Ligand

Protein kinases in complex with Q4J (Pralsetinib)

Total number of genes: 1

Total number of chains: 4

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	4	7JU5B

Database table as tsv

Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type
TYR	RET	RET_HUMAN	Proto-oncogene tyrosine-protein kinase receptor Ret	7DU9A	2.31	Active	DFGin	BLAminus	in-in	in-in	Q4J	Type1
TYR	RET	RET_HUMAN	Proto-oncogene tyrosine-protein kinase receptor Ret	7DU9B	2.31	Active	DFGin	BLAminus	in-in	in-in	Q4J	Type1
TYR	RET	RET_HUMAN	Proto-oncogene tyrosine-protein kinase receptor Ret	7JU5A	1.9	Active	DFGin	BLAminus	in-in	in-in	Q4J	Type1
TYR	RET	RET_HUMAN	Proto-oncogene tyrosine-protein kinase receptor Ret	7JU5B	1.9	Active	DFGin	BLAminus	in-in	in-in	Q4J	Type1

Protein kinases in complex with Q4J

Total number of genes: 1

Total number of chains: 4

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	4	7JU5B

Database table as tsv

Organism	Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type
Homo sapiens	TYR	RET	RET_HUMAN	Proto-oncogene tyrosine-protein kinase receptor Ret	7DU9A	2.31	Active	DFGin	BLAminus	in-in	in-in	Q4J	Type1
Homo sapiens	TYR	RET	RET_HUMAN	Proto-oncogene tyrosine-protein kinase receptor Ret	7DU9B	2.31	Active	DFGin	BLAminus	in-in	in-in	Q4J	Type1
Homo sapiens	TYR	RET	RET_HUMAN	Proto-oncogene tyrosine-protein kinase receptor Ret	7JU5A	1.9	Active	DFGin	BLAminus	in-in	in-in	Q4J	Type1
Homo sapiens	TYR	RET	RET_HUMAN	Proto-oncogene tyrosine-protein kinase receptor Ret	7JU5B	1.9	Active	DFGin	BLAminus	in-in	in-in	Q4J	Type1

Protein kinases in complex with Q4J

Total number of genes: 0

Total number of chains: 0

Spatial	Dihedral	Chains	Representative

Database table as tsv

Organism	Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type