Ligand: Q4J (Pralsetinib)

Total number of chains: 4
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 4 7JU5B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR RET RET_HUMAN 7DU9A 2.31 Inactive DFGin‑BLAminus in-in in-out Q4J Type1 714 - 1011 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 7DU9B 2.31 Inactive DFGin‑BLAminus in-in in-out Q4J Type1 705 - 1012 10 None None Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 7JU5A 1.9 Inactive DFGin‑BLAminus in-in in-out Q4J Type1 705 - 1013 8 None None Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 7JU5B 1.9 Inactive DFGin‑BLAminus in-in in-out Q4J Type1 710 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret

Ligand: Q4J (Pralsetinib)

Total number of chains: 4
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 4 7JU5B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR RET RET_HUMAN 7DU9A 2.31 Inactive DFGin‑BLAminus in-in in-out Q4J Type1 714 - 1011 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
TYR RET RET_HUMAN 7DU9B 2.31 Inactive DFGin‑BLAminus in-in in-out Q4J Type1 705 - 1012 10 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
TYR RET RET_HUMAN 7JU5A 1.9 Inactive DFGin‑BLAminus in-in in-out Q4J Type1 705 - 1013 8 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
TYR RET RET_HUMAN 7JU5B 1.9 Inactive DFGin‑BLAminus in-in in-out Q4J Type1 710 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens

Ligand: Q4J (Pralsetinib)

Total number of chains: 0
Spatial label Dihedral label Number of Chains Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism