Protein kinases in complex with M77 (Fasudil)

Total number of genes: 3
Total number of chains: 5
Spatial Dihedral Chains Representative
DFGin BLAminus 5 5VEFA
All chains
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All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
AGC CDC42BPB MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta 3TKUA 2.15 Active DFGin BLAminus in-in in-in M77 M77 Type1 Allosteric
AGC CDC42BPB MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta 3TKUB 2.15 Active DFGin BLAminus in-in in-in M77 M77 Type1 Allosteric
AGC ROCK1 ROCK1_HUMAN Rho-associated protein kinase 1 2ESMA 3.2 Active DFGin BLAminus in-in in-in M77 Type1
AGC ROCK1 ROCK1_HUMAN Rho-associated protein kinase 1 2ESMB 3.2 Inactive DFGin BLAminus in-in in-out M77 Type1
STE PAK4 PAK4_HUMAN Serine/threonine-protein kinase PAK 4 5VEFA 1.752 Active DFGin BLAminus in-in in-in M77 Type1

Protein kinases in complex with M77

Total number of genes: 5
Total number of chains: 18
Spatial Dihedral Chains Representative
DFGin BLAminus 9 6EM2A
DFGin ABAminus 9 5LCPA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Bos taurus AGC PRKACA KAPCA_BOVIN cAMP-dependent protein kinase catalytic subunit alpha 2GNIA 2.27 Inactive DFGin ABAminus in-in in-in M77 Type1
Bos taurus AGC PRKACA KAPCA_BOVIN cAMP-dependent protein kinase catalytic subunit alpha 1Q8WA 2.2 Active DFGin BLAminus in-in in-in M77 Type1
Bos taurus AGC ROCK2 ROCK2_BOVIN Rho-associated protein kinase 2 2F2UA 2.4 Inactive DFGin ABAminus in-in in-in M77 Type1
Bos taurus AGC ROCK2 ROCK2_BOVIN Rho-associated protein kinase 2 2F2UB 2.4 Inactive DFGin BLAminus in-in in-out M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 5NW8A 2.086 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 5LCPA 1.433 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 5O0EA 1.5 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 5OK3A 1.588 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6ERWA 1.89 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6I2AA 1.75 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6I2CA 1.82 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6EM2A 1.3 Active DFGin BLAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6YNAA 1.47 Active DFGin BLAminus in-in in-in M77 Type1
Homo sapiens AGC CDC42BPB MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta 3TKUA 2.15 Active DFGin BLAminus in-in in-in M77 M77 Type1 Allosteric
Homo sapiens AGC CDC42BPB MRCKB_HUMAN Serine/threonine-protein kinase MRCK beta 3TKUB 2.15 Active DFGin BLAminus in-in in-in M77 M77 Type1 Allosteric
Homo sapiens AGC ROCK1 ROCK1_HUMAN Rho-associated protein kinase 1 2ESMA 3.2 Active DFGin BLAminus in-in in-in M77 Type1
Homo sapiens AGC ROCK1 ROCK1_HUMAN Rho-associated protein kinase 1 2ESMB 3.2 Inactive DFGin BLAminus in-in in-out M77 Type1
Homo sapiens STE PAK4 PAK4_HUMAN Serine/threonine-protein kinase PAK 4 5VEFA 1.752 Active DFGin BLAminus in-in in-in M77 Type1

Protein kinases in complex with M77

Total number of genes: 2
Total number of chains: 13
Spatial Dihedral Chains Representative
DFGin BLAminus 4 6EM2A
DFGin ABAminus 9 5LCPA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Bos taurus AGC PRKACA KAPCA_BOVIN cAMP-dependent protein kinase catalytic subunit alpha 2GNIA 2.27 Inactive DFGin ABAminus in-in in-in M77 Type1
Bos taurus AGC PRKACA KAPCA_BOVIN cAMP-dependent protein kinase catalytic subunit alpha 1Q8WA 2.2 Active DFGin BLAminus in-in in-in M77 Type1
Bos taurus AGC ROCK2 ROCK2_BOVIN Rho-associated protein kinase 2 2F2UA 2.4 Inactive DFGin ABAminus in-in in-in M77 Type1
Bos taurus AGC ROCK2 ROCK2_BOVIN Rho-associated protein kinase 2 2F2UB 2.4 Inactive DFGin BLAminus in-in in-out M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 5NW8A 2.086 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 5LCPA 1.433 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 5O0EA 1.5 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 5OK3A 1.588 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6ERWA 1.89 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6I2AA 1.75 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6I2CA 1.82 Inactive DFGin ABAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6EM2A 1.3 Active DFGin BLAminus in-in in-in M77 Type1
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 6YNAA 1.47 Active DFGin BLAminus in-in in-in M77 Type1