CAMK_PLK1 (Serine/threonine-protein kinase PLK1)

Total number of chains: 30
Active chains: 2
Uniprot: PLK1_HUMAN
Kinase Domain Residues: 53 - 305
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 30 100.0% AF-P53350-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P53350-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 45 - 313 0 None None Serine/threonine-protein kinase PLK1
AF-P53350-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 45 - 313 0 None None Serine/threonine-protein kinase PLK1
8X72A 2.2 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiio APEdist_ioio ANP ATPlike 37 - 330 0 None None Serine/threonine-protein kinase PLK1
2OU7A 2.4 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiio APEdist_ioio ANP ATPlike 37 - 328 0 None T210V Serine/threonine-protein kinase PLK1
2V5QA 2.3 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiio APEdist_ioio No_ligand No_ligand 39 - 323 0 None None Serine/threonine-protein kinase PLK1
2V5QB 2.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiio APEdist_ioio No_ligand No_ligand 39 - 323 0 None None Serine/threonine-protein kinase PLK1
2YACA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_ioio 937 Type1 39 - 329 0 None None Serine/threonine-protein kinase PLK1
3KB7A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_iooo 071 Type1 39 - 328 0 None None Serine/threonine-protein kinase PLK1
4A4LA 2.35 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_ioio 939 Type1 39 - 329 0 None None Serine/threonine-protein kinase PLK1
4A4OA 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio 664 Type1 39 - 329 0 None None Serine/threonine-protein kinase PLK1
9R8BA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio A1JCP Type1 37 - 326 0 None None Serine/threonine-protein kinase PLK1
9R8BB 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_iiio A1JCP Type1 37 - 323 0 None None Serine/threonine-protein kinase PLK1
9R8CA 2.243 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio R78 Type1 38 - 326 0 None None Serine/threonine-protein kinase PLK1
9R8CB 2.243 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio R78 Type1 38 - 323 0 None None Serine/threonine-protein kinase PLK1
4J52A 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio 1J3 Type1 38 - 330 0 None T210V Serine/threonine-protein kinase PLK1
4J53A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio 1J4 Type1 38 - 330 0 None T210V Serine/threonine-protein kinase PLK1
2RKUA 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio R78 Type1 37 - 330 0 None T210V Serine/threonine-protein kinase PLK1
8BJTA 2.188 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_iooo 8X7 Type1 39 - 330 0 None None Serine/threonine-protein kinase PLK1
3THBA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_ioio 3TA Type1 42 - 328 0 None T210V Serine/threonine-protein kinase PLK1
2OWBA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio 626 Type1 37 - 330 0 None T210V Serine/threonine-protein kinase PLK1
3FC2A 2.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio IBI Type1 37 - 329 0 None T210V Serine/threonine-protein kinase PLK1
9D0PA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio 8X7 Type1 37 - 330 0 None T210V Serine/threonine-protein kinase PLK1
9R1WAAA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio A1JCP Type1 38 - 334 0 None K225D,K226A Serine/threonine-protein kinase PLK1
9R1WBBB 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio A1JCP Type1 38 - 325 0 None K225D,K226A Serine/threonine-protein kinase PLK1
9R1XA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio R78 Type1 39 - 334 0 None K225D,K226A Serine/threonine-protein kinase PLK1
9R1XB 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio R78 Type1 39 - 326 0 None K225D,K226A Serine/threonine-protein kinase PLK1
9R1YAAA 2.602 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio A1JCQ Type1 38 - 334 0 None K225D,K226A Serine/threonine-protein kinase PLK1
9R1YBBB 2.602 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio A1JCQ Type1 38 - 325 0 None K225D,K226A Serine/threonine-protein kinase PLK1
5TA6A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_ioio 79D Type1 37 - 330 0 None None Serine/threonine-protein kinase PLK1
5TA8A 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_ioio 79C Type1 37 - 330 0 None None Serine/threonine-protein kinase PLK1

CAMK_PLK1 (Serine/threonine-protein kinase PLK1)

Total number of chains: 42
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 41 97.6% AF-P53350-K1A
DFGin ABAminus 1 2.4% 4J7BD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
Q6DRK7_DANRE 4J7BD 2.3 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 20 - 311 0 None D162N,E192F Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3D5WA 2.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 24 - 310 0 TPO196 None Serine/threonine-protein kinase PLK Danio rerio
Q6DRK7_DANRE 3D5UA 2.8 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiio APEdist_ioio No_ligand No_ligand 23 - 310 0 None None Serine/threonine-protein kinase PLK Danio rerio
Q6DRK7_DANRE 4J7BA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_nnio No_ligand No_ligand 18 - 311 0 None D162N,E192F Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3D5XA 2.8 Inactive DFGin‑BLAminus out-out in-none nonTYR APEdihe_aannn APEdist_innn KWT Type1 24 - 309 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DBEA 3.32 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aannn APEdist_ionn 4FR Type1 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DBFA 3.2 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn 5FR Type1 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DB8A 3.15 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn 1FR Type1 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DBCA 3.35 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn 2FR Type1 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DBDA 3.05 Inactive DFGin‑BLAminus out-out in-none nonTYR APEdihe_aannn APEdist_nnnn 3FR Type1 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DB6A 2.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiio APEdist_ioio FRS Type1.5_Front 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q6DRK7_DANRE 3D5VA 2.4 None DFGin‑BLAminus out-in in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 25 - 312 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
PLK1_HUMAN AF-P53350-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 45 - 313 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN AF-P53350-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 45 - 313 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 8X72A 2.2 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiio APEdist_ioio ANP ATPlike 37 - 330 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 2OU7A 2.4 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiio APEdist_ioio ANP ATPlike 37 - 328 0 None T210V Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 2V5QA 2.3 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiio APEdist_ioio No_ligand No_ligand 39 - 323 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 2V5QB 2.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiio APEdist_ioio No_ligand No_ligand 39 - 323 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 2YACA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_ioio 937 Type1 39 - 329 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 3KB7A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_iooo 071 Type1 39 - 328 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 4A4LA 2.35 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_ioio 939 Type1 39 - 329 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 4A4OA 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio 664 Type1 39 - 329 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 9R8BA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio A1JCP Type1 37 - 326 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 9R8BB 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_iiio A1JCP Type1 37 - 323 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 9R8CA 2.243 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio R78 Type1 38 - 326 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 9R8CB 2.243 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio R78 Type1 38 - 323 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 4J52A 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio 1J3 Type1 38 - 330 0 None T210V Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 4J53A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio 1J4 Type1 38 - 330 0 None T210V Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 2RKUA 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio R78 Type1 37 - 330 0 None T210V Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 8BJTA 2.188 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_iooo 8X7 Type1 39 - 330 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 3THBA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_ioio 3TA Type1 42 - 328 0 None T210V Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 2OWBA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio 626 Type1 37 - 330 0 None T210V Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 3FC2A 2.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio IBI Type1 37 - 329 0 None T210V Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 9D0PA 2.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio 8X7 Type1 37 - 330 0 None T210V Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 9R1WAAA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio A1JCP Type1 38 - 334 0 None K225D,K226A Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 9R1WBBB 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio A1JCP Type1 38 - 325 0 None K225D,K226A Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 9R1XA 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio R78 Type1 39 - 334 0 None K225D,K226A Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 9R1XB 2.84 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio R78 Type1 39 - 326 0 None K225D,K226A Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 9R1YAAA 2.602 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio A1JCQ Type1 38 - 334 0 None K225D,K226A Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 9R1YBBB 2.602 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_ioio A1JCQ Type1 38 - 325 0 None K225D,K226A Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 5TA6A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_ioio 79D Type1 37 - 330 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
PLK1_HUMAN 5TA8A 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_ioio 79C Type1 37 - 330 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens

CAMK_PLK1 (Serine/threonine-protein kinase PLK1)

Total number of chains: 12
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 91.7% 3D5UA
DFGin ABAminus 1 8.3% 4J7BD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
Q6DRK7_DANRE 4J7BD 2.3 Inactive DFGin‑ABAminus out-in in-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 20 - 311 0 None D162N,E192F Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3D5WA 2.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ADP ATPlike 24 - 310 0 TPO196 None Serine/threonine-protein kinase PLK Danio rerio
Q6DRK7_DANRE 3D5UA 2.8 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiio APEdist_ioio No_ligand No_ligand 23 - 310 0 None None Serine/threonine-protein kinase PLK Danio rerio
Q6DRK7_DANRE 4J7BA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_nnio No_ligand No_ligand 18 - 311 0 None D162N,E192F Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3D5XA 2.8 Inactive DFGin‑BLAminus out-out in-none nonTYR APEdihe_aannn APEdist_innn KWT Type1 24 - 309 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DBEA 3.32 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aannn APEdist_ionn 4FR Type1 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DBFA 3.2 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn 5FR Type1 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DB8A 3.15 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn 1FR Type1 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DBCA 3.35 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn 2FR Type1 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DBDA 3.05 Inactive DFGin‑BLAminus out-out in-none nonTYR APEdihe_aannn APEdist_nnnn 3FR Type1 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q4KMI8_DANRE 3DB6A 2.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiio APEdist_ioio FRS Type1.5_Front 24 - 310 0 None T196D Serine/threonine-protein kinase PLK Danio rerio
Q6DRK7_DANRE 3D5VA 2.4 None DFGin‑BLAminus out-in in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 25 - 312 0 None T196D Serine/threonine-protein kinase PLK Danio rerio