist-out 20.579 APE11-dist-out 17.238 APE10-dist-out 19.702 APE9-dist-out 11.175 None None None XRAY 1.95 0.208 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r9d Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R9OA P24941 1 298 298.0 Z71:401 Type1 Inactive DFGin 7.709 14.949 BLAminus -124.92, 169.14 49.25, 74.17 -72.51, 33.52 279.64, 74.41 59.11, -27.51 out-out out 14.984 Saltbr-out 12.552 HRD-in -81.51, -55.77 82.39, -19.38 out-out-out SNCooo out-out ActLoopNT-out 7.653 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 146.46 APE9-dihe-na -63.83, 134.08 APE8-dihe-in -88.2, 125.53 APE8-rot-in 303.25 APE67-dihe-in -55.2, -29.65 -103.97, 0.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.638 APE9-dist-out 11.19 None None None XRAY 1.9 0.209 0.246 A 306 282 16 0 0 8 [[4, 286]] 1.0 3r9o Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RZBA P24941 1 298 298.0 02Z:458 Type1 Inactive DFGin 7.849 15.011 BLAminus -134.02, 177.25 47.06, 50.38 -50.09, -22.29 279.93, 72.46 71.6, 17.08 out-out out 14.525 Saltbr-out 10.733 HRD-in -86.05, -51.61 79.43, -21.53 out-out-out SNCooo out-out ActLoopNT-out 7.992 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 174.25 APE9-dihe-na -55.19, 127.5 APE8-dihe-in -87.87, 126.45 APE8-rot-in 311.53 APE67-dihe-in -53.26, -30.3 -104.83, -2.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.58 APE9-dist-out 11.151 None None None XRAY 1.9 0.205 0.245 A 306 282 16 0 0 8 [[4, 286]] 1.0 3rzb Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1VYWA P24941 1 298 298.0 292:62300 Type1 Inactive DFGin 6.31 15.448 BLAminus -142.09, -179.46 62.07, 68.01 -93.04, 26.77 283.3, 67.04 -60.71, -37.42 in-in in 8.774 Saltbr-in 2.688 HRD-in -75.98, -56.94 73.1, 1.68 in-in-out SNCiio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -141.65, 150.84 APE9-dihe-na -49.59, 152.46 APE8-dihe-in -61.68, 143.78 APE8-rot-out 189.06 APE67-dihe-in -52.32, -27.96 -37.01, -54.78 APE12-dist-in 10.865 APE11-dist-out 6.148 APE10-dist-out 9.397 APE9-dist-in 3.864 None None None XRAY 2.3 0.229 0.258 A 309 298 0 0 0 0 [[4, 286]] 1.0 1vyw Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2BPMA P24941 1 298 298.0 529:61299 Type1 Inactive DFGin 6.239 15.11 BLAminus -142.26, 176.11 58.91, 81.01 -97.86, 30.66 284.19, 66.4 -66.03, -17.23 in-in in 8.702 Saltbr-in 3.207 HRD-in -74.89, -55.37 69.86, 9.24 in-in-out SNCiio in-out ActLoopNT-in 2.876 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -145.78, 149.41 APE9-dihe-na -60.82, 153.33 APE8-dihe-in -56.05, 145.85 APE8-rot-out 190.64 APE67-dihe-in -49.62, -26.99 -36.83, -56.93 APE12-dist-in 10.954 APE11-dist-out 6.128 APE10-dist-out 9.188 APE9-dist-in 3.97 None None None XRAY 2.4 0.229 0.271 A 309 298 0 0 0 0 [[4, 286]] 1.0 2bpm Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C4GA P24941 1 297 298.0 514:60306 Type1 Inactive DFGin 6.374 15.686 BLAminus -138.0, -179.21 56.78, 81.52 -100.19, 24.26 280.76, 69.34 -56.0, -30.57 in-in in 9.074 Saltbr-in 3.53 HRD-in -75.28, -49.4 66.04, 8.2 in-in-out SNCiio in-out ActLoopNT-in 2.765 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -135.18, 160.53 APE9-dihe-na -59.36, 149.34 APE8-dihe-in -58.64, 140.5 APE8-rot-out 179.78 APE67-dihe-in -54.42, -23.62 -30.84, -55.83 APE12-dist-in 10.723 APE11-dist-out 5.978 APE10-dist-out 9.285 APE9-dist-in 3.726 None None None XRAY 2.7 0.233 0.25 A 309 297 0 0 0 0 [[4, 286]] 1.0 2c4g Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WIHA P24941 1 298 298.0 P48:61299 Type1 Inactive DFGin 6.323 15.153 BLAminus -141.48, 174.43 62.06, 78.82 -96.32, 29.99 282.61, 69.45 -63.78, -17.45 in-in in 8.899 Saltbr-in 2.735 HRD-in -77.3, -59.72 79.63, -0.51 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -126.75, 155.26 APE9-dihe-na -53.97, 153.09 APE8-dihe-in -55.51, 151.53 APE8-rot-out 190.5 APE67-dihe-in -57.21, -28.57 -52.08, -46.97 APE12-dist-in 10.856 APE11-dist-out 6.1 APE10-dist-out 9.308 APE9-dist-in 3.946 None None None XRAY 2.5 0.215 0.25 A 309 298 0 0 0 0 [[4, 286]] 1.0 2wih Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WIPA P24941 1 298 298.0 P49:61299 Type1 Inactive DFGin 6.213 14.953 BLAminus -142.46, 178.98 56.18, 81.9 -99.03, 23.63 283.85, 66.21 -56.05, -33.18 in-in in 8.634 Saltbr-in 2.853 HRD-in -72.23, -57.81 81.71, -8.44 in-in-out SNCiio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -130.17, 149.32 APE9-dihe-na -61.56, 147.19 APE8-dihe-in -53.43, 148.35 APE8-rot-out 180.82 APE67-dihe-in -63.04, -20.64 -55.16, -41.78 APE12-dist-in 10.952 APE11-dist-out 6.172 APE10-dist-out 9.445 APE9-dist-in 3.754 None None None XRAY 2.8 0.221 0.258 A 309 293 5 0 0 0 [[4, 286]] 1.0 2wip Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WIPC P24941 1 296 298.0 P49:61297 Type1 Inactive DFGin 6.239 14.98 BLAminus -141.29, -179.48 53.82, 83.38 -100.32, 23.88 283.87, 67.06 -55.38, -33.16 in-in in 8.625 Saltbr-in 2.839 HRD-in -72.71, -56.85 82.33, -8.67 in-in-out SNCiio in-out ActLoopNT-in 2.807 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.79, -53.2 APE9-dihe-na -69.06, 145.9 APE8-dihe-in -52.62, 147.98 APE8-rot-out 180.17 APE67-dihe-in -61.14, -22.34 -56.62, -40.71 APE12-dist-in 13.16 APE11-dist-in 12.121 APE10-dist-in 6.699 APE9-dist-in 3.739 None None None XRAY 2.8 0.221 0.258 C 309 291 5 0 0 0 [[4, 286]] 1.0 2wip Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WPAA P24941 1 298 298.0 889:61301 Type1 Inactive DFGin 6.403 15.335 BLAminus -135.21, 176.53 58.02, 88.7 -107.68, 28.03 282.69, 64.08 -64.19, -28.37 in-in in 8.816 Saltbr-in 3.082 HRD-in -79.47, -55.07 78.51, -3.12 in-in-out SNCiio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -130.67, 154.23 APE9-dihe-na -48.84, 141.61 APE8-dihe-in -52.21, 154.2 APE8-rot-out 181.43 APE67-dihe-in -63.89, -20.76 -52.89, -45.76 APE12-dist-in 10.982 APE11-dist-out 6.302 APE10-dist-out 9.354 APE9-dist-in 3.669 None None None XRAY 2.51 0.223 0.261 A 309 298 0 0 0 0 [[4, 286]] 1.0 2wpa Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WXVA P24941 1 298 298.0 WXV:61299 Type1 Inactive DFGin 6.349 15.217 BLAminus -142.15, 179.34 61.25, 75.54 -95.71, 30.2 288.43, 61.13 -64.45, -20.88 in-in in 9.154 Saltbr-in 2.788 HRD-in -80.45, -59.16 79.81, 3.89 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -129.11, 152.72 APE9-dihe-na -47.52, 148.72 APE8-dihe-in -58.45, 150.0 APE8-rot-out 188.9 APE67-dihe-in -58.49, -20.25 -50.64, -47.18 APE12-dist-in 11.14 APE11-dist-out 6.199 APE10-dist-out 9.4 APE9-dist-in 3.978 None None None XRAY 2.6 0.211 0.243 A 309 298 0 0 0 0 [[4, 286]] 1.0 2wxv Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2WXVC P24941 1 298 298.0 WXV:61299 Type1 Inactive DFGin 6.436 15.754 BLAminus -137.28, 178.13 57.28, 77.18 -93.24, 25.48 280.18, 69.88 -57.67, -33.57 in-in in 9.05 Saltbr-in 2.751 HRD-in -85.48, -52.71 75.37, -2.61 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, -70.34 APE9-dihe-na -55.13, 128.55 APE8-dihe-in -50.61, 142.19 APE8-rot-out 174.77 APE67-dihe-in -59.06, -25.31 -62.32, -39.8 APE12-dist-in 13.841 APE11-dist-in 12.241 APE10-dist-in 7.071 APE9-dist-in 3.703 None None None XRAY 2.6 0.211 0.243 C 309 298 0 0 0 0 [[4, 286]] 1.0 2wxv Homo sapiens CMGC_CDK2_HUMAN CMGC 7.3e-90 307.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOKA P24941 1 297 298.0 4SP:60301 Type1 Inactive DFGin 6.758 14.917 BLAminus -134.3, -179.84 46.41, 76.35 -85.3, 26.99 282.69, 74.66 -63.13, -40.98 in-in in 8.405 Saltbr-in 2.751 HRD-in -74.27, -58.79 75.22, 5.66 in-in-out SNCiio in-out ActLoopNT-in 3.154 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -48.8, 159.15 APE9-dihe-na 69.58, 123.71 APE8-dihe-in -65.07, 144.66 APE8-rot-out 74.13 APE67-dihe-in -57.65, -17.47 -43.62, -55.86 APE12-dist-in 12.685 APE11-dist-in 9.044 APE10-dist-in 6.584 APE9-dist-in 3.22 H84S,Q85M,K89D TPO160 TPO160 XRAY 2.57 0.225 0.259 A 300 293 4 0 0 0 [[4, 286]] 1.0 4eok Homo sapiens CMGC_CDK2_HUMAN CMGC 2.1e-89 306.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOKC P24941 1 297 298.0 4SP:60301 Type1 Inactive DFGin 6.679 14.976 BLAminus -133.72, 176.62 49.75, 77.33 -90.85, 27.24 282.19, 75.0 -59.18, -42.5 in-in in 8.555 Saltbr-in 2.678 HRD-in -87.05, -50.89 65.34, 17.25 in-in-out SNCiio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.36, 150.06 APE9-dihe-na 67.77, 135.16 APE8-dihe-in -66.26, 146.78 APE8-rot-out 54.84 APE67-dihe-in -67.63, -15.19 -39.34, -49.74 APE12-dist-in 12.965 APE11-dist-in 10.176 APE10-dist-in 7.022 APE9-dist-in 3.364 H84S,Q85M,K89D TPO160 TPO160 XRAY 2.57 0.225 0.259 C 300 297 0 0 0 0 [[4, 286]] 1.0 4eok Homo sapiens CMGC_CDK2_HUMAN CMGC 2.1e-89 306.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOLA P24941 1 297 298.0 1RO:60301 Type1 Inactive DFGin 6.607 15.129 BLAminus -135.34, 178.76 52.69, 78.64 -93.77, 24.68 279.7, 73.17 -67.66, -22.78 in-in in 8.475 Saltbr-in 2.603 HRD-in -77.83, -51.08 67.91, 10.46 in-in-out SNCiio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -47.84, 152.66 APE9-dihe-na 70.88, 128.41 APE8-dihe-in -63.25, 140.1 APE8-rot-out 109.89 APE67-dihe-in -57.3, -27.39 -42.52, -53.62 APE12-dist-in 12.934 APE11-dist-in 9.113 APE10-dist-in 7.001 APE9-dist-in 3.265 H84S,Q85M,K89D TPO160 TPO160 XRAY 2.4 0.22 0.246 A 300 294 3 0 0 0 [[4, 286]] 1.0 4eol Homo sapiens CMGC_CDK2_HUMAN CMGC 2.1e-89 306.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EOLC P24941 1 297 298.0 1RO:60301 Type1 Inactive DFGin 6.451 14.894 BLAminus -145.3, 177.27 50.92, 76.98 -90.22, 25.77 287.42, 70.08 -65.23, -28.63 in-in in 8.481 Saltbr-in 2.726 HRD-in -76.44, -57.62 72.84, 10.6 in-in-out SNCiio in-out ActLoopNT-in 3.053 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.35, 153.03 APE9-dihe-na 66.62, 132.64 APE8-dihe-in -69.73, 142.81 APE8-rot-out 77.64 APE67-dihe-in -60.23, -13.71 -39.45, -54.36 APE12-dist-in 12.793 APE11-dist-in 10.134 APE10-dist-in 6.914 APE9-dist-in 3.157 H84S,Q85M,K89D TPO160 TPO160 XRAY 2.4 0.22 0.246 C 300 297 0 0 0 0 [[4, 286]] 1.0 4eol Homo sapiens CMGC_CDK2_HUMAN CMGC 2.1e-89 306.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3F5XA P24941 1 298 298.0 EZV:300 Type1.5_Back Inactive DFGin 6.264 15.144 BLAminus -134.58, -179.48 51.7, 79.18 -97.87, 23.07 283.96, 70.29 -60.84, -38.34 in-in in 8.688 Saltbr-in 2.691 HRD-in -75.24, -51.59 71.39, 2.05 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -175.83, 160.35 APE9-dihe-na 3.68, 102.57 APE8-dihe-in -38.96, 146.61 APE8-rot-out 193.19 APE67-dihe-in -61.73, -24.77 -51.83, -42.77 APE12-dist-in 11.503 APE11-dist-in 8.374 APE10-dist-out 8.433 APE9-dist-in 4.006 None None None XRAY 2.4 0.266 0.283 A 298 297 1 0 0 0 [[4, 286]] 1.0 3f5x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3F5XC P24941 1 298 298.0 EZV:300 Type1.5_Back Inactive DFGin 6.407 15.46 BLAminus -135.18, 179.33 51.86, 80.85 -99.79, 26.02 279.88, 72.23 -63.21, -36.5 in-in in 8.807 Saltbr-in 3.066 HRD-in -71.85, -53.32 74.6, -0.68 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 133.52, -152.44 APE9-dihe-na 7.07, 96.3 APE8-dihe-in -36.48, 145.34 APE8-rot-out 171.35 APE67-dihe-in -62.68, -23.78 -54.39, -38.57 APE12-dist-in 11.492 APE11-dist-in 8.799 APE10-dist-in 6.679 APE9-dist-in 3.934 None None None XRAY 2.4 0.266 0.283 C 298 298 0 0 0 0 [[4, 286]] 1.0 3f5x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3PXFA P24941 1 298 298.0 2AN:60304,2AN:60305 Allosteric,Type3 Inactive DFGin 6.804 14.953 BLBminus -156.99, 169.67 57.7, 49.35 -58.76, 147.9 286.72, 73.73 -84.97, 33.17 out-out out 17.118 Saltbr-out 15.963 HRD-in -83.12, -53.61 79.99, -16.11 out-out-out SNCooo out-out ActLoopNT-out 10.28 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -144.89, 166.86 APE9-dihe-na -179.55, 11.71 APE8-dihe-out -60.35, -25.0 APE8-rot-in 308.45 APE67-dihe-in -57.16, -27.46 -60.95, -33.0 APE12-dist-out 17.995 APE11-dist-out 18.625 APE10-dist-out 15.567 APE9-dist-out 11.402 None None None XRAY 1.8 0.198 0.229 A 306 298 0 0 0 0 [[4, 286]] 1.0 3pxf Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3PXZA P24941 1 298 298.0 2AN:60299,2AN:60300,JWS:60301 Allosteric,Type3,Type1 Inactive DFGin 6.837 15.033 BLBminus -155.67, 166.51 60.28, 50.57 -60.22, 145.8 284.9, 75.18 -84.49, 38.36 out-out out 17.125 Saltbr-out 15.789 HRD-in -85.51, -53.14 79.88, -15.95 out-out-out SNCooo out-out ActLoopNT-out 10.493 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -158.71, 154.36 APE9-dihe-na -170.99, 21.17 APE8-dihe-out -68.66, -23.41 APE8-rot-in 291.0 APE67-dihe-in -58.73, -27.74 -57.67, -32.22 APE12-dist-out 18.609 APE11-dist-out 18.664 APE10-dist-out 15.39 APE9-dist-out 11.201 None None None XRAY 1.7 0.214 0.256 A 306 298 0 0 0 0 [[4, 286]] 1.0 3pxz Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6YL6A P24941 1 298 298.0 No_ligand No_ligand Inactive DFGin 10.863 18.115 BLBminus -103.63, 148.99 75.14, 24.25 -51.89, 141.19 255.4, 92.77 84.95, -19.74 out-out out 15.757 Saltbr-out 17.82 HRD-in -85.94, -59.1 81.31, -16.09 out-out-out SNCooo out-out ActLoopNT-out 5.714 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.56, 129.93 APE9-dihe-na -73.61, 128.6 APE8-dihe-in -68.6, 141.32 APE8-rot-out 185.54 APE67-dihe-in -63.71, -24.64 -98.13, -3.21 APE12-dist-out 19.604 APE11-dist-out 17.493 APE10-dist-out 18.694 APE9-dist-out 10.68 F80C,C177A None None XRAY 1.7 0.181 999.0 A 303 298 0 0 0 0 [[4, 286]] 1.0 6yl6 Homo sapiens CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7UXIA P24941 2 298 298.0 No_ligand No_ligand Inactive DFGin 7.325 16.323 BLBminus -139.56, 169.86 72.82, 31.27 -62.6, 132.48 291.85, 80.25 77.82, 0.77 out-out out 15.264 Saltbr-out 14.935 HRD-in -80.34, -52.7 82.21, -18.9 out-out-out SNCooo out-out ActLoopNT-out 10.275 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nioo APE10-dihe-na -66.01, -43.19 APE9-dihe-na -72.45, -32.29 APE8-dihe-out -82.35, -8.83 APE8-rot-in 318.55 APE67-dihe-in -63.65, -20.19 -64.17, -39.1 APE12-dist-none 999.0 APE11-dist-in 12.42 APE10-dist-out 15.427 APE9-dist-out 11.047 None None None XRAY 2.07 0.213 0.264 A 299 280 17 0 0 10 [[4, 286]] 1.0 7uxi Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5OO3A P24941 2 294 298.0 9ZB:301 Type1 Inactive DFGin 10.277 17.84 BLBminus -105.88, 161.12 68.35, 21.75 -51.13, 140.89 255.15, 98.44 84.24, -24.81 out-out out 15.845 Saltbr-out 17.272 HRD-in -86.8, -57.25 80.19, -12.06 out-out-out SNCooo out-out ActLoopNT-out 6.034 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.26, 128.65 APE9-dihe-na -76.42, 126.3 APE8-dihe-in -64.14, 140.44 APE8-rot-out 189.48 APE67-dihe-in -65.38, -23.78 -96.62, -3.82 APE12-dist-out 18.961 APE11-dist-out 16.837 APE10-dist-out 18.193 APE9-dist-out 10.629 F80C,C177A None None XRAY 1.73 0.187 0.249 A 303 286 7 0 0 0 [[4, 286]] 1.0 5oo3 Homo sapiens CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6YL1A P24941 1 298 298.0 OWN:60301 Type1 Inactive DFGin 7.95 15.24 BLBminus -143.36, 162.7 66.75, 47.2 -58.43, 136.45 285.0, 64.94 -84.51, 131.85 out-out out 14.75 Saltbr-out 11.873 HRD-in -82.26, -54.45 85.26, -17.45 out-out-out SNCooo out-out ActLoopNT-out 9.23 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -124.6, 139.89 APE9-dihe-na -62.39, 127.0 APE8-dihe-in -79.51, 132.47 APE8-rot-in 318.07 APE67-dihe-in -63.6, -24.03 -104.61, -3.32 APE12-dist-none 999.0 APE11-dist-out 18.366 APE10-dist-out 19.344 APE9-dist-out 10.63 F80C,C177A None None XRAY 1.66 0.221 0.269 A 303 282 16 0 0 8 [[4, 286]] 1.0 6yl1 Homo sapiens CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6YLKA P24941 1 298 298.0 OY2:60301 Type1 Inactive DFGin 7.952 15.498 BLBminus -142.19, 161.67 68.26, 47.12 -55.19, 133.15 279.48, 76.41 -85.9, 135.49 out-out out 14.633 Saltbr-out 12.008 HRD-in -80.3, -49.52 80.8, -21.78 out-out-out SNCooo out-out ActLoopNT-out 9.917 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -64.14, -26.57 APE9-dihe-na -84.23, 3.13 APE8-dihe-out -54.63, -49.39 APE8-rot-in 298.42 APE67-dihe-in -64.89, -21.17 -94.45, -4.99 APE12-dist-out 19.148 APE11-dist-out 18.717 APE10-dist-out 22.913 APE9-dist-out 12.38 F80C,C177A None None XRAY 1.65 0.218 0.265 A 303 290 8 0 0 0 [[4, 286]] 1.0 6ylk Homo sapiens CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1DM2A P24941 1 298 298.0 HMD:400 Type1 Inactive DFGin 8.083 15.174 BLBminus -135.33, 165.14 60.62, 59.67 -72.31, 120.69 284.69, 66.98 -63.1, 154.86 out-out out 14.661 Saltbr-out 13.059 HRD-in -85.27, -51.86 82.75, -26.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.99 APE8-dihe-in -79.63, 132.91 APE8-rot-in 302.05 APE67-dihe-in -50.64, -29.01 -107.85, 0.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.85 None None None XRAY 2.1 0.228 0.267 A 298 274 24 0 0 15 [[4, 286]] 1.0 1dm2 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1G5SA P24941 1 298 298.0 I17:400 Type1 Inactive DFGin 8.115 15.085 BLBminus -133.53, 166.37 48.49, 70.76 -65.03, -169.31 288.65, 66.47 -113.64, -144.89 out-out out 14.437 Saltbr-out 15.731 HRD-in -81.81, -51.14 79.05, -24.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 69.48 APE9-dihe-na -71.54, 141.91 APE8-dihe-in -80.46, 140.28 APE8-rot-in 302.83 APE67-dihe-in -56.57, -23.66 -123.68, -3.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.631 APE9-dist-out 11.556 None None None XRAY 2.61 0.201 0.242 A 298 275 23 0 0 14 [[4, 286]] 1.0 1g5s Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1P2AA P24941 1 298 298.0 5BN:301 Type1 Inactive DFGin 8.291 15.384 BLBminus -135.83, 154.98 66.07, 45.16 -52.68, 139.63 284.12, 63.94 -91.55, 168.0 out-out out 14.635 Saltbr-out 13.838 HRD-in -81.24, -45.32 77.95, -29.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -17.11 APE8-dihe-in -87.95, 131.35 APE8-rot-in 296.72 APE67-dihe-in -44.63, -35.11 -105.7, -4.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.348 None None None XRAY 2.5 0.206 0.28 A 298 271 27 0 0 14 [[4, 286]] 1.0 1p2a Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PF8A P24941 1 298 298.0 SU9:500 Type1 Inactive DFGin 8.475 15.741 BLBminus -129.7, 146.62 62.68, 69.99 -68.65, 116.11 284.82, 69.79 -69.63, 152.74 out-out out 14.943 Saltbr-out 11.878 HRD-in -101.08, -46.86 78.76, -29.91 out-out-out SNCooo out-out ActLoopNT-out 9.501 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -74.3, 116.67 APE9-dihe-na -125.72, -92.3 APE8-dihe-in -84.61, 116.88 APE8-rot-out 174.62 APE67-dihe-in -66.44, -33.29 -122.64, 33.07 APE12-dist-out 18.72 APE11-dist-in 13.677 APE10-dist-out 15.284 APE9-dist-out 12.387 None None None XRAY 2.51 0.208 0.306 A 298 298 0 0 0 0 [[4, 286]] 1.0 1pf8 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2B52A P24941 1 298 298.0 D42:299 Type1 Inactive DFGin 8.893 15.268 BLBminus -141.64, 169.72 53.46, 46.38 -53.81, 159.81 285.46, 64.51 -81.56, 93.65 out-out out 15.004 Saltbr-out 14.984 HRD-in -82.92, -50.4 80.09, -21.1 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -159.99, 74.27 APE9-dihe-na -52.16, 130.95 APE8-dihe-in -78.6, 151.41 APE8-rot-out 59.38 APE67-dihe-in -45.68, -32.57 -107.57, -0.59 APE12-dist-out 19.475 APE11-dist-out 18.176 APE10-dist-out 20.224 APE9-dist-out 10.755 None None None XRAY 1.88 0.219 0.275 A 298 283 15 0 0 11 [[4, 286]] 1.0 2b52 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2B55A P24941 1 298 298.0 D31:299 Type1 Inactive DFGin 8.587 15.146 BLBminus -143.99, 166.23 55.34, 53.27 -57.84, 157.15 282.56, 63.76 -67.56, 999.0 out-out out 14.909 Saltbr-out 15.496 HRD-in -82.43, -49.58 79.3, -23.81 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 107.35 APE9-dihe-na -74.82, 135.43 APE8-dihe-in -72.48, 144.46 APE8-rot-out 176.71 APE67-dihe-in -48.29, -30.13 -111.52, -5.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.846 None None None XRAY 1.85 0.213 0.256 A 298 276 22 0 0 15 [[4, 286]] 1.0 2b55 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2BHEA P24941 1 298 298.0 BRY:1299 Type1 Inactive DFGin 8.566 15.479 BLBminus -119.95, 159.77 54.95, 56.83 -56.89, 138.54 291.8, 58.17 -95.42, 153.43 out-out out 15.015 Saltbr-out 11.977 HRD-in -80.13, -51.98 82.04, -20.94 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -24.27 APE8-dihe-in -71.12, 121.18 APE8-rot-in 287.89 APE67-dihe-in -66.24, -23.49 -99.49, 11.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.13 None None None XRAY 1.9 0.246 0.322 A 298 274 24 0 0 15 [[4, 286]] 1.0 2bhe Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2BHHA P24941 1 298 298.0 RYU:1299 Type1 Inactive DFGin 8.374 16.731 BLBminus -90.01, 171.16 32.35, 80.04 -64.56, 114.63 263.52, 80.58 -60.68, 123.83 out-out out 15.485 Saltbr-out 15.878 HRD-in -83.09, -51.19 79.21, -29.81 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -3.46 APE8-dihe-in -109.93, 126.87 APE8-rot-in 293.41 APE67-dihe-in -44.53, -42.0 -104.51, -7.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.984 None None None XRAY 2.6 0.244 0.325 A 298 274 24 0 0 15 [[4, 286]] 1.0 2bhh Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2BTSA P24941 1 298 298.0 U32:1299 Type1 Inactive DFGin 8.571 15.954 BLBminus -131.25, 144.03 57.41, 68.71 -62.53, 135.6 279.58, 62.82 -80.98, 150.36 out-out out 15.624 Saltbr-out 14.997 HRD-in -78.23, -53.97 79.57, -25.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 156.64 APE8-dihe-in -86.98, 135.56 APE8-rot-in 291.23 APE67-dihe-in -60.1, -28.56 -107.23, -11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.197 None None None XRAY 1.99 0.216 0.261 A 298 274 24 0 0 15 [[4, 286]] 1.0 2bts Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C5YA P24941 1 297 298.0 MTW:1298 Type1 Inactive DFGin 9.4 16.657 BLBminus -119.33, 163.14 63.9, 25.09 -37.93, 176.97 281.77, 102.48 32.41, -5.42 out-out out 15.829 Saltbr-out 18.808 HRD-in -83.1, -53.31 80.34, -18.94 out-out-out SNCooo out-out ActLoopNT-out 5.984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.09, 126.86 APE9-dihe-na -82.0, 122.2 APE8-dihe-in -67.98, 138.89 APE8-rot-out 178.11 APE67-dihe-in -60.87, -23.53 -96.51, 2.32 APE12-dist-out 19.365 APE11-dist-out 17.172 APE10-dist-out 18.356 APE9-dist-out 10.546 None None None XRAY 2.25 0.172 0.295 A 298 290 7 0 0 0 [[4, 286]] 1.0 2c5y Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2FVDA P24941 1 298 298.0 LIA:299 Type1 Inactive DFGin 8.27 15.847 BLBminus -129.08, 161.73 54.66, 55.26 -58.18, 137.13 271.85, 72.54 -100.76, 151.69 out-out out 14.71 Saltbr-out 11.728 HRD-in -85.22, -52.32 84.78, -19.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.5, -29.7 APE9-dihe-na -80.34, -3.97 APE8-dihe-out -41.1, -43.49 APE8-rot-in 299.83 APE67-dihe-in -55.14, -24.36 -106.63, -5.17 APE12-dist-out 21.16 APE11-dist-out 18.528 APE10-dist-out 23.032 APE9-dist-out 12.501 None None None XRAY 1.85 0.207 0.235 A 298 284 14 0 0 2 [[4, 286]] 1.0 2fvd Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2J9MA P24941 1 298 298.0 PY8:299 Type1 Inactive DFGin 8.03 15.527 BLBminus -117.85, 155.78 63.5, 58.0 -58.66, 135.53 288.36, 61.8 -84.13, 156.08 out-out out 14.938 Saltbr-out 13.62 HRD-in -68.66, -54.24 85.35, -33.48 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 25.87 APE8-dihe-in -127.82, 119.52 APE8-rot-in 290.66 APE67-dihe-in -54.74, -26.86 -98.36, 2.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.774 None None None XRAY 2.5 0.219 0.294 A 298 275 23 0 0 15 [[4, 286]] 1.0 2j9m Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTNA P24941 1 298 298.0 LZ7:1299 Type1 Inactive DFGin 8.225 15.48 BLBminus -130.59, 169.64 59.02, 44.37 -44.98, 149.46 274.53, 71.88 -46.74, 999.0 out-out out 15.013 Saltbr-out 10.346 HRD-in -71.77, -52.62 82.25, -20.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 15.58 APE8-dihe-in -73.85, 143.51 APE8-rot-in 326.04 APE67-dihe-in -55.91, -32.82 -112.63, -13.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.04 None None None XRAY 2.2 0.207 0.251 A 298 274 24 0 0 16 [[4, 286]] 1.0 2vtn Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTQA P24941 1 298 298.0 LZA:1299 Type1 Inactive DFGin 8.044 14.046 BLBminus -129.75, 168.07 58.97, 49.95 -59.94, 124.1 301.31, 117.69 -69.88, 999.0 out-out out 15.12 Saltbr-out 15.345 HRD-in -77.76, -54.42 82.1, -19.72 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 147.28 APE9-dihe-na -86.24, 119.48 APE8-dihe-in -63.08, 130.94 APE8-rot-in 312.05 APE67-dihe-in -59.55, -25.84 -105.72, -2.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.668 None None None XRAY 1.9 0.202 0.244 A 298 274 24 0 0 15 [[4, 286]] 1.0 2vtq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTTA P24941 1 298 298.0 LZD:1299 Type1 Inactive DFGin 8.256 15.788 BLBminus -133.83, 163.13 58.79, 49.54 -50.81, 118.96 266.7, 80.52 -61.31, 131.96 out-out out 14.895 Saltbr-out 15.463 HRD-in -78.88, -51.32 81.52, -27.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 23.3 APE8-dihe-out -41.16, -42.29 APE8-rot-in 294.63 APE67-dihe-in -54.78, -27.63 -116.87, -16.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.407 None None None XRAY 1.68 0.201 0.227 A 298 272 26 0 0 15 [[4, 286]] 1.0 2vtt Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VU3A P24941 1 298 298.0 LZE:1299 Type1 Inactive DFGin 8.322 15.708 BLBminus -139.52, 167.07 59.03, 42.09 -48.49, 136.01 273.65, 80.97 -89.56, 999.0 out-out out 14.825 Saltbr-out 14.507 HRD-in -75.5, -58.82 93.01, -22.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -57.28, -32.4 APE9-dihe-na -76.07, 0.26 APE8-dihe-out -51.02, -50.13 APE8-rot-in 294.74 APE67-dihe-in -56.87, -26.43 -97.91, -6.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.782 None None None XRAY 1.85 0.205 0.246 A 298 285 13 0 0 4 [[4, 286]] 1.0 2vu3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3TI1A P24941 1 298 298.0 B49:299 Type1 Inactive DFGin 7.489 14.948 BLBminus -138.54, 165.85 55.25, 50.84 -54.7, 138.08 282.79, 63.1 -95.42, 15.79 out-out out 16.039 Saltbr-out 14.61 HRD-in -73.91, -54.49 74.09, -22.19 out-out-out SNCooo out-out ActLoopNT-out 7.753 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -103.63, 110.78 APE9-dihe-na -67.36, 128.32 APE8-dihe-in -75.16, 126.28 APE8-rot-in 271.07 APE67-dihe-in -58.11, -32.93 -95.87, -2.85 APE12-dist-out 22.302 APE11-dist-out 17.662 APE10-dist-out 19.612 APE9-dist-out 10.928 None None None XRAY 1.99 0.205 0.262 A 298 294 4 0 0 0 [[4, 286]] 1.0 3ti1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3TIZA P24941 2 298 298.0 3TI:299 Type1 Inactive DFGin 10.973 17.532 BLBminus -121.88, 153.78 71.63, 29.3 -62.4, 138.79 252.83, 105.63 73.11, -2.13 out-out out 15.481 Saltbr-out 14.687 HRD-in -81.14, -61.85 79.6, -22.98 out-out-out SNCooo out-out ActLoopNT-out 5.806 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.61, 119.72 APE9-dihe-na -69.51, 139.31 APE8-dihe-in -83.35, 120.56 APE8-rot-in 316.47 APE67-dihe-in -57.22, -29.02 -92.83, -8.7 APE12-dist-out 21.169 APE11-dist-out 17.662 APE10-dist-out 19.63 APE9-dist-out 11.076 None None None XRAY 2.02 0.193 0.243 A 298 293 4 0 0 0 [[4, 286]] 1.0 3tiz Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3UNJA P24941 1 298 298.0 0BX:299 Type1 Inactive DFGin 9.438 16.055 BLBminus -126.16, 158.39 62.91, 62.36 -77.38, -172.61 283.66, 79.73 54.11, -145.34 out-out out 16.135 Saltbr-out 15.089 HRD-in -80.95, -60.65 73.54, -8.03 out-out-out SNCooo out-out ActLoopNT-out 6.541 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.71, 161.6 APE9-dihe-na -82.53, 132.15 APE8-dihe-in -80.46, 120.61 APE8-rot-in 287.27 APE67-dihe-in -57.53, -30.48 -95.93, -10.88 APE12-dist-out 19.108 APE11-dist-out 15.322 APE10-dist-out 17.398 APE9-dist-out 10.259 None None None XRAY 1.9 0.199 0.261 A 298 294 4 0 0 0 [[4, 286]] 1.0 3unj Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3UNKA P24941 1 298 298.0 0BY:299 Type1 Inactive DFGin 10.533 16.223 BLBminus -114.51, 154.53 72.02, 37.13 -66.62, 159.38 284.73, 91.48 68.14, 3.66 out-out out 15.727 Saltbr-out 15.237 HRD-in -82.35, -66.03 72.22, -7.05 out-out-out SNCooo out-out ActLoopNT-out 6.064 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -93.01, 107.46 APE9-dihe-na -73.24, 145.2 APE8-dihe-in -85.61, 121.8 APE8-rot-in 315.14 APE67-dihe-in -60.87, -28.03 -91.32, -9.56 APE12-dist-out 20.477 APE11-dist-out 15.907 APE10-dist-out 19.29 APE9-dist-out 10.867 None None None XRAY 2.1 0.18 0.234 A 298 295 3 0 0 0 [[4, 286]] 1.0 3unk Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5ANGA P24941 2 298 298.0 WY3:1299 Type1 Inactive DFGin 8.868 15.157 BLBminus -130.67, 171.05 57.07, 51.35 -60.9, 146.23 281.41, 63.94 -94.86, 128.98 out-out out 15.002 Saltbr-out 16.558 HRD-in -78.59, -53.71 84.86, -19.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 134.85 APE9-dihe-na -71.3, 134.15 APE8-dihe-in -89.85, 123.32 APE8-rot-out 177.6 APE67-dihe-in -58.83, -24.55 -100.56, -2.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.521 APE9-dist-out 11.042 None None None XRAY 1.9 0.199 0.236 A 298 268 29 0 0 14 [[4, 286]] 1.0 5ang Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7M2FA P24941 1 298 298.0 YOS:901 Type1 Inactive DFGin 8.238 15.928 BLBminus -124.95, 157.78 58.01, 58.37 -57.83, 131.16 273.81, 74.67 -79.75, 999.0 out-out out 14.915 Saltbr-out 14.506 HRD-in -84.12, -50.42 80.86, -23.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -59.96, -32.85 APE9-dihe-na -80.07, -7.31 APE8-dihe-out -42.65, -49.66 APE8-rot-in 298.23 APE67-dihe-in -56.75, -24.69 -99.35, -4.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.45 None None None XRAY 1.632 0.213 0.258 A 298 281 17 0 0 7 [[4, 286]] 1.0 7m2f Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9D0UA P24941 1 298 298.0 A1A1H:301 Type1 Inactive DFGin 8.525 15.649 BLBminus -132.55, 155.33 56.61, 71.46 -74.59, 136.49 281.17, 65.2 -85.62, 123.9 out-out out 15.265 Saltbr-out 16.659 HRD-in -93.27, -34.94 68.53, -43.24 out-out-out SNCooo out-out ActLoopNT-out 9.727 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -37.05 APE9-dihe-na -84.27, -7.27 APE8-dihe-out -69.63, -34.14 APE8-rot-in 261.42 APE67-dihe-in -61.77, -19.59 -63.83, -33.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.764 APE9-dist-out 11.069 None None None XRAY 2.6 0.212 0.26 A 298 289 9 0 0 4 [[4, 286]] 1.0 9d0u Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8ERDA P24941 1 298 298.0 WQ6:60301 Type1 Inactive DFGin 8.582 16.25 BLBminus -121.63, 153.55 64.02, 56.7 -53.48, 130.5 279.82, 76.74 -85.1, 132.91 out-out out 15.219 Saltbr-out 12.847 HRD-in -82.72, -53.82 84.17, -16.58 out-out-out SNCooo out-out ActLoopNT-out 8.31 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.0, 121.72 APE9-dihe-na -70.09, 126.97 APE8-dihe-in -72.45, 132.03 APE8-rot-in 300.88 APE67-dihe-in -65.57, -22.99 -101.28, -0.94 APE12-dist-out 22.29 APE11-dist-out 17.27 APE10-dist-out 19.93 APE9-dist-out 10.69 None None None XRAY 1.33 0.2 0.23 A 299 289 9 0 0 0 [[4, 286]] 1.0 8erd Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6INLA P24941 1 298 298.0 AJR:900 Type1 Inactive DFGin 8.882 15.786 BLBminus -114.41, 156.22 62.32, 59.76 -55.94, 135.44 282.1, 69.83 -73.88, 999.0 out-out out 14.95 Saltbr-out 12.111 HRD-in -81.05, -54.19 74.12, -14.31 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 131.87 APE9-dihe-na -61.97, 121.14 APE8-dihe-in -76.94, 131.87 APE8-rot-in 298.25 APE67-dihe-in -66.19, -22.53 -100.18, -0.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.711 None None None XRAY 1.75 0.198 0.25 A 299 272 26 0 0 15 [[4, 286]] 1.0 6inl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3NA P24941 1 298 298.0 SCZ:60501 Type1 Inactive DFGin 8.416 15.479 BLBminus -121.51, 161.73 41.2, 69.04 -57.76, 139.27 285.76, 53.18 -53.0, -108.82 out-out out 14.723 Saltbr-out 13.652 HRD-in -85.77, -49.05 76.79, -22.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 999.0 APE9-dihe-na -82.82, 151.99 APE8-dihe-in -77.41, 140.97 APE8-rot-in 291.31 APE67-dihe-in -51.95, -31.61 -104.46, -5.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.536 APE9-dist-out 10.59 None None CSD177 XRAY 1.63 0.194 0.235 A 299 278 20 0 0 13 [[4, 286]] 1.0 2r3n Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VV9A P24941 1 298 298.0 IM9:61300 Type1 Inactive DFGin 8.218 15.51 BLBminus -132.35, 168.28 58.62, 53.48 -56.5, 120.83 271.74, 69.98 -71.45, 67.58 out-out out 14.812 Saltbr-out 14.168 HRD-in -81.14, -53.22 85.21, -25.04 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 141.64 APE9-dihe-na -77.31, 132.24 APE8-dihe-in -82.9, 131.82 APE8-rot-in 288.88 APE67-dihe-in -62.1, -27.84 -105.84, -2.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.349 APE9-dist-out 10.742 None None None XRAY 1.9 0.191 0.228 A 299 279 19 0 0 13 [[4, 286]] 1.0 2vv9 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2W17A P24941 1 298 298.0 I19:61300 Type1 Inactive DFGin 8.167 15.288 BLBminus -141.56, 164.03 56.33, 54.71 -56.05, 126.33 275.29, 58.06 -57.84, 112.26 out-out out 14.51 Saltbr-out 13.797 HRD-in -79.07, -54.07 82.47, -13.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 129.89 APE9-dihe-na -78.62, 144.12 APE8-dihe-in -83.44, 130.58 APE8-rot-in 331.95 APE67-dihe-in -64.21, -24.47 -97.58, -1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.515 APE9-dist-out 10.76 None None None XRAY 2.15 0.244 0.3 A 299 278 20 0 0 13 [[4, 286]] 1.0 2w17 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3SW7A P24941 1 298 298.0 19K:60299 Type1 Inactive DFGin 8.833 15.538 BLBminus -125.05, 148.22 57.95, 72.53 -63.08, 133.83 291.84, 84.89 -87.94, 155.03 out-out out 15.136 Saltbr-out 12.624 HRD-in -82.34, -55.27 82.2, -11.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 127.1 APE9-dihe-na -65.13, 123.16 APE8-dihe-in -82.38, 129.61 APE8-rot-in 302.03 APE67-dihe-in -53.76, -28.96 -102.46, -4.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.76 APE9-dist-out 10.988 None None None XRAY 1.8 0.184 0.215 A 299 278 20 0 0 13 [[4, 286]] 1.0 3sw7 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BZDA P24941 1 298 298.0 D6I:1300 Type1 Inactive DFGin 8.765 15.198 BLBminus -126.42, 161.93 70.87, 40.79 -59.87, 104.24 285.85, 66.11 -63.46, 149.33 out-none out 15.002 Saltbr-none 999.0 HRD-in -78.39, -56.59 87.31, -16.52 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 126.06 APE9-dihe-na -67.74, 131.97 APE8-dihe-in -81.87, 126.69 APE8-rot-in 299.36 APE67-dihe-in -62.2, -26.77 -100.75, -2.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.163 APE9-dist-out 11.001 None None None XRAY 1.83 0.175 0.204 A 299 277 21 0 0 14 [[4, 286]] 1.0 4bzd Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKOA P24941 1 298 298.0 20K:60301 Type1 Inactive DFGin 8.666 15.426 BLBminus -125.43, 149.85 58.65, 75.86 -66.7, 135.67 292.47, 87.98 -92.67, 155.02 out-out out 15.142 Saltbr-out 13.061 HRD-in -80.88, -55.11 82.09, -14.53 out-out-out SNCooo out-out ActLoopNT-out 9.541 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -126.3, 148.91 APE9-dihe-na -72.88, 122.25 APE8-dihe-in -81.91, 129.97 APE8-rot-out 181.44 APE67-dihe-in -54.84, -27.69 -101.92, -3.56 APE12-dist-out 25.51 APE11-dist-out 19.876 APE10-dist-out 20.825 APE9-dist-out 11.033 None None None XRAY 1.55 0.177 0.199 A 299 291 7 0 0 0 [[4, 286]] 1.0 4fko Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3EZVA P24941 1 298 298.0 EZV:300 Type1 Inactive DFGin 8.262 15.435 BLBminus -136.58, 166.86 64.1, 47.24 -55.25, 135.65 278.78, 70.77 -82.58, 149.84 out-out out 14.71 Saltbr-out 13.139 HRD-in -78.98, -52.27 84.47, -21.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 136.2 APE9-dihe-na -72.4, 130.59 APE8-dihe-in -82.3, 130.13 APE8-rot-out 173.31 APE67-dihe-in -55.91, -25.19 -101.39, -9.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.912 APE9-dist-out 10.695 None None None XRAY 1.99 0.228 0.244 A 300 277 21 0 0 14 [[4, 286]] 1.0 3ezv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7RA5A P24941 1 296 298.0 3I3:60301 Type1 Inactive DFGin 8.26 16.262 BLBminus -130.98, 161.74 65.66, 56.4 -59.51, 113.29 274.73, 77.08 -76.57, 141.92 out-out out 15.133 Saltbr-out 13.959 HRD-in -75.17, -54.32 86.45, -14.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 126.63 APE9-dihe-na -74.84, 124.49 APE8-dihe-in -68.75, 135.9 APE8-rot-out 188.92 APE67-dihe-in -62.25, -25.5 -106.26, -3.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.983 APE9-dist-out 10.556 None None None XRAY 1.67 0.23 0.274 A 300 276 20 0 0 13 [[4, 286]] 1.0 7ra5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8YNGA P24941 1 298 298.0 A1D6S:60301 Type1 Inactive DFGin 7.83 15.57 BLBminus -126.5, 150.43 58.8, 62.69 -59.01, 143.24 282.79, 63.5 -92.6, 140.82 out-out out 14.465 Saltbr-out 11.549 HRD-in -77.58, -51.0 83.01, -21.74 out-out-out SNCooo out-out ActLoopNT-out 9.507 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -63.23, -29.54 APE9-dihe-na -79.02, 0.75 APE8-dihe-out -57.42, -40.04 APE8-rot-in 302.71 APE67-dihe-in -62.69, -22.41 -100.87, -8.87 APE12-dist-out 21.014 APE11-dist-out 18.439 APE10-dist-out 22.877 APE9-dist-out 12.131 None None None XRAY 1.82 0.194 0.235 A 301 292 6 0 0 0 [[4, 286]] 1.0 8yng Homo sapiens CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8YPWA P24941 1 298 298.0 A1D6Z:60301 Type1 Inactive DFGin 7.624 15.038 BLBminus -134.22, 155.58 54.17, 61.51 -58.95, 141.29 285.18, 62.75 -89.34, 141.87 out-out out 14.406 Saltbr-out 11.717 HRD-in -83.47, -48.65 82.57, -20.49 out-out-out SNCooo out-out ActLoopNT-out 9.753 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -58.36, -28.82 APE9-dihe-na -67.99, -23.82 APE8-dihe-out -66.86, -23.37 APE8-rot-out 61.9 APE67-dihe-in -61.36, -25.9 -59.94, -33.92 APE12-dist-out 19.254 APE11-dist-out 15.844 APE10-dist-out 20.371 APE9-dist-out 11.817 None None None XRAY 1.8 0.184 0.22 A 303 293 5 0 0 0 [[4, 286]] 1.0 8ypw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8YQEA P24941 1 298 298.0 A1D60:60301 Type1 Inactive DFGin 7.673 15.085 BLBminus -126.43, 154.87 50.87, 65.06 -60.99, 138.76 283.84, 66.6 -84.16, 138.89 out-out out 14.371 Saltbr-out 11.208 HRD-in -82.99, -45.76 76.34, -20.67 out-out-out SNCooo out-out ActLoopNT-out 9.386 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -5.99 APE9-dihe-na 38.28, 49.91 APE8-dihe-out -78.47, 41.42 APE8-rot-out 177.29 APE67-dihe-in -62.79, -26.98 -104.83, -22.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.817 APE9-dist-out 12.488 None None None XRAY 1.94 0.202 0.242 A 303 283 15 0 0 8 [[4, 286]] 1.0 8yqe Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9JJ5A P24941 1 298 298.0 A1EB0:60301 Type1 Inactive DFGin 8.034 15.178 BLBminus -121.58, 162.45 51.13, 60.61 -56.94, 138.71 280.77, 73.38 -84.23, 142.47 out-out out 14.651 Saltbr-out 13.828 HRD-in -80.69, -53.91 85.81, -19.11 out-out-out SNCooo out-out ActLoopNT-out 9.677 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -104.38, 123.36 APE9-dihe-na -52.94, 132.38 APE8-dihe-in -83.2, 146.26 APE8-rot-out 72.21 APE67-dihe-in -60.72, -28.67 -101.72, 1.05 APE12-dist-none 999.0 APE11-dist-out 17.936 APE10-dist-out 19.197 APE9-dist-out 10.464 None None None XRAY 1.71 0.204 0.244 A 303 279 19 0 0 10 [[4, 286]] 1.0 9jj5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3PXYA P24941 1 298 298.0 JWS:299 Type1 Inactive DFGin 10.462 15.944 BLBminus -122.74, 154.77 71.04, 42.14 -72.87, 173.58 279.17, 102.98 35.69, 27.63 out-out out 15.43 Saltbr-out 16.322 HRD-in -89.87, -62.06 81.43, -12.05 out-out-out SNCooo out-out ActLoopNT-out 5.967 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -91.89, 94.51 APE9-dihe-na -54.64, 138.43 APE8-dihe-in -84.97, 123.48 APE8-rot-in 306.18 APE67-dihe-in -53.77, -24.31 -105.13, -10.69 APE12-dist-out 20.224 APE11-dist-out 16.509 APE10-dist-out 19.622 APE9-dist-out 11.08 None None None XRAY 1.8 0.211 0.242 A 306 294 4 0 0 0 [[4, 286]] 1.0 3pxy Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3PY0A P24941 1 298 298.0 SU9:301 Type1 Inactive DFGin 9.476 16.027 BLBminus -126.7, 148.83 64.28, 62.26 -73.09, -162.69 281.47, 81.1 38.41, -126.13 out-out out 15.419 Saltbr-out 13.916 HRD-in -86.2, -57.87 84.15, -15.09 out-out-out SNCooo out-out ActLoopNT-out 6.493 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.56, 92.41 APE9-dihe-na -54.93, 126.96 APE8-dihe-in -79.79, 125.98 APE8-rot-in 309.86 APE67-dihe-in -53.56, -27.28 -105.18, -7.46 APE12-dist-out 19.559 APE11-dist-out 15.444 APE10-dist-out 19.22 APE9-dist-out 11.139 None None None XRAY 1.75 0.212 0.26 A 306 294 4 0 0 0 [[4, 286]] 1.0 3py0 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QQGA P24941 1 298 298.0 X06:300 Type1 Inactive DFGin 10.744 16.408 BLBminus -121.57, 152.3 74.48, 40.06 -71.29, 157.64 270.44, 101.52 47.86, 32.19 out-out out 15.671 Saltbr-out 15.758 HRD-in -86.84, -63.36 81.9, -13.38 out-out-out SNCooo out-out ActLoopNT-out 5.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -93.88, 97.75 APE9-dihe-na -63.79, 140.02 APE8-dihe-in -81.75, 121.26 APE8-rot-in 308.13 APE67-dihe-in -51.62, -26.77 -100.5, -12.72 APE12-dist-out 20.895 APE11-dist-out 16.275 APE10-dist-out 19.502 APE9-dist-out 11.054 None None None XRAY 1.9 0.205 0.242 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qqg Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QQHA P24941 1 298 298.0 X0A:303 Type1 Inactive DFGin 10.924 16.869 BLBminus -119.07, 155.16 72.34, 39.06 -73.27, 170.06 265.1, 82.61 51.97, 3.88 out-out out 15.495 Saltbr-out 15.173 HRD-in -86.72, -61.6 84.32, -18.78 out-out-out SNCooo out-out ActLoopNT-out 5.833 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -45.62, 100.31 APE9-dihe-na -62.95, 133.96 APE8-dihe-in -80.55, 113.46 APE8-rot-in 299.01 APE67-dihe-in -52.55, -27.33 -97.79, -12.76 APE12-dist-out 20.418 APE11-dist-out 17.052 APE10-dist-out 19.573 APE9-dist-out 11.175 None None None XRAY 1.87 0.201 0.232 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qqh Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QQKA P24941 1 298 298.0 X02:497 Type1 Inactive DFGin 7.29 15.207 BLBminus -132.47, 171.25 44.74, 61.06 -59.66, 145.15 280.16, 63.99 -55.47, -65.44 out-out out 14.956 Saltbr-out 11.911 HRD-in -83.58, -52.35 81.91, -18.93 out-out-out SNCooo out-out ActLoopNT-out 7.763 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -73.11, 113.25 APE9-dihe-na -70.31, 131.43 APE8-dihe-in -81.07, 126.63 APE8-rot-in 298.78 APE67-dihe-in -52.62, -31.22 -104.13, -2.93 APE12-dist-out 21.618 APE11-dist-out 17.304 APE10-dist-out 19.891 APE9-dist-out 11.016 None None None XRAY 1.86 0.201 0.241 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qqk Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QRTA P24941 1 298 298.0 X14:535 Type1 Inactive DFGin 8.637 15.887 BLBminus -133.92, 161.18 62.84, 54.27 -62.7, 112.03 292.17, 73.36 -59.88, -51.96 out-out out 14.954 Saltbr-out 14.213 HRD-in -86.25, -54.44 79.97, -14.56 out-out-out SNCooo out-out ActLoopNT-out 7.749 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.55, 122.31 APE9-dihe-na -71.57, 125.05 APE8-dihe-in -76.9, 127.59 APE8-rot-in 303.44 APE67-dihe-in -55.97, -25.61 -103.81, -0.01 APE12-dist-out 22.81 APE11-dist-out 18.68 APE10-dist-out 20.407 APE9-dist-out 10.88 None None None XRAY 1.75 0.196 0.221 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qrt Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QRUA P24941 1 298 298.0 X19:493 Type1 Inactive DFGin 8.391 15.798 BLBminus -141.58, 159.78 61.06, 51.88 -57.35, 130.19 290.87, 74.5 -92.88, 162.73 out-out out 14.922 Saltbr-out 15.362 HRD-in -84.41, -53.63 81.51, -20.18 out-out-out SNCooo out-out ActLoopNT-out 8.401 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.02, 123.48 APE9-dihe-na -77.33, 134.65 APE8-dihe-in -76.78, 129.51 APE8-rot-out 180.19 APE67-dihe-in -52.08, -29.31 -100.18, -5.68 APE12-dist-out 20.745 APE11-dist-out 18.783 APE10-dist-out 19.707 APE9-dist-out 10.878 None None None XRAY 1.95 0.2 0.236 A 306 295 3 0 0 0 [[4, 286]] 1.0 3qru Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QTQA P24941 1 298 298.0 X35:476 Type1 Inactive DFGin 8.037 15.326 BLBminus -134.07, 169.77 50.18, 51.65 -54.92, 133.54 279.48, 69.67 -45.42, -64.6 out-out out 14.761 Saltbr-out 14.88 HRD-in -79.34, -54.03 79.9, -15.94 out-out-out SNCooo out-out ActLoopNT-out 7.832 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -70.82, 120.08 APE9-dihe-na -73.72, 128.49 APE8-dihe-in -76.92, 124.69 APE8-rot-in 293.92 APE67-dihe-in -55.38, -27.05 -99.71, -3.98 APE12-dist-out 21.47 APE11-dist-out 17.123 APE10-dist-out 19.567 APE9-dist-out 10.976 None None None XRAY 1.8 0.204 0.233 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qtq Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QTRA P24941 1 298 298.0 X36:497 Type1 Inactive DFGin 7.991 15.109 BLBminus -135.98, 168.38 49.02, 56.34 -59.01, 137.45 280.21, 69.64 -84.87, 137.4 out-out out 15.034 Saltbr-out 11.197 HRD-in -82.64, -52.75 82.7, -20.75 out-out-out SNCooo out-out ActLoopNT-out 9.782 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -168.04 APE9-dihe-na -55.73, 122.77 APE8-dihe-in -80.55, 127.37 APE8-rot-in 308.0 APE67-dihe-in -54.76, -28.18 -106.52, -1.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.208 APE9-dist-out 11.122 None None None XRAY 1.85 0.202 0.23 A 306 282 16 0 0 8 [[4, 286]] 1.0 3qtr Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QTUA P24941 1 298 298.0 X44:451 Type1 Inactive DFGin 8.415 15.762 BLBminus -124.2, 155.48 50.29, 63.32 -57.44, 137.74 282.91, 69.35 -85.49, -45.13 out-out out 15.01 Saltbr-out 15.118 HRD-in -83.99, -51.26 82.9, -20.21 out-out-out SNCooo out-out ActLoopNT-out 7.824 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.17, 135.28 APE9-dihe-na -107.7, 135.0 APE8-dihe-in -73.46, 136.05 APE8-rot-out 193.34 APE67-dihe-in -55.54, -26.46 -111.29, -1.07 APE12-dist-out 23.013 APE11-dist-out 19.624 APE10-dist-out 20.93 APE9-dist-out 11.339 None None None XRAY 1.82 0.195 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qtu Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QTXA P24941 1 298 298.0 X43:299 Type1 Inactive DFGin 7.781 15.356 BLBminus -128.82, 166.52 48.57, 62.3 -60.66, 139.86 279.19, 71.31 -50.84, -58.14 out-out out 14.801 Saltbr-out 10.905 HRD-in -79.57, -50.58 79.44, -23.57 out-out-out SNCooo out-out ActLoopNT-out 7.35 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.69, 103.13 APE9-dihe-na -75.18, 127.32 APE8-dihe-in -69.63, 125.97 APE8-rot-out 179.61 APE67-dihe-in -51.99, -31.06 -102.46, -4.03 APE12-dist-out 21.447 APE11-dist-out 18.054 APE10-dist-out 20.379 APE9-dist-out 11.066 None None None XRAY 1.95 0.2 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qtx Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QTZA P24941 1 298 298.0 X42:453 Type1 Inactive DFGin 7.768 15.278 BLBminus -133.18, 164.28 52.99, 54.75 -56.95, 134.84 279.16, 70.75 -100.74, 4.7 out-out out 15.308 Saltbr-out 15.483 HRD-in -82.14, -50.3 81.43, -21.43 out-out-out SNCooo out-out ActLoopNT-out 7.44 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -73.19, 105.13 APE9-dihe-na -65.72, 131.59 APE8-dihe-in -80.1, 127.22 APE8-rot-in 301.54 APE67-dihe-in -55.55, -28.21 -106.83, -1.58 APE12-dist-out 21.9 APE11-dist-out 17.701 APE10-dist-out 20.271 APE9-dist-out 10.957 None None None XRAY 2.0 0.202 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qtz Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QWKA P24941 1 298 298.0 X62:493 Type1 Inactive DFGin 8.713 15.674 BLBminus -127.95, 169.35 39.64, 71.88 -70.76, 133.51 290.23, 52.56 -108.77, 49.87 out-out out 15.13 Saltbr-out 16.54 HRD-in -82.55, -56.98 83.14, -20.05 out-out-out SNCooo out-out ActLoopNT-out 8.061 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -54.72, 107.28 APE9-dihe-na -65.56, 129.36 APE8-dihe-in -81.64, 121.57 APE8-rot-in 300.12 APE67-dihe-in -54.54, -27.53 -101.43, -1.1 APE12-dist-out 21.355 APE11-dist-out 17.387 APE10-dist-out 19.844 APE9-dist-out 11.007 None None None XRAY 1.85 0.207 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qwk Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QXPA P24941 1 298 298.0 X64:300 Type1 Inactive DFGin 7.908 15.512 BLBminus -135.49, 164.67 52.44, 57.4 -62.98, 142.61 277.98, 70.01 -96.41, 145.61 out-out out 14.496 Saltbr-out 12.22 HRD-in -83.86, -49.65 79.39, -21.07 out-out-out SNCooo out-out ActLoopNT-out 9.562 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -72.01, 118.12 APE9-dihe-na -71.58, 126.15 APE8-dihe-in -77.27, 123.66 APE8-rot-in 299.27 APE67-dihe-in -54.11, -26.26 -102.0, -3.09 APE12-dist-out 20.875 APE11-dist-out 18.066 APE10-dist-out 20.082 APE9-dist-out 11.139 None None None XRAY 1.75 0.214 0.254 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qxp Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R8MA P24941 1 298 298.0 Z19:486 Type1 Inactive DFGin 10.989 17.31 BLBminus -122.41, 152.36 73.15, 33.34 -69.36, 151.5 255.2, 103.68 58.11, 16.63 out-out out 15.195 Saltbr-out 15.581 HRD-in -86.0, -60.77 82.89, -16.21 out-out-out SNCooo out-out ActLoopNT-out 8.467 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -69.41, 139.9 APE9-dihe-na -51.57, 140.21 APE8-dihe-in -90.73, 123.13 APE8-rot-out 182.54 APE67-dihe-in -54.59, -28.83 -98.3, -5.65 APE12-dist-none 999.0 APE11-dist-out 18.029 APE10-dist-out 19.579 APE9-dist-out 11.074 None None None XRAY 1.8 0.204 0.239 A 306 286 12 0 0 8 [[4, 286]] 1.0 3r8m Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R8ZA P24941 1 298 298.0 Z63:440 Type1 Inactive DFGin 8.29 15.335 BLBminus -130.9, 171.61 46.81, 58.88 -55.61, 142.97 276.8, 68.48 -58.52, -18.41 out-out out 15.229 Saltbr-out 14.87 HRD-in -82.11, -54.38 81.72, -20.6 out-out-out SNCooo out-out ActLoopNT-out 6.99 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -69.62, 127.55 APE9-dihe-na -73.92, 124.12 APE8-dihe-in -77.45, 133.26 APE8-rot-in 299.5 APE67-dihe-in -56.36, -23.43 -103.04, -1.32 APE12-dist-out 21.87 APE11-dist-out 16.548 APE10-dist-out 19.318 APE9-dist-out 10.589 None None None XRAY 1.85 0.207 0.251 A 306 290 8 0 0 4 [[4, 286]] 1.0 3r8z Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RAKA P24941 1 298 298.0 03Z:497 Type1 Inactive DFGin 8.126 15.308 BLBminus -133.09, 166.12 51.72, 55.5 -59.82, 137.01 276.67, 74.6 -91.79, 143.23 out-out out 14.823 Saltbr-out 11.516 HRD-in -85.31, -52.73 80.88, -16.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 103.47 APE9-dihe-na -66.57, 133.27 APE8-dihe-in -82.83, 126.93 APE8-rot-out 182.39 APE67-dihe-in -56.12, -27.61 -102.78, -0.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.139 APE9-dist-out 11.056 None None None XRAY 1.75 0.196 0.237 A 306 277 21 0 0 13 [[4, 286]] 1.0 3rak Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RALA P24941 1 298 298.0 04Z:499 Type1 Inactive DFGin 7.833 15.191 BLBminus -135.51, 167.61 50.29, 56.61 -59.14, 143.27 279.01, 70.58 -92.11, 138.36 out-out out 14.777 Saltbr-out 11.523 HRD-in -83.6, -52.01 81.1, -18.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 102.73 APE9-dihe-na -64.16, 134.56 APE8-dihe-in -86.02, 129.75 APE8-rot-out 181.16 APE67-dihe-in -53.9, -28.19 -103.13, -1.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.027 APE9-dist-out 11.138 None None None XRAY 1.75 0.198 0.228 A 306 277 21 0 0 13 [[4, 286]] 1.0 3ral Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RJCA P24941 1 298 298.0 06Z:450 Type1 Inactive DFGin 8.085 15.399 BLBminus -135.34, 172.85 50.1, 54.57 -59.13, 124.88 277.89, 69.35 -88.35, 2.88 out-out out 15.614 Saltbr-out 15.713 HRD-in -85.11, -52.42 81.91, -21.02 out-out-out SNCooo out-out ActLoopNT-out 7.293 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.28, 114.54 APE9-dihe-na -75.17, 128.02 APE8-dihe-in -83.73, 127.96 APE8-rot-in 291.59 APE67-dihe-in -52.65, -28.29 -101.57, -4.56 APE12-dist-out 21.421 APE11-dist-out 17.54 APE10-dist-out 19.72 APE9-dist-out 10.847 None None None XRAY 1.85 0.209 0.25 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rjc Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RK9A P24941 1 298 298.0 09Z:483 Type1 Inactive DFGin 7.98 15.359 BLBminus -131.82, 170.19 48.71, 55.23 -57.8, 135.95 279.41, 67.13 -79.86, 138.97 out-out out 14.693 Saltbr-out 14.358 HRD-in -79.25, -54.85 81.34, -17.93 out-out-out SNCooo out-out ActLoopNT-out 7.96 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -56.06, 109.06 APE9-dihe-na -69.47, 134.31 APE8-dihe-in -84.22, 124.73 APE8-rot-in 298.49 APE67-dihe-in -52.39, -30.8 -101.51, -4.3 APE12-dist-out 20.403 APE11-dist-out 16.904 APE10-dist-out 19.431 APE9-dist-out 11.116 None None None XRAY 1.85 0.211 0.252 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rk9 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RMFA P24941 1 298 298.0 20Z:496 Type1 Inactive DFGin 8.377 15.276 BLBminus -129.83, 164.82 49.28, 60.4 -59.9, 137.12 279.82, 70.96 -89.46, 127.58 out-out out 15.0 Saltbr-out 10.934 HRD-in -87.34, -53.25 82.75, -18.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 103.92 APE9-dihe-na -62.36, 129.27 APE8-dihe-in -83.67, 130.42 APE8-rot-out 183.12 APE67-dihe-in -52.19, -29.09 -107.71, -1.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.253 APE9-dist-out 11.115 None None None XRAY 1.75 0.208 0.234 A 306 278 20 0 0 13 [[4, 286]] 1.0 3rmf Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RNIA P24941 1 298 298.0 21Z:424 Type1 Inactive DFGin 8.256 15.342 BLBminus -134.89, 174.06 47.03, 52.76 -58.91, 133.55 279.59, 61.87 -91.89, 141.62 out-out out 15.369 Saltbr-out 12.061 HRD-in -82.7, -52.66 79.11, -17.74 out-out-out SNCooo out-out ActLoopNT-out 10.134 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -50.0, 129.79 APE9-dihe-na -85.93, 123.93 APE8-dihe-in -74.63, 122.3 APE8-rot-in 297.2 APE67-dihe-in -54.32, -25.21 -102.82, -4.52 APE12-dist-out 20.344 APE11-dist-out 17.515 APE10-dist-out 19.529 APE9-dist-out 11.042 None None None XRAY 1.95 0.209 0.255 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rni Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RPVA P24941 1 298 298.0 26Z:495 Type1 Inactive DFGin 7.864 15.361 BLBminus -129.42, 164.67 51.9, 56.84 -59.9, 141.65 276.65, 69.79 -91.4, 141.14 out-out out 14.599 Saltbr-out 11.732 HRD-in -80.32, -52.39 82.71, -20.67 out-out-out SNCooo out-out ActLoopNT-out 7.997 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -60.18, 108.94 APE9-dihe-na -73.22, 132.87 APE8-dihe-in -79.88, 128.02 APE8-rot-out 179.23 APE67-dihe-in -54.3, -28.91 -105.55, -1.25 APE12-dist-out 20.722 APE11-dist-out 17.514 APE10-dist-out 19.939 APE9-dist-out 11.059 None None None XRAY 1.8 0.204 0.239 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rpv Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RPYA P24941 1 298 298.0 27Z:470 Type1 Inactive DFGin 8.003 15.017 BLBminus -132.06, 172.66 52.86, 48.25 -55.95, 137.26 281.19, 70.31 -87.65, 136.45 out-out out 14.644 Saltbr-out 10.284 HRD-in -81.36, -51.43 80.57, -20.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 100.77 APE9-dihe-na -61.76, 138.29 APE8-dihe-in -87.6, 129.84 APE8-rot-in 309.15 APE67-dihe-in -53.92, -30.09 -108.26, -3.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.627 APE9-dist-out 11.118 None None None XRAY 1.9 0.203 0.251 A 306 277 21 0 0 13 [[4, 286]] 1.0 3rpy Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3S1HA P24941 1 298 298.0 56Z:479 Type1 Inactive DFGin 8.181 15.258 BLBminus -130.77, 169.31 45.06, 59.36 -59.76, 144.0 279.87, 70.72 -93.94, 139.68 out-out out 14.855 Saltbr-out 11.204 HRD-in -87.93, -51.08 80.53, -18.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 99.22 APE9-dihe-na -59.88, 137.31 APE8-dihe-in -88.14, 131.16 APE8-rot-out 181.31 APE67-dihe-in -54.25, -29.26 -105.99, -0.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.339 APE9-dist-out 11.165 None None None XRAY 1.75 0.209 0.25 A 306 277 21 0 0 13 [[4, 286]] 1.0 3s1h Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3SQQA P24941 1 298 298.0 99Z:456 Type1 Inactive DFGin 7.727 15.493 BLBminus -133.88, 167.76 51.73, 56.7 -62.04, 141.7 276.47, 71.84 -97.5, 141.15 out-out out 14.434 Saltbr-out 11.744 HRD-in -82.77, -51.82 82.27, -21.93 out-out-out SNCooo out-out ActLoopNT-out 9.387 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -144.66, 112.47 APE9-dihe-na -74.52, 130.02 APE8-dihe-in -78.03, 123.84 APE8-rot-in 302.57 APE67-dihe-in -56.36, -26.87 -102.77, -1.64 APE12-dist-out 22.556 APE11-dist-out 17.588 APE10-dist-out 19.969 APE9-dist-out 11.006 None None None XRAY 1.85 0.204 0.236 A 306 288 10 0 0 6 [[4, 286]] 1.0 3sqq Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4ERWA P24941 1 298 298.0 STU:301 Type1 Inactive DFGin 8.162 15.602 BLBminus -125.29, 160.66 52.47, 61.82 -60.63, 138.56 279.12, 65.63 -74.82, 135.35 out-out out 15.467 Saltbr-out 12.024 HRD-in -85.09, -48.23 77.57, -22.2 out-out-out SNCooo out-out ActLoopNT-out 9.279 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.87, 148.53 APE9-dihe-na -96.15, 140.05 APE8-dihe-in -88.42, 131.99 APE8-rot-out 198.97 APE67-dihe-in -59.72, -24.59 -102.21, -6.98 APE12-dist-out 19.529 APE11-dist-out 16.258 APE10-dist-out 18.687 APE9-dist-out 10.897 None None OCS177 XRAY 2.0 0.196 0.244 A 306 293 5 0 0 0 [[4, 286]] 1.0 4erw Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EZ3A P24941 1 298 298.0 0S0:301 Type1 Inactive DFGin 7.853 15.267 BLBminus -133.96, 164.73 51.79, 51.75 -53.29, 139.94 283.77, 63.17 -91.21, 154.8 out-out out 15.432 Saltbr-out 11.797 HRD-in -73.94, -47.35 72.9, -19.55 out-out-out SNCooo out-out ActLoopNT-out 9.746 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.13, 71.3 APE9-dihe-na -50.77, 138.23 APE8-dihe-in -127.23, 122.97 APE8-rot-in 280.81 APE67-dihe-in -57.94, -28.97 -97.57, -11.17 APE12-dist-out 18.663 APE11-dist-out 19.324 APE10-dist-out 19.14 APE9-dist-out 11.228 None None None XRAY 2.0 0.215 0.251 A 306 294 4 0 0 0 [[4, 286]] 1.0 4ez3 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4GCJA P24941 1 298 298.0 X64:60305 Type1 Inactive DFGin 7.48 15.445 BLBminus -128.79, 165.13 55.31, 52.44 -58.37, 140.99 280.27, 64.84 -88.27, 148.81 out-out out 14.152 Saltbr-out 11.552 HRD-in -83.59, -49.05 76.02, -17.04 out-out-out SNCooo out-out ActLoopNT-out 10.098 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -62.57, -25.33 APE9-dihe-na -58.46, -30.9 APE8-dihe-out -60.96, -28.7 APE8-rot-out 61.81 APE67-dihe-in -60.38, -24.3 -67.05, -28.87 APE12-dist-out 18.889 APE11-dist-out 15.971 APE10-dist-out 19.84 APE9-dist-out 11.54 None None None XRAY 1.42 0.192 0.205 A 306 298 0 0 0 0 [[4, 286]] 1.0 4gcj Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6GUHA P24941 1 298 298.0 FB8:60301 Type1 Inactive DFGin 8.694 15.809 BLBminus -120.04, 173.52 62.61, 46.47 -54.07, 136.17 282.54, 69.51 -112.2, 71.47 out-out out 15.464 Saltbr-out 12.084 HRD-in -84.89, -57.05 82.23, -6.91 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.39, 131.44 APE9-dihe-na -74.39, 131.26 APE8-dihe-in -71.45, 137.64 APE8-rot-out 183.41 APE67-dihe-in -63.46, -27.01 -101.58, -1.17 APE12-dist-out 19.956 APE11-dist-out 18.042 APE10-dist-out 18.112 APE9-dist-out 10.263 None None None XRAY 1.5 0.201 0.243 A 306 282 16 0 0 8 [[4, 286]] 1.0 6guh Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4D1ZA P24941 3 295 298.0 WG8:1296,WG8:1297 Type1,Allosteric Inactive DFGin 7.655 14.879 BLBminus -138.61, 166.7 53.69, 62.06 -66.35, 146.31 289.12, 61.98 -62.67, 999.0 out-none out 14.426 Saltbr-none 999.0 HRD-in -87.85, -51.36 68.31, -11.6 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -158.52 APE8-rot-in 317.6 APE67-dihe-in -61.54, -25.97 -87.85, -20.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.851 0.195 0.225 A 298 258 35 0 0 17 [[4, 286]] 1.0 4d1z Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5FP5A P24941 1 295 298.0 1Y6:1297,1Y6:1298 Type1,Allosteric Inactive DFGin 7.106 15.112 BLBminus -126.43, 168.67 54.32, 57.13 -56.03, 146.66 281.91, 70.26 -71.22, 108.53 out-none out 14.153 Saltbr-none 999.0 HRD-in -75.97, -52.64 80.13, -21.84 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -61.4 APE8-rot-in 287.38 APE67-dihe-in -57.93, -29.61 -103.75, -5.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.16 0.19 0.253 A 298 264 31 0 0 16 [[4, 286]] 1.0 5fp5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5FP6A P24941 1 294 298.0 MFZ:1295,MFZ:1296 Type1,Allosteric Inactive DFGin 7.159 14.886 BLBminus -139.17, 164.12 57.45, 56.83 -61.36, 140.84 280.63, 65.35 -62.28, 999.0 out-out out 14.255 Saltbr-out 12.885 HRD-in -71.27, -54.68 83.61, -20.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 114.0 APE8-dihe-in -82.84, 129.07 APE8-rot-in 309.53 APE67-dihe-in -59.66, -27.11 -102.64, -3.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.329 None None None XRAY 1.85 0.209 0.24 A 298 278 16 0 0 16 [[4, 286]] 1.0 5fp6 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3PXQA P24941 1 298 298.0 2AN:60300,2AN:60301,2AN:60302 Type1,Allosteric,Type3 Inactive DFGin 6.791 14.958 BLBminus -156.11, 172.24 56.44, 48.4 -58.19, 145.75 280.77, 74.71 -81.02, -171.95 out-out out 17.021 Saltbr-out 15.6 HRD-in -85.93, -53.84 79.73, -15.83 out-out-out SNCooo out-out ActLoopNT-out 10.14 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -155.6, 50.43 APE9-dihe-na -145.4, -64.21 APE8-dihe-out -61.58, -25.66 APE8-rot-out 171.8 APE67-dihe-in -58.56, -25.05 -69.11, -27.97 APE12-dist-out 16.567 APE11-dist-out 17.761 APE10-dist-out 20.389 APE9-dist-out 11.311 None None None XRAY 1.9 0.196 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3pxq Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3PY1A P24941 1 298 298.0 SU9:60300,2AN:60301,2AN:60302 Type1,Allosteric,Type3 Inactive DFGin 6.969 14.582 BLBminus -156.43, 165.09 55.84, 55.34 -63.31, 145.25 285.83, 75.03 -95.3, 141.59 out-out out 15.677 Saltbr-out 11.464 HRD-in -77.3, -51.37 78.87, -23.11 out-out-out SNCooo out-out ActLoopNT-out 9.408 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -116.77, -56.62 APE9-dihe-na -53.47, -37.91 APE8-dihe-out -53.54, -42.42 APE8-rot-in 292.43 APE67-dihe-in -55.86, -28.72 -53.35, -38.93 APE12-dist-in 11.889 APE11-dist-out 15.747 APE10-dist-out 18.483 APE9-dist-out 10.674 None None None XRAY 2.05 0.199 0.251 A 306 298 0 0 0 0 [[4, 286]] 1.0 3py1 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7RWEA P24941 3 298 298.0 7TH:301,7TH:302 Type1,Type3 Inactive DFGin 9.525 14.836 BLBminus -143.06, 174.7 57.85, 50.81 -63.66, 150.13 280.61, 73.06 -93.43, 46.42 none-none none 999.0 Saltbr-none 999.0 HRD-in -84.43, -53.97 80.54, -19.03 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -28.29 APE8-rot-out 191.2 APE67-dihe-in -60.45, -24.39 -100.07, -4.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.59 0.217 0.238 A 298 254 42 0 0 16 [[4, 286]] 1.0 7rwe Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7SA0A P24941 1 298 298.0 8KQ:305,8KQ:306 Type1,Type3 Inactive DFGin 9.605 14.534 BLBminus -154.45, 170.89 59.18, 53.24 -66.44, 148.13 286.95, 61.45 -96.89, 60.62 out-out out 16.349 Saltbr-out 16.233 HRD-in -77.47, -50.62 78.26, -17.98 out-out-out SNCooo out-out ActLoopNT-out 9.355 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 141.94 APE9-dihe-na -88.84, 132.94 APE8-dihe-in -88.27, 121.95 APE8-rot-in 299.98 APE67-dihe-in -59.38, -26.65 -102.3, 0.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.68 APE9-dist-out 11.048 None None None XRAY 1.59 0.196 0.219 A 298 281 17 0 0 6 [[4, 286]] 1.0 7sa0 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8FOWA P24941 3 298 298.0 1QK:303,7TW:304 Type1,Type3 Inactive DFGin 9.603 14.684 BLBminus -142.98, 169.57 62.58, 46.02 -58.43, 140.27 285.17, 73.33 -80.44, 47.06 out-out out 16.793 Saltbr-out 17.874 HRD-in -84.61, -56.26 85.39, -14.19 out-out-out SNCooo out-out ActLoopNT-out 9.539 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -79.82, 130.93 APE9-dihe-na -70.75, 142.04 APE8-dihe-in -94.51, 122.37 APE8-rot-in 301.96 APE67-dihe-in -61.63, -23.3 -100.31, -0.74 APE12-dist-none 999.0 APE11-dist-out 19.404 APE10-dist-out 20.622 APE9-dist-out 10.975 None None None XRAY 1.6 0.205 0.221 A 298 275 21 0 0 9 [[4, 286]] 1.0 8fow Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8FP0A P24941 2 298 298.0 RRC:303,7TW:304 Type1,Type3 Inactive DFGin 9.391 14.948 BLBminus -136.63, 174.45 61.03, 42.96 -56.03, 146.23 280.88, 71.31 -87.4, 49.07 out-out out 16.002 Saltbr-out 16.492 HRD-in -87.02, -54.08 75.17, -13.79 out-out-out SNCooo out-out ActLoopNT-out 9.594 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 140.67 APE9-dihe-na -85.45, 141.48 APE8-dihe-in -84.73, 120.79 APE8-rot-in 296.72 APE67-dihe-in -62.27, -23.72 -95.92, -2.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.323 APE9-dist-out 10.967 None None None XRAY 1.6 0.213 0.24 A 298 274 23 0 0 11 [[4, 286]] 1.0 8fp0 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EZ7A P24941 1 298 298.0 STU:60301,2AN:60302,2AN:60303 Type1,Type3,Allosteric Inactive DFGin 6.978 14.625 BLBminus -145.53, 170.39 52.9, 57.73 -61.57, 149.9 287.28, 68.06 -86.96, 168.33 out-out out 16.748 Saltbr-out 14.413 HRD-in -86.07, -42.21 71.45, -15.9 out-out-out SNCooo out-out ActLoopNT-out 10.236 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -63.47, 156.15 APE9-dihe-na -125.23, 14.23 APE8-dihe-out -63.17, -28.79 APE8-rot-in 293.42 APE67-dihe-in -53.71, -31.99 -57.23, -35.61 APE12-dist-out 18.472 APE11-dist-out 18.425 APE10-dist-out 13.977 APE9-dist-out 11.306 None None None XRAY 2.49 0.22 0.274 A 306 298 0 0 0 0 [[4, 286]] 1.0 4ez7 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7RXOA P24941 3 298 298.0 80E:302 Type3 Inactive DFGin 9.577 15.209 BLBminus -139.06, 169.7 61.6, 49.36 -60.15, 142.75 280.94, 71.13 -90.17, 55.28 out-none out 16.257 Saltbr-none 999.0 HRD-in -84.07, -54.4 80.78, -17.71 none-out-out SNCnoo out-out ActLoopNT-out 9.285 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 128.7 APE9-dihe-na -79.88, 129.58 APE8-dihe-in -82.74, 122.09 APE8-rot-in 299.53 APE67-dihe-in -61.07, -23.59 -103.49, 0.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.234 APE9-dist-out 11.072 None None None XRAY 1.38 0.221 0.233 A 298 266 30 0 0 11 [[4, 286]] 1.0 7rxo Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7S4TA P24941 3 298 298.0 88O:302 Type3 Inactive DFGin 9.489 14.93 BLBminus -139.75, 172.37 54.85, 54.18 -61.18, 140.99 279.06, 68.96 -88.85, 55.03 out-out out 16.133 Saltbr-out 17.267 HRD-in -83.62, -51.24 80.26, -20.24 out-out-out SNCooo out-out ActLoopNT-out 9.773 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.14, 114.43 APE9-dihe-na -104.15, 134.39 APE8-dihe-in -80.41, 117.61 APE8-rot-in 297.25 APE67-dihe-in -59.04, -28.55 -98.31, -2.72 APE12-dist-out 21.83 APE11-dist-out 15.938 APE10-dist-out 19.475 APE9-dist-out 10.954 None None None XRAY 1.91 0.176 0.218 A 298 293 3 0 0 0 [[4, 286]] 1.0 7s4t Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7S7AA P24941 2 298 298.0 8FI:302 Type3 Inactive DFGin 9.329 14.863 BLBminus -135.89, 169.74 57.4, 53.57 -62.05, 140.1 280.75, 73.98 -88.85, 60.5 out-none out 16.295 Saltbr-none 999.0 HRD-in -83.29, -52.56 81.61, -18.34 none-out-out SNCnoo out-out ActLoopNT-out 9.519 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 134.88 APE9-dihe-na -76.39, 137.86 APE8-dihe-in -88.45, 118.46 APE8-rot-in 298.52 APE67-dihe-in -62.81, -25.13 -99.02, 0.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.232 APE9-dist-out 11.121 None None None XRAY 1.7 0.207 0.238 A 298 278 19 0 0 6 [[4, 286]] 1.0 7s7a Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7S84A P24941 1 298 298.0 8IL:301 Type3 Inactive DFGin 9.497 14.909 BLBminus -138.52, 170.26 59.0, 52.71 -61.4, 138.63 280.38, 69.16 -88.44, 57.68 out-out out 16.574 Saltbr-out 16.91 HRD-in -84.23, -49.7 77.31, -14.87 out-out-out SNCooo out-out ActLoopNT-out 9.341 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 132.74 APE9-dihe-na -86.51, 133.78 APE8-dihe-in -79.23, 128.57 APE8-rot-in 299.16 APE67-dihe-in -62.27, -25.49 -106.32, 3.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.695 APE9-dist-out 10.85 None None None XRAY 2.0 0.2 0.244 A 298 282 16 0 0 6 [[4, 286]] 1.0 7s84 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7S85A P24941 3 298 298.0 8IQ:303 Type3 Inactive DFGin 9.781 15.144 BLBminus -134.14, 169.78 58.04, 49.92 -58.53, 139.92 281.4, 68.84 -85.04, 54.66 out-out out 16.939 Saltbr-out 18.208 HRD-in -87.86, -51.53 80.52, -16.15 out-out-out SNCooo out-out ActLoopNT-out 9.384 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 138.57 APE9-dihe-na -72.34, 136.21 APE8-dihe-in -90.62, 126.85 APE8-rot-in 294.4 APE67-dihe-in -60.51, -24.54 -104.08, -3.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.471 APE9-dist-out 10.828 None None None XRAY 1.98 0.208 0.252 A 298 281 15 0 0 6 [[4, 286]] 1.0 7s85 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7S9XA P24941 3 298 298.0 8KF:301 Type3 Inactive DFGin 9.152 14.904 BLBminus -140.51, 174.83 55.24, 52.61 -60.52, 155.06 283.44, 65.83 -96.54, 51.03 out-out out 17.021 Saltbr-out 17.405 HRD-in -80.98, -57.39 84.63, -18.55 out-out-out SNCooo out-out ActLoopNT-out 9.299 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 131.76 APE9-dihe-na -82.0, 133.39 APE8-dihe-in -82.83, 123.04 APE8-rot-in 299.71 APE67-dihe-in -59.76, -23.84 -102.49, -0.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.12 APE9-dist-out 11.022 None None None XRAY 1.69 0.231 0.262 A 298 269 27 0 0 12 [[4, 286]] 1.0 7s9x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7RWFA P24941 1 298 298.0 7TW:60302 Type3 Inactive DFGin 9.475 14.851 BLBminus -140.11, 174.11 55.01, 51.54 -61.58, 141.11 278.46, 73.02 -87.62, 59.54 out-out out 16.189 Saltbr-out 17.439 HRD-in -86.88, -54.95 86.13, -18.41 out-out-out SNCooo out-out ActLoopNT-out 9.866 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -106.87, 114.93 APE9-dihe-na -103.6, 143.12 APE8-dihe-in -86.24, 120.37 APE8-rot-in 298.57 APE67-dihe-in -60.28, -26.78 -101.29, -1.63 APE12-dist-out 21.854 APE11-dist-out 16.026 APE10-dist-out 19.464 APE9-dist-out 10.963 None None None XRAY 1.5 0.193 0.209 A 299 298 0 0 0 0 [[4, 286]] 1.0 7rwf Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7UG1A P24941 1 295 298.0 N5R:60301,N5R:60302 Type3,Allosteric Inactive DFGin 6.692 15.049 BLBminus -154.93, 172.78 49.62, 54.28 -54.44, 144.52 289.06, 72.65 -89.13, 27.85 out-out out 17.046 Saltbr-out 15.958 HRD-in -81.96, -54.91 81.92, -12.71 out-out-out SNCooo out-out ActLoopNT-out 10.411 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -76.84, -22.46 APE9-dihe-na -57.42, -34.71 APE8-dihe-out -59.79, -32.24 APE8-rot-in 307.27 APE67-dihe-in -63.21, -23.7 -63.64, -31.65 APE12-dist-none 999.0 APE11-dist-out 15.205 APE10-dist-out 19.426 APE9-dist-out 11.354 None None None XRAY 1.84 0.185 0.242 A 306 286 9 0 0 3 [[4, 286]] 1.0 7ug1 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKUA P24941 1 298 298.0 60K:60301,60K:60303 Allosteric,Type1 Inactive DFGin 7.532 14.657 BLBplus -135.21, 172.93 58.37, 56.18 -149.13, 168.21 70.31, 113.83 101.63, -8.92 out-out out 14.86 Saltbr-out 13.98 HRD-in -76.61, -52.96 81.36, -19.81 out-out-out SNCooo out-out ActLoopNT-out 9.027 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -122.19, 109.72 APE9-dihe-na -67.24, 137.07 APE8-dihe-in -92.16, 118.49 APE8-rot-in 298.26 APE67-dihe-in -57.53, -28.86 -100.6, -4.39 APE12-dist-out 20.495 APE11-dist-out 16.094 APE10-dist-out 20.291 APE9-dist-out 11.164 None None None XRAY 1.47 0.165 0.192 A 299 293 5 0 0 0 [[4, 286]] 1.0 4fku Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1AQ1A P24941 1 298 298.0 STU:299 Type1 Inactive DFGin 7.283 14.934 BLBplus -138.32, 166.15 50.99, 60.93 -140.99, 149.68 67.4, 106.52 86.86, 1.1 out-out out 14.888 Saltbr-out 13.171 HRD-in -84.88, -53.74 82.51, -14.75 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -59.57, 119.45 APE9-dihe-na -86.87, 141.05 APE8-dihe-in -59.86, 138.54 APE8-rot-out 207.57 APE67-dihe-in -54.1, -30.89 -108.21, -4.5 APE12-dist-none 999.0 APE11-dist-out 16.32 APE10-dist-out 19.124 APE9-dist-out 10.677 None None None XRAY 2.0 0.22 0.26 A 298 277 21 0 0 13 [[4, 286]] 1.0 1aq1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1DI8A P24941 1 298 298.0 DTQ:500 Type1 Inactive DFGin 5.286 12.815 BLBplus -114.54, 155.43 79.27, -0.34 -51.17, 128.46 67.78, 108.22 78.05, -4.2 out-out out 14.831 Saltbr-out 16.347 HRD-in -89.04, -65.58 89.71, -9.68 out-out-out SNCooo out-out ActLoopNT-out 5.844 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -63.21, 81.66 APE9-dihe-na -97.7, 112.93 APE8-dihe-in -52.76, 126.46 APE8-rot-out 188.18 APE67-dihe-in -53.72, -28.56 -112.91, 0.13 APE12-dist-none 999.0 APE11-dist-out 21.044 APE10-dist-out 21.004 APE9-dist-out 11.421 None None None XRAY 2.2 0.186 0.226 A 298 283 15 0 0 9 [[4, 286]] 1.0 1di8 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1FVTA P24941 1 298 298.0 106:299 Type1 Inactive DFGin 5.142 12.898 BLBplus -112.17, 152.94 73.61, 11.22 -57.79, 138.21 65.33, 93.15 69.94, -6.82 out-out out 14.813 Saltbr-out 15.811 HRD-in -87.32, -48.04 73.21, -21.25 out-out-out SNCooo out-out ActLoopNT-out 5.65 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 116.82 APE9-dihe-na -59.95, 148.18 APE8-dihe-in -91.54, 131.39 APE8-rot-in 296.01 APE67-dihe-in -50.93, -28.82 -107.79, -3.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.112 APE9-dist-out 11.11 None None None XRAY 2.2 0.195 0.232 A 298 282 16 0 0 9 [[4, 286]] 1.0 1fvt Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1GIHA P24941 1 298 298.0 1PU:501 Type1 Inactive DFGin 7.603 14.666 BLBplus -132.39, 162.96 73.36, 36.64 -132.47, -179.37 76.86, 142.71 79.81, -17.33 out-out out 14.516 Saltbr-out 16.918 HRD-in -84.83, -56.79 80.14, -22.26 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -3.67 APE8-dihe-in -88.7, 144.41 APE8-rot-out 81.32 APE67-dihe-in -36.89, -39.25 -93.08, -14.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.709 None None None XRAY 2.8 0.221 0.275 A 298 276 22 0 0 14 [[4, 286]] 1.0 1gih Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1JVPP P24941 1 298 298.0 89E:301 Type1 Inactive DFGin 6.673 15.538 BLBplus -124.6, 163.56 49.59, 52.57 -127.98, 161.66 85.8, 105.57 78.71, -9.93 out-out out 15.017 Saltbr-out 13.886 HRD-in -86.56, -53.81 82.69, -21.84 out-out-out SNCooo out-out ActLoopNT-out 5.869 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 128.75 APE9-dihe-na -80.44, 132.95 APE8-dihe-in -77.78, 136.22 APE8-rot-out 187.76 APE67-dihe-in -50.97, -31.59 -104.41, -2.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.42 APE9-dist-out 10.814 None None None XRAY 1.53 0.215 0.253 P 298 281 17 0 0 10 [[4, 286]] 1.0 1jvp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1KE5A P24941 1 298 298.0 LS1:299 Type1 Inactive DFGin 4.799 12.605 BLBplus -119.03, 152.59 68.54, 27.6 -68.18, 143.84 65.51, 82.78 56.33, 8.79 out-out out 14.767 Saltbr-out 16.809 HRD-in -89.54, -69.21 83.16, 3.85 out-out-out SNCooo out-out ActLoopNT-out 5.89 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 128.52 APE9-dihe-na -65.15, 148.86 APE8-dihe-in -84.49, 130.69 APE8-rot-in 301.9 APE67-dihe-in -55.05, -28.17 -106.93, 2.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.158 APE9-dist-out 10.822 None None None XRAY 2.2 0.184 0.224 A 298 281 17 0 0 10 [[4, 286]] 1.0 1ke5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1KE6A P24941 1 298 298.0 LS2:299 Type1 Inactive DFGin 5.226 13.052 BLBplus -114.43, 150.83 81.73, 9.56 -58.76, 131.87 64.85, 102.26 77.93, -15.8 out-out out 15.124 Saltbr-out 16.662 HRD-in -91.16, -66.31 93.51, -11.95 out-out-out SNCooo out-out ActLoopNT-out 5.857 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 118.37 APE8-dihe-in -78.91, 126.34 APE8-rot-in 303.73 APE67-dihe-in -51.88, -29.76 -108.1, 0.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.21 None None None XRAY 2.0 0.191 0.222 A 298 280 18 0 0 11 [[4, 286]] 1.0 1ke6 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1KE7A P24941 1 298 298.0 LS3:299 Type1 Inactive DFGin 5.336 13.1 BLBplus -114.06, 154.6 70.77, 22.75 -68.97, 139.15 60.3, 92.81 71.56, -3.62 out-out out 15.032 Saltbr-out 16.506 HRD-in -94.13, -53.18 77.0, -19.46 out-out-out SNCooo out-out ActLoopNT-out 5.788 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 87.05 APE9-dihe-na -68.48, 130.37 APE8-dihe-in -76.61, 129.99 APE8-rot-out 186.24 APE67-dihe-in -51.76, -28.63 -110.76, -2.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.31 APE9-dist-out 11.271 None None None XRAY 2.0 0.191 0.235 A 298 281 17 0 0 10 [[4, 286]] 1.0 1ke7 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1KE8A P24941 1 298 298.0 LS4:299 Type1 Inactive DFGin 5.502 12.634 BLBplus -115.96, 152.64 68.02, 23.95 -65.53, 134.94 55.59, 92.86 71.55, -0.07 out-out out 14.834 Saltbr-out 15.808 HRD-in -84.69, -51.99 78.68, -23.24 out-out-out SNCooo out-out ActLoopNT-out 5.903 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 116.25 APE9-dihe-na -82.17, 139.92 APE8-dihe-in -83.24, 126.04 APE8-rot-in 300.66 APE67-dihe-in -48.32, -30.5 -104.98, -2.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.11 APE9-dist-out 11.26 None None None XRAY 2.0 0.187 0.228 A 298 282 16 0 0 9 [[4, 286]] 1.0 1ke8 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1KE9A P24941 1 298 298.0 LS5:299 Type1 Inactive DFGin 5.06 12.815 BLBplus -114.57, 155.42 79.31, -0.37 -51.24, 128.45 67.72, 108.23 78.07, -4.16 out-out out 14.388 Saltbr-out 16.019 HRD-in -80.91, -55.23 86.3, -14.41 out-out-out SNCooo out-out ActLoopNT-out 5.727 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 130.15 APE9-dihe-na -79.86, 152.62 APE8-dihe-in -95.68, 120.36 APE8-rot-out 190.48 APE67-dihe-in -52.61, -32.69 -98.66, 3.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.477 APE9-dist-out 11.242 None None None XRAY 2.0 0.203 0.238 A 298 281 17 0 0 10 [[4, 286]] 1.0 1ke9 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1R78A P24941 1 298 298.0 FMD:299 Type1 Inactive DFGin 7.977 14.518 BLBplus -148.21, 162.41 66.71, 48.29 -146.21, 177.7 71.71, 111.12 103.56, 999.0 out-out out 14.502 Saltbr-out 13.771 HRD-in -74.45, -50.27 81.95, -22.67 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 130.68 APE8-dihe-in -91.04, 127.22 APE8-rot-in 297.81 APE67-dihe-in -58.04, -29.23 -104.59, -4.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.064 None None None XRAY 2.0 0.22 0.262 A 298 273 25 0 0 16 [[4, 286]] 1.0 1r78 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2XNBA P24941 1 298 298.0 Y8L:1299 Type1 Inactive DFGin 7.51 14.957 BLBplus -137.53, 161.98 73.43, 53.28 -152.53, 158.55 82.97, 106.55 81.74, -19.61 out-out out 14.788 Saltbr-out 15.928 HRD-in -73.91, -57.47 85.82, -18.04 out-out-out SNCooo out-out ActLoopNT-out 6.607 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -79.88, 155.13 APE9-dihe-na -77.91, 135.78 APE8-dihe-in -83.69, 127.06 APE8-rot-out 190.84 APE67-dihe-in -59.57, -24.22 -99.23, -8.0 APE12-dist-out 20.35 APE11-dist-out 17.997 APE10-dist-out 19.307 APE9-dist-out 10.95 None None None XRAY 1.85 0.216 0.294 A 298 296 2 0 0 0 [[4, 286]] 1.0 2xnb Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4BGHA P24941 1 298 298.0 3I6:1001 Type1 Inactive DFGin 8.718 15.546 BLBplus -115.48, 148.97 82.94, 18.88 -106.55, 167.4 59.8, 171.47 69.4, -14.32 out-out out 14.883 Saltbr-out 14.265 HRD-in -82.41, -56.62 80.05, -25.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 2.36 APE8-dihe-in -96.87, 115.8 APE8-rot-in 284.55 APE67-dihe-in -67.24, -23.77 -97.37, -4.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.262 None None None XRAY 1.95 0.196 0.246 A 298 275 23 0 0 14 [[4, 286]] 1.0 4bgh Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5IEVA P24941 1 298 298.0 R0N:1001 Type1 Inactive DFGin 7.701 14.63 BLBplus -126.88, 158.29 69.51, 57.97 -153.39, -177.6 66.12, 119.16 64.78, -27.02 out-out out 14.55 Saltbr-out 14.279 HRD-in -85.43, -53.53 78.87, -18.3 out-out-out SNCooo out-out ActLoopNT-out 6.09 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 123.47 APE9-dihe-na -63.42, 141.42 APE8-dihe-in -85.25, 137.97 APE8-rot-in 326.09 APE67-dihe-in -61.55, -27.86 -107.7, -2.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.534 APE9-dist-out 10.856 None None None XRAY 2.03 0.198 0.262 A 298 284 14 0 0 9 [[4, 286]] 1.0 5iev Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKWA P24941 1 298 298.0 62K:60301 Type1 Inactive DFGin 7.407 14.925 BLBplus -134.06, 170.99 59.77, 52.01 -144.58, 164.63 70.25, 114.29 98.79, 11.08 out-out out 14.727 Saltbr-out 11.662 HRD-in -78.53, -55.5 82.7, -17.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 129.05 APE9-dihe-na -67.36, 128.3 APE8-dihe-in -82.55, 130.77 APE8-rot-out 182.78 APE67-dihe-in -59.58, -25.87 -102.67, -2.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.458 APE9-dist-out 10.895 None None None XRAY 1.8 0.179 0.204 A 299 280 18 0 0 13 [[4, 286]] 1.0 4fkw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7NVQA P24941 1 294 298.0 STU:301 Type1 Inactive DFGin 7.026 14.701 BLBplus -138.98, 166.91 60.92, 69.03 -161.06, 162.59 72.07, 108.19 128.48, -14.92 out-out out 14.351 Saltbr-out 15.166 HRD-in -80.38, -55.15 83.91, -13.55 out-out-out SNCooo out-out ActLoopNT-out 6.029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.14, 127.57 APE9-dihe-na -77.4, 113.59 APE8-dihe-in -55.3, 141.9 APE8-rot-out 195.1 APE67-dihe-in -55.26, -27.26 -100.43, -4.92 APE12-dist-out 18.864 APE11-dist-out 17.703 APE10-dist-out 18.976 APE9-dist-out 9.89 None None None XRAY 2.05 0.24 0.288 A 300 287 7 0 0 0 [[4, 286]] 1.0 7nvq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q4HA P24941 1 298 298.0 HGH:60301 Type1 Inactive DFGin 5.848 13.451 BLBplus -107.05, 150.63 79.69, 19.7 -54.54, 140.34 50.81, 86.9 78.39, -11.53 out-out out 15.502 Saltbr-out 17.114 HRD-in -89.07, -67.36 89.36, -8.71 out-out-out SNCooo out-out ActLoopNT-out 5.907 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.62, 117.7 APE9-dihe-na -72.78, 143.88 APE8-dihe-in -90.48, 138.99 APE8-rot-out 189.01 APE67-dihe-in -63.59, -22.28 -100.99, -4.64 APE12-dist-out 18.171 APE11-dist-out 17.448 APE10-dist-out 20.035 APE9-dist-out 11.057 None None None XRAY 1.0 0.192 0.207 A 306 290 8 0 0 2 [[4, 286]] 1.0 6q4h Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1GIIA P24941 1 298 298.0 1PU:501 Type1 Inactive DFGin 4.936 13.987 BLBplus -114.59, 156.0 67.87, 18.02 -73.98, 143.78 77.53, 108.5 80.6, -16.5 out-out out 14.793 Saltbr-out 13.858 HRD-in -88.83, -52.17 77.18, -13.7 out-out-out SNCooo out-out ActLoopNT-out 5.816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 96.29 APE8-dihe-in -79.17, 128.38 APE8-rot-out 67.02 APE67-dihe-in -53.29, -28.99 -103.74, 0.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.34 F82H,L83V,K89T None None XRAY 2.0 0.214 0.259 A 298 279 19 0 0 11 [[4, 286]] 1.0 1gii Homo sapiens CMGC_CDK2_HUMAN CMGC 4e-89 305.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1HCKA P24941 1 298 298.0 ATP:400 ATPlike Inactive DFGin 10.521 18.374 BLBtrans -101.64, 156.72 59.01, 28.24 -65.02, 120.2 217.92, 114.75 87.03, -4.22 out-out out 14.886 Saltbr-out 16.602 HRD-in -89.06, -54.55 70.31, -1.71 out-out-out SNCooo out-out ActLoopNT-out 5.768 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.61, 130.9 APE9-dihe-na -79.22, 142.0 APE8-dihe-in -76.12, 133.01 APE8-rot-out 180.79 APE67-dihe-in -48.4, -27.96 -101.36, -7.62 APE12-dist-out 20.077 APE11-dist-out 17.599 APE10-dist-out 19.471 APE9-dist-out 11.031 None None None XRAY 1.9 0.185 0.272 A 298 294 4 0 0 0 [[4, 286]] 1.0 1hck Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8FP5A P24941 2 298 298.0 ATP:302 ATPlike Inactive DFGin 10.376 18.32 BLBtrans -107.51, 151.36 65.27, 30.62 -67.28, 128.54 213.84, 133.39 81.57, 1.02 out-out out 15.796 Saltbr-out 15.873 HRD-in -85.24, -57.92 82.57, -13.18 out-out-out SNCooo out-out ActLoopNT-out 5.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.36, 136.98 APE9-dihe-na -71.53, 131.08 APE8-dihe-in -77.4, 124.67 APE8-rot-in 308.71 APE67-dihe-in -62.7, -24.4 -97.59, -2.61 APE12-dist-out 20.412 APE11-dist-out 17.362 APE10-dist-out 19.075 APE9-dist-out 10.919 None None None XRAY 1.7 0.196 0.23 A 298 288 9 0 0 0 [[4, 286]] 1.0 8fp5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1B38A P24941 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.197 18.302 BLBtrans -95.65, 156.45 60.68, 25.9 -58.03, 132.69 221.26, 95.46 85.91, -14.49 out-out out 15.154 Saltbr-out 16.064 HRD-in -76.6, -58.97 89.85, -20.78 out-out-out SNCooo out-out ActLoopNT-out 6.207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.95, 142.89 APE9-dihe-na -75.18, 129.36 APE8-dihe-in -71.98, 129.31 APE8-rot-out 193.64 APE67-dihe-in -51.99, -31.61 -101.67, -5.99 APE12-dist-out 19.553 APE11-dist-out 17.458 APE10-dist-out 18.673 APE9-dist-out 10.568 None None None XRAY 2.0 0.18 0.25 A 299 290 8 0 0 0 [[4, 286]] 1.0 1b38 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1B39A P24941 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.534 18.343 BLBtrans -101.01, 147.7 73.19, 23.92 -63.93, 137.58 224.37, 103.76 85.74, -27.62 out-out out 15.412 Saltbr-out 16.029 HRD-in -84.44, -53.29 77.56, -15.37 out-out-out SNCooo out-out ActLoopNT-out 5.843 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.65, 122.32 APE9-dihe-na -57.75, 145.92 APE8-dihe-in -67.9, 142.03 APE8-rot-in 290.02 APE67-dihe-in -56.66, -23.98 -105.17, -10.65 APE12-dist-out 20.463 APE11-dist-out 17.183 APE10-dist-out 18.313 APE9-dist-out 9.98 None None None XRAY 2.1 0.2 0.27 A 299 290 8 0 0 0 [[4, 286]] 1.0 1b39 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5OO0A P24941 2 296 298.0 9YZ:301 Allosteric Inactive DFGin 10.457 18.421 BLBtrans -98.86, 154.5 60.87, 27.1 -63.86, 132.51 222.63, 103.78 86.16, -13.27 out-out out 14.661 Saltbr-out 16.591 HRD-in -82.2, -54.82 78.14, -18.7 out-out-out SNCooo out-out ActLoopNT-out 5.703 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.51, 127.66 APE9-dihe-na -78.68, 130.19 APE8-dihe-in -67.86, 144.18 APE8-rot-out 191.22 APE67-dihe-in -63.77, -22.59 -100.18, -3.24 APE12-dist-out 20.036 APE11-dist-out 17.221 APE10-dist-out 18.633 APE9-dist-out 10.38 None None None XRAY 1.6 0.173 0.2 A 303 288 7 0 0 0 [[4, 286]] 1.0 5oo0 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5OSJA P24941 2 296 298.0 AAK:301 Allosteric Inactive DFGin 10.262 18.325 BLBtrans -96.78, 154.16 61.83, 29.6 -66.16, 131.95 219.32, 104.55 85.52, -9.85 out-out out 14.693 Saltbr-out 16.555 HRD-in -84.36, -57.66 76.18, -13.83 out-out-out SNCooo out-out ActLoopNT-out 5.767 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.05, 127.74 APE9-dihe-na -72.89, 127.71 APE8-dihe-in -65.8, 143.08 APE8-rot-out 186.25 APE67-dihe-in -65.51, -22.32 -100.61, 0.36 APE12-dist-out 19.811 APE11-dist-out 17.041 APE10-dist-out 18.542 APE9-dist-out 10.289 None None None XRAY 1.83 0.176 0.222 A 303 292 3 0 0 0 [[4, 286]] 1.0 5osj Homo sapiens CMGC_CDK2_HUMAN CMGC 6.8e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q4KA P24941 1 298 298.0 HHW:60301,HHW:60302 Allosteric,Allosteric Inactive DFGin 10.85 18.405 BLBtrans -100.94, 152.22 71.23, 23.51 -58.99, 137.46 230.56, 102.4 82.0, -6.89 out-out out 15.516 Saltbr-out 17.325 HRD-in -93.17, -61.28 82.46, -13.93 out-out-out SNCooo out-out ActLoopNT-out 5.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.6, 127.33 APE9-dihe-na -72.76, 126.49 APE8-dihe-in -63.97, 143.12 APE8-rot-out 188.4 APE67-dihe-in -64.71, -25.73 -99.22, -3.26 APE12-dist-out 20.235 APE11-dist-out 17.578 APE10-dist-out 18.91 APE9-dist-out 10.441 None None None XRAY 1.06 0.144 0.162 A 306 291 7 0 0 0 [[4, 286]] 1.0 6q4k Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1HCLA P24941 1 298 298.0 No_ligand No_ligand Inactive DFGin 10.261 18.478 BLBtrans -104.5, 152.92 61.36, 30.37 -66.41, 137.4 214.32, 108.69 78.71, -14.68 out-out out 14.93 Saltbr-out 17.86 HRD-in -93.43, -53.59 75.7, -9.41 out-out-out SNCooo out-out ActLoopNT-out 5.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.87, 124.84 APE9-dihe-na -69.95, 134.14 APE8-dihe-in -65.28, 137.06 APE8-rot-out 199.1 APE67-dihe-in -50.97, -34.09 -101.34, -6.77 APE12-dist-out 20.549 APE11-dist-out 17.533 APE10-dist-out 19.298 APE9-dist-out 10.68 None None None XRAY 1.8 0.181 0.254 A 298 294 4 0 0 0 [[4, 286]] 1.0 1hcl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PW2A P24941 1 298 298.0 No_ligand No_ligand Inactive DFGin 10.605 18.352 BLBtrans -101.46, 154.65 61.28, 26.58 -64.34, 136.96 219.75, 106.07 77.58, -3.2 out-out out 15.033 Saltbr-out 16.455 HRD-in -88.6, -57.54 84.26, -15.45 out-out-out SNCooo out-out ActLoopNT-out 5.933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.82, 124.17 APE9-dihe-na -70.75, 130.73 APE8-dihe-in -64.81, 141.74 APE8-rot-out 194.19 APE67-dihe-in -49.12, -31.37 -104.13, -7.85 APE12-dist-out 20.4 APE11-dist-out 17.384 APE10-dist-out 19.026 APE9-dist-out 10.399 None None None XRAY 1.95 0.213 0.249 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pw2 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5ANOA P24941 1 298 298.0 No_ligand No_ligand Inactive DFGin 10.011 17.98 BLBtrans -109.27, 158.79 58.92, 30.89 -72.89, 133.98 208.69, 112.32 71.92, -0.69 out-out out 14.806 Saltbr-out 15.12 HRD-in -77.91, -56.25 82.83, -17.44 out-out-out SNCooo out-out ActLoopNT-out 6.223 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 138.67 APE9-dihe-na -78.35, 134.03 APE8-dihe-in -78.71, 128.62 APE8-rot-out 185.32 APE67-dihe-in -58.9, -25.15 -98.01, -5.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.073 APE9-dist-out 10.707 None None None XRAY 1.7 0.204 0.255 A 298 277 21 0 0 11 [[4, 286]] 1.0 5ano Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EK3A P24941 1 296 298.0 No_ligand No_ligand Inactive DFGin 10.621 18.284 BLBtrans -101.21, 151.46 67.49, 22.05 -57.81, 133.78 228.3, 103.37 82.48, -9.32 out-out out 15.269 Saltbr-out 17.754 HRD-in -88.61, -57.8 87.04, -20.99 out-out-out SNCooo out-out ActLoopNT-out 5.931 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.09, 127.28 APE9-dihe-na -73.13, 128.44 APE8-dihe-in -66.08, 142.79 APE8-rot-out 190.21 APE67-dihe-in -61.92, -26.37 -98.85, -4.9 APE12-dist-out 19.884 APE11-dist-out 17.226 APE10-dist-out 18.698 APE9-dist-out 10.346 None None None XRAY 1.34 0.179 0.19 A 299 288 8 0 0 0 [[4, 286]] 1.0 4ek3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7UXKA P24941 9 294 298.0 No_ligand No_ligand Inactive DFGin 10.989 18.062 BLBtrans -118.57, 168.29 54.94, 39.14 -99.16, 150.1 207.59, 89.89 70.2, 1.9 out-out out 17.637 Saltbr-out 14.639 HRD-in -93.8, -47.18 71.26, -2.37 out-out-out SNCooo out-out ActLoopNT-out 7.125 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.91, -71.71 APE9-dihe-na 58.26, 101.72 APE8-dihe-in -76.67, 124.55 APE8-rot-out 179.93 APE67-dihe-in -64.64, -16.98 -104.38, 3.27 APE12-dist-out 23.663 APE11-dist-out 19.081 APE10-dist-out 19.746 APE9-dist-out 11.527 None None None XRAY 2.63 0.263 0.3 A 299 246 45 0 0 0 [[4, 286]] 1.0 7uxk Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OITA P24941 3 298 298.0 HDT:1299 Type1 Inactive DFGin 10.885 18.174 BLBtrans -105.06, 152.78 71.13, 24.78 -65.66, 139.61 237.85, 106.84 71.25, -1.81 out-out out 15.169 Saltbr-out 13.035 HRD-in -85.02, -54.68 83.17, -16.91 out-out-out SNCooo out-out ActLoopNT-out 5.81 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 136.98 APE9-dihe-na -73.6, 131.55 APE8-dihe-in -74.68, 133.59 APE8-rot-out 204.9 APE67-dihe-in -59.95, -29.35 -105.8, -2.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.623 APE9-dist-out 10.904 None None None XRAY 1.6 0.227 0.24 A 299 273 23 0 0 11 [[4, 286]] 1.0 1oit Homo sapiens CMGC_CDK2_HUMAN CMGC 7.1e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1CKPA P24941 1 298 298.0 PVB:299 Type1 Inactive DFGin 10.658 18.247 BLBtrans -110.41, 150.24 71.15, 24.27 -67.17, 134.25 229.06, 112.41 76.43, -10.92 out-out out 14.934 Saltbr-out 16.231 HRD-in -94.15, -50.27 76.12, -14.13 out-out-out SNCooo out-out ActLoopNT-out 5.838 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -23.52 APE8-dihe-in -85.27, 133.01 APE8-rot-in 300.53 APE67-dihe-in -51.88, -29.25 -105.56, -4.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.845 None None None XRAY 2.05 0.192 0.26 A 298 279 19 0 0 11 [[4, 286]] 1.0 1ckp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H0VA P24941 1 298 298.0 UN4:1299 Type1 Inactive DFGin 10.568 18.251 BLBtrans -95.92, 153.61 60.57, 23.0 -56.36, 130.3 227.88, 99.87 85.5, -9.03 out-out out 15.266 Saltbr-out 16.179 HRD-in -80.8, -62.8 86.19, -12.98 out-out-out SNCooo out-out ActLoopNT-out 5.875 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -79.64, 139.47 APE9-dihe-na -79.99, 133.5 APE8-dihe-in -76.41, 146.34 APE8-rot-out 188.74 APE67-dihe-in -61.68, -24.02 -107.76, 0.04 APE12-dist-none 999.0 APE11-dist-out 16.978 APE10-dist-out 18.767 APE9-dist-out 10.373 None None None XRAY 1.9 0.158 0.234 A 298 288 10 0 0 3 [[4, 286]] 1.0 1h0v Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H0WA P24941 1 298 298.0 207:1299 Type1 Inactive DFGin 10.938 18.295 BLBtrans -110.88, 152.17 71.23, 19.69 -62.64, 131.76 234.97, 88.44 83.07, -13.72 out-out out 15.209 Saltbr-out 15.437 HRD-in -97.61, -53.25 83.54, -20.07 out-out-out SNCooo out-out ActLoopNT-out 5.954 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 109.93 APE8-rot-out 202.71 APE67-dihe-in -61.57, -24.53 -96.03, -0.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.214 0.287 A 298 283 15 0 0 8 [[4, 286]] 1.0 1h0w Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1JSVA P24941 1 298 298.0 U55:400 Type1 Inactive DFGin 10.422 18.557 BLBtrans -103.0, 155.92 63.77, 22.4 -61.9, 118.34 219.35, 111.99 94.76, -3.65 out-out out 15.028 Saltbr-out 16.358 HRD-in -90.22, -56.66 84.87, -23.24 out-out-out SNCooo out-out ActLoopNT-out 6.025 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.77, 126.1 APE9-dihe-na -72.87, 131.2 APE8-dihe-in -67.47, 140.72 APE8-rot-out 185.09 APE67-dihe-in -53.31, -32.81 -106.18, -3.9 APE12-dist-out 19.993 APE11-dist-out 17.479 APE10-dist-out 18.948 APE9-dist-out 10.487 None None None XRAY 1.96 999.0 999.0 A 298 288 10 0 0 0 [[4, 286]] 1.0 1jsv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PXIA P24941 1 298 298.0 CK1:500 Type1 Inactive DFGin 10.897 18.399 BLBtrans -102.28, 152.73 60.72, 30.42 -65.08, 133.41 220.9, 107.51 83.57, -9.56 out-out out 15.118 Saltbr-out 17.565 HRD-in -95.21, -55.86 78.53, -11.29 out-out-out SNCooo out-out ActLoopNT-out 5.676 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.33, 123.92 APE9-dihe-na -70.81, 127.45 APE8-dihe-in -62.48, 142.43 APE8-rot-out 188.84 APE67-dihe-in -51.84, -32.28 -107.42, -0.11 APE12-dist-out 20.689 APE11-dist-out 17.741 APE10-dist-out 19.115 APE9-dist-out 10.433 None None None XRAY 1.95 0.203 0.251 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pxi Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PXJA P24941 1 298 298.0 CK2:500 Type1 Inactive DFGin 10.238 18.323 BLBtrans -108.12, 154.72 59.41, 34.48 -70.19, 130.25 212.07, 108.72 84.22, -11.22 out-out out 15.002 Saltbr-out 19.485 HRD-in -87.43, -51.91 79.87, -15.33 out-out-out SNCooo out-out ActLoopNT-out 5.82 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.98, 124.23 APE9-dihe-na -73.35, 137.11 APE8-dihe-in -70.59, 144.9 APE8-rot-out 191.49 APE67-dihe-in -50.02, -34.42 -112.23, -2.53 APE12-dist-out 20.654 APE11-dist-out 17.589 APE10-dist-out 19.237 APE9-dist-out 10.746 None None None XRAY 2.3 0.21 0.271 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pxj Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PXKA P24941 1 298 298.0 CK3:500 Type1 Inactive DFGin 10.633 18.358 BLBtrans -120.53, 149.99 70.8, 20.93 -68.6, 140.34 208.5, 128.57 68.2, 6.43 out-out out 15.385 Saltbr-out 17.925 HRD-in -95.64, -28.38 63.77, -32.98 out-out-out SNCooo out-out ActLoopNT-out 5.745 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -141.61, 141.31 APE9-dihe-na -65.99, -156.71 APE8-dihe-in -132.29, 131.16 APE8-rot-in 292.3 APE67-dihe-in -43.35, -34.23 -96.72, -15.61 APE12-dist-out 20.668 APE11-dist-out 18.813 APE10-dist-out 18.652 APE9-dist-out 10.683 None None None XRAY 2.8 0.21 0.266 A 298 290 8 0 0 0 [[4, 286]] 1.0 1pxk Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PXLA P24941 1 298 298.0 CK4:500 Type1 Inactive DFGin 10.319 17.894 BLBtrans -106.75, 159.26 54.48, 36.35 -71.0, 141.72 217.81, 113.59 61.53, 0.4 out-out out 14.812 Saltbr-out 16.666 HRD-in -90.63, -45.54 75.31, -14.31 out-out-out SNCooo out-out ActLoopNT-out 5.805 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.02, 137.84 APE9-dihe-na -76.37, 157.28 APE8-dihe-in -111.34, 122.45 APE8-rot-in 287.26 APE67-dihe-in -49.25, -32.38 -102.21, 0.82 APE12-dist-out 20.361 APE11-dist-out 17.316 APE10-dist-out 19.26 APE9-dist-out 11.009 None None None XRAY 2.5 0.21 0.249 A 298 290 8 0 0 0 [[4, 286]] 1.0 1pxl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PXMA P24941 1 298 298.0 CK5:500 Type1 Inactive DFGin 10.494 17.955 BLBtrans -127.08, 145.53 72.49, 39.5 -81.2, 137.28 222.14, 106.81 81.68, -25.06 out-out out 14.709 Saltbr-out 12.258 HRD-in -90.04, -53.5 75.75, -9.0 out-out-out SNCooo out-out ActLoopNT-out 5.586 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -114.35, 122.77 APE9-dihe-na -110.17, 127.38 APE8-dihe-in -85.46, 147.67 APE8-rot-out 49.58 APE67-dihe-in -43.55, -35.48 -95.51, -8.06 APE12-dist-out 20.552 APE11-dist-out 19.349 APE10-dist-out 19.632 APE9-dist-out 10.695 None None None XRAY 2.53 0.225 0.28 A 298 290 8 0 0 0 [[4, 286]] 1.0 1pxm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PXNA P24941 1 298 298.0 CK6:500 Type1 Inactive DFGin 10.103 18.396 BLBtrans -124.71, 142.11 73.33, 24.67 -66.11, 112.31 205.53, 110.77 91.17, -4.77 out-out out 15.55 Saltbr-out 16.119 HRD-in -80.71, -53.56 86.8, -27.65 out-out-out SNCooo out-out ActLoopNT-out 6.006 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -143.37, 111.83 APE9-dihe-na -74.2, -142.96 APE8-dihe-in -161.01, 119.39 APE8-rot-out 178.65 APE67-dihe-in -57.39, -35.33 -89.99, 2.7 APE12-dist-out 19.884 APE11-dist-out 18.531 APE10-dist-out 19.559 APE9-dist-out 11.13 None None None XRAY 2.5 0.24 0.277 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pxn Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PXPA P24941 1 298 298.0 CK8:500 Type1 Inactive DFGin 10.603 17.742 BLBtrans -113.05, 154.9 70.73, 32.65 -74.6, 130.58 226.9, 118.91 82.84, -5.59 out-out out 15.062 Saltbr-out 15.822 HRD-in -86.63, -50.87 79.85, -16.9 out-out-out SNCooo out-out ActLoopNT-out 5.794 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.97, 139.84 APE9-dihe-na -79.23, 137.29 APE8-dihe-in -88.93, 135.37 APE8-rot-out 187.31 APE67-dihe-in -53.16, -23.41 -112.15, 2.68 APE12-dist-out 21.098 APE11-dist-out 18.491 APE10-dist-out 19.363 APE9-dist-out 10.965 None None None XRAY 2.3 0.23 0.273 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pxp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1VYZA P24941 1 298 298.0 N5B:300 Type1 Inactive DFGin 10.688 18.214 BLBtrans -109.49, 154.91 64.84, 32.78 -74.07, 129.55 227.59, 110.86 80.0, -3.59 out-out out 15.296 Saltbr-out 15.452 HRD-in -89.74, -53.71 76.62, -24.24 out-out-out SNCooo out-out ActLoopNT-out 5.759 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -89.53, 120.92 APE9-dihe-na -77.34, 137.58 APE8-dihe-in -73.72, 136.79 APE8-rot-out 193.67 APE67-dihe-in -53.83, -31.46 -107.75, -0.05 APE12-dist-none 999.0 APE11-dist-out 17.214 APE10-dist-out 19.359 APE9-dist-out 10.717 None None None XRAY 2.21 0.238 0.28 A 298 279 19 0 0 8 [[4, 286]] 1.0 1vyz Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1W0XC P24941 1 298 298.0 OLO:1299 Type1 Inactive DFGin 10.635 18.434 BLBtrans -104.48, 149.93 70.96, 24.05 -67.85, 122.98 217.55, 109.56 85.65, -3.99 out-out out 14.815 Saltbr-out 15.461 HRD-in -90.26, -53.28 75.19, -6.69 out-out-out SNCooo out-out ActLoopNT-out 5.645 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 116.93 APE8-dihe-in -66.78, 124.27 APE8-rot-out 58.47 APE67-dihe-in -42.9, -37.07 -89.95, -9.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.546 None None None XRAY 2.2 0.19 0.27 C 298 280 18 0 0 11 [[4, 286]] 1.0 1w0x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1WCCA P24941 1 298 298.0 CIG:1299 Type1 Inactive DFGin 10.586 18.321 BLBtrans -101.25, 153.71 65.29, 26.63 -65.21, 135.37 225.73, 104.14 82.03, -16.28 out-out out 14.979 Saltbr-out 16.921 HRD-in -84.12, -58.51 86.27, -25.3 out-out-out SNCooo out-out ActLoopNT-out 5.935 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 136.37 APE8-dihe-in -68.44, 144.08 APE8-rot-out 189.92 APE67-dihe-in -58.92, -27.89 -101.32, -7.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.634 None None None XRAY 2.2 0.181 0.252 A 298 283 15 0 0 11 [[4, 286]] 1.0 1wcc Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1Y8YA P24941 1 298 298.0 CT7:401 Type1 Inactive DFGin 10.802 18.336 BLBtrans -93.05, 152.29 68.15, 20.21 -59.43, 132.26 231.44, 99.39 87.04, -10.02 out-out out 15.019 Saltbr-out 17.27 HRD-in -92.34, -57.55 83.14, -15.31 out-out-out SNCooo out-out ActLoopNT-out 5.87 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.89, 126.27 APE9-dihe-na -73.81, 132.79 APE8-dihe-in -65.58, 139.9 APE8-rot-in 357.44 APE67-dihe-in -55.44, -30.03 -94.0, -8.51 APE12-dist-out 20.141 APE11-dist-out 17.17 APE10-dist-out 18.868 APE9-dist-out 10.134 None None None XRAY 1.996 0.194 0.272 A 298 292 6 0 0 0 [[4, 286]] 1.0 1y8y Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1Y91A P24941 1 298 298.0 CT9:401 Type1 Inactive DFGin 8.864 16.911 BLBtrans -125.44, 148.26 61.53, 68.01 -127.38, 99.79 187.98, 151.56 96.61, 4.77 out-out out 14.402 Saltbr-out 14.821 HRD-in -75.48, -49.24 84.65, -25.96 out-out-out SNCooo out-out ActLoopNT-out 6.152 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.01, 137.71 APE9-dihe-na -78.47, 147.44 APE8-dihe-in -81.3, 148.72 APE8-rot-out 57.59 APE67-dihe-in -60.75, -24.22 -105.63, -8.34 APE12-dist-out 18.361 APE11-dist-out 17.258 APE10-dist-out 18.486 APE9-dist-out 10.58 None None None XRAY 2.15 0.201 0.295 A 298 286 12 0 0 5 [[4, 286]] 1.0 1y91 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1YKRA P24941 1 298 298.0 628:299 Type1 Inactive DFGin 10.222 18.192 BLBtrans -123.66, 150.21 67.9, 31.8 -75.65, 128.85 216.59, 119.16 83.51, -17.56 out-out out 14.614 Saltbr-out 15.675 HRD-in -77.09, -58.51 83.53, -24.18 out-out-out SNCooo out-out ActLoopNT-out 5.858 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.38, 138.29 APE9-dihe-na -82.48, 131.51 APE8-dihe-in -66.73, 137.13 APE8-rot-out 185.5 APE67-dihe-in -46.84, -30.37 -107.85, -9.08 APE12-dist-out 20.037 APE11-dist-out 17.297 APE10-dist-out 18.959 APE9-dist-out 10.443 None None None XRAY 1.8 0.275 0.271 A 298 298 0 0 0 0 [[4, 286]] 1.0 1ykr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2A0CX P24941 1 298 298.0 CK9:500 Type1 Inactive DFGin 10.368 17.87 BLBtrans -121.46, 148.74 74.57, 23.53 -63.68, 126.4 226.4, 113.11 76.73, -2.49 out-out out 15.046 Saltbr-out 15.708 HRD-in -81.58, -52.61 83.44, -22.41 out-out-out SNCooo out-out ActLoopNT-out 6.079 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.44, 129.98 APE9-dihe-na -82.75, 128.43 APE8-dihe-in -81.81, 146.34 APE8-rot-out 113.9 APE67-dihe-in -60.56, -25.38 -104.96, -6.1 APE12-dist-out 19.304 APE11-dist-out 17.905 APE10-dist-out 19.029 APE9-dist-out 10.501 None None None XRAY 1.95 0.194 0.244 X 298 294 4 0 0 0 [[4, 286]] 1.0 2a0c Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2A4LA P24941 1 298 298.0 RRC:300 Type1 Inactive DFGin 10.578 18.411 BLBtrans -113.59, 145.45 72.4, 28.76 -70.81, 127.39 225.24, 108.51 92.04, -16.08 out-out out 14.805 Saltbr-out 16.652 HRD-in -77.2, -70.83 76.49, 13.56 out-out-out SNCooo out-out ActLoopNT-out 5.706 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.63, 118.77 APE9-dihe-na -67.51, 125.09 APE8-dihe-in -56.92, 143.85 APE8-rot-out 190.58 APE67-dihe-in -61.81, -25.37 -102.66, -1.04 APE12-dist-out 20.053 APE11-dist-out 17.36 APE10-dist-out 19.19 APE9-dist-out 10.465 None None None XRAY 2.4 0.173 0.27 A 298 286 12 0 0 0 [[4, 286]] 1.0 2a4l Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2B53A P24941 1 298 298.0 D23:299 Type1 Inactive DFGin 10.882 18.163 BLBtrans -105.07, 159.12 64.05, 24.72 -63.04, 128.95 225.92, 111.71 75.84, -23.79 out-out out 15.253 Saltbr-out 16.48 HRD-in -79.41, -54.58 56.47, 10.12 out-out-out SNCooo out-out ActLoopNT-out 5.902 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.9, 132.3 APE9-dihe-na -81.38, 149.71 APE8-dihe-in -74.63, 144.34 APE8-rot-out 188.99 APE67-dihe-in -65.39, -20.02 -90.36, -6.23 APE12-dist-out 19.861 APE11-dist-out 17.069 APE10-dist-out 19.106 APE9-dist-out 10.715 None None None XRAY 2.0 0.223 0.273 A 298 294 4 0 0 0 [[4, 286]] 1.0 2b53 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2B54A P24941 1 298 298.0 D05:300 Type1 Inactive DFGin 10.425 18.175 BLBtrans -108.08, 148.55 65.13, 25.93 -58.02, 130.21 219.52, 123.27 68.09, -12.73 out-out out 15.182 Saltbr-out 18.18 HRD-in -77.1, -66.85 92.16, -28.1 out-out-out SNCooo out-out ActLoopNT-out 6.303 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -86.0, 154.69 APE9-dihe-na -36.24, -70.21 APE8-dihe-out 117.83, 111.97 APE8-rot-in 242.96 APE67-dihe-in -58.21, -28.73 -91.0, 1.3 APE12-dist-out 19.844 APE11-dist-out 20.236 APE10-dist-out 18.851 APE9-dist-out 10.408 None None None XRAY 1.85 0.158 0.263 A 298 298 0 0 0 0 [[4, 286]] 1.0 2b54 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2BTRA P24941 1 298 298.0 U73:300 Type1 Inactive DFGin 9.764 17.726 BLBtrans -121.82, 148.54 71.66, 41.31 -85.73, 127.52 209.72, 126.21 68.87, 10.3 out-out out 14.551 Saltbr-out 14.451 HRD-in -75.68, -54.61 83.11, -22.31 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -82.81, 129.34 APE9-dihe-na -76.72, 133.59 APE8-dihe-in -79.67, 136.44 APE8-rot-out 182.55 APE67-dihe-in -67.18, -21.33 -102.97, -4.89 APE12-dist-none 999.0 APE11-dist-out 17.405 APE10-dist-out 19.155 APE9-dist-out 10.688 None None None XRAY 1.85 0.226 0.272 A 298 275 23 0 0 12 [[4, 286]] 1.0 2btr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C68A P24941 1 296 298.0 CT6:1297 Type1 Inactive DFGin 10.76 18.325 BLBtrans -94.64, 152.26 66.7, 20.98 -56.36, 137.22 230.82, 103.49 83.52, -14.96 out-out out 14.985 Saltbr-out 17.123 HRD-in -85.6, -58.37 80.29, -19.26 out-out-out SNCooo out-out ActLoopNT-out 5.755 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -73.85, 124.5 APE9-dihe-na -68.76, 129.84 APE8-dihe-in -65.16, 145.74 APE8-rot-in 347.97 APE67-dihe-in -57.11, -30.73 -103.28, -2.46 APE12-dist-out 20.352 APE11-dist-out 17.744 APE10-dist-out 19.065 APE9-dist-out 10.259 None None None XRAY 1.95 0.185 0.249 A 298 290 6 0 0 0 [[4, 286]] 1.0 2c68 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C69A P24941 1 298 298.0 CT8:1299 Type1 Inactive DFGin 10.415 18.32 BLBtrans -90.57, 151.57 62.61, 28.01 -62.3, 129.63 222.26, 96.56 87.81, -11.92 out-out out 15.281 Saltbr-out 16.105 HRD-in -83.84, -61.73 85.0, -18.92 out-out-out SNCooo out-out ActLoopNT-out 5.88 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -63.82, 130.06 APE9-dihe-na -77.49, 126.35 APE8-dihe-in -72.2, 149.08 APE8-rot-out 64.27 APE67-dihe-in -56.94, -25.1 -106.47, -1.27 APE12-dist-out 20.392 APE11-dist-out 17.64 APE10-dist-out 19.017 APE9-dist-out 10.524 None None None XRAY 2.1 0.21 0.28 A 298 292 6 0 0 0 [[4, 286]] 1.0 2c69 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C6IA P24941 1 298 298.0 DT1:1299 Type1 Inactive DFGin 10.462 18.307 BLBtrans -99.46, 150.69 63.73, 25.39 -61.45, 132.26 223.16, 103.52 80.67, -7.99 out-out out 14.883 Saltbr-out 16.814 HRD-in -84.75, -59.11 84.73, -24.8 out-out-out SNCooo out-out ActLoopNT-out 5.839 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -80.81, 129.22 APE9-dihe-na -72.98, 142.58 APE8-dihe-in -69.39, 141.06 APE8-rot-out 0.75 APE67-dihe-in -60.33, -26.73 -100.82, -3.43 APE12-dist-out 20.812 APE11-dist-out 17.496 APE10-dist-out 19.372 APE9-dist-out 10.651 None None None XRAY 1.8 0.208 0.275 A 298 292 6 0 0 0 [[4, 286]] 1.0 2c6i Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C6KA P24941 1 298 298.0 DT2:1299 Type1 Inactive DFGin 10.434 18.369 BLBtrans -95.81, 155.41 61.87, 21.94 -57.39, 133.32 223.97, 97.37 83.11, -10.49 out-out out 15.056 Saltbr-out 17.417 HRD-in -83.95, -62.86 83.19, -14.52 out-out-out SNCooo out-out ActLoopNT-out 5.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -77.24, 125.28 APE9-dihe-na -72.71, 134.37 APE8-dihe-in -64.9, 140.95 APE8-rot-in 358.04 APE67-dihe-in -57.82, -30.08 -97.62, -4.03 APE12-dist-out 20.649 APE11-dist-out 17.566 APE10-dist-out 19.161 APE9-dist-out 10.525 None None None XRAY 1.9 0.189 0.254 A 298 292 6 0 0 0 [[4, 286]] 1.0 2c6k Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C6LA P24941 1 298 298.0 DT4:1299 Type1 Inactive DFGin 10.158 18.391 BLBtrans -100.45, 154.57 54.48, 33.32 -59.27, 133.99 220.86, 104.35 78.25, -11.95 out-out out 15.211 Saltbr-out 16.864 HRD-in -90.51, -53.62 83.67, -17.08 out-out-out SNCooo out-out ActLoopNT-out 6.067 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.7, 129.61 APE9-dihe-na -79.31, 143.05 APE8-dihe-in -77.96, 139.63 APE8-rot-out 62.29 APE67-dihe-in -50.61, -32.1 -97.33, -6.25 APE12-dist-out 20.31 APE11-dist-out 17.283 APE10-dist-out 19.211 APE9-dist-out 10.707 None None None XRAY 2.3 0.185 0.281 A 298 291 7 0 0 0 [[4, 286]] 1.0 2c6l Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C6MA P24941 1 296 298.0 DT5:1297 Type1 Inactive DFGin 10.737 18.406 BLBtrans -99.56, 151.64 64.8, 23.03 -61.35, 135.89 223.66, 106.68 83.78, -17.16 out-out out 15.099 Saltbr-out 17.495 HRD-in -82.46, -59.33 77.2, -19.23 out-out-out SNCooo out-out ActLoopNT-out 5.632 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.76, 130.16 APE9-dihe-na -74.21, 136.72 APE8-dihe-in -74.65, 138.26 APE8-rot-in 303.83 APE67-dihe-in -54.03, -32.67 -99.18, -6.49 APE12-dist-out 20.875 APE11-dist-out 17.667 APE10-dist-out 19.357 APE9-dist-out 10.485 None None None XRAY 1.9 0.201 0.27 A 298 290 6 0 0 0 [[4, 286]] 1.0 2c6m Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2CLXA P24941 1 298 298.0 F18:1299 Type1 Inactive DFGin 10.588 18.233 BLBtrans -102.39, 162.05 57.48, 23.46 -58.08, 132.34 226.08, 105.77 84.3, -12.61 out-out out 15.003 Saltbr-out 16.115 HRD-in -80.79, -59.4 83.97, -11.26 out-out-out SNCooo out-out ActLoopNT-out 5.89 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -83.03, 139.33 APE9-dihe-na -72.69, 129.82 APE8-dihe-in -70.52, 142.86 APE8-rot-out 190.27 APE67-dihe-in -60.8, -23.74 -103.33, -5.09 APE12-dist-out 19.792 APE11-dist-out 17.554 APE10-dist-out 18.562 APE9-dist-out 10.434 None None None XRAY 1.8 0.18 0.231 A 298 293 5 0 0 0 [[4, 286]] 1.0 2clx Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2DUVA P24941 1 298 298.0 371:501 Type1 Inactive DFGin 10.031 17.781 BLBtrans -116.25, 145.76 75.25, 33.36 -79.03, 116.4 219.7, 127.13 90.83, -5.88 out-out out 14.482 Saltbr-out 15.191 HRD-in -86.09, -48.51 82.04, -25.16 out-out-out SNCooo out-out ActLoopNT-out 5.987 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -15.38 APE8-dihe-in -61.65, 144.55 APE8-rot-in 320.23 APE67-dihe-in -55.57, -25.12 -119.67, -0.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.52 None None None XRAY 2.2 0.264 0.31 A 298 272 26 0 0 13 [[4, 286]] 1.0 2duv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2EXMA P24941 1 298 298.0 ZIP:400 Type1 Inactive DFGin 10.788 18.565 BLBtrans -100.65, 151.13 60.17, 32.11 -66.39, 135.89 219.64, 103.71 75.85, -5.33 out-out out 15.262 Saltbr-out 18.416 HRD-in -94.2, -54.29 65.89, 4.65 out-out-out SNCooo out-out ActLoopNT-out 5.715 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -90.77, 117.53 APE9-dihe-na -63.29, 130.07 APE8-dihe-in -65.88, 138.18 APE8-rot-out 189.6 APE67-dihe-in -56.66, -22.93 -106.35, -1.75 APE12-dist-out 21.055 APE11-dist-out 17.67 APE10-dist-out 19.516 APE9-dist-out 10.681 None None None XRAY 1.8 0.2 0.27 A 298 298 0 0 0 0 [[4, 286]] 1.0 2exm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R64A P24941 1 298 298.0 740:500 Type1 Inactive DFGin 10.346 18.098 BLBtrans -120.32, 149.34 72.4, 29.07 -75.94, 125.74 220.77, 115.04 86.21, -16.87 out-out out 14.75 Saltbr-out 15.678 HRD-in -88.9, -49.6 77.12, -14.1 out-out-out SNCooo out-out ActLoopNT-out 5.984 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -21.46 APE8-dihe-in -80.9, 138.5 APE8-rot-in 305.01 APE67-dihe-in -55.8, -26.36 -111.59, -0.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.919 None None None XRAY 2.3 0.221 0.257 A 298 279 19 0 0 11 [[4, 286]] 1.0 2r64 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UZNA P24941 1 298 298.0 C96:1299 Type1 Inactive DFGin 10.249 18.225 BLBtrans -111.08, 157.15 69.94, 16.94 -64.75, 137.42 221.99, 89.97 72.31, -22.14 out-out out 14.958 Saltbr-out 15.701 HRD-in -74.51, -50.05 78.55, -16.25 out-out-out SNCooo out-out ActLoopNT-out 5.729 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 121.18 APE9-dihe-na -92.03, 119.74 APE8-dihe-in -70.41, 154.56 APE8-rot-out 59.26 APE67-dihe-in -58.36, -30.79 -112.91, 7.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.465 APE9-dist-out 10.792 None None None XRAY 2.3 0.206 0.297 A 298 279 19 0 0 10 [[4, 286]] 1.0 2uzn Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2V0DA P24941 1 298 298.0 C53:1299 Type1 Inactive DFGin 10.516 18.357 BLBtrans -90.76, 153.42 63.43, 25.77 -65.85, 136.11 224.67, 105.43 80.41, -11.53 out-out out 15.218 Saltbr-out 17.829 HRD-in -88.48, -62.53 84.08, -9.99 out-out-out SNCooo out-out ActLoopNT-out 6.036 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.84, 132.62 APE9-dihe-na -78.23, 133.36 APE8-dihe-in -76.41, 151.22 APE8-rot-out 63.9 APE67-dihe-in -58.52, -31.19 -107.7, -0.79 APE12-dist-out 20.61 APE11-dist-out 17.499 APE10-dist-out 19.167 APE9-dist-out 10.549 None None None XRAY 2.2 0.197 0.286 A 298 292 6 0 0 0 [[4, 286]] 1.0 2v0d Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTAA P24941 1 298 298.0 LZ1:1301 Type1 Inactive DFGin 10.244 18.138 BLBtrans -104.45, 152.93 66.32, 26.32 -69.72, 124.46 220.25, 101.96 88.32, -5.61 out-out out 14.874 Saltbr-out 14.93 HRD-in -83.93, -53.12 78.45, -19.94 out-out-out SNCooo out-out ActLoopNT-out 6.148 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.47 APE8-dihe-in -76.65, 133.94 APE8-rot-out 186.51 APE67-dihe-in -62.46, -25.45 -101.56, -6.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.849 None None None XRAY 2.0 0.236 0.28 A 298 278 20 0 0 11 [[4, 286]] 1.0 2vta Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTHA P24941 1 298 298.0 LZ2:1300 Type1 Inactive DFGin 10.287 18.273 BLBtrans -106.71, 150.66 70.62, 25.54 -66.91, 134.3 220.5, 107.59 73.3, -7.87 out-out out 14.696 Saltbr-out 15.634 HRD-in -81.69, -51.97 78.25, -22.9 out-out-out SNCooo out-out ActLoopNT-out 5.972 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -53.91 APE8-dihe-in -67.54, 130.71 APE8-rot-out 187.68 APE67-dihe-in -55.82, -28.32 -96.45, -10.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.681 None None None XRAY 1.9 0.2 0.241 A 298 278 20 0 0 11 [[4, 286]] 1.0 2vth Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTIA P24941 1 298 298.0 LZ3:1299 Type1 Inactive DFGin 10.725 18.188 BLBtrans -110.35, 147.76 74.49, 17.02 -59.73, 132.8 228.42, 109.53 79.35, -10.32 out-out out 14.867 Saltbr-out 17.15 HRD-in -85.9, -54.67 80.77, -23.6 out-out-out SNCooo out-out ActLoopNT-out 5.892 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -11.49 APE9-dihe-na -59.31, 112.3 APE8-dihe-in -77.31, 134.88 APE8-rot-out 193.8 APE67-dihe-in -60.86, -27.25 -104.56, -7.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.393 APE9-dist-out 10.806 None None None XRAY 2.0 0.168 0.199 A 298 280 18 0 0 10 [[4, 286]] 1.0 2vti Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTJA P24941 1 298 298.0 LZ4:1300 Type1 Inactive DFGin 10.942 17.812 BLBtrans -112.48, 145.27 93.11, 19.59 -86.02, 134.26 217.07, 102.87 75.44, 13.46 out-out out 14.92 Saltbr-out 12.128 HRD-in -80.23, -55.69 82.5, -23.97 out-out-out SNCooo out-out ActLoopNT-out 6.312 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -18.44 APE8-dihe-in -66.07, 130.3 APE8-rot-in 307.21 APE67-dihe-in -61.99, -27.74 -96.84, -6.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.942 None None None XRAY 2.2 0.19 0.262 A 298 276 22 0 0 13 [[4, 286]] 1.0 2vtj Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTLA P24941 1 298 298.0 LZ5:1299 Type1 Inactive DFGin 10.572 18.326 BLBtrans -95.19, 158.58 63.54, 21.35 -61.28, 134.23 224.65, 107.42 78.25, -9.64 out-out out 14.986 Saltbr-out 17.624 HRD-in -86.49, -57.46 86.32, -13.65 out-out-out SNCooo out-out ActLoopNT-out 5.937 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -65.76, 124.79 APE9-dihe-na -61.9, 124.78 APE8-dihe-in -64.39, 143.02 APE8-rot-out 186.35 APE67-dihe-in -54.11, -28.95 -100.63, -8.09 APE12-dist-out 20.034 APE11-dist-out 17.595 APE10-dist-out 18.837 APE9-dist-out 10.293 None None None XRAY 2.0 0.182 0.235 A 298 290 8 0 0 0 [[4, 286]] 1.0 2vtl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTMA P24941 1 298 298.0 LZM:1299 Type1 Inactive DFGin 10.448 18.267 BLBtrans -101.32, 161.31 52.39, 30.09 -66.37, 132.5 224.52, 107.45 84.41, -8.96 out-out out 14.54 Saltbr-out 17.417 HRD-in -82.9, -55.22 81.65, -22.34 out-out-out SNCooo out-out ActLoopNT-out 5.977 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.63, 118.4 APE9-dihe-na -55.56, 132.06 APE8-dihe-in -68.18, 138.39 APE8-rot-out 194.59 APE67-dihe-in -52.68, -31.15 -98.48, -10.51 APE12-dist-out 19.912 APE11-dist-out 17.061 APE10-dist-out 18.946 APE9-dist-out 10.572 None None None XRAY 2.25 0.231 0.286 A 298 290 8 0 0 0 [[4, 286]] 1.0 2vtm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTOA P24941 1 298 298.0 LZ8:1299 Type1 Inactive DFGin 10.039 17.924 BLBtrans -108.91, 161.79 70.67, 17.02 -63.88, 134.77 224.21, 116.93 82.51, -17.59 out-out out 14.812 Saltbr-out 14.491 HRD-in -84.16, -55.57 82.44, -8.45 out-out-out SNCooo out-out ActLoopNT-out 6.214 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.4, 128.62 APE9-dihe-na -65.57, 127.71 APE8-dihe-in -64.51, 143.05 APE8-rot-out 180.96 APE67-dihe-in -63.75, -23.85 -104.79, -0.81 APE12-dist-out 16.221 APE11-dist-out 17.84 APE10-dist-out 18.719 APE9-dist-out 10.489 None None None XRAY 2.19 0.178 0.241 A 298 283 15 0 0 8 [[4, 286]] 1.0 2vto Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTPA P24941 1 298 298.0 LZ9:1299 Type1 Inactive DFGin 10.132 18.029 BLBtrans -104.49, 153.05 65.1, 24.04 -59.74, 134.35 220.34, 118.07 73.64, -15.52 out-out out 14.445 Saltbr-out 15.991 HRD-in -77.26, -54.17 79.25, -11.7 out-out-out SNCooo out-out ActLoopNT-out 5.923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -72.1, 128.96 APE9-dihe-na -78.85, 134.77 APE8-dihe-in -71.14, 143.67 APE8-rot-out 185.57 APE67-dihe-in -56.09, -28.32 -107.11, -2.38 APE12-dist-none 999.0 APE11-dist-out 17.345 APE10-dist-out 19.173 APE9-dist-out 10.604 None None None XRAY 2.15 0.189 0.247 A 298 281 17 0 0 9 [[4, 286]] 1.0 2vtp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTRA P24941 1 298 298.0 LZB:1299 Type1 Inactive DFGin 10.582 18.154 BLBtrans -103.84, 155.96 69.48, 14.66 -61.19, 110.05 222.38, 99.71 106.33, -13.63 out-out out 14.983 Saltbr-out 15.404 HRD-in -82.13, -59.82 91.3, -22.94 out-out-out SNCooo out-out ActLoopNT-out 5.729 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -60.45, 137.14 APE9-dihe-na -72.22, 127.52 APE8-dihe-in -65.44, 136.61 APE8-rot-out 185.79 APE67-dihe-in -56.56, -25.41 -95.85, -7.23 APE12-dist-out 19.94 APE11-dist-out 17.332 APE10-dist-out 18.839 APE9-dist-out 10.193 None None None XRAY 1.89 0.209 0.261 A 298 290 8 0 0 0 [[4, 286]] 1.0 2vtr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2VTSA P24941 1 298 298.0 LZC:1299 Type1 Inactive DFGin 10.163 18.23 BLBtrans -119.12, 159.33 60.82, 24.43 -70.34, 115.84 219.94, 123.35 104.26, -22.17 out-out out 14.805 Saltbr-out 17.557 HRD-in -79.85, -53.15 81.89, -18.41 out-out-out SNCooo out-out ActLoopNT-out 5.98 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.34, 127.3 APE9-dihe-na -68.41, 127.95 APE8-dihe-in -65.04, 136.98 APE8-rot-out 190.16 APE67-dihe-in -60.72, -22.35 -99.36, -3.08 APE12-dist-out 17.838 APE11-dist-out 17.552 APE10-dist-out 19.128 APE9-dist-out 10.603 None None None XRAY 1.9 0.212 0.261 A 298 282 16 0 0 8 [[4, 286]] 1.0 2vts Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2W1HA P24941 1 298 298.0 L0F:1299 Type1 Inactive DFGin 10.307 17.775 BLBtrans -130.06, 151.5 79.56, 18.75 -69.93, 141.61 226.73, 121.67 69.65, -12.05 out-out out 14.489 Saltbr-out 16.038 HRD-in -88.39, -56.31 79.17, -16.22 out-out-out SNCooo out-out ActLoopNT-out 5.457 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.46 APE8-dihe-in -76.22, 142.93 APE8-rot-out 186.46 APE67-dihe-in -49.35, -36.85 -110.85, -4.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.805 None None None XRAY 2.15 0.263 0.308 A 298 283 15 0 0 11 [[4, 286]] 1.0 2w1h Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2XMYA P24941 1 298 298.0 CDK:500 Type1 Inactive DFGin 9.506 17.225 BLBtrans -117.75, 160.49 71.73, 41.55 -108.26, 125.38 192.76, 129.27 69.97, 4.64 out-out out 14.773 Saltbr-out 16.98 HRD-in -84.89, -51.15 78.64, -20.0 out-out-out SNCooo out-out ActLoopNT-out 5.777 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -69.87, 141.67 APE9-dihe-na -77.68, 137.44 APE8-dihe-in -77.42, 137.41 APE8-rot-in 308.69 APE67-dihe-in -65.3, -23.26 -104.09, 2.97 APE12-dist-out 20.719 APE11-dist-out 17.904 APE10-dist-out 19.064 APE9-dist-out 10.662 None None None XRAY 1.9 0.192 0.271 A 298 295 3 0 0 0 [[4, 286]] 1.0 2xmy Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3FZ1A P24941 1 298 298.0 B98:299 Type1 Inactive DFGin 10.083 18.037 BLBtrans -118.6, 152.18 64.15, 33.3 -73.55, 125.13 214.73, 110.59 83.76, -5.83 out-out out 15.114 Saltbr-out 13.891 HRD-in -78.55, -50.44 81.59, -23.72 out-out-out SNCooo out-out ActLoopNT-out 6.061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.64, 140.89 APE9-dihe-na -76.81, 120.94 APE8-dihe-in -67.51, 133.31 APE8-rot-out 180.19 APE67-dihe-in -56.59, -25.97 -101.64, -4.23 APE12-dist-out 20.126 APE11-dist-out 17.003 APE10-dist-out 18.909 APE9-dist-out 10.527 None None None XRAY 1.9 0.212 0.259 A 298 284 14 0 0 7 [[4, 286]] 1.0 3fz1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3LE6A P24941 1 294 298.0 2BZ:299 Type1 Inactive DFGin 10.638 18.449 BLBtrans -102.49, 158.82 69.29, 14.76 -61.56, 127.21 218.65, 111.0 90.68, -11.47 out-out out 15.158 Saltbr-out 16.245 HRD-in -81.11, -59.0 87.78, -20.02 out-out-out SNCooo out-out ActLoopNT-out 5.71 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.94, 126.63 APE9-dihe-na -72.89, 125.92 APE8-dihe-in -65.07, 145.22 APE8-rot-out 186.34 APE67-dihe-in -59.6, -24.81 -103.73, -4.84 APE12-dist-out 19.668 APE11-dist-out 17.428 APE10-dist-out 18.924 APE9-dist-out 10.202 None None None XRAY 2.0 0.196 0.248 A 298 283 11 0 0 0 [[4, 286]] 1.0 3le6 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3LFNA P24941 1 298 298.0 A27:299 Type1 Inactive DFGin 10.089 17.665 BLBtrans -125.43, 160.37 77.0, 10.74 -63.35, 141.89 235.1, 113.67 61.92, -8.5 out-out out 14.952 Saltbr-out 16.384 HRD-in -81.9, -51.28 80.02, -30.16 out-out-out SNCooo out-out ActLoopNT-out 6.328 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.56, 125.69 APE9-dihe-na -74.55, 125.84 APE8-dihe-in -67.73, 132.89 APE8-rot-out 199.9 APE67-dihe-in -49.96, -34.34 -104.26, -9.08 APE12-dist-out 18.604 APE11-dist-out 17.226 APE10-dist-out 19.199 APE9-dist-out 10.704 None None None XRAY 2.28 0.19 0.268 A 298 285 13 0 0 9 [[4, 286]] 1.0 3lfn Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3LFQA P24941 1 298 298.0 A28:299 Type1 Inactive DFGin 10.75 18.712 BLBtrans -102.92, 158.26 67.07, 16.29 -65.32, 123.21 221.43, 110.96 95.12, -12.64 out-out out 15.439 Saltbr-out 16.61 HRD-in -84.03, -56.82 81.21, -14.37 out-out-out SNCooo out-out ActLoopNT-out 5.611 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.35, 125.34 APE9-dihe-na -72.15, 126.09 APE8-dihe-in -56.03, 136.4 APE8-rot-out 193.63 APE67-dihe-in -52.01, -33.31 -102.71, -9.78 APE12-dist-out 19.658 APE11-dist-out 17.247 APE10-dist-out 18.861 APE9-dist-out 10.269 None None None XRAY 2.03 0.187 0.241 A 298 289 9 0 0 0 [[4, 286]] 1.0 3lfq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3LFSA P24941 1 298 298.0 A07:299 Type1 Inactive DFGin 10.723 18.749 BLBtrans -100.95, 160.64 60.15, 21.08 -66.79, 119.13 218.62, 110.24 99.72, -14.09 out-out out 15.297 Saltbr-out 15.328 HRD-in -80.77, -57.76 84.69, -12.96 out-out-out SNCooo out-out ActLoopNT-out 5.742 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.56, 123.33 APE9-dihe-na -71.47, 122.87 APE8-dihe-in -54.7, 135.66 APE8-rot-out 202.71 APE67-dihe-in -44.75, -36.68 -101.07, -17.2 APE12-dist-out 19.923 APE11-dist-out 17.537 APE10-dist-out 19.046 APE9-dist-out 10.592 None None None XRAY 2.4 0.184 0.25 A 298 290 8 0 0 0 [[4, 286]] 1.0 3lfs Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3NS9A P24941 3 298 298.0 NS9:0 Type1 Inactive DFGin 10.655 18.344 BLBtrans -104.88, 159.9 69.13, 14.3 -58.32, 131.05 228.88, 99.89 85.42, -14.57 out-out out 15.329 Saltbr-out 15.457 HRD-in -88.02, -56.06 83.3, -13.93 out-out-out SNCooo out-out ActLoopNT-out 5.779 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.64, 135.86 APE9-dihe-na -78.78, 127.68 APE8-dihe-in -68.37, 143.21 APE8-rot-out 190.5 APE67-dihe-in -63.73, -24.13 -102.59, -2.72 APE12-dist-out 19.632 APE11-dist-out 17.29 APE10-dist-out 18.722 APE9-dist-out 10.33 None None None XRAY 1.78 0.205 0.265 A 298 289 7 0 0 0 [[4, 286]] 1.0 3ns9 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3S2PA P24941 1 298 298.0 PMU:500 Type1 Inactive DFGin 10.728 18.276 BLBtrans -115.59, 143.64 80.48, 18.95 -63.27, 136.01 232.47, 114.59 83.89, -19.44 out-out out 14.943 Saltbr-out 14.624 HRD-in -88.04, -38.7 71.57, -19.54 out-out-out SNCooo out-out ActLoopNT-out 5.871 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -22.9 APE8-dihe-in -78.72, 142.39 APE8-rot-in 309.29 APE67-dihe-in -55.83, -25.33 -114.08, 1.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.855 None None None XRAY 2.3 0.246 0.304 A 298 279 19 0 0 11 [[4, 286]] 1.0 3s2p Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3ULIA P24941 1 298 298.0 1N3:299 Type1 Inactive DFGin 9.095 16.895 BLBtrans -122.4, 161.11 57.18, 61.42 -118.68, 96.88 197.31, 137.98 93.34, 2.37 out-out out 14.413 Saltbr-out 13.533 HRD-in -84.65, -55.09 88.22, -19.73 out-out-out SNCooo out-out ActLoopNT-out 6.956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -96.78, 120.01 APE9-dihe-na -69.02, 130.04 APE8-dihe-in -74.02, 136.57 APE8-rot-out 192.05 APE67-dihe-in -63.89, -25.25 -105.81, -1.83 APE12-dist-none 999.0 APE11-dist-out 15.627 APE10-dist-out 19.206 APE9-dist-out 10.563 None None None XRAY 2.0 0.253 0.302 A 298 286 12 0 0 7 [[4, 286]] 1.0 3uli Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3WBLA P24941 1 298 298.0 PDY:302 Type1 Inactive DFGin 10.717 18.373 BLBtrans -103.8, 149.14 67.3, 26.93 -65.23, 140.5 227.39, 108.94 72.84, -9.33 out-out out 14.984 Saltbr-out 15.276 HRD-in -83.29, -54.84 80.46, -20.85 out-out-out SNCooo out-out ActLoopNT-out 5.854 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 114.58 APE9-dihe-na -78.48, 139.33 APE8-dihe-in -74.02, 136.95 APE8-rot-out 196.91 APE67-dihe-in -56.18, -27.92 -102.18, -5.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.257 APE9-dist-out 10.48 None None None XRAY 2.0 0.192 0.249 A 298 283 15 0 0 9 [[4, 286]] 1.0 3wbl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4LYNA P24941 1 298 298.0 1YG:301 Type1 Inactive DFGin 10.516 18.235 BLBtrans -119.41, 150.82 73.54, 17.17 -63.03, 136.35 224.83, 109.35 65.09, -1.73 out-out out 15.029 Saltbr-out 14.755 HRD-in -80.09, -54.97 80.22, -21.72 out-out-out SNCooo out-out ActLoopNT-out 6.015 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 138.69 APE8-dihe-in -72.27, 124.76 APE8-rot-out 163.4 APE67-dihe-in -51.14, -32.54 -100.42, -8.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.897 None None None XRAY 2.0 0.187 0.238 A 298 287 11 0 0 11 [[4, 286]] 1.0 4lyn Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4RJ3A P24941 1 295 298.0 3QS:302 Type1 Inactive DFGin 10.844 18.479 BLBtrans -103.26, 157.57 67.1, 20.45 -61.5, 131.71 229.9, 107.13 88.12, -11.06 out-na out 15.245 Saltbr-na 16.015 HRD-in -86.0, -60.04 83.03, -12.63 na-out-out SNCaoo out-out ActLoopNT-out 5.662 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.8, 126.77 APE9-dihe-na -74.75, 124.45 APE8-dihe-in -64.43, 140.32 APE8-rot-out 189.03 APE67-dihe-in -62.82, -26.74 -95.98, -4.59 APE12-dist-out 19.57 APE11-dist-out 17.127 APE10-dist-out 18.661 APE9-dist-out 10.283 None None ALY33 XRAY 1.63 0.177 0.21 A 298 288 7 0 0 0 [[4, 286]] 1.0 4rj3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5ANDA P24941 2 294 298.0 5JE:1295 Type1 Inactive DFGin 8.274 17.972 BLBtrans -108.56, 154.71 65.26, 24.96 -64.51, 124.84 179.06, 87.03 79.75, -8.42 out-out out 15.275 Saltbr-out 16.992 HRD-in -83.51, -57.35 86.6, -15.4 out-out-out SNCooo out-out ActLoopNT-out 6.246 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 139.45 APE8-dihe-in -89.16, 125.83 APE8-rot-out 204.61 APE67-dihe-in -61.14, -27.5 -92.29, -6.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.133 None None None XRAY 2.3 0.202 0.243 A 298 273 20 0 0 11 [[4, 286]] 1.0 5and Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5ANEA P24941 1 298 298.0 SZL:1299 Type1 Inactive DFGin 10.384 18.042 BLBtrans -98.72, 153.51 62.76, 28.13 -66.67, 130.51 214.15, 104.62 78.54, -1.94 out-out out 14.978 Saltbr-out 17.607 HRD-in -83.35, -63.25 85.3, -7.09 out-out-out SNCooo out-out ActLoopNT-out 5.652 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.52, 131.48 APE9-dihe-na -77.43, 129.29 APE8-dihe-in -69.37, 142.37 APE8-rot-out 187.45 APE67-dihe-in -63.2, -24.6 -96.92, -3.93 APE12-dist-out 19.525 APE11-dist-out 17.429 APE10-dist-out 18.735 APE9-dist-out 9.926 None None None XRAY 1.7 0.207 0.252 A 298 294 4 0 0 0 [[4, 286]] 1.0 5ane Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5ANIA P24941 2 298 298.0 ES4:1299 Type1 Inactive DFGin 8.632 17.921 BLBtrans -100.22, 154.97 64.79, 25.57 -66.16, 128.59 185.17, 94.4 81.8, -7.51 out-out out 15.17 Saltbr-out 18.472 HRD-in -83.13, -60.29 85.98, -16.81 out-out-out SNCooo out-out ActLoopNT-out 5.965 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 138.49 APE9-dihe-na -86.69, 143.39 APE8-dihe-in -86.45, 133.92 APE8-rot-out 194.21 APE67-dihe-in -62.06, -24.3 -102.02, -7.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.068 APE9-dist-out 10.904 None None None XRAY 1.9 0.19 0.233 A 298 280 17 0 0 8 [[4, 286]] 1.0 5ani Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5ANJA P24941 3 298 298.0 ZXC:1299 Type1 Inactive DFGin 10.316 18.422 BLBtrans -96.15, 156.02 57.87, 34.07 -67.32, 126.98 208.38, 110.65 85.39, -7.11 out-out out 15.054 Saltbr-out 17.717 HRD-in -88.18, -56.56 82.52, -15.71 out-out-out SNCooo out-out ActLoopNT-out 5.823 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 135.53 APE9-dihe-na -80.24, 130.39 APE8-dihe-in -72.89, 137.17 APE8-rot-out 186.19 APE67-dihe-in -62.47, -26.78 -99.52, -0.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.984 APE9-dist-out 10.461 None None None XRAY 1.6 0.198 0.229 A 298 291 5 0 0 5 [[4, 286]] 1.0 5anj Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5ANKA P24941 1 298 298.0 RJI:1299 Type1 Inactive DFGin 10.004 18.262 BLBtrans -94.59, 160.52 54.33, 28.13 -69.08, 123.46 208.1, 104.38 89.59, -12.34 out-out out 15.344 Saltbr-out 16.947 HRD-in -82.34, -53.27 72.78, -5.2 out-out-none SNCoon out-none ActLoopNT-out 5.967 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -17.3 APE8-rot-in 304.08 APE67-dihe-in -62.45, -25.31 -60.66, -15.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.197 0.236 A 298 273 25 0 0 12 [[4, 286]] 1.0 5ank Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5IEYA P24941 1 298 298.0 6AE:1001 Type1 Inactive DFGin 10.378 18.215 BLBtrans -114.62, 155.0 62.49, 29.46 -64.65, 133.15 216.83, 113.7 77.69, -6.71 out-out out 14.9 Saltbr-out 14.376 HRD-in -75.94, -63.93 88.74, -13.91 out-out-out SNCooo out-out ActLoopNT-out 5.849 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -87.07, 134.96 APE9-dihe-na -69.57, 124.98 APE8-dihe-in -77.94, 129.25 APE8-rot-out 189.15 APE67-dihe-in -64.17, -21.6 -99.11, -0.55 APE12-dist-none 999.0 APE11-dist-out 18.559 APE10-dist-out 19.237 APE9-dist-out 10.704 None None None XRAY 1.66 0.182 0.225 A 298 286 12 0 0 7 [[4, 286]] 1.0 5iey Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5JQ8A P24941 3 298 298.0 I73:301 Type1 Inactive DFGin 10.584 18.345 BLBtrans -111.9, 145.9 71.11, 24.04 -62.19, 135.44 225.71, 101.49 76.75, -12.86 out-out out 15.069 Saltbr-out 16.494 HRD-in -81.24, -58.14 82.22, -19.75 out-out-out SNCooo out-out ActLoopNT-out 6.036 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -72.45, 129.84 APE9-dihe-na -73.44, 132.24 APE8-dihe-in -75.97, 146.79 APE8-rot-out 187.32 APE67-dihe-in -56.28, -25.19 -112.71, -4.11 APE12-dist-none 999.0 APE11-dist-out 17.147 APE10-dist-out 19.094 APE9-dist-out 10.404 None None None XRAY 1.94 0.197 0.26 A 298 278 18 0 0 9 [[4, 286]] 1.0 5jq8 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6OQIA P24941 1 298 298.0 N14:60301 Type1 Inactive DFGin 9.145 17.407 BLBtrans -126.28, 165.47 59.89, 41.19 -98.84, 122.93 208.17, 144.57 85.1, -12.85 out-out out 15.094 Saltbr-out 14.724 HRD-in -85.38, -45.99 73.3, -6.92 out-out-out SNCooo out-out ActLoopNT-out 6.081 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.72, 136.48 APE9-dihe-na -75.41, 131.36 APE8-dihe-in -71.47, 141.69 APE8-rot-out 182.19 APE67-dihe-in -60.02, -23.25 -107.84, 1.42 APE12-dist-out 19.791 APE11-dist-out 17.627 APE10-dist-out 19.004 APE9-dist-out 10.274 None None None XRAY 2.0 0.2 0.241 A 299 289 9 0 0 0 [[4, 286]] 1.0 6oqi Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8ERNA P24941 1 296 298.0 WQK:60402 Type1 Inactive DFGin 10.439 18.378 BLBtrans -118.55, 157.59 63.45, 35.55 -78.63, 124.58 219.79, 122.83 82.3, -1.34 out-out out 15.638 Saltbr-out 14.653 HRD-in -80.71, -57.4 84.12, -13.85 out-out-out SNCooo out-out ActLoopNT-out 6.128 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.52, 126.92 APE9-dihe-na -73.22, 136.0 APE8-dihe-in -74.96, 142.36 APE8-rot-out 180.44 APE67-dihe-in -62.96, -25.44 -103.97, -1.56 APE12-dist-out 19.887 APE11-dist-out 17.61 APE10-dist-out 19.181 APE9-dist-out 10.636 None None None XRAY 1.64 0.21 0.25 A 299 287 9 0 0 0 [[4, 286]] 1.0 8ern Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5K4JA P24941 1 298 298.0 6QB:60301 Type1 Inactive DFGin 10.014 17.968 BLBtrans -110.55, 159.76 77.32, 19.32 -71.27, 128.01 213.83, 116.19 78.16, -4.69 out-out out 14.877 Saltbr-out 14.447 HRD-in -79.41, -50.42 77.08, -15.7 out-out-out SNCooo out-out ActLoopNT-out 6.011 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -80.0, 132.4 APE9-dihe-na -74.94, 130.59 APE8-dihe-in -80.35, 134.59 APE8-rot-in 295.11 APE67-dihe-in -60.39, -27.31 -100.79, -3.91 APE12-dist-none 999.0 APE11-dist-out 16.727 APE10-dist-out 19.117 APE9-dist-out 10.736 None None None XRAY 1.6 0.18 0.223 A 299 281 17 0 0 10 [[4, 286]] 1.0 5k4j Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1E1VA P24941 1 298 298.0 CMG:60401 Type1 Inactive DFGin 10.7 18.046 BLBtrans -99.24, 155.81 66.87, 24.14 -63.76, 132.18 229.6, 99.82 83.4, -10.92 out-out out 14.791 Saltbr-out 16.833 HRD-in -80.59, -61.19 86.42, -5.25 out-out-out SNCooo out-out ActLoopNT-out 5.888 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.29, 122.71 APE9-dihe-na -66.44, 133.05 APE8-dihe-in -66.6, 142.89 APE8-rot-out 188.61 APE67-dihe-in -57.66, -27.27 -107.35, -0.77 APE12-dist-out 20.128 APE11-dist-out 17.342 APE10-dist-out 18.833 APE9-dist-out 10.254 None None None XRAY 1.95 0.195 0.269 A 299 290 8 0 0 0 [[4, 286]] 1.0 1e1v Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1E1XA P24941 1 298 298.0 NW1:60401 Type1 Inactive DFGin 10.979 17.956 BLBtrans -97.64, 157.77 73.06, 19.32 -55.26, 128.79 234.68, 94.87 75.71, 0.85 out-out out 15.081 Saltbr-out 16.453 HRD-in -92.2, -60.79 83.98, -15.99 out-out-out SNCooo out-out ActLoopNT-out 5.821 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -62.82, 129.95 APE9-dihe-na -80.61, 134.6 APE8-dihe-in -68.67, 134.93 APE8-rot-out 196.27 APE67-dihe-in -57.95, -23.37 -105.9, -3.99 APE12-dist-out 19.47 APE11-dist-out 17.167 APE10-dist-out 18.93 APE9-dist-out 10.403 None None None XRAY 1.85 0.213 0.281 A 299 290 8 0 0 0 [[4, 286]] 1.0 1e1x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1GZ8A P24941 1 298 298.0 MBP:1300 Type1 Inactive DFGin 10.443 18.109 BLBtrans -98.58, 152.57 68.89, 22.47 -64.14, 134.1 219.68, 102.93 81.1, -7.16 out-out out 15.044 Saltbr-out 16.271 HRD-in -86.73, -59.22 79.55, -11.88 out-out-out SNCooo out-out ActLoopNT-out 5.744 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.59, 127.96 APE9-dihe-na -76.18, 124.54 APE8-dihe-in -65.03, 145.76 APE8-rot-out 188.09 APE67-dihe-in -62.43, -28.35 -100.67, -3.14 APE12-dist-out 19.918 APE11-dist-out 17.207 APE10-dist-out 18.672 APE9-dist-out 10.014 None None CSD177 XRAY 1.3 0.153 0.185 A 299 291 7 0 0 0 [[4, 286]] 1.0 1gz8 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OIQA P24941 1 298 298.0 HDU:1299 Type1 Inactive DFGin 10.525 18.059 BLBtrans -139.58, 159.59 69.1, 6.46 -54.74, 137.73 236.8, 108.11 72.21, -12.12 out-out out 14.532 Saltbr-out 14.63 HRD-in -87.74, -56.39 87.44, -26.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.92 APE8-rot-out 189.02 APE67-dihe-in -62.46, -30.39 -108.24, -1.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.229 0.271 A 299 264 34 0 0 16 [[4, 286]] 1.0 1oiq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1OIRA P24941 1 296 298.0 HDY:1298 Type1 Inactive DFGin 10.961 18.565 BLBtrans -105.21, 158.89 70.84, 20.35 -62.04, 126.74 235.25, 106.34 88.7, -8.69 out-na out 15.74 Saltbr-na 16.69 HRD-in -85.97, -61.94 84.44, -12.99 na-out-out SNCaoo out-out ActLoopNT-out 5.635 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.94, 129.22 APE9-dihe-na -76.3, 127.65 APE8-dihe-in -68.45, 143.36 APE8-rot-out 185.35 APE67-dihe-in -63.04, -26.93 -100.98, -1.1 APE12-dist-out 19.443 APE11-dist-out 17.064 APE10-dist-out 18.737 APE9-dist-out 10.536 None None KCX33 XRAY 1.91 0.205 0.241 A 299 287 9 0 0 0 [[4, 286]] 1.0 1oir Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1URWA P24941 1 298 298.0 I1P:61300 Type1 Inactive DFGin 10.454 17.886 BLBtrans -128.9, 152.71 71.9, 33.22 -81.51, 142.79 224.2, 128.23 67.48, -23.02 out-out out 14.801 Saltbr-out 12.24 HRD-in -84.68, -54.56 83.53, -20.34 out-out-out SNCooo out-out ActLoopNT-out 6.051 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 131.56 APE9-dihe-na -78.51, 139.82 APE8-dihe-in -86.11, 137.85 APE8-rot-out 183.94 APE67-dihe-in -50.76, -31.17 -107.42, -3.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.876 APE9-dist-out 11.04 None None None XRAY 1.6 0.22 0.253 A 299 274 24 0 0 11 [[4, 286]] 1.0 1urw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1V1KA P24941 1 298 298.0 3FP:60299 Type1 Inactive DFGin 10.19 17.621 BLBtrans -125.57, 168.64 54.61, 23.05 -54.4, -165.85 213.64, 99.56 -28.29, 96.36 out-out out 15.372 Saltbr-out 10.793 HRD-in -81.8, -52.45 88.54, -21.37 out-out-out SNCooo out-out ActLoopNT-out 8.562 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 123.05 APE9-dihe-na -65.42, 144.62 APE8-dihe-in -94.98, 131.83 APE8-rot-out 161.28 APE67-dihe-in -57.88, -24.5 -103.16, -2.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.248 APE9-dist-out 11.137 None None None XRAY 2.31 0.211 0.269 A 299 277 21 0 0 12 [[4, 286]] 1.0 1v1k Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1W8CA P24941 1 298 298.0 N69:61301 Type1 Inactive DFGin 10.642 18.343 BLBtrans -101.18, 151.28 67.51, 27.92 -61.57, 133.85 226.8, 104.35 84.98, -14.28 out-out out 14.911 Saltbr-out 16.63 HRD-in -85.85, -58.86 84.89, -17.12 out-out-out SNCooo out-out ActLoopNT-out 5.894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -80.73, 123.43 APE9-dihe-na -69.45, 127.62 APE8-dihe-in -68.1, 141.07 APE8-rot-out 186.57 APE67-dihe-in -57.74, -30.12 -102.87, -3.74 APE12-dist-out 20.129 APE11-dist-out 17.389 APE10-dist-out 18.999 APE9-dist-out 10.328 None None CSD177 XRAY 2.05 0.199 0.256 A 299 291 7 0 0 0 [[4, 286]] 1.0 1w8c Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3FA P24941 1 298 298.0 SC8:60501 Type1 Inactive DFGin 10.661 18.447 BLBtrans -98.47, 153.7 67.12, 23.77 -63.21, 134.87 222.5, 102.49 84.2, -12.67 out-out out 15.069 Saltbr-out 16.376 HRD-in -92.88, -57.06 79.84, -15.25 out-out-out SNCooo out-out ActLoopNT-out 5.778 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.33, 129.66 APE9-dihe-na -76.76, 123.22 APE8-dihe-in -59.98, 142.46 APE8-rot-out 189.43 APE67-dihe-in -55.63, -29.96 -99.21, -7.24 APE12-dist-out 19.988 APE11-dist-out 17.381 APE10-dist-out 18.745 APE9-dist-out 10.084 None None None XRAY 1.5 0.205 0.236 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3f Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3GA P24941 1 298 298.0 SC9:60501 Type1 Inactive DFGin 10.85 18.044 BLBtrans -101.2, 155.63 64.03, 23.98 -61.34, 131.64 231.22, 103.88 83.95, -10.27 out-out out 15.05 Saltbr-out 15.854 HRD-in -90.77, -53.86 83.23, -20.56 out-out-out SNCooo out-out ActLoopNT-out 5.869 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.39, 131.88 APE9-dihe-na -79.4, 124.0 APE8-dihe-in -61.77, 143.17 APE8-rot-out 188.75 APE67-dihe-in -55.58, -28.19 -102.38, -7.58 APE12-dist-out 19.601 APE11-dist-out 17.184 APE10-dist-out 18.542 APE9-dist-out 10.37 None None None XRAY 1.55 0.182 0.212 A 299 289 9 0 0 0 [[4, 286]] 1.0 2r3g Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3HA P24941 1 298 298.0 SCE:60501 Type1 Inactive DFGin 10.487 18.05 BLBtrans -103.52, 151.95 66.45, 22.94 -59.13, 127.46 225.8, 104.72 85.98, -12.37 out-out out 15.001 Saltbr-out 15.445 HRD-in -89.0, -57.65 85.02, -19.12 out-out-out SNCooo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -56.14, 129.68 APE9-dihe-na -79.54, 125.55 APE8-dihe-in -64.01, 138.16 APE8-rot-out 192.6 APE67-dihe-in -56.96, -27.59 -101.19, -4.49 APE12-dist-out 19.454 APE11-dist-out 16.941 APE10-dist-out 18.679 APE9-dist-out 10.383 None None None XRAY 1.5 0.196 0.219 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3h Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3IA P24941 1 298 298.0 SCF:60501 Type1 Inactive DFGin 10.929 18.24 BLBtrans -100.61, 149.54 71.45, 21.63 -58.2, 134.86 231.09, 103.4 83.18, -10.48 out-out out 15.057 Saltbr-out 16.345 HRD-in -91.01, -59.76 82.13, -15.3 out-out-out SNCooo out-out ActLoopNT-out 5.707 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.45, 127.61 APE9-dihe-na -74.97, 122.45 APE8-dihe-in -60.32, 144.67 APE8-rot-out 191.76 APE67-dihe-in -59.78, -26.25 -99.25, -5.87 APE12-dist-out 20.169 APE11-dist-out 17.538 APE10-dist-out 18.889 APE9-dist-out 9.991 None None CSD177 XRAY 1.28 0.178 0.202 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3i Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3JA P24941 1 298 298.0 SCJ:60501 Type1 Inactive DFGin 10.953 18.27 BLBtrans -114.1, 146.32 72.9, 23.15 -65.23, 137.05 227.18, 118.23 77.67, -8.73 out-out out 14.942 Saltbr-out 13.278 HRD-in -88.62, -56.28 83.59, -20.34 out-out-out SNCooo out-out ActLoopNT-out 5.848 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -67.21, 131.74 APE9-dihe-na -77.49, 130.71 APE8-dihe-in -68.83, 135.15 APE8-rot-out 195.06 APE67-dihe-in -55.89, -31.05 -103.35, -2.48 APE12-dist-none 999.0 APE11-dist-out 17.275 APE10-dist-out 19.234 APE9-dist-out 10.554 None None CSD177 XRAY 1.65 0.2 0.236 A 299 282 16 0 0 9 [[4, 286]] 1.0 2r3j Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3KA P24941 1 298 298.0 SCQ:60501 Type1 Inactive DFGin 10.642 18.225 BLBtrans -112.38, 153.22 66.63, 25.1 -65.21, 140.32 227.57, 108.04 67.95, -4.84 out-out out 14.969 Saltbr-out 13.736 HRD-in -85.09, -56.84 80.01, -16.78 out-out-out SNCooo out-out ActLoopNT-out 5.831 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na -72.41, 132.59 APE9-dihe-na -78.48, 130.63 APE8-dihe-in -67.26, 135.75 APE8-rot-out 191.27 APE67-dihe-in -52.65, -28.86 -102.21, -4.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.209 APE9-dist-out 10.563 None None CSD177 XRAY 1.7 0.19 0.232 A 299 281 17 0 0 10 [[4, 286]] 1.0 2r3k Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3MA P24941 1 298 298.0 SCX:60501 Type1 Inactive DFGin 10.336 17.989 BLBtrans -114.44, 154.5 64.36, 27.21 -64.77, 129.58 219.81, 110.11 75.78, 0.59 out-out out 14.779 Saltbr-out 13.304 HRD-in -83.44, -56.39 84.88, -17.86 out-out-out SNCooo out-out ActLoopNT-out 5.822 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -73.86, 131.01 APE9-dihe-na -80.36, 124.34 APE8-dihe-in -63.19, 139.82 APE8-rot-out 192.11 APE67-dihe-in -55.39, -28.8 -104.94, -1.79 APE12-dist-none 999.0 APE11-dist-out 16.986 APE10-dist-out 18.79 APE9-dist-out 10.433 None None CSD177 XRAY 1.7 0.187 0.216 A 299 282 16 0 0 9 [[4, 286]] 1.0 2r3m Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3OA P24941 1 298 298.0 2SC:60501 Type1 Inactive DFGin 10.907 18.264 BLBtrans -106.8, 151.12 69.21, 20.64 -59.53, 130.76 233.37, 103.94 83.35, -14.32 out-out out 15.041 Saltbr-out 16.015 HRD-in -88.12, -55.73 82.99, -17.8 out-out-out SNCooo out-out ActLoopNT-out 5.774 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.63, 134.1 APE9-dihe-na -80.22, 121.22 APE8-dihe-in -57.69, 141.45 APE8-rot-out 195.73 APE67-dihe-in -53.3, -28.47 -106.6, -7.16 APE12-dist-out 19.367 APE11-dist-out 17.274 APE10-dist-out 18.543 APE9-dist-out 10.256 None None CSD177 XRAY 1.8 0.189 0.227 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3o Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3PA P24941 1 298 298.0 3SC:60501 Type1 Inactive DFGin 10.373 18.096 BLBtrans -103.73, 154.65 64.46, 27.74 -66.14, 127.17 219.16, 108.22 87.15, -11.8 out-out out 14.968 Saltbr-out 15.549 HRD-in -87.03, -56.62 81.22, -14.37 out-out-out SNCooo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.35, 131.64 APE9-dihe-na -77.8, 130.25 APE8-dihe-in -65.87, 140.83 APE8-rot-out 194.97 APE67-dihe-in -52.22, -31.79 -106.34, -5.59 APE12-dist-out 19.7 APE11-dist-out 17.11 APE10-dist-out 18.702 APE9-dist-out 10.279 None None CSD177 XRAY 1.66 0.187 0.226 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3p Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3QA P24941 1 298 298.0 5SC:60501 Type1 Inactive DFGin 10.512 18.433 BLBtrans -100.67, 151.77 68.64, 21.38 -59.6, 132.77 219.86, 104.61 84.62, -10.28 out-out out 15.164 Saltbr-out 16.381 HRD-in -90.07, -58.44 81.19, -13.46 out-out-out SNCooo out-out ActLoopNT-out 5.722 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.87, 130.09 APE9-dihe-na -75.81, 120.33 APE8-dihe-in -59.08, 142.08 APE8-rot-out 190.22 APE67-dihe-in -58.29, -27.52 -99.28, -5.18 APE12-dist-out 19.775 APE11-dist-out 17.289 APE10-dist-out 18.687 APE9-dist-out 9.959 None None CSD177 XRAY 1.35 0.182 0.202 A 299 289 9 0 0 0 [[4, 286]] 1.0 2r3q Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2W06A P24941 1 298 298.0 FRV:61300 Type1 Inactive DFGin 10.9 18.235 BLBtrans -114.95, 157.61 70.96, 19.37 -66.23, 138.0 226.94, 104.29 76.65, -14.89 out-none out 14.963 Saltbr-none 999.0 HRD-in -90.02, -58.32 84.99, -24.63 none-out-out SNCnoo out-out ActLoopNT-out 5.567 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -86.7, 128.97 APE9-dihe-na -67.97, 140.58 APE8-dihe-in -73.49, 145.56 APE8-rot-out 189.77 APE67-dihe-in -52.32, -34.55 -110.41, 0.62 APE12-dist-none 999.0 APE11-dist-out 18.754 APE10-dist-out 19.51 APE9-dist-out 10.719 None None None XRAY 2.04 0.205 0.234 A 299 282 16 0 0 9 [[4, 286]] 1.0 2w06 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3IG7A P24941 1 298 298.0 EFP:60999 Type1 Inactive DFGin 8.213 17.453 BLBtrans -132.35, 160.03 82.32, -1.99 -50.89, 132.61 196.98, 90.02 72.2, -15.62 out-out out 15.34 Saltbr-out 13.163 HRD-in -72.58, -55.68 84.16, -21.53 out-out-out SNCooo out-out ActLoopNT-out 6.168 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 117.09 APE8-rot-out 182.06 APE67-dihe-in -57.64, -23.91 -98.67, -5.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.209 0.257 A 299 278 20 0 0 12 [[4, 286]] 1.0 3ig7 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4ACMA P24941 1 298 298.0 7YG:61302 Type1 Inactive DFGin 10.781 17.965 BLBtrans -112.58, 148.13 72.17, 28.34 -71.04, 117.13 228.95, 112.04 92.36, -0.32 out-none out 15.008 Saltbr-none 999.0 HRD-in -83.27, -56.83 80.89, -15.76 none-out-out SNCnoo out-out ActLoopNT-out 6.149 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 127.54 APE9-dihe-na -64.12, 121.26 APE8-dihe-in -82.01, 126.96 APE8-rot-in 299.69 APE67-dihe-in -52.71, -31.21 -101.9, -6.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.25 APE9-dist-out 10.881 None None None XRAY 1.63 0.185 0.218 A 299 277 21 0 0 12 [[4, 286]] 1.0 4acm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EK4A P24941 1 296 298.0 1CK:60301 Type1 Inactive DFGin 10.854 18.329 BLBtrans -100.51, 149.8 72.56, 21.33 -57.59, 137.23 234.06, 103.31 81.08, -10.77 out-out out 15.148 Saltbr-out 17.273 HRD-in -86.4, -60.53 82.79, -14.27 out-out-out SNCooo out-out ActLoopNT-out 5.843 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.97, 126.3 APE9-dihe-na -70.85, 129.02 APE8-dihe-in -66.37, 143.77 APE8-rot-out 189.09 APE67-dihe-in -62.27, -27.5 -99.35, -4.14 APE12-dist-out 20.076 APE11-dist-out 17.438 APE10-dist-out 18.841 APE9-dist-out 10.451 None None None XRAY 1.26 0.158 0.184 A 299 287 9 0 0 0 [[4, 286]] 1.0 4ek4 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EK5A P24941 1 298 298.0 03K:60300 Type1 Inactive DFGin 10.921 18.188 BLBtrans -103.77, 152.42 71.03, 21.11 -61.03, 129.99 236.67, 103.22 85.82, -10.8 out-out out 15.004 Saltbr-out 13.63 HRD-in -88.04, -55.76 82.49, -18.49 out-out-out SNCooo out-out ActLoopNT-out 5.972 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.4, 128.7 APE9-dihe-na -73.93, 129.76 APE8-dihe-in -67.04, 137.47 APE8-rot-out 192.08 APE67-dihe-in -58.4, -25.9 -100.33, -4.35 APE12-dist-out 20.111 APE11-dist-out 17.298 APE10-dist-out 18.875 APE9-dist-out 10.552 None None None XRAY 1.6 0.177 0.213 A 299 289 9 0 0 0 [[4, 286]] 1.0 4ek5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EK6A P24941 1 298 298.0 10K:60301 Type1 Inactive DFGin 10.628 18.054 BLBtrans -108.06, 151.93 70.38, 25.25 -61.93, 130.69 232.32, 109.81 80.42, -8.66 out-out out 15.129 Saltbr-out 16.008 HRD-in -86.6, -55.48 82.58, -16.89 out-out-out SNCooo out-out ActLoopNT-out 5.969 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -76.95, 130.77 APE9-dihe-na -76.53, 127.18 APE8-dihe-in -67.2, 137.66 APE8-rot-out 188.94 APE67-dihe-in -59.63, -26.39 -102.15, -1.88 APE12-dist-none 999.0 APE11-dist-out 17.279 APE10-dist-out 18.893 APE9-dist-out 10.439 None None None XRAY 1.52 0.189 0.217 A 299 278 20 0 0 10 [[4, 286]] 1.0 4ek6 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4EK8A P24941 1 298 298.0 16K:60301 Type1 Inactive DFGin 10.722 17.995 BLBtrans -109.5, 155.95 67.88, 29.38 -68.08, 131.38 233.17, 108.24 75.4, -2.75 out-out out 15.148 Saltbr-out 15.944 HRD-in -85.31, -57.76 81.42, -13.21 out-out-out SNCooo out-out ActLoopNT-out 5.913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -85.83, 126.82 APE9-dihe-na -73.32, 127.39 APE8-dihe-in -69.57, 137.21 APE8-rot-out 187.88 APE67-dihe-in -57.43, -25.99 -100.18, -2.52 APE12-dist-none 999.0 APE11-dist-out 17.35 APE10-dist-out 19.192 APE9-dist-out 10.632 None None None XRAY 1.7 0.184 0.215 A 299 281 17 0 0 9 [[4, 286]] 1.0 4ek8 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKGA P24941 1 298 298.0 4CK:60300 Type1 Inactive DFGin 10.936 18.139 BLBtrans -107.41, 153.36 71.13, 22.31 -63.63, 131.11 235.19, 106.34 82.01, -10.12 out-out out 15.077 Saltbr-out 15.468 HRD-in -87.55, -54.08 81.9, -19.96 out-out-out SNCooo out-out ActLoopNT-out 5.947 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.5, 129.23 APE9-dihe-na -75.39, 128.68 APE8-dihe-in -65.92, 137.73 APE8-rot-out 192.39 APE67-dihe-in -57.48, -27.01 -101.94, -3.79 APE12-dist-out 20.127 APE11-dist-out 17.457 APE10-dist-out 18.995 APE9-dist-out 10.49 None None None XRAY 1.51 0.181 0.209 A 299 286 12 0 0 3 [[4, 286]] 1.0 4fkg Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKIA P24941 1 298 298.0 09K:60301 Type1 Inactive DFGin 10.65 18.18 BLBtrans -106.3, 156.63 67.77, 23.12 -61.4, 126.08 229.96, 109.03 82.55, -7.62 out-out out 15.135 Saltbr-out 16.137 HRD-in -86.67, -56.22 82.47, -16.53 out-out-out SNCooo out-out ActLoopNT-out 5.964 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.61, 130.76 APE9-dihe-na -76.57, 129.21 APE8-dihe-in -70.96, 140.03 APE8-rot-out 186.94 APE67-dihe-in -58.1, -24.75 -101.35, -4.88 APE12-dist-out 19.994 APE11-dist-out 17.27 APE10-dist-out 18.828 APE9-dist-out 10.469 None None None XRAY 1.6 0.175 0.198 A 299 287 11 0 0 3 [[4, 286]] 1.0 4fki Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKJA P24941 1 298 298.0 11K:60301 Type1 Inactive DFGin 10.662 18.118 BLBtrans -106.54, 153.3 70.49, 22.57 -62.76, 127.65 230.35, 110.34 77.74, -2.81 out-out out 14.989 Saltbr-out 16.068 HRD-in -84.91, -56.08 81.47, -18.87 out-out-out SNCooo out-out ActLoopNT-out 5.971 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 126.64 APE9-dihe-na -72.37, 129.36 APE8-dihe-in -70.49, 135.34 APE8-rot-out 194.64 APE67-dihe-in -57.08, -26.19 -100.53, -4.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.018 APE9-dist-out 10.548 None None None XRAY 1.63 0.181 0.199 A 299 278 20 0 0 11 [[4, 286]] 1.0 4fkj Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKLA P24941 1 298 298.0 CK2:60300 Type1 Inactive DFGin 10.298 18.454 BLBtrans -97.13, 153.97 64.33, 26.38 -63.89, 127.59 213.16, 110.01 88.41, -9.74 out-out out 15.155 Saltbr-out 16.365 HRD-in -87.84, -59.51 78.56, -8.39 out-out-out SNCooo out-out ActLoopNT-out 5.856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.65, 125.71 APE9-dihe-na -71.35, 128.91 APE8-dihe-in -66.94, 143.31 APE8-rot-out 189.68 APE67-dihe-in -62.22, -28.04 -98.08, -4.44 APE12-dist-out 20.01 APE11-dist-out 17.245 APE10-dist-out 18.752 APE9-dist-out 10.243 None None None XRAY 1.26 0.153 0.183 A 299 291 7 0 0 0 [[4, 286]] 1.0 4fkl Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKPA P24941 1 298 298.0 LS5:60301 Type1 Inactive DFGin 10.421 18.13 BLBtrans -109.07, 148.66 68.57, 31.4 -65.98, 130.02 221.71, 113.06 77.11, -6.92 out-out out 15.119 Saltbr-out 13.261 HRD-in -84.61, -56.13 82.12, -17.36 out-out-out SNCooo out-out ActLoopNT-out 5.982 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 128.13 APE9-dihe-na -65.92, 132.4 APE8-dihe-in -77.18, 137.03 APE8-rot-out 191.59 APE67-dihe-in -56.87, -27.63 -103.85, -4.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.971 APE9-dist-out 10.405 None None None XRAY 1.6 0.185 0.198 A 299 280 18 0 0 10 [[4, 286]] 1.0 4fkp Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKSA P24941 1 296 298.0 46K:60301 Type1 Inactive DFGin 10.828 18.454 BLBtrans -112.06, 149.48 76.57, 20.63 -65.19, 118.75 230.2, 112.05 97.77, -20.35 out-out out 14.989 Saltbr-out 15.227 HRD-in -82.97, -55.97 81.27, -16.68 out-out-out SNCooo out-out ActLoopNT-out 5.952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 131.96 APE9-dihe-na -72.82, 130.43 APE8-dihe-in -72.15, 135.06 APE8-rot-in 310.37 APE67-dihe-in -59.08, -28.91 -101.44, -2.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.169 APE9-dist-out 10.452 None None None XRAY 1.55 0.171 0.183 A 299 275 21 0 0 12 [[4, 286]] 1.0 4fks Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKTA P24941 1 296 298.0 48K:60301 Type1 Inactive DFGin 10.351 18.046 BLBtrans -109.44, 151.1 67.45, 31.19 -67.7, 128.25 218.22, 118.65 80.97, -8.61 out-out out 15.074 Saltbr-out 15.936 HRD-in -83.89, -55.16 81.06, -15.22 out-out-out SNCooo out-out ActLoopNT-out 5.878 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -83.89, 130.3 APE9-dihe-na -71.98, 135.08 APE8-dihe-in -74.64, 138.23 APE8-rot-out 192.64 APE67-dihe-in -58.77, -28.14 -101.27, -2.22 APE12-dist-none 999.0 APE11-dist-out 17.103 APE10-dist-out 18.916 APE9-dist-out 10.396 None None None XRAY 1.6 0.169 0.193 A 299 278 18 0 0 9 [[4, 286]] 1.0 4fkt Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKVA P24941 1 298 298.0 61K:60301 Type1 Inactive DFGin 9.697 17.074 BLBtrans -116.24, 166.42 56.68, 49.13 -66.21, -125.25 234.55, 108.89 -63.2, 29.87 out-out out 15.073 Saltbr-out 14.013 HRD-in -80.3, -55.19 82.8, -16.39 out-out-out SNCooo out-out ActLoopNT-out 6.264 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -87.01, 128.94 APE9-dihe-na -69.41, 127.44 APE8-dihe-in -73.21, 133.19 APE8-rot-in 299.15 APE67-dihe-in -58.35, -25.3 -102.44, -3.09 APE12-dist-none 999.0 APE11-dist-out 17.365 APE10-dist-out 19.496 APE9-dist-out 10.697 None None None XRAY 1.7 0.177 0.203 A 299 282 16 0 0 11 [[4, 286]] 1.0 4fkv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3PJ8A P24941 1 298 298.0 404:60299 Type1 Inactive DFGin 10.97 18.772 BLBtrans -107.78, 156.84 69.08, 18.02 -66.97, 133.81 224.59, 103.86 71.6, 7.97 out-out out 14.976 Saltbr-out 16.309 HRD-in -88.87, -56.74 88.08, -24.7 out-out-out SNCooo out-out ActLoopNT-out 5.89 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 133.19 APE9-dihe-na -61.77, 138.14 APE8-dihe-in -79.74, 138.07 APE8-rot-out 182.29 APE67-dihe-in -60.66, -26.06 -106.53, -3.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.99 APE9-dist-out 10.926 None None None XRAY 1.96 0.206 0.273 A 299 287 11 0 0 8 [[4, 286]] 1.0 3pj8 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7VDUA P24941 1 296 298.0 65L:60301 Type1 Inactive DFGin 10.895 18.558 BLBtrans -97.63, 158.27 65.67, 19.39 -67.16, 129.16 225.15, 112.44 87.97, -11.91 out-na out 15.376 Saltbr-na 16.202 HRD-in -85.75, -59.87 79.8, -6.3 na-out-out SNCaoo out-out ActLoopNT-out 5.598 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -69.56, 126.12 APE9-dihe-na -74.42, 120.79 APE8-dihe-in -60.87, 141.08 APE8-rot-out 190.37 APE67-dihe-in -61.73, -29.69 -97.28, -3.08 APE12-dist-out 19.647 APE11-dist-out 17.134 APE10-dist-out 18.718 APE9-dist-out 10.008 None None KCX33 XRAY 1.53 0.18 0.217 A 300 289 7 0 0 0 [[4, 286]] 1.0 7vdu Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8OY2A P24941 2 297 298.0 W5W:301 Type1 Inactive DFGin 10.69 18.806 BLBtrans -110.82, 153.52 63.95, 34.31 -90.46, 119.79 213.0, 119.4 87.33, 8.06 out-out out 15.708 Saltbr-out 13.993 HRD-in -74.33, -64.81 90.27, -45.73 out-out-out SNCooo out-out ActLoopNT-out 6.093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 148.96 APE9-dihe-na -84.43, 138.09 APE8-dihe-in -74.05, 144.09 APE8-rot-out 78.44 APE67-dihe-in -56.35, -26.84 -109.72, 10.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.979 APE9-dist-out 11.025 None None None XRAY 2.618 0.223 0.283 A 300 274 22 0 0 12 [[4, 286]] 1.0 8oy2 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QQLA P24941 1 298 298.0 X03:299 Type1 Inactive DFGin 10.822 18.466 BLBtrans -115.27, 159.37 71.14, 15.47 -57.16, 133.91 230.1, 104.83 81.07, -8.2 out-out out 15.659 Saltbr-out 16.312 HRD-in -89.63, -55.48 80.09, -13.92 out-out-out SNCooo out-out ActLoopNT-out 5.729 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -69.18, 126.48 APE9-dihe-na -74.42, 125.11 APE8-dihe-in -61.52, 141.32 APE8-rot-out 189.44 APE67-dihe-in -51.23, -30.77 -103.6, -7.33 APE12-dist-out 19.563 APE11-dist-out 17.225 APE10-dist-out 18.668 APE9-dist-out 10.445 None None None XRAY 1.85 0.184 0.224 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qql Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QZFA P24941 1 298 298.0 X66:299 Type1 Inactive DFGin 10.672 17.904 BLBtrans -112.72, 156.45 66.24, 28.61 -69.72, 139.26 232.19, 106.48 75.36, -9.82 out-out out 15.137 Saltbr-out 15.677 HRD-in -86.74, -51.62 76.1, -18.84 out-out-out SNCooo out-out ActLoopNT-out 5.602 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -51.36, 134.1 APE9-dihe-na -84.99, 144.28 APE8-dihe-in -80.53, 139.01 APE8-rot-out 199.26 APE67-dihe-in -50.56, -24.28 -107.41, -5.58 APE12-dist-out 20.439 APE11-dist-out 17.429 APE10-dist-out 18.904 APE9-dist-out 10.757 None None None XRAY 2.0 0.213 0.272 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qzf Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R8LA P24941 1 298 298.0 Z30:423 Type1 Inactive DFGin 10.246 18.2 BLBtrans -134.72, 146.41 77.58, 31.29 -69.92, 121.18 220.55, 119.67 79.34, 10.81 out-out out 15.309 Saltbr-out 15.06 HRD-in -83.18, -54.17 82.54, -21.73 out-out-out SNCooo out-out ActLoopNT-out 5.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -153.15, 131.45 APE9-dihe-na -74.39, 129.55 APE8-dihe-in -79.53, 131.11 APE8-rot-out 184.04 APE67-dihe-in -54.0, -25.33 -106.05, 1.09 APE12-dist-out 20.108 APE11-dist-out 17.829 APE10-dist-out 18.812 APE9-dist-out 10.698 None None None XRAY 1.9 0.217 0.263 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r8l Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R8PA P24941 1 298 298.0 Z46:511 Type1 Inactive DFGin 10.833 18.411 BLBtrans -109.86, 156.59 70.81, 17.77 -61.23, 140.34 230.73, 100.53 77.63, -12.24 out-out out 15.519 Saltbr-out 16.646 HRD-in -89.15, -57.25 84.1, -18.93 out-out-out SNCooo out-out ActLoopNT-out 5.655 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.46, 129.48 APE9-dihe-na -76.63, 129.87 APE8-dihe-in -65.61, 141.91 APE8-rot-out 190.16 APE67-dihe-in -54.29, -28.21 -102.13, -7.0 APE12-dist-out 19.67 APE11-dist-out 17.313 APE10-dist-out 18.759 APE9-dist-out 10.426 None None None XRAY 1.8 0.184 0.218 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r8p Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5MHQA P24941 1 298 298.0 8QT:60301 Type1 Inactive DFGin 10.509 17.958 BLBtrans -105.1, 155.28 71.0, 19.82 -61.49, 132.7 231.75, 105.0 87.38, -12.37 out-na out 15.824 Saltbr-na 14.592 HRD-in -87.81, -60.42 85.21, -14.08 na-out-out SNCaoo out-out ActLoopNT-out 5.852 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.26, 127.09 APE9-dihe-na -74.2, 125.36 APE8-dihe-in -67.97, 142.68 APE8-rot-out 187.95 APE67-dihe-in -66.07, -24.19 -98.86, -1.32 APE12-dist-out 19.512 APE11-dist-out 17.076 APE10-dist-out 18.57 APE9-dist-out 10.452 None None KCX33 XRAY 1.3 0.19 0.226 A 306 289 9 0 0 0 [[4, 286]] 1.0 5mhq Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q4CA P24941 1 298 298.0 HH8:60301 Type1 Inactive DFGin 10.803 18.281 BLBtrans -99.7, 151.19 74.85, 22.65 -57.9, 138.98 239.02, 98.87 71.58, -4.6 out-out out 15.77 Saltbr-out 16.722 HRD-in -88.21, -60.63 80.87, -13.25 out-out-out SNCooo out-out ActLoopNT-out 5.858 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.34, 128.11 APE9-dihe-na -74.88, 130.64 APE8-dihe-in -71.7, 136.54 APE8-rot-out 190.87 APE67-dihe-in -66.44, -25.99 -93.82, -2.36 APE12-dist-out 20.184 APE11-dist-out 17.867 APE10-dist-out 19.012 APE9-dist-out 10.574 None None None XRAY 1.73 0.182 0.223 A 306 291 7 0 0 0 [[4, 286]] 1.0 6q4c Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1GIJA P24941 1 298 298.0 2PU:501 Type1 Inactive DFGin 9.874 16.956 BLBtrans -133.88, 175.66 55.54, 39.88 -99.33, 167.53 215.57, 128.6 35.6, 17.2 out-out out 15.016 Saltbr-out 16.285 HRD-in -89.8, -57.62 82.38, -25.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.42 APE8-dihe-in -72.31, 128.8 APE8-rot-in 296.43 APE67-dihe-in -49.91, -31.83 -105.85, -6.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.223 F82H,L83V,K89T None None XRAY 2.2 0.242 0.286 A 298 273 25 0 0 14 [[4, 286]] 1.0 1gij Homo sapiens CMGC_CDK2_HUMAN CMGC 4e-89 305.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2DS1A P24941 1 298 298.0 1CD:501 Type1 Inactive DFGin 10.437 18.3 BLBtrans -116.61, 153.42 67.48, 18.7 -63.18, 129.4 214.48, 110.45 81.76, -11.8 out-out out 14.78 Saltbr-out 14.169 HRD-in -83.84, -50.82 81.37, -22.83 out-out-out SNCooo out-out ActLoopNT-out 5.912 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.66, 129.47 APE9-dihe-na -68.92, 130.97 APE8-dihe-in -66.77, 137.82 APE8-rot-out 181.43 APE67-dihe-in -52.71, -31.71 -102.76, -4.74 APE12-dist-out 19.873 APE11-dist-out 17.505 APE10-dist-out 18.889 APE9-dist-out 10.336 F82H,L83V,K89T None None XRAY 2.0 0.225 0.29 A 298 290 8 0 0 0 [[4, 286]] 1.0 2ds1 Homo sapiens CMGC_CDK2_HUMAN CMGC 4e-89 305.2 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q4DA P24941 1 296 298.0 HHT:301,HHT:302,HHT:303,HHT:304,HHT:305,HHT:306 Type1,Allosteric,Allosteric,Allosteric,Allosteric,Allosteric Inactive DFGin 10.559 18.619 BLBtrans -98.54, 149.88 64.48, 29.51 -69.88, 122.17 209.22, 109.84 93.91, -3.77 out-out out 15.528 Saltbr-out 17.097 HRD-in -86.94, -59.39 82.9, -16.25 out-out-out SNCooo out-out ActLoopNT-out 5.57 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.19, 133.26 APE9-dihe-na -69.37, 119.77 APE8-dihe-in -73.96, 108.23 APE8-rot-out 208.44 APE67-dihe-in -63.17, -24.21 -82.02, -5.64 APE12-dist-out 17.75 APE11-dist-out 17.034 APE10-dist-out 19.43 APE9-dist-out 10.791 None None None XRAY 1.07 0.157 0.177 A 306 289 7 0 0 0 [[4, 286]] 1.0 6q4d Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H01A P24941 1 296 298.0 FAL:301,FBL:302 Type1,Type1 Inactive DFGin 10.989 18.669 BLBtrans -111.49, 156.28 70.46, 17.96 -61.52, 133.26 223.32, 110.33 84.91, -12.83 out-na out 15.414 Saltbr-na 15.476 HRD-in -88.66, -59.28 85.0, -16.53 na-out-out SNCaoo out-out ActLoopNT-out 5.564 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.09, 127.84 APE9-dihe-na -75.44, 122.46 APE8-dihe-in -59.62, 143.81 APE8-rot-out 189.61 APE67-dihe-in -49.16, -32.93 -105.49, -7.46 APE12-dist-out 19.636 APE11-dist-out 17.282 APE10-dist-out 18.785 APE9-dist-out 10.152 None None KCX33 XRAY 1.79 0.19 0.219 A 298 287 9 0 0 0 [[4, 286]] 1.0 1h01 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H00A P24941 1 298 298.0 FAP:61300,FCP:61400 Type1,Type1 Inactive DFGin 10.336 18.129 BLBtrans -123.51, 147.17 75.12, 35.25 -78.01, 108.88 223.44, 120.16 83.89, 11.84 out-none out 14.983 Saltbr-none 999.0 HRD-in -86.56, -52.14 80.46, -19.02 none-out-out SNCnoo out-out ActLoopNT-out 6.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -87.75, 124.68 APE9-dihe-na -69.44, 130.06 APE8-dihe-in -74.25, 136.12 APE8-rot-out 186.91 APE67-dihe-in -51.8, -27.34 -105.51, -4.65 APE12-dist-none 999.0 APE11-dist-out 18.077 APE10-dist-out 19.664 APE9-dist-out 10.718 None None None XRAY 1.6 0.208 0.242 A 299 278 20 0 0 10 [[4, 286]] 1.0 1h00 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H07A P24941 1 296 298.0 MFP:60301,MFQ:60302 Type1,Type1 Inactive DFGin 10.287 18.438 BLBtrans -119.42, 153.85 64.96, 30.03 -72.68, 131.31 213.72, 116.73 81.14, -11.07 out-out out 15.176 Saltbr-out 13.566 HRD-in -85.11, -52.28 81.58, -23.62 out-out-out SNCooo out-out ActLoopNT-out 5.936 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -68.92, 134.14 APE9-dihe-na -79.75, 128.98 APE8-dihe-in -65.26, 139.96 APE8-rot-out 188.54 APE67-dihe-in -47.39, -29.23 -107.81, -9.22 APE12-dist-out 20.048 APE11-dist-out 17.372 APE10-dist-out 18.984 APE9-dist-out 10.507 None None None XRAY 1.85 0.21 0.235 A 299 285 11 0 0 4 [[4, 286]] 1.0 1h07 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1H08A P24941 1 298 298.0 BYP:60299,BWP:60300 Type1,Type1 Inactive DFGin 10.365 17.913 BLBtrans -121.38, 159.43 65.2, 23.42 -67.57, 133.78 220.49, 119.07 72.58, -5.9 out-out out 14.987 Saltbr-out 13.18 HRD-in -85.18, -56.92 88.26, -24.57 out-out-out SNCooo out-out ActLoopNT-out 5.938 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.22, 137.45 APE9-dihe-na -81.14, 125.93 APE8-dihe-in -68.9, 135.86 APE8-rot-out 181.79 APE67-dihe-in -51.97, -29.71 -106.74, -2.02 APE12-dist-out 20.425 APE11-dist-out 17.598 APE10-dist-out 19.42 APE9-dist-out 10.698 None None None XRAY 1.8 0.213 0.242 A 299 283 15 0 0 7 [[4, 286]] 1.0 1h08 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8BYAA P24941 16 296 298.0 No_ligand No_ligand Inactive DFGin 6.962 16.292 None -134.63, 82.03 -161.61, 106.37 -138.09, 26.66 284.26, 105.76 -68.14, -60.43 out-none out 10.062 Saltbr-none 999.0 HRD-out -108.07, -22.97 56.97, -114.32 none-out-out SNCnoo out-out ActLoopNT-out 4.301 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -82.31, 123.39 APE9-dihe-na -125.74, 132.38 APE8-dihe-in -58.14, 137.63 APE8-rot-in 294.3 APE67-dihe-in -69.0, -10.69 -52.48, -40.96 APE12-dist-in 11.325 APE11-dist-out 6.447 APE10-dist-out 9.14 APE9-dist-out 7.129 None TPO159 TPO159 EM 3.38 999.0 999.0 A 298 277 16 0 0 0 [[4, 286]] 1.0 8bya Homo sapiens CMGC_CDK2_HUMAN CMGC 6.1e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5UQ1C P24941 1 289 298.0 No_ligand No_ligand Inactive DFGin 6.596 15.653 None -143.1, 67.57 -125.34, 19.31 -94.36, 26.08 301.42, 106.66 -81.71, -31.95 in-in in 9.3 Saltbr-in 3.187 HRD-in -81.67, -52.04 53.83, 40.34 in-in-out SNCiio in-out ActLoopNT-in 2.783 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiii APE10-dihe-na -139.61, -123.49 APE9-dihe-na -60.35, 138.62 APE8-dihe-in -67.73, 105.22 APE8-rot-out 72.15 APE67-dihe-out -22.19, -25.42 16.7, -96.86 APE12-dist-in 12.299 APE11-dist-in 8.652 APE10-dist-in 7.54 APE9-dist-in 3.945 None None None XRAY 3.201 0.208 0.261 C 301 289 0 0 0 0 [[4, 286]] 1.0 5uq1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5OO1A P24941 4 298 298.0 9Z2:301 Type1 Inactive DFGin 7.637 16.022 None -121.17, 166.43 66.4, 43.63 -62.57, 999.0 279.44, 78.94 999.0, 999.0 out-out out 15.44 Saltbr-out 10.782 HRD-in -81.97, -55.23 75.2, -10.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 155.58 APE8-dihe-out -76.46, -29.98 APE8-rot-in 295.35 APE67-dihe-in -58.08, -20.66 -40.64, -49.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.166 F80C,C177A None None XRAY 2.0 0.187 0.236 A 303 278 17 0 0 17 [[4, 286]] 1.0 5oo1 Homo sapiens CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PYEA P24941 1 298 298.0 PM1:700 Type1 Inactive DFGin 8.22 15.465 None -124.58, 165.75 48.02, 64.22 -62.08, 999.0 279.52, 59.87 999.0, 999.0 out-out out 15.012 Saltbr-out 12.46 HRD-in -83.61, -50.44 78.62, -18.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 167.42 APE9-dihe-na -72.88, 127.15 APE8-dihe-in -72.71, 140.05 APE8-rot-out 63.06 APE67-dihe-in -52.66, -26.74 -106.34, -2.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.547 None None None XRAY 2.0 0.239 0.252 A 298 266 32 0 0 16 [[4, 286]] 1.0 1pye Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2W05A P24941 1 298 298.0 FRT:1299 Type1 Inactive DFGin 8.905 15.929 None -128.23, 165.06 62.24, 43.64 -62.21, -101.33 274.85, 83.58 96.54, -134.12 out-out out 15.011 Saltbr-out 13.58 HRD-in -86.31, -48.92 76.7, -14.9 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -141.95, 27.61 APE9-dihe-na -84.15, 133.89 APE8-dihe-in -68.78, 136.67 APE8-rot-out 189.07 APE67-dihe-in -51.29, -28.78 -104.64, -0.82 APE12-dist-none 999.0 APE11-dist-out 16.582 APE10-dist-out 19.183 APE9-dist-out 10.372 None None None XRAY 1.9 0.23 0.293 A 298 276 22 0 0 13 [[4, 286]] 1.0 2w05 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5D1JA P24941 1 298 298.0 56H:4000 Type1 Inactive DFGin 8.637 15.284 None -137.97, 170.56 53.49, 55.77 -71.24, 999.0 283.47, 73.89 999.0, 999.0 out-none out 14.929 Saltbr-none 999.0 HRD-in -80.57, -53.12 79.22, -17.55 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.54 APE8-dihe-in -86.85, 121.49 APE8-rot-in 299.19 APE67-dihe-in -55.62, -31.72 -100.82, -4.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.155 None None None XRAY 1.8 0.203 0.232 A 298 265 33 0 0 17 [[4, 286]] 1.0 5d1j Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QL8A P24941 1 298 298.0 X01:300 Type1 Inactive DFGin 9.132 15.435 None -122.25, 168.91 72.46, -145.11 131.38, -129.83 255.48, 110.66 -62.05, 95.07 out-out out 15.566 Saltbr-out 15.206 HRD-in -84.45, -59.47 81.38, -15.8 out-out-out SNCooo out-out ActLoopNT-out 6.609 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -83.89, 109.54 APE9-dihe-na -59.93, 129.67 APE8-dihe-in -81.59, 123.65 APE8-rot-in 299.9 APE67-dihe-in -51.56, -28.22 -100.19, -8.52 APE12-dist-out 19.719 APE11-dist-out 16.758 APE10-dist-out 19.035 APE9-dist-out 11.061 None None None XRAY 1.9 0.202 0.238 A 306 294 4 0 0 0 [[4, 286]] 1.0 3ql8 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QWJA P24941 1 298 298.0 X6A:483 Type1 Inactive DFGin 10.828 18.605 None -114.29, 146.98 65.6, 42.02 -53.47, -101.22 231.88, 79.31 -68.75, 30.41 out-out out 15.345 Saltbr-out 12.427 HRD-in -84.5, -56.26 82.9, -19.63 out-out-out SNCooo out-out ActLoopNT-out 6.131 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.81, 125.39 APE9-dihe-na -71.61, 131.09 APE8-dihe-in -83.22, 123.55 APE8-rot-in 295.87 APE67-dihe-in -56.8, -26.34 -103.15, 1.31 APE12-dist-out 20.289 APE11-dist-out 17.631 APE10-dist-out 19.675 APE9-dist-out 10.989 None None None XRAY 1.75 0.206 0.229 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qwj Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QX4A P24941 1 298 298.0 X4B:454 Type1 Inactive DFGin 10.988 18.339 None -117.48, 147.66 64.55, 41.52 -55.77, -90.1 235.01, 81.0 -76.36, 28.96 out-out out 15.635 Saltbr-out 14.18 HRD-in -81.9, -60.6 86.28, -21.21 out-out-out SNCooo out-out ActLoopNT-out 5.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -65.97, 121.02 APE9-dihe-na -66.55, 127.88 APE8-dihe-in -80.02, 120.64 APE8-rot-in 297.75 APE67-dihe-in -54.34, -28.48 -100.67, -3.24 APE12-dist-out 20.085 APE11-dist-out 17.422 APE10-dist-out 19.69 APE9-dist-out 10.935 None None None XRAY 1.92 0.205 0.238 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qx4 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R9HA P24941 1 298 298.0 Z67:606 Type1 Inactive DFGin 8.303 15.287 None -120.0, 168.79 77.09, -84.14 71.52, 122.55 279.89, 89.71 -46.26, -69.21 out-out out 14.776 Saltbr-out 14.153 HRD-in -82.5, -51.28 73.26, -15.2 out-out-out SNCooo out-out ActLoopNT-out 7.868 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -57.18, 102.97 APE9-dihe-na -66.25, 137.88 APE8-dihe-in -87.27, 136.09 APE8-rot-in 301.21 APE67-dihe-in -49.8, -36.88 -111.15, -2.68 APE12-dist-out 20.724 APE11-dist-out 17.674 APE10-dist-out 20.037 APE9-dist-out 11.097 None None None XRAY 2.1 0.214 0.259 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r9h Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RK5A P24941 1 298 298.0 07Z:436 Type1 Inactive DFGin 8.254 15.151 None -135.71, 162.54 80.12, -66.74 62.53, 4.94 282.99, 77.39 53.28, -132.52 out-out out 14.736 Saltbr-out 13.125 HRD-in -80.28, -56.17 79.56, -17.53 out-out-out SNCooo out-out ActLoopNT-out 7.575 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.64, 108.95 APE9-dihe-na -69.16, 141.75 APE8-dihe-in -86.76, 130.53 APE8-rot-in 282.62 APE67-dihe-in -51.32, -32.2 -101.03, -6.74 APE12-dist-out 20.054 APE11-dist-out 16.563 APE10-dist-out 18.845 APE9-dist-out 11.032 None None None XRAY 2.0 0.206 0.238 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rk5 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RK7A P24941 1 298 298.0 08Z:467 Type1 Inactive DFGin 8.229 15.161 None -129.7, 167.95 74.53, -59.76 60.9, 15.2 281.75, 75.35 53.86, -103.4 out-out out 14.887 Saltbr-out 15.025 HRD-in -81.84, -56.89 82.92, -16.54 out-out-out SNCooo out-out ActLoopNT-out 7.676 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.0, 97.8 APE9-dihe-na -61.23, 134.9 APE8-dihe-in -84.34, 129.91 APE8-rot-in 290.25 APE67-dihe-in -55.99, -28.83 -103.41, -0.58 APE12-dist-out 20.856 APE11-dist-out 17.133 APE10-dist-out 19.578 APE9-dist-out 11.061 None None None XRAY 1.8 0.206 0.224 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rk7 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RKBA P24941 1 298 298.0 12Z:457 Type1 Inactive DFGin 7.962 15.344 None -136.32, 169.7 52.72, 57.61 -64.16, -102.19 278.37, 71.06 -78.55, 125.67 out-out out 15.318 Saltbr-out 13.622 HRD-in -80.71, -50.21 81.81, -22.27 out-out-out SNCooo out-out ActLoopNT-out 8.929 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.87, 109.93 APE9-dihe-na -69.0, 132.49 APE8-dihe-in -79.46, 128.25 APE8-rot-out 184.86 APE67-dihe-in -52.12, -32.05 -102.56, -4.29 APE12-dist-out 17.061 APE11-dist-out 14.007 APE10-dist-out 16.788 APE9-dist-out 11.04 None None None XRAY 2.0 0.207 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rkb Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RM6A P24941 1 298 298.0 18Z:478 Type1 Inactive DFGin 8.595 15.48 None -127.31, 175.21 70.31, -63.24 64.35, 17.5 284.18, 82.41 61.96, 14.33 out-out out 15.713 Saltbr-out 17.431 HRD-in -88.48, -59.71 83.31, -19.73 out-out-out SNCooo out-out ActLoopNT-out 6.257 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -75.49, 112.67 APE9-dihe-na -67.84, 129.1 APE8-dihe-in -77.92, 125.13 APE8-rot-out 171.09 APE67-dihe-in -52.76, -26.7 -104.02, -2.64 APE12-dist-out 19.203 APE11-dist-out 15.598 APE10-dist-out 18.772 APE9-dist-out 11.131 None None None XRAY 1.6 0.22 0.241 A 306 293 5 0 0 0 [[4, 286]] 1.0 3rm6 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3S0OA P24941 1 298 298.0 50Z:446 Type1 Inactive DFGin 8.504 14.987 None -136.17, 174.47 56.71, 50.73 -53.6, 999.0 285.42, 58.7 999.0, 999.0 out-out out 15.686 Saltbr-out 14.141 HRD-in -92.71, -50.76 76.76, -17.93 out-out-out SNCooo out-out ActLoopNT-out 5.722 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -76.57, 93.08 APE9-dihe-na -52.85, 136.54 APE8-dihe-in -88.54, 130.77 APE8-rot-out 176.51 APE67-dihe-in -49.84, -33.28 -101.8, -5.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.035 None None None XRAY 2.0 0.213 0.271 A 306 293 5 0 0 2 [[4, 286]] 1.0 3s0o Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8RU8A P24941 1 298 298.0 I74:301 Type1 Inactive DFGin 8.492 15.372 None -138.93, 165.19 64.8, 51.39 -61.53, 999.0 281.7, 71.9 999.0, 999.0 out-out out 15.21 Saltbr-out 14.407 HRD-in -79.32, -55.83 85.03, -22.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -92.95, 127.12 APE9-dihe-na -56.69, 130.27 APE8-dihe-in -92.47, 122.83 APE8-rot-in 301.98 APE67-dihe-in -63.56, -25.08 -104.73, 1.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.257 I10L,T14Q,V64I,K88E,K89V,D92K,Q131N None None XRAY 1.51 0.205 0.241 A 306 275 23 0 0 14 [[4, 286]] 1.0 8ru8 Homo sapiens CMGC_CDK2_HUMAN CMGC 1.5e-88 303.3 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3EZRA P24941 1 298 298.0 EZR:300,EZR:301 Type1,Allosteric Inactive DFGin 10.139 18.131 None -127.03, 166.36 56.16, 26.16 -69.94, 999.0 212.22, 111.94 999.0, 999.0 out-out out 14.98 Saltbr-out 15.44 HRD-in -76.59, -53.67 86.14, -23.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.39 APE8-rot-out 187.95 APE67-dihe-in -60.61, -23.99 -102.93, -2.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.208 0.243 A 300 273 25 0 0 18 [[4, 286]] 1.0 3ezr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5A14A P24941 1 296 298.0 LQ5:61297,LQ5:61298 Type2,Allosteric Inactive DFGout 16.189 8.578 None -142.75, 171.68 -138.74, 99.61 -93.91, 17.83 195.09, 58.2 -60.92, 125.74 in-in in 8.372 Saltbr-in 2.841 HRD-in -65.77, -62.64 84.1, -18.65 in-out-out SNCioo out-out ActLoopNT-out 15.046 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 102.43 APE8-dihe-in -81.63, 144.13 APE8-rot-out 74.04 APE67-dihe-in -61.27, -29.59 -107.38, -0.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.171 None None None XRAY 2.0 0.197 0.24 A 299 284 12 0 0 10 [[4, 286]] 1.0 5a14 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q3FA P24941 1 298 298.0 HEW:60301 Allosteric Inactive None 11.361 18.485 None -100.23, 146.03 76.96, 22.05 -56.57, 140.57 248.16, 89.95 83.91, -13.62 out-out out 15.364 Saltbr-out 17.74 HRD-in -87.95, -62.63 79.68, -15.73 out-out-out SNCooo out-out ActLoopNT-out 5.734 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.97, 126.52 APE9-dihe-na -73.61, 124.69 APE8-dihe-in -63.01, 140.77 APE8-rot-out 188.63 APE67-dihe-in -61.19, -27.7 -97.02, -5.86 APE12-dist-out 20.244 APE11-dist-out 17.605 APE10-dist-out 18.911 APE9-dist-out 10.278 None None OCS177 XRAY 1.18 0.163 0.189 A 306 289 9 0 0 0 [[4, 286]] 1.0 6q3f Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q49A P24941 1 298 298.0 HGQ:402 Allosteric Inactive None 11.685 18.287 None -102.71, 149.23 81.53, 18.71 -53.72, 141.75 260.6, 87.13 82.9, -13.25 out-out out 15.606 Saltbr-out 17.027 HRD-in -92.34, -62.66 83.92, -15.17 out-out-out SNCooo out-out ActLoopNT-out 5.883 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -56.92, 142.28 APE9-dihe-na -102.94, 76.38 APE8-dihe-in -27.85, 126.48 APE8-rot-in 312.85 APE67-dihe-in -63.54, -23.09 -100.36, -3.16 APE12-dist-none 999.0 APE11-dist-out 18.124 APE10-dist-out 19.328 APE9-dist-out 10.711 None None None XRAY 1.0 0.176 0.197 A 306 287 11 0 0 5 [[4, 286]] 1.0 6q49 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1BUHA P24941 1 294 298.0 No_ligand No_ligand Inactive None 11.466 18.426 None -112.91, 155.37 66.6, 26.15 -71.37, 139.52 251.03, 90.58 74.51, -2.49 out-out out 16.028 Saltbr-out 16.53 HRD-in -106.58, -47.16 68.81, -29.93 out-out-out SNCooo out-out ActLoopNT-out 6.184 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -90.4, 120.25 APE9-dihe-na -61.56, 166.63 APE8-dihe-in -97.12, 112.03 APE8-rot-in 292.08 APE67-dihe-in -38.64, -29.38 -79.29, -29.19 APE12-dist-out 19.831 APE11-dist-out 18.055 APE10-dist-out 19.892 APE9-dist-out 11.06 None None None XRAY 2.6 0.19 0.25 A 298 287 7 0 0 0 [[4, 286]] 1.0 1buh Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3PXRA P24941 1 298 298.0 No_ligand No_ligand Inactive None 11.449 18.212 None -108.67, 148.57 74.26, 20.64 -60.7, 145.93 248.03, 94.08 71.76, -11.33 out-out out 15.618 Saltbr-out 16.06 HRD-in -87.7, -57.28 81.45, -23.23 out-out-out SNCooo out-out ActLoopNT-out 5.643 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -69.38, 108.05 APE9-dihe-na -62.96, 126.43 APE8-dihe-in -77.47, 127.15 APE8-rot-in 292.83 APE67-dihe-in -51.66, -30.8 -103.08, -6.14 APE12-dist-out 20.448 APE11-dist-out 16.274 APE10-dist-out 19.528 APE9-dist-out 10.817 None None None XRAY 2.0 0.201 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3pxr Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q4IA P24941 1 298 298.0 HGK:302 Type1 Inactive None 12.098 18.408 None -99.36, 137.19 84.12, 26.37 -69.75, 135.57 246.02, 97.85 90.07, -16.34 out-out out 15.636 Saltbr-out 17.437 HRD-in -93.72, -60.37 85.29, -19.56 out-out-out SNCooo out-out ActLoopNT-out 5.843 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -72.57, 111.89 APE9-dihe-na -68.89, 135.45 APE8-dihe-in -83.49, 131.66 APE8-rot-in 320.5 APE67-dihe-in -63.59, -24.06 -101.41, -3.71 APE12-dist-out 18.994 APE11-dist-out 16.989 APE10-dist-out 19.986 APE9-dist-out 11.167 None None None XRAY 1.11 0.166 0.192 A 306 288 10 0 0 3 [[4, 286]] 1.0 6q4i Homo sapiens CMGC_CDK2_HUMAN CMGC 1.5e-89 306.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5OSMA P24941 1 296 298.0 AEQ:60301 Type1 Inactive None 11.127 18.074 None -109.86, 154.17 73.12, 16.86 -53.0, 141.72 257.69, 89.04 82.05, -16.7 out-out out 15.318 Saltbr-out 14.286 HRD-in -90.86, -56.33 70.3, -3.17 out-out-out SNCooo out-out ActLoopNT-out 5.659 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.75, 128.04 APE9-dihe-na -79.09, 125.46 APE8-dihe-in -62.78, 142.77 APE8-rot-out 191.22 APE67-dihe-in -64.68, -24.31 -97.3, -5.26 APE12-dist-out 20.001 APE11-dist-out 17.438 APE10-dist-out 18.797 APE9-dist-out 10.314 F80C,C177A None None XRAY 1.77 0.164 0.206 A 303 288 8 0 0 0 [[4, 286]] 1.0 5osm Homo sapiens CMGC_CDK2_HUMAN CMGC 3.4e-89 305.5 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 8UV0A P24941 2 298 298.0 XKU:301 Type1 Inactive None 11.617 18.625 None -105.02, 146.29 77.57, 16.65 -61.47, 139.79 252.4, 92.71 79.92, -11.38 out-none out 15.124 Saltbr-none 999.0 HRD-in -86.89, -59.38 84.83, -19.27 none-out-out SNCnoo out-out ActLoopNT-out 5.809 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.27 APE8-dihe-in -78.16, 130.23 APE8-rot-out 191.99 APE67-dihe-in -66.33, -22.53 -104.08, -2.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.685 None None None XRAY 1.55 0.158 0.203 A 297 279 18 0 0 10 [[4, 286]] 1.0 8uv0 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q4GA P24941 1 298 298.0 HJK:301 Type1 Inactive None 12.141 18.392 None -101.91, 150.38 79.79, 21.42 -70.25, 129.25 248.2, 99.54 94.46, -14.8 out-out out 15.566 Saltbr-out 16.264 HRD-in -91.6, -63.58 84.13, -16.52 out-out-out SNCooo out-out ActLoopNT-out 5.863 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 126.31 APE8-dihe-in -81.05, 101.62 APE8-rot-out 209.32 APE67-dihe-in -64.62, -22.35 -81.81, -4.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.325 None None None XRAY 0.98 0.191 0.211 A 306 282 16 0 0 10 [[4, 286]] 1.0 6q4g Homo sapiens CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 1PXOA P24941 1 298 298.0 CK7:500 Type1 Inactive None 11.567 18.282 None -110.76, 143.93 77.57, 24.97 -67.83, 134.31 244.11, 100.76 81.87, -11.45 out-out out 14.838 Saltbr-out 18.679 HRD-in -91.02, -53.1 76.42, -22.91 out-out-out SNCooo out-out ActLoopNT-out 5.722 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -132.43, 155.5 APE9-dihe-na -56.3, 174.32 APE8-dihe-in -103.47, 109.63 APE8-rot-out 181.49 APE67-dihe-in -54.18, -30.19 -68.46, -22.69 APE12-dist-out 20.782 APE11-dist-out 16.708 APE10-dist-out 16.669 APE9-dist-out 8.527 None None None XRAY 1.96 0.22 0.235 A 298 294 4 0 0 0 [[4, 286]] 1.0 1pxo Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2C6OA P24941 1 296 298.0 4SP:1297 Type1 Inactive None 11.114 17.988 None -115.56, 145.07 66.98, 16.14 -33.59, 128.29 259.93, 90.05 77.49, -4.49 out-out out 14.321 Saltbr-out 16.413 HRD-in -83.83, -61.4 84.51, -12.2 out-out-out SNCooo out-out ActLoopNT-out 5.874 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -72.26, 136.47 APE9-dihe-na -73.22, 134.2 APE8-dihe-in -68.16, 148.17 APE8-rot-out 36.23 APE67-dihe-in -69.25, -25.79 -97.86, -1.88 APE12-dist-out 20.031 APE11-dist-out 17.633 APE10-dist-out 18.906 APE9-dist-out 10.377 None None None XRAY 2.1 0.235 0.288 A 298 290 6 0 0 0 [[4, 286]] 1.0 2c6o Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2UZOA P24941 1 296 298.0 C62:1297 Type1 Inactive None 11.674 18.358 None -103.85, 147.99 79.37, 16.08 -56.3, 131.44 252.32, 87.14 85.48, -16.56 out-out out 15.287 Saltbr-out 14.642 HRD-in -79.48, -63.51 86.69, -26.67 out-out-out SNCooo out-out ActLoopNT-out 5.78 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -48.56, 93.61 APE9-dihe-na -64.42, -179.03 APE8-dihe-in -107.54, 95.92 APE8-rot-in 302.08 APE67-dihe-in -62.89, -28.35 -73.92, -8.85 APE12-dist-out 20.518 APE11-dist-out 17.709 APE10-dist-out 20.231 APE9-dist-out 10.715 None None None XRAY 2.3 0.215 0.291 A 298 290 6 0 0 0 [[4, 286]] 1.0 2uzo Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4D1XA P24941 3 298 298.0 ESJ:1299 Type1 Inactive None 11.491 18.242 None -113.21, 150.67 79.12, 23.97 -66.73, 134.11 245.75, 106.66 76.37, -5.48 out-out out 15.281 Saltbr-out 16.773 HRD-in -98.94, -51.15 72.95, -12.44 out-out-none SNCoon out-none ActLoopNT-out 5.901 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.04 APE8-rot-in 301.03 APE67-dihe-in -57.19, -29.17 -104.26, -4.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.196 0.238 A 298 274 22 0 0 11 [[4, 286]] 1.0 4d1x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4KD1A P24941 1 298 298.0 1QK:302 Type1 Inactive None 11.432 18.492 None -103.77, 151.97 77.61, 19.25 -58.19, 138.93 250.92, 90.26 83.97, -15.13 out-out out 16.188 Saltbr-out 15.447 HRD-in -91.06, -59.16 81.9, -15.37 out-out-out SNCooo out-out ActLoopNT-out 5.795 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.97, 126.64 APE9-dihe-na -71.76, 135.1 APE8-dihe-in -76.23, 141.92 APE8-rot-out 185.92 APE67-dihe-in -62.18, -24.46 -100.06, -1.99 APE12-dist-out 20.481 APE11-dist-out 17.738 APE10-dist-out 19.152 APE9-dist-out 10.541 None None None XRAY 1.7 0.194 0.232 A 298 298 0 0 0 0 [[4, 286]] 1.0 4kd1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5IEXA P24941 1 298 298.0 6AF:1001 Type1 Inactive None 11.106 18.344 None -105.6, 149.53 71.37, 22.65 -61.85, 135.15 236.62, 103.3 74.49, -10.58 out-out out 15.176 Saltbr-out 15.226 HRD-in -80.72, -65.3 84.99, -26.41 out-out-out SNCooo out-out ActLoopNT-out 5.802 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 111.81 APE8-dihe-in -112.57, 117.73 APE8-rot-in 277.98 APE67-dihe-in -67.92, -29.52 -99.02, -2.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.275 None None None XRAY 2.03 0.206 0.254 A 298 285 13 0 0 8 [[4, 286]] 1.0 5iex Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 5JQ5A P24941 3 298 298.0 I74:302 Type1 Inactive None 11.036 18.59 None -98.25, 154.49 69.12, 17.56 -59.33, 137.78 236.33, 97.04 85.8, -18.24 out-out out 15.293 Saltbr-out 14.692 HRD-in -87.26, -60.66 80.63, -8.99 out-out-out SNCooo out-out ActLoopNT-out 5.642 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.18, 129.81 APE9-dihe-na -70.39, 120.4 APE8-dihe-in -59.82, 139.82 APE8-rot-out 191.58 APE67-dihe-in -61.81, -24.27 -96.08, -3.96 APE12-dist-out 19.621 APE11-dist-out 17.053 APE10-dist-out 18.629 APE9-dist-out 10.149 None None None XRAY 1.94 0.184 0.241 A 298 287 9 0 0 0 [[4, 286]] 1.0 5jq5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9FR2A P24941 2 298 298.0 A1IE9:60301 Type1 Inactive None 11.37 18.225 None -103.47, 145.86 75.07, 24.54 -56.91, 141.61 253.67, 81.9 80.39, -12.16 out-out out 15.142 Saltbr-out 16.52 HRD-in -86.51, -58.7 78.24, -12.72 out-out-out SNCooo out-out ActLoopNT-out 5.738 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 138.37 APE9-dihe-na -76.24, 137.14 APE8-dihe-in -76.41, 139.85 APE8-rot-out 191.03 APE67-dihe-in -65.58, -24.55 -103.01, -3.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.146 APE9-dist-out 10.5 None None None XRAY 1.6 0.188 0.223 A 299 280 17 0 0 9 [[4, 286]] 1.0 9fr2 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3LA P24941 1 298 298.0 SCW:60501 Type1 Inactive None 11.246 18.353 None -114.1, 142.0 80.75, 16.79 -62.6, 137.12 236.35, 103.25 77.55, -11.17 out-out out 14.942 Saltbr-out 14.238 HRD-in -87.21, -57.16 83.97, -21.0 out-out-none SNCoon out-none ActLoopNT-out 5.715 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -74.73, 130.61 APE8-rot-in 281.88 APE67-dihe-in -55.71, -27.13 -104.47, -1.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None CSD177 XRAY 1.65 0.195 0.226 A 299 278 20 0 0 13 [[4, 286]] 1.0 2r3l Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 2R3RA P24941 1 298 298.0 6SC:60501 Type1 Inactive None 11.191 18.352 None -106.75, 151.66 74.43, 19.48 -59.69, 136.1 237.56, 102.06 82.51, -14.57 out-out out 15.144 Saltbr-out 15.801 HRD-in -90.58, -56.8 78.13, -12.52 out-out-out SNCooo out-out ActLoopNT-out 5.734 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -71.03, 131.85 APE9-dihe-na -78.03, 123.76 APE8-dihe-in -61.28, 139.29 APE8-rot-out 191.45 APE67-dihe-in -54.67, -29.47 -98.71, -6.16 APE12-dist-out 20.056 APE11-dist-out 17.505 APE10-dist-out 18.862 APE9-dist-out 10.181 None None None XRAY 1.47 0.188 0.211 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3r Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3IGGA P24941 1 298 298.0 EFQ:60999 Type1 Inactive None 11.372 18.317 None -105.84, 154.3 67.56, 24.15 -61.58, 141.43 251.07, 85.51 77.86, -9.43 out-out out 15.186 Saltbr-out 14.289 HRD-in -86.14, -57.51 81.55, -17.84 out-out-out SNCooo out-out ActLoopNT-out 5.712 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -82.13, 117.94 APE9-dihe-na -63.08, 134.91 APE8-dihe-in -69.96, 139.07 APE8-rot-out 188.39 APE67-dihe-in -58.19, -28.22 -106.27, -3.06 APE12-dist-out 20.463 APE11-dist-out 17.592 APE10-dist-out 19.328 APE9-dist-out 10.535 None None None XRAY 1.8 0.209 0.257 A 299 290 8 0 0 0 [[4, 286]] 1.0 3igg Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3SW4A P24941 1 298 298.0 18K:60299 Type1 Inactive None 11.515 17.956 None -115.31, 149.88 75.83, 22.3 -62.2, 138.18 254.06, 93.83 74.54, -5.64 out-out out 15.162 Saltbr-out 16.039 HRD-in -87.88, -56.91 79.23, -12.91 out-out-out SNCooo out-out ActLoopNT-out 5.897 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 117.56 APE8-dihe-in -88.23, 129.35 APE8-rot-out 189.49 APE67-dihe-in -57.9, -26.2 -102.28, -2.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.96 None None None XRAY 1.7 0.185 0.208 A 299 280 18 0 0 10 [[4, 286]] 1.0 3sw4 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKQA P24941 1 298 298.0 42K:60301 Type1 Inactive None 11.66 18.286 None -107.48, 146.45 78.71, 22.13 -63.74, 140.69 251.54, 94.03 78.47, -10.57 out-out out 15.262 Saltbr-out 16.202 HRD-in -91.18, -60.25 83.19, -19.11 out-out-out SNCooo out-out ActLoopNT-out 5.763 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 108.27 APE8-dihe-in -82.63, 126.27 APE8-rot-in 306.59 APE67-dihe-in -57.36, -27.98 -101.58, -3.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.031 None None None XRAY 1.75 0.177 0.195 A 299 283 15 0 0 9 [[4, 286]] 1.0 4fkq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 4FKRA P24941 1 298 298.0 45K:60301 Type1 Inactive None 11.549 18.516 None -111.74, 136.12 81.89, 36.01 -71.33, 130.78 250.71, 96.33 87.17, -17.31 out-out out 15.279 Saltbr-out 15.596 HRD-in -82.95, -56.41 79.68, -19.26 out-out-out SNCooo out-out ActLoopNT-out 5.992 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 124.01 APE9-dihe-na -64.18, 132.07 APE8-dihe-in -80.68, 132.68 APE8-rot-out 185.99 APE67-dihe-in -57.69, -26.44 -102.01, -3.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.781 APE9-dist-out 10.81 None None None XRAY 1.9 0.176 0.213 A 299 282 16 0 0 9 [[4, 286]] 1.0 4fkr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QQFA P24941 1 298 298.0 X07:543 Type1 Inactive None 11.451 18.483 None -112.65, 145.94 75.36, 24.29 -63.92, 139.11 248.21, 85.21 74.3, -5.06 out-out out 15.248 Saltbr-out 16.904 HRD-in -89.36, -58.1 83.53, -19.98 out-out-out SNCooo out-out ActLoopNT-out 5.733 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -60.07, 115.72 APE9-dihe-na -63.98, 132.41 APE8-dihe-in -83.8, 128.69 APE8-rot-in 304.89 APE67-dihe-in -56.5, -26.93 -103.69, -1.4 APE12-dist-out 21.167 APE11-dist-out 16.977 APE10-dist-out 19.653 APE9-dist-out 10.877 None None None XRAY 1.75 0.198 0.234 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qqf Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QQJA P24941 1 298 298.0 X11:300 Type1 Inactive None 11.296 17.14 None -118.58, 158.94 68.7, 32.83 -72.06, 149.44 252.09, 99.03 65.67, 11.61 out-out out 15.494 Saltbr-out 15.185 HRD-in -89.76, -64.75 84.08, -16.02 out-out-out SNCooo out-out ActLoopNT-out 5.723 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -51.86, 104.06 APE9-dihe-na -56.13, 139.44 APE8-dihe-in -84.97, 113.86 APE8-rot-in 306.15 APE67-dihe-in -54.47, -25.16 -98.88, -9.11 APE12-dist-out 20.988 APE11-dist-out 17.191 APE10-dist-out 20.094 APE9-dist-out 11.233 None None None XRAY 1.7 0.206 0.237 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qqj Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QTSA P24941 1 298 298.0 X46:299 Type1 Inactive None 11.782 18.126 None -114.89, 146.71 82.32, 20.63 -64.09, 138.52 252.86, 94.41 77.98, -5.5 out-out out 15.441 Saltbr-out 15.983 HRD-in -94.26, -58.23 79.96, -10.62 out-out-out SNCooo out-out ActLoopNT-out 5.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 116.66 APE9-dihe-na -67.98, 136.18 APE8-dihe-in -82.21, 129.95 APE8-rot-in 311.7 APE67-dihe-in -51.26, -29.33 -105.51, -4.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.9 APE9-dist-out 11.042 None None None XRAY 1.9 0.214 0.231 A 306 282 16 0 0 8 [[4, 286]] 1.0 3qts Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QX2A P24941 1 298 298.0 X63:300 Type1 Inactive None 11.339 18.8 None -109.52, 148.71 71.85, 23.51 -63.31, 136.62 243.05, 92.47 79.87, -9.86 out-out out 15.512 Saltbr-out 16.755 HRD-in -88.64, -58.7 83.57, -18.8 out-out-out SNCooo out-out ActLoopNT-out 5.873 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -80.45, 130.14 APE9-dihe-na -66.55, 130.29 APE8-dihe-in -81.03, 134.06 APE8-rot-in 304.55 APE67-dihe-in -57.44, -26.49 -104.17, -0.27 APE12-dist-out 20.535 APE11-dist-out 17.588 APE10-dist-out 19.312 APE9-dist-out 10.833 None None None XRAY 1.75 0.203 0.228 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qx2 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QXOA P24941 1 298 298.0 X65:668 Type1 Inactive None 11.574 18.493 None -110.12, 147.39 74.3, 21.4 -62.68, 143.03 247.92, 93.66 75.65, -10.29 out-out out 15.232 Saltbr-out 17.414 HRD-in -89.82, -59.23 81.49, -17.74 out-out-out SNCooo out-out ActLoopNT-out 5.717 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -55.35, 115.79 APE9-dihe-na -65.26, 130.77 APE8-dihe-in -78.05, 132.32 APE8-rot-out 188.29 APE67-dihe-in -54.53, -26.63 -103.75, -2.8 APE12-dist-out 21.021 APE11-dist-out 17.125 APE10-dist-out 19.546 APE9-dist-out 10.758 None None None XRAY 1.75 0.2 0.233 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qxo Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QZGA P24941 1 298 298.0 X67:471 Type1 Inactive None 11.166 17.869 None -119.24, 148.14 78.56, 29.6 -71.06, 140.3 240.31, 103.03 70.92, -7.43 out-out out 15.26 Saltbr-out 13.648 HRD-in -89.25, -59.92 83.69, -18.01 out-out-out SNCooo out-out ActLoopNT-out 5.707 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.58, 101.29 APE9-dihe-na -63.57, 138.04 APE8-dihe-in -85.08, 127.05 APE8-rot-out 179.07 APE67-dihe-in -56.84, -25.22 -100.01, -3.06 APE12-dist-out 21.43 APE11-dist-out 17.477 APE10-dist-out 20.174 APE9-dist-out 11.134 None None None XRAY 1.75 0.202 0.226 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qzg Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QZHA P24941 1 298 298.0 X69:839 Type1 Inactive None 11.47 18.511 None -109.96, 147.01 77.55, 20.64 -62.91, 134.83 250.02, 87.84 79.57, -11.69 out-out out 15.274 Saltbr-out 17.082 HRD-in -86.11, -57.23 83.13, -19.43 out-out-out SNCooo out-out ActLoopNT-out 5.717 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -79.24, 110.72 APE9-dihe-na -62.06, 126.03 APE8-dihe-in -79.43, 134.37 APE8-rot-out 78.44 APE67-dihe-in -50.01, -33.55 -102.85, -1.51 APE12-dist-out 20.944 APE11-dist-out 17.133 APE10-dist-out 19.797 APE9-dist-out 10.94 None None None XRAY 1.95 0.2 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qzh Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3QZIA P24941 1 298 298.0 X72:512 Type1 Inactive None 11.241 18.712 None -119.9, 143.48 80.19, 23.62 -68.59, 125.89 238.63, 103.46 88.77, -15.06 out-out out 15.868 Saltbr-out 16.079 HRD-in -87.48, -54.88 80.99, -18.97 out-out-out SNCooo out-out ActLoopNT-out 5.8 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -79.37, 108.03 APE9-dihe-na -59.79, 125.48 APE8-dihe-in -80.49, 121.74 APE8-rot-in 303.88 APE67-dihe-in -54.55, -27.28 -100.59, -2.07 APE12-dist-out 20.896 APE11-dist-out 17.084 APE10-dist-out 20.119 APE9-dist-out 11.169 None None None XRAY 1.75 0.207 0.236 A 306 294 4 0 0 0 [[4, 286]] 1.0 3qzi Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R1QA P24941 1 298 298.0 X75:616 Type1 Inactive None 11.368 18.457 None -115.65, 139.42 82.38, 27.94 -68.27, 134.48 251.33, 83.78 76.9, -4.37 out-out out 15.934 Saltbr-out 16.912 HRD-in -86.83, -58.27 82.98, -19.66 out-out-out SNCooo out-out ActLoopNT-out 5.72 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -65.16, 109.15 APE9-dihe-na -63.73, 128.5 APE8-dihe-in -80.12, 122.89 APE8-rot-in 299.78 APE67-dihe-in -55.47, -28.14 -102.73, -0.85 APE12-dist-out 21.35 APE11-dist-out 16.855 APE10-dist-out 20.064 APE9-dist-out 11.102 None None None XRAY 1.85 0.207 0.237 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r1q Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R1SA P24941 1 298 298.0 X73:647 Type1 Inactive None 11.563 18.462 None -112.29, 145.39 77.72, 20.9 -61.31, 140.86 249.71, 86.98 70.88, -5.99 out-out out 15.609 Saltbr-out 16.564 HRD-in -91.22, -58.91 83.77, -21.39 out-out-out SNCooo out-out ActLoopNT-out 5.777 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.87, 116.85 APE9-dihe-na -63.44, 131.28 APE8-dihe-in -83.21, 125.36 APE8-rot-in 299.44 APE67-dihe-in -52.01, -29.26 -101.45, -2.84 APE12-dist-out 21.103 APE11-dist-out 17.495 APE10-dist-out 19.908 APE9-dist-out 10.979 None None None XRAY 1.8 0.196 0.224 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r1s Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R1YA P24941 1 298 298.0 X76:488 Type1 Inactive None 11.627 18.603 None -109.35, 144.39 74.97, 25.22 -61.66, 142.02 249.79, 91.38 72.48, -3.61 out-out out 15.569 Saltbr-out 15.939 HRD-in -90.13, -57.08 83.2, -20.8 out-out-out SNCooo out-out ActLoopNT-out 5.847 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -83.02, 119.47 APE9-dihe-na -71.17, 135.18 APE8-dihe-in -73.39, 137.33 APE8-rot-out 192.27 APE67-dihe-in -53.93, -27.04 -107.87, -3.84 APE12-dist-out 20.75 APE11-dist-out 17.775 APE10-dist-out 19.752 APE9-dist-out 10.959 None None None XRAY 1.8 0.207 0.244 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r1y Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R28A P24941 1 298 298.0 XA0:782 Type1 Inactive None 11.456 18.332 None -114.85, 140.61 83.61, 19.59 -63.53, 141.74 255.66, 87.36 75.77, -16.14 out-out out 15.853 Saltbr-out 16.606 HRD-in -90.15, -56.96 81.72, -19.73 out-out-out SNCooo out-out ActLoopNT-out 5.669 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -58.89, 107.19 APE9-dihe-na -65.35, 128.85 APE8-dihe-in -78.52, 121.12 APE8-rot-in 294.31 APE67-dihe-in -52.84, -26.8 -102.58, -3.56 APE12-dist-out 21.242 APE11-dist-out 17.369 APE10-dist-out 20.26 APE9-dist-out 11.224 None None None XRAY 1.75 0.204 0.256 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r28 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R6XA P24941 1 298 298.0 X84:778 Type1 Inactive None 11.616 18.525 None -112.76, 145.27 77.03, 24.29 -64.96, 138.51 251.1, 86.55 78.86, -11.42 out-out out 15.599 Saltbr-out 16.687 HRD-in -91.18, -56.87 81.41, -17.78 out-out-out SNCooo out-out ActLoopNT-out 5.803 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -77.89, 119.44 APE9-dihe-na -60.25, 129.79 APE8-dihe-in -81.9, 126.65 APE8-rot-in 293.24 APE67-dihe-in -53.85, -27.75 -103.49, -2.87 APE12-dist-out 20.971 APE11-dist-out 17.332 APE10-dist-out 19.861 APE9-dist-out 11.004 None None None XRAY 1.75 0.198 0.235 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r6x Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R71A P24941 1 298 298.0 X86:800 Type1 Inactive None 11.577 18.758 None -105.68, 148.59 72.24, 22.66 -59.47, 139.95 248.96, 87.94 80.85, -15.21 out-out out 15.516 Saltbr-out 16.195 HRD-in -93.08, -56.95 82.29, -19.56 out-out-out SNCooo out-out ActLoopNT-out 5.744 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.99, 123.25 APE9-dihe-na -70.56, 131.23 APE8-dihe-in -64.96, 140.3 APE8-rot-out 196.43 APE67-dihe-in -57.0, -27.71 -104.59, -0.92 APE12-dist-out 20.602 APE11-dist-out 17.729 APE10-dist-out 19.119 APE9-dist-out 10.651 None None None XRAY 1.75 0.209 0.237 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r71 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R73A P24941 1 298 298.0 X87:920 Type1 Inactive None 11.655 18.593 None -113.72, 142.29 80.42, 22.84 -64.05, 138.77 253.65, 86.24 78.07, -8.79 out-out out 15.59 Saltbr-out 15.546 HRD-in -91.99, -58.09 83.71, -19.3 out-out-out SNCooo out-out ActLoopNT-out 5.832 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.42, 122.96 APE9-dihe-na -72.13, 133.83 APE8-dihe-in -82.06, 127.89 APE8-rot-in 303.64 APE67-dihe-in -52.93, -28.63 -103.22, -2.15 APE12-dist-out 20.907 APE11-dist-out 17.183 APE10-dist-out 19.838 APE9-dist-out 11.009 None None None XRAY 1.7 0.2 0.221 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r73 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R7EA P24941 1 298 298.0 X88:919 Type1 Inactive None 11.325 18.478 None -107.54, 147.9 71.92, 27.82 -65.12, 136.21 243.68, 100.5 76.51, -6.15 out-out out 15.377 Saltbr-out 17.436 HRD-in -86.38, -57.25 81.31, -18.98 out-out-out SNCooo out-out ActLoopNT-out 5.727 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -57.64, 107.43 APE9-dihe-na -74.1, 129.96 APE8-dihe-in -74.77, 142.87 APE8-rot-out 90.22 APE67-dihe-in -54.91, -29.86 -109.18, 1.75 APE12-dist-out 21.034 APE11-dist-out 16.951 APE10-dist-out 19.596 APE9-dist-out 10.87 None None None XRAY 1.9 0.199 0.237 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r7e Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R7IA P24941 1 298 298.0 X9I:505 Type1 Inactive None 11.369 18.564 None -113.0, 148.3 76.34, 21.13 -64.54, 139.22 245.45, 99.94 76.8, -11.16 out-out out 15.537 Saltbr-out 15.05 HRD-in -88.86, -59.71 85.14, -20.04 out-out-out SNCooo out-out ActLoopNT-out 5.731 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 118.01 APE9-dihe-na -55.02, 130.86 APE8-dihe-in -86.42, 128.86 APE8-rot-out 186.41 APE67-dihe-in -52.47, -29.57 -102.58, -3.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.743 APE9-dist-out 10.967 None None None XRAY 1.85 0.195 0.223 A 306 282 16 0 0 8 [[4, 286]] 1.0 3r7i Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R7UA P24941 1 298 298.0 X96:523 Type1 Inactive None 11.369 18.665 None -111.2, 145.35 75.59, 25.93 -64.52, 137.61 245.01, 94.0 77.96, -11.73 out-out out 15.524 Saltbr-out 14.374 HRD-in -90.67, -56.58 81.34, -16.99 out-out-out SNCooo out-out ActLoopNT-out 5.758 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 130.63 APE9-dihe-na -60.27, 126.26 APE8-dihe-in -81.26, 130.03 APE8-rot-out 184.92 APE67-dihe-in -53.8, -28.22 -102.48, -2.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.57 APE9-dist-out 10.786 None None None XRAY 1.75 0.198 0.232 A 306 282 16 0 0 8 [[4, 286]] 1.0 3r7u Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R7VA P24941 1 298 298.0 Z02:490 Type1 Inactive None 11.363 18.417 None -110.13, 148.48 72.96, 23.08 -62.99, 137.41 242.23, 98.62 77.48, -10.39 out-out out 15.292 Saltbr-out 16.932 HRD-in -89.74, -53.81 81.3, -23.16 out-out-out SNCooo out-out ActLoopNT-out 5.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.42, 108.48 APE9-dihe-na -68.89, 131.48 APE8-dihe-in -68.83, 138.12 APE8-rot-out 192.5 APE67-dihe-in -55.66, -29.18 -106.11, -4.25 APE12-dist-out 20.906 APE11-dist-out 16.882 APE10-dist-out 19.418 APE9-dist-out 10.836 None None None XRAY 1.95 0.188 0.228 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r7v Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R7YA P24941 1 298 298.0 Z04:484 Type1 Inactive None 11.407 18.602 None -106.05, 149.21 72.28, 22.75 -60.56, 141.54 242.85, 100.98 77.08, -15.41 out-out out 15.509 Saltbr-out 17.635 HRD-in -92.8, -56.53 83.12, -18.85 out-out-out SNCooo out-out ActLoopNT-out 5.88 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.59, 125.71 APE9-dihe-na -71.8, 133.79 APE8-dihe-in -65.57, 140.02 APE8-rot-out 191.94 APE67-dihe-in -54.29, -31.44 -105.45, -2.12 APE12-dist-out 20.463 APE11-dist-out 17.742 APE10-dist-out 19.047 APE9-dist-out 10.621 None None None XRAY 1.9 0.191 0.218 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r7y Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R83A P24941 1 298 298.0 Z14:589 Type1 Inactive None 11.533 18.764 None -108.4, 152.29 71.89, 22.89 -60.12, 136.31 246.86, 97.3 84.46, -13.15 out-out out 15.921 Saltbr-out 16.794 HRD-in -96.6, -56.11 81.89, -15.1 out-out-out SNCooo out-out ActLoopNT-out 6.071 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -74.86, 129.6 APE9-dihe-na -76.77, 128.27 APE8-dihe-in -63.71, 142.82 APE8-rot-out 188.48 APE67-dihe-in -52.24, -30.72 -105.79, -5.55 APE12-dist-out 20.357 APE11-dist-out 17.854 APE10-dist-out 19.066 APE9-dist-out 10.74 None None None XRAY 1.75 0.198 0.23 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r83 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R8UA P24941 1 298 298.0 Z31:465 Type1 Inactive None 11.635 18.342 None -107.57, 143.44 81.21, 21.99 -62.01, 141.86 250.02, 87.35 78.29, -11.82 out-out out 15.359 Saltbr-out 16.228 HRD-in -90.94, -56.25 78.46, -9.5 out-out-out SNCooo out-out ActLoopNT-out 5.65 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -48.32, 111.28 APE9-dihe-na -78.48, 130.39 APE8-dihe-in -71.58, 132.49 APE8-rot-out 185.17 APE67-dihe-in -52.89, -31.15 -106.36, -2.37 APE12-dist-out 21.012 APE11-dist-out 17.405 APE10-dist-out 20.021 APE9-dist-out 10.955 None None None XRAY 2.0 0.2 0.236 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r8u Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R8VA P24941 1 298 298.0 Z62:473 Type1 Inactive None 11.836 18.479 None -108.05, 152.25 77.1, 17.76 -60.61, 141.17 250.98, 94.27 79.61, -8.79 out-out out 15.78 Saltbr-out 17.037 HRD-in -95.62, -59.61 84.51, -14.19 out-out-out SNCooo out-out ActLoopNT-out 5.874 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -151.05, 140.69 APE9-dihe-na -102.28, 128.28 APE8-dihe-in -73.69, 133.66 APE8-rot-out 186.34 APE67-dihe-in -50.08, -28.19 -107.76, -6.89 APE12-dist-out 22.045 APE11-dist-out 18.616 APE10-dist-out 19.832 APE9-dist-out 11.207 None None None XRAY 1.9 0.192 0.229 A 306 294 4 0 0 0 [[4, 286]] 1.0 3r8v Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3R9NA P24941 1 298 298.0 Z68:529 Type1 Inactive None 11.778 18.357 None -111.04, 151.86 80.88, 16.04 -60.64, 141.85 253.93, 94.35 77.93, -10.08 out-out out 15.601 Saltbr-out 15.958 HRD-in -96.05, -60.18 85.28, -15.24 out-out-out SNCooo out-out ActLoopNT-out 5.825 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 129.61 APE9-dihe-na -90.33, 137.03 APE8-dihe-in -79.79, 134.05 APE8-rot-out 185.52 APE67-dihe-in -53.47, -28.97 -107.38, -1.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.812 APE9-dist-out 11.165 None None None XRAY 1.75 0.189 0.21 A 306 282 16 0 0 8 [[4, 286]] 1.0 3r9n Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RAHA P24941 1 298 298.0 O1Z:516 Type1 Inactive None 11.796 18.355 None -110.29, 152.99 77.93, 18.04 -61.85, 142.5 252.0, 97.4 76.6, -9.77 out-out out 15.596 Saltbr-out 16.001 HRD-in -93.29, -59.77 84.17, -13.21 out-out-out SNCooo out-out ActLoopNT-out 5.763 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 126.0 APE9-dihe-na -86.71, 138.48 APE8-dihe-in -81.09, 133.18 APE8-rot-out 181.97 APE67-dihe-in -50.91, -30.54 -106.41, -3.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.851 APE9-dist-out 11.072 None None None XRAY 1.75 0.197 0.224 A 306 282 16 0 0 8 [[4, 286]] 1.0 3rah Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RAIA P24941 1 298 298.0 X85:923 Type1 Inactive None 11.607 18.533 None -112.0, 145.89 74.76, 25.65 -65.32, 141.74 252.05, 86.7 75.22, -8.21 out-out out 15.233 Saltbr-out 16.738 HRD-in -91.9, -56.22 80.55, -18.43 out-out-out SNCooo out-out ActLoopNT-out 5.752 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -49.77, 110.97 APE9-dihe-na -68.15, 127.08 APE8-dihe-in -76.82, 124.51 APE8-rot-in 307.79 APE67-dihe-in -54.47, -28.12 -101.96, -2.13 APE12-dist-out 20.941 APE11-dist-out 17.332 APE10-dist-out 20.017 APE9-dist-out 11.059 None None None XRAY 1.7 0.206 0.246 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rai Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RM7A P24941 1 298 298.0 19Z:654 Type1 Inactive None 11.446 18.412 None -110.62, 146.92 75.2, 22.58 -62.06, 138.87 244.23, 100.43 74.51, -5.06 out-out out 15.235 Saltbr-out 16.963 HRD-in -88.0, -57.21 81.55, -20.72 out-out-out SNCooo out-out ActLoopNT-out 5.742 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.65, 115.14 APE9-dihe-na -67.67, 126.3 APE8-dihe-in -75.61, 130.68 APE8-rot-in 296.31 APE67-dihe-in -54.47, -28.79 -106.07, -1.05 APE12-dist-out 21.303 APE11-dist-out 16.937 APE10-dist-out 19.596 APE9-dist-out 10.832 None None None XRAY 1.85 0.2 0.239 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rm7 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3ROYA P24941 1 298 298.0 22Z:781 Type1 Inactive None 11.46 18.393 None -113.43, 143.96 78.34, 23.65 -63.28, 140.65 252.96, 88.59 73.47, -8.3 out-out out 15.717 Saltbr-out 12.931 HRD-in -88.52, -59.01 82.46, -18.91 out-out-out SNCooo out-out ActLoopNT-out 5.728 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -70.01, 109.19 APE9-dihe-na -59.45, 127.78 APE8-dihe-in -82.4, 126.58 APE8-rot-in 303.09 APE67-dihe-in -54.76, -26.31 -102.63, -0.93 APE12-dist-out 20.68 APE11-dist-out 17.278 APE10-dist-out 20.005 APE9-dist-out 11.083 None None None XRAY 1.75 0.203 0.239 A 306 294 4 0 0 0 [[4, 286]] 1.0 3roy Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RPOA P24941 1 298 298.0 24Z:778 Type1 Inactive None 11.47 18.867 None -105.85, 149.39 71.39, 21.76 -61.36, 139.85 242.5, 91.57 76.43, -10.77 out-out out 15.707 Saltbr-out 16.039 HRD-in -92.26, -58.75 84.44, -19.22 out-out-out SNCooo out-out ActLoopNT-out 5.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.98, 126.83 APE9-dihe-na -72.5, 130.98 APE8-dihe-in -72.57, 140.79 APE8-rot-out 78.9 APE67-dihe-in -55.8, -27.77 -107.74, -1.05 APE12-dist-out 20.851 APE11-dist-out 17.697 APE10-dist-out 19.481 APE9-dist-out 10.877 None None None XRAY 1.75 0.198 0.226 A 306 294 4 0 0 0 [[4, 286]] 1.0 3rpo Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3RPRA P24941 1 298 298.0 25Z:529 Type1 Inactive None 11.844 18.444 None -111.94, 154.75 77.55, 17.41 -61.57, 142.53 250.82, 96.24 78.31, -12.31 out-out out 15.56 Saltbr-out 15.958 HRD-in -93.07, -60.25 84.58, -14.39 out-out-out SNCooo out-out ActLoopNT-out 5.748 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 136.43 APE9-dihe-na -85.09, 131.13 APE8-dihe-in -82.88, 126.09 APE8-rot-in 309.34 APE67-dihe-in -54.36, -26.86 -106.55, -1.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.993 APE9-dist-out 11.312 None None None XRAY 1.75 0.189 0.217 A 306 282 16 0 0 8 [[4, 286]] 1.0 3rpr Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3S00A P24941 1 298 298.0 Z60:461 Type1 Inactive None 11.566 18.357 None -113.01, 158.12 73.15, 19.07 -62.76, 138.03 244.84, 103.73 75.94, -1.66 out-out out 15.467 Saltbr-out 16.207 HRD-in -93.79, -61.48 83.11, -12.57 out-out-out SNCooo out-out ActLoopNT-out 5.809 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -66.14, 127.34 APE9-dihe-na -83.29, 139.02 APE8-dihe-in -84.78, 133.09 APE8-rot-out 186.6 APE67-dihe-in -50.63, -29.06 -104.24, -5.63 APE12-dist-out 21.225 APE11-dist-out 18.093 APE10-dist-out 19.946 APE9-dist-out 11.217 None None None XRAY 1.8 0.216 0.251 A 306 294 4 0 0 0 [[4, 286]] 1.0 3s00 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6GUKA P24941 1 298 298.0 FC8:301 Type1 Inactive None 11.495 18.296 None -105.76, 142.13 85.41, 11.26 -53.22, 139.96 258.83, 85.48 82.71, -9.99 out-out out 16.208 Saltbr-out 15.81 HRD-in -84.25, -64.23 86.29, -13.89 out-out-out SNCooo out-out ActLoopNT-out 5.784 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 126.62 APE8-dihe-in -72.63, 127.56 APE8-rot-out 192.14 APE67-dihe-in -62.77, -24.98 -100.92, -3.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.213 None None None XRAY 1.3 0.206 0.232 A 306 278 20 0 0 10 [[4, 286]] 1.0 6guk Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q48A P24941 1 296 298.0 HHQ:302 Type1 Inactive None 11.735 18.081 None -106.16, 153.92 82.02, 17.32 -55.23, 142.63 259.92, 89.4 83.11, -15.88 out-out out 15.641 Saltbr-out 17.373 HRD-in -92.3, -63.2 83.34, -15.4 out-out-out SNCooo out-out ActLoopNT-out 5.942 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -92.12, 150.91 APE9-dihe-na -70.17, 141.74 APE8-dihe-in -85.56, 124.19 APE8-rot-in 313.51 APE67-dihe-in -62.02, -25.18 -103.39, -3.65 APE12-dist-none 999.0 APE11-dist-out 19.346 APE10-dist-out 20.001 APE9-dist-out 11.313 None None None XRAY 1.03 0.189 0.214 A 306 280 16 0 0 8 [[4, 286]] 1.0 6q48 Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q4AA P24941 1 298 298.0 HGW:301 Type1 Inactive None 11.306 18.484 None -99.64, 151.34 71.13, 19.02 -56.46, 143.53 245.43, 97.69 75.11, -5.52 out-out out 15.394 Saltbr-out 16.363 HRD-in -87.49, -64.78 82.76, -10.85 out-out-out SNCooo out-out ActLoopNT-out 5.872 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -54.84, 127.77 APE9-dihe-na -73.06, 129.93 APE8-dihe-in -62.58, 141.11 APE8-rot-out 189.02 APE67-dihe-in -63.75, -25.74 -99.36, -2.17 APE12-dist-out 21.026 APE11-dist-out 17.754 APE10-dist-out 19.364 APE9-dist-out 10.597 None None None XRAY 1.13 0.184 0.22 A 306 292 6 0 0 0 [[4, 286]] 1.0 6q4a Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q4BA P24941 1 298 298.0 HHN:301 Type1 Inactive None 11.287 18.407 None -101.91, 152.75 72.94, 19.11 -57.76, 142.71 248.24, 88.8 81.19, -13.46 out-out out 15.314 Saltbr-out 15.984 HRD-in -89.83, -61.58 81.31, -13.01 out-out-out SNCooo out-out ActLoopNT-out 5.665 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.3, 127.49 APE9-dihe-na -72.88, 129.85 APE8-dihe-in -66.95, 144.25 APE8-rot-out 190.39 APE67-dihe-in -63.63, -25.03 -98.0, -6.38 APE12-dist-out 21.153 APE11-dist-out 18.241 APE10-dist-out 19.458 APE9-dist-out 10.729 None None None XRAY 1.12 0.174 0.203 A 306 291 7 0 0 0 [[4, 286]] 1.0 6q4b Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q4EA P24941 1 298 298.0 HH5:60303 Type1 Inactive None 11.63 18.238 None -103.98, 152.64 76.57, 26.47 -63.26, 142.69 253.01, 93.18 81.41, -12.31 out-out out 15.69 Saltbr-out 17.382 HRD-in -89.59, -63.45 82.73, -15.6 out-out-out SNCooo out-out ActLoopNT-out 5.872 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -85.93, 124.92 APE9-dihe-na -69.0, 134.19 APE8-dihe-in -81.8, 128.13 APE8-rot-in 317.48 APE67-dihe-in -63.28, -22.25 -98.83, -7.08 APE12-dist-none 999.0 APE11-dist-out 19.146 APE10-dist-out 19.915 APE9-dist-out 11.09 None None None XRAY 1.06 0.18 0.205 A 306 283 15 0 0 8 [[4, 286]] 1.0 6q4e Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q4FA P24941 1 298 298.0 26D:60301 Type1 Inactive None 11.149 18.509 None -99.9, 150.98 69.26, 23.21 -68.2, 128.13 225.13, 109.26 95.17, -11.31 out-out out 15.504 Saltbr-out 17.136 HRD-in -92.63, -57.87 83.01, -20.55 out-out-out SNCooo out-out ActLoopNT-out 5.854 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.92, 124.88 APE9-dihe-na -71.16, 129.7 APE8-dihe-in -66.86, 140.78 APE8-rot-out 189.11 APE67-dihe-in -63.65, -26.7 -98.16, -5.09 APE12-dist-out 20.244 APE11-dist-out 17.335 APE10-dist-out 18.865 APE9-dist-out 10.511 None None OCS177 XRAY 1.21 0.169 0.205 A 306 291 7 0 0 0 [[4, 286]] 1.0 6q4f Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q4JA P24941 1 298 298.0 HHB:60303 Type1 Inactive None 11.747 18.149 None -105.7, 151.51 81.04, 19.19 -56.11, 142.38 259.55, 88.13 81.71, -13.13 out-out out 15.722 Saltbr-out 16.957 HRD-in -91.04, -65.92 84.39, -14.99 out-out-out SNCooo out-out ActLoopNT-out 5.918 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -75.05, 123.68 APE9-dihe-na -83.72, 133.18 APE8-dihe-in -77.62, 129.92 APE8-rot-in 308.78 APE67-dihe-in -62.98, -23.89 -102.14, -4.26 APE12-dist-out 18.992 APE11-dist-out 17.065 APE10-dist-out 19.845 APE9-dist-out 11.16 None None None XRAY 1.05 0.167 0.186 A 306 288 10 0 0 2 [[4, 286]] 1.0 6q4j Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 7ZPCA P24941 1 298 298.0 JLC:301 Type1 Inactive None 11.284 18.395 None -103.05, 151.04 70.8, 21.9 -57.66, 139.66 245.5, 92.68 84.19, -12.26 out-out out 15.619 Saltbr-out 17.181 HRD-in -90.47, -66.21 83.27, -5.36 out-out-out SNCooo out-out ActLoopNT-out 5.828 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.11, 126.85 APE9-dihe-na -73.86, 129.02 APE8-dihe-in -68.16, 141.96 APE8-rot-out 190.37 APE67-dihe-in -61.55, -25.3 -100.47, -4.17 APE12-dist-out 21.133 APE11-dist-out 18.201 APE10-dist-out 19.373 APE9-dist-out 10.555 None None None XRAY 1.4 0.202 0.221 A 306 291 7 0 0 0 [[4, 286]] 1.0 7zpc Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9GNOA P24941 1 298 298.0 A1INI:301 Type1 Inactive None 11.354 18.311 None -111.15, 148.64 78.64, 18.41 -59.09, 139.63 256.45, 91.79 82.04, -13.45 out-out out 15.409 Saltbr-out 16.679 HRD-in -87.97, -59.85 82.33, -16.25 out-out-out SNCooo out-out ActLoopNT-out 5.939 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 129.23 APE9-dihe-na -76.58, 128.77 APE8-dihe-in -74.77, 135.66 APE8-rot-out 189.97 APE67-dihe-in -61.46, -24.46 -99.9, -1.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.15 APE9-dist-out 10.796 None None None XRAY 1.16 0.204 0.225 A 306 277 21 0 0 10 [[4, 286]] 1.0 9gno Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q3BA P24941 1 298 298.0 PYZ:301,PYZ:302 Type1,Type1 Inactive None 11.695 18.369 None -99.21, 147.26 85.4, 20.21 -55.37, 141.31 259.87, 90.07 83.45, -13.95 out-out out 15.722 Saltbr-out 16.482 HRD-in -91.88, -62.73 83.2, -16.39 out-out-out SNCooo out-out ActLoopNT-out 5.862 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 105.63 APE9-dihe-na -77.44, 137.9 APE8-dihe-in -71.09, 136.23 APE8-rot-out 190.04 APE67-dihe-in -62.88, -22.27 -97.15, -7.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.81 APE9-dist-out 10.926 None None None XRAY 1.11 0.212 0.249 A 306 283 15 0 0 8 [[4, 286]] 1.0 6q3b Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 6Q3CA P24941 2 298 298.0 BYZ:301,BYZ:302 Type1,Type1 Inactive None 11.011 18.345 None -105.89, 149.7 74.24, 21.25 -56.86, 140.5 243.36, 93.53 83.71, -11.42 out-out out 15.464 Saltbr-out 16.517 HRD-in -92.99, -59.73 78.01, -9.32 out-out-out SNCooo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.04, 126.39 APE9-dihe-na -72.41, 128.47 APE8-dihe-in -64.49, 140.67 APE8-rot-out 189.27 APE67-dihe-in -62.38, -27.04 -100.06, -1.63 APE12-dist-out 20.246 APE11-dist-out 17.53 APE10-dist-out 18.863 APE9-dist-out 10.38 None None OCS177 XRAY 1.29 0.142 0.178 A 306 289 8 0 0 0 [[4, 286]] 1.0 6q3c Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3EIDC P24941 1 296 298.0 No_ligand No_ligand None DFGin 6.489 15.863 BLAminus -134.04, 176.12 56.38, 81.46 -98.21, 27.52 280.67, 71.27 -62.82, -36.83 in-in in 8.955 Saltbr-in 2.698 HRD-in -81.37, -49.78 74.95, -21.85 in-in-none SNCiin in-none ActLoopNT-in 2.833 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_inni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 125.0 APE8-dihe-in -62.75, 132.6 APE8-rot-in 299.6 APE67-dihe-in -57.24, -38.19 -61.24, -41.52 APE12-dist-in 13.922 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.564 None None None XRAY 3.15 0.207 0.261 C 298 290 6 0 0 2 [[4, 286]] 1.0 3eid Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 3EIDA P24941 1 297 298.0 PO5:299 Type1 None DFGin 6.59 15.583 BLAminus -132.85, -177.52 48.93, 84.46 -100.76, 28.79 277.88, 66.9 -65.0, -34.5 in-in in 8.664 Saltbr-in 2.841 HRD-in -79.0, -48.15 75.16, -17.88 in-in-none SNCiin in-none ActLoopNT-in 2.891 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -96.83 APE9-dihe-na -46.53, 147.39 APE8-dihe-in -64.52, 140.51 APE8-rot-in 326.76 APE67-dihe-in -65.78, -38.63 -57.31, -43.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.918 APE9-dist-in 4.475 None None None XRAY 3.15 0.207 0.261 A 298 292 5 0 0 2 [[4, 286]] 1.0 3eid Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CDK2_HUMAN 9GOPA P24941 1 298 298.0 A1IOI:60301 Type1 None DFGin 7.359 15.214 BLAminus -127.3, 173.02 54.03, 84.28 -99.69, 32.25 282.59, 81.45 -70.11, -42.44 in-in in 8.723 Saltbr-in 2.939 HRD-in -74.49, -42.35 70.77, -14.6 in-in-none SNCiin in-none ActLoopNT-in 2.913 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.86 APE8-dihe-in -65.97, 133.38 APE8-rot-in 277.05 APE67-dihe-in -57.91, -32.79 -19.7, -52.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.633 None None None XRAY 2.158 0.232 0.271 A 298 291 7 0 0 7 [[4, 286]] 1.0 9gop Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

CMGC_CDK2 (Cyclin-dependent kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name