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| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | EGFR | EGFR_HUMAN | 6JX4A | P00533 | 696 | 1018 | 1210.0 | YY3:1101 | Type1 | None | DFGin | 6.538 | 15.295 | BLAminus | -153.26, -174.41 | 59.27, 71.1 | -94.69, 11.38 | 288.28, 101.84 | -61.51, -40.3 | in-in | in | 8.089 | Saltbr-in | 3.167 | HRD-in | -72.1, -56.13 | 75.51, 1.81 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.76 | ActLoopCT-none | TYR | APEdihe_niiai | APEdist_aaai | APE10-dihe-none | 999.0, 44.4 | APE9-dihe-in | -64.43, 143.52 | APE8-dihe-in | -93.62, 106.36 | APE8-rot-na | 34.75 | APE67-dihe-in | -65.07, -25.73 | -81.11, -32.49 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 12.137 | APE9-dist-in | 7.793 | T790M | None | None | XRAY | 2.531 | 0.213 | 0.245 | A | 331 | 315 | 8 | 0 | 0 | 8 | [[712, 970]] | 1.0 | 6jx4 | TYR_EGFR_HUMAN | TYR | 8.4e-88 | 300.1 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 6LUDA | P00533 | 696 | 1018 | 1210.0 | YY3:1101 | Type1 | Active | DFGin | 5.801 | 15.169 | BLAminus | -139.67, -168.77 | 58.93, 81.91 | -96.56, 23.75 | 296.99, 89.34 | -60.73, -21.77 | in-in | in | 8.713 | Saltbr-in | 3.093 | HRD-in | -76.11, -49.39 | 70.4, 3.5 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.897 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -75.38, 124.7 | APE9-dihe-in | -132.42, 154.45 | APE8-dihe-in | -81.46, 86.05 | APE8-rot-na | 32.74 | APE67-dihe-in | -70.42, -2.77 | -62.03, -42.63 | APE12-dist-na | 12.592 | APE11-dist-na | 11.47 | APE10-dist-na | 11.485 | APE9-dist-in | 7.154 | T790M,C797S,L858R,E865A,E866A,K867A | None | None | XRAY | 2.05 | 0.207 | 0.222 | A | 329 | 310 | 4 | 0 | 0 | 0 | [[712, 970]] | 1.0 | 6lud | TYR_EGFR_HUMAN | TYR | 3.4e-86 | 294.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4ZAUA | P00533 | 698 | 1017 | 1210.0 | YY3:1101 | Type1 | None | DFGin | 6.017 | 15.47 | BLAminus | -144.79, -170.19 | 56.78, 87.23 | -105.06, 22.23 | 291.67, 100.52 | -61.25, -22.95 | in-in | in | 9.092 | Saltbr-in | 3.506 | HRD-in | -80.01, -54.39 | 75.7, 11.54 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.891 | ActLoopCT-none | TYR | APEdihe_niiai | APEdist_aaai | APE10-dihe-none | 999.0, 172.16 | APE9-dihe-in | -149.48, 142.85 | APE8-dihe-in | -76.13, 94.93 | APE8-rot-na | 357.17 | APE67-dihe-in | -79.77, -9.04 | -61.73, -40.27 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 12.194 | APE9-dist-in | 6.955 | None | None | None | XRAY | 2.8 | 0.196 | 0.244 | A | 330 | 283 | 14 | 0 | 0 | 5 | [[712, 970]] | 1.0 | 4zau | TYR_EGFR_HUMAN | TYR | 1.1e-87 | 299.7 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 6JWLA | P00533 | 696 | 1020 | 1210.0 | YY3:1101 | Type1 | Inactive | DFGin | 6.268 | 15.147 | BLAminus | -148.94, -172.35 | 58.18, 67.62 | -92.49, 12.45 | 290.61, 97.33 | -59.59, -36.09 | in-in | in | 8.293 | Saltbr-in | 2.972 | HRD-in | -73.51, -46.95 | 65.44, 11.82 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.913 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | 57.66, 41.1 | APE9-dihe-in | -69.1, 148.77 | APE8-dihe-in | -91.07, 95.73 | APE8-rot-na | 33.84 | APE67-dihe-in | -61.2, -38.42 | -64.68, -39.82 | APE12-dist-na | 10.839 | APE11-dist-na | 11.973 | APE10-dist-na | 11.986 | APE9-dist-in | 7.609 | L858R | None | None | XRAY | 2.551 | 0.208 | 0.242 | A | 331 | 319 | 6 | 0 | 0 | 6 | [[712, 970]] | 1.0 | 6jwl | TYR_EGFR_HUMAN | TYR | 1.1e-86 | 296.4 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 6JX0A | P00533 | 701 | 989 | 1210.0 | YY3:1101,YY3:1102 | Type1,Allosteric | Active | DFGin | 5.62 | 14.181 | BLAminus | -159.3, -172.13 | 60.02, 72.45 | -90.79, 10.95 | 286.73, 95.56 | -60.06, -37.16 | in-in | in | 8.691 | Saltbr-in | 2.665 | HRD-in | -72.92, -54.05 | 80.24, -1.58 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.909 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -92.1, 153.48 | APE9-dihe-in | -67.01, 145.59 | APE8-dihe-in | -63.12, 129.26 | APE8-rot-na | 333.49 | APE67-dihe-in | -73.75, -13.79 | -61.59, -28.86 | APE12-dist-na | 9.471 | APE11-dist-na | 10.621 | APE10-dist-na | 11.287 | APE9-dist-in | 6.075 | T790M | None | None | XRAY | 2.53 | 0.193 | 0.222 | A | 331 | 289 | 0 | 0 | 0 | 0 | [[712, 970]] | 1.0 | 6jx0 | TYR_EGFR_HUMAN | TYR | 8.4e-88 | 300.1 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXMB | P00533 | 701 | 1012 | 1210.0 | YY3:1101,9LL:1102 | Type1,Type3 | Inactive | DFGin | 5.155 | 14.648 | BLBplus | -133.95, 169.04 | 59.67, 39.65 | -96.16, 166.65 | 49.37, 86.58 | 68.24, 16.57 | out-out | out | 13.166 | Saltbr-out | 10.454 | HRD-in | -67.1, -62.37 | 83.6, -7.78 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 126.13 | APE8-dihe-in | -90.39, 74.47 | APE8-rot-na | 39.92 | APE67-dihe-in | -71.29, -11.25 | -51.45, -39.54 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.779 | T790M,V948R | None | None | XRAY | 2.192 | 0.228 | 0.271 | B | 331 | 296 | 16 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7jxm | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXWA | P00533 | 700 | 1007 | 1210.0 | YY3:1301,VNS:1302 | Type1,Type3 | Inactive | DFGin | 4.579 | 14.666 | BLBplus | -138.64, 168.46 | 50.29, 44.7 | -88.71, 170.77 | 52.75, 84.47 | 69.65, 17.94 | out-out | out | 13.177 | Saltbr-out | 9.933 | HRD-in | -64.27, -62.7 | 83.56, -10.71 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, -29.5 | APE8-dihe-in | -90.52, 58.97 | APE8-rot-na | 25.71 | APE67-dihe-in | -73.18, -5.87 | -63.78, -37.62 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.655 | T790M,V948R | None | None | XRAY | 2.5 | 0.276 | 0.319 | A | 331 | 288 | 20 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7jxw | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXWB | P00533 | 700 | 1007 | 1210.0 | YY3:1301,VNS:1302 | Type1,Type3 | Inactive | DFGin | 4.889 | 14.548 | BLBplus | -137.39, 167.04 | 52.05, 48.78 | -89.33, 172.11 | 49.0, 84.75 | 70.86, 14.53 | out-out | out | 12.88 | Saltbr-out | 9.64 | HRD-in | -63.98, -61.04 | 82.53, -9.45 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, 67.58 | APE8-rot-na | 26.38 | APE67-dihe-in | -75.13, -4.52 | -61.59, -34.64 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | T790M,V948R | None | None | XRAY | 2.5 | 0.276 | 0.319 | B | 331 | 291 | 17 | 0 | 0 | 17 | [[712, 970]] | 1.0 | 7jxw | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXWC | P00533 | 700 | 1007 | 1210.0 | YY3:1301,VNS:1302 | Type1,Type3 | Inactive | DFGin | 4.644 | 14.309 | BLBplus | -142.67, 169.6 | 56.07, 43.83 | -87.93, 169.01 | 48.26, 81.62 | 68.95, 14.82 | out-out | out | 13.394 | Saltbr-out | 10.06 | HRD-in | -68.52, -63.21 | 83.53, -10.12 | out-out-none | SNCoon | out-none | ActLoopNT-out | 9.372 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 123.99 | APE8-dihe-in | -72.85, 69.17 | APE8-rot-na | 25.57 | APE67-dihe-in | -79.13, -5.07 | -61.58, -38.99 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.741 | T790M,V948R | None | None | XRAY | 2.5 | 0.276 | 0.319 | C | 331 | 293 | 15 | 0 | 0 | 15 | [[712, 970]] | 1.0 | 7jxw | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXWD | P00533 | 700 | 1007 | 1210.0 | YY3:1301,VNS:1302 | Type1,Type3 | Inactive | DFGin | 4.474 | 14.215 | BLBplus | -140.27, 167.25 | 54.64, 43.57 | -89.93, 170.58 | 53.09, 83.38 | 70.73, 14.16 | out-out | out | 13.287 | Saltbr-out | 10.176 | HRD-in | -66.78, -61.63 | 83.28, -9.7 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 134.01 | APE8-dihe-in | -78.05, 71.87 | APE8-rot-na | 25.04 | APE67-dihe-in | -75.98, -6.06 | -65.38, -38.44 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.012 | T790M,V948R | None | None | XRAY | 2.5 | 0.276 | 0.319 | D | 331 | 287 | 21 | 0 | 0 | 17 | [[712, 970]] | 1.0 | 7jxw | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXPC | P00533 | 700 | 1007 | 1210.0 | JBJ:1101,YY3:1102 | Type3,Type1 | Inactive | DFGin | 4.791 | 14.489 | BLBplus | -135.14, 166.93 | 58.75, 39.54 | -88.72, 165.62 | 50.16, 82.07 | 80.91, 11.4 | out-out | out | 13.215 | Saltbr-out | 10.01 | HRD-in | -71.03, -65.61 | 90.59, -16.24 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 133.4 | APE8-dihe-in | -78.08, 71.31 | APE8-rot-na | 31.49 | APE67-dihe-in | -74.31, -4.1 | -55.2, -45.03 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.734 | T790M,V948R | None | None | XRAY | 2.16 | 0.214 | 0.247 | C | 331 | 292 | 16 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7jxp | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXPE | P00533 | 700 | 1007 | 1210.0 | JBJ:1101,YY3:1102 | Type3,Type1 | Inactive | DFGin | 5.017 | 14.71 | BLBplus | -135.91, 163.38 | 57.21, 38.2 | -87.34, 167.11 | 54.31, 95.16 | 79.16, 16.43 | out-out | out | 13.581 | Saltbr-out | 11.008 | HRD-in | -68.91, -62.25 | 86.58, -12.8 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 129.81 | APE8-dihe-in | -81.71, 69.65 | APE8-rot-na | 31.8 | APE67-dihe-in | -77.02, -5.14 | -52.47, -41.73 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.46 | T790M,V948R | None | None | XRAY | 2.16 | 0.214 | 0.247 | E | 331 | 287 | 16 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7jxp | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HA | P00533 | 701 | 1007 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 4.897 | 14.502 | BLBplus | -130.97, 170.62 | 58.17, 48.68 | -100.05, 161.6 | 49.16, 78.42 | 69.2, 1.23 | out-out | out | 13.749 | Saltbr-out | 11.264 | HRD-in | -77.07, -52.87 | 73.56, -9.67 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 120.57 | APE8-dihe-in | -79.59, 69.97 | APE8-rot-na | 32.69 | APE67-dihe-in | -73.02, -4.47 | -58.4, -43.53 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.87 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | A | 331 | 291 | 16 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7k1h | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HB | P00533 | 701 | 1008 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 5.245 | 14.539 | BLBplus | -131.19, 172.0 | 58.43, 45.25 | -101.59, 170.23 | 51.81, 92.29 | 77.64, 116.53 | out-out | out | 13.419 | Saltbr-out | 9.137 | HRD-in | -79.53, -53.07 | 76.7, -9.03 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 117.65 | APE8-dihe-in | -81.29, 70.54 | APE8-rot-na | 31.4 | APE67-dihe-in | -72.0, -4.51 | -57.97, -43.84 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.952 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | B | 331 | 291 | 17 | 0 | 0 | 17 | [[712, 970]] | 1.0 | 7k1h | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HC | P00533 | 701 | 1007 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 4.744 | 14.74 | BLBplus | -129.93, 170.49 | 56.69, 44.1 | -96.18, 166.59 | 55.18, 77.55 | 73.78, 46.77 | out-out | out | 13.454 | Saltbr-out | 8.834 | HRD-in | -79.27, -50.75 | 74.55, -8.77 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 118.24 | APE8-dihe-in | -82.15, 68.56 | APE8-rot-na | 31.93 | APE67-dihe-in | -74.95, -6.33 | -58.99, -43.36 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.006 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | C | 331 | 290 | 17 | 0 | 0 | 17 | [[712, 970]] | 1.0 | 7k1h | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HD | P00533 | 701 | 1007 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 5.019 | 14.819 | BLBplus | -131.91, 172.88 | 57.19, 43.91 | -99.27, 163.9 | 51.77, 84.58 | 74.04, -2.08 | out-out | out | 13.649 | Saltbr-out | 10.156 | HRD-in | -78.62, -53.76 | 74.56, -9.86 | out-out-out | SNCooo | out-out | ActLoopNT-out | 9.68 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 117.98 | APE8-dihe-in | -78.93, 62.04 | APE8-rot-na | 29.95 | APE67-dihe-in | -73.79, -3.52 | -56.56, -42.2 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.07 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | D | 331 | 292 | 15 | 0 | 0 | 15 | [[712, 970]] | 1.0 | 7k1h | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HE | P00533 | 703 | 1007 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 5.157 | 14.635 | BLBplus | -131.84, 173.0 | 58.55, 47.55 | -102.27, 167.87 | 51.85, 86.34 | 79.14, -85.43 | out-out | out | 13.629 | Saltbr-out | 10.317 | HRD-in | -78.55, -50.1 | 74.47, -8.94 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 114.83 | APE8-dihe-in | -83.11, 68.71 | APE8-rot-na | 30.98 | APE67-dihe-in | -72.18, -4.84 | -60.68, -43.88 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.99 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | E | 331 | 289 | 16 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7k1h | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HF | P00533 | 701 | 1007 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 4.905 | 14.421 | BLBplus | -132.01, 174.64 | 57.0, 46.09 | -100.49, 170.69 | 50.88, 85.85 | 82.59, -107.03 | out-out | out | 13.717 | Saltbr-out | 10.964 | HRD-in | -78.66, -52.82 | 76.59, -9.2 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 119.26 | APE8-dihe-in | -81.53, 68.79 | APE8-rot-na | 32.04 | APE67-dihe-in | -72.57, -5.45 | -59.56, -43.26 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.067 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | F | 331 | 290 | 17 | 0 | 0 | 17 | [[712, 970]] | 1.0 | 7k1h | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 6JXTA | P00533 | 697 | 984 | 1210.0 | YY3:1101 | Type1 | Inactive | DFGin | 5.195 | 16.591 | BLBtrans | -111.23, 162.67 | 71.78, 29.16 | -65.79, 134.38 | 147.38, 75.02 | 84.23, -1.16 | out-out | out | 13.295 | Saltbr-out | 13.347 | HRD-in | -69.01, -50.38 | 82.25, -13.8 | out-out-in | SNCooi | out-in | ActLoopNT-out | 7.742 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -66.48, 149.35 | APE9-dihe-in | -133.32, 157.03 | APE8-dihe-in | -83.78, 82.27 | APE8-rot-na | 27.63 | APE67-dihe-in | -60.52, -27.7 | -61.29, -42.33 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 13.584 | APE9-dist-in | 7.368 | E865A,E866A,K867A | None | None | XRAY | 2.307 | 0.218 | 0.239 | A | 331 | 284 | 4 | 0 | 0 | 2 | [[712, 970]] | 1.0 | 6jxt | TYR_EGFR_HUMAN | TYR | 5.8e-87 | 297.3 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | EGFR | EGFR_HUMAN | 6JX4A | P00533 | 696 | 1018 | 1210.0 | YY3:1101 | Type1 | None | DFGin | 6.538 | 15.295 | BLAminus | -153.26, -174.41 | 59.27, 71.1 | -94.69, 11.38 | 288.28, 101.84 | -61.51, -40.3 | in-in | in | 8.089 | Saltbr-in | 3.167 | HRD-in | -72.1, -56.13 | 75.51, 1.81 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.76 | ActLoopCT-none | TYR | APEdihe_niiai | APEdist_aaai | APE10-dihe-none | 999.0, 44.4 | APE9-dihe-in | -64.43, 143.52 | APE8-dihe-in | -93.62, 106.36 | APE8-rot-na | 34.75 | APE67-dihe-in | -65.07, -25.73 | -81.11, -32.49 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 12.137 | APE9-dist-in | 7.793 | T790M | None | None | XRAY | 2.531 | 0.213 | 0.245 | A | 331 | 315 | 8 | 0 | 0 | 8 | [[712, 970]] | 1.0 | 6jx4 | Homo sapiens | TYR_EGFR_HUMAN | TYR | 8.4e-88 | 300.1 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 6LUDA | P00533 | 696 | 1018 | 1210.0 | YY3:1101 | Type1 | Active | DFGin | 5.801 | 15.169 | BLAminus | -139.67, -168.77 | 58.93, 81.91 | -96.56, 23.75 | 296.99, 89.34 | -60.73, -21.77 | in-in | in | 8.713 | Saltbr-in | 3.093 | HRD-in | -76.11, -49.39 | 70.4, 3.5 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.897 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -75.38, 124.7 | APE9-dihe-in | -132.42, 154.45 | APE8-dihe-in | -81.46, 86.05 | APE8-rot-na | 32.74 | APE67-dihe-in | -70.42, -2.77 | -62.03, -42.63 | APE12-dist-na | 12.592 | APE11-dist-na | 11.47 | APE10-dist-na | 11.485 | APE9-dist-in | 7.154 | T790M,C797S,L858R,E865A,E866A,K867A | None | None | XRAY | 2.05 | 0.207 | 0.222 | A | 329 | 310 | 4 | 0 | 0 | 0 | [[712, 970]] | 1.0 | 6lud | Homo sapiens | TYR_EGFR_HUMAN | TYR | 3.4e-86 | 294.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4ZAUA | P00533 | 698 | 1017 | 1210.0 | YY3:1101 | Type1 | None | DFGin | 6.017 | 15.47 | BLAminus | -144.79, -170.19 | 56.78, 87.23 | -105.06, 22.23 | 291.67, 100.52 | -61.25, -22.95 | in-in | in | 9.092 | Saltbr-in | 3.506 | HRD-in | -80.01, -54.39 | 75.7, 11.54 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.891 | ActLoopCT-none | TYR | APEdihe_niiai | APEdist_aaai | APE10-dihe-none | 999.0, 172.16 | APE9-dihe-in | -149.48, 142.85 | APE8-dihe-in | -76.13, 94.93 | APE8-rot-na | 357.17 | APE67-dihe-in | -79.77, -9.04 | -61.73, -40.27 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 12.194 | APE9-dist-in | 6.955 | None | None | None | XRAY | 2.8 | 0.196 | 0.244 | A | 330 | 283 | 14 | 0 | 0 | 5 | [[712, 970]] | 1.0 | 4zau | Homo sapiens | TYR_EGFR_HUMAN | TYR | 1.1e-87 | 299.7 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 6JWLA | P00533 | 696 | 1020 | 1210.0 | YY3:1101 | Type1 | Inactive | DFGin | 6.268 | 15.147 | BLAminus | -148.94, -172.35 | 58.18, 67.62 | -92.49, 12.45 | 290.61, 97.33 | -59.59, -36.09 | in-in | in | 8.293 | Saltbr-in | 2.972 | HRD-in | -73.51, -46.95 | 65.44, 11.82 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.913 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | 57.66, 41.1 | APE9-dihe-in | -69.1, 148.77 | APE8-dihe-in | -91.07, 95.73 | APE8-rot-na | 33.84 | APE67-dihe-in | -61.2, -38.42 | -64.68, -39.82 | APE12-dist-na | 10.839 | APE11-dist-na | 11.973 | APE10-dist-na | 11.986 | APE9-dist-in | 7.609 | L858R | None | None | XRAY | 2.551 | 0.208 | 0.242 | A | 331 | 319 | 6 | 0 | 0 | 6 | [[712, 970]] | 1.0 | 6jwl | Homo sapiens | TYR_EGFR_HUMAN | TYR | 1.1e-86 | 296.4 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 6JX0A | P00533 | 701 | 989 | 1210.0 | YY3:1101,YY3:1102 | Type1,Allosteric | Active | DFGin | 5.62 | 14.181 | BLAminus | -159.3, -172.13 | 60.02, 72.45 | -90.79, 10.95 | 286.73, 95.56 | -60.06, -37.16 | in-in | in | 8.691 | Saltbr-in | 2.665 | HRD-in | -72.92, -54.05 | 80.24, -1.58 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.909 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -92.1, 153.48 | APE9-dihe-in | -67.01, 145.59 | APE8-dihe-in | -63.12, 129.26 | APE8-rot-na | 333.49 | APE67-dihe-in | -73.75, -13.79 | -61.59, -28.86 | APE12-dist-na | 9.471 | APE11-dist-na | 10.621 | APE10-dist-na | 11.287 | APE9-dist-in | 6.075 | T790M | None | None | XRAY | 2.53 | 0.193 | 0.222 | A | 331 | 289 | 0 | 0 | 0 | 0 | [[712, 970]] | 1.0 | 6jx0 | Homo sapiens | TYR_EGFR_HUMAN | TYR | 8.4e-88 | 300.1 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXMB | P00533 | 701 | 1012 | 1210.0 | YY3:1101,9LL:1102 | Type1,Type3 | Inactive | DFGin | 5.155 | 14.648 | BLBplus | -133.95, 169.04 | 59.67, 39.65 | -96.16, 166.65 | 49.37, 86.58 | 68.24, 16.57 | out-out | out | 13.166 | Saltbr-out | 10.454 | HRD-in | -67.1, -62.37 | 83.6, -7.78 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 126.13 | APE8-dihe-in | -90.39, 74.47 | APE8-rot-na | 39.92 | APE67-dihe-in | -71.29, -11.25 | -51.45, -39.54 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.779 | T790M,V948R | None | None | XRAY | 2.192 | 0.228 | 0.271 | B | 331 | 296 | 16 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7jxm | Homo sapiens | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXWA | P00533 | 700 | 1007 | 1210.0 | YY3:1301,VNS:1302 | Type1,Type3 | Inactive | DFGin | 4.579 | 14.666 | BLBplus | -138.64, 168.46 | 50.29, 44.7 | -88.71, 170.77 | 52.75, 84.47 | 69.65, 17.94 | out-out | out | 13.177 | Saltbr-out | 9.933 | HRD-in | -64.27, -62.7 | 83.56, -10.71 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, -29.5 | APE8-dihe-in | -90.52, 58.97 | APE8-rot-na | 25.71 | APE67-dihe-in | -73.18, -5.87 | -63.78, -37.62 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.655 | T790M,V948R | None | None | XRAY | 2.5 | 0.276 | 0.319 | A | 331 | 288 | 20 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7jxw | Homo sapiens | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXWB | P00533 | 700 | 1007 | 1210.0 | YY3:1301,VNS:1302 | Type1,Type3 | Inactive | DFGin | 4.889 | 14.548 | BLBplus | -137.39, 167.04 | 52.05, 48.78 | -89.33, 172.11 | 49.0, 84.75 | 70.86, 14.53 | out-out | out | 12.88 | Saltbr-out | 9.64 | HRD-in | -63.98, -61.04 | 82.53, -9.45 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, 67.58 | APE8-rot-na | 26.38 | APE67-dihe-in | -75.13, -4.52 | -61.59, -34.64 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | T790M,V948R | None | None | XRAY | 2.5 | 0.276 | 0.319 | B | 331 | 291 | 17 | 0 | 0 | 17 | [[712, 970]] | 1.0 | 7jxw | Homo sapiens | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXWC | P00533 | 700 | 1007 | 1210.0 | YY3:1301,VNS:1302 | Type1,Type3 | Inactive | DFGin | 4.644 | 14.309 | BLBplus | -142.67, 169.6 | 56.07, 43.83 | -87.93, 169.01 | 48.26, 81.62 | 68.95, 14.82 | out-out | out | 13.394 | Saltbr-out | 10.06 | HRD-in | -68.52, -63.21 | 83.53, -10.12 | out-out-none | SNCoon | out-none | ActLoopNT-out | 9.372 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 123.99 | APE8-dihe-in | -72.85, 69.17 | APE8-rot-na | 25.57 | APE67-dihe-in | -79.13, -5.07 | -61.58, -38.99 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.741 | T790M,V948R | None | None | XRAY | 2.5 | 0.276 | 0.319 | C | 331 | 293 | 15 | 0 | 0 | 15 | [[712, 970]] | 1.0 | 7jxw | Homo sapiens | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXWD | P00533 | 700 | 1007 | 1210.0 | YY3:1301,VNS:1302 | Type1,Type3 | Inactive | DFGin | 4.474 | 14.215 | BLBplus | -140.27, 167.25 | 54.64, 43.57 | -89.93, 170.58 | 53.09, 83.38 | 70.73, 14.16 | out-out | out | 13.287 | Saltbr-out | 10.176 | HRD-in | -66.78, -61.63 | 83.28, -9.7 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 134.01 | APE8-dihe-in | -78.05, 71.87 | APE8-rot-na | 25.04 | APE67-dihe-in | -75.98, -6.06 | -65.38, -38.44 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.012 | T790M,V948R | None | None | XRAY | 2.5 | 0.276 | 0.319 | D | 331 | 287 | 21 | 0 | 0 | 17 | [[712, 970]] | 1.0 | 7jxw | Homo sapiens | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXPC | P00533 | 700 | 1007 | 1210.0 | JBJ:1101,YY3:1102 | Type3,Type1 | Inactive | DFGin | 4.791 | 14.489 | BLBplus | -135.14, 166.93 | 58.75, 39.54 | -88.72, 165.62 | 50.16, 82.07 | 80.91, 11.4 | out-out | out | 13.215 | Saltbr-out | 10.01 | HRD-in | -71.03, -65.61 | 90.59, -16.24 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 133.4 | APE8-dihe-in | -78.08, 71.31 | APE8-rot-na | 31.49 | APE67-dihe-in | -74.31, -4.1 | -55.2, -45.03 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.734 | T790M,V948R | None | None | XRAY | 2.16 | 0.214 | 0.247 | C | 331 | 292 | 16 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7jxp | Homo sapiens | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7JXPE | P00533 | 700 | 1007 | 1210.0 | JBJ:1101,YY3:1102 | Type3,Type1 | Inactive | DFGin | 5.017 | 14.71 | BLBplus | -135.91, 163.38 | 57.21, 38.2 | -87.34, 167.11 | 54.31, 95.16 | 79.16, 16.43 | out-out | out | 13.581 | Saltbr-out | 11.008 | HRD-in | -68.91, -62.25 | 86.58, -12.8 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 129.81 | APE8-dihe-in | -81.71, 69.65 | APE8-rot-na | 31.8 | APE67-dihe-in | -77.02, -5.14 | -52.47, -41.73 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.46 | T790M,V948R | None | None | XRAY | 2.16 | 0.214 | 0.247 | E | 331 | 287 | 16 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7jxp | Homo sapiens | TYR_EGFR_HUMAN | TYR | 6.3e-88 | 300.5 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HA | P00533 | 701 | 1007 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 4.897 | 14.502 | BLBplus | -130.97, 170.62 | 58.17, 48.68 | -100.05, 161.6 | 49.16, 78.42 | 69.2, 1.23 | out-out | out | 13.749 | Saltbr-out | 11.264 | HRD-in | -77.07, -52.87 | 73.56, -9.67 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 120.57 | APE8-dihe-in | -79.59, 69.97 | APE8-rot-na | 32.69 | APE67-dihe-in | -73.02, -4.47 | -58.4, -43.53 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.87 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | A | 331 | 291 | 16 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7k1h | Homo sapiens | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HB | P00533 | 701 | 1008 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 5.245 | 14.539 | BLBplus | -131.19, 172.0 | 58.43, 45.25 | -101.59, 170.23 | 51.81, 92.29 | 77.64, 116.53 | out-out | out | 13.419 | Saltbr-out | 9.137 | HRD-in | -79.53, -53.07 | 76.7, -9.03 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 117.65 | APE8-dihe-in | -81.29, 70.54 | APE8-rot-na | 31.4 | APE67-dihe-in | -72.0, -4.51 | -57.97, -43.84 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.952 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | B | 331 | 291 | 17 | 0 | 0 | 17 | [[712, 970]] | 1.0 | 7k1h | Homo sapiens | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HC | P00533 | 701 | 1007 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 4.744 | 14.74 | BLBplus | -129.93, 170.49 | 56.69, 44.1 | -96.18, 166.59 | 55.18, 77.55 | 73.78, 46.77 | out-out | out | 13.454 | Saltbr-out | 8.834 | HRD-in | -79.27, -50.75 | 74.55, -8.77 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 118.24 | APE8-dihe-in | -82.15, 68.56 | APE8-rot-na | 31.93 | APE67-dihe-in | -74.95, -6.33 | -58.99, -43.36 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.006 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | C | 331 | 290 | 17 | 0 | 0 | 17 | [[712, 970]] | 1.0 | 7k1h | Homo sapiens | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HD | P00533 | 701 | 1007 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 5.019 | 14.819 | BLBplus | -131.91, 172.88 | 57.19, 43.91 | -99.27, 163.9 | 51.77, 84.58 | 74.04, -2.08 | out-out | out | 13.649 | Saltbr-out | 10.156 | HRD-in | -78.62, -53.76 | 74.56, -9.86 | out-out-out | SNCooo | out-out | ActLoopNT-out | 9.68 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 117.98 | APE8-dihe-in | -78.93, 62.04 | APE8-rot-na | 29.95 | APE67-dihe-in | -73.79, -3.52 | -56.56, -42.2 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.07 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | D | 331 | 292 | 15 | 0 | 0 | 15 | [[712, 970]] | 1.0 | 7k1h | Homo sapiens | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HE | P00533 | 703 | 1007 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 5.157 | 14.635 | BLBplus | -131.84, 173.0 | 58.55, 47.55 | -102.27, 167.87 | 51.85, 86.34 | 79.14, -85.43 | out-out | out | 13.629 | Saltbr-out | 10.317 | HRD-in | -78.55, -50.1 | 74.47, -8.94 | out-none-none | SNConn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 114.83 | APE8-dihe-in | -83.11, 68.71 | APE8-rot-na | 30.98 | APE67-dihe-in | -72.18, -4.84 | -60.68, -43.88 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.99 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | E | 331 | 289 | 16 | 0 | 0 | 16 | [[712, 970]] | 1.0 | 7k1h | Homo sapiens | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 7K1HF | P00533 | 701 | 1007 | 1210.0 | VNS:1301,YY3:1302 | Type3,Type1 | Inactive | DFGin | 4.905 | 14.421 | BLBplus | -132.01, 174.64 | 57.0, 46.09 | -100.49, 170.69 | 50.88, 85.85 | 82.59, -107.03 | out-out | out | 13.717 | Saltbr-out | 10.964 | HRD-in | -78.66, -52.82 | 76.59, -9.2 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 119.26 | APE8-dihe-in | -81.53, 68.79 | APE8-rot-na | 32.04 | APE67-dihe-in | -72.57, -5.45 | -59.56, -43.26 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.067 | L858R,V948R | None | None | XRAY | 2.602 | 0.233 | 0.275 | F | 331 | 290 | 17 | 0 | 0 | 17 | [[712, 970]] | 1.0 | 7k1h | Homo sapiens | TYR_EGFR_HUMAN | TYR | 8.5e-87 | 296.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 6JXTA | P00533 | 697 | 984 | 1210.0 | YY3:1101 | Type1 | Inactive | DFGin | 5.195 | 16.591 | BLBtrans | -111.23, 162.67 | 71.78, 29.16 | -65.79, 134.38 | 147.38, 75.02 | 84.23, -1.16 | out-out | out | 13.295 | Saltbr-out | 13.347 | HRD-in | -69.01, -50.38 | 82.25, -13.8 | out-out-in | SNCooi | out-in | ActLoopNT-out | 7.742 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -66.48, 149.35 | APE9-dihe-in | -133.32, 157.03 | APE8-dihe-in | -83.78, 82.27 | APE8-rot-na | 27.63 | APE67-dihe-in | -60.52, -27.7 | -61.29, -42.33 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 13.584 | APE9-dist-in | 7.368 | E865A,E866A,K867A | None | None | XRAY | 2.307 | 0.218 | 0.239 | A | 331 | 284 | 4 | 0 | 0 | 2 | [[712, 970]] | 1.0 | 6jxt | Homo sapiens | TYR_EGFR_HUMAN | TYR | 5.8e-87 | 297.3 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|