Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OTHER | GAK | GAK_HUMAN | 5Y7ZA | O14976 | 25 | 335 | 1311.0 | IRE:60401 | Type1 | Inactive | DFGin | 6.183 | 14.302 | ABAminus | -120.31, -65.73 | -84.03, 133.07 | -132.73, 38.63 | 297.55, 94.83 | -80.73, -23.71 | in-in | in | 9.33 | Saltbr-in | 2.653 | HRD-in | -76.12, -47.1 | 64.19, -3.41 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.693 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -90.58, 12.1 | APE9-dihe-na | -127.21, 155.97 | APE8-dihe-in | -88.88, 126.92 | APE8-rot-in | 301.28 | APE67-dihe-in | -75.82, -11.44 | -39.58, -53.85 | APE12-dist-in | 11.675 | APE11-dist-in | 8.741 | APE10-dist-in | 4.165 | APE9-dist-in | 4.146 | None | None | None | XRAY | 2.804 | 0.235 | 0.288 | A | 313 | 311 | 0 | 0 | 0 | 0 | [[40, 313]] | 1.0 | 5y7z | OTHER_GAK_HUMAN | CAMK | 4e-44 | 157.2 | 3 | 252 | 250 | 190 | 191 | 192 | 194 | 196 | 69 | 85 | 89 | 170 | 172 | 171 | 173 | 245 | 230 | 225 | 224 | 223 | 222 | 221 | 220 | 219 | 124 | Cyclin-G-associated kinase |
| OTHER | GAK | GAK_HUMAN | 5Y7ZB | O14976 | 25 | 335 | 1311.0 | IRE:60401 | Type1 | Inactive | DFGin | 6.185 | 14.3 | ABAminus | -126.63, -59.42 | -85.24, 119.57 | -121.34, 32.24 | 292.7, 91.36 | -76.51, -21.75 | in-in | in | 8.998 | Saltbr-in | 3.336 | HRD-in | -76.77, -44.95 | 63.95, -6.3 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.763 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -88.15, 9.34 | APE9-dihe-na | -125.96, 148.71 | APE8-dihe-in | -79.22, 127.62 | APE8-rot-in | 300.16 | APE67-dihe-in | -76.26, -13.67 | -39.68, -52.24 | APE12-dist-in | 11.771 | APE11-dist-in | 8.765 | APE10-dist-in | 4.231 | APE9-dist-in | 4.002 | None | None | None | XRAY | 2.804 | 0.235 | 0.288 | B | 313 | 311 | 0 | 0 | 0 | 0 | [[40, 313]] | 1.0 | 5y7z | OTHER_GAK_HUMAN | CAMK | 4e-44 | 157.2 | 3 | 252 | 250 | 190 | 191 | 192 | 194 | 196 | 69 | 85 | 89 | 170 | 172 | 171 | 173 | 245 | 230 | 225 | 224 | 223 | 222 | 221 | 220 | 219 | 124 | Cyclin-G-associated kinase |
| OTHER | GAK | GAK_HUMAN | 5Y80A | O14976 | 25 | 332 | 1311.0 | IRE:60401,IRE:60402 | Type1,Allosteric | Inactive | DFGin | 6.283 | 14.516 | ABAminus | -119.77, -54.31 | -90.82, 110.26 | -111.11, 18.56 | 296.38, 94.44 | -67.28, -25.31 | in-in | in | 8.858 | Saltbr-in | 3.281 | HRD-in | -69.89, -47.62 | 68.73, -10.18 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.885 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_oioo | APE10-dihe-na | -114.53, 10.66 | APE9-dihe-na | -135.16, 171.64 | APE8-dihe-in | -123.07, 133.96 | APE8-rot-in | 293.66 | APE67-dihe-in | -69.42, -14.72 | -40.65, -51.06 | APE12-dist-out | 14.946 | APE11-dist-in | 13.254 | APE10-dist-out | 8.056 | APE9-dist-out | 7.473 | None | None | None | XRAY | 2.5 | 0.232 | 0.282 | A | 313 | 305 | 3 | 0 | 0 | 0 | [[40, 313]] | 1.0 | 5y80 | OTHER_GAK_HUMAN | CAMK | 4e-44 | 157.2 | 3 | 252 | 250 | 190 | 191 | 192 | 194 | 196 | 69 | 85 | 89 | 170 | 172 | 171 | 173 | 245 | 230 | 225 | 224 | 223 | 222 | 221 | 220 | 219 | 124 | Cyclin-G-associated kinase |
| TKL | ILK | ILK_HUMAN | 9D5HA | Q13418 | 182 | 452 | 452.0 | IRE:701 | Type1 | Pseudo | DFGinter | 8.164 | 7.455 | None | -85.0, 107.56 | -70.5, -21.19 | -67.61, -12.48 | 999.0, 999.0 | -96.85, 13.46 | out-out | out | 14.137 | Saltbr-out | 13.105 | HRD-out | 65.35, 60.25 | -109.45, 119.86 | out-out-out | SNCooo | out-out | ActLoopNT-out | 5.911 | ActLoopCT-out | nonTYR | APEdihe_aaini | APEdist_oooo | APE10-dihe-na | -110.76, 118.05 | APE9-dihe-na | -102.65, -7.28 | APE8-dihe-in | -135.36, 55.79 | APE8-rot-none | 999.0 | APE67-dihe-in | -64.5, -21.08 | -63.95, -18.26 | APE12-dist-out | 14.988 | APE11-dist-out | 14.039 | APE10-dist-out | 13.236 | APE9-dist-out | 12.723 | C346S,R371Q,C422S | None | None | XRAY | 1.5 | 0.197 | 0.224 | A | 271 | 271 | 0 | 0 | 0 | 0 | [[192, 448]] | 1.0 | 9d5h | TKL_ILK_HUMAN | TKL | 1.2e-62 | 217.9 | 3 | 267 | 265 | 336 | 337 | 338 | 340 | 342 | 220 | 238 | 242 | 316 | 318 | 317 | 319 | 374 | 359 | 354 | 353 | 352 | 351 | 350 | 349 | 348 | 270 | Scaffold protein ILK |
| TKL | ILK | ILK_HUMAN | 9D5EA | Q13418 | 182 | 452 | 452.0 | IRE:701,IRE:702 | Type1,Type1 | Pseudo | DFGinter | 8.017 | 7.524 | None | -89.37, 112.35 | -72.14, -19.5 | -70.86, -12.91 | 999.0, 999.0 | -92.65, 14.01 | out-out | out | 14.057 | Saltbr-out | 13.142 | HRD-out | -82.68, 123.44 | -98.83, 148.34 | out-out-out | SNCooo | out-out | ActLoopNT-out | 6.639 | ActLoopCT-out | nonTYR | APEdihe_aaini | APEdist_oioo | APE10-dihe-na | -111.62, 119.46 | APE9-dihe-na | -104.32, -7.67 | APE8-dihe-in | -135.99, 56.58 | APE8-rot-none | 999.0 | APE67-dihe-in | -63.74, -21.2 | -65.26, -17.82 | APE12-dist-out | 14.857 | APE11-dist-in | 13.808 | APE10-dist-out | 12.922 | APE9-dist-out | 11.885 | C346S,C422S | None | None | XRAY | 1.5 | 0.188 | 0.21 | A | 271 | 271 | 0 | 0 | 0 | 0 | [[192, 448]] | 1.0 | 9d5e | TKL_ILK_HUMAN | TKL | 1.5e-62 | 217.5 | 3 | 267 | 265 | 336 | 337 | 338 | 340 | 342 | 220 | 238 | 242 | 316 | 318 | 317 | 319 | 374 | 359 | 354 | 353 | 352 | 351 | 350 | 349 | 348 | 270 | Scaffold protein ILK |
| TYR | EGFR | EGFR_HUMAN | 3UG2A | P00533 | 697 | 1018 | 1210.0 | IRE:1 | Type1 | Inactive | DFGin | 6.128 | 16.297 | BLAminus | -131.79, -168.85 | 59.62, 80.02 | -93.0, 13.81 | 280.85, 97.63 | -52.25, -28.71 | in-out | in | 9.318 | Saltbr-out | 4.942 | HRD-in | -79.26, -48.84 | 71.4, -5.34 | out-in-in | SNCoii | in-in | ActLoopNT-in | 2.912 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -71.39, 125.11 | APE9-dihe-in | -140.0, 141.56 | APE8-dihe-in | -80.99, 105.31 | APE8-rot-na | 37.43 | APE67-dihe-in | -66.78, -11.55 | -70.88, -39.23 | APE12-dist-na | 11.844 | APE11-dist-na | 9.721 | APE10-dist-na | 10.858 | APE9-dist-in | 6.709 | G719S,T790M | None | None | XRAY | 2.5 | 0.19 | 0.249 | A | 334 | 299 | 8 | 0 | 0 | 0 | [[712, 970]] | 1.0 | 3ug2 | TYR_EGFR_HUMAN | TYR | 7.9e-87 | 296.9 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 2ITYA | P00533 | 697 | 1019 | 1210.0 | IRE:2020 | Type1 | None | DFGin | 5.709 | 14.347 | BLAminus | -166.22, -170.95 | 51.79, 94.03 | -111.38, 9.95 | 304.52, 88.76 | -48.13, -2.84 | in-in | in | 8.08 | Saltbr-in | 2.831 | HRD-in | -75.89, -42.81 | 70.47, -11.39 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.641 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 109.72 | APE8-dihe-in | -87.66, 98.01 | APE8-rot-na | 34.48 | APE67-dihe-in | -68.44, -18.24 | -69.59, -44.25 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.612 | None | None | None | XRAY | 3.42 | 0.216 | 0.26 | A | 327 | 300 | 10 | 0 | 0 | 10 | [[712, 970]] | 1.0 | 2ity | TYR_EGFR_HUMAN | TYR | 1e-87 | 299.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4WKQA | P00533 | 696 | 1020 | 1210.0 | IRE:61101 | Type1 | Active | DFGin | 5.87 | 14.27 | BLAminus | -136.93, -167.98 | 56.09, 82.01 | -98.49, 20.74 | 290.51, 104.81 | -58.21, -26.99 | in-in | in | 8.496 | Saltbr-in | 2.777 | HRD-in | -72.77, -46.24 | 69.32, 1.48 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.85 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -61.97, 133.87 | APE9-dihe-in | -143.86, 136.85 | APE8-dihe-in | -65.0, 99.96 | APE8-rot-na | 331.29 | APE67-dihe-in | -71.38, -8.88 | -57.65, -38.22 | APE12-dist-na | 12.229 | APE11-dist-na | 9.741 | APE10-dist-na | 10.136 | APE9-dist-in | 6.148 | None | None | CSX797 | XRAY | 1.85 | 0.196 | 0.225 | A | 330 | 295 | 8 | 0 | 0 | 0 | [[712, 970]] | 1.0 | 4wkq | TYR_EGFR_HUMAN | TYR | 1.1e-87 | 299.7 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 2ITOA | P00533 | 696 | 1019 | 1210.0 | IRE:2020 | Type1 | None | DFGin | 5.748 | 14.141 | BLAminus | -140.08, -168.63 | 58.3, 91.81 | -104.54, 8.97 | 300.44, 102.41 | -49.01, 0.84 | in-in | in | 7.815 | Saltbr-in | 3.161 | HRD-in | -92.02, -52.4 | 73.42, 24.83 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.691 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 104.39 | APE8-dihe-in | -85.12, 86.77 | APE8-rot-na | 30.96 | APE67-dihe-in | -73.18, -3.24 | -69.84, -38.71 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.404 | G719S | None | None | XRAY | 3.25 | 0.197 | 0.266 | A | 327 | 303 | 9 | 0 | 0 | 9 | [[712, 970]] | 1.0 | 2ito | TYR_EGFR_HUMAN | TYR | 9.6e-87 | 296.6 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 2ITZA | P00533 | 697 | 1020 | 1210.0 | IRE:2021 | Type1 | Inactive | DFGin | 5.737 | 14.231 | BLAminus | -131.03, -170.43 | 64.99, 76.02 | -93.07, 24.13 | 302.2, 98.1 | -48.52, -35.04 | in-out | in | 8.129 | Saltbr-out | 3.634 | HRD-in | -66.91, -39.96 | 62.5, 6.79 | out-in-none | SNCoin | in-none | ActLoopNT-in | 2.691 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 109.03 | APE8-dihe-in | -83.03, 97.62 | APE8-rot-na | 33.89 | APE67-dihe-in | -61.76, -16.39 | -73.06, -45.07 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.389 | L858R | None | None | XRAY | 2.8 | 0.205 | 0.255 | A | 327 | 303 | 10 | 0 | 0 | 10 | [[712, 970]] | 1.0 | 2itz | TYR_EGFR_HUMAN | TYR | 1.1e-86 | 296.4 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4I22A | P00533 | 700 | 1014 | 1210.0 | IRE:9001 | Type1 | Inactive | DFGin | 5.463 | 16.472 | BLBtrans | -123.06, -178.62 | 68.31, 18.86 | -65.27, 136.35 | 169.35, 71.91 | 94.28, -11.28 | out-out | out | 13.657 | Saltbr-out | 12.177 | HRD-in | -84.17, -49.73 | 82.39, -10.75 | out-out-out | SNCooo | out-out | ActLoopNT-out | 7.105 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 130.61 | APE8-dihe-in | -75.03, 69.55 | APE8-rot-na | 29.55 | APE67-dihe-in | -78.29, -2.11 | -50.24, -41.22 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.297 | T790M,L858R,V948R | None | None | XRAY | 1.71 | 0.198 | 0.224 | A | 329 | 297 | 18 | 0 | 0 | 13 | [[712, 970]] | 1.0 | 4i22 | TYR_EGFR_HUMAN | TYR | 6.4e-87 | 297.2 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OTHER | GAK | GAK_HUMAN | 5Y7ZA | O14976 | 25 | 335 | 1311.0 | IRE:60401 | Type1 | Inactive | DFGin | 6.183 | 14.302 | ABAminus | -120.31, -65.73 | -84.03, 133.07 | -132.73, 38.63 | 297.55, 94.83 | -80.73, -23.71 | in-in | in | 9.33 | Saltbr-in | 2.653 | HRD-in | -76.12, -47.1 | 64.19, -3.41 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.693 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -90.58, 12.1 | APE9-dihe-na | -127.21, 155.97 | APE8-dihe-in | -88.88, 126.92 | APE8-rot-in | 301.28 | APE67-dihe-in | -75.82, -11.44 | -39.58, -53.85 | APE12-dist-in | 11.675 | APE11-dist-in | 8.741 | APE10-dist-in | 4.165 | APE9-dist-in | 4.146 | None | None | None | XRAY | 2.804 | 0.235 | 0.288 | A | 313 | 311 | 0 | 0 | 0 | 0 | [[40, 313]] | 1.0 | 5y7z | Homo sapiens | OTHER_GAK_HUMAN | CAMK | 4e-44 | 157.2 | 3 | 252 | 250 | 190 | 191 | 192 | 194 | 196 | 69 | 85 | 89 | 170 | 172 | 171 | 173 | 245 | 230 | 225 | 224 | 223 | 222 | 221 | 220 | 219 | 124 | Cyclin-G-associated kinase |
| OTHER | GAK | GAK_HUMAN | 5Y7ZB | O14976 | 25 | 335 | 1311.0 | IRE:60401 | Type1 | Inactive | DFGin | 6.185 | 14.3 | ABAminus | -126.63, -59.42 | -85.24, 119.57 | -121.34, 32.24 | 292.7, 91.36 | -76.51, -21.75 | in-in | in | 8.998 | Saltbr-in | 3.336 | HRD-in | -76.77, -44.95 | 63.95, -6.3 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.763 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -88.15, 9.34 | APE9-dihe-na | -125.96, 148.71 | APE8-dihe-in | -79.22, 127.62 | APE8-rot-in | 300.16 | APE67-dihe-in | -76.26, -13.67 | -39.68, -52.24 | APE12-dist-in | 11.771 | APE11-dist-in | 8.765 | APE10-dist-in | 4.231 | APE9-dist-in | 4.002 | None | None | None | XRAY | 2.804 | 0.235 | 0.288 | B | 313 | 311 | 0 | 0 | 0 | 0 | [[40, 313]] | 1.0 | 5y7z | Homo sapiens | OTHER_GAK_HUMAN | CAMK | 4e-44 | 157.2 | 3 | 252 | 250 | 190 | 191 | 192 | 194 | 196 | 69 | 85 | 89 | 170 | 172 | 171 | 173 | 245 | 230 | 225 | 224 | 223 | 222 | 221 | 220 | 219 | 124 | Cyclin-G-associated kinase |
| OTHER | GAK | GAK_HUMAN | 5Y80A | O14976 | 25 | 332 | 1311.0 | IRE:60401,IRE:60402 | Type1,Allosteric | Inactive | DFGin | 6.283 | 14.516 | ABAminus | -119.77, -54.31 | -90.82, 110.26 | -111.11, 18.56 | 296.38, 94.44 | -67.28, -25.31 | in-in | in | 8.858 | Saltbr-in | 3.281 | HRD-in | -69.89, -47.62 | 68.73, -10.18 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.885 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_oioo | APE10-dihe-na | -114.53, 10.66 | APE9-dihe-na | -135.16, 171.64 | APE8-dihe-in | -123.07, 133.96 | APE8-rot-in | 293.66 | APE67-dihe-in | -69.42, -14.72 | -40.65, -51.06 | APE12-dist-out | 14.946 | APE11-dist-in | 13.254 | APE10-dist-out | 8.056 | APE9-dist-out | 7.473 | None | None | None | XRAY | 2.5 | 0.232 | 0.282 | A | 313 | 305 | 3 | 0 | 0 | 0 | [[40, 313]] | 1.0 | 5y80 | Homo sapiens | OTHER_GAK_HUMAN | CAMK | 4e-44 | 157.2 | 3 | 252 | 250 | 190 | 191 | 192 | 194 | 196 | 69 | 85 | 89 | 170 | 172 | 171 | 173 | 245 | 230 | 225 | 224 | 223 | 222 | 221 | 220 | 219 | 124 | Cyclin-G-associated kinase |
| TKL | ILK | ILK_HUMAN | 9D5HA | Q13418 | 182 | 452 | 452.0 | IRE:701 | Type1 | Pseudo | DFGinter | 8.164 | 7.455 | None | -85.0, 107.56 | -70.5, -21.19 | -67.61, -12.48 | 999.0, 999.0 | -96.85, 13.46 | out-out | out | 14.137 | Saltbr-out | 13.105 | HRD-out | 65.35, 60.25 | -109.45, 119.86 | out-out-out | SNCooo | out-out | ActLoopNT-out | 5.911 | ActLoopCT-out | nonTYR | APEdihe_aaini | APEdist_oooo | APE10-dihe-na | -110.76, 118.05 | APE9-dihe-na | -102.65, -7.28 | APE8-dihe-in | -135.36, 55.79 | APE8-rot-none | 999.0 | APE67-dihe-in | -64.5, -21.08 | -63.95, -18.26 | APE12-dist-out | 14.988 | APE11-dist-out | 14.039 | APE10-dist-out | 13.236 | APE9-dist-out | 12.723 | C346S,R371Q,C422S | None | None | XRAY | 1.5 | 0.197 | 0.224 | A | 271 | 271 | 0 | 0 | 0 | 0 | [[192, 448]] | 1.0 | 9d5h | Homo sapiens | TKL_ILK_HUMAN | TKL | 1.2e-62 | 217.9 | 3 | 267 | 265 | 336 | 337 | 338 | 340 | 342 | 220 | 238 | 242 | 316 | 318 | 317 | 319 | 374 | 359 | 354 | 353 | 352 | 351 | 350 | 349 | 348 | 270 | Scaffold protein ILK |
| TKL | ILK | ILK_HUMAN | 9D5EA | Q13418 | 182 | 452 | 452.0 | IRE:701,IRE:702 | Type1,Type1 | Pseudo | DFGinter | 8.017 | 7.524 | None | -89.37, 112.35 | -72.14, -19.5 | -70.86, -12.91 | 999.0, 999.0 | -92.65, 14.01 | out-out | out | 14.057 | Saltbr-out | 13.142 | HRD-out | -82.68, 123.44 | -98.83, 148.34 | out-out-out | SNCooo | out-out | ActLoopNT-out | 6.639 | ActLoopCT-out | nonTYR | APEdihe_aaini | APEdist_oioo | APE10-dihe-na | -111.62, 119.46 | APE9-dihe-na | -104.32, -7.67 | APE8-dihe-in | -135.99, 56.58 | APE8-rot-none | 999.0 | APE67-dihe-in | -63.74, -21.2 | -65.26, -17.82 | APE12-dist-out | 14.857 | APE11-dist-in | 13.808 | APE10-dist-out | 12.922 | APE9-dist-out | 11.885 | C346S,C422S | None | None | XRAY | 1.5 | 0.188 | 0.21 | A | 271 | 271 | 0 | 0 | 0 | 0 | [[192, 448]] | 1.0 | 9d5e | Homo sapiens | TKL_ILK_HUMAN | TKL | 1.5e-62 | 217.5 | 3 | 267 | 265 | 336 | 337 | 338 | 340 | 342 | 220 | 238 | 242 | 316 | 318 | 317 | 319 | 374 | 359 | 354 | 353 | 352 | 351 | 350 | 349 | 348 | 270 | Scaffold protein ILK |
| TYR | EGFR | EGFR_HUMAN | 3UG2A | P00533 | 697 | 1018 | 1210.0 | IRE:1 | Type1 | Inactive | DFGin | 6.128 | 16.297 | BLAminus | -131.79, -168.85 | 59.62, 80.02 | -93.0, 13.81 | 280.85, 97.63 | -52.25, -28.71 | in-out | in | 9.318 | Saltbr-out | 4.942 | HRD-in | -79.26, -48.84 | 71.4, -5.34 | out-in-in | SNCoii | in-in | ActLoopNT-in | 2.912 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -71.39, 125.11 | APE9-dihe-in | -140.0, 141.56 | APE8-dihe-in | -80.99, 105.31 | APE8-rot-na | 37.43 | APE67-dihe-in | -66.78, -11.55 | -70.88, -39.23 | APE12-dist-na | 11.844 | APE11-dist-na | 9.721 | APE10-dist-na | 10.858 | APE9-dist-in | 6.709 | G719S,T790M | None | None | XRAY | 2.5 | 0.19 | 0.249 | A | 334 | 299 | 8 | 0 | 0 | 0 | [[712, 970]] | 1.0 | 3ug2 | Homo sapiens | TYR_EGFR_HUMAN | TYR | 7.9e-87 | 296.9 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 2ITYA | P00533 | 697 | 1019 | 1210.0 | IRE:2020 | Type1 | None | DFGin | 5.709 | 14.347 | BLAminus | -166.22, -170.95 | 51.79, 94.03 | -111.38, 9.95 | 304.52, 88.76 | -48.13, -2.84 | in-in | in | 8.08 | Saltbr-in | 2.831 | HRD-in | -75.89, -42.81 | 70.47, -11.39 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.641 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 109.72 | APE8-dihe-in | -87.66, 98.01 | APE8-rot-na | 34.48 | APE67-dihe-in | -68.44, -18.24 | -69.59, -44.25 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.612 | None | None | None | XRAY | 3.42 | 0.216 | 0.26 | A | 327 | 300 | 10 | 0 | 0 | 10 | [[712, 970]] | 1.0 | 2ity | Homo sapiens | TYR_EGFR_HUMAN | TYR | 1e-87 | 299.8 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4WKQA | P00533 | 696 | 1020 | 1210.0 | IRE:61101 | Type1 | Active | DFGin | 5.87 | 14.27 | BLAminus | -136.93, -167.98 | 56.09, 82.01 | -98.49, 20.74 | 290.51, 104.81 | -58.21, -26.99 | in-in | in | 8.496 | Saltbr-in | 2.777 | HRD-in | -72.77, -46.24 | 69.32, 1.48 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.85 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -61.97, 133.87 | APE9-dihe-in | -143.86, 136.85 | APE8-dihe-in | -65.0, 99.96 | APE8-rot-na | 331.29 | APE67-dihe-in | -71.38, -8.88 | -57.65, -38.22 | APE12-dist-na | 12.229 | APE11-dist-na | 9.741 | APE10-dist-na | 10.136 | APE9-dist-in | 6.148 | None | None | CSX797 | XRAY | 1.85 | 0.196 | 0.225 | A | 330 | 295 | 8 | 0 | 0 | 0 | [[712, 970]] | 1.0 | 4wkq | Homo sapiens | TYR_EGFR_HUMAN | TYR | 1.1e-87 | 299.7 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 2ITOA | P00533 | 696 | 1019 | 1210.0 | IRE:2020 | Type1 | None | DFGin | 5.748 | 14.141 | BLAminus | -140.08, -168.63 | 58.3, 91.81 | -104.54, 8.97 | 300.44, 102.41 | -49.01, 0.84 | in-in | in | 7.815 | Saltbr-in | 3.161 | HRD-in | -92.02, -52.4 | 73.42, 24.83 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.691 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 104.39 | APE8-dihe-in | -85.12, 86.77 | APE8-rot-na | 30.96 | APE67-dihe-in | -73.18, -3.24 | -69.84, -38.71 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.404 | G719S | None | None | XRAY | 3.25 | 0.197 | 0.266 | A | 327 | 303 | 9 | 0 | 0 | 9 | [[712, 970]] | 1.0 | 2ito | Homo sapiens | TYR_EGFR_HUMAN | TYR | 9.6e-87 | 296.6 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 2ITZA | P00533 | 697 | 1020 | 1210.0 | IRE:2021 | Type1 | Inactive | DFGin | 5.737 | 14.231 | BLAminus | -131.03, -170.43 | 64.99, 76.02 | -93.07, 24.13 | 302.2, 98.1 | -48.52, -35.04 | in-out | in | 8.129 | Saltbr-out | 3.634 | HRD-in | -66.91, -39.96 | 62.5, 6.79 | out-in-none | SNCoin | in-none | ActLoopNT-in | 2.691 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 109.03 | APE8-dihe-in | -83.03, 97.62 | APE8-rot-na | 33.89 | APE67-dihe-in | -61.76, -16.39 | -73.06, -45.07 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.389 | L858R | None | None | XRAY | 2.8 | 0.205 | 0.255 | A | 327 | 303 | 10 | 0 | 0 | 10 | [[712, 970]] | 1.0 | 2itz | Homo sapiens | TYR_EGFR_HUMAN | TYR | 1.1e-86 | 296.4 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4I22A | P00533 | 700 | 1014 | 1210.0 | IRE:9001 | Type1 | Inactive | DFGin | 5.463 | 16.472 | BLBtrans | -123.06, -178.62 | 68.31, 18.86 | -65.27, 136.35 | 169.35, 71.91 | 94.28, -11.28 | out-out | out | 13.657 | Saltbr-out | 12.177 | HRD-in | -84.17, -49.73 | 82.39, -10.75 | out-out-out | SNCooo | out-out | ActLoopNT-out | 7.105 | ActLoopCT-out | TYR | APEdihe_nniai | APEdist_aaao | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 130.61 | APE8-dihe-in | -75.03, 69.55 | APE8-rot-na | 29.55 | APE67-dihe-in | -78.29, -2.11 | -50.24, -41.22 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-out | 8.297 | T790M,L858R,V948R | None | None | XRAY | 1.71 | 0.198 | 0.224 | A | 329 | 297 | 18 | 0 | 0 | 13 | [[712, 970]] | 1.0 | 4i22 | Homo sapiens | TYR_EGFR_HUMAN | TYR | 6.4e-87 | 297.2 | 3 | 259 | 257 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
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