Ligand: SB2

Total number of chains: 8
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 2 25.0% 1A9UA
DFGin BLBplus 2 25.0% 5AR4B
DFGinter None 2 25.0% 3ZS5A
DFGin BLAminus 1 12.5% 1PMEA
DFGin None 1 12.5% 3OBGA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC MAPK1 MK01_HUMAN 1PMEA 2.0 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiii APEdist_oiii SB2 Type1 16 - 360 0 None I103L,Q105T,D106H,E109G,T110A Mitogen-activated protein kinase 1
CMGC MAPK14 MK14_HUMAN 1A9UA 2.5 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SB2 Type1 4 - 354 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3MPAA 2.1 Inactive DFGin‑BLBminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 5 - 352 0 None D168G Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OBGA 2.8 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 5 - 352 0 None F169G Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3GCPA 2.25 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn SB2 Type1 4 - 352 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ZS5A 1.6 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno SB2 Type1 2 - 352 0 None None Mitogen-activated protein kinase 14
TKL RIPK2 RIPK2_HUMAN 5AR4A 2.7 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn SB2 Type1 5 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR4B 2.7 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno SB2 Type1 6 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2

Ligand: SB2

Total number of chains: 12
Active chains: 0
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 25.0% 8ACMAAA
DFGin None 3 25.0% 8ACOAAA
DFGin BLBminus 2 16.7% 1A9UA
DFGinter None 2 16.7% 3ZS5A
DFGin BLAminus 1 8.3% 1PMEA
DFGin BLAplus 1 8.3% 3UIBA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC MAPK1 MK01_HUMAN 1PMEA 2.0 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiii APEdist_oiii SB2 Type1 16 - 360 0 None I103L,Q105T,D106H,E109G,T110A Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK14 MK14_HUMAN 1A9UA 2.5 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo SB2 Type1 4 - 354 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3MPAA 2.1 Inactive DFGin‑BLBminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 5 - 352 0 None D168G Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3OBGA 2.8 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 5 - 352 0 None F169G Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3GCPA 2.25 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn SB2 Type1 4 - 352 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3ZS5A 1.6 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno SB2 Type1 2 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5AR4A 2.7 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn SB2 Type1 5 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5AR4B 2.7 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno SB2 Type1 6 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
CMGC MPK10 Q4QHJ8_LEIMA 3UIBA 2.65 Inactive DFGin‑BLAplus in-in none-out nonTYR APEdihe_aaoni APEdist_nooo SB2 Type1 7 - 359 0 None None Putative mitogen-activated protein kinase Leishmania major
CMGC MAPK14 MK14_MOUSE 8ACMAAA 2.14 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn SB2 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8ACOAAA 2.65 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 2EWAA 2.1 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 5 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus

Ligand: SB2

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 2 50.0% 8ACOAAA
DFGin BLAplus 1 25.0% 3UIBA
DFGin BLBplus 1 25.0% 8ACMAAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC MPK10 Q4QHJ8_LEIMA 3UIBA 2.65 Inactive DFGin‑BLAplus in-in none-out nonTYR APEdihe_aaoni APEdist_nooo SB2 Type1 7 - 359 0 None None Putative mitogen-activated protein kinase Leishmania major
CMGC MAPK14 MK14_MOUSE 8ACMAAA 2.14 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn SB2 Type1 4 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 8ACOAAA 2.65 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 4 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 2EWAA 2.1 Inactive DFGin‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn SB2 Type1 5 - 354 0 None None Mitogen-activated protein kinase 14 Mus musculus