5TWY

MELK (Maternal embryonic leucine zipper kinase)
Group: CAMK
Uniprot: MELK_HUMAN
Organism: Homo sapiens
Domain boundary: 11 - 263
Resolu: 2.91

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None out-out none-out 7LY Type1 2 - 333 15
B Inactive None None out-none none-none 7LY Type1 2 - 332 17
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
         9         19         29         39 
GSKDYDELLK YYELHETIGT ggfAKVKLAC HILTGEMVAI 
        49         59         69         79 
KIMDKNtlgs DLPRIKTEIE ALKNLRHQHI CQLYHVLETA 
        89         99        109        119 
NKIFMVLEYC PGGELFDYII SQDRLSEEET RVVFRQIVSA 
       129        139        149        159 
VAYVHSQGYA HRDLKPENLL FDEYHKLKLI DFGLCakpkg 
       169        179        189        199 
nkdyhlqtcc gsLAYAAPEL IQGKsylGSE ADVWSMGILL 
       209        219        229        239 
YVLMCGFLPF DDDNVMALYK KIMRGKYDVP KWLSPSSILL 
       249        259        269        279 
LQQMLQVDPK KRISMKNLLN HPWIMQDYNY PVEWQSKNPF 
       289        299        309        319 
IHLDDDCVTE LSVHHRNNRQ TMEDLISLWQ YDHLTATYLL 
       329        339 
LLAKKARGKP VRLrlssfsc g
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None