Ligand: B49 (Sunitinib, Sutent)

Total number of chains: 21
Active chains: 3
Total number of genes: 9
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 38.1% 4QMZA
DFGout BBAminus 5 23.8% 8S14A
DFGin ABAminus 2 9.5% 6NFYB
DFGin None 2 9.5% 6NG0A
DFGout None 2 9.5% 3G0EA
DFGin BLAplus 1 4.8% 3MIYB
DFGin BLBminus 1 4.8% 3TI1A
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK PHKG2 PHKG2_HUMAN 2Y7JA P15735 10 293 406.0 B49:1294 Type1 Inactive DFGin 6.665 14.816 BLAminus -136.35, -170.16 54.75, 70.88 -92.39, 20.81 284.08, 76.85 -61.83, -24.19 out-out out 10.25 Saltbr-out 4.465 HRD-in -62.79, -53.07 70.61, 18.6 out-in-in SNCoii in-in ActLoopNT-in 3.006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.94, 142.23 APE9-dihe-na 122.3, 163.86 APE8-dihe-in -75.83, 126.85 APE8-rot-in 314.78 APE67-dihe-in -61.19, -25.01 -48.83, -43.94 APE12-dist-in 8.699 APE11-dist-in 11.31 APE10-dist-in 5.755 APE9-dist-in 3.515 None None None XRAY 2.5 0.184 0.216 A 365 284 0 0 0 0 [[24, 291]] 1.0 2y7j CAMK_PHKG2_HUMAN CAMK 3.8e-87 298.0 1 256 256 170 171 172 174 176 53 77 81 150 152 151 153 215 197 192 191 190 189 188 187 186 108 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
CAMK PHKG2 PHKG2_HUMAN 2Y7JB P15735 10 293 406.0 B49:1294 Type1 Inactive DFGin 6.564 15.201 BLAminus -134.53, -168.98 53.87, 69.09 -88.65, 24.72 282.53, 76.39 -61.6, -27.15 out-out out 10.429 Saltbr-out 4.803 HRD-in -65.97, -49.45 65.68, 10.08 out-in-in SNCoii in-in ActLoopNT-in 3.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.71, 165.45 APE9-dihe-na 107.35, 176.19 APE8-dihe-in -84.88, 130.97 APE8-rot-in 310.21 APE67-dihe-in -62.86, -22.06 -48.14, -44.88 APE12-dist-in 8.415 APE11-dist-in 11.113 APE10-dist-in 5.483 APE9-dist-in 3.354 None None None XRAY 2.5 0.184 0.216 B 365 281 3 0 0 0 [[24, 291]] 1.0 2y7j CAMK_PHKG2_HUMAN CAMK 3.8e-87 298.0 1 256 256 170 171 172 174 176 53 77 81 150 152 151 153 215 197 192 191 190 189 188 187 186 108 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
CAMK PHKG2 PHKG2_HUMAN 2Y7JC P15735 10 293 406.0 B49:1294 Type1 Inactive DFGin 6.771 14.996 BLAminus -128.01, -166.61 49.58, 75.18 -93.06, 22.57 284.6, 75.8 -62.72, -24.5 out-out out 10.554 Saltbr-out 4.793 HRD-in -67.86, -49.01 71.89, 11.92 out-in-in SNCoii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.59, 158.94 APE9-dihe-na 110.48, 179.0 APE8-dihe-in -88.44, 129.7 APE8-rot-in 310.49 APE67-dihe-in -63.94, -22.15 -49.61, -43.54 APE12-dist-in 8.456 APE11-dist-in 11.047 APE10-dist-in 5.43 APE9-dist-in 3.556 None None None XRAY 2.5 0.184 0.216 C 365 284 0 0 0 0 [[24, 291]] 1.0 2y7j CAMK_PHKG2_HUMAN CAMK 3.8e-87 298.0 1 256 256 170 171 172 174 176 53 77 81 150 152 151 153 215 197 192 191 190 189 188 187 186 108 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
CAMK PHKG2 PHKG2_HUMAN 2Y7JD P15735 10 293 406.0 B49:1294 Type1 Inactive DFGin 6.641 15.224 BLAminus -131.7, -173.29 54.45, 74.24 -92.53, 24.77 283.53, 75.93 -62.64, -24.73 out-out out 10.594 Saltbr-out 4.893 HRD-in -65.75, -51.36 68.23, 9.72 out-in-in SNCoii in-in ActLoopNT-in 2.994 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.1, 164.39 APE9-dihe-na 106.84, 174.06 APE8-dihe-in -83.97, 130.15 APE8-rot-in 310.84 APE67-dihe-in -63.49, -21.75 -48.4, -43.95 APE12-dist-in 8.517 APE11-dist-in 11.197 APE10-dist-in 5.527 APE9-dist-in 3.329 None None None XRAY 2.5 0.184 0.216 D 365 281 3 0 0 0 [[24, 291]] 1.0 2y7j CAMK_PHKG2_HUMAN CAMK 3.8e-87 298.0 1 256 256 170 171 172 174 176 53 77 81 150 152 151 153 215 197 192 191 190 189 188 187 186 108 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
CMGC CDK2 CDK2_HUMAN 3TI1A P24941 1 298 298.0 B49:299 Type1 Inactive DFGin 7.489 14.948 BLBminus -138.54, 165.85 55.25, 50.84 -54.7, 138.08 282.79, 63.1 -95.42, 15.79 out-out out 16.039 Saltbr-out 14.61 HRD-in -73.91, -54.49 74.09, -22.19 out-out-out SNCooo out-out ActLoopNT-out 7.753 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -103.63, 110.78 APE9-dihe-na -67.36, 128.32 APE8-dihe-in -75.16, 126.28 APE8-rot-in 271.07 APE67-dihe-in -58.11, -32.93 -95.87, -2.85 APE12-dist-out 22.302 APE11-dist-out 17.662 APE10-dist-out 19.612 APE9-dist-out 10.928 None None None XRAY 1.99 0.205 0.262 A 298 294 4 0 0 0 [[4, 286]] 1.0 3ti1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
STE MAP4K1 M4K1_HUMAN 6NFYA Q92918 10 292 833.0 B49:69000 Type1 Inactive DFGin 5.593 14.914 ABAminus -77.99, -10.08 -165.37, 178.6 -100.73, 5.46 299.9, 89.52 78.01, -158.47 out-out out 11.415 Saltbr-out 8.806 HRD-in -67.76, -54.16 80.53, -5.66 out-out-out SNCooo out-out ActLoopNT-out 5.972 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -122.43, 132.12 APE9-dihe-na -84.67, -151.78 APE8-dihe-in -82.18, 120.44 APE8-rot-in 317.02 APE67-dihe-in -65.57, -25.36 -45.65, -39.38 APE12-dist-in 12.643 APE11-dist-in 8.454 APE10-dist-out 12.901 APE9-dist-in 3.434 None None None XRAY 2.17 0.194 0.219 A 300 280 3 0 0 0 [[17, 274]] 1.0 6nfy STE_MAP4K1_HUMAN STE 1.6e-92 315.4 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NFYB Q92918 10 292 833.0 B49:69000 Type1 Inactive DFGin 5.428 14.439 ABAminus -77.59, -12.73 -160.52, 173.22 -94.5, 5.68 304.19, 88.51 70.4, -157.51 out-out out 11.151 Saltbr-out 8.039 HRD-in -66.24, -54.13 78.28, -9.22 out-out-out SNCooo out-out ActLoopNT-out 6.006 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -128.67, 114.08 APE9-dihe-na -99.5, -109.92 APE8-dihe-in -118.15, 107.47 APE8-rot-in 308.81 APE67-dihe-in -64.32, -24.35 -45.36, -36.49 APE12-dist-out 15.067 APE11-dist-in 10.6 APE10-dist-out 15.129 APE9-dist-in 4.289 None None None XRAY 2.17 0.194 0.219 B 300 283 0 0 0 0 [[17, 274]] 1.0 6nfy STE_MAP4K1_HUMAN STE 1.6e-92 315.4 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NFZA Q92918 7 292 833.0 B49:401 Type1 None DFGin 6.284 14.02 BLAminus -132.74, -179.97 58.53, 80.12 -96.32, 31.7 293.92, 71.67 -62.29, -28.15 in-none in 8.634 Saltbr-none 999.0 HRD-in -77.39, -48.16 72.34, -9.45 none-in-in SNCnii in-in ActLoopNT-in 2.838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.28, 161.74 APE9-dihe-na 145.04, -157.57 APE8-dihe-in -127.09, 102.67 APE8-rot-in 298.6 APE67-dihe-in -54.23, -29.76 -34.34, -51.63 APE12-dist-in 8.241 APE11-dist-in 11.626 APE10-dist-in 6.178 APE9-dist-in 3.916 None TPO165,SEP171 TPO165,SEP171 XRAY 2.966 0.209 0.251 A 309 270 16 0 0 0 [[17, 274]] 1.0 6nfz STE_MAP4K1_HUMAN STE 1.7e-92 315.3 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NFZB Q92918 5 292 833.0 B49:9001 Type1 Active DFGin 6.569 14.125 BLAminus -143.42, 177.82 59.84, 65.59 -92.66, 20.58 294.3, 90.38 -59.43, -39.56 in-in in 8.651 Saltbr-in 3.56 HRD-in -78.49, -47.72 65.71, 8.89 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.78, 156.37 APE9-dihe-na 142.37, -174.26 APE8-dihe-in -102.95, 108.5 APE8-rot-in 309.31 APE67-dihe-in -65.17, -28.5 -37.53, -43.95 APE12-dist-in 8.184 APE11-dist-in 11.437 APE10-dist-in 5.975 APE9-dist-in 3.854 None TPO165,SEP171 TPO165,SEP171 XRAY 2.966 0.209 0.251 B 309 277 11 0 0 3 [[17, 274]] 1.0 6nfz STE_MAP4K1_HUMAN STE 1.7e-92 315.3 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NG0A Q92918 6 302 833.0 B49:9000 Type1 Inactive DFGin 5.141 15.065 None -69.74, 172.09 -58.45, 155.47 -142.74, 154.55 54.54, 93.56 67.99, -7.56 out-out out 12.858 Saltbr-out 10.815 HRD-in -63.9, -48.24 77.74, -8.02 out-out-out SNCooo out-out ActLoopNT-out 10.601 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -51.88, -33.41 APE9-dihe-na -72.94, -17.4 APE8-dihe-in -134.99, 76.22 APE8-rot-in 306.88 APE67-dihe-in -54.91, -28.64 -97.55, -2.9 APE12-dist-out 23.075 APE11-dist-out 25.012 APE10-dist-out 24.594 APE9-dist-out 28.735 T165E,S171E None None XRAY 2.05 0.202 0.229 A 309 289 8 0 0 5 [[17, 274]] 1.0 6ng0 STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NG0B Q92918 7 293 833.0 B49:9000 Type1 Inactive DFGout 15.022 9.027 BBAminus -132.93, 173.24 -130.35, 91.11 -75.14, -30.73 272.68, 88.14 -91.62, -130.52 out-out out 11.213 Saltbr-out 7.483 HRD-in -72.09, -46.07 68.34, -7.21 out-out-out SNCooo out-out ActLoopNT-out 6.11 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.37, 118.48 APE9-dihe-na -63.42, 177.66 APE8-dihe-in -42.4, 131.86 APE8-rot-out 56.61 APE67-dihe-in -50.2, -28.57 -93.94, -13.91 APE12-dist-out 19.976 APE11-dist-out 20.334 APE10-dist-out 21.461 APE9-dist-out 26.729 T165E,S171E None None XRAY 2.05 0.202 0.229 B 309 279 8 0 0 0 [[17, 274]] 1.0 6ng0 STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE PAK6 PAK6_HUMAN 4KS8A Q9NQU5 385 671 681.0 B49:701 Type1 Active DFGin 6.345 13.524 BLAminus -140.01, -170.23 63.35, 61.58 -89.05, 6.98 299.26, 108.58 -57.68, -33.0 in-in in 6.958 Saltbr-in 2.913 HRD-in -67.27, -52.49 75.45, -5.04 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.89, 129.35 APE9-dihe-na 153.97, -169.18 APE8-dihe-in -106.27, 121.21 APE8-rot-in 308.12 APE67-dihe-in -63.35, -19.7 -31.2, -62.7 APE12-dist-in 9.871 APE11-dist-in 11.506 APE10-dist-in 5.754 APE9-dist-in 3.36 None SEP560 SEP560 XRAY 1.95 0.22 0.261 A 292 287 0 0 0 0 [[407, 658]] 1.0 4ks8 STE_PAK6_HUMAN STE 2.4e-91 311.6 4 257 254 543 544 545 547 549 436 452 456 523 525 524 526 583 571 566 565 564 563 562 561 560 482 Serine/threonine-protein kinase PAK 6
STE STK24 STK24_HUMAN 4QMZA Q9Y6E0 25 311 443.0 B49:60401 Type1 Active DFGin 6.675 14.657 BLAminus -133.12, 166.14 69.3, 93.82 -111.91, 23.7 289.08, 84.55 -59.76, -25.99 in-in in 8.895 Saltbr-in 2.75 HRD-in -68.41, -48.56 68.12, 3.56 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.76, 163.1 APE9-dihe-na 121.05, -160.77 APE8-dihe-in -122.53, 120.41 APE8-rot-in 306.26 APE67-dihe-in -58.31, -30.91 -44.32, -46.7 APE12-dist-in 8.057 APE11-dist-in 10.804 APE10-dist-in 5.056 APE9-dist-in 3.248 None TPO190 TPO190 XRAY 1.88 0.168 0.224 A 310 287 0 0 0 0 [[36, 286]] 1.0 4qmz STE_STK24_HUMAN STE 3.9e-100 340.4 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TYR ITK ITK_HUMAN 3MIYB Q08881 357 619 620.0 B49:60002 Type1 Inactive DFGin 4.594 14.308 BLAplus -119.14, 168.78 58.23, 44.95 -107.27, 10.53 54.14, 85.29 -87.92, 999.0 in-out in 9.794 Saltbr-out 4.873 HRD-in -72.48, -51.01 80.11, -14.33 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 102.33 APE8-rot-na 353.07 APE67-dihe-in -63.42, -24.1 -64.07, -27.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C477S,E614A,E617A None None XRAY 1.67 0.208 0.234 B 266 238 25 0 0 18 [[363, 614]] 1.0 3miy TYR_ITK_HUMAN TYR 5e-93 317.1 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3MIYA Q08881 357 619 620.0 B49:60001 Type1 Inactive DFGin 4.499 14.327 None -118.72, 169.24 51.5, 47.57 -103.74, 999.0 53.54, 86.2 999.0, 999.0 in-out in 9.828 Saltbr-out 5.045 HRD-in -71.62, -53.3 80.88, -14.93 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.04 APE8-rot-na 334.29 APE67-dihe-in -65.24, -21.92 -59.14, -28.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C477S,E614A,E617A None None XRAY 1.67 0.208 0.234 A 266 237 26 0 0 19 [[363, 614]] 1.0 3miy TYR_ITK_HUMAN TYR 5e-93 317.1 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR KDR VGFR2_HUMAN 4AGDA P35968 802 1169 1356.0 B49:2000 Type1 Inactive DFGout 16.069 10.723 BBAminus -138.96, 169.29 -127.17, 103.68 -55.8, -25.22 266.19, 75.17 52.13, -127.76 in-in in 6.778 Saltbr-in 3.023 HRD-out -100.33, 104.42 -84.72, 20.62 in-out-in SNCioi out-in ActLoopNT-out 15.854 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.84, 115.98 APE9-dihe-in -119.8, 140.98 APE8-dihe-in -66.9, 64.41 APE8-rot-na 27.14 APE67-dihe-in -54.0, -28.9 -62.45, -38.96 APE12-dist-na 16.473 APE11-dist-na 15.651 APE10-dist-na 13.29 APE9-dist-in 7.777 E990V None None XRAY 2.81 0.21 0.307 A 353 304 7 0 0 0 [[834, 1162]] 1.0 4agd TYR_KDR_HUMAN TYR 6e-100 339.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KIT KIT_HUMAN 8S14A P10721 554 931 976.0 B49:61001 Type1 Inactive DFGout 15.67 11.005 BBAminus -130.33, 156.75 -126.16, 102.94 -63.2, -39.5 274.42, 76.71 60.38, -127.64 in-in in 7.027 Saltbr-in 2.555 HRD-in -74.54, -47.39 71.57, -1.96 in-out-in SNCioi out-in ActLoopNT-out 16.165 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.13, 124.86 APE9-dihe-in -134.1, 147.98 APE8-dihe-in -82.5, 68.05 APE8-rot-na 34.36 APE67-dihe-in -70.91, -8.55 -58.2, -39.66 APE12-dist-na 17.889 APE11-dist-na 15.908 APE10-dist-na 13.814 APE9-dist-in 7.606 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.5 0.189 0.214 A 327 292 6 0 0 0 [[589, 926]] 1.0 8s14 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 3G0FA P10721 566 930 976.0 B49:9001 Type1 Inactive DFGout 15.932 11.024 BBAminus -133.24, 143.68 -91.38, 106.1 -85.13, 9.55 260.45, 86.5 -43.92, 131.31 in-in in 7.308 Saltbr-in 2.858 HRD-out -104.98, 124.53 -81.9, 0.65 in-out-in SNCioi out-in ActLoopNT-out 16.723 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.6, 122.46 APE9-dihe-in -125.81, 152.57 APE8-dihe-in -80.31, 82.53 APE8-rot-na 33.57 APE67-dihe-in -64.38, -18.09 -77.28, -33.89 APE12-dist-na 17.512 APE11-dist-na 13.756 APE10-dist-na 12.661 APE9-dist-in 7.497 D816H None None XRAY 2.6 0.212 0.255 A 336 291 16 0 0 0 [[589, 926]] 1.0 3g0f TYR_KIT_HUMAN TYR 9.5e-102 346.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 3G0FB P10721 564 930 976.0 B49:9001 Type1 Inactive DFGout 16.025 10.608 BBAminus -141.97, 146.96 -100.97, 117.58 -98.35, 1.5 249.66, 85.76 -37.59, 131.92 in-in in 7.372 Saltbr-in 2.84 HRD-out -103.28, 116.42 -91.73, 18.13 in-out-in SNCioi out-in ActLoopNT-out 16.63 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.56, 113.86 APE9-dihe-in -119.17, 158.81 APE8-dihe-in -86.16, 69.24 APE8-rot-na 31.3 APE67-dihe-in -71.68, -15.15 -66.98, -25.93 APE12-dist-na 16.574 APE11-dist-na 13.473 APE10-dist-na 12.13 APE9-dist-in 7.192 D816H None None XRAY 2.6 0.212 0.255 B 336 293 16 0 0 0 [[589, 926]] 1.0 3g0f TYR_KIT_HUMAN TYR 9.5e-102 346.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 3G0EA P10721 544 931 976.0 B49:69000 Type1 Inactive DFGout 17.746 11.185 None -121.33, 151.46 -96.26, 99.11 -97.45, -2.26 201.86, 86.92 -50.22, -44.62 in-in in 7.975 Saltbr-in 2.741 HRD-in -84.75, -49.91 86.53, -14.09 in-out-in SNCioi out-in ActLoopNT-out 17.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.72, 116.38 APE9-dihe-in -130.06, 149.91 APE8-dihe-in -78.23, 61.24 APE8-rot-na 30.2 APE67-dihe-in -67.26, -15.34 -60.23, -32.65 APE12-dist-na 20.171 APE11-dist-na 16.418 APE10-dist-na 14.346 APE9-dist-in 7.896 None None None XRAY 1.6 0.201 0.212 A 336 330 0 0 0 0 [[589, 926]] 1.0 3g0e TYR_KIT_HUMAN TYR 4.8e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR PDGFRA PGFRA_HUMAN 6JOKA P16234 556 973 1089.0 B49:1001 Type1 Inactive DFGout 17.33 10.152 None -157.96, 162.23 -90.74, 118.75 -83.04, 4.75 220.32, 127.42 -60.76, -49.9 in-out in 7.806 Saltbr-out 4.609 HRD-in -71.4, -52.83 71.29, -1.66 out-out-in SNCooi out-in ActLoopNT-out 16.719 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.37, 126.64 APE9-dihe-in -119.51, 140.56 APE8-dihe-in -75.53, 69.74 APE8-rot-na 31.06 APE67-dihe-in -63.68, -19.63 -58.21, -43.02 APE12-dist-na 17.503 APE11-dist-na 14.289 APE10-dist-na 13.198 APE9-dist-in 7.286 None None None XRAY 3.8 0.259 0.282 A 356 338 8 0 0 0 [[593, 952]] 1.0 6jok TYR_PDGFRA_HUMAN TYR 9.2e-107 362.5 1 260 260 835 836 837 839 841 627 644 648 815 817 816 818 877 865 860 859 858 857 856 855 854 675 Platelet-derived growth factor receptor alpha

Ligand: B49 (Sunitinib, Sutent)

Total number of chains: 23
Active chains: 5
Total number of genes: 10
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 43.5% 4QMZA
DFGout BBAminus 5 21.7% 8S14A
DFGin ABAminus 2 8.7% 6NFYB
DFGin None 2 8.7% 6NG0A
DFGout None 2 8.7% 3G0EA
DFGin BLAplus 1 4.3% 3MIYB
DFGin BLBminus 1 4.3% 3TI1A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK PHKG2 PHKG2_HUMAN 2Y7JA P15735 10 293 406.0 B49:1294 Type1 Inactive DFGin 6.665 14.816 BLAminus -136.35, -170.16 54.75, 70.88 -92.39, 20.81 284.08, 76.85 -61.83, -24.19 out-out out 10.25 Saltbr-out 4.465 HRD-in -62.79, -53.07 70.61, 18.6 out-in-in SNCoii in-in ActLoopNT-in 3.006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.94, 142.23 APE9-dihe-na 122.3, 163.86 APE8-dihe-in -75.83, 126.85 APE8-rot-in 314.78 APE67-dihe-in -61.19, -25.01 -48.83, -43.94 APE12-dist-in 8.699 APE11-dist-in 11.31 APE10-dist-in 5.755 APE9-dist-in 3.515 None None None XRAY 2.5 0.184 0.216 A 365 284 0 0 0 0 [[24, 291]] 1.0 2y7j Homo sapiens CAMK_PHKG2_HUMAN CAMK 3.8e-87 298.0 1 256 256 170 171 172 174 176 53 77 81 150 152 151 153 215 197 192 191 190 189 188 187 186 108 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
CAMK PHKG2 PHKG2_HUMAN 2Y7JB P15735 10 293 406.0 B49:1294 Type1 Inactive DFGin 6.564 15.201 BLAminus -134.53, -168.98 53.87, 69.09 -88.65, 24.72 282.53, 76.39 -61.6, -27.15 out-out out 10.429 Saltbr-out 4.803 HRD-in -65.97, -49.45 65.68, 10.08 out-in-in SNCoii in-in ActLoopNT-in 3.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.71, 165.45 APE9-dihe-na 107.35, 176.19 APE8-dihe-in -84.88, 130.97 APE8-rot-in 310.21 APE67-dihe-in -62.86, -22.06 -48.14, -44.88 APE12-dist-in 8.415 APE11-dist-in 11.113 APE10-dist-in 5.483 APE9-dist-in 3.354 None None None XRAY 2.5 0.184 0.216 B 365 281 3 0 0 0 [[24, 291]] 1.0 2y7j Homo sapiens CAMK_PHKG2_HUMAN CAMK 3.8e-87 298.0 1 256 256 170 171 172 174 176 53 77 81 150 152 151 153 215 197 192 191 190 189 188 187 186 108 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
CAMK PHKG2 PHKG2_HUMAN 2Y7JC P15735 10 293 406.0 B49:1294 Type1 Inactive DFGin 6.771 14.996 BLAminus -128.01, -166.61 49.58, 75.18 -93.06, 22.57 284.6, 75.8 -62.72, -24.5 out-out out 10.554 Saltbr-out 4.793 HRD-in -67.86, -49.01 71.89, 11.92 out-in-in SNCoii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.59, 158.94 APE9-dihe-na 110.48, 179.0 APE8-dihe-in -88.44, 129.7 APE8-rot-in 310.49 APE67-dihe-in -63.94, -22.15 -49.61, -43.54 APE12-dist-in 8.456 APE11-dist-in 11.047 APE10-dist-in 5.43 APE9-dist-in 3.556 None None None XRAY 2.5 0.184 0.216 C 365 284 0 0 0 0 [[24, 291]] 1.0 2y7j Homo sapiens CAMK_PHKG2_HUMAN CAMK 3.8e-87 298.0 1 256 256 170 171 172 174 176 53 77 81 150 152 151 153 215 197 192 191 190 189 188 187 186 108 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
CAMK PHKG2 PHKG2_HUMAN 2Y7JD P15735 10 293 406.0 B49:1294 Type1 Inactive DFGin 6.641 15.224 BLAminus -131.7, -173.29 54.45, 74.24 -92.53, 24.77 283.53, 75.93 -62.64, -24.73 out-out out 10.594 Saltbr-out 4.893 HRD-in -65.75, -51.36 68.23, 9.72 out-in-in SNCoii in-in ActLoopNT-in 2.994 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.1, 164.39 APE9-dihe-na 106.84, 174.06 APE8-dihe-in -83.97, 130.15 APE8-rot-in 310.84 APE67-dihe-in -63.49, -21.75 -48.4, -43.95 APE12-dist-in 8.517 APE11-dist-in 11.197 APE10-dist-in 5.527 APE9-dist-in 3.329 None None None XRAY 2.5 0.184 0.216 D 365 281 3 0 0 0 [[24, 291]] 1.0 2y7j Homo sapiens CAMK_PHKG2_HUMAN CAMK 3.8e-87 298.0 1 256 256 170 171 172 174 176 53 77 81 150 152 151 153 215 197 192 191 190 189 188 187 186 108 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
CMGC CDK2 CDK2_HUMAN 3TI1A P24941 1 298 298.0 B49:299 Type1 Inactive DFGin 7.489 14.948 BLBminus -138.54, 165.85 55.25, 50.84 -54.7, 138.08 282.79, 63.1 -95.42, 15.79 out-out out 16.039 Saltbr-out 14.61 HRD-in -73.91, -54.49 74.09, -22.19 out-out-out SNCooo out-out ActLoopNT-out 7.753 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -103.63, 110.78 APE9-dihe-na -67.36, 128.32 APE8-dihe-in -75.16, 126.28 APE8-rot-in 271.07 APE67-dihe-in -58.11, -32.93 -95.87, -2.85 APE12-dist-out 22.302 APE11-dist-out 17.662 APE10-dist-out 19.612 APE9-dist-out 10.928 None None None XRAY 1.99 0.205 0.262 A 298 294 4 0 0 0 [[4, 286]] 1.0 3ti1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
STE MAP4K1 M4K1_HUMAN 6NFYA Q92918 10 292 833.0 B49:69000 Type1 Inactive DFGin 5.593 14.914 ABAminus -77.99, -10.08 -165.37, 178.6 -100.73, 5.46 299.9, 89.52 78.01, -158.47 out-out out 11.415 Saltbr-out 8.806 HRD-in -67.76, -54.16 80.53, -5.66 out-out-out SNCooo out-out ActLoopNT-out 5.972 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -122.43, 132.12 APE9-dihe-na -84.67, -151.78 APE8-dihe-in -82.18, 120.44 APE8-rot-in 317.02 APE67-dihe-in -65.57, -25.36 -45.65, -39.38 APE12-dist-in 12.643 APE11-dist-in 8.454 APE10-dist-out 12.901 APE9-dist-in 3.434 None None None XRAY 2.17 0.194 0.219 A 300 280 3 0 0 0 [[17, 274]] 1.0 6nfy Homo sapiens STE_MAP4K1_HUMAN STE 1.6e-92 315.4 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NFYB Q92918 10 292 833.0 B49:69000 Type1 Inactive DFGin 5.428 14.439 ABAminus -77.59, -12.73 -160.52, 173.22 -94.5, 5.68 304.19, 88.51 70.4, -157.51 out-out out 11.151 Saltbr-out 8.039 HRD-in -66.24, -54.13 78.28, -9.22 out-out-out SNCooo out-out ActLoopNT-out 6.006 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -128.67, 114.08 APE9-dihe-na -99.5, -109.92 APE8-dihe-in -118.15, 107.47 APE8-rot-in 308.81 APE67-dihe-in -64.32, -24.35 -45.36, -36.49 APE12-dist-out 15.067 APE11-dist-in 10.6 APE10-dist-out 15.129 APE9-dist-in 4.289 None None None XRAY 2.17 0.194 0.219 B 300 283 0 0 0 0 [[17, 274]] 1.0 6nfy Homo sapiens STE_MAP4K1_HUMAN STE 1.6e-92 315.4 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NFZA Q92918 7 292 833.0 B49:401 Type1 None DFGin 6.284 14.02 BLAminus -132.74, -179.97 58.53, 80.12 -96.32, 31.7 293.92, 71.67 -62.29, -28.15 in-none in 8.634 Saltbr-none 999.0 HRD-in -77.39, -48.16 72.34, -9.45 none-in-in SNCnii in-in ActLoopNT-in 2.838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.28, 161.74 APE9-dihe-na 145.04, -157.57 APE8-dihe-in -127.09, 102.67 APE8-rot-in 298.6 APE67-dihe-in -54.23, -29.76 -34.34, -51.63 APE12-dist-in 8.241 APE11-dist-in 11.626 APE10-dist-in 6.178 APE9-dist-in 3.916 None TPO165,SEP171 TPO165,SEP171 XRAY 2.966 0.209 0.251 A 309 270 16 0 0 0 [[17, 274]] 1.0 6nfz Homo sapiens STE_MAP4K1_HUMAN STE 1.7e-92 315.3 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NFZB Q92918 5 292 833.0 B49:9001 Type1 Active DFGin 6.569 14.125 BLAminus -143.42, 177.82 59.84, 65.59 -92.66, 20.58 294.3, 90.38 -59.43, -39.56 in-in in 8.651 Saltbr-in 3.56 HRD-in -78.49, -47.72 65.71, 8.89 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.78, 156.37 APE9-dihe-na 142.37, -174.26 APE8-dihe-in -102.95, 108.5 APE8-rot-in 309.31 APE67-dihe-in -65.17, -28.5 -37.53, -43.95 APE12-dist-in 8.184 APE11-dist-in 11.437 APE10-dist-in 5.975 APE9-dist-in 3.854 None TPO165,SEP171 TPO165,SEP171 XRAY 2.966 0.209 0.251 B 309 277 11 0 0 3 [[17, 274]] 1.0 6nfz Homo sapiens STE_MAP4K1_HUMAN STE 1.7e-92 315.3 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NG0A Q92918 6 302 833.0 B49:9000 Type1 Inactive DFGin 5.141 15.065 None -69.74, 172.09 -58.45, 155.47 -142.74, 154.55 54.54, 93.56 67.99, -7.56 out-out out 12.858 Saltbr-out 10.815 HRD-in -63.9, -48.24 77.74, -8.02 out-out-out SNCooo out-out ActLoopNT-out 10.601 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -51.88, -33.41 APE9-dihe-na -72.94, -17.4 APE8-dihe-in -134.99, 76.22 APE8-rot-in 306.88 APE67-dihe-in -54.91, -28.64 -97.55, -2.9 APE12-dist-out 23.075 APE11-dist-out 25.012 APE10-dist-out 24.594 APE9-dist-out 28.735 T165E,S171E None None XRAY 2.05 0.202 0.229 A 309 289 8 0 0 5 [[17, 274]] 1.0 6ng0 Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6NG0B Q92918 7 293 833.0 B49:9000 Type1 Inactive DFGout 15.022 9.027 BBAminus -132.93, 173.24 -130.35, 91.11 -75.14, -30.73 272.68, 88.14 -91.62, -130.52 out-out out 11.213 Saltbr-out 7.483 HRD-in -72.09, -46.07 68.34, -7.21 out-out-out SNCooo out-out ActLoopNT-out 6.11 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.37, 118.48 APE9-dihe-na -63.42, 177.66 APE8-dihe-in -42.4, 131.86 APE8-rot-out 56.61 APE67-dihe-in -50.2, -28.57 -93.94, -13.91 APE12-dist-out 19.976 APE11-dist-out 20.334 APE10-dist-out 21.461 APE9-dist-out 26.729 T165E,S171E None None XRAY 2.05 0.202 0.229 B 309 279 8 0 0 0 [[17, 274]] 1.0 6ng0 Homo sapiens STE_MAP4K1_HUMAN STE 4.9e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE PAK6 PAK6_HUMAN 4KS8A Q9NQU5 385 671 681.0 B49:701 Type1 Active DFGin 6.345 13.524 BLAminus -140.01, -170.23 63.35, 61.58 -89.05, 6.98 299.26, 108.58 -57.68, -33.0 in-in in 6.958 Saltbr-in 2.913 HRD-in -67.27, -52.49 75.45, -5.04 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.89, 129.35 APE9-dihe-na 153.97, -169.18 APE8-dihe-in -106.27, 121.21 APE8-rot-in 308.12 APE67-dihe-in -63.35, -19.7 -31.2, -62.7 APE12-dist-in 9.871 APE11-dist-in 11.506 APE10-dist-in 5.754 APE9-dist-in 3.36 None SEP560 SEP560 XRAY 1.95 0.22 0.261 A 292 287 0 0 0 0 [[407, 658]] 1.0 4ks8 Homo sapiens STE_PAK6_HUMAN STE 2.4e-91 311.6 4 257 254 543 544 545 547 549 436 452 456 523 525 524 526 583 571 566 565 564 563 562 561 560 482 Serine/threonine-protein kinase PAK 6
STE STK24 STK24_HUMAN 4QMZA Q9Y6E0 25 311 443.0 B49:60401 Type1 Active DFGin 6.675 14.657 BLAminus -133.12, 166.14 69.3, 93.82 -111.91, 23.7 289.08, 84.55 -59.76, -25.99 in-in in 8.895 Saltbr-in 2.75 HRD-in -68.41, -48.56 68.12, 3.56 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.76, 163.1 APE9-dihe-na 121.05, -160.77 APE8-dihe-in -122.53, 120.41 APE8-rot-in 306.26 APE67-dihe-in -58.31, -30.91 -44.32, -46.7 APE12-dist-in 8.057 APE11-dist-in 10.804 APE10-dist-in 5.056 APE9-dist-in 3.248 None TPO190 TPO190 XRAY 1.88 0.168 0.224 A 310 287 0 0 0 0 [[36, 286]] 1.0 4qmz Homo sapiens STE_STK24_HUMAN STE 3.9e-100 340.4 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TYR ITK ITK_HUMAN 3MIYB Q08881 357 619 620.0 B49:60002 Type1 Inactive DFGin 4.594 14.308 BLAplus -119.14, 168.78 58.23, 44.95 -107.27, 10.53 54.14, 85.29 -87.92, 999.0 in-out in 9.794 Saltbr-out 4.873 HRD-in -72.48, -51.01 80.11, -14.33 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 102.33 APE8-rot-na 353.07 APE67-dihe-in -63.42, -24.1 -64.07, -27.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C477S,E614A,E617A None None XRAY 1.67 0.208 0.234 B 266 238 25 0 0 18 [[363, 614]] 1.0 3miy Homo sapiens TYR_ITK_HUMAN TYR 5e-93 317.1 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 3MIYA Q08881 357 619 620.0 B49:60001 Type1 Inactive DFGin 4.499 14.327 None -118.72, 169.24 51.5, 47.57 -103.74, 999.0 53.54, 86.2 999.0, 999.0 in-out in 9.828 Saltbr-out 5.045 HRD-in -71.62, -53.3 80.88, -14.93 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 84.04 APE8-rot-na 334.29 APE67-dihe-in -65.24, -21.92 -59.14, -28.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C477S,E614A,E617A None None XRAY 1.67 0.208 0.234 A 266 237 26 0 0 19 [[363, 614]] 1.0 3miy Homo sapiens TYR_ITK_HUMAN TYR 5e-93 317.1 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR KDR VGFR2_HUMAN 4AGDA P35968 802 1169 1356.0 B49:2000 Type1 Inactive DFGout 16.069 10.723 BBAminus -138.96, 169.29 -127.17, 103.68 -55.8, -25.22 266.19, 75.17 52.13, -127.76 in-in in 6.778 Saltbr-in 3.023 HRD-out -100.33, 104.42 -84.72, 20.62 in-out-in SNCioi out-in ActLoopNT-out 15.854 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.84, 115.98 APE9-dihe-in -119.8, 140.98 APE8-dihe-in -66.9, 64.41 APE8-rot-na 27.14 APE67-dihe-in -54.0, -28.9 -62.45, -38.96 APE12-dist-na 16.473 APE11-dist-na 15.651 APE10-dist-na 13.29 APE9-dist-in 7.777 E990V None None XRAY 2.81 0.21 0.307 A 353 304 7 0 0 0 [[834, 1162]] 1.0 4agd Homo sapiens TYR_KDR_HUMAN TYR 6e-100 339.8 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KIT KIT_HUMAN 8S14A P10721 554 931 976.0 B49:61001 Type1 Inactive DFGout 15.67 11.005 BBAminus -130.33, 156.75 -126.16, 102.94 -63.2, -39.5 274.42, 76.71 60.38, -127.64 in-in in 7.027 Saltbr-in 2.555 HRD-in -74.54, -47.39 71.57, -1.96 in-out-in SNCioi out-in ActLoopNT-out 16.165 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.13, 124.86 APE9-dihe-in -134.1, 147.98 APE8-dihe-in -82.5, 68.05 APE8-rot-na 34.36 APE67-dihe-in -70.91, -8.55 -58.2, -39.66 APE12-dist-na 17.889 APE11-dist-na 15.908 APE10-dist-na 13.814 APE9-dist-in 7.606 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.5 0.189 0.214 A 327 292 6 0 0 0 [[589, 926]] 1.0 8s14 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 3G0FA P10721 566 930 976.0 B49:9001 Type1 Inactive DFGout 15.932 11.024 BBAminus -133.24, 143.68 -91.38, 106.1 -85.13, 9.55 260.45, 86.5 -43.92, 131.31 in-in in 7.308 Saltbr-in 2.858 HRD-out -104.98, 124.53 -81.9, 0.65 in-out-in SNCioi out-in ActLoopNT-out 16.723 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.6, 122.46 APE9-dihe-in -125.81, 152.57 APE8-dihe-in -80.31, 82.53 APE8-rot-na 33.57 APE67-dihe-in -64.38, -18.09 -77.28, -33.89 APE12-dist-na 17.512 APE11-dist-na 13.756 APE10-dist-na 12.661 APE9-dist-in 7.497 D816H None None XRAY 2.6 0.212 0.255 A 336 291 16 0 0 0 [[589, 926]] 1.0 3g0f Homo sapiens TYR_KIT_HUMAN TYR 9.5e-102 346.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 3G0FB P10721 564 930 976.0 B49:9001 Type1 Inactive DFGout 16.025 10.608 BBAminus -141.97, 146.96 -100.97, 117.58 -98.35, 1.5 249.66, 85.76 -37.59, 131.92 in-in in 7.372 Saltbr-in 2.84 HRD-out -103.28, 116.42 -91.73, 18.13 in-out-in SNCioi out-in ActLoopNT-out 16.63 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.56, 113.86 APE9-dihe-in -119.17, 158.81 APE8-dihe-in -86.16, 69.24 APE8-rot-na 31.3 APE67-dihe-in -71.68, -15.15 -66.98, -25.93 APE12-dist-na 16.574 APE11-dist-na 13.473 APE10-dist-na 12.13 APE9-dist-in 7.192 D816H None None XRAY 2.6 0.212 0.255 B 336 293 16 0 0 0 [[589, 926]] 1.0 3g0f Homo sapiens TYR_KIT_HUMAN TYR 9.5e-102 346.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 3G0EA P10721 544 931 976.0 B49:69000 Type1 Inactive DFGout 17.746 11.185 None -121.33, 151.46 -96.26, 99.11 -97.45, -2.26 201.86, 86.92 -50.22, -44.62 in-in in 7.975 Saltbr-in 2.741 HRD-in -84.75, -49.91 86.53, -14.09 in-out-in SNCioi out-in ActLoopNT-out 17.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.72, 116.38 APE9-dihe-in -130.06, 149.91 APE8-dihe-in -78.23, 61.24 APE8-rot-na 30.2 APE67-dihe-in -67.26, -15.34 -60.23, -32.65 APE12-dist-na 20.171 APE11-dist-na 16.418 APE10-dist-na 14.346 APE9-dist-in 7.896 None None None XRAY 1.6 0.201 0.212 A 336 330 0 0 0 0 [[589, 926]] 1.0 3g0e Homo sapiens TYR_KIT_HUMAN TYR 4.8e-102 347.0 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR PDGFRA PGFRA_HUMAN 6JOKA P16234 556 973 1089.0 B49:1001 Type1 Inactive DFGout 17.33 10.152 None -157.96, 162.23 -90.74, 118.75 -83.04, 4.75 220.32, 127.42 -60.76, -49.9 in-out in 7.806 Saltbr-out 4.609 HRD-in -71.4, -52.83 71.29, -1.66 out-out-in SNCooi out-in ActLoopNT-out 16.719 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.37, 126.64 APE9-dihe-in -119.51, 140.56 APE8-dihe-in -75.53, 69.74 APE8-rot-na 31.06 APE67-dihe-in -63.68, -19.63 -58.21, -43.02 APE12-dist-na 17.503 APE11-dist-na 14.289 APE10-dist-na 13.198 APE9-dist-in 7.286 None None None XRAY 3.8 0.259 0.282 A 356 338 8 0 0 0 [[593, 952]] 1.0 6jok Homo sapiens TYR_PDGFRA_HUMAN TYR 9.2e-107 362.5 1 260 260 835 836 837 839 841 627 644 648 815 817 816 818 877 865 860 859 858 857 856 855 854 675 Platelet-derived growth factor receptor alpha
OTHER RNASEL A5H025_PIG 6M11A A5H025 22 727 743.0 25A:1000,B49:1001 Allosteric,Type1 Active DFGin 6.478 12.988 BLAminus -155.56, -175.42 53.36, 69.23 -78.35, 0.82 299.16, 87.45 -44.61, -27.7 in-in in 6.997 Saltbr-in 2.76 HRD-in -77.65, -46.61 73.81, -8.63 in-in-na SNCiia in-na ActLoopNT-in 2.919 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -150.91, 91.82 APE9-dihe-na -58.05, -29.31 APE8-dihe-na -85.86, 5.21 APE8-rot-na 81.56 APE67-dihe-na -49.78, -40.92 -78.75, -14.68 APE12-dist-na 15.801 APE11-dist-na 12.511 APE10-dist-na 13.197 APE9-dist-na 13.898 None None None XRAY 2.46 0.223 0.285 a 717 681 3 0 0 0 [[351, 591]] 1.0 6m11 Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 6M11B A5H025 23 727 743.0 25A:801,B49:802 Allosteric,Type1 Active DFGin 6.431 12.916 BLAminus -135.39, -175.08 63.06, 58.49 -90.2, 44.42 312.3, 86.88 -87.38, -12.11 in-in in 7.066 Saltbr-in 2.75 HRD-in -74.93, -49.19 77.69, -5.89 in-in-na SNCiia in-na ActLoopNT-in 2.89 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -145.22, 69.59 APE9-dihe-na -60.88, -23.05 APE8-dihe-na -93.06, -0.03 APE8-rot-na 81.83 APE67-dihe-na -42.69, -43.6 -77.55, -16.15 APE12-dist-na 15.985 APE11-dist-na 13.983 APE10-dist-na 12.943 APE9-dist-na 14.252 None None None XRAY 2.46 0.223 0.285 b 717 684 0 0 0 0 [[351, 591]] 1.0 6m11 Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L

Ligand: B49 (Sunitinib, Sutent)

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 6M11b
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER RNASEL A5H025_PIG 6M11A A5H025 22 727 743.0 25A:1000,B49:1001 Allosteric,Type1 Active DFGin 6.478 12.988 BLAminus -155.56, -175.42 53.36, 69.23 -78.35, 0.82 299.16, 87.45 -44.61, -27.7 in-in in 6.997 Saltbr-in 2.76 HRD-in -77.65, -46.61 73.81, -8.63 in-in-na SNCiia in-na ActLoopNT-in 2.919 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -150.91, 91.82 APE9-dihe-na -58.05, -29.31 APE8-dihe-na -85.86, 5.21 APE8-rot-na 81.56 APE67-dihe-na -49.78, -40.92 -78.75, -14.68 APE12-dist-na 15.801 APE11-dist-na 12.511 APE10-dist-na 13.197 APE9-dist-na 13.898 None None None XRAY 2.46 0.223 0.285 a 717 681 3 0 0 0 [[351, 591]] 1.0 6m11 Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 6M11B A5H025 23 727 743.0 25A:801,B49:802 Allosteric,Type1 Active DFGin 6.431 12.916 BLAminus -135.39, -175.08 63.06, 58.49 -90.2, 44.42 312.3, 86.88 -87.38, -12.11 in-in in 7.066 Saltbr-in 2.75 HRD-in -74.93, -49.19 77.69, -5.89 in-in-na SNCiia in-na ActLoopNT-in 2.89 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -145.22, 69.59 APE9-dihe-na -60.88, -23.05 APE8-dihe-na -93.06, -0.03 APE8-rot-na 81.83 APE67-dihe-na -42.69, -43.6 -77.55, -16.15 APE12-dist-na 15.985 APE11-dist-na 13.983 APE10-dist-na 12.943 APE9-dist-na 14.252 None None None XRAY 2.46 0.223 0.285 b 717 684 0 0 0 0 [[351, 591]] 1.0 6m11 Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L