Ligand

Protein kinases in complex with 8X7 (Adavosertib)

Total number of genes: 4

Total number of chains: 4

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	4	5VD0A

Database table as tsv

Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type
CAMK	PLK1	PLK1_HUMAN	Serine/threonine-protein kinase PLK1	8BJTA	2.188	Inactive	DFGin	BLAminus	in-in	in-out	8X7	Type1
OTHER	PKMYT1	PMYT1_HUMAN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	5VD0A	2.13	Active	DFGin	BLAminus	in-in	in-in	8X7	Type1
OTHER	WEE1	WEE1_HUMAN	Wee1-like protein kinase	5V5YA	1.9	Active	DFGin	BLAminus	in-in	in-in	8X7	Type1
OTHER	WEE2	WEE2_HUMAN	Wee1-like protein kinase 2	5VDKA	2.7	Active	DFGin	BLAminus	in-in	in-in	8X7	Type1

Protein kinases in complex with 8X7

Total number of genes: 4

Total number of chains: 4

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	4	5VD0A

Database table as tsv

Organism	Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type
Homo sapiens	CAMK	PLK1	PLK1_HUMAN	Serine/threonine-protein kinase PLK1	8BJTA	2.188	Inactive	DFGin	BLAminus	in-in	in-out	8X7	Type1
Homo sapiens	OTHER	PKMYT1	PMYT1_HUMAN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	5VD0A	2.13	Active	DFGin	BLAminus	in-in	in-in	8X7	Type1
Homo sapiens	OTHER	WEE1	WEE1_HUMAN	Wee1-like protein kinase	5V5YA	1.9	Active	DFGin	BLAminus	in-in	in-in	8X7	Type1
Homo sapiens	OTHER	WEE2	WEE2_HUMAN	Wee1-like protein kinase 2	5VDKA	2.7	Active	DFGin	BLAminus	in-in	in-in	8X7	Type1

Protein kinases in complex with 8X7

Total number of genes: 0

Total number of chains: 0

Spatial	Dihedral	Chains	Representative

Database table as tsv

Organism	Group	Gene	UniprotID	Protein	PDB	Resolu	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type