ROCK1 (Rho-associated protein kinase 1)

Group: AGC
Uniprot: ROCK1_HUMAN
Domain boundary: 76 - 338


Total number of chains: 76
Spatial Dihedral Chains Representative
DFGin BLAminus 46 AF-Q13464-K1A
DFGin ABAminus 22 5WNFA
DFGin BLBminus 1 7S26C
DFGin None 1 3TWJC
DFGinter None 2 3TWJB
DFGout None 3 7S25B
None None 1 7S25D
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
3NDMA 3.3 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 6 - 402 None None 0
3NCZA 3.0 Inactive DFGin ABAminus in-in in-in 3NC Type1 6 - 402 None None 0
3NCZB 3.0 Inactive DFGin ABAminus in-in in-in 3NC Type1 6 - 402 None None 2
3NCZC 3.0 Inactive DFGin ABAminus in-in in-in 3NC Type1 6 - 404 None None 1
3NCZD 3.0 Inactive DFGin ABAminus in-in in-in 3NC Type1 6 - 402 None None 0
3NDMB 3.3 Inactive DFGin ABAminus in-in in-in 3ND Type1 7 - 402 None None 0
3NDMC 3.3 Inactive DFGin ABAminus in-in in-none 3ND Type1 6 - 402 None None 5
3NDMD 3.3 Inactive DFGin ABAminus in-in in-in 3ND Type1 7 - 402 None None 0
5WNFA 2.45 Inactive DFGin ABAminus in-in in-in B4V Type1 7 - 401 None None 0
5WNFB 2.45 Inactive DFGin ABAminus in-in in-none B4V Type1 6 - 402 None None 7
5WNFC 2.45 Inactive DFGin ABAminus in-in in-in B4V Type1 6 - 402 None None 0
5WNFD 2.45 Inactive DFGin ABAminus in-in in-in B4V Type1 7 - 402 None None 0
5WNGA 2.9 Inactive DFGin ABAminus in-in in-in B4Y Type1 7 - 401 None None 0
5WNGB 2.9 Inactive DFGin ABAminus in-in in-none B4Y Type1 6 - 402 None None 7
5WNGC 2.9 Inactive DFGin ABAminus in-in in-in B4Y Type1 6 - 402 None None 0
5WNGD 2.9 Inactive DFGin ABAminus in-in in-in B4Y Type1 7 - 402 None None 0
5WNHA 3.1 Inactive DFGin ABAminus in-in in-in B5G Type1 6 - 401 None None 0
5WNHB 3.1 Inactive DFGin ABAminus in-in in-none B5G Type1 6 - 402 None None 7
5WNHC 3.1 Inactive DFGin ABAminus in-in in-in B5G Type1 6 - 402 None None 0
5WNHD 3.1 Inactive DFGin ABAminus in-in in-in B5G Type1 6 - 402 None None 0
6E9WA 2.96 Inactive DFGin ABAminus in-in in-in J0P Type1 9 - 404 None None 0
6E9WB 2.96 Inactive DFGin ABAminus in-in in-out J0P Type1 7 - 401 None None 0
AF-Q13464-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 68 - 346 None None 0
7S26D 2.744 None DFGin BLAminus in-in in-none No_ligand No_ligand 6 - 399 None None 23
7S26A 2.744 None DFGin BLAminus in-in in-none 86K Type1 6 - 401 None None 6
7S26B 2.744 None DFGin BLAminus in-in none-none 86K Type1 6 - 402 None None 19
2V55A 3.705 Active DFGin BLAminus in-in in-in ANP Type1 6 - 404 None None 0
2V55C 3.705 Active DFGin BLAminus in-in in-in ANP Type1 6 - 404 None None 0
3TV7A 2.75 Inactive DFGin BLAminus in-in in-out 07Q Type1 9 - 402 None None 0
3TV7B 2.75 Inactive DFGin BLAminus in-in in-out 07Q Type1 6 - 402 None None 0
3TV7C 2.75 Inactive DFGin BLAminus in-in in-out 07Q Type1 9 - 402 None None 0
3TV7D 2.75 Inactive DFGin BLAminus in-in in-out 07Q Type1 6 - 402 None None 0
3V8SA 2.286 Active DFGin BLAminus in-in in-in 0HD Type1 8 - 402 None None 0
3V8SB 2.286 Inactive DFGin BLAminus in-in in-out 0HD Type1 6 - 402 None None 0
3V8SC 2.286 Active DFGin BLAminus in-in in-in 0HD Type1 8 - 402 None None 0
3V8SD 2.286 Inactive DFGin BLAminus in-in in-out 0HD Type1 6 - 402 None None 0
4W7PA 2.8 Active DFGin BLAminus in-in in-in 3J7 Type1 6 - 405 None None 0
4W7PB 2.8 Active DFGin BLAminus in-in in-in 3J7 Type1 6 - 401 None None 0
4W7PC 2.8 Active DFGin BLAminus in-in in-in 3J7 Type1 6 - 401 None None 0
4W7PD 2.8 Active DFGin BLAminus in-in in-in 3J7 Type1 6 - 403 None None 0
7JOUA 3.318 Active DFGin BLAminus in-in in-in VFS Type1 9 - 402 None None 0
2ESMA 3.2 Active DFGin BLAminus in-in in-in M77 Type1 6 - 405 None None 0
2ESMB 3.2 Inactive DFGin BLAminus in-in in-out M77 Type1 6 - 402 None None 0
2ETKA 2.96 Active DFGin BLAminus in-in in-in HFS Type1 6 - 405 None None 0
2ETKB 2.96 Inactive DFGin BLAminus in-in in-out HFS Type1 6 - 402 None None 0
2ETRA 2.6 Active DFGin BLAminus in-in in-in Y27 Type1 6 - 405 None None 0
2ETRB 2.6 Inactive DFGin BLAminus in-in in-out Y27 Type1 6 - 402 None None 0
3D9VA 3.3 Active DFGin BLAminus in-in in-in H52 Type1 6 - 405 None None 0
3D9VB 3.3 Inactive DFGin BLAminus in-in in-out H52 Type1 6 - 402 None None 0
4YVCA 3.2 Active DFGin BLAminus in-in in-in 4KH Type1 6 - 405 None None 0
4YVCB 3.2 Inactive DFGin BLAminus in-in in-out 4KH Type1 6 - 402 None None 0
4YVEA 3.4 Active DFGin BLAminus in-in in-in 4KK Type1 6 - 405 None None 0
4YVEB 3.4 Inactive DFGin BLAminus in-in in-out 4KK Type1 6 - 402 None None 0
5BMLA 2.95 Active DFGin BLAminus in-in in-in 4TW Type1 6 - 405 None None 0
5BMLB 2.95 Inactive DFGin BLAminus in-in in-out 4TW Type1 6 - 402 None None 0
5KKSA 3.3 Active DFGin BLAminus in-in in-in 6U1 Type1 6 - 405 None None 0
5KKTA 2.8 Active DFGin BLAminus in-in in-in 6U2 Type1 6 - 405 None None 0
5UZJA 3.3 Active DFGin BLAminus in-in in-in 8UV Type1 6 - 405 None None 0
5UZJB 3.3 Inactive DFGin BLAminus in-in in-out 8UV Type1 6 - 402 None None 0
3TWJA 2.9 Inactive DFGin BLAminus in-in in-out 07R Type1.5_Back 7 - 402 None None 0
5HVUA 2.8 Active DFGin BLAminus in-in in-in 65R Type1.5_Front 6 - 405 None None 0
5HVUB 2.8 None DFGin BLAminus in-in in-none 65R Type1.5_Front 6 - 402 None None 4
5KKSB 3.3 Inactive DFGin BLAminus in-in in-out 6U1 Type1.5_Front 6 - 402 None None 0
5KKTB 2.8 Inactive DFGin BLAminus in-in in-out 6U2 Type1.5_Front 6 - 402 None None 0
5WNEA 2.6 Active DFGin BLAminus in-in in-in B4J Type1.5_Front 14 - 400 None None 0
5WNEB 2.6 None DFGin BLAminus in-in in-none B4J Type1.5_Front 6 - 402 None None 9
5WNEC 2.6 Active DFGin BLAminus in-in in-in B4J Type1.5_Front 6 - 402 None None 0
5WNED 2.6 Active DFGin BLAminus in-in in-in B4J Type1.5_Front 7 - 402 None None 0
7S26C 2.744 Inactive DFGin BLBminus in-in none-none 86K Type1 8 - 402 None None 18
3TWJC 2.9 Inactive DFGin None in-out out-out 07R Type1 7 - 402 None None 0
3TWJB 2.9 Inactive DFGinter None in-in out-in No_ligand No_ligand 8 - 402 None None 0
3TWJD 2.9 Inactive DFGinter None in-in out-in No_ligand No_ligand 8 - 402 None None 0
7S25A 2.337 Inactive DFGout None in-in none-out 86G Type1 7 - 401 None None 17
7S25B 2.337 Inactive DFGout None in-in none-out 86G Type1 8 - 402 None None 12
7S25C 2.337 Inactive DFGout None in-in none-none 86G Type1 13 - 402 None None 18
7S25D 2.337 Inactive None None in-in none-none No_ligand No_ligand 9 - 401 None None 29

ROCK1 (Rho-associated protein kinase 1)

Group: AGC
Total number of chains: 76
Spatial Dihedral Chains Representative
DFGin BLAminus 46 AF-Q13464-K1A
DFGin ABAminus 22 5WNFA
DFGin BLBminus 1 7S26C
DFGin None 1 3TWJC
DFGinter None 2 3TWJB
DFGout None 3 7S25B
None None 1 7S25D
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens ROCK1_HUMAN 3NDMA 3.3 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3NCZA 3.0 Inactive DFGin ABAminus in-in in-in 3NC Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3NCZB 3.0 Inactive DFGin ABAminus in-in in-in 3NC Type1 6 - 402 None None 2
Homo sapiens ROCK1_HUMAN 3NCZC 3.0 Inactive DFGin ABAminus in-in in-in 3NC Type1 6 - 404 None None 1
Homo sapiens ROCK1_HUMAN 3NCZD 3.0 Inactive DFGin ABAminus in-in in-in 3NC Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3NDMB 3.3 Inactive DFGin ABAminus in-in in-in 3ND Type1 7 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3NDMC 3.3 Inactive DFGin ABAminus in-in in-none 3ND Type1 6 - 402 None None 5
Homo sapiens ROCK1_HUMAN 3NDMD 3.3 Inactive DFGin ABAminus in-in in-in 3ND Type1 7 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5WNFA 2.45 Inactive DFGin ABAminus in-in in-in B4V Type1 7 - 401 None None 0
Homo sapiens ROCK1_HUMAN 5WNFB 2.45 Inactive DFGin ABAminus in-in in-none B4V Type1 6 - 402 None None 7
Homo sapiens ROCK1_HUMAN 5WNFC 2.45 Inactive DFGin ABAminus in-in in-in B4V Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5WNFD 2.45 Inactive DFGin ABAminus in-in in-in B4V Type1 7 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5WNGA 2.9 Inactive DFGin ABAminus in-in in-in B4Y Type1 7 - 401 None None 0
Homo sapiens ROCK1_HUMAN 5WNGB 2.9 Inactive DFGin ABAminus in-in in-none B4Y Type1 6 - 402 None None 7
Homo sapiens ROCK1_HUMAN 5WNGC 2.9 Inactive DFGin ABAminus in-in in-in B4Y Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5WNGD 2.9 Inactive DFGin ABAminus in-in in-in B4Y Type1 7 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5WNHA 3.1 Inactive DFGin ABAminus in-in in-in B5G Type1 6 - 401 None None 0
Homo sapiens ROCK1_HUMAN 5WNHB 3.1 Inactive DFGin ABAminus in-in in-none B5G Type1 6 - 402 None None 7
Homo sapiens ROCK1_HUMAN 5WNHC 3.1 Inactive DFGin ABAminus in-in in-in B5G Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5WNHD 3.1 Inactive DFGin ABAminus in-in in-in B5G Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 6E9WA 2.96 Inactive DFGin ABAminus in-in in-in J0P Type1 9 - 404 None None 0
Homo sapiens ROCK1_HUMAN 6E9WB 2.96 Inactive DFGin ABAminus in-in in-out J0P Type1 7 - 401 None None 0
Homo sapiens ROCK1_HUMAN AF-Q13464-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 68 - 346 None None 0
Homo sapiens ROCK1_HUMAN 7S26D 2.744 None DFGin BLAminus in-in in-none No_ligand No_ligand 6 - 399 None None 23
Homo sapiens ROCK1_HUMAN 7S26A 2.744 None DFGin BLAminus in-in in-none 86K Type1 6 - 401 None None 6
Homo sapiens ROCK1_HUMAN 7S26B 2.744 None DFGin BLAminus in-in none-none 86K Type1 6 - 402 None None 19
Homo sapiens ROCK1_HUMAN 2V55A 3.705 Active DFGin BLAminus in-in in-in ANP Type1 6 - 404 None None 0
Homo sapiens ROCK1_HUMAN 2V55C 3.705 Active DFGin BLAminus in-in in-in ANP Type1 6 - 404 None None 0
Homo sapiens ROCK1_HUMAN 3TV7A 2.75 Inactive DFGin BLAminus in-in in-out 07Q Type1 9 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3TV7B 2.75 Inactive DFGin BLAminus in-in in-out 07Q Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3TV7C 2.75 Inactive DFGin BLAminus in-in in-out 07Q Type1 9 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3TV7D 2.75 Inactive DFGin BLAminus in-in in-out 07Q Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3V8SA 2.286 Active DFGin BLAminus in-in in-in 0HD Type1 8 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3V8SB 2.286 Inactive DFGin BLAminus in-in in-out 0HD Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3V8SC 2.286 Active DFGin BLAminus in-in in-in 0HD Type1 8 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3V8SD 2.286 Inactive DFGin BLAminus in-in in-out 0HD Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 4W7PA 2.8 Active DFGin BLAminus in-in in-in 3J7 Type1 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 4W7PB 2.8 Active DFGin BLAminus in-in in-in 3J7 Type1 6 - 401 None None 0
Homo sapiens ROCK1_HUMAN 4W7PC 2.8 Active DFGin BLAminus in-in in-in 3J7 Type1 6 - 401 None None 0
Homo sapiens ROCK1_HUMAN 4W7PD 2.8 Active DFGin BLAminus in-in in-in 3J7 Type1 6 - 403 None None 0
Homo sapiens ROCK1_HUMAN 7JOUA 3.318 Active DFGin BLAminus in-in in-in VFS Type1 9 - 402 None None 0
Homo sapiens ROCK1_HUMAN 2ESMA 3.2 Active DFGin BLAminus in-in in-in M77 Type1 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 2ESMB 3.2 Inactive DFGin BLAminus in-in in-out M77 Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 2ETKA 2.96 Active DFGin BLAminus in-in in-in HFS Type1 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 2ETKB 2.96 Inactive DFGin BLAminus in-in in-out HFS Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 2ETRA 2.6 Active DFGin BLAminus in-in in-in Y27 Type1 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 2ETRB 2.6 Inactive DFGin BLAminus in-in in-out Y27 Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3D9VA 3.3 Active DFGin BLAminus in-in in-in H52 Type1 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 3D9VB 3.3 Inactive DFGin BLAminus in-in in-out H52 Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 4YVCA 3.2 Active DFGin BLAminus in-in in-in 4KH Type1 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 4YVCB 3.2 Inactive DFGin BLAminus in-in in-out 4KH Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 4YVEA 3.4 Active DFGin BLAminus in-in in-in 4KK Type1 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 4YVEB 3.4 Inactive DFGin BLAminus in-in in-out 4KK Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5BMLA 2.95 Active DFGin BLAminus in-in in-in 4TW Type1 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 5BMLB 2.95 Inactive DFGin BLAminus in-in in-out 4TW Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5KKSA 3.3 Active DFGin BLAminus in-in in-in 6U1 Type1 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 5KKTA 2.8 Active DFGin BLAminus in-in in-in 6U2 Type1 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 5UZJA 3.3 Active DFGin BLAminus in-in in-in 8UV Type1 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 5UZJB 3.3 Inactive DFGin BLAminus in-in in-out 8UV Type1 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3TWJA 2.9 Inactive DFGin BLAminus in-in in-out 07R Type1.5_Back 7 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5HVUA 2.8 Active DFGin BLAminus in-in in-in 65R Type1.5_Front 6 - 405 None None 0
Homo sapiens ROCK1_HUMAN 5HVUB 2.8 None DFGin BLAminus in-in in-none 65R Type1.5_Front 6 - 402 None None 4
Homo sapiens ROCK1_HUMAN 5KKSB 3.3 Inactive DFGin BLAminus in-in in-out 6U1 Type1.5_Front 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5KKTB 2.8 Inactive DFGin BLAminus in-in in-out 6U2 Type1.5_Front 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5WNEA 2.6 Active DFGin BLAminus in-in in-in B4J Type1.5_Front 14 - 400 None None 0
Homo sapiens ROCK1_HUMAN 5WNEB 2.6 None DFGin BLAminus in-in in-none B4J Type1.5_Front 6 - 402 None None 9
Homo sapiens ROCK1_HUMAN 5WNEC 2.6 Active DFGin BLAminus in-in in-in B4J Type1.5_Front 6 - 402 None None 0
Homo sapiens ROCK1_HUMAN 5WNED 2.6 Active DFGin BLAminus in-in in-in B4J Type1.5_Front 7 - 402 None None 0
Homo sapiens ROCK1_HUMAN 7S26C 2.744 Inactive DFGin BLBminus in-in none-none 86K Type1 8 - 402 None None 18
Homo sapiens ROCK1_HUMAN 3TWJC 2.9 Inactive DFGin None in-out out-out 07R Type1 7 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3TWJB 2.9 Inactive DFGinter None in-in out-in No_ligand No_ligand 8 - 402 None None 0
Homo sapiens ROCK1_HUMAN 3TWJD 2.9 Inactive DFGinter None in-in out-in No_ligand No_ligand 8 - 402 None None 0
Homo sapiens ROCK1_HUMAN 7S25A 2.337 Inactive DFGout None in-in none-out 86G Type1 7 - 401 None None 17
Homo sapiens ROCK1_HUMAN 7S25B 2.337 Inactive DFGout None in-in none-out 86G Type1 8 - 402 None None 12
Homo sapiens ROCK1_HUMAN 7S25C 2.337 Inactive DFGout None in-in none-none 86G Type1 13 - 402 None None 18
Homo sapiens ROCK1_HUMAN 7S25D 2.337 Inactive None None in-in none-none No_ligand No_ligand 9 - 401 None None 29

ROCK1 (Rho-associated protein kinase 1)

No non-human structures known.