Ligand: YY3 (Osimertinib)

Total number of chains: 19
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 13 68.4% 7JXWC
DFGin BLAminus 5 26.3% 6JX0A
DFGin BLBtrans 1 5.3% 6JXTA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 6JX4A P00533 696 1018 1210.0 YY3:1101 Type1 None DFGin 6.5376 15.2952 BLAminus -153.26, -174.41 59.27, 71.1 -94.69, 11.38 288.28, 101.84 -61.51, -40.3 in-in in 8.0887 Saltbr-in 3.1673 HRD-in -72.1, -56.13 75.51, 1.81 in-in-none SNCiin in-none ActLoopNT-in 2.7597 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 44.4 APE9-dihe-in -64.43, 143.52 APE8-dihe-in -93.62, 106.36 APE8-rot-na 34.75 APE67-dihe-in -65.07, -25.73 -81.11, -32.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.1371 APE9-dist-in 7.7928 T790M None None XRAY 2.531 0.213 0.245 A 331.0 315.0 8 30 22 8 [[712, 970]] 1.0 6jx4 TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6LUDA P00533 696 1018 1210.0 YY3:1101 Type1 Active DFGin 5.8015 15.1691 BLAminus -139.67, -168.77 58.93, 81.91 -96.56, 23.75 296.99, 89.34 -60.73, -21.77 in-in in 8.7131 Saltbr-in 3.0933 HRD-in -76.11, -49.39 70.4, 3.5 in-in-in SNCiii in-in ActLoopNT-in 2.8965 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.38, 124.7 APE9-dihe-in -132.42, 154.45 APE8-dihe-in -81.46, 86.05 APE8-rot-na 32.74 APE67-dihe-in -70.42, -2.77 -62.03, -42.63 APE12-dist-na 12.5916 APE11-dist-na 11.4701 APE10-dist-na 11.4847 APE9-dist-in 7.1538 T790M,C797S,L858R,E865A,E866A,K867A None None XRAY 2.05 0.207 0.222 A 329.0 310.0 4 30 30 0 [[712, 970]] 1.0 6lud TYR_EGFR_HUMAN TYR 3.4e-86 294.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZAUA P00533 698 1017 1210.0 YY3:1101 Type1 None DFGin 6.0169 15.4705 BLAminus -144.79, -170.19 56.78, 87.23 -105.06, 22.23 291.67, 100.52 -61.25, -22.95 in-in in 9.0925 Saltbr-in 3.5061 HRD-in -80.01, -54.39 75.7, 11.54 in-in-none SNCiin in-none ActLoopNT-in 2.8911 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 172.16 APE9-dihe-in -149.48, 142.85 APE8-dihe-in -76.13, 94.93 APE8-rot-na 357.17 APE67-dihe-in -79.77, -9.04 -61.73, -40.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.1938 APE9-dist-in 6.9548 None None None XRAY 2.8 0.196 0.244 A 330.0 283.0 14 30 25 5 [[712, 970]] 1.0 4zau TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6JWLA P00533 696 1020 1210.0 YY3:1101 Type1 Inactive DFGin 6.2675 15.1471 BLAminus -148.94, -172.35 58.18, 67.62 -92.49, 12.45 290.61, 97.33 -59.59, -36.09 in-in in 8.2927 Saltbr-in 2.9718 HRD-in -73.51, -46.95 65.44, 11.82 in-in-out SNCiio in-out ActLoopNT-in 2.9128 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 57.66, 41.1 APE9-dihe-in -69.1, 148.77 APE8-dihe-in -91.07, 95.73 APE8-rot-na 33.84 APE67-dihe-in -61.2, -38.42 -64.68, -39.82 APE12-dist-na 10.839 APE11-dist-na 11.9727 APE10-dist-na 11.9859 APE9-dist-in 7.6089 L858R None None XRAY 2.551 0.208 0.242 A 331.0 319.0 6 30 24 6 [[712, 970]] 1.0 6jwl TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6JX0A P00533 701 989 1210.0 YY3:1101,YY3:1102 Type1,Allosteric Active DFGin 5.6204 14.1815 BLAminus -159.3, -172.13 60.02, 72.45 -90.79, 10.95 286.73, 95.56 -60.06, -37.16 in-in in 8.6912 Saltbr-in 2.6654 HRD-in -72.92, -54.05 80.24, -1.58 in-in-in SNCiii in-in ActLoopNT-in 2.9094 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.1, 153.48 APE9-dihe-in -67.01, 145.59 APE8-dihe-in -63.12, 129.26 APE8-rot-na 333.49 APE67-dihe-in -73.75, -13.79 -61.59, -28.86 APE12-dist-na 9.4708 APE11-dist-na 10.6215 APE10-dist-na 11.2868 APE9-dist-in 6.0752 T790M None None XRAY 2.53 0.193 0.222 A 331.0 289.0 0 30 30 0 [[712, 970]] 1.0 6jx0 TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMB P00533 701 1012 1210.0 YY3:1101,9LL:1102 Type1,Type3 Inactive DFGin 5.1552 14.6479 BLBplus -133.95, 169.04 59.67, 39.65 -96.16, 166.65 49.37, 86.58 68.24, 16.57 out-out out 13.1662 Saltbr-out 10.454 HRD-in -67.1, -62.37 83.6, -7.78 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.13 APE8-dihe-in -90.39, 74.47 APE8-rot-na 39.92 APE67-dihe-in -71.29, -11.25 -51.45, -39.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7793 T790M,V948R None None XRAY 2.192 0.228 0.271 B 331.0 296.0 16 30 14 16 [[712, 970]] 1.0 7jxm TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXWA P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.579 14.666 BLBplus -138.64, 168.46 50.29, 44.7 -88.71, 170.77 52.75, 84.47 69.65, 17.94 out-out out 13.1767 Saltbr-out 9.9327 HRD-in -64.27, -62.7 83.56, -10.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -29.5 APE8-dihe-in -90.52, 58.97 APE8-rot-na 25.71 APE67-dihe-in -73.18, -5.87 -63.78, -37.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.655 T790M,V948R None None XRAY 2.5 0.276 0.319 A 331.0 288.0 20 30 14 16 [[712, 970]] 1.0 7jxw TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXWB P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.8888 14.5479 BLBplus -137.39, 167.04 52.05, 48.78 -89.33, 172.11 49.0, 84.75 70.86, 14.53 out-out out 12.8795 Saltbr-out 9.6401 HRD-in -63.98, -61.04 82.53, -9.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.58 APE8-rot-na 26.38 APE67-dihe-in -75.13, -4.52 -61.59, -34.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.5 0.276 0.319 B 331.0 291.0 17 30 13 17 [[712, 970]] 1.0 7jxw TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXWC P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.6443 14.3085 BLBplus -142.67, 169.6 56.07, 43.83 -87.93, 169.01 48.26, 81.62 68.95, 14.82 out-out out 13.3941 Saltbr-out 10.0598 HRD-in -68.52, -63.21 83.53, -10.12 out-out-none SNCoon out-none ActLoopNT-out 9.3722 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.99 APE8-dihe-in -72.85, 69.17 APE8-rot-na 25.57 APE67-dihe-in -79.13, -5.07 -61.58, -38.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7407 T790M,V948R None None XRAY 2.5 0.276 0.319 C 331.0 293.0 15 30 15 15 [[712, 970]] 1.0 7jxw TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXWD P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.4743 14.2146 BLBplus -140.27, 167.25 54.64, 43.57 -89.93, 170.58 53.09, 83.38 70.73, 14.16 out-out out 13.2865 Saltbr-out 10.1761 HRD-in -66.78, -61.63 83.28, -9.7 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.01 APE8-dihe-in -78.05, 71.87 APE8-rot-na 25.04 APE67-dihe-in -75.98, -6.06 -65.38, -38.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0117 T790M,V948R None None XRAY 2.5 0.276 0.319 D 331.0 287.0 21 30 13 17 [[712, 970]] 1.0 7jxw TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPC P00533 700 1007 1210.0 JBJ:1101,YY3:1102 Type3,Type1 Inactive DFGin 4.791 14.4893 BLBplus -135.14, 166.93 58.75, 39.54 -88.72, 165.62 50.16, 82.07 80.91, 11.4 out-out out 13.2148 Saltbr-out 10.0097 HRD-in -71.03, -65.61 90.59, -16.24 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.4 APE8-dihe-in -78.08, 71.31 APE8-rot-na 31.49 APE67-dihe-in -74.31, -4.1 -55.2, -45.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7338 T790M,V948R None None XRAY 2.16 0.214 0.247 C 331.0 292.0 16 30 14 16 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPE P00533 700 1007 1210.0 JBJ:1101,YY3:1102 Type3,Type1 Inactive DFGin 5.0169 14.7096 BLBplus -135.91, 163.38 57.21, 38.2 -87.34, 167.11 54.31, 95.16 79.16, 16.43 out-out out 13.5808 Saltbr-out 11.0085 HRD-in -68.91, -62.25 86.58, -12.8 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.81 APE8-dihe-in -81.71, 69.65 APE8-rot-na 31.8 APE67-dihe-in -77.02, -5.14 -52.47, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4598 T790M,V948R None None XRAY 2.16 0.214 0.247 E 331.0 287.0 16 30 14 16 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HA P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.8971 14.502 BLBplus -130.97, 170.62 58.17, 48.68 -100.05, 161.6 49.16, 78.42 69.2, 1.23 out-out out 13.7494 Saltbr-out 11.2637 HRD-in -77.07, -52.87 73.56, -9.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.57 APE8-dihe-in -79.59, 69.97 APE8-rot-na 32.69 APE67-dihe-in -73.02, -4.47 -58.4, -43.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8704 L858R,V948R None None XRAY 2.602 0.233 0.275 A 331.0 291.0 16 30 14 16 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HB P00533 701 1008 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.2454 14.5388 BLBplus -131.19, 172.0 58.43, 45.25 -101.59, 170.23 51.81, 92.29 77.64, 116.53 out-out out 13.4193 Saltbr-out 9.1369 HRD-in -79.53, -53.07 76.7, -9.03 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.65 APE8-dihe-in -81.29, 70.54 APE8-rot-na 31.4 APE67-dihe-in -72.0, -4.51 -57.97, -43.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9525 L858R,V948R None None XRAY 2.602 0.233 0.275 B 331.0 291.0 17 30 13 17 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HC P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.7437 14.7403 BLBplus -129.93, 170.49 56.69, 44.1 -96.18, 166.59 55.18, 77.55 73.78, 46.77 out-out out 13.4543 Saltbr-out 8.8337 HRD-in -79.27, -50.75 74.55, -8.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.24 APE8-dihe-in -82.15, 68.56 APE8-rot-na 31.93 APE67-dihe-in -74.95, -6.33 -58.99, -43.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0059 L858R,V948R None None XRAY 2.602 0.233 0.275 C 331.0 290.0 17 30 13 17 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HD P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.0186 14.8191 BLBplus -131.91, 172.88 57.19, 43.91 -99.27, 163.9 51.77, 84.58 74.04, -2.08 out-out out 13.6494 Saltbr-out 10.1563 HRD-in -78.62, -53.76 74.56, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.6801 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.98 APE8-dihe-in -78.93, 62.04 APE8-rot-na 29.95 APE67-dihe-in -73.79, -3.52 -56.56, -42.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0701 L858R,V948R None None XRAY 2.602 0.233 0.275 D 331.0 292.0 15 30 15 15 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HE P00533 703 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.1567 14.6352 BLBplus -131.84, 173.0 58.55, 47.55 -102.27, 167.87 51.85, 86.34 79.14, -85.43 out-out out 13.6294 Saltbr-out 10.3172 HRD-in -78.55, -50.1 74.47, -8.94 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.83 APE8-dihe-in -83.11, 68.71 APE8-rot-na 30.98 APE67-dihe-in -72.18, -4.84 -60.68, -43.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9904 L858R,V948R None None XRAY 2.602 0.233 0.275 E 331.0 289.0 16 30 14 16 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HF P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.9055 14.4208 BLBplus -132.01, 174.64 57.0, 46.09 -100.49, 170.69 50.88, 85.85 82.59, -107.03 out-out out 13.7173 Saltbr-out 10.9638 HRD-in -78.66, -52.82 76.59, -9.2 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.26 APE8-dihe-in -81.53, 68.79 APE8-rot-na 32.04 APE67-dihe-in -72.57, -5.45 -59.56, -43.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.067 L858R,V948R None None XRAY 2.602 0.233 0.275 F 331.0 290.0 17 30 13 17 [[712, 970]] 1.0 7k1h TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6JXTA P00533 697 984 1210.0 YY3:1101 Type1 Inactive DFGin 5.1951 16.5915 BLBtrans -111.23, 162.67 71.78, 29.16 -65.79, 134.38 147.38, 75.02 84.23, -1.16 out-out out 13.2952 Saltbr-out 13.347 HRD-in -69.01, -50.38 82.25, -13.8 out-out-in SNCooi out-in ActLoopNT-out 7.7418 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.48, 149.35 APE9-dihe-in -133.32, 157.03 APE8-dihe-in -83.78, 82.27 APE8-rot-na 27.63 APE67-dihe-in -60.52, -27.7 -61.29, -42.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.5844 APE9-dist-in 7.3679 E865A,E866A,K867A None None XRAY 2.307 0.218 0.239 A 331.0 284.0 4 30 28 2 [[712, 970]] 1.0 6jxt TYR_EGFR_HUMAN TYR 5.8e-87 297.3 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: YY3 (Osimertinib)

Total number of chains: 19
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 13 68.4% 7JXWC
DFGin BLAminus 5 26.3% 6JX0A
DFGin BLBtrans 1 5.3% 6JXTA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 6JX4A P00533 696 1018 1210.0 YY3:1101 Type1 None DFGin 6.5376 15.2952 BLAminus -153.26, -174.41 59.27, 71.1 -94.69, 11.38 288.28, 101.84 -61.51, -40.3 in-in in 8.0887 Saltbr-in 3.1673 HRD-in -72.1, -56.13 75.51, 1.81 in-in-none SNCiin in-none ActLoopNT-in 2.7597 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 44.4 APE9-dihe-in -64.43, 143.52 APE8-dihe-in -93.62, 106.36 APE8-rot-na 34.75 APE67-dihe-in -65.07, -25.73 -81.11, -32.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.1371 APE9-dist-in 7.7928 T790M None None XRAY 2.531 0.213 0.245 A 331.0 315.0 8 30 22 8 [[712, 970]] 1.0 6jx4 Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6LUDA P00533 696 1018 1210.0 YY3:1101 Type1 Active DFGin 5.8015 15.1691 BLAminus -139.67, -168.77 58.93, 81.91 -96.56, 23.75 296.99, 89.34 -60.73, -21.77 in-in in 8.7131 Saltbr-in 3.0933 HRD-in -76.11, -49.39 70.4, 3.5 in-in-in SNCiii in-in ActLoopNT-in 2.8965 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.38, 124.7 APE9-dihe-in -132.42, 154.45 APE8-dihe-in -81.46, 86.05 APE8-rot-na 32.74 APE67-dihe-in -70.42, -2.77 -62.03, -42.63 APE12-dist-na 12.5916 APE11-dist-na 11.4701 APE10-dist-na 11.4847 APE9-dist-in 7.1538 T790M,C797S,L858R,E865A,E866A,K867A None None XRAY 2.05 0.207 0.222 A 329.0 310.0 4 30 30 0 [[712, 970]] 1.0 6lud Homo sapiens TYR_EGFR_HUMAN TYR 3.4e-86 294.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZAUA P00533 698 1017 1210.0 YY3:1101 Type1 None DFGin 6.0169 15.4705 BLAminus -144.79, -170.19 56.78, 87.23 -105.06, 22.23 291.67, 100.52 -61.25, -22.95 in-in in 9.0925 Saltbr-in 3.5061 HRD-in -80.01, -54.39 75.7, 11.54 in-in-none SNCiin in-none ActLoopNT-in 2.8911 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 172.16 APE9-dihe-in -149.48, 142.85 APE8-dihe-in -76.13, 94.93 APE8-rot-na 357.17 APE67-dihe-in -79.77, -9.04 -61.73, -40.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.1938 APE9-dist-in 6.9548 None None None XRAY 2.8 0.196 0.244 A 330.0 283.0 14 30 25 5 [[712, 970]] 1.0 4zau Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6JWLA P00533 696 1020 1210.0 YY3:1101 Type1 Inactive DFGin 6.2675 15.1471 BLAminus -148.94, -172.35 58.18, 67.62 -92.49, 12.45 290.61, 97.33 -59.59, -36.09 in-in in 8.2927 Saltbr-in 2.9718 HRD-in -73.51, -46.95 65.44, 11.82 in-in-out SNCiio in-out ActLoopNT-in 2.9128 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 57.66, 41.1 APE9-dihe-in -69.1, 148.77 APE8-dihe-in -91.07, 95.73 APE8-rot-na 33.84 APE67-dihe-in -61.2, -38.42 -64.68, -39.82 APE12-dist-na 10.839 APE11-dist-na 11.9727 APE10-dist-na 11.9859 APE9-dist-in 7.6089 L858R None None XRAY 2.551 0.208 0.242 A 331.0 319.0 6 30 24 6 [[712, 970]] 1.0 6jwl Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6JX0A P00533 701 989 1210.0 YY3:1101,YY3:1102 Type1,Allosteric Active DFGin 5.6204 14.1815 BLAminus -159.3, -172.13 60.02, 72.45 -90.79, 10.95 286.73, 95.56 -60.06, -37.16 in-in in 8.6912 Saltbr-in 2.6654 HRD-in -72.92, -54.05 80.24, -1.58 in-in-in SNCiii in-in ActLoopNT-in 2.9094 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.1, 153.48 APE9-dihe-in -67.01, 145.59 APE8-dihe-in -63.12, 129.26 APE8-rot-na 333.49 APE67-dihe-in -73.75, -13.79 -61.59, -28.86 APE12-dist-na 9.4708 APE11-dist-na 10.6215 APE10-dist-na 11.2868 APE9-dist-in 6.0752 T790M None None XRAY 2.53 0.193 0.222 A 331.0 289.0 0 30 30 0 [[712, 970]] 1.0 6jx0 Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMB P00533 701 1012 1210.0 YY3:1101,9LL:1102 Type1,Type3 Inactive DFGin 5.1552 14.6479 BLBplus -133.95, 169.04 59.67, 39.65 -96.16, 166.65 49.37, 86.58 68.24, 16.57 out-out out 13.1662 Saltbr-out 10.454 HRD-in -67.1, -62.37 83.6, -7.78 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.13 APE8-dihe-in -90.39, 74.47 APE8-rot-na 39.92 APE67-dihe-in -71.29, -11.25 -51.45, -39.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7793 T790M,V948R None None XRAY 2.192 0.228 0.271 B 331.0 296.0 16 30 14 16 [[712, 970]] 1.0 7jxm Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXWA P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.579 14.666 BLBplus -138.64, 168.46 50.29, 44.7 -88.71, 170.77 52.75, 84.47 69.65, 17.94 out-out out 13.1767 Saltbr-out 9.9327 HRD-in -64.27, -62.7 83.56, -10.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -29.5 APE8-dihe-in -90.52, 58.97 APE8-rot-na 25.71 APE67-dihe-in -73.18, -5.87 -63.78, -37.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.655 T790M,V948R None None XRAY 2.5 0.276 0.319 A 331.0 288.0 20 30 14 16 [[712, 970]] 1.0 7jxw Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXWB P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.8888 14.5479 BLBplus -137.39, 167.04 52.05, 48.78 -89.33, 172.11 49.0, 84.75 70.86, 14.53 out-out out 12.8795 Saltbr-out 9.6401 HRD-in -63.98, -61.04 82.53, -9.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 67.58 APE8-rot-na 26.38 APE67-dihe-in -75.13, -4.52 -61.59, -34.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.5 0.276 0.319 B 331.0 291.0 17 30 13 17 [[712, 970]] 1.0 7jxw Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXWC P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.6443 14.3085 BLBplus -142.67, 169.6 56.07, 43.83 -87.93, 169.01 48.26, 81.62 68.95, 14.82 out-out out 13.3941 Saltbr-out 10.0598 HRD-in -68.52, -63.21 83.53, -10.12 out-out-none SNCoon out-none ActLoopNT-out 9.3722 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.99 APE8-dihe-in -72.85, 69.17 APE8-rot-na 25.57 APE67-dihe-in -79.13, -5.07 -61.58, -38.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7407 T790M,V948R None None XRAY 2.5 0.276 0.319 C 331.0 293.0 15 30 15 15 [[712, 970]] 1.0 7jxw Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXWD P00533 700 1007 1210.0 YY3:1301,VNS:1302 Type1,Type3 Inactive DFGin 4.4743 14.2146 BLBplus -140.27, 167.25 54.64, 43.57 -89.93, 170.58 53.09, 83.38 70.73, 14.16 out-out out 13.2865 Saltbr-out 10.1761 HRD-in -66.78, -61.63 83.28, -9.7 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.01 APE8-dihe-in -78.05, 71.87 APE8-rot-na 25.04 APE67-dihe-in -75.98, -6.06 -65.38, -38.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0117 T790M,V948R None None XRAY 2.5 0.276 0.319 D 331.0 287.0 21 30 13 17 [[712, 970]] 1.0 7jxw Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPC P00533 700 1007 1210.0 JBJ:1101,YY3:1102 Type3,Type1 Inactive DFGin 4.791 14.4893 BLBplus -135.14, 166.93 58.75, 39.54 -88.72, 165.62 50.16, 82.07 80.91, 11.4 out-out out 13.2148 Saltbr-out 10.0097 HRD-in -71.03, -65.61 90.59, -16.24 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.4 APE8-dihe-in -78.08, 71.31 APE8-rot-na 31.49 APE67-dihe-in -74.31, -4.1 -55.2, -45.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7338 T790M,V948R None None XRAY 2.16 0.214 0.247 C 331.0 292.0 16 30 14 16 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPE P00533 700 1007 1210.0 JBJ:1101,YY3:1102 Type3,Type1 Inactive DFGin 5.0169 14.7096 BLBplus -135.91, 163.38 57.21, 38.2 -87.34, 167.11 54.31, 95.16 79.16, 16.43 out-out out 13.5808 Saltbr-out 11.0085 HRD-in -68.91, -62.25 86.58, -12.8 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.81 APE8-dihe-in -81.71, 69.65 APE8-rot-na 31.8 APE67-dihe-in -77.02, -5.14 -52.47, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4598 T790M,V948R None None XRAY 2.16 0.214 0.247 E 331.0 287.0 16 30 14 16 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HA P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.8971 14.502 BLBplus -130.97, 170.62 58.17, 48.68 -100.05, 161.6 49.16, 78.42 69.2, 1.23 out-out out 13.7494 Saltbr-out 11.2637 HRD-in -77.07, -52.87 73.56, -9.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.57 APE8-dihe-in -79.59, 69.97 APE8-rot-na 32.69 APE67-dihe-in -73.02, -4.47 -58.4, -43.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8704 L858R,V948R None None XRAY 2.602 0.233 0.275 A 331.0 291.0 16 30 14 16 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HB P00533 701 1008 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.2454 14.5388 BLBplus -131.19, 172.0 58.43, 45.25 -101.59, 170.23 51.81, 92.29 77.64, 116.53 out-out out 13.4193 Saltbr-out 9.1369 HRD-in -79.53, -53.07 76.7, -9.03 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.65 APE8-dihe-in -81.29, 70.54 APE8-rot-na 31.4 APE67-dihe-in -72.0, -4.51 -57.97, -43.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9525 L858R,V948R None None XRAY 2.602 0.233 0.275 B 331.0 291.0 17 30 13 17 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HC P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.7437 14.7403 BLBplus -129.93, 170.49 56.69, 44.1 -96.18, 166.59 55.18, 77.55 73.78, 46.77 out-out out 13.4543 Saltbr-out 8.8337 HRD-in -79.27, -50.75 74.55, -8.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.24 APE8-dihe-in -82.15, 68.56 APE8-rot-na 31.93 APE67-dihe-in -74.95, -6.33 -58.99, -43.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0059 L858R,V948R None None XRAY 2.602 0.233 0.275 C 331.0 290.0 17 30 13 17 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HD P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.0186 14.8191 BLBplus -131.91, 172.88 57.19, 43.91 -99.27, 163.9 51.77, 84.58 74.04, -2.08 out-out out 13.6494 Saltbr-out 10.1563 HRD-in -78.62, -53.76 74.56, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.6801 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.98 APE8-dihe-in -78.93, 62.04 APE8-rot-na 29.95 APE67-dihe-in -73.79, -3.52 -56.56, -42.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0701 L858R,V948R None None XRAY 2.602 0.233 0.275 D 331.0 292.0 15 30 15 15 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HE P00533 703 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 5.1567 14.6352 BLBplus -131.84, 173.0 58.55, 47.55 -102.27, 167.87 51.85, 86.34 79.14, -85.43 out-out out 13.6294 Saltbr-out 10.3172 HRD-in -78.55, -50.1 74.47, -8.94 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.83 APE8-dihe-in -83.11, 68.71 APE8-rot-na 30.98 APE67-dihe-in -72.18, -4.84 -60.68, -43.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9904 L858R,V948R None None XRAY 2.602 0.233 0.275 E 331.0 289.0 16 30 14 16 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1HF P00533 701 1007 1210.0 VNS:1301,YY3:1302 Type3,Type1 Inactive DFGin 4.9055 14.4208 BLBplus -132.01, 174.64 57.0, 46.09 -100.49, 170.69 50.88, 85.85 82.59, -107.03 out-out out 13.7173 Saltbr-out 10.9638 HRD-in -78.66, -52.82 76.59, -9.2 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.26 APE8-dihe-in -81.53, 68.79 APE8-rot-na 32.04 APE67-dihe-in -72.57, -5.45 -59.56, -43.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.067 L858R,V948R None None XRAY 2.602 0.233 0.275 F 331.0 290.0 17 30 13 17 [[712, 970]] 1.0 7k1h Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6JXTA P00533 697 984 1210.0 YY3:1101 Type1 Inactive DFGin 5.1951 16.5915 BLBtrans -111.23, 162.67 71.78, 29.16 -65.79, 134.38 147.38, 75.02 84.23, -1.16 out-out out 13.2952 Saltbr-out 13.347 HRD-in -69.01, -50.38 82.25, -13.8 out-out-in SNCooi out-in ActLoopNT-out 7.7418 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.48, 149.35 APE9-dihe-in -133.32, 157.03 APE8-dihe-in -83.78, 82.27 APE8-rot-na 27.63 APE67-dihe-in -60.52, -27.7 -61.29, -42.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.5844 APE9-dist-in 7.3679 E865A,E866A,K867A None None XRAY 2.307 0.218 0.239 A 331.0 284.0 4 30 28 2 [[712, 970]] 1.0 6jxt Homo sapiens TYR_EGFR_HUMAN TYR 5.8e-87 297.3 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: YY3 (Osimertinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name