Protein kinases in complex with YY3 (Osimertinib)

Total number of genes: 1
Total number of chains: 20
Spatial Dihedral Chains Representative
DFGin BLAminus 6 6JX0A
DFGin BLBplus 13 7JXWC
DFGin BLBtrans 1 6JXTA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 9BY6A 2.551 Active DFGin BLAminus in-in in-in PDO YY3 Allosteric Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6JX4A 2.531 Active DFGin BLAminus in-in in-in YY3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6LUDA 2.05 Active DFGin BLAminus in-in in-in YY3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 4ZAUA 2.8 Active DFGin BLAminus in-in in-in YY3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6JWLA 2.551 Active DFGin BLAminus in-in in-in YY3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6JX0A 2.53 Active DFGin BLAminus in-in in-in YY3 YY3 Type1 Allosteric
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXMB 2.192 Inactive DFGin BLBplus out-out none-in YY3 9LL Type1 Type3
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXWA 2.5 Inactive DFGin BLBplus out-out none-out YY3 VNS Type1 Type3
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXWB 2.5 Inactive DFGin BLBplus out-out none-none YY3 VNS Type1 Type3
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXWC 2.5 Inactive DFGin BLBplus out-out out-in YY3 VNS Type1 Type3
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXWD 2.5 Inactive DFGin BLBplus out-out none-out YY3 VNS Type1 Type3
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXPC 2.16 Inactive DFGin BLBplus out-out none-in JBJ YY3 Type3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXPE 2.16 Inactive DFGin BLBplus out-out none-in JBJ YY3 Type3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HA 2.602 Inactive DFGin BLBplus out-out none-in VNS YY3 Type3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HB 2.602 Inactive DFGin BLBplus out-out none-in VNS YY3 Type3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HC 2.602 Inactive DFGin BLBplus out-out none-out VNS YY3 Type3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HD 2.602 Inactive DFGin BLBplus out-out out-out VNS YY3 Type3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HE 2.602 Inactive DFGin BLBplus out-out none-in VNS YY3 Type3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HF 2.602 Inactive DFGin BLBplus out-out none-out VNS YY3 Type3 Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6JXTA 2.307 Inactive DFGin BLBtrans out-out out-in YY3 Type1

Protein kinases in complex with YY3

Total number of genes: 1
Total number of chains: 20
Spatial Dihedral Chains Representative
DFGin BLAminus 6 6JX0A
DFGin BLBplus 13 7JXWC
DFGin BLBtrans 1 6JXTA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 9BY6A 2.551 Active DFGin BLAminus in-in in-in PDO YY3 Allosteric Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6JX4A 2.531 Active DFGin BLAminus in-in in-in YY3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6LUDA 2.05 Active DFGin BLAminus in-in in-in YY3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 4ZAUA 2.8 Active DFGin BLAminus in-in in-in YY3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6JWLA 2.551 Active DFGin BLAminus in-in in-in YY3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6JX0A 2.53 Active DFGin BLAminus in-in in-in YY3 YY3 Type1 Allosteric
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXMB 2.192 Inactive DFGin BLBplus out-out none-in YY3 9LL Type1 Type3
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXWA 2.5 Inactive DFGin BLBplus out-out none-out YY3 VNS Type1 Type3
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXWB 2.5 Inactive DFGin BLBplus out-out none-none YY3 VNS Type1 Type3
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXWC 2.5 Inactive DFGin BLBplus out-out out-in YY3 VNS Type1 Type3
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXWD 2.5 Inactive DFGin BLBplus out-out none-out YY3 VNS Type1 Type3
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXPC 2.16 Inactive DFGin BLBplus out-out none-in JBJ YY3 Type3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7JXPE 2.16 Inactive DFGin BLBplus out-out none-in JBJ YY3 Type3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HA 2.602 Inactive DFGin BLBplus out-out none-in VNS YY3 Type3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HB 2.602 Inactive DFGin BLBplus out-out none-in VNS YY3 Type3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HC 2.602 Inactive DFGin BLBplus out-out none-out VNS YY3 Type3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HD 2.602 Inactive DFGin BLBplus out-out out-out VNS YY3 Type3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HE 2.602 Inactive DFGin BLBplus out-out none-in VNS YY3 Type3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 7K1HF 2.602 Inactive DFGin BLBplus out-out none-out VNS YY3 Type3 Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 6JXTA 2.307 Inactive DFGin BLBtrans out-out out-in YY3 Type1

Protein kinases in complex with YY3

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type