TYR_RET (Proto-oncogene tyrosine-protein kinase receptor Ret)

Total number of chains: 38
Active chains: 2
Family: TYR
Uniprot: RET_HUMAN
Kinase Domain Residues: 724 - 1007
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 38 100.0% AF-P07949-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P07949-K1A 716 1015 1114.0 No_ligand No_ligand Active DFGin 6.828 14.036 BLAminus -143.32, 176.07 65.43, 64.62 -86.23, 13.69 292.95, 85.62 -60.38, -34.34 in-in in 7.648 Saltbr-in 2.599 HRD-in -70.64, -41.86 68.21, -20.18 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.53, 146.83 APE9-dihe-in -136.18, 140.71 APE8-dihe-in -80.57, 71.62 APE8-rot-na 35.04 APE67-dihe-in -72.87, -15.17 -45.11, -40.91 APE12-dist-na 14.531 APE11-dist-na 10.052 APE10-dist-na 10.409 APE9-dist-in 7.076 None None None AF2 -1.0 1.0 1.0 A 300 300 0 0 0 0 [[724, 1007]] 1.0 AF-P07949-K1 TYR_RET_HUMAN TYR 3.4e-101 343.8 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
AF-P07949-K3A 716 1015 1114.0 No_ligand No_ligand Active DFGin 6.685 13.739 BLAminus -145.92, 179.52 65.99, 59.7 -79.85, 12.57 294.52, 86.95 -60.42, -32.03 in-in in 7.693 Saltbr-in 2.616 HRD-in -73.1, -42.04 65.97, -12.14 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.53, 134.45 APE9-dihe-in -131.95, 144.91 APE8-dihe-in -82.65, 62.78 APE8-rot-na 36.76 APE67-dihe-in -71.83, -7.8 -41.21, -43.71 APE12-dist-na 14.348 APE11-dist-na 10.528 APE10-dist-na 10.185 APE9-dist-in 6.907 None None None AF2 -1.0 1.0 1.0 A 300 300 0 0 0 0 [[724, 1007]] 1.0 AF-P07949-K3 TYR_RET_HUMAN TYR 3.4e-101 343.8 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
2IVTA 703 1012 1114.0 AMP:63015 ATPlike Inactive DFGin 6.582 14.046 BLAminus -135.2, 176.38 61.74, 80.34 -103.81, 14.47 281.76, 90.09 -59.35, -34.21 in-in in 7.234 Saltbr-in 2.737 HRD-in -77.56, -43.39 78.85, -29.33 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.53, 33.76 APE9-dihe-in -110.13, 138.63 APE8-dihe-in -57.62, 135.06 APE8-rot-na 332.88 APE67-dihe-in -80.74, -4.59 -59.92, -27.73 APE12-dist-na 13.764 APE11-dist-na 9.424 APE10-dist-na 8.046 APE9-dist-in 5.596 None PTR905 PTR905 XRAY 2.6 0.187 0.249 A 314 286 21 0 0 0 [[724, 1007]] 1.0 2ivt TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
6NE7A 705 1013 1114.0 AMP:61103 ATPlike Inactive DFGin 6.727 14.262 BLAminus -136.24, -174.2 57.88, 74.27 -97.52, 17.22 284.41, 79.78 -59.81, -27.59 in-in in 7.093 Saltbr-in 2.608 HRD-in -73.16, -50.61 79.87, -20.93 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.57, 19.09 APE9-dihe-in -87.06, 133.71 APE8-dihe-in -50.0, 126.08 APE8-rot-na 331.41 APE67-dihe-in -72.8, -6.12 -42.6, -44.71 APE12-dist-na 13.52 APE11-dist-na 9.107 APE10-dist-na 7.618 APE9-dist-in 5.218 G810A PTR900,PTR905 PTR900,PTR905 XRAY 1.99 0.206 0.249 A 314 290 19 0 0 0 [[724, 1007]] 1.0 6ne7 TYR_RET_HUMAN TYR 7.8e-100 339.4 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
5AMNA 705 1010 1114.0 DTQ:62018 Type1 Inactive DFGin 6.924 14.481 BLAminus -129.35, -171.61 56.5, 78.55 -104.27, 12.34 284.28, 84.08 -59.73, -21.54 in-in in 7.48 Saltbr-in 2.779 HRD-in -71.89, -48.34 77.05, -6.64 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.95, 28.12 APE9-dihe-in -97.69, 135.77 APE8-dihe-in -52.26, 130.31 APE8-rot-na 328.98 APE67-dihe-in -75.47, -2.3 -49.07, -44.55 APE12-dist-na 13.744 APE11-dist-na 9.273 APE10-dist-na 8.313 APE9-dist-in 5.528 None PTR900,PTR905 PTR900,PTR905 XRAY 2.57 0.186 0.237 A 299 284 6 0 0 0 [[724, 1007]] 1.0 5amn TYR_RET_HUMAN TYR 2.4e-101 344.3 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
6FEKA 705 1010 1114.0 ADN:61104 Type1 Inactive DFGin 6.767 13.821 BLAminus -141.99, -171.41 59.54, 71.43 -98.37, 12.19 284.75, 93.0 -64.4, -26.64 in-none in 7.246 Saltbr-none 999.0 HRD-in -77.44, -40.12 73.87, -24.59 none-in-out SNCnio in-out ActLoopNT-in 2.971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.75, 17.41 APE9-dihe-in -84.07, 140.52 APE8-dihe-in -58.1, 137.81 APE8-rot-na 331.87 APE67-dihe-in -76.24, -0.91 -55.46, -40.98 APE12-dist-na 13.861 APE11-dist-na 9.442 APE10-dist-na 7.876 APE9-dist-in 5.294 S904F PTR900,PTR905 PTR900,PTR905 XRAY 2.3 0.203 0.244 A 299 291 0 0 0 0 [[724, 1007]] 1.0 6fek TYR_RET_HUMAN TYR 8.2e-101 342.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
6I82A 705 1012 1114.0 H6W:61101 Type1 Inactive DFGin 6.849 14.471 BLAminus -128.14, -174.21 67.72, 61.92 -90.26, 13.04 282.77, 85.15 -61.02, -37.96 in-in in 7.292 Saltbr-in 2.733 HRD-in -81.64, -39.67 73.25, -26.34 in-in-out SNCiio in-out ActLoopNT-in 2.805 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.27, 0.25 APE9-dihe-in -89.57, 135.4 APE8-dihe-in -54.02, 135.51 APE8-rot-na 331.24 APE67-dihe-in -70.23, -12.8 -60.25, -35.58 APE12-dist-na 8.547 APE11-dist-na 10.359 APE10-dist-na 7.397 APE9-dist-in 5.49 V804M PTR928 PTR928 XRAY 2.05 0.179 0.229 A 314 276 32 0 0 9 [[724, 1007]] 1.0 6i82 TYR_RET_HUMAN TYR 2.2e-101 344.5 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
6I82B 714 1012 1114.0 H6W:61102 Type1 Inactive DFGin 6.954 13.865 BLAminus -130.06, -175.77 62.79, 72.73 -97.62, 2.52 278.58, 93.96 -55.94, -34.07 in-in in 7.211 Saltbr-in 3.116 HRD-in -79.75, -46.53 78.6, -22.75 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.41, 14.52 APE9-dihe-in -83.53, 127.81 APE8-dihe-in -46.22, 130.06 APE8-rot-na 326.46 APE67-dihe-in -73.49, -7.07 -47.41, -42.33 APE12-dist-na 13.716 APE11-dist-na 9.119 APE10-dist-na 7.734 APE9-dist-in 5.483 V804M PTR928 PTR928 XRAY 2.05 0.179 0.229 B 314 286 13 0 0 0 [[724, 1007]] 1.0 6i82 TYR_RET_HUMAN TYR 2.2e-101 344.5 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
6I83A 705 1013 1114.0 H72:61101 Type1 Inactive DFGin 6.954 14.116 BLAminus -136.61, 173.7 65.09, 71.37 -93.9, 14.87 281.63, 78.76 -60.12, -31.98 in-in in 7.415 Saltbr-in 2.934 HRD-in -67.19, -51.23 82.47, -25.16 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.13, 15.82 APE9-dihe-in -81.5, 130.53 APE8-dihe-in -49.04, 130.82 APE8-rot-na 329.36 APE67-dihe-in -66.77, -10.2 -47.21, -47.52 APE12-dist-na 13.473 APE11-dist-na 9.006 APE10-dist-na 7.667 APE9-dist-in 5.369 V804M PTR905 PTR905 XRAY 1.88 0.208 0.238 A 314 287 22 0 0 0 [[724, 1007]] 1.0 6i83 TYR_RET_HUMAN TYR 2.2e-101 344.5 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
6VHGA 707 1012 1114.0 QX1:1101 Type1 Inactive DFGin 6.696 14.57 BLAminus -131.52, -170.93 57.01, 67.42 -90.26, 7.93 289.76, 85.38 -63.85, -25.23 in-in in 7.767 Saltbr-in 2.819 HRD-in -66.28, -48.33 72.99, -36.21 in-in-out SNCiio in-out ActLoopNT-in 2.789 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.26, -6.31 APE9-dihe-in -96.12, 134.68 APE8-dihe-in -51.97, 125.16 APE8-rot-na 332.2 APE67-dihe-in -68.71, -12.32 -46.83, -47.32 APE12-dist-na 12.133 APE11-dist-na 10.756 APE10-dist-na 6.763 APE9-dist-in 5.417 None PTR905,PTR928 PTR905,PTR928 XRAY 2.303 0.204 0.238 A 311 283 23 0 0 0 [[724, 1007]] 1.0 6vhg TYR_RET_HUMAN TYR 3.9e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
2IVSA 713 1012 1114.0 ACK:63016 Type1 Inactive DFGin 6.783 14.179 BLAminus -136.62, -179.95 61.37, 73.3 -96.71, 13.54 284.89, 83.7 -58.31, -35.12 in-in in 6.822 Saltbr-in 2.724 HRD-in -73.32, -45.65 77.78, -26.26 in-in-out SNCiio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.12, 16.27 APE9-dihe-in -86.42, 135.65 APE8-dihe-in -50.22, 131.78 APE8-rot-na 326.77 APE67-dihe-in -68.23, -10.26 -49.69, -41.68 APE12-dist-na 13.408 APE11-dist-na 9.137 APE10-dist-na 7.359 APE9-dist-in 5.361 None None None XRAY 2.0 0.183 0.229 A 314 284 16 0 0 0 [[724, 1007]] 1.0 2ivs TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
2IVSB 703 1012 1114.0 ACK:63016 Type1 Inactive DFGin 6.78 14.543 BLAminus -130.3, -178.58 63.6, 66.85 -91.03, 11.65 282.25, 80.2 -55.31, -31.74 in-in in 7.174 Saltbr-in 2.861 HRD-in -71.97, -42.82 73.93, -25.74 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.76, 9.86 APE9-dihe-in -84.11, 132.2 APE8-dihe-in -50.29, 130.93 APE8-rot-na 326.96 APE67-dihe-in -73.13, -10.63 -49.04, -38.94 APE12-dist-na 999.0 APE11-dist-na 9.255 APE10-dist-na 7.261 APE9-dist-in 5.327 None None None XRAY 2.0 0.183 0.229 B 314 274 33 0 0 11 [[724, 1007]] 1.0 2ivs TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
2IVUA 703 1012 1114.0 ZD6:63015 Type1 Inactive DFGin 6.687 14.139 BLAminus -133.73, 176.39 56.91, 72.42 -92.01, 6.48 287.74, 90.54 -52.61, -36.06 in-in in 7.509 Saltbr-in 2.697 HRD-in -80.4, -42.15 76.28, -31.91 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.14, 16.52 APE9-dihe-in -91.09, 137.53 APE8-dihe-in -54.45, 140.76 APE8-rot-na 328.3 APE67-dihe-in -85.5, -4.86 -63.16, -25.73 APE12-dist-na 13.614 APE11-dist-na 9.285 APE10-dist-na 7.821 APE9-dist-in 5.522 None PTR905 PTR905 XRAY 2.5 0.193 0.248 A 314 286 23 0 0 0 [[724, 1007]] 1.0 2ivu TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
2X2KA 703 1013 1114.0 X2K:62017 Type1 Inactive DFGin 6.835 13.849 BLAminus -126.8, -166.03 48.44, 88.27 -107.19, 8.07 281.92, 85.32 -50.91, -36.73 in-in in 7.09 Saltbr-in 3.316 HRD-in -90.31, -39.72 77.27, -30.21 in-in-out SNCiio in-out ActLoopNT-in 2.919 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.21, 20.73 APE9-dihe-in -92.62, 132.21 APE8-dihe-in -45.08, 129.34 APE8-rot-na 325.27 APE67-dihe-in -86.86, 1.81 -49.0, -36.28 APE12-dist-na 13.786 APE11-dist-na 9.451 APE10-dist-na 8.013 APE9-dist-in 5.392 None PTR905 PTR905 XRAY 2.6 0.194 0.256 A 314 287 21 0 0 0 [[724, 1007]] 1.0 2x2k TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
2X2LA 703 1010 1114.0 X2L:62015 Type1 Inactive DFGin 6.749 13.803 BLAminus -129.32, -171.58 59.91, 73.29 -95.62, 14.07 289.26, 80.71 -51.35, -44.85 in-in in 7.255 Saltbr-in 2.431 HRD-in -62.71, -48.3 81.07, -29.11 in-in-out SNCiio in-out ActLoopNT-in 2.979 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.87, 19.24 APE9-dihe-in -88.76, 133.69 APE8-dihe-in -43.28, 124.96 APE8-rot-na 327.15 APE67-dihe-in -73.74, -6.59 -46.95, -41.58 APE12-dist-na 13.604 APE11-dist-na 9.148 APE10-dist-na 7.603 APE9-dist-in 5.481 None PTR905 PTR905 XRAY 2.0 0.214 0.269 A 314 285 21 0 0 0 [[724, 1007]] 1.0 2x2l TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
2X2MA 703 1013 1114.0 X2M:62016 Type1 Inactive DFGin 6.849 13.888 BLAminus -132.72, 176.36 64.54, 82.99 -104.43, 14.26 281.7, 84.51 -56.17, -36.08 in-in in 7.065 Saltbr-in 2.79 HRD-in -79.95, -42.92 79.75, -39.82 in-in-out SNCiio in-out ActLoopNT-in 2.944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.3, 19.2 APE9-dihe-in -88.29, 134.7 APE8-dihe-in -47.08, 137.56 APE8-rot-na 326.84 APE67-dihe-in -70.83, -5.51 -64.95, -30.41 APE12-dist-na 13.826 APE11-dist-na 9.372 APE10-dist-na 7.876 APE9-dist-in 5.511 None PTR905 PTR905 XRAY 2.5 0.203 0.242 A 314 284 26 0 0 0 [[724, 1007]] 1.0 2x2m TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
2X2MB 703 1011 1114.0 X2M:62015 Type1 Inactive DFGin 6.778 13.768 BLAminus -134.83, -176.54 54.15, 78.73 -94.9, 13.94 290.94, 81.37 -52.99, -42.66 in-in in 6.983 Saltbr-in 2.659 HRD-in -80.9, -47.45 80.81, -38.31 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.47, 18.49 APE9-dihe-in -91.81, 131.11 APE8-dihe-in -50.05, 139.05 APE8-rot-na 333.62 APE67-dihe-in -74.51, -4.73 -60.97, -30.53 APE12-dist-na 13.669 APE11-dist-na 9.25 APE10-dist-na 7.723 APE9-dist-in 5.52 None PTR905 PTR905 XRAY 2.5 0.203 0.242 B 314 277 29 0 0 0 [[724, 1007]] 1.0 2x2m TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
4CKJA 705 1013 1114.0 ADN:62014 Type1 Inactive DFGin 6.799 14.267 BLAminus -142.57, -173.53 61.96, 74.35 -98.53, 13.01 284.62, 85.56 -60.08, -30.45 in-in in 7.039 Saltbr-in 2.76 HRD-in -74.89, -46.96 77.65, -13.67 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.85, 27.99 APE9-dihe-in -102.95, 135.91 APE8-dihe-in -52.01, 131.39 APE8-rot-na 319.87 APE67-dihe-in -74.49, -6.87 -52.83, -38.38 APE12-dist-na 13.53 APE11-dist-na 9.318 APE10-dist-na 7.901 APE9-dist-in 5.528 None PTR905 PTR905 XRAY 1.65 0.155 0.181 A 314 288 21 0 0 0 [[724, 1007]] 1.0 4ckj TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
6NJAA 705 1013 1114.0 ADE:61101 Type1 Inactive DFGin 6.799 13.878 BLAminus -137.14, 177.68 65.42, 76.1 -98.1, 14.96 280.4, 84.03 -65.23, -23.92 in-in in 7.169 Saltbr-in 2.89 HRD-in -73.14, -47.89 82.54, -25.42 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.72, 15.0 APE9-dihe-in -85.67, 136.78 APE8-dihe-in -51.46, 130.0 APE8-rot-na 328.83 APE67-dihe-in -73.82, -7.14 -46.66, -43.11 APE12-dist-na 13.753 APE11-dist-na 9.353 APE10-dist-na 7.76 APE9-dist-in 5.458 None PTR900,PTR905 PTR900,PTR905 XRAY 1.92 0.188 0.234 A 314 289 20 0 0 0 [[724, 1007]] 1.0 6nja TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7DU9A 714 1011 1114.0 Q4J:61101 Type1 Inactive DFGin 6.949 14.121 BLAminus -130.33, -174.42 58.73, 65.36 -86.19, 8.31 283.62, 87.3 -63.28, -29.26 in-in in 7.298 Saltbr-in 2.844 HRD-in -74.67, -44.9 78.94, -42.52 in-in-out SNCiio in-out ActLoopNT-in 2.862 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.78, 19.67 APE9-dihe-in -82.89, 134.45 APE8-dihe-in -52.33, 137.21 APE8-rot-na 323.27 APE67-dihe-in -68.72, -8.49 -59.25, -37.83 APE12-dist-na 13.541 APE11-dist-na 9.167 APE10-dist-na 7.5 APE9-dist-in 5.474 None None None XRAY 2.31 0.22 0.249 A 314 285 13 0 0 0 [[724, 1007]] 1.0 7du9 TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7DU9B 705 1012 1114.0 Q4J:61101 Type1 Inactive DFGin 6.942 14.815 BLAminus -140.75, -174.14 57.44, 65.56 -90.9, 8.95 281.01, 87.37 -61.32, -27.02 in-in in 7.623 Saltbr-in 2.94 HRD-in -75.71, -46.65 86.04, -41.97 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.69, 12.26 APE9-dihe-in -84.37, 136.33 APE8-dihe-in -56.91, 135.68 APE8-rot-na 327.83 APE67-dihe-in -66.72, -12.27 -52.77, -41.0 APE12-dist-na 12.805 APE11-dist-na 9.585 APE10-dist-na 7.759 APE9-dist-in 5.511 None None None XRAY 2.31 0.22 0.249 B 314 268 36 0 0 10 [[724, 1007]] 1.0 7du9 TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7JU5A 705 1013 1114.0 Q4J:61101 Type1 Inactive DFGin 6.879 14.834 BLAminus -128.61, -171.91 57.52, 65.29 -87.28, 11.68 279.55, 79.31 -66.81, -20.12 in-in in 7.632 Saltbr-in 2.8 HRD-in -84.47, -40.33 77.23, -28.95 in-in-out SNCiio in-out ActLoopNT-in 2.955 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.3, 14.29 APE9-dihe-in -89.88, 135.82 APE8-dihe-in -53.54, 134.95 APE8-rot-na 328.22 APE67-dihe-in -68.32, -11.15 -49.93, -45.95 APE12-dist-na 13.472 APE11-dist-na 9.512 APE10-dist-na 7.586 APE9-dist-in 5.414 None None None XRAY 1.9 0.191 0.247 A 314 282 27 0 0 8 [[724, 1007]] 1.0 7ju5 TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7JU5B 710 1012 1114.0 Q4J:61101 Type1 Inactive DFGin 6.839 14.342 BLAminus -134.43, -173.06 58.09, 64.61 -89.98, 9.88 284.05, 81.83 -62.24, -29.8 in-in in 7.465 Saltbr-in 2.81 HRD-in -72.03, -43.23 72.95, -28.21 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.77, 15.0 APE9-dihe-in -82.46, 132.21 APE8-dihe-in -46.89, 130.57 APE8-rot-na 330.41 APE67-dihe-in -67.96, -11.33 -51.31, -40.09 APE12-dist-na 13.48 APE11-dist-na 9.257 APE10-dist-na 7.587 APE9-dist-in 5.356 None None None XRAY 1.9 0.191 0.247 B 314 290 13 0 0 0 [[724, 1007]] 1.0 7ju5 TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7JU6A 713 1012 1114.0 Q6G:61101 Type1 Inactive DFGin 6.67 14.436 BLAminus -139.89, -172.14 61.42, 74.93 -98.48, 13.7 281.47, 79.28 -58.44, -32.24 in-in in 7.486 Saltbr-in 3.254 HRD-in -72.27, -46.5 78.36, -28.92 in-in-out SNCiio in-out ActLoopNT-in 2.873 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.29, 18.11 APE9-dihe-in -88.63, 134.88 APE8-dihe-in -53.93, 130.96 APE8-rot-na 329.57 APE67-dihe-in -69.22, -8.74 -44.38, -43.95 APE12-dist-na 13.317 APE11-dist-na 9.04 APE10-dist-na 7.465 APE9-dist-in 5.481 None None None XRAY 2.06 0.199 0.249 A 314 288 12 0 0 0 [[724, 1007]] 1.0 7ju6 TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7NZNA 705 1013 1114.0 VJH:61101 Type1 Inactive DFGin 6.512 14.077 BLAminus -134.98, -171.26 55.88, 76.53 -99.5, 16.54 287.75, 81.23 -59.19, -37.46 in-in in 7.368 Saltbr-in 2.913 HRD-in -73.09, -46.32 74.95, -19.06 in-in-out SNCiio in-out ActLoopNT-in 3.092 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -126.97, 31.24 APE9-dihe-in -102.87, 139.72 APE8-dihe-in -53.72, 136.62 APE8-rot-na 332.68 APE67-dihe-in -66.52, -3.64 -57.98, -44.89 APE12-dist-na 14.054 APE11-dist-na 9.609 APE10-dist-na 8.006 APE9-dist-in 5.34 None PTR900,PTR905 PTR900,PTR905 XRAY 2.39 0.215 0.254 A 314 284 23 0 0 0 [[724, 1007]] 1.0 7nzn TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
2IVVA 703 1011 1114.0 PP1:63014 Type1 Inactive DFGin 6.556 14.142 BLAminus -143.26, -177.25 58.28, 69.53 -89.75, 14.97 288.43, 85.58 -63.26, -29.42 in-in in 7.439 Saltbr-in 2.754 HRD-in -77.34, -42.56 72.38, -27.19 in-in-out SNCiio in-out ActLoopNT-in 2.93 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.4, 14.76 APE9-dihe-in -88.35, 135.17 APE8-dihe-in -51.39, 136.04 APE8-rot-na 332.86 APE67-dihe-in -75.15, -7.72 -61.02, -31.23 APE12-dist-na 13.534 APE11-dist-na 9.251 APE10-dist-na 7.7 APE9-dist-in 5.307 None PTR905 PTR905 XRAY 2.25 0.187 0.237 A 314 280 25 0 0 0 [[724, 1007]] 1.0 2ivv TYR_RET_HUMAN TYR 7.1e-101 342.8 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
5FM2A 710 1011 1114.0 PP1:2012 Type1 Inactive DFGin 6.67 14.57 BLAminus -137.31, -177.68 58.64, 81.32 -104.78, 16.87 293.88, 101.57 -64.38, -27.3 in-in in 7.827 Saltbr-in 2.807 HRD-in -87.02, -32.65 62.59, -65.75 in-in-out SNCiio in-out ActLoopNT-in 3.014 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.05, -1.64 APE9-dihe-in -97.33, 131.3 APE8-dihe-in -59.5, 138.73 APE8-rot-na 18.11 APE67-dihe-in -68.33, -17.95 -61.33, -40.61 APE12-dist-na 11.662 APE11-dist-na 10.656 APE10-dist-na 6.834 APE9-dist-in 6.176 None PTR809,PTR905,SEP909,PTR928 PTR809,PTR905,SEP909,PTR928 XRAY 3.3 0.234 0.253 A 355 277 25 0 0 0 [[724, 1007]] 1.0 5fm2 TYR_RET_HUMAN TYR 6.3e-101 343.0 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
5FM3A 707 1011 1114.0 PP1:2012 Type1 Inactive DFGin 6.684 14.734 BLAminus -140.18, -175.86 58.01, 73.86 -96.76, 15.57 293.16, 98.3 -66.18, -20.62 in-in in 7.574 Saltbr-in 3.111 HRD-in -83.6, -39.84 68.93, -52.48 in-in-out SNCiio in-out ActLoopNT-in 2.621 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.52, -0.83 APE9-dihe-in -95.11, 132.08 APE8-dihe-in -57.55, 137.67 APE8-rot-na 15.41 APE67-dihe-in -67.54, -6.44 -62.19, -42.2 APE12-dist-na 11.903 APE11-dist-na 10.803 APE10-dist-na 7.082 APE9-dist-in 5.851 None PTR809,PTR905,SEP909,PTR928 PTR809,PTR905,SEP909,PTR928 XRAY 2.95 0.2 0.224 A 355 280 25 0 0 0 [[724, 1007]] 1.0 5fm3 TYR_RET_HUMAN TYR 6.3e-101 343.0 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
4CKIA 705 1013 1114.0 ADN:62022 Type1 Inactive DFGin 6.668 14.116 BLAminus -140.51, -172.43 59.47, 75.33 -100.17, 17.92 285.5, 88.95 -62.36, -29.86 in-in in 7.147 Saltbr-in 3.078 HRD-in -77.8, -45.32 75.52, -20.59 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.1, 19.65 APE9-dihe-in -92.48, 138.17 APE8-dihe-in -53.68, 134.11 APE8-rot-na 326.66 APE67-dihe-in -73.39, -8.31 -50.86, -43.32 APE12-dist-na 13.614 APE11-dist-na 9.339 APE10-dist-na 7.871 APE9-dist-in 5.238 M918T PTR900,PTR905 PTR900,PTR905 XRAY 2.116 0.158 0.191 A 314 290 19 0 0 0 [[724, 1007]] 1.0 4cki TYR_RET_HUMAN TYR 1.3e-100 342.0 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
6NECA 713 1012 1114.0 XIN:61101 Type1.5_Back Inactive DFGin 6.955 14.218 BLAminus -133.91, -174.29 60.89, 71.58 -95.62, 14.14 281.92, 78.83 -63.28, -30.8 in-in in 7.445 Saltbr-in 2.734 HRD-in -64.75, -44.44 74.89, -24.66 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.85, 14.06 APE9-dihe-in -80.07, 133.09 APE8-dihe-in -50.98, 131.84 APE8-rot-na 329.18 APE67-dihe-in -66.23, -12.23 -51.13, -39.97 APE12-dist-na 13.539 APE11-dist-na 9.165 APE10-dist-na 7.494 APE9-dist-in 5.384 None None None XRAY 1.87 0.196 0.232 A 314 287 13 0 0 0 [[724, 1007]] 1.0 6nec TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
6NECC 705 1012 1114.0 XIN:61102 Type1.5_Back Inactive DFGin 6.911 14.546 BLAminus -127.42, -177.46 57.73, 73.5 -96.06, 13.56 281.45, 72.28 -58.66, -26.62 in-in in 7.651 Saltbr-in 2.626 HRD-in -74.42, -46.81 83.36, -28.28 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.6, 14.75 APE9-dihe-in -87.1, 131.84 APE8-dihe-in -50.39, 132.72 APE8-rot-na 328.71 APE67-dihe-in -69.0, -12.61 -52.04, -41.84 APE12-dist-na 13.852 APE11-dist-na 9.539 APE10-dist-na 7.638 APE9-dist-in 5.471 None None None XRAY 1.87 0.196 0.232 C 314 279 29 0 0 9 [[724, 1007]] 1.0 6nec TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7DUAA 712 1011 1114.0 HJ0:61101 Type1.5_Back Inactive DFGin 7.016 13.814 BLAminus -133.17, -175.88 62.46, 70.06 -88.8, 12.02 286.56, 80.96 -63.0, -32.79 in-in in 7.237 Saltbr-in 2.608 HRD-in -71.94, -44.64 75.36, -32.55 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.88, 16.82 APE9-dihe-in -86.9, 135.07 APE8-dihe-in -52.13, 133.31 APE8-rot-na 327.44 APE67-dihe-in -66.8, -11.83 -51.98, -41.62 APE12-dist-na 13.453 APE11-dist-na 9.058 APE10-dist-na 7.455 APE9-dist-in 5.383 None None None XRAY 1.64 0.192 0.218 A 314 287 13 0 0 0 [[724, 1007]] 1.0 7dua TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7DUAB 705 1012 1114.0 HJ0:61101 Type1.5_Back Inactive DFGin 6.86 13.974 BLAminus -133.96, -176.89 64.96, 70.22 -90.12, 11.04 287.56, 76.53 -62.89, -28.63 in-in in 7.306 Saltbr-in 2.746 HRD-in -70.74, -43.98 77.73, -36.52 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.25, 10.02 APE9-dihe-in -84.68, 132.89 APE8-dihe-in -55.12, 134.64 APE8-rot-na 329.21 APE67-dihe-in -67.4, -15.3 -50.29, -41.81 APE12-dist-na 12.412 APE11-dist-na 9.271 APE10-dist-na 7.235 APE9-dist-in 5.364 None None None XRAY 1.64 0.192 0.218 B 314 269 36 0 0 10 [[724, 1007]] 1.0 7dua TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7RUNA 705 1012 1114.0 7QU:1102 Type1.5_Back Inactive DFGin 6.628 14.248 BLAminus -134.77, -173.78 63.39, 56.13 -81.71, 19.24 291.69, 108.11 -66.54, -40.45 in-in in 7.588 Saltbr-in 3.458 HRD-in -98.1, -27.51 77.75, -68.34 in-in-out SNCiio in-out ActLoopNT-in 2.687 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.35, -14.09 APE9-dihe-in -83.31, 135.75 APE8-dihe-in -58.85, 127.12 APE8-rot-na 17.23 APE67-dihe-in -70.31, -31.91 -52.84, -32.19 APE12-dist-na 11.765 APE11-dist-na 10.714 APE10-dist-na 6.934 APE9-dist-in 6.239 None PTR809,PTR905,SEP909,PTR928 PTR809,PTR905,SEP909,PTR928 XRAY 3.51 0.222 0.247 A 334 287 21 0 0 0 [[724, 1007]] 1.0 7run TYR_RET_HUMAN TYR 5.1e-101 343.3 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7RUNB 706 1012 1114.0 7QU:1102 Type1.5_Back Inactive DFGin 6.479 14.172 BLAminus -134.95, -173.5 63.71, 56.59 -81.67, 19.29 291.63, 107.9 -66.46, -40.71 in-in in 7.592 Saltbr-in 3.385 HRD-in -99.07, -30.7 75.06, -75.74 in-in-out SNCiio in-out ActLoopNT-in 2.704 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.95, -13.05 APE9-dihe-in -82.84, 135.71 APE8-dihe-in -58.94, 126.93 APE8-rot-na 17.11 APE67-dihe-in -69.79, -32.06 -52.79, -32.62 APE12-dist-na 11.867 APE11-dist-na 10.687 APE10-dist-na 6.82 APE9-dist-in 6.591 None PTR809,PTR905,SEP909,PTR928 PTR809,PTR905,SEP909,PTR928 XRAY 3.51 0.222 0.247 B 334 288 19 0 0 0 [[724, 1007]] 1.0 7run TYR_RET_HUMAN TYR 5.1e-101 343.3 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7DU8A 714 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.959 14.089 BLAminus -139.9, -176.36 61.28, 71.22 -96.57, 22.61 290.51, 82.58 -62.34, -43.12 in-in in 7.246 Saltbr-in 2.725 HRD-in -70.49, -42.48 76.18, -46.1 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.78, 19.85 APE9-dihe-in -91.59, 136.68 APE8-dihe-in -57.27, 135.39 APE8-rot-na 326.69 APE67-dihe-in -68.65, -17.13 -56.96, -36.43 APE12-dist-na 13.472 APE11-dist-na 9.218 APE10-dist-na 7.3 APE9-dist-in 5.634 None None None XRAY 2.75 0.217 0.277 A 314 286 13 0 0 0 [[724, 1007]] 1.0 7du8 TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7DU8B 705 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.866 14.457 BLAminus -139.37, -177.62 63.4, 72.86 -98.32, 23.3 293.23, 81.57 -64.12, -44.29 in-in in 7.349 Saltbr-in 3.227 HRD-in -70.76, -41.16 77.27, -46.88 in-in-out SNCiio in-out ActLoopNT-in 2.948 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.72, 24.05 APE9-dihe-in -92.66, 135.69 APE8-dihe-in -57.1, 135.94 APE8-rot-na 330.01 APE67-dihe-in -67.74, -17.88 -57.22, -36.2 APE12-dist-na 12.963 APE11-dist-na 8.955 APE10-dist-na 7.341 APE9-dist-in 5.668 None None None XRAY 2.75 0.217 0.277 B 314 274 31 0 0 10 [[724, 1007]] 1.0 7du8 TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
7JU6B 705 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.853 14.558 BLAminus -133.87, -179.77 59.88, 75.8 -96.18, 17.81 292.2, 77.2 -56.92, -30.18 in-in in 7.676 Saltbr-in 2.717 HRD-in -72.4, -43.27 78.98, -30.91 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.34, 21.56 APE9-dihe-in -92.4, 131.54 APE8-dihe-in -51.97, 128.7 APE8-rot-na 329.4 APE67-dihe-in -67.8, -13.47 -45.61, -41.79 APE12-dist-na 13.246 APE11-dist-na 9.219 APE10-dist-na 7.607 APE9-dist-in 5.405 None None None XRAY 2.06 0.199 0.249 B 314 286 22 0 0 9 [[724, 1007]] 1.0 7ju6 TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret

TYR_RET (Proto-oncogene tyrosine-protein kinase receptor Ret)

Total number of chains: 38
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 38 100.0% AF-P07949-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RET_HUMAN AF-P07949-K1A P07949 716 1015 1114.0 No_ligand No_ligand Active DFGin 6.828 14.036 BLAminus -143.32, 176.07 65.43, 64.62 -86.23, 13.69 292.95, 85.62 -60.38, -34.34 in-in in 7.648 Saltbr-in 2.599 HRD-in -70.64, -41.86 68.21, -20.18 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.53, 146.83 APE9-dihe-in -136.18, 140.71 APE8-dihe-in -80.57, 71.62 APE8-rot-na 35.04 APE67-dihe-in -72.87, -15.17 -45.11, -40.91 APE12-dist-na 14.531 APE11-dist-na 10.052 APE10-dist-na 10.409 APE9-dist-in 7.076 None None None AF2 -1.0 1.0 1.0 A 300 300 0 0 0 0 [[724, 1007]] 1.0 AF-P07949-K1 Homo sapiens TYR_RET_HUMAN TYR 3.4e-101 343.8 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN AF-P07949-K3A P07949 716 1015 1114.0 No_ligand No_ligand Active DFGin 6.685 13.739 BLAminus -145.92, 179.52 65.99, 59.7 -79.85, 12.57 294.52, 86.95 -60.42, -32.03 in-in in 7.693 Saltbr-in 2.616 HRD-in -73.1, -42.04 65.97, -12.14 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -52.53, 134.45 APE9-dihe-in -131.95, 144.91 APE8-dihe-in -82.65, 62.78 APE8-rot-na 36.76 APE67-dihe-in -71.83, -7.8 -41.21, -43.71 APE12-dist-na 14.348 APE11-dist-na 10.528 APE10-dist-na 10.185 APE9-dist-in 6.907 None None None AF2 -1.0 1.0 1.0 A 300 300 0 0 0 0 [[724, 1007]] 1.0 AF-P07949-K3 Homo sapiens TYR_RET_HUMAN TYR 3.4e-101 343.8 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 2IVTA P07949 703 1012 1114.0 AMP:63015 ATPlike Inactive DFGin 6.582 14.046 BLAminus -135.2, 176.38 61.74, 80.34 -103.81, 14.47 281.76, 90.09 -59.35, -34.21 in-in in 7.234 Saltbr-in 2.737 HRD-in -77.56, -43.39 78.85, -29.33 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.53, 33.76 APE9-dihe-in -110.13, 138.63 APE8-dihe-in -57.62, 135.06 APE8-rot-na 332.88 APE67-dihe-in -80.74, -4.59 -59.92, -27.73 APE12-dist-na 13.764 APE11-dist-na 9.424 APE10-dist-na 8.046 APE9-dist-in 5.596 None PTR905 PTR905 XRAY 2.6 0.187 0.249 A 314 286 21 0 0 0 [[724, 1007]] 1.0 2ivt Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 6NE7A P07949 705 1013 1114.0 AMP:61103 ATPlike Inactive DFGin 6.727 14.262 BLAminus -136.24, -174.2 57.88, 74.27 -97.52, 17.22 284.41, 79.78 -59.81, -27.59 in-in in 7.093 Saltbr-in 2.608 HRD-in -73.16, -50.61 79.87, -20.93 in-in-out SNCiio in-out ActLoopNT-in 2.941 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.57, 19.09 APE9-dihe-in -87.06, 133.71 APE8-dihe-in -50.0, 126.08 APE8-rot-na 331.41 APE67-dihe-in -72.8, -6.12 -42.6, -44.71 APE12-dist-na 13.52 APE11-dist-na 9.107 APE10-dist-na 7.618 APE9-dist-in 5.218 G810A PTR900,PTR905 PTR900,PTR905 XRAY 1.99 0.206 0.249 A 314 290 19 0 0 0 [[724, 1007]] 1.0 6ne7 Homo sapiens TYR_RET_HUMAN TYR 7.8e-100 339.4 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 5AMNA P07949 705 1010 1114.0 DTQ:62018 Type1 Inactive DFGin 6.924 14.481 BLAminus -129.35, -171.61 56.5, 78.55 -104.27, 12.34 284.28, 84.08 -59.73, -21.54 in-in in 7.48 Saltbr-in 2.779 HRD-in -71.89, -48.34 77.05, -6.64 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.95, 28.12 APE9-dihe-in -97.69, 135.77 APE8-dihe-in -52.26, 130.31 APE8-rot-na 328.98 APE67-dihe-in -75.47, -2.3 -49.07, -44.55 APE12-dist-na 13.744 APE11-dist-na 9.273 APE10-dist-na 8.313 APE9-dist-in 5.528 None PTR900,PTR905 PTR900,PTR905 XRAY 2.57 0.186 0.237 A 299 284 6 0 0 0 [[724, 1007]] 1.0 5amn Homo sapiens TYR_RET_HUMAN TYR 2.4e-101 344.3 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 6FEKA P07949 705 1010 1114.0 ADN:61104 Type1 Inactive DFGin 6.767 13.821 BLAminus -141.99, -171.41 59.54, 71.43 -98.37, 12.19 284.75, 93.0 -64.4, -26.64 in-none in 7.246 Saltbr-none 999.0 HRD-in -77.44, -40.12 73.87, -24.59 none-in-out SNCnio in-out ActLoopNT-in 2.971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.75, 17.41 APE9-dihe-in -84.07, 140.52 APE8-dihe-in -58.1, 137.81 APE8-rot-na 331.87 APE67-dihe-in -76.24, -0.91 -55.46, -40.98 APE12-dist-na 13.861 APE11-dist-na 9.442 APE10-dist-na 7.876 APE9-dist-in 5.294 S904F PTR900,PTR905 PTR900,PTR905 XRAY 2.3 0.203 0.244 A 299 291 0 0 0 0 [[724, 1007]] 1.0 6fek Homo sapiens TYR_RET_HUMAN TYR 8.2e-101 342.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 6I82A P07949 705 1012 1114.0 H6W:61101 Type1 Inactive DFGin 6.849 14.471 BLAminus -128.14, -174.21 67.72, 61.92 -90.26, 13.04 282.77, 85.15 -61.02, -37.96 in-in in 7.292 Saltbr-in 2.733 HRD-in -81.64, -39.67 73.25, -26.34 in-in-out SNCiio in-out ActLoopNT-in 2.805 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -116.27, 0.25 APE9-dihe-in -89.57, 135.4 APE8-dihe-in -54.02, 135.51 APE8-rot-na 331.24 APE67-dihe-in -70.23, -12.8 -60.25, -35.58 APE12-dist-na 8.547 APE11-dist-na 10.359 APE10-dist-na 7.397 APE9-dist-in 5.49 V804M PTR928 PTR928 XRAY 2.05 0.179 0.229 A 314 276 32 0 0 9 [[724, 1007]] 1.0 6i82 Homo sapiens TYR_RET_HUMAN TYR 2.2e-101 344.5 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 6I82B P07949 714 1012 1114.0 H6W:61102 Type1 Inactive DFGin 6.954 13.865 BLAminus -130.06, -175.77 62.79, 72.73 -97.62, 2.52 278.58, 93.96 -55.94, -34.07 in-in in 7.211 Saltbr-in 3.116 HRD-in -79.75, -46.53 78.6, -22.75 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.41, 14.52 APE9-dihe-in -83.53, 127.81 APE8-dihe-in -46.22, 130.06 APE8-rot-na 326.46 APE67-dihe-in -73.49, -7.07 -47.41, -42.33 APE12-dist-na 13.716 APE11-dist-na 9.119 APE10-dist-na 7.734 APE9-dist-in 5.483 V804M PTR928 PTR928 XRAY 2.05 0.179 0.229 B 314 286 13 0 0 0 [[724, 1007]] 1.0 6i82 Homo sapiens TYR_RET_HUMAN TYR 2.2e-101 344.5 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 6I83A P07949 705 1013 1114.0 H72:61101 Type1 Inactive DFGin 6.954 14.116 BLAminus -136.61, 173.7 65.09, 71.37 -93.9, 14.87 281.63, 78.76 -60.12, -31.98 in-in in 7.415 Saltbr-in 2.934 HRD-in -67.19, -51.23 82.47, -25.16 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.13, 15.82 APE9-dihe-in -81.5, 130.53 APE8-dihe-in -49.04, 130.82 APE8-rot-na 329.36 APE67-dihe-in -66.77, -10.2 -47.21, -47.52 APE12-dist-na 13.473 APE11-dist-na 9.006 APE10-dist-na 7.667 APE9-dist-in 5.369 V804M PTR905 PTR905 XRAY 1.88 0.208 0.238 A 314 287 22 0 0 0 [[724, 1007]] 1.0 6i83 Homo sapiens TYR_RET_HUMAN TYR 2.2e-101 344.5 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 6VHGA P07949 707 1012 1114.0 QX1:1101 Type1 Inactive DFGin 6.696 14.57 BLAminus -131.52, -170.93 57.01, 67.42 -90.26, 7.93 289.76, 85.38 -63.85, -25.23 in-in in 7.767 Saltbr-in 2.819 HRD-in -66.28, -48.33 72.99, -36.21 in-in-out SNCiio in-out ActLoopNT-in 2.789 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.26, -6.31 APE9-dihe-in -96.12, 134.68 APE8-dihe-in -51.97, 125.16 APE8-rot-na 332.2 APE67-dihe-in -68.71, -12.32 -46.83, -47.32 APE12-dist-na 12.133 APE11-dist-na 10.756 APE10-dist-na 6.763 APE9-dist-in 5.417 None PTR905,PTR928 PTR905,PTR928 XRAY 2.303 0.204 0.238 A 311 283 23 0 0 0 [[724, 1007]] 1.0 6vhg Homo sapiens TYR_RET_HUMAN TYR 3.9e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 2IVSA P07949 713 1012 1114.0 ACK:63016 Type1 Inactive DFGin 6.783 14.179 BLAminus -136.62, -179.95 61.37, 73.3 -96.71, 13.54 284.89, 83.7 -58.31, -35.12 in-in in 6.822 Saltbr-in 2.724 HRD-in -73.32, -45.65 77.78, -26.26 in-in-out SNCiio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.12, 16.27 APE9-dihe-in -86.42, 135.65 APE8-dihe-in -50.22, 131.78 APE8-rot-na 326.77 APE67-dihe-in -68.23, -10.26 -49.69, -41.68 APE12-dist-na 13.408 APE11-dist-na 9.137 APE10-dist-na 7.359 APE9-dist-in 5.361 None None None XRAY 2.0 0.183 0.229 A 314 284 16 0 0 0 [[724, 1007]] 1.0 2ivs Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 2IVSB P07949 703 1012 1114.0 ACK:63016 Type1 Inactive DFGin 6.78 14.543 BLAminus -130.3, -178.58 63.6, 66.85 -91.03, 11.65 282.25, 80.2 -55.31, -31.74 in-in in 7.174 Saltbr-in 2.861 HRD-in -71.97, -42.82 73.93, -25.74 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.76, 9.86 APE9-dihe-in -84.11, 132.2 APE8-dihe-in -50.29, 130.93 APE8-rot-na 326.96 APE67-dihe-in -73.13, -10.63 -49.04, -38.94 APE12-dist-na 999.0 APE11-dist-na 9.255 APE10-dist-na 7.261 APE9-dist-in 5.327 None None None XRAY 2.0 0.183 0.229 B 314 274 33 0 0 11 [[724, 1007]] 1.0 2ivs Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 2IVUA P07949 703 1012 1114.0 ZD6:63015 Type1 Inactive DFGin 6.687 14.139 BLAminus -133.73, 176.39 56.91, 72.42 -92.01, 6.48 287.74, 90.54 -52.61, -36.06 in-in in 7.509 Saltbr-in 2.697 HRD-in -80.4, -42.15 76.28, -31.91 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.14, 16.52 APE9-dihe-in -91.09, 137.53 APE8-dihe-in -54.45, 140.76 APE8-rot-na 328.3 APE67-dihe-in -85.5, -4.86 -63.16, -25.73 APE12-dist-na 13.614 APE11-dist-na 9.285 APE10-dist-na 7.821 APE9-dist-in 5.522 None PTR905 PTR905 XRAY 2.5 0.193 0.248 A 314 286 23 0 0 0 [[724, 1007]] 1.0 2ivu Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 2X2KA P07949 703 1013 1114.0 X2K:62017 Type1 Inactive DFGin 6.835 13.849 BLAminus -126.8, -166.03 48.44, 88.27 -107.19, 8.07 281.92, 85.32 -50.91, -36.73 in-in in 7.09 Saltbr-in 3.316 HRD-in -90.31, -39.72 77.27, -30.21 in-in-out SNCiio in-out ActLoopNT-in 2.919 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.21, 20.73 APE9-dihe-in -92.62, 132.21 APE8-dihe-in -45.08, 129.34 APE8-rot-na 325.27 APE67-dihe-in -86.86, 1.81 -49.0, -36.28 APE12-dist-na 13.786 APE11-dist-na 9.451 APE10-dist-na 8.013 APE9-dist-in 5.392 None PTR905 PTR905 XRAY 2.6 0.194 0.256 A 314 287 21 0 0 0 [[724, 1007]] 1.0 2x2k Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 2X2LA P07949 703 1010 1114.0 X2L:62015 Type1 Inactive DFGin 6.749 13.803 BLAminus -129.32, -171.58 59.91, 73.29 -95.62, 14.07 289.26, 80.71 -51.35, -44.85 in-in in 7.255 Saltbr-in 2.431 HRD-in -62.71, -48.3 81.07, -29.11 in-in-out SNCiio in-out ActLoopNT-in 2.979 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.87, 19.24 APE9-dihe-in -88.76, 133.69 APE8-dihe-in -43.28, 124.96 APE8-rot-na 327.15 APE67-dihe-in -73.74, -6.59 -46.95, -41.58 APE12-dist-na 13.604 APE11-dist-na 9.148 APE10-dist-na 7.603 APE9-dist-in 5.481 None PTR905 PTR905 XRAY 2.0 0.214 0.269 A 314 285 21 0 0 0 [[724, 1007]] 1.0 2x2l Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 2X2MA P07949 703 1013 1114.0 X2M:62016 Type1 Inactive DFGin 6.849 13.888 BLAminus -132.72, 176.36 64.54, 82.99 -104.43, 14.26 281.7, 84.51 -56.17, -36.08 in-in in 7.065 Saltbr-in 2.79 HRD-in -79.95, -42.92 79.75, -39.82 in-in-out SNCiio in-out ActLoopNT-in 2.944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.3, 19.2 APE9-dihe-in -88.29, 134.7 APE8-dihe-in -47.08, 137.56 APE8-rot-na 326.84 APE67-dihe-in -70.83, -5.51 -64.95, -30.41 APE12-dist-na 13.826 APE11-dist-na 9.372 APE10-dist-na 7.876 APE9-dist-in 5.511 None PTR905 PTR905 XRAY 2.5 0.203 0.242 A 314 284 26 0 0 0 [[724, 1007]] 1.0 2x2m Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 2X2MB P07949 703 1011 1114.0 X2M:62015 Type1 Inactive DFGin 6.778 13.768 BLAminus -134.83, -176.54 54.15, 78.73 -94.9, 13.94 290.94, 81.37 -52.99, -42.66 in-in in 6.983 Saltbr-in 2.659 HRD-in -80.9, -47.45 80.81, -38.31 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.47, 18.49 APE9-dihe-in -91.81, 131.11 APE8-dihe-in -50.05, 139.05 APE8-rot-na 333.62 APE67-dihe-in -74.51, -4.73 -60.97, -30.53 APE12-dist-na 13.669 APE11-dist-na 9.25 APE10-dist-na 7.723 APE9-dist-in 5.52 None PTR905 PTR905 XRAY 2.5 0.203 0.242 B 314 277 29 0 0 0 [[724, 1007]] 1.0 2x2m Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 4CKJA P07949 705 1013 1114.0 ADN:62014 Type1 Inactive DFGin 6.799 14.267 BLAminus -142.57, -173.53 61.96, 74.35 -98.53, 13.01 284.62, 85.56 -60.08, -30.45 in-in in 7.039 Saltbr-in 2.76 HRD-in -74.89, -46.96 77.65, -13.67 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.85, 27.99 APE9-dihe-in -102.95, 135.91 APE8-dihe-in -52.01, 131.39 APE8-rot-na 319.87 APE67-dihe-in -74.49, -6.87 -52.83, -38.38 APE12-dist-na 13.53 APE11-dist-na 9.318 APE10-dist-na 7.901 APE9-dist-in 5.528 None PTR905 PTR905 XRAY 1.65 0.155 0.181 A 314 288 21 0 0 0 [[724, 1007]] 1.0 4ckj Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 6NJAA P07949 705 1013 1114.0 ADE:61101 Type1 Inactive DFGin 6.799 13.878 BLAminus -137.14, 177.68 65.42, 76.1 -98.1, 14.96 280.4, 84.03 -65.23, -23.92 in-in in 7.169 Saltbr-in 2.89 HRD-in -73.14, -47.89 82.54, -25.42 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.72, 15.0 APE9-dihe-in -85.67, 136.78 APE8-dihe-in -51.46, 130.0 APE8-rot-na 328.83 APE67-dihe-in -73.82, -7.14 -46.66, -43.11 APE12-dist-na 13.753 APE11-dist-na 9.353 APE10-dist-na 7.76 APE9-dist-in 5.458 None PTR900,PTR905 PTR900,PTR905 XRAY 1.92 0.188 0.234 A 314 289 20 0 0 0 [[724, 1007]] 1.0 6nja Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7DU9A P07949 714 1011 1114.0 Q4J:61101 Type1 Inactive DFGin 6.949 14.121 BLAminus -130.33, -174.42 58.73, 65.36 -86.19, 8.31 283.62, 87.3 -63.28, -29.26 in-in in 7.298 Saltbr-in 2.844 HRD-in -74.67, -44.9 78.94, -42.52 in-in-out SNCiio in-out ActLoopNT-in 2.862 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.78, 19.67 APE9-dihe-in -82.89, 134.45 APE8-dihe-in -52.33, 137.21 APE8-rot-na 323.27 APE67-dihe-in -68.72, -8.49 -59.25, -37.83 APE12-dist-na 13.541 APE11-dist-na 9.167 APE10-dist-na 7.5 APE9-dist-in 5.474 None None None XRAY 2.31 0.22 0.249 A 314 285 13 0 0 0 [[724, 1007]] 1.0 7du9 Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7DU9B P07949 705 1012 1114.0 Q4J:61101 Type1 Inactive DFGin 6.942 14.815 BLAminus -140.75, -174.14 57.44, 65.56 -90.9, 8.95 281.01, 87.37 -61.32, -27.02 in-in in 7.623 Saltbr-in 2.94 HRD-in -75.71, -46.65 86.04, -41.97 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.69, 12.26 APE9-dihe-in -84.37, 136.33 APE8-dihe-in -56.91, 135.68 APE8-rot-na 327.83 APE67-dihe-in -66.72, -12.27 -52.77, -41.0 APE12-dist-na 12.805 APE11-dist-na 9.585 APE10-dist-na 7.759 APE9-dist-in 5.511 None None None XRAY 2.31 0.22 0.249 B 314 268 36 0 0 10 [[724, 1007]] 1.0 7du9 Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7JU5A P07949 705 1013 1114.0 Q4J:61101 Type1 Inactive DFGin 6.879 14.834 BLAminus -128.61, -171.91 57.52, 65.29 -87.28, 11.68 279.55, 79.31 -66.81, -20.12 in-in in 7.632 Saltbr-in 2.8 HRD-in -84.47, -40.33 77.23, -28.95 in-in-out SNCiio in-out ActLoopNT-in 2.955 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.3, 14.29 APE9-dihe-in -89.88, 135.82 APE8-dihe-in -53.54, 134.95 APE8-rot-na 328.22 APE67-dihe-in -68.32, -11.15 -49.93, -45.95 APE12-dist-na 13.472 APE11-dist-na 9.512 APE10-dist-na 7.586 APE9-dist-in 5.414 None None None XRAY 1.9 0.191 0.247 A 314 282 27 0 0 8 [[724, 1007]] 1.0 7ju5 Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7JU5B P07949 710 1012 1114.0 Q4J:61101 Type1 Inactive DFGin 6.839 14.342 BLAminus -134.43, -173.06 58.09, 64.61 -89.98, 9.88 284.05, 81.83 -62.24, -29.8 in-in in 7.465 Saltbr-in 2.81 HRD-in -72.03, -43.23 72.95, -28.21 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.77, 15.0 APE9-dihe-in -82.46, 132.21 APE8-dihe-in -46.89, 130.57 APE8-rot-na 330.41 APE67-dihe-in -67.96, -11.33 -51.31, -40.09 APE12-dist-na 13.48 APE11-dist-na 9.257 APE10-dist-na 7.587 APE9-dist-in 5.356 None None None XRAY 1.9 0.191 0.247 B 314 290 13 0 0 0 [[724, 1007]] 1.0 7ju5 Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7JU6A P07949 713 1012 1114.0 Q6G:61101 Type1 Inactive DFGin 6.67 14.436 BLAminus -139.89, -172.14 61.42, 74.93 -98.48, 13.7 281.47, 79.28 -58.44, -32.24 in-in in 7.486 Saltbr-in 3.254 HRD-in -72.27, -46.5 78.36, -28.92 in-in-out SNCiio in-out ActLoopNT-in 2.873 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.29, 18.11 APE9-dihe-in -88.63, 134.88 APE8-dihe-in -53.93, 130.96 APE8-rot-na 329.57 APE67-dihe-in -69.22, -8.74 -44.38, -43.95 APE12-dist-na 13.317 APE11-dist-na 9.04 APE10-dist-na 7.465 APE9-dist-in 5.481 None None None XRAY 2.06 0.199 0.249 A 314 288 12 0 0 0 [[724, 1007]] 1.0 7ju6 Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7NZNA P07949 705 1013 1114.0 VJH:61101 Type1 Inactive DFGin 6.512 14.077 BLAminus -134.98, -171.26 55.88, 76.53 -99.5, 16.54 287.75, 81.23 -59.19, -37.46 in-in in 7.368 Saltbr-in 2.913 HRD-in -73.09, -46.32 74.95, -19.06 in-in-out SNCiio in-out ActLoopNT-in 3.092 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -126.97, 31.24 APE9-dihe-in -102.87, 139.72 APE8-dihe-in -53.72, 136.62 APE8-rot-na 332.68 APE67-dihe-in -66.52, -3.64 -57.98, -44.89 APE12-dist-na 14.054 APE11-dist-na 9.609 APE10-dist-na 8.006 APE9-dist-in 5.34 None PTR900,PTR905 PTR900,PTR905 XRAY 2.39 0.215 0.254 A 314 284 23 0 0 0 [[724, 1007]] 1.0 7nzn Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 2IVVA P07949 703 1011 1114.0 PP1:63014 Type1 Inactive DFGin 6.556 14.142 BLAminus -143.26, -177.25 58.28, 69.53 -89.75, 14.97 288.43, 85.58 -63.26, -29.42 in-in in 7.439 Saltbr-in 2.754 HRD-in -77.34, -42.56 72.38, -27.19 in-in-out SNCiio in-out ActLoopNT-in 2.93 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.4, 14.76 APE9-dihe-in -88.35, 135.17 APE8-dihe-in -51.39, 136.04 APE8-rot-na 332.86 APE67-dihe-in -75.15, -7.72 -61.02, -31.23 APE12-dist-na 13.534 APE11-dist-na 9.251 APE10-dist-na 7.7 APE9-dist-in 5.307 None PTR905 PTR905 XRAY 2.25 0.187 0.237 A 314 280 25 0 0 0 [[724, 1007]] 1.0 2ivv Homo sapiens TYR_RET_HUMAN TYR 7.1e-101 342.8 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 5FM2A P07949 710 1011 1114.0 PP1:2012 Type1 Inactive DFGin 6.67 14.57 BLAminus -137.31, -177.68 58.64, 81.32 -104.78, 16.87 293.88, 101.57 -64.38, -27.3 in-in in 7.827 Saltbr-in 2.807 HRD-in -87.02, -32.65 62.59, -65.75 in-in-out SNCiio in-out ActLoopNT-in 3.014 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.05, -1.64 APE9-dihe-in -97.33, 131.3 APE8-dihe-in -59.5, 138.73 APE8-rot-na 18.11 APE67-dihe-in -68.33, -17.95 -61.33, -40.61 APE12-dist-na 11.662 APE11-dist-na 10.656 APE10-dist-na 6.834 APE9-dist-in 6.176 None PTR809,PTR905,SEP909,PTR928 PTR809,PTR905,SEP909,PTR928 XRAY 3.3 0.234 0.253 A 355 277 25 0 0 0 [[724, 1007]] 1.0 5fm2 Homo sapiens TYR_RET_HUMAN TYR 6.3e-101 343.0 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 5FM3A P07949 707 1011 1114.0 PP1:2012 Type1 Inactive DFGin 6.684 14.734 BLAminus -140.18, -175.86 58.01, 73.86 -96.76, 15.57 293.16, 98.3 -66.18, -20.62 in-in in 7.574 Saltbr-in 3.111 HRD-in -83.6, -39.84 68.93, -52.48 in-in-out SNCiio in-out ActLoopNT-in 2.621 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.52, -0.83 APE9-dihe-in -95.11, 132.08 APE8-dihe-in -57.55, 137.67 APE8-rot-na 15.41 APE67-dihe-in -67.54, -6.44 -62.19, -42.2 APE12-dist-na 11.903 APE11-dist-na 10.803 APE10-dist-na 7.082 APE9-dist-in 5.851 None PTR809,PTR905,SEP909,PTR928 PTR809,PTR905,SEP909,PTR928 XRAY 2.95 0.2 0.224 A 355 280 25 0 0 0 [[724, 1007]] 1.0 5fm3 Homo sapiens TYR_RET_HUMAN TYR 6.3e-101 343.0 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 4CKIA P07949 705 1013 1114.0 ADN:62022 Type1 Inactive DFGin 6.668 14.116 BLAminus -140.51, -172.43 59.47, 75.33 -100.17, 17.92 285.5, 88.95 -62.36, -29.86 in-in in 7.147 Saltbr-in 3.078 HRD-in -77.8, -45.32 75.52, -20.59 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.1, 19.65 APE9-dihe-in -92.48, 138.17 APE8-dihe-in -53.68, 134.11 APE8-rot-na 326.66 APE67-dihe-in -73.39, -8.31 -50.86, -43.32 APE12-dist-na 13.614 APE11-dist-na 9.339 APE10-dist-na 7.871 APE9-dist-in 5.238 M918T PTR900,PTR905 PTR900,PTR905 XRAY 2.116 0.158 0.191 A 314 290 19 0 0 0 [[724, 1007]] 1.0 4cki Homo sapiens TYR_RET_HUMAN TYR 1.3e-100 342.0 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 6NECA P07949 713 1012 1114.0 XIN:61101 Type1.5_Back Inactive DFGin 6.955 14.218 BLAminus -133.91, -174.29 60.89, 71.58 -95.62, 14.14 281.92, 78.83 -63.28, -30.8 in-in in 7.445 Saltbr-in 2.734 HRD-in -64.75, -44.44 74.89, -24.66 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.85, 14.06 APE9-dihe-in -80.07, 133.09 APE8-dihe-in -50.98, 131.84 APE8-rot-na 329.18 APE67-dihe-in -66.23, -12.23 -51.13, -39.97 APE12-dist-na 13.539 APE11-dist-na 9.165 APE10-dist-na 7.494 APE9-dist-in 5.384 None None None XRAY 1.87 0.196 0.232 A 314 287 13 0 0 0 [[724, 1007]] 1.0 6nec Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 6NECC P07949 705 1012 1114.0 XIN:61102 Type1.5_Back Inactive DFGin 6.911 14.546 BLAminus -127.42, -177.46 57.73, 73.5 -96.06, 13.56 281.45, 72.28 -58.66, -26.62 in-in in 7.651 Saltbr-in 2.626 HRD-in -74.42, -46.81 83.36, -28.28 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.6, 14.75 APE9-dihe-in -87.1, 131.84 APE8-dihe-in -50.39, 132.72 APE8-rot-na 328.71 APE67-dihe-in -69.0, -12.61 -52.04, -41.84 APE12-dist-na 13.852 APE11-dist-na 9.539 APE10-dist-na 7.638 APE9-dist-in 5.471 None None None XRAY 1.87 0.196 0.232 C 314 279 29 0 0 9 [[724, 1007]] 1.0 6nec Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7DUAA P07949 712 1011 1114.0 HJ0:61101 Type1.5_Back Inactive DFGin 7.016 13.814 BLAminus -133.17, -175.88 62.46, 70.06 -88.8, 12.02 286.56, 80.96 -63.0, -32.79 in-in in 7.237 Saltbr-in 2.608 HRD-in -71.94, -44.64 75.36, -32.55 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.88, 16.82 APE9-dihe-in -86.9, 135.07 APE8-dihe-in -52.13, 133.31 APE8-rot-na 327.44 APE67-dihe-in -66.8, -11.83 -51.98, -41.62 APE12-dist-na 13.453 APE11-dist-na 9.058 APE10-dist-na 7.455 APE9-dist-in 5.383 None None None XRAY 1.64 0.192 0.218 A 314 287 13 0 0 0 [[724, 1007]] 1.0 7dua Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7DUAB P07949 705 1012 1114.0 HJ0:61101 Type1.5_Back Inactive DFGin 6.86 13.974 BLAminus -133.96, -176.89 64.96, 70.22 -90.12, 11.04 287.56, 76.53 -62.89, -28.63 in-in in 7.306 Saltbr-in 2.746 HRD-in -70.74, -43.98 77.73, -36.52 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.25, 10.02 APE9-dihe-in -84.68, 132.89 APE8-dihe-in -55.12, 134.64 APE8-rot-na 329.21 APE67-dihe-in -67.4, -15.3 -50.29, -41.81 APE12-dist-na 12.412 APE11-dist-na 9.271 APE10-dist-na 7.235 APE9-dist-in 5.364 None None None XRAY 1.64 0.192 0.218 B 314 269 36 0 0 10 [[724, 1007]] 1.0 7dua Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7RUNA P07949 705 1012 1114.0 7QU:1102 Type1.5_Back Inactive DFGin 6.628 14.248 BLAminus -134.77, -173.78 63.39, 56.13 -81.71, 19.24 291.69, 108.11 -66.54, -40.45 in-in in 7.588 Saltbr-in 3.458 HRD-in -98.1, -27.51 77.75, -68.34 in-in-out SNCiio in-out ActLoopNT-in 2.687 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.35, -14.09 APE9-dihe-in -83.31, 135.75 APE8-dihe-in -58.85, 127.12 APE8-rot-na 17.23 APE67-dihe-in -70.31, -31.91 -52.84, -32.19 APE12-dist-na 11.765 APE11-dist-na 10.714 APE10-dist-na 6.934 APE9-dist-in 6.239 None PTR809,PTR905,SEP909,PTR928 PTR809,PTR905,SEP909,PTR928 XRAY 3.51 0.222 0.247 A 334 287 21 0 0 0 [[724, 1007]] 1.0 7run Homo sapiens TYR_RET_HUMAN TYR 5.1e-101 343.3 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7RUNB P07949 706 1012 1114.0 7QU:1102 Type1.5_Back Inactive DFGin 6.479 14.172 BLAminus -134.95, -173.5 63.71, 56.59 -81.67, 19.29 291.63, 107.9 -66.46, -40.71 in-in in 7.592 Saltbr-in 3.385 HRD-in -99.07, -30.7 75.06, -75.74 in-in-out SNCiio in-out ActLoopNT-in 2.704 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.95, -13.05 APE9-dihe-in -82.84, 135.71 APE8-dihe-in -58.94, 126.93 APE8-rot-na 17.11 APE67-dihe-in -69.79, -32.06 -52.79, -32.62 APE12-dist-na 11.867 APE11-dist-na 10.687 APE10-dist-na 6.82 APE9-dist-in 6.591 None PTR809,PTR905,SEP909,PTR928 PTR809,PTR905,SEP909,PTR928 XRAY 3.51 0.222 0.247 B 334 288 19 0 0 0 [[724, 1007]] 1.0 7run Homo sapiens TYR_RET_HUMAN TYR 5.1e-101 343.3 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7DU8A P07949 714 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.959 14.089 BLAminus -139.9, -176.36 61.28, 71.22 -96.57, 22.61 290.51, 82.58 -62.34, -43.12 in-in in 7.246 Saltbr-in 2.725 HRD-in -70.49, -42.48 76.18, -46.1 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.78, 19.85 APE9-dihe-in -91.59, 136.68 APE8-dihe-in -57.27, 135.39 APE8-rot-na 326.69 APE67-dihe-in -68.65, -17.13 -56.96, -36.43 APE12-dist-na 13.472 APE11-dist-na 9.218 APE10-dist-na 7.3 APE9-dist-in 5.634 None None None XRAY 2.75 0.217 0.277 A 314 286 13 0 0 0 [[724, 1007]] 1.0 7du8 Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7DU8B P07949 705 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.866 14.457 BLAminus -139.37, -177.62 63.4, 72.86 -98.32, 23.3 293.23, 81.57 -64.12, -44.29 in-in in 7.349 Saltbr-in 3.227 HRD-in -70.76, -41.16 77.27, -46.88 in-in-out SNCiio in-out ActLoopNT-in 2.948 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.72, 24.05 APE9-dihe-in -92.66, 135.69 APE8-dihe-in -57.1, 135.94 APE8-rot-na 330.01 APE67-dihe-in -67.74, -17.88 -57.22, -36.2 APE12-dist-na 12.963 APE11-dist-na 8.955 APE10-dist-na 7.341 APE9-dist-in 5.668 None None None XRAY 2.75 0.217 0.277 B 314 274 31 0 0 10 [[724, 1007]] 1.0 7du8 Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
RET_HUMAN 7JU6B P07949 705 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.853 14.558 BLAminus -133.87, -179.77 59.88, 75.8 -96.18, 17.81 292.2, 77.2 -56.92, -30.18 in-in in 7.676 Saltbr-in 2.717 HRD-in -72.4, -43.27 78.98, -30.91 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.34, 21.56 APE9-dihe-in -92.4, 131.54 APE8-dihe-in -51.97, 128.7 APE8-rot-na 329.4 APE67-dihe-in -67.8, -13.47 -45.61, -41.79 APE12-dist-na 13.246 APE11-dist-na 9.219 APE10-dist-na 7.607 APE9-dist-in 5.405 None None None XRAY 2.06 0.199 0.249 B 314 286 22 0 0 9 [[724, 1007]] 1.0 7ju6 Homo sapiens TYR_RET_HUMAN TYR 4.1e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret

TYR_RET (Proto-oncogene tyrosine-protein kinase receptor Ret)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name