MELK (Maternal embryonic leucine zipper kinase)

Group: CAMK
Uniprot: MELK_HUMAN
Domain boundary: 11 - 263


Total number of chains: 51
Spatial Dihedral Chains Representative
DFGin BLAminus 39 AF-Q14680-K1A
DFGin ABAminus 2 4BL1A
DFGin BLBminus 1 5IHCA
DFGin None 2 5MAIA
DFGinter BABtrans 1 4IXPA
DFGinter None 2 4UMTA
DFGout None 1 5K00A
None None 3 6VXRA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
5TX3A 2.9 Inactive DFGin ABAminus out-out none-out 7MY Type1 1 - 333 None None 16
4BL1A 2.6 Inactive DFGin ABAminus in-in in-none ANP Type1 2 - 333 None None 14
AF-Q14680-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 3 - 271 None None 0
5TWUA 2.603 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 333 None None 7
5TWUB 2.603 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 335 None None 12
5IH8A 1.85 None DFGin BLAminus in-in in-none 6BJ Type1 3 - 327 None None 14
5IH9A 1.79 None DFGin BLAminus in-in in-none 6BF Type1 3 - 327 None None 14
5IHAA 1.96 None DFGin BLAminus in-in in-none 6BE Type1 3 - 327 None None 14
5TWZA 2.631 None DFGin BLAminus out-none none-out 45R Type1 2 - 333 None None 17
6GVXA 2.24 Active DFGin BLAminus in-in in-in TAK Type1 1 - 333 None None 7
6GVXB 2.24 Active DFGin BLAminus in-in in-in TAK Type1 1 - 335 None None 12
4BKYA 1.83 None DFGin BLAminus in-in in-none 82B Type1 3 - 333 None None 15
4BKZA 2.2 None DFGin BLAminus in-in in-none 1WS Type1 2 - 334 None None 15
5M5AA 1.9 None DFGin BLAminus in-in in-none KSA Type1 2 - 333 None None 15
5MAGA 2.35 None DFGin BLAminus in-in in-none 7KC Type1 3 - 335 None None 14
5MAHA 2.0 None DFGin BLAminus in-in in-none 7KD Type1 2 - 333 None None 14
4D2TA 2.7 Active DFGin BLAminus in-in in-in 3I7 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 12
4D2TB 2.7 Active DFGin BLAminus in-in in-in 3I7 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 6
4D2TC 2.7 Active DFGin BLAminus in-in in-in 3I7 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
4D2TD 2.7 Active DFGin BLAminus in-in in-in 3I7 Type1 3 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 8
4D2VA 2.45 None DFGin BLAminus in-in none-in 45R Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 15
4D2VB 2.45 Active DFGin BLAminus in-in in-in 45R Type1 2 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 6
4D2VC 2.45 Active DFGin BLAminus in-in in-in 45R Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
4D2VD 2.45 Active DFGin BLAminus in-in in-in 45R Type1 3 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 8
4D2WA 1.92 Active DFGin BLAminus in-in in-in NF5 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
4D2WB 1.92 Active DFGin BLAminus in-in in-in NF5 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 6
4D2WC 1.92 Active DFGin BLAminus in-in in-in NF5 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
4D2WD 1.92 Inactive DFGin BLAminus in-out in-in NF5 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 7
4UMPD 2.3 Active DFGin BLAminus in-in in-in 5QM Type1 2 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 7
4UMRA 3.0 None DFGin BLAminus out-out none-out QBB Type1 6 - 333 T167A,N213T,V214A,M215A,Y218V,K219A None 15
5TVTA 2.28 Active DFGin BLAminus in-in in-in 7LV Type1.5_Back 2 - 333 None None 13
5TWLA 2.42 None DFGin BLAminus in-in none-in H91 Type1.5_Back 2 - 333 None None 15
5MAFA 2.8 None DFGin BLAminus in-in out-none XIN Type1.5_Back 2 - 333 None None 14
4D2PA 2.55 Active DFGin BLAminus in-in in-in 6Z7 Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 14
4D2PB 2.55 Active DFGin BLAminus in-in in-in 6Z7 Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 6
4D2PC 2.55 Active DFGin BLAminus in-in in-in 6Z7 Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
4D2PD 2.55 Active DFGin BLAminus in-in in-in 6Z7 Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 7
4UMPA 2.3 Active DFGin BLAminus in-in in-in 5QM Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 14
4UMPB 2.3 Active DFGin BLAminus in-in in-in 5QM Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 6
4UMPC 2.3 Active DFGin BLAminus in-in in-in 5QM Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
4UMQA 2.6 None DFGin BLAminus out-out none-out B5S Type1.5_Back 5 - 333 T167A,N213T,V214A,M215A,Y218V,K219A None 15
5IHCA 2.14 Inactive DFGin BLBminus out-out none-none 6BB Type1 3 - 327 None None 18
5TWYA 2.91 Inactive DFGin None out-out none-out 7LY Type1 2 - 333 None None 15
5MAIA 2.15 Inactive DFGin None out-out none-none 5U5 Type1 2 - 333 None None 19
4IXPA 2.749 Inactive DFGinter BABtrans out-none out-out No_ligand No_ligand 2 - 335 K40R,D150A None 0
4UMTA 1.98 Inactive DFGinter None out-out none-out 47W Type1 3 - 333 N213T,V214A,M215A,Y218V,K219A None 15
4UMUA 2.02 Inactive DFGinter None out-out none-out 0V0 Type1 3 - 333 N213T,V214A,M215A,Y218V,K219A None 15
5K00A 1.77 Inactive DFGout None out-in out-none 6PV Type2 3 - 327 None None 13
6VXRA 2.1 Inactive None None out-none none-out F7D Type1 1 - 332 None None 18
5TWYB 2.91 Inactive None None out-none none-none 7LY Type1 2 - 332 None None 17
5TX3B 2.9 Inactive None None out-out none-in 7MY Type1 1 - 334 None None 19

MELK (Maternal embryonic leucine zipper kinase)

Group: CAMK
Total number of chains: 53
Spatial Dihedral Chains Representative
DFGin BLAminus 41 AF-Q14680-K1A
DFGin ABAminus 2 4BL1A
DFGin BLBminus 1 5IHCA
DFGin None 2 5MAIA
DFGinter BABtrans 1 4IXPA
DFGinter None 2 4UMTA
DFGout None 1 5K00A
None None 3 6VXRA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens MELK_HUMAN 5TX3A 2.9 Inactive DFGin ABAminus out-out none-out 7MY Type1 1 - 333 None None 16
Homo sapiens MELK_HUMAN 4BL1A 2.6 Inactive DFGin ABAminus in-in in-none ANP Type1 2 - 333 None None 14
Homo sapiens MELK_HUMAN AF-Q14680-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 3 - 271 None None 0
Homo sapiens MELK_HUMAN 5TWUA 2.603 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 333 None None 7
Homo sapiens MELK_HUMAN 5TWUB 2.603 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 335 None None 12
Homo sapiens MELK_HUMAN 5IH8A 1.85 None DFGin BLAminus in-in in-none 6BJ Type1 3 - 327 None None 14
Homo sapiens MELK_HUMAN 5IH9A 1.79 None DFGin BLAminus in-in in-none 6BF Type1 3 - 327 None None 14
Homo sapiens MELK_HUMAN 5IHAA 1.96 None DFGin BLAminus in-in in-none 6BE Type1 3 - 327 None None 14
Homo sapiens MELK_HUMAN 5TWZA 2.631 None DFGin BLAminus out-none none-out 45R Type1 2 - 333 None None 17
Homo sapiens MELK_HUMAN 6GVXA 2.24 Active DFGin BLAminus in-in in-in TAK Type1 1 - 333 None None 7
Homo sapiens MELK_HUMAN 6GVXB 2.24 Active DFGin BLAminus in-in in-in TAK Type1 1 - 335 None None 12
Homo sapiens MELK_HUMAN 4BKYA 1.83 None DFGin BLAminus in-in in-none 82B Type1 3 - 333 None None 15
Homo sapiens MELK_HUMAN 4BKZA 2.2 None DFGin BLAminus in-in in-none 1WS Type1 2 - 334 None None 15
Homo sapiens MELK_HUMAN 5M5AA 1.9 None DFGin BLAminus in-in in-none KSA Type1 2 - 333 None None 15
Homo sapiens MELK_HUMAN 5MAGA 2.35 None DFGin BLAminus in-in in-none 7KC Type1 3 - 335 None None 14
Homo sapiens MELK_HUMAN 5MAHA 2.0 None DFGin BLAminus in-in in-none 7KD Type1 2 - 333 None None 14
Homo sapiens MELK_HUMAN 4D2TA 2.7 Active DFGin BLAminus in-in in-in 3I7 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 12
Homo sapiens MELK_HUMAN 4D2TB 2.7 Active DFGin BLAminus in-in in-in 3I7 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 6
Homo sapiens MELK_HUMAN 4D2TC 2.7 Active DFGin BLAminus in-in in-in 3I7 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
Homo sapiens MELK_HUMAN 4D2TD 2.7 Active DFGin BLAminus in-in in-in 3I7 Type1 3 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 8
Homo sapiens MELK_HUMAN 4D2VA 2.45 None DFGin BLAminus in-in none-in 45R Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 15
Homo sapiens MELK_HUMAN 4D2VB 2.45 Active DFGin BLAminus in-in in-in 45R Type1 2 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 6
Homo sapiens MELK_HUMAN 4D2VC 2.45 Active DFGin BLAminus in-in in-in 45R Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
Homo sapiens MELK_HUMAN 4D2VD 2.45 Active DFGin BLAminus in-in in-in 45R Type1 3 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 8
Homo sapiens MELK_HUMAN 4D2WA 1.92 Active DFGin BLAminus in-in in-in NF5 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
Homo sapiens MELK_HUMAN 4D2WB 1.92 Active DFGin BLAminus in-in in-in NF5 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 6
Homo sapiens MELK_HUMAN 4D2WC 1.92 Active DFGin BLAminus in-in in-in NF5 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
Homo sapiens MELK_HUMAN 4D2WD 1.92 Inactive DFGin BLAminus in-out in-in NF5 Type1 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 7
Homo sapiens MELK_HUMAN 4UMPD 2.3 Active DFGin BLAminus in-in in-in 5QM Type1 2 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 7
Homo sapiens MELK_HUMAN 4UMRA 3.0 None DFGin BLAminus out-out none-out QBB Type1 6 - 333 T167A,N213T,V214A,M215A,Y218V,K219A None 15
Homo sapiens MELK_HUMAN 5TVTA 2.28 Active DFGin BLAminus in-in in-in 7LV Type1.5_Back 2 - 333 None None 13
Homo sapiens MELK_HUMAN 5TWLA 2.42 None DFGin BLAminus in-in none-in H91 Type1.5_Back 2 - 333 None None 15
Homo sapiens MELK_HUMAN 5MAFA 2.8 None DFGin BLAminus in-in out-none XIN Type1.5_Back 2 - 333 None None 14
Homo sapiens MELK_HUMAN 4D2PA 2.55 Active DFGin BLAminus in-in in-in 6Z7 Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 14
Homo sapiens MELK_HUMAN 4D2PB 2.55 Active DFGin BLAminus in-in in-in 6Z7 Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 6
Homo sapiens MELK_HUMAN 4D2PC 2.55 Active DFGin BLAminus in-in in-in 6Z7 Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
Homo sapiens MELK_HUMAN 4D2PD 2.55 Active DFGin BLAminus in-in in-in 6Z7 Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 7
Homo sapiens MELK_HUMAN 4UMPA 2.3 Active DFGin BLAminus in-in in-in 5QM Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 14
Homo sapiens MELK_HUMAN 4UMPB 2.3 Active DFGin BLAminus in-in in-in 5QM Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 6
Homo sapiens MELK_HUMAN 4UMPC 2.3 Active DFGin BLAminus in-in in-in 5QM Type1.5_Back 1 - 333 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None 13
Homo sapiens MELK_HUMAN 4UMQA 2.6 None DFGin BLAminus out-out none-out B5S Type1.5_Back 5 - 333 T167A,N213T,V214A,M215A,Y218V,K219A None 15
Homo sapiens MELK_HUMAN 5IHCA 2.14 Inactive DFGin BLBminus out-out none-none 6BB Type1 3 - 327 None None 18
Homo sapiens MELK_HUMAN 5TWYA 2.91 Inactive DFGin None out-out none-out 7LY Type1 2 - 333 None None 15
Homo sapiens MELK_HUMAN 5MAIA 2.15 Inactive DFGin None out-out none-none 5U5 Type1 2 - 333 None None 19
Homo sapiens MELK_HUMAN 4IXPA 2.749 Inactive DFGinter BABtrans out-none out-out No_ligand No_ligand 2 - 335 K40R,D150A None 0
Homo sapiens MELK_HUMAN 4UMTA 1.98 Inactive DFGinter None out-out none-out 47W Type1 3 - 333 N213T,V214A,M215A,Y218V,K219A None 15
Homo sapiens MELK_HUMAN 4UMUA 2.02 Inactive DFGinter None out-out none-out 0V0 Type1 3 - 333 N213T,V214A,M215A,Y218V,K219A None 15
Homo sapiens MELK_HUMAN 5K00A 1.77 Inactive DFGout None out-in out-none 6PV Type2 3 - 327 None None 13
Homo sapiens MELK_HUMAN 6VXRA 2.1 Inactive None None out-none none-out F7D Type1 1 - 332 None None 18
Homo sapiens MELK_HUMAN 5TWYB 2.91 Inactive None None out-none none-none 7LY Type1 2 - 332 None None 17
Homo sapiens MELK_HUMAN 5TX3B 2.9 Inactive None None out-out none-in 7MY Type1 1 - 334 None None 19
Mus musculus MELK_MOUSE 4CQGA 2.57 Active DFGin BLAminus in-in in-in OT5 Type1 2 - 326 T167E None 12
Mus musculus MELK_MOUSE 4BFMA 2.35 Active DFGin BLAminus in-in in-in ANP Type1 2 - 326 T167E None 12

MELK (Maternal embryonic leucine zipper kinase)

Group: CAMK
Total number of chains: 2
Spatial Dihedral Chains Representative
DFGin BLAminus 2 4BFMA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Mus musculus MELK_MOUSE 4CQGA 2.57 Active DFGin BLAminus in-in in-in OT5 Type1 2 - 326 T167E None 12
Mus musculus MELK_MOUSE 4BFMA 2.35 Active DFGin BLAminus in-in in-in ANP Type1 2 - 326 T167E None 12