Ligand: IRE (Gefitinib)

Total number of chains: 11
Active chains: 1
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 45.5% 4WKQA
DFGin ABAminus 3 27.3% 5Y7ZA
DFGinter None 2 18.2% 9D5HA
DFGin BLBtrans 1 9.1% 4I22A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER GAK GAK_HUMAN 5Y7ZA O14976 25 335 1311.0 IRE:60401 Type1 Inactive DFGin 6.1831 14.3017 ABAminus -120.31, -65.73 -84.03, 133.07 -132.73, 38.63 297.55, 94.83 -80.73, -23.71 in-in in 9.3299 Saltbr-in 2.6528 HRD-in -76.12, -47.1 64.19, -3.41 in-in-in SNCiii in-in ActLoopNT-in 2.6933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.58, 12.1 APE9-dihe-na -127.21, 155.97 APE8-dihe-in -88.88, 126.92 APE8-rot-in 301.28 APE67-dihe-in -75.82, -11.44 -39.58, -53.85 APE12-dist-in 11.6752 APE11-dist-in 8.7406 APE10-dist-in 4.1646 APE9-dist-in 4.1456 None None None XRAY 2.804 0.235 0.288 A 313.0 311.0 0 40 40 0 [[40, 313]] 1.0 5y7z OTHER_GAK_HUMAN CAMK 4e-44 157.2 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 5Y7ZB O14976 25 335 1311.0 IRE:60401 Type1 Inactive DFGin 6.185 14.3005 ABAminus -126.63, -59.42 -85.24, 119.57 -121.34, 32.24 292.7, 91.36 -76.51, -21.75 in-in in 8.9976 Saltbr-in 3.3359 HRD-in -76.77, -44.95 63.95, -6.3 in-in-in SNCiii in-in ActLoopNT-in 2.7625 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.15, 9.34 APE9-dihe-na -125.96, 148.71 APE8-dihe-in -79.22, 127.62 APE8-rot-in 300.16 APE67-dihe-in -76.26, -13.67 -39.68, -52.24 APE12-dist-in 11.7706 APE11-dist-in 8.7646 APE10-dist-in 4.2306 APE9-dist-in 4.0018 None None None XRAY 2.804 0.235 0.288 B 313.0 311.0 0 40 40 0 [[40, 313]] 1.0 5y7z OTHER_GAK_HUMAN CAMK 4e-44 157.2 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 5Y80A O14976 25 332 1311.0 IRE:60401,IRE:60402 Type1,Allosteric Inactive DFGin 6.2834 14.5159 ABAminus -119.77, -54.31 -90.82, 110.26 -111.11, 18.56 296.38, 94.44 -67.28, -25.31 in-in in 8.8583 Saltbr-in 3.281 HRD-in -69.89, -47.62 68.73, -10.18 in-in-out SNCiio in-out ActLoopNT-in 2.8846 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -114.53, 10.66 APE9-dihe-na -135.16, 171.64 APE8-dihe-in -123.07, 133.96 APE8-rot-in 293.66 APE67-dihe-in -69.42, -14.72 -40.65, -51.06 APE12-dist-out 14.946 APE11-dist-in 13.2539 APE10-dist-out 8.0563 APE9-dist-out 7.4733 None None None XRAY 2.5 0.232 0.282 A 313.0 305.0 3 40 40 0 [[40, 313]] 1.0 5y80 OTHER_GAK_HUMAN CAMK 4e-44 157.2 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
TKL ILK ILK_HUMAN 9D5HA Q13418 182 452 452.0 IRE:701 Type1 Pseudo DFGinter 8.1643 7.4553 None -85.0, 107.56 -70.5, -21.19 -67.61, -12.48 999.0, 999.0 -96.85, 13.46 out-out out 14.1375 Saltbr-out 13.1054 HRD-out 65.35, 60.25 -109.45, 119.86 out-out-out SNCooo out-out ActLoopNT-out 5.9108 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -110.76, 118.05 APE9-dihe-na -102.65, -7.28 APE8-dihe-in -135.36, 55.79 APE8-rot-none 999.0 APE67-dihe-in -64.5, -21.08 -63.95, -18.26 APE12-dist-out 14.9881 APE11-dist-out 14.039 APE10-dist-out 13.2356 APE9-dist-out 12.7235 C346S,R371Q,C422S None None XRAY 1.5 0.197 0.224 A 271.0 271.0 0 23 23 0 [[192, 448]] 1.0 9d5h TKL_ILK_HUMAN TKL 1.2e-62 217.9 3.0 267.0 265.0 336 337 338 340 342 220 238 242 316 318 317 319.0 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5EA Q13418 182 452 452.0 IRE:701,IRE:702 Type1,Type1 Pseudo DFGinter 8.0173 7.5238 None -89.37, 112.35 -72.14, -19.5 -70.86, -12.91 999.0, 999.0 -92.65, 14.01 out-out out 14.0573 Saltbr-out 13.1421 HRD-out -82.68, 123.44 -98.83, 148.34 out-out-out SNCooo out-out ActLoopNT-out 6.6389 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -111.62, 119.46 APE9-dihe-na -104.32, -7.67 APE8-dihe-in -135.99, 56.58 APE8-rot-none 999.0 APE67-dihe-in -63.74, -21.2 -65.26, -17.82 APE12-dist-out 14.8569 APE11-dist-in 13.8076 APE10-dist-out 12.9222 APE9-dist-out 11.8853 C346S,C422S None None XRAY 1.5 0.188 0.21 A 271.0 271.0 0 23 23 0 [[192, 448]] 1.0 9d5e TKL_ILK_HUMAN TKL 1.5e-62 217.5 3.0 267.0 265.0 336 337 338 340 342 220 238 242 316 318 317 319.0 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TYR EGFR EGFR_HUMAN 3UG2A P00533 697 1018 1210.0 IRE:1 Type1 Inactive DFGin 6.1278 16.2971 BLAminus -131.79, -168.85 59.62, 80.02 -93.0, 13.81 280.85, 97.63 -52.25, -28.71 in-out in 9.318 Saltbr-out 4.9416 HRD-in -79.26, -48.84 71.4, -5.34 out-in-in SNCoii in-in ActLoopNT-in 2.9118 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.39, 125.11 APE9-dihe-in -140.0, 141.56 APE8-dihe-in -80.99, 105.31 APE8-rot-na 37.43 APE67-dihe-in -66.78, -11.55 -70.88, -39.23 APE12-dist-na 11.8436 APE11-dist-na 9.721 APE10-dist-na 10.8584 APE9-dist-in 6.7091 G719S,T790M None None XRAY 2.5 0.19 0.249 A 334.0 299.0 8 30 30 0 [[712, 970]] 1.0 3ug2 TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITYA P00533 697 1019 1210.0 IRE:2020 Type1 None DFGin 5.7094 14.3466 BLAminus -166.22, -170.95 51.79, 94.03 -111.38, 9.95 304.52, 88.76 -48.13, -2.84 in-in in 8.0797 Saltbr-in 2.8311 HRD-in -75.89, -42.81 70.47, -11.39 in-in-none SNCiin in-none ActLoopNT-in 2.6407 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.72 APE8-dihe-in -87.66, 98.01 APE8-rot-na 34.48 APE67-dihe-in -68.44, -18.24 -69.59, -44.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.612 None None None XRAY 3.42 0.216 0.26 A 327.0 300.0 10 30 20 10 [[712, 970]] 1.0 2ity TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4WKQA P00533 696 1020 1210.0 IRE:61101 Type1 Active DFGin 5.8701 14.2698 BLAminus -136.93, -167.98 56.09, 82.01 -98.49, 20.74 290.51, 104.81 -58.21, -26.99 in-in in 8.4962 Saltbr-in 2.7769 HRD-in -72.77, -46.24 69.32, 1.48 in-in-in SNCiii in-in ActLoopNT-in 2.8502 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.97, 133.87 APE9-dihe-in -143.86, 136.85 APE8-dihe-in -65.0, 99.96 APE8-rot-na 331.29 APE67-dihe-in -71.38, -8.88 -57.65, -38.22 APE12-dist-na 12.229 APE11-dist-na 9.7408 APE10-dist-na 10.1356 APE9-dist-in 6.1476 None None CSX797 XRAY 1.85 0.196 0.225 A 330.0 295.0 8 30 30 0 [[712, 970]] 1.0 4wkq TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITOA P00533 696 1019 1210.0 IRE:2020 Type1 None DFGin 5.7483 14.1407 BLAminus -140.08, -168.63 58.3, 91.81 -104.54, 8.97 300.44, 102.41 -49.01, 0.84 in-in in 7.815 Saltbr-in 3.1613 HRD-in -92.02, -52.4 73.42, 24.83 in-in-none SNCiin in-none ActLoopNT-in 2.6906 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.39 APE8-dihe-in -85.12, 86.77 APE8-rot-na 30.96 APE67-dihe-in -73.18, -3.24 -69.84, -38.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4045 G719S None None XRAY 3.25 0.197 0.266 A 327.0 303.0 9 30 21 9 [[712, 970]] 1.0 2ito TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITZA P00533 697 1020 1210.0 IRE:2021 Type1 Inactive DFGin 5.7368 14.2306 BLAminus -131.03, -170.43 64.99, 76.02 -93.07, 24.13 302.2, 98.1 -48.52, -35.04 in-out in 8.129 Saltbr-out 3.6343 HRD-in -66.91, -39.96 62.5, 6.79 out-in-none SNCoin in-none ActLoopNT-in 2.6911 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.03 APE8-dihe-in -83.03, 97.62 APE8-rot-na 33.89 APE67-dihe-in -61.76, -16.39 -73.06, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3886 L858R None None XRAY 2.8 0.205 0.255 A 327.0 303.0 10 30 20 10 [[712, 970]] 1.0 2itz TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4I22A P00533 700 1014 1210.0 IRE:9001 Type1 Inactive DFGin 5.4627 16.4716 BLBtrans -123.06, -178.62 68.31, 18.86 -65.27, 136.35 169.35, 71.91 94.28, -11.28 out-out out 13.657 Saltbr-out 12.1766 HRD-in -84.17, -49.73 82.39, -10.75 out-out-out SNCooo out-out ActLoopNT-out 7.1046 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.61 APE8-dihe-in -75.03, 69.55 APE8-rot-na 29.55 APE67-dihe-in -78.29, -2.11 -50.24, -41.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.297 T790M,L858R,V948R None None XRAY 1.71 0.198 0.224 A 329.0 297.0 18 30 17 13 [[712, 970]] 1.0 4i22 TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: IRE (Gefitinib)

Total number of chains: 11
Active chains: 1
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 45.5% 4WKQA
DFGin ABAminus 3 27.3% 5Y7ZA
DFGinter None 2 18.2% 9D5HA
DFGin BLBtrans 1 9.1% 4I22A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER GAK GAK_HUMAN 5Y7ZA O14976 25 335 1311.0 IRE:60401 Type1 Inactive DFGin 6.1831 14.3017 ABAminus -120.31, -65.73 -84.03, 133.07 -132.73, 38.63 297.55, 94.83 -80.73, -23.71 in-in in 9.3299 Saltbr-in 2.6528 HRD-in -76.12, -47.1 64.19, -3.41 in-in-in SNCiii in-in ActLoopNT-in 2.6933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.58, 12.1 APE9-dihe-na -127.21, 155.97 APE8-dihe-in -88.88, 126.92 APE8-rot-in 301.28 APE67-dihe-in -75.82, -11.44 -39.58, -53.85 APE12-dist-in 11.6752 APE11-dist-in 8.7406 APE10-dist-in 4.1646 APE9-dist-in 4.1456 None None None XRAY 2.804 0.235 0.288 A 313.0 311.0 0 40 40 0 [[40, 313]] 1.0 5y7z Homo sapiens OTHER_GAK_HUMAN CAMK 4e-44 157.2 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 5Y7ZB O14976 25 335 1311.0 IRE:60401 Type1 Inactive DFGin 6.185 14.3005 ABAminus -126.63, -59.42 -85.24, 119.57 -121.34, 32.24 292.7, 91.36 -76.51, -21.75 in-in in 8.9976 Saltbr-in 3.3359 HRD-in -76.77, -44.95 63.95, -6.3 in-in-in SNCiii in-in ActLoopNT-in 2.7625 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.15, 9.34 APE9-dihe-na -125.96, 148.71 APE8-dihe-in -79.22, 127.62 APE8-rot-in 300.16 APE67-dihe-in -76.26, -13.67 -39.68, -52.24 APE12-dist-in 11.7706 APE11-dist-in 8.7646 APE10-dist-in 4.2306 APE9-dist-in 4.0018 None None None XRAY 2.804 0.235 0.288 B 313.0 311.0 0 40 40 0 [[40, 313]] 1.0 5y7z Homo sapiens OTHER_GAK_HUMAN CAMK 4e-44 157.2 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 5Y80A O14976 25 332 1311.0 IRE:60401,IRE:60402 Type1,Allosteric Inactive DFGin 6.2834 14.5159 ABAminus -119.77, -54.31 -90.82, 110.26 -111.11, 18.56 296.38, 94.44 -67.28, -25.31 in-in in 8.8583 Saltbr-in 3.281 HRD-in -69.89, -47.62 68.73, -10.18 in-in-out SNCiio in-out ActLoopNT-in 2.8846 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -114.53, 10.66 APE9-dihe-na -135.16, 171.64 APE8-dihe-in -123.07, 133.96 APE8-rot-in 293.66 APE67-dihe-in -69.42, -14.72 -40.65, -51.06 APE12-dist-out 14.946 APE11-dist-in 13.2539 APE10-dist-out 8.0563 APE9-dist-out 7.4733 None None None XRAY 2.5 0.232 0.282 A 313.0 305.0 3 40 40 0 [[40, 313]] 1.0 5y80 Homo sapiens OTHER_GAK_HUMAN CAMK 4e-44 157.2 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
TKL ILK ILK_HUMAN 9D5HA Q13418 182 452 452.0 IRE:701 Type1 Pseudo DFGinter 8.1643 7.4553 None -85.0, 107.56 -70.5, -21.19 -67.61, -12.48 999.0, 999.0 -96.85, 13.46 out-out out 14.1375 Saltbr-out 13.1054 HRD-out 65.35, 60.25 -109.45, 119.86 out-out-out SNCooo out-out ActLoopNT-out 5.9108 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -110.76, 118.05 APE9-dihe-na -102.65, -7.28 APE8-dihe-in -135.36, 55.79 APE8-rot-none 999.0 APE67-dihe-in -64.5, -21.08 -63.95, -18.26 APE12-dist-out 14.9881 APE11-dist-out 14.039 APE10-dist-out 13.2356 APE9-dist-out 12.7235 C346S,R371Q,C422S None None XRAY 1.5 0.197 0.224 A 271.0 271.0 0 23 23 0 [[192, 448]] 1.0 9d5h Homo sapiens TKL_ILK_HUMAN TKL 1.2e-62 217.9 3.0 267.0 265.0 336 337 338 340 342 220 238 242 316 318 317 319.0 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5EA Q13418 182 452 452.0 IRE:701,IRE:702 Type1,Type1 Pseudo DFGinter 8.0173 7.5238 None -89.37, 112.35 -72.14, -19.5 -70.86, -12.91 999.0, 999.0 -92.65, 14.01 out-out out 14.0573 Saltbr-out 13.1421 HRD-out -82.68, 123.44 -98.83, 148.34 out-out-out SNCooo out-out ActLoopNT-out 6.6389 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -111.62, 119.46 APE9-dihe-na -104.32, -7.67 APE8-dihe-in -135.99, 56.58 APE8-rot-none 999.0 APE67-dihe-in -63.74, -21.2 -65.26, -17.82 APE12-dist-out 14.8569 APE11-dist-in 13.8076 APE10-dist-out 12.9222 APE9-dist-out 11.8853 C346S,C422S None None XRAY 1.5 0.188 0.21 A 271.0 271.0 0 23 23 0 [[192, 448]] 1.0 9d5e Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3.0 267.0 265.0 336 337 338 340 342 220 238 242 316 318 317 319.0 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TYR EGFR EGFR_HUMAN 3UG2A P00533 697 1018 1210.0 IRE:1 Type1 Inactive DFGin 6.1278 16.2971 BLAminus -131.79, -168.85 59.62, 80.02 -93.0, 13.81 280.85, 97.63 -52.25, -28.71 in-out in 9.318 Saltbr-out 4.9416 HRD-in -79.26, -48.84 71.4, -5.34 out-in-in SNCoii in-in ActLoopNT-in 2.9118 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.39, 125.11 APE9-dihe-in -140.0, 141.56 APE8-dihe-in -80.99, 105.31 APE8-rot-na 37.43 APE67-dihe-in -66.78, -11.55 -70.88, -39.23 APE12-dist-na 11.8436 APE11-dist-na 9.721 APE10-dist-na 10.8584 APE9-dist-in 6.7091 G719S,T790M None None XRAY 2.5 0.19 0.249 A 334.0 299.0 8 30 30 0 [[712, 970]] 1.0 3ug2 Homo sapiens TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITYA P00533 697 1019 1210.0 IRE:2020 Type1 None DFGin 5.7094 14.3466 BLAminus -166.22, -170.95 51.79, 94.03 -111.38, 9.95 304.52, 88.76 -48.13, -2.84 in-in in 8.0797 Saltbr-in 2.8311 HRD-in -75.89, -42.81 70.47, -11.39 in-in-none SNCiin in-none ActLoopNT-in 2.6407 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.72 APE8-dihe-in -87.66, 98.01 APE8-rot-na 34.48 APE67-dihe-in -68.44, -18.24 -69.59, -44.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.612 None None None XRAY 3.42 0.216 0.26 A 327.0 300.0 10 30 20 10 [[712, 970]] 1.0 2ity Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4WKQA P00533 696 1020 1210.0 IRE:61101 Type1 Active DFGin 5.8701 14.2698 BLAminus -136.93, -167.98 56.09, 82.01 -98.49, 20.74 290.51, 104.81 -58.21, -26.99 in-in in 8.4962 Saltbr-in 2.7769 HRD-in -72.77, -46.24 69.32, 1.48 in-in-in SNCiii in-in ActLoopNT-in 2.8502 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.97, 133.87 APE9-dihe-in -143.86, 136.85 APE8-dihe-in -65.0, 99.96 APE8-rot-na 331.29 APE67-dihe-in -71.38, -8.88 -57.65, -38.22 APE12-dist-na 12.229 APE11-dist-na 9.7408 APE10-dist-na 10.1356 APE9-dist-in 6.1476 None None CSX797 XRAY 1.85 0.196 0.225 A 330.0 295.0 8 30 30 0 [[712, 970]] 1.0 4wkq Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITOA P00533 696 1019 1210.0 IRE:2020 Type1 None DFGin 5.7483 14.1407 BLAminus -140.08, -168.63 58.3, 91.81 -104.54, 8.97 300.44, 102.41 -49.01, 0.84 in-in in 7.815 Saltbr-in 3.1613 HRD-in -92.02, -52.4 73.42, 24.83 in-in-none SNCiin in-none ActLoopNT-in 2.6906 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.39 APE8-dihe-in -85.12, 86.77 APE8-rot-na 30.96 APE67-dihe-in -73.18, -3.24 -69.84, -38.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4045 G719S None None XRAY 3.25 0.197 0.266 A 327.0 303.0 9 30 21 9 [[712, 970]] 1.0 2ito Homo sapiens TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITZA P00533 697 1020 1210.0 IRE:2021 Type1 Inactive DFGin 5.7368 14.2306 BLAminus -131.03, -170.43 64.99, 76.02 -93.07, 24.13 302.2, 98.1 -48.52, -35.04 in-out in 8.129 Saltbr-out 3.6343 HRD-in -66.91, -39.96 62.5, 6.79 out-in-none SNCoin in-none ActLoopNT-in 2.6911 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 109.03 APE8-dihe-in -83.03, 97.62 APE8-rot-na 33.89 APE67-dihe-in -61.76, -16.39 -73.06, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3886 L858R None None XRAY 2.8 0.205 0.255 A 327.0 303.0 10 30 20 10 [[712, 970]] 1.0 2itz Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4I22A P00533 700 1014 1210.0 IRE:9001 Type1 Inactive DFGin 5.4627 16.4716 BLBtrans -123.06, -178.62 68.31, 18.86 -65.27, 136.35 169.35, 71.91 94.28, -11.28 out-out out 13.657 Saltbr-out 12.1766 HRD-in -84.17, -49.73 82.39, -10.75 out-out-out SNCooo out-out ActLoopNT-out 7.1046 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.61 APE8-dihe-in -75.03, 69.55 APE8-rot-na 29.55 APE67-dihe-in -78.29, -2.11 -50.24, -41.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.297 T790M,L858R,V948R None None XRAY 1.71 0.198 0.224 A 329.0 297.0 18 30 17 13 [[712, 970]] 1.0 4i22 Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: IRE (Gefitinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name