CAMK_PLK1 (Serine/threonine-protein kinase PLK1)

Total number of chains: 30
Active chains: 2
Family: CAMK
Uniprot: PLK1_HUMAN
Kinase Domain Residues: 53 - 305
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 30 100.0% AF-P53350-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P53350-K1A 45 313 603.0 No_ligand No_ligand Active DFGin 5.55 14.018 BLAminus -138.81, -176.13 59.79, 75.65 -83.94, 15.34 292.62, 90.11 -62.81, -20.58 in-in in 9.039 Saltbr-in 2.576 HRD-in -77.19, -43.8 61.96, 8.95 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 167.37 APE9-dihe-na 111.84, 169.16 APE8-dihe-in -85.0, 135.3 APE8-rot-in 298.31 APE67-dihe-in -79.3, -5.41 -49.93, -42.14 APE12-dist-in 8.648 APE11-dist-in 11.487 APE10-dist-in 5.793 APE9-dist-in 3.502 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[53, 305]] 1.0 AF-P53350-K1 CAMK_PLK1_HUMAN CAMK 1.5e-79 272.9 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
AF-P53350-K3A 45 313 603.0 No_ligand No_ligand Active DFGin 5.342 13.979 BLAminus -140.81, -172.37 56.25, 72.33 -75.86, 12.77 292.93, 94.61 -62.92, -13.77 in-in in 9.329 Saltbr-in 2.577 HRD-in -78.81, -41.77 63.16, 8.34 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.05, 166.42 APE9-dihe-na 111.25, 170.64 APE8-dihe-in -84.99, 137.05 APE8-rot-in 295.25 APE67-dihe-in -75.5, -4.86 -51.24, -44.46 APE12-dist-in 8.632 APE11-dist-in 11.552 APE10-dist-in 5.872 APE9-dist-in 3.323 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[53, 305]] 1.0 AF-P53350-K3 CAMK_PLK1_HUMAN CAMK 1.5e-79 272.9 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
8X72A 37 330 603.0 ANP:401 ATPlike Inactive DFGin 5.674 14.562 BLAminus -124.66, -175.79 56.01, 84.34 -93.5, 28.11 290.48, 83.55 -67.08, -22.62 out-in out 10.036 Saltbr-in 3.369 HRD-in -69.02, -52.36 73.21, 2.03 in-in-out SNCiio in-out ActLoopNT-in 2.995 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -79.36, 95.87 APE9-dihe-na 140.51, 168.33 APE8-dihe-in -120.38, 96.0 APE8-rot-in 313.63 APE67-dihe-out -71.46, -55.88 -64.61, 149.56 APE12-dist-in 10.85 APE11-dist-out 7.455 APE10-dist-in 7.653 APE9-dist-out 8.043 None None None XRAY 2.2 0.198 0.25 A 333 294 0 0 0 0 [[53, 305]] 1.0 8x72 CAMK_PLK1_HUMAN CAMK 1.7e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
2OU7A 37 328 603.0 ANP:500 ATPlike Inactive DFGin 5.511 14.626 BLAminus -126.46, 177.9 64.03, 83.89 -94.43, 31.27 293.9, 81.92 -69.65, -29.63 out-in out 10.018 Saltbr-in 3.599 HRD-in -73.43, -50.53 79.22, -6.25 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -86.17, 94.2 APE9-dihe-na 146.34, 174.25 APE8-dihe-in -131.14, 97.57 APE8-rot-in 299.54 APE67-dihe-out -68.04, -58.6 -56.03, 146.92 APE12-dist-in 10.381 APE11-dist-out 7.186 APE10-dist-in 7.436 APE9-dist-out 8.241 T210V None None XRAY 2.4 0.205 0.235 A 335 292 0 0 0 0 [[53, 305]] 1.0 2ou7 CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
2V5QA 39 323 603.0 No_ligand No_ligand Inactive DFGin 5.686 14.718 BLAminus -129.1, -167.08 62.93, 75.17 -93.89, 21.76 291.51, 90.84 -61.9, -28.72 out-in out 10.023 Saltbr-in 3.055 HRD-in -67.98, -52.02 73.91, 7.34 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -88.56, 3.75 APE9-dihe-na -179.48, -164.77 APE8-dihe-in -107.94, 115.2 APE8-rot-in 298.84 APE67-dihe-out -71.25, -55.87 -61.61, 160.98 APE12-dist-in 10.438 APE11-dist-out 6.237 APE10-dist-in 5.122 APE9-dist-out 8.333 None None None XRAY 2.3 0.184 0.224 A 315 285 0 0 0 0 [[53, 305]] 1.0 2v5q CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
2V5QB 39 323 603.0 No_ligand No_ligand Inactive DFGin 5.685 14.925 BLAminus -131.35, -166.96 60.96, 77.54 -92.83, 32.21 286.27, 87.97 -68.24, -26.27 in-out in 9.999 Saltbr-out 3.841 HRD-in -74.56, -53.71 79.97, 1.03 out-in-out SNCoio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -91.44, 9.2 APE9-dihe-na -170.42, 178.21 APE8-dihe-in -101.74, 116.95 APE8-rot-in 316.2 APE67-dihe-out -61.71, -54.24 -52.66, 144.9 APE12-dist-in 9.991 APE11-dist-out 6.774 APE10-dist-in 6.407 APE9-dist-out 8.407 None None None XRAY 2.3 0.184 0.224 B 315 285 0 0 0 0 [[53, 305]] 1.0 2v5q CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
2YACA 39 329 603.0 937:501 Type1 Inactive DFGin 5.716 14.305 BLAminus -136.25, -176.52 54.6, 87.71 -92.92, 28.24 289.9, 84.23 -75.6, -9.88 in-in in 9.414 Saltbr-in 2.832 HRD-in -79.87, -54.28 83.91, -4.3 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_ioio APE10-dihe-na -90.18, 95.11 APE9-dihe-na 155.4, 174.07 APE8-dihe-in -130.99, 84.18 APE8-rot-out 67.16 APE67-dihe-out -74.05, -70.88 -62.65, 161.23 APE12-dist-in 11.068 APE11-dist-out 7.321 APE10-dist-in 7.625 APE9-dist-out 8.136 None None None XRAY 2.2 0.213 0.255 A 311 291 0 0 0 0 [[53, 305]] 1.0 2yac CAMK_PLK1_HUMAN CAMK 2.5e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
3KB7A 39 328 603.0 071:1 Type1 Inactive DFGin 5.709 14.042 BLAminus -133.88, 179.17 62.15, 88.77 -94.79, 24.7 288.92, 88.27 -73.01, -6.62 in-in in 8.887 Saltbr-in 2.674 HRD-in -67.89, -55.24 69.06, -3.76 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iooo APE10-dihe-na -99.22, 86.88 APE9-dihe-na 165.83, 172.24 APE8-dihe-in -120.96, 91.28 APE8-rot-out 68.09 APE67-dihe-out -76.36, -59.91 -62.3, 158.23 APE12-dist-in 11.13 APE11-dist-out 7.377 APE10-dist-out 8.077 APE9-dist-out 8.17 None None NMM324 XRAY 2.5 0.212 0.303 A 311 290 0 0 0 0 [[53, 305]] 1.0 3kb7 CAMK_PLK1_HUMAN CAMK 2.5e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
4A4LA 39 329 603.0 939:1331 Type1 Inactive DFGin 5.78 14.135 BLAminus -141.7, -176.08 58.67, 82.87 -91.4, 34.14 289.94, 83.08 -71.42, -15.93 in-in in 9.42 Saltbr-in 2.94 HRD-in -74.58, -53.49 81.34, -4.51 in-in-out SNCiio in-out ActLoopNT-in 2.917 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_ioio APE10-dihe-na -83.54, 86.55 APE9-dihe-na 154.14, -178.12 APE8-dihe-in -129.31, 90.58 APE8-rot-out 60.31 APE67-dihe-out -60.53, -82.61 -62.07, 154.01 APE12-dist-in 11.059 APE11-dist-out 7.324 APE10-dist-in 7.616 APE9-dist-out 8.427 None None None XRAY 2.35 0.224 0.274 A 311 291 0 0 0 0 [[53, 305]] 1.0 4a4l CAMK_PLK1_HUMAN CAMK 2.5e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
4A4OA 39 329 603.0 664:1332 Type1 Inactive DFGin 5.643 14.005 BLAminus -140.91, 173.61 55.04, 90.94 -98.45, 26.61 287.86, 85.19 -77.07, -1.22 in-in in 9.339 Saltbr-in 3.348 HRD-in -69.08, -52.1 82.91, 0.02 in-in-out SNCiio in-out ActLoopNT-in 3.005 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -84.2, 81.23 APE9-dihe-na 164.33, -176.93 APE8-dihe-in -120.87, 80.43 APE8-rot-in 310.59 APE67-dihe-out -59.02, -78.88 -57.5, 148.27 APE12-dist-in 11.161 APE11-dist-out 7.22 APE10-dist-in 7.762 APE9-dist-out 8.205 None None None XRAY 2.7 0.23 0.282 A 311 291 0 0 0 0 [[53, 305]] 1.0 4a4o CAMK_PLK1_HUMAN CAMK 2.5e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
9R8BA 37 326 603.0 A1JCP:1001 Type1 Inactive DFGin 5.764 14.419 BLAminus -135.37, -173.77 58.86, 75.37 -91.12, 20.8 284.65, 94.62 -63.52, -25.59 in-in in 8.49 Saltbr-in 2.716 HRD-in -71.84, -53.97 76.03, -0.52 in-in-out SNCiio in-out ActLoopNT-in 3.015 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -85.35, 5.7 APE9-dihe-na -171.65, -172.53 APE8-dihe-in -108.35, 119.77 APE8-rot-in 298.21 APE67-dihe-out -65.23, -55.38 -66.82, 157.06 APE12-dist-in 10.619 APE11-dist-out 6.937 APE10-dist-in 5.948 APE9-dist-out 8.318 None None None XRAY 2.2 0.191 0.238 A 315 290 0 0 0 0 [[53, 305]] 1.0 9r8b CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
9R8BB 37 323 603.0 A1JCP:402 Type1 Inactive DFGin 5.835 14.292 BLAminus -131.75, -174.5 64.87, 76.68 -96.77, 19.5 288.39, 99.04 -77.27, -4.94 in-in in 8.12 Saltbr-in 2.754 HRD-out -68.92, 136.67 -118.63, -11.46 in-in-out SNCiio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na 86.04, 0.68 APE9-dihe-na 169.71, -156.66 APE8-dihe-in -118.48, 123.54 APE8-rot-in 319.34 APE67-dihe-out -62.56, -51.97 -66.18, 154.73 APE12-dist-in 10.472 APE11-dist-in 8.19 APE10-dist-in 5.74 APE9-dist-out 9.562 None None None XRAY 2.2 0.191 0.238 B 315 287 0 0 0 0 [[53, 305]] 1.0 9r8b CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
9R8CA 38 326 603.0 R78:1001 Type1 Inactive DFGin 5.585 14.99 BLAminus -126.1, -176.63 65.4, 78.62 -95.8, 30.2 285.88, 88.19 -70.16, -23.86 in-in in 9.097 Saltbr-in 2.871 HRD-in -73.52, -53.38 78.38, -0.66 in-in-out SNCiio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -86.03, 32.02 APE9-dihe-na 163.26, -177.26 APE8-dihe-in -109.84, 116.09 APE8-rot-in 291.16 APE67-dihe-out -62.02, -59.2 -61.3, 153.09 APE12-dist-in 10.411 APE11-dist-out 6.256 APE10-dist-in 5.762 APE9-dist-out 8.623 None None None XRAY 2.243 0.191 0.236 A 315 289 0 0 0 0 [[53, 305]] 1.0 9r8c CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
9R8CB 38 323 603.0 R78:1001 Type1 Inactive DFGin 5.546 14.996 BLAminus -130.55, -176.06 59.62, 83.99 -94.79, 30.62 285.83, 86.69 -68.45, -26.03 in-in in 9.151 Saltbr-in 2.768 HRD-in -75.84, -53.52 77.99, 2.7 in-in-out SNCiio in-out ActLoopNT-in 2.953 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -89.08, 50.7 APE9-dihe-na 152.38, 176.7 APE8-dihe-in -113.61, 115.98 APE8-rot-in 316.69 APE67-dihe-out -67.47, -56.35 -62.32, 152.06 APE12-dist-in 9.96 APE11-dist-out 7.059 APE10-dist-in 6.623 APE9-dist-out 8.508 None None None XRAY 2.243 0.191 0.236 B 315 286 0 0 0 0 [[53, 305]] 1.0 9r8c CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
4J52A 38 330 603.0 1J3:400 Type1 Inactive DFGin 5.673 14.405 BLAminus -132.19, -178.32 57.1, 88.41 -99.88, 23.54 290.9, 84.86 -66.29, -8.43 in-in in 9.392 Saltbr-in 2.701 HRD-in -83.32, -51.41 78.14, -8.7 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -92.24, 97.88 APE9-dihe-na 154.03, 172.56 APE8-dihe-in -123.15, 84.89 APE8-rot-in 302.52 APE67-dihe-out -69.1, -50.77 -69.03, 151.29 APE12-dist-in 10.979 APE11-dist-out 7.354 APE10-dist-in 7.818 APE9-dist-out 7.821 T210V None None XRAY 2.3 0.198 0.241 A 293 293 0 0 0 0 [[53, 305]] 1.0 4j52 CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
4J53A 38 330 603.0 1J4:403 Type1 Inactive DFGin 5.64 14.579 BLAminus -129.35, -169.37 44.41, 85.29 -91.22, 24.89 291.84, 82.06 -64.71, -23.25 in-in in 9.981 Saltbr-in 3.01 HRD-in -75.81, -49.76 74.88, 0.23 in-in-out SNCiio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -78.39, 101.76 APE9-dihe-na 146.02, 166.78 APE8-dihe-in -121.83, 82.96 APE8-rot-in 302.16 APE67-dihe-out -75.51, -62.04 -60.01, 151.77 APE12-dist-in 10.953 APE11-dist-out 7.401 APE10-dist-in 7.763 APE9-dist-out 7.856 T210V None None XRAY 2.5 0.183 0.24 A 293 293 0 0 0 0 [[53, 305]] 1.0 4j53 CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
2RKUA 37 330 603.0 R78:500 Type1 Inactive DFGin 5.678 15.017 BLAminus -134.22, -169.5 54.06, 79.11 -86.67, 25.63 283.82, 88.21 -64.51, -26.07 in-in in 9.717 Saltbr-in 3.08 HRD-in -74.95, -48.26 75.93, -2.57 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -90.21, 90.69 APE9-dihe-na 162.46, 178.28 APE8-dihe-in -124.7, 88.6 APE8-rot-in 309.54 APE67-dihe-out -73.41, -64.04 -71.02, 160.05 APE12-dist-in 10.929 APE11-dist-out 7.283 APE10-dist-in 7.921 APE9-dist-out 8.134 T210V None None XRAY 1.95 0.192 0.241 A 294 294 0 0 0 0 [[53, 305]] 1.0 2rku CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
8BJTA 39 330 603.0 8X7:402 Type1 Inactive DFGin 5.743 14.312 BLAminus -146.49, -170.45 55.69, 70.04 -90.08, 22.34 281.62, 90.95 -60.02, -37.94 in-in in 9.222 Saltbr-in 2.728 HRD-in -68.54, -47.7 72.42, -10.0 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iooo APE10-dihe-na -90.89, 99.31 APE9-dihe-na 143.06, 169.47 APE8-dihe-in -120.75, 101.21 APE8-rot-out 199.98 APE67-dihe-out -76.79, -55.69 -65.4, 158.12 APE12-dist-in 11.16 APE11-dist-out 7.403 APE10-dist-out 8.236 APE9-dist-out 8.563 None None None XRAY 2.188 0.203 0.255 A 294 292 0 0 0 0 [[53, 305]] 1.0 8bjt CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
3THBA 42 328 603.0 3TA:1 Type1 Inactive DFGin 5.763 14.246 BLAminus -135.92, -170.43 55.15, 75.45 -87.11, 14.2 290.23, 88.06 -65.07, -8.71 in-in in 9.125 Saltbr-in 3.549 HRD-in -66.85, -49.24 73.84, -10.07 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_ioio APE10-dihe-na -91.42, 101.79 APE9-dihe-na 126.02, 172.43 APE8-dihe-in -121.57, 103.22 APE8-rot-out 68.36 APE67-dihe-out -75.15, -60.09 -61.3, 157.38 APE12-dist-in 11.579 APE11-dist-out 7.552 APE10-dist-in 7.746 APE9-dist-out 8.65 T210V None None XRAY 2.5 0.253 0.286 A 333 287 0 0 0 0 [[53, 305]] 1.0 3thb CAMK_PLK1_HUMAN CAMK 1.7e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
2OWBA 37 330 603.0 626:500 Type1 Inactive DFGin 5.741 14.273 BLAminus -131.62, -172.7 55.05, 82.45 -94.97, 27.99 289.46, 84.52 -70.38, -17.86 in-in in 9.505 Saltbr-in 2.635 HRD-in -72.25, -49.78 72.96, -0.12 in-in-out SNCiio in-out ActLoopNT-in 3.006 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -85.58, 102.01 APE9-dihe-na 139.92, 169.2 APE8-dihe-in -127.98, 85.88 APE8-rot-in 302.45 APE67-dihe-out -70.16, -61.75 -57.83, 150.59 APE12-dist-in 10.943 APE11-dist-out 7.422 APE10-dist-in 7.619 APE9-dist-out 7.979 T210V None None XRAY 2.1 0.205 0.243 A 335 294 0 0 0 0 [[53, 305]] 1.0 2owb CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
3FC2A 37 329 603.0 IBI:10 Type1 Inactive DFGin 5.687 14.844 BLAminus -136.2, -169.15 47.8, 83.29 -92.73, 30.51 290.96, 88.11 -72.2, -20.77 in-in in 9.845 Saltbr-in 2.787 HRD-in -72.68, -50.74 75.03, 6.56 in-in-out SNCiio in-out ActLoopNT-in 2.972 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -91.8, 110.95 APE9-dihe-na 128.06, 168.28 APE8-dihe-in -129.49, 88.48 APE8-rot-in 292.3 APE67-dihe-out -76.49, -62.11 -61.16, 163.08 APE12-dist-in 11.004 APE11-dist-out 7.364 APE10-dist-in 7.532 APE9-dist-out 7.885 T210V None None XRAY 2.45 0.184 0.226 A 335 293 0 0 0 0 [[53, 305]] 1.0 3fc2 CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
9D0PA 37 330 603.0 8X7:401 Type1 Inactive DFGin 5.932 14.467 BLAminus -127.97, -167.66 73.35, 57.17 -81.61, 36.59 285.64, 88.68 -94.22, -12.32 in-in in 9.093 Saltbr-in 2.758 HRD-in -81.82, -53.71 82.64, -7.07 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -92.87, 112.89 APE9-dihe-na 127.84, 173.17 APE8-dihe-in -124.26, 98.89 APE8-rot-in 301.22 APE67-dihe-out -72.74, -55.92 -71.3, 155.26 APE12-dist-in 11.296 APE11-dist-out 7.351 APE10-dist-in 7.483 APE9-dist-out 8.252 T210V None None XRAY 2.65 0.247 0.29 A 335 294 0 0 0 0 [[53, 305]] 1.0 9d0p CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
9R1WAAA 38 334 603.0 A1JCP:401 Type1 Inactive DFGin 5.629 14.307 BLAminus -134.11, -168.09 56.45, 78.1 -90.07, 23.96 287.47, 94.05 -61.0, -27.64 in-in in 9.056 Saltbr-in 2.817 HRD-in -73.41, -49.99 71.11, 3.55 in-in-out SNCiio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -89.16, 9.34 APE9-dihe-na -169.47, 176.32 APE8-dihe-in -98.59, 112.0 APE8-rot-in 302.37 APE67-dihe-out -62.18, -51.19 -58.71, 150.32 APE12-dist-in 10.183 APE11-dist-out 6.559 APE10-dist-in 6.236 APE9-dist-out 8.502 K225D,K226A None None XRAY 2.2 0.18 0.216 AAA 325 297 0 0 0 0 [[53, 305]] 1.0 9r1w CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
9R1WBBB 38 325 603.0 A1JCP:401 Type1 Inactive DFGin 5.63 14.351 BLAminus -133.86, -166.71 56.12, 78.59 -90.53, 23.21 288.19, 92.88 -61.02, -27.23 in-in in 9.229 Saltbr-in 2.745 HRD-in -73.38, -50.78 71.42, 4.57 in-in-out SNCiio in-out ActLoopNT-in 2.97 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -89.57, 8.7 APE9-dihe-na -168.16, 173.41 APE8-dihe-in -98.08, 111.85 APE8-rot-in 305.79 APE67-dihe-out -62.5, -50.96 -59.11, 151.11 APE12-dist-in 10.072 APE11-dist-out 6.598 APE10-dist-in 6.18 APE9-dist-out 8.439 K225D,K226A None None XRAY 2.2 0.18 0.216 BBB 325 288 0 0 0 0 [[53, 305]] 1.0 9r1w CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
9R1XA 39 334 603.0 R78:401 Type1 Inactive DFGin 5.451 14.746 BLAminus -129.34, -169.27 61.33, 81.84 -99.46, 30.78 291.65, 94.79 -60.61, -43.02 in-in in 9.685 Saltbr-in 2.721 HRD-in -71.39, -48.31 73.02, 3.83 in-in-out SNCiio in-out ActLoopNT-in 2.971 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -86.63, 46.88 APE9-dihe-na 161.22, 163.69 APE8-dihe-in -103.28, 108.1 APE8-rot-in 301.35 APE67-dihe-out -58.97, -56.16 -54.1, 148.74 APE12-dist-in 10.388 APE11-dist-out 6.56 APE10-dist-in 6.741 APE9-dist-out 8.509 K225D,K226A None None XRAY 2.84 0.222 0.277 A 325 296 0 0 0 0 [[53, 305]] 1.0 9r1x CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
9R1XB 39 326 603.0 R78:401 Type1 Inactive DFGin 5.445 14.726 BLAminus -129.89, -169.09 62.76, 81.42 -99.44, 28.81 292.45, 94.66 -58.03, -43.63 in-in in 9.666 Saltbr-in 2.714 HRD-in -71.6, -47.96 72.32, 5.61 in-in-out SNCiio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -82.43, 34.44 APE9-dihe-na 160.48, 165.73 APE8-dihe-in -102.91, 108.17 APE8-rot-in 301.26 APE67-dihe-out -58.46, -55.69 -54.97, 148.64 APE12-dist-in 10.404 APE11-dist-out 6.532 APE10-dist-in 5.999 APE9-dist-out 8.447 K225D,K226A None None XRAY 2.84 0.222 0.277 B 325 288 0 0 0 0 [[53, 305]] 1.0 9r1x CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
9R1YAAA 38 334 603.0 A1JCQ:401 Type1 Inactive DFGin 5.493 14.267 BLAminus -126.75, -172.44 65.19, 77.92 -95.78, 35.59 294.04, 83.7 -66.64, -28.98 in-in in 9.464 Saltbr-in 2.744 HRD-in -71.96, -50.24 71.88, 5.14 in-in-out SNCiio in-out ActLoopNT-in 3.103 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -88.57, 8.2 APE9-dihe-na -166.23, -178.27 APE8-dihe-in -105.79, 106.71 APE8-rot-in 300.95 APE67-dihe-out -66.32, -52.43 -54.05, 151.38 APE12-dist-in 10.28 APE11-dist-out 6.494 APE10-dist-in 6.137 APE9-dist-out 8.38 K225D,K226A None None XRAY 2.602 0.187 0.218 AAA 325 297 0 0 0 0 [[53, 305]] 1.0 9r1y CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
9R1YBBB 38 325 603.0 A1JCQ:401 Type1 Inactive DFGin 5.517 14.349 BLAminus -126.84, -171.95 66.19, 77.61 -96.17, 35.42 294.69, 83.98 -66.59, -29.54 in-in in 9.503 Saltbr-in 2.744 HRD-in -72.69, -50.41 71.98, 5.19 in-in-out SNCiio in-out ActLoopNT-in 3.11 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -88.39, 7.64 APE9-dihe-na -166.1, -178.49 APE8-dihe-in -105.58, 106.71 APE8-rot-in 302.14 APE67-dihe-out -65.99, -51.73 -54.43, 151.5 APE12-dist-in 10.301 APE11-dist-out 6.48 APE10-dist-in 5.991 APE9-dist-out 8.363 K225D,K226A None None XRAY 2.602 0.187 0.218 BBB 325 288 0 0 0 0 [[53, 305]] 1.0 9r1y CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
5TA6A 37 330 603.0 79D:1000 Type1 Inactive DFGin 5.768 14.691 BLAminus -129.81, 178.93 63.79, 86.6 -95.82, 28.6 292.13, 79.82 -68.79, -23.38 in-in in 9.776 Saltbr-in 3.06 HRD-in -68.63, -52.95 71.96, 8.35 in-in-out SNCiio in-out ActLoopNT-in 2.889 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_ioio APE10-dihe-na -85.92, 111.12 APE9-dihe-na 138.09, 164.23 APE8-dihe-in -126.56, 95.9 APE8-rot-out 85.27 APE67-dihe-out -71.06, -59.19 -57.19, 156.45 APE12-dist-in 10.908 APE11-dist-out 7.328 APE10-dist-in 7.694 APE9-dist-out 7.599 None None None XRAY 2.5 0.183 0.26 A 358 294 0 0 0 0 [[53, 305]] 1.0 5ta6 CAMK_PLK1_HUMAN CAMK 2.2e-78 269.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
5TA8A 37 330 603.0 79C:402 Type1 Inactive DFGin 5.598 14.311 BLAminus -141.08, -172.7 51.52, 90.37 -96.67, 41.3 290.69, 89.43 -72.33, -19.61 in-in in 9.107 Saltbr-in 2.727 HRD-in -66.37, -49.24 72.53, -11.97 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_ioio APE10-dihe-na -88.19, 81.36 APE9-dihe-na 134.61, 175.47 APE8-dihe-in -125.29, 109.1 APE8-rot-out 49.04 APE67-dihe-out -73.09, -62.08 -71.65, 169.34 APE12-dist-in 10.81 APE11-dist-out 7.473 APE10-dist-in 7.188 APE9-dist-out 8.693 None None None XRAY 2.6 0.185 0.247 A 358 294 0 0 0 0 [[53, 305]] 1.0 5ta8 CAMK_PLK1_HUMAN CAMK 2.2e-78 269.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1

CAMK_PLK1 (Serine/threonine-protein kinase PLK1)

Total number of chains: 42
Active chains: 2
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 41 97.6% AF-P53350-K1A
DFGin ABAminus 1 2.4% 4J7BD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
Q6DRK7_DANRE 4J7BD Q6DRK7 20 311 595.0 No_ligand No_ligand Inactive DFGin 5.487 14.555 ABAminus -129.81, -7.43 -133.83, 113.48 -107.04, 20.33 291.52, 92.27 -51.62, -38.38 out-in out 10.214 Saltbr-in 2.966 HRD-in -68.9, -50.24 76.71, 4.14 in-in-out SNCiio in-out ActLoopNT-in 2.745 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.82 APE8-dihe-in -131.87, 100.17 APE8-rot-in 301.55 APE67-dihe-out -78.82, -54.23 -64.35, 166.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.947 D162N,E192F None None XRAY 2.3 0.208 0.264 D 297 281 11 0 0 11 [[39, 291]] 1.0 4j7b Danio rerio CAMK_PLK1_DANRE CAMK 8.1e-76 260.6 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3D5WA Q4KMI8 24 310 595.0 ADP:313 ATPlike Inactive DFGin 5.84 15.103 BLAminus -136.31, -173.3 52.58, 90.43 -100.9, 29.72 290.61, 88.81 -67.31, -18.54 out-out out 10.538 Saltbr-out 4.57 HRD-in -72.81, -47.33 67.56, -5.93 out-in-in SNCoii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.0, 153.74 APE9-dihe-na 145.11, -167.91 APE8-dihe-in -110.25, 127.19 APE8-rot-in 299.86 APE67-dihe-in -70.02, -15.96 -37.98, -47.89 APE12-dist-in 8.251 APE11-dist-in 11.275 APE10-dist-in 5.646 APE9-dist-in 3.912 None TPO196 TPO196 XRAY 2.6 0.244 0.271 A 317 285 2 0 0 0 [[39, 291]] 1.0 3d5w Danio rerio CAMK_PLK1_DANRE CAMK 4.6e-77 264.7 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q6DRK7_DANRE 3D5UA Q6DRK7 23 310 595.0 No_ligand No_ligand Inactive DFGin 5.693 14.809 BLAminus -132.0, -170.66 53.21, 91.71 -105.63, 34.97 291.53, 90.32 -70.7, -17.69 out-out out 10.7 Saltbr-out 4.35 HRD-in -73.43, -47.86 66.94, -9.91 out-in-out SNCoio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -83.53, 77.69 APE9-dihe-na 160.43, 176.55 APE8-dihe-in -120.81, 90.57 APE8-rot-in 316.96 APE67-dihe-out -68.11, -72.46 -73.03, 158.49 APE12-dist-in 10.666 APE11-dist-out 7.401 APE10-dist-in 7.522 APE9-dist-out 8.466 None None None XRAY 2.8 0.231 0.281 A 317 288 0 0 0 0 [[39, 291]] 1.0 3d5u Danio rerio CAMK_PLK1_DANRE CAMK 4.6e-77 264.7 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q6DRK7_DANRE 4J7BA Q6DRK7 18 311 595.0 No_ligand No_ligand Inactive DFGin 5.957 14.822 BLAminus -127.79, -166.66 63.28, 73.86 -94.07, 24.02 287.22, 93.09 -58.39, -32.32 in-in in 9.948 Saltbr-in 2.526 HRD-in -69.09, -53.7 77.98, -8.47 in-in-out SNCiio in-out ActLoopNT-in 2.814 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnio APE10-dihe-na 999.0, 170.84 APE9-dihe-na -82.59, -164.35 APE8-dihe-in -106.73, 113.42 APE8-rot-out 172.88 APE67-dihe-out -56.23, -64.85 -68.6, 152.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.933 APE9-dist-out 8.473 D162N,E192F None None XRAY 2.3 0.208 0.264 A 297 284 10 0 0 10 [[39, 291]] 1.0 4j7b Danio rerio CAMK_PLK1_DANRE CAMK 8.1e-76 260.6 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3D5XA Q4KMI8 24 309 595.0 KWT:1 Type1 Inactive DFGin 5.748 14.936 BLAminus -139.39, -170.01 59.65, 84.09 -100.6, 25.02 290.64, 93.65 -64.4, -14.86 out-out out 10.666 Saltbr-out 4.394 HRD-in -69.94, -48.19 73.11, -11.18 out-in-none SNCoin in-none ActLoopNT-in 3.068 ActLoopCT-none nonTYR APEdihe_aannn APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-in 10.296 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 2.8 0.263 0.299 A 301 279 7 0 0 7 [[39, 291]] 1.0 3d5x Danio rerio CAMK_PLK1_DANRE CAMK 8.9e-77 263.8 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DBEA Q4KMI8 24 310 595.0 4FR:1 Type1 Inactive DFGin 5.33 14.261 BLAminus -130.08, -172.43 53.96, 104.63 -115.22, 13.87 295.84, 91.17 -49.61, -15.58 out-out out 10.073 Saltbr-out 4.367 HRD-in -75.7, -52.21 77.46, -22.23 out-in-out SNCoio in-out ActLoopNT-in 2.969 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ionn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -89.97, -74.84 999.0, 157.6 APE12-dist-in 10.405 APE11-dist-out 7.734 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 3.32 0.237 0.27 A 301 284 3 0 0 3 [[39, 291]] 1.0 3dbe Danio rerio CAMK_PLK1_DANRE CAMK 8.9e-77 263.8 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DBFA Q4KMI8 24 310 595.0 5FR:1 Type1 Inactive DFGin 5.569 14.507 BLAminus -126.48, -167.26 59.45, 92.34 -110.0, 25.26 297.55, 90.95 -54.7, -27.45 in-out in 9.878 Saltbr-out 4.027 HRD-in -77.45, -40.3 68.16, -16.48 out-in-none SNCoin in-none ActLoopNT-in 2.929 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 3.2 0.234 0.275 A 301 261 26 0 0 20 [[39, 291]] 1.0 3dbf Danio rerio CAMK_PLK1_DANRE CAMK 8.9e-77 263.8 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DB8A Q4KMI8 24 310 595.0 1FR:313 Type1 Inactive DFGin 5.759 14.657 BLAminus -132.17, -175.89 60.33, 81.89 -97.25, 28.2 286.75, 81.14 -57.5, -31.84 in-out in 9.909 Saltbr-out 3.829 HRD-in -71.72, -45.68 69.14, -18.96 out-in-none SNCoin in-none ActLoopNT-in 2.828 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 3.15 0.232 0.274 A 317 261 26 0 0 20 [[39, 291]] 1.0 3db8 Danio rerio CAMK_PLK1_DANRE CAMK 1.1e-76 263.5 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DBCA Q4KMI8 24 310 595.0 2FR:313 Type1 Inactive DFGin 5.734 14.664 BLAminus -136.39, -168.79 53.28, 74.51 -89.66, 27.23 289.49, 88.8 -63.71, -13.19 in-out in 9.639 Saltbr-out 4.056 HRD-in -85.71, -43.45 67.47, -24.22 out-in-none SNCoin in-none ActLoopNT-in 3.018 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 3.35 0.245 0.288 A 317 261 26 0 0 20 [[39, 291]] 1.0 3dbc Danio rerio CAMK_PLK1_DANRE CAMK 1.1e-76 263.5 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DBDA Q4KMI8 24 310 595.0 3FR:313 Type1 Inactive DFGin 5.909 14.941 BLAminus -134.29, -167.77 57.39, 80.83 -100.95, 31.61 290.61, 85.71 -63.54, -20.94 out-out out 10.044 Saltbr-out 4.299 HRD-in -65.46, -53.96 81.32, -10.52 out-in-none SNCoin in-none ActLoopNT-in 2.867 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 3.05 0.252 0.276 A 317 261 26 0 0 20 [[39, 291]] 1.0 3dbd Danio rerio CAMK_PLK1_DANRE CAMK 1.1e-76 263.5 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DB6A Q4KMI8 24 310 595.0 FRS:1 Type1.5_Front Inactive DFGin 5.817 15.954 BLAminus -142.4, -169.51 60.61, 84.89 -102.5, 26.5 287.92, 83.73 -63.45, -15.75 out-out out 11.643 Saltbr-out 7.205 HRD-in -75.01, -40.51 67.41, -16.08 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -91.76, 87.23 APE9-dihe-na 133.88, 161.1 APE8-dihe-in -107.95, 116.2 APE8-rot-in 306.39 APE67-dihe-out -75.67, -58.88 -71.76, 164.15 APE12-dist-in 11.272 APE11-dist-out 7.484 APE10-dist-in 7.511 APE9-dist-out 8.776 T196D None None XRAY 2.85 0.225 0.257 A 301 287 0 0 0 0 [[39, 291]] 1.0 3db6 Danio rerio CAMK_PLK1_DANRE CAMK 8.9e-77 263.8 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q6DRK7_DANRE 3D5VA Q6DRK7 25 312 595.0 No_ligand No_ligand None DFGin 5.892 14.868 BLAminus -136.77, -170.94 58.3, 78.56 -96.91, 24.94 292.69, 93.45 -65.35, -19.51 out-in out 10.405 Saltbr-in 3.408 HRD-in -70.1, -47.78 72.09, -9.5 in-in-none SNCiin in-none ActLoopNT-in 2.884 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 2.4 0.237 0.269 A 317 260 28 0 0 19 [[39, 291]] 1.0 3d5v Danio rerio CAMK_PLK1_DANRE CAMK 1.1e-76 263.5 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
PLK1_HUMAN AF-P53350-K1A P53350 45 313 603.0 No_ligand No_ligand Active DFGin 5.55 14.018 BLAminus -138.81, -176.13 59.79, 75.65 -83.94, 15.34 292.62, 90.11 -62.81, -20.58 in-in in 9.039 Saltbr-in 2.576 HRD-in -77.19, -43.8 61.96, 8.95 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 167.37 APE9-dihe-na 111.84, 169.16 APE8-dihe-in -85.0, 135.3 APE8-rot-in 298.31 APE67-dihe-in -79.3, -5.41 -49.93, -42.14 APE12-dist-in 8.648 APE11-dist-in 11.487 APE10-dist-in 5.793 APE9-dist-in 3.502 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[53, 305]] 1.0 AF-P53350-K1 Homo sapiens CAMK_PLK1_HUMAN CAMK 1.5e-79 272.9 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN AF-P53350-K3A P53350 45 313 603.0 No_ligand No_ligand Active DFGin 5.342 13.979 BLAminus -140.81, -172.37 56.25, 72.33 -75.86, 12.77 292.93, 94.61 -62.92, -13.77 in-in in 9.329 Saltbr-in 2.577 HRD-in -78.81, -41.77 63.16, 8.34 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.05, 166.42 APE9-dihe-na 111.25, 170.64 APE8-dihe-in -84.99, 137.05 APE8-rot-in 295.25 APE67-dihe-in -75.5, -4.86 -51.24, -44.46 APE12-dist-in 8.632 APE11-dist-in 11.552 APE10-dist-in 5.872 APE9-dist-in 3.323 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[53, 305]] 1.0 AF-P53350-K3 Homo sapiens CAMK_PLK1_HUMAN CAMK 1.5e-79 272.9 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 8X72A P53350 37 330 603.0 ANP:401 ATPlike Inactive DFGin 5.674 14.562 BLAminus -124.66, -175.79 56.01, 84.34 -93.5, 28.11 290.48, 83.55 -67.08, -22.62 out-in out 10.036 Saltbr-in 3.369 HRD-in -69.02, -52.36 73.21, 2.03 in-in-out SNCiio in-out ActLoopNT-in 2.995 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -79.36, 95.87 APE9-dihe-na 140.51, 168.33 APE8-dihe-in -120.38, 96.0 APE8-rot-in 313.63 APE67-dihe-out -71.46, -55.88 -64.61, 149.56 APE12-dist-in 10.85 APE11-dist-out 7.455 APE10-dist-in 7.653 APE9-dist-out 8.043 None None None XRAY 2.2 0.198 0.25 A 333 294 0 0 0 0 [[53, 305]] 1.0 8x72 Homo sapiens CAMK_PLK1_HUMAN CAMK 1.7e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 2OU7A P53350 37 328 603.0 ANP:500 ATPlike Inactive DFGin 5.511 14.626 BLAminus -126.46, 177.9 64.03, 83.89 -94.43, 31.27 293.9, 81.92 -69.65, -29.63 out-in out 10.018 Saltbr-in 3.599 HRD-in -73.43, -50.53 79.22, -6.25 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -86.17, 94.2 APE9-dihe-na 146.34, 174.25 APE8-dihe-in -131.14, 97.57 APE8-rot-in 299.54 APE67-dihe-out -68.04, -58.6 -56.03, 146.92 APE12-dist-in 10.381 APE11-dist-out 7.186 APE10-dist-in 7.436 APE9-dist-out 8.241 T210V None None XRAY 2.4 0.205 0.235 A 335 292 0 0 0 0 [[53, 305]] 1.0 2ou7 Homo sapiens CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 2V5QA P53350 39 323 603.0 No_ligand No_ligand Inactive DFGin 5.686 14.718 BLAminus -129.1, -167.08 62.93, 75.17 -93.89, 21.76 291.51, 90.84 -61.9, -28.72 out-in out 10.023 Saltbr-in 3.055 HRD-in -67.98, -52.02 73.91, 7.34 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -88.56, 3.75 APE9-dihe-na -179.48, -164.77 APE8-dihe-in -107.94, 115.2 APE8-rot-in 298.84 APE67-dihe-out -71.25, -55.87 -61.61, 160.98 APE12-dist-in 10.438 APE11-dist-out 6.237 APE10-dist-in 5.122 APE9-dist-out 8.333 None None None XRAY 2.3 0.184 0.224 A 315 285 0 0 0 0 [[53, 305]] 1.0 2v5q Homo sapiens CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 2V5QB P53350 39 323 603.0 No_ligand No_ligand Inactive DFGin 5.685 14.925 BLAminus -131.35, -166.96 60.96, 77.54 -92.83, 32.21 286.27, 87.97 -68.24, -26.27 in-out in 9.999 Saltbr-out 3.841 HRD-in -74.56, -53.71 79.97, 1.03 out-in-out SNCoio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -91.44, 9.2 APE9-dihe-na -170.42, 178.21 APE8-dihe-in -101.74, 116.95 APE8-rot-in 316.2 APE67-dihe-out -61.71, -54.24 -52.66, 144.9 APE12-dist-in 9.991 APE11-dist-out 6.774 APE10-dist-in 6.407 APE9-dist-out 8.407 None None None XRAY 2.3 0.184 0.224 B 315 285 0 0 0 0 [[53, 305]] 1.0 2v5q Homo sapiens CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 2YACA P53350 39 329 603.0 937:501 Type1 Inactive DFGin 5.716 14.305 BLAminus -136.25, -176.52 54.6, 87.71 -92.92, 28.24 289.9, 84.23 -75.6, -9.88 in-in in 9.414 Saltbr-in 2.832 HRD-in -79.87, -54.28 83.91, -4.3 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_ioio APE10-dihe-na -90.18, 95.11 APE9-dihe-na 155.4, 174.07 APE8-dihe-in -130.99, 84.18 APE8-rot-out 67.16 APE67-dihe-out -74.05, -70.88 -62.65, 161.23 APE12-dist-in 11.068 APE11-dist-out 7.321 APE10-dist-in 7.625 APE9-dist-out 8.136 None None None XRAY 2.2 0.213 0.255 A 311 291 0 0 0 0 [[53, 305]] 1.0 2yac Homo sapiens CAMK_PLK1_HUMAN CAMK 2.5e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 3KB7A P53350 39 328 603.0 071:1 Type1 Inactive DFGin 5.709 14.042 BLAminus -133.88, 179.17 62.15, 88.77 -94.79, 24.7 288.92, 88.27 -73.01, -6.62 in-in in 8.887 Saltbr-in 2.674 HRD-in -67.89, -55.24 69.06, -3.76 in-in-out SNCiio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iooo APE10-dihe-na -99.22, 86.88 APE9-dihe-na 165.83, 172.24 APE8-dihe-in -120.96, 91.28 APE8-rot-out 68.09 APE67-dihe-out -76.36, -59.91 -62.3, 158.23 APE12-dist-in 11.13 APE11-dist-out 7.377 APE10-dist-out 8.077 APE9-dist-out 8.17 None None NMM324 XRAY 2.5 0.212 0.303 A 311 290 0 0 0 0 [[53, 305]] 1.0 3kb7 Homo sapiens CAMK_PLK1_HUMAN CAMK 2.5e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 4A4LA P53350 39 329 603.0 939:1331 Type1 Inactive DFGin 5.78 14.135 BLAminus -141.7, -176.08 58.67, 82.87 -91.4, 34.14 289.94, 83.08 -71.42, -15.93 in-in in 9.42 Saltbr-in 2.94 HRD-in -74.58, -53.49 81.34, -4.51 in-in-out SNCiio in-out ActLoopNT-in 2.917 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_ioio APE10-dihe-na -83.54, 86.55 APE9-dihe-na 154.14, -178.12 APE8-dihe-in -129.31, 90.58 APE8-rot-out 60.31 APE67-dihe-out -60.53, -82.61 -62.07, 154.01 APE12-dist-in 11.059 APE11-dist-out 7.324 APE10-dist-in 7.616 APE9-dist-out 8.427 None None None XRAY 2.35 0.224 0.274 A 311 291 0 0 0 0 [[53, 305]] 1.0 4a4l Homo sapiens CAMK_PLK1_HUMAN CAMK 2.5e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 4A4OA P53350 39 329 603.0 664:1332 Type1 Inactive DFGin 5.643 14.005 BLAminus -140.91, 173.61 55.04, 90.94 -98.45, 26.61 287.86, 85.19 -77.07, -1.22 in-in in 9.339 Saltbr-in 3.348 HRD-in -69.08, -52.1 82.91, 0.02 in-in-out SNCiio in-out ActLoopNT-in 3.005 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -84.2, 81.23 APE9-dihe-na 164.33, -176.93 APE8-dihe-in -120.87, 80.43 APE8-rot-in 310.59 APE67-dihe-out -59.02, -78.88 -57.5, 148.27 APE12-dist-in 11.161 APE11-dist-out 7.22 APE10-dist-in 7.762 APE9-dist-out 8.205 None None None XRAY 2.7 0.23 0.282 A 311 291 0 0 0 0 [[53, 305]] 1.0 4a4o Homo sapiens CAMK_PLK1_HUMAN CAMK 2.5e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 9R8BA P53350 37 326 603.0 A1JCP:1001 Type1 Inactive DFGin 5.764 14.419 BLAminus -135.37, -173.77 58.86, 75.37 -91.12, 20.8 284.65, 94.62 -63.52, -25.59 in-in in 8.49 Saltbr-in 2.716 HRD-in -71.84, -53.97 76.03, -0.52 in-in-out SNCiio in-out ActLoopNT-in 3.015 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -85.35, 5.7 APE9-dihe-na -171.65, -172.53 APE8-dihe-in -108.35, 119.77 APE8-rot-in 298.21 APE67-dihe-out -65.23, -55.38 -66.82, 157.06 APE12-dist-in 10.619 APE11-dist-out 6.937 APE10-dist-in 5.948 APE9-dist-out 8.318 None None None XRAY 2.2 0.191 0.238 A 315 290 0 0 0 0 [[53, 305]] 1.0 9r8b Homo sapiens CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 9R8BB P53350 37 323 603.0 A1JCP:402 Type1 Inactive DFGin 5.835 14.292 BLAminus -131.75, -174.5 64.87, 76.68 -96.77, 19.5 288.39, 99.04 -77.27, -4.94 in-in in 8.12 Saltbr-in 2.754 HRD-out -68.92, 136.67 -118.63, -11.46 in-in-out SNCiio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na 86.04, 0.68 APE9-dihe-na 169.71, -156.66 APE8-dihe-in -118.48, 123.54 APE8-rot-in 319.34 APE67-dihe-out -62.56, -51.97 -66.18, 154.73 APE12-dist-in 10.472 APE11-dist-in 8.19 APE10-dist-in 5.74 APE9-dist-out 9.562 None None None XRAY 2.2 0.191 0.238 B 315 287 0 0 0 0 [[53, 305]] 1.0 9r8b Homo sapiens CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 9R8CA P53350 38 326 603.0 R78:1001 Type1 Inactive DFGin 5.585 14.99 BLAminus -126.1, -176.63 65.4, 78.62 -95.8, 30.2 285.88, 88.19 -70.16, -23.86 in-in in 9.097 Saltbr-in 2.871 HRD-in -73.52, -53.38 78.38, -0.66 in-in-out SNCiio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -86.03, 32.02 APE9-dihe-na 163.26, -177.26 APE8-dihe-in -109.84, 116.09 APE8-rot-in 291.16 APE67-dihe-out -62.02, -59.2 -61.3, 153.09 APE12-dist-in 10.411 APE11-dist-out 6.256 APE10-dist-in 5.762 APE9-dist-out 8.623 None None None XRAY 2.243 0.191 0.236 A 315 289 0 0 0 0 [[53, 305]] 1.0 9r8c Homo sapiens CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 9R8CB P53350 38 323 603.0 R78:1001 Type1 Inactive DFGin 5.546 14.996 BLAminus -130.55, -176.06 59.62, 83.99 -94.79, 30.62 285.83, 86.69 -68.45, -26.03 in-in in 9.151 Saltbr-in 2.768 HRD-in -75.84, -53.52 77.99, 2.7 in-in-out SNCiio in-out ActLoopNT-in 2.953 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -89.08, 50.7 APE9-dihe-na 152.38, 176.7 APE8-dihe-in -113.61, 115.98 APE8-rot-in 316.69 APE67-dihe-out -67.47, -56.35 -62.32, 152.06 APE12-dist-in 9.96 APE11-dist-out 7.059 APE10-dist-in 6.623 APE9-dist-out 8.508 None None None XRAY 2.243 0.191 0.236 B 315 286 0 0 0 0 [[53, 305]] 1.0 9r8c Homo sapiens CAMK_PLK1_HUMAN CAMK 2.6e-79 272.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 4J52A P53350 38 330 603.0 1J3:400 Type1 Inactive DFGin 5.673 14.405 BLAminus -132.19, -178.32 57.1, 88.41 -99.88, 23.54 290.9, 84.86 -66.29, -8.43 in-in in 9.392 Saltbr-in 2.701 HRD-in -83.32, -51.41 78.14, -8.7 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -92.24, 97.88 APE9-dihe-na 154.03, 172.56 APE8-dihe-in -123.15, 84.89 APE8-rot-in 302.52 APE67-dihe-out -69.1, -50.77 -69.03, 151.29 APE12-dist-in 10.979 APE11-dist-out 7.354 APE10-dist-in 7.818 APE9-dist-out 7.821 T210V None None XRAY 2.3 0.198 0.241 A 293 293 0 0 0 0 [[53, 305]] 1.0 4j52 Homo sapiens CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 4J53A P53350 38 330 603.0 1J4:403 Type1 Inactive DFGin 5.64 14.579 BLAminus -129.35, -169.37 44.41, 85.29 -91.22, 24.89 291.84, 82.06 -64.71, -23.25 in-in in 9.981 Saltbr-in 3.01 HRD-in -75.81, -49.76 74.88, 0.23 in-in-out SNCiio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -78.39, 101.76 APE9-dihe-na 146.02, 166.78 APE8-dihe-in -121.83, 82.96 APE8-rot-in 302.16 APE67-dihe-out -75.51, -62.04 -60.01, 151.77 APE12-dist-in 10.953 APE11-dist-out 7.401 APE10-dist-in 7.763 APE9-dist-out 7.856 T210V None None XRAY 2.5 0.183 0.24 A 293 293 0 0 0 0 [[53, 305]] 1.0 4j53 Homo sapiens CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 2RKUA P53350 37 330 603.0 R78:500 Type1 Inactive DFGin 5.678 15.017 BLAminus -134.22, -169.5 54.06, 79.11 -86.67, 25.63 283.82, 88.21 -64.51, -26.07 in-in in 9.717 Saltbr-in 3.08 HRD-in -74.95, -48.26 75.93, -2.57 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -90.21, 90.69 APE9-dihe-na 162.46, 178.28 APE8-dihe-in -124.7, 88.6 APE8-rot-in 309.54 APE67-dihe-out -73.41, -64.04 -71.02, 160.05 APE12-dist-in 10.929 APE11-dist-out 7.283 APE10-dist-in 7.921 APE9-dist-out 8.134 T210V None None XRAY 1.95 0.192 0.241 A 294 294 0 0 0 0 [[53, 305]] 1.0 2rku Homo sapiens CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 8BJTA P53350 39 330 603.0 8X7:402 Type1 Inactive DFGin 5.743 14.312 BLAminus -146.49, -170.45 55.69, 70.04 -90.08, 22.34 281.62, 90.95 -60.02, -37.94 in-in in 9.222 Saltbr-in 2.728 HRD-in -68.54, -47.7 72.42, -10.0 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iooo APE10-dihe-na -90.89, 99.31 APE9-dihe-na 143.06, 169.47 APE8-dihe-in -120.75, 101.21 APE8-rot-out 199.98 APE67-dihe-out -76.79, -55.69 -65.4, 158.12 APE12-dist-in 11.16 APE11-dist-out 7.403 APE10-dist-out 8.236 APE9-dist-out 8.563 None None None XRAY 2.188 0.203 0.255 A 294 292 0 0 0 0 [[53, 305]] 1.0 8bjt Homo sapiens CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 3THBA P53350 42 328 603.0 3TA:1 Type1 Inactive DFGin 5.763 14.246 BLAminus -135.92, -170.43 55.15, 75.45 -87.11, 14.2 290.23, 88.06 -65.07, -8.71 in-in in 9.125 Saltbr-in 3.549 HRD-in -66.85, -49.24 73.84, -10.07 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_ioio APE10-dihe-na -91.42, 101.79 APE9-dihe-na 126.02, 172.43 APE8-dihe-in -121.57, 103.22 APE8-rot-out 68.36 APE67-dihe-out -75.15, -60.09 -61.3, 157.38 APE12-dist-in 11.579 APE11-dist-out 7.552 APE10-dist-in 7.746 APE9-dist-out 8.65 T210V None None XRAY 2.5 0.253 0.286 A 333 287 0 0 0 0 [[53, 305]] 1.0 3thb Homo sapiens CAMK_PLK1_HUMAN CAMK 1.7e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 2OWBA P53350 37 330 603.0 626:500 Type1 Inactive DFGin 5.741 14.273 BLAminus -131.62, -172.7 55.05, 82.45 -94.97, 27.99 289.46, 84.52 -70.38, -17.86 in-in in 9.505 Saltbr-in 2.635 HRD-in -72.25, -49.78 72.96, -0.12 in-in-out SNCiio in-out ActLoopNT-in 3.006 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -85.58, 102.01 APE9-dihe-na 139.92, 169.2 APE8-dihe-in -127.98, 85.88 APE8-rot-in 302.45 APE67-dihe-out -70.16, -61.75 -57.83, 150.59 APE12-dist-in 10.943 APE11-dist-out 7.422 APE10-dist-in 7.619 APE9-dist-out 7.979 T210V None None XRAY 2.1 0.205 0.243 A 335 294 0 0 0 0 [[53, 305]] 1.0 2owb Homo sapiens CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 3FC2A P53350 37 329 603.0 IBI:10 Type1 Inactive DFGin 5.687 14.844 BLAminus -136.2, -169.15 47.8, 83.29 -92.73, 30.51 290.96, 88.11 -72.2, -20.77 in-in in 9.845 Saltbr-in 2.787 HRD-in -72.68, -50.74 75.03, 6.56 in-in-out SNCiio in-out ActLoopNT-in 2.972 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -91.8, 110.95 APE9-dihe-na 128.06, 168.28 APE8-dihe-in -129.49, 88.48 APE8-rot-in 292.3 APE67-dihe-out -76.49, -62.11 -61.16, 163.08 APE12-dist-in 11.004 APE11-dist-out 7.364 APE10-dist-in 7.532 APE9-dist-out 7.885 T210V None None XRAY 2.45 0.184 0.226 A 335 293 0 0 0 0 [[53, 305]] 1.0 3fc2 Homo sapiens CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 9D0PA P53350 37 330 603.0 8X7:401 Type1 Inactive DFGin 5.932 14.467 BLAminus -127.97, -167.66 73.35, 57.17 -81.61, 36.59 285.64, 88.68 -94.22, -12.32 in-in in 9.093 Saltbr-in 2.758 HRD-in -81.82, -53.71 82.64, -7.07 in-in-out SNCiio in-out ActLoopNT-in 2.912 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -92.87, 112.89 APE9-dihe-na 127.84, 173.17 APE8-dihe-in -124.26, 98.89 APE8-rot-in 301.22 APE67-dihe-out -72.74, -55.92 -71.3, 155.26 APE12-dist-in 11.296 APE11-dist-out 7.351 APE10-dist-in 7.483 APE9-dist-out 8.252 T210V None None XRAY 2.65 0.247 0.29 A 335 294 0 0 0 0 [[53, 305]] 1.0 9d0p Homo sapiens CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 9R1WAAA P53350 38 334 603.0 A1JCP:401 Type1 Inactive DFGin 5.629 14.307 BLAminus -134.11, -168.09 56.45, 78.1 -90.07, 23.96 287.47, 94.05 -61.0, -27.64 in-in in 9.056 Saltbr-in 2.817 HRD-in -73.41, -49.99 71.11, 3.55 in-in-out SNCiio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -89.16, 9.34 APE9-dihe-na -169.47, 176.32 APE8-dihe-in -98.59, 112.0 APE8-rot-in 302.37 APE67-dihe-out -62.18, -51.19 -58.71, 150.32 APE12-dist-in 10.183 APE11-dist-out 6.559 APE10-dist-in 6.236 APE9-dist-out 8.502 K225D,K226A None None XRAY 2.2 0.18 0.216 AAA 325 297 0 0 0 0 [[53, 305]] 1.0 9r1w Homo sapiens CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 9R1WBBB P53350 38 325 603.0 A1JCP:401 Type1 Inactive DFGin 5.63 14.351 BLAminus -133.86, -166.71 56.12, 78.59 -90.53, 23.21 288.19, 92.88 -61.02, -27.23 in-in in 9.229 Saltbr-in 2.745 HRD-in -73.38, -50.78 71.42, 4.57 in-in-out SNCiio in-out ActLoopNT-in 2.97 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -89.57, 8.7 APE9-dihe-na -168.16, 173.41 APE8-dihe-in -98.08, 111.85 APE8-rot-in 305.79 APE67-dihe-out -62.5, -50.96 -59.11, 151.11 APE12-dist-in 10.072 APE11-dist-out 6.598 APE10-dist-in 6.18 APE9-dist-out 8.439 K225D,K226A None None XRAY 2.2 0.18 0.216 BBB 325 288 0 0 0 0 [[53, 305]] 1.0 9r1w Homo sapiens CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 9R1XA P53350 39 334 603.0 R78:401 Type1 Inactive DFGin 5.451 14.746 BLAminus -129.34, -169.27 61.33, 81.84 -99.46, 30.78 291.65, 94.79 -60.61, -43.02 in-in in 9.685 Saltbr-in 2.721 HRD-in -71.39, -48.31 73.02, 3.83 in-in-out SNCiio in-out ActLoopNT-in 2.971 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -86.63, 46.88 APE9-dihe-na 161.22, 163.69 APE8-dihe-in -103.28, 108.1 APE8-rot-in 301.35 APE67-dihe-out -58.97, -56.16 -54.1, 148.74 APE12-dist-in 10.388 APE11-dist-out 6.56 APE10-dist-in 6.741 APE9-dist-out 8.509 K225D,K226A None None XRAY 2.84 0.222 0.277 A 325 296 0 0 0 0 [[53, 305]] 1.0 9r1x Homo sapiens CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 9R1XB P53350 39 326 603.0 R78:401 Type1 Inactive DFGin 5.445 14.726 BLAminus -129.89, -169.09 62.76, 81.42 -99.44, 28.81 292.45, 94.66 -58.03, -43.63 in-in in 9.666 Saltbr-in 2.714 HRD-in -71.6, -47.96 72.32, 5.61 in-in-out SNCiio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -82.43, 34.44 APE9-dihe-na 160.48, 165.73 APE8-dihe-in -102.91, 108.17 APE8-rot-in 301.26 APE67-dihe-out -58.46, -55.69 -54.97, 148.64 APE12-dist-in 10.404 APE11-dist-out 6.532 APE10-dist-in 5.999 APE9-dist-out 8.447 K225D,K226A None None XRAY 2.84 0.222 0.277 B 325 288 0 0 0 0 [[53, 305]] 1.0 9r1x Homo sapiens CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 9R1YAAA P53350 38 334 603.0 A1JCQ:401 Type1 Inactive DFGin 5.493 14.267 BLAminus -126.75, -172.44 65.19, 77.92 -95.78, 35.59 294.04, 83.7 -66.64, -28.98 in-in in 9.464 Saltbr-in 2.744 HRD-in -71.96, -50.24 71.88, 5.14 in-in-out SNCiio in-out ActLoopNT-in 3.103 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -88.57, 8.2 APE9-dihe-na -166.23, -178.27 APE8-dihe-in -105.79, 106.71 APE8-rot-in 300.95 APE67-dihe-out -66.32, -52.43 -54.05, 151.38 APE12-dist-in 10.28 APE11-dist-out 6.494 APE10-dist-in 6.137 APE9-dist-out 8.38 K225D,K226A None None XRAY 2.602 0.187 0.218 AAA 325 297 0 0 0 0 [[53, 305]] 1.0 9r1y Homo sapiens CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 9R1YBBB P53350 38 325 603.0 A1JCQ:401 Type1 Inactive DFGin 5.517 14.349 BLAminus -126.84, -171.95 66.19, 77.61 -96.17, 35.42 294.69, 83.98 -66.59, -29.54 in-in in 9.503 Saltbr-in 2.744 HRD-in -72.69, -50.41 71.98, 5.19 in-in-out SNCiio in-out ActLoopNT-in 3.11 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -88.39, 7.64 APE9-dihe-na -166.1, -178.49 APE8-dihe-in -105.58, 106.71 APE8-rot-in 302.14 APE67-dihe-out -65.99, -51.73 -54.43, 151.5 APE12-dist-in 10.301 APE11-dist-out 6.48 APE10-dist-in 5.991 APE9-dist-out 8.363 K225D,K226A None None XRAY 2.602 0.187 0.218 BBB 325 288 0 0 0 0 [[53, 305]] 1.0 9r1y Homo sapiens CAMK_PLK1_HUMAN CAMK 1.1e-78 270.0 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 5TA6A P53350 37 330 603.0 79D:1000 Type1 Inactive DFGin 5.768 14.691 BLAminus -129.81, 178.93 63.79, 86.6 -95.82, 28.6 292.13, 79.82 -68.79, -23.38 in-in in 9.776 Saltbr-in 3.06 HRD-in -68.63, -52.95 71.96, 8.35 in-in-out SNCiio in-out ActLoopNT-in 2.889 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_ioio APE10-dihe-na -85.92, 111.12 APE9-dihe-na 138.09, 164.23 APE8-dihe-in -126.56, 95.9 APE8-rot-out 85.27 APE67-dihe-out -71.06, -59.19 -57.19, 156.45 APE12-dist-in 10.908 APE11-dist-out 7.328 APE10-dist-in 7.694 APE9-dist-out 7.599 None None None XRAY 2.5 0.183 0.26 A 358 294 0 0 0 0 [[53, 305]] 1.0 5ta6 Homo sapiens CAMK_PLK1_HUMAN CAMK 2.2e-78 269.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
PLK1_HUMAN 5TA8A P53350 37 330 603.0 79C:402 Type1 Inactive DFGin 5.598 14.311 BLAminus -141.08, -172.7 51.52, 90.37 -96.67, 41.3 290.69, 89.43 -72.33, -19.61 in-in in 9.107 Saltbr-in 2.727 HRD-in -66.37, -49.24 72.53, -11.97 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_ioio APE10-dihe-na -88.19, 81.36 APE9-dihe-na 134.61, 175.47 APE8-dihe-in -125.29, 109.1 APE8-rot-out 49.04 APE67-dihe-out -73.09, -62.08 -71.65, 169.34 APE12-dist-in 10.81 APE11-dist-out 7.473 APE10-dist-in 7.188 APE9-dist-out 8.693 None None None XRAY 2.6 0.185 0.247 A 358 294 0 0 0 0 [[53, 305]] 1.0 5ta8 Homo sapiens CAMK_PLK1_HUMAN CAMK 2.2e-78 269.1 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1

CAMK_PLK1 (Serine/threonine-protein kinase PLK1)

Total number of chains: 12
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 91.7% 3D5UA
DFGin ABAminus 1 8.3% 4J7BD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
Q6DRK7_DANRE 4J7BD Q6DRK7 20 311 595.0 No_ligand No_ligand Inactive DFGin 5.487 14.555 ABAminus -129.81, -7.43 -133.83, 113.48 -107.04, 20.33 291.52, 92.27 -51.62, -38.38 out-in out 10.214 Saltbr-in 2.966 HRD-in -68.9, -50.24 76.71, 4.14 in-in-out SNCiio in-out ActLoopNT-in 2.745 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.82 APE8-dihe-in -131.87, 100.17 APE8-rot-in 301.55 APE67-dihe-out -78.82, -54.23 -64.35, 166.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.947 D162N,E192F None None XRAY 2.3 0.208 0.264 D 297 281 11 0 0 11 [[39, 291]] 1.0 4j7b Danio rerio CAMK_PLK1_DANRE CAMK 8.1e-76 260.6 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3D5WA Q4KMI8 24 310 595.0 ADP:313 ATPlike Inactive DFGin 5.84 15.103 BLAminus -136.31, -173.3 52.58, 90.43 -100.9, 29.72 290.61, 88.81 -67.31, -18.54 out-out out 10.538 Saltbr-out 4.57 HRD-in -72.81, -47.33 67.56, -5.93 out-in-in SNCoii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.0, 153.74 APE9-dihe-na 145.11, -167.91 APE8-dihe-in -110.25, 127.19 APE8-rot-in 299.86 APE67-dihe-in -70.02, -15.96 -37.98, -47.89 APE12-dist-in 8.251 APE11-dist-in 11.275 APE10-dist-in 5.646 APE9-dist-in 3.912 None TPO196 TPO196 XRAY 2.6 0.244 0.271 A 317 285 2 0 0 0 [[39, 291]] 1.0 3d5w Danio rerio CAMK_PLK1_DANRE CAMK 4.6e-77 264.7 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q6DRK7_DANRE 3D5UA Q6DRK7 23 310 595.0 No_ligand No_ligand Inactive DFGin 5.693 14.809 BLAminus -132.0, -170.66 53.21, 91.71 -105.63, 34.97 291.53, 90.32 -70.7, -17.69 out-out out 10.7 Saltbr-out 4.35 HRD-in -73.43, -47.86 66.94, -9.91 out-in-out SNCoio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -83.53, 77.69 APE9-dihe-na 160.43, 176.55 APE8-dihe-in -120.81, 90.57 APE8-rot-in 316.96 APE67-dihe-out -68.11, -72.46 -73.03, 158.49 APE12-dist-in 10.666 APE11-dist-out 7.401 APE10-dist-in 7.522 APE9-dist-out 8.466 None None None XRAY 2.8 0.231 0.281 A 317 288 0 0 0 0 [[39, 291]] 1.0 3d5u Danio rerio CAMK_PLK1_DANRE CAMK 4.6e-77 264.7 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q6DRK7_DANRE 4J7BA Q6DRK7 18 311 595.0 No_ligand No_ligand Inactive DFGin 5.957 14.822 BLAminus -127.79, -166.66 63.28, 73.86 -94.07, 24.02 287.22, 93.09 -58.39, -32.32 in-in in 9.948 Saltbr-in 2.526 HRD-in -69.09, -53.7 77.98, -8.47 in-in-out SNCiio in-out ActLoopNT-in 2.814 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnio APE10-dihe-na 999.0, 170.84 APE9-dihe-na -82.59, -164.35 APE8-dihe-in -106.73, 113.42 APE8-rot-out 172.88 APE67-dihe-out -56.23, -64.85 -68.6, 152.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.933 APE9-dist-out 8.473 D162N,E192F None None XRAY 2.3 0.208 0.264 A 297 284 10 0 0 10 [[39, 291]] 1.0 4j7b Danio rerio CAMK_PLK1_DANRE CAMK 8.1e-76 260.6 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3D5XA Q4KMI8 24 309 595.0 KWT:1 Type1 Inactive DFGin 5.748 14.936 BLAminus -139.39, -170.01 59.65, 84.09 -100.6, 25.02 290.64, 93.65 -64.4, -14.86 out-out out 10.666 Saltbr-out 4.394 HRD-in -69.94, -48.19 73.11, -11.18 out-in-none SNCoin in-none ActLoopNT-in 3.068 ActLoopCT-none nonTYR APEdihe_aannn APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-in 10.296 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 2.8 0.263 0.299 A 301 279 7 0 0 7 [[39, 291]] 1.0 3d5x Danio rerio CAMK_PLK1_DANRE CAMK 8.9e-77 263.8 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DBEA Q4KMI8 24 310 595.0 4FR:1 Type1 Inactive DFGin 5.33 14.261 BLAminus -130.08, -172.43 53.96, 104.63 -115.22, 13.87 295.84, 91.17 -49.61, -15.58 out-out out 10.073 Saltbr-out 4.367 HRD-in -75.7, -52.21 77.46, -22.23 out-in-out SNCoio in-out ActLoopNT-in 2.969 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ionn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -89.97, -74.84 999.0, 157.6 APE12-dist-in 10.405 APE11-dist-out 7.734 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 3.32 0.237 0.27 A 301 284 3 0 0 3 [[39, 291]] 1.0 3dbe Danio rerio CAMK_PLK1_DANRE CAMK 8.9e-77 263.8 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DBFA Q4KMI8 24 310 595.0 5FR:1 Type1 Inactive DFGin 5.569 14.507 BLAminus -126.48, -167.26 59.45, 92.34 -110.0, 25.26 297.55, 90.95 -54.7, -27.45 in-out in 9.878 Saltbr-out 4.027 HRD-in -77.45, -40.3 68.16, -16.48 out-in-none SNCoin in-none ActLoopNT-in 2.929 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 3.2 0.234 0.275 A 301 261 26 0 0 20 [[39, 291]] 1.0 3dbf Danio rerio CAMK_PLK1_DANRE CAMK 8.9e-77 263.8 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DB8A Q4KMI8 24 310 595.0 1FR:313 Type1 Inactive DFGin 5.759 14.657 BLAminus -132.17, -175.89 60.33, 81.89 -97.25, 28.2 286.75, 81.14 -57.5, -31.84 in-out in 9.909 Saltbr-out 3.829 HRD-in -71.72, -45.68 69.14, -18.96 out-in-none SNCoin in-none ActLoopNT-in 2.828 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 3.15 0.232 0.274 A 317 261 26 0 0 20 [[39, 291]] 1.0 3db8 Danio rerio CAMK_PLK1_DANRE CAMK 1.1e-76 263.5 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DBCA Q4KMI8 24 310 595.0 2FR:313 Type1 Inactive DFGin 5.734 14.664 BLAminus -136.39, -168.79 53.28, 74.51 -89.66, 27.23 289.49, 88.8 -63.71, -13.19 in-out in 9.639 Saltbr-out 4.056 HRD-in -85.71, -43.45 67.47, -24.22 out-in-none SNCoin in-none ActLoopNT-in 3.018 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 3.35 0.245 0.288 A 317 261 26 0 0 20 [[39, 291]] 1.0 3dbc Danio rerio CAMK_PLK1_DANRE CAMK 1.1e-76 263.5 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DBDA Q4KMI8 24 310 595.0 3FR:313 Type1 Inactive DFGin 5.909 14.941 BLAminus -134.29, -167.77 57.39, 80.83 -100.95, 31.61 290.61, 85.71 -63.54, -20.94 out-out out 10.044 Saltbr-out 4.299 HRD-in -65.46, -53.96 81.32, -10.52 out-in-none SNCoin in-none ActLoopNT-in 2.867 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 3.05 0.252 0.276 A 317 261 26 0 0 20 [[39, 291]] 1.0 3dbd Danio rerio CAMK_PLK1_DANRE CAMK 1.1e-76 263.5 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q4KMI8_DANRE 3DB6A Q4KMI8 24 310 595.0 FRS:1 Type1.5_Front Inactive DFGin 5.817 15.954 BLAminus -142.4, -169.51 60.61, 84.89 -102.5, 26.5 287.92, 83.73 -63.45, -15.75 out-out out 11.643 Saltbr-out 7.205 HRD-in -75.01, -40.51 67.41, -16.08 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -91.76, 87.23 APE9-dihe-na 133.88, 161.1 APE8-dihe-in -107.95, 116.2 APE8-rot-in 306.39 APE67-dihe-out -75.67, -58.88 -71.76, 164.15 APE12-dist-in 11.272 APE11-dist-out 7.484 APE10-dist-in 7.511 APE9-dist-out 8.776 T196D None None XRAY 2.85 0.225 0.257 A 301 287 0 0 0 0 [[39, 291]] 1.0 3db6 Danio rerio CAMK_PLK1_DANRE CAMK 8.9e-77 263.8 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
Q6DRK7_DANRE 3D5VA Q6DRK7 25 312 595.0 No_ligand No_ligand None DFGin 5.892 14.868 BLAminus -136.77, -170.94 58.3, 78.56 -96.91, 24.94 292.69, 93.45 -65.35, -19.51 out-in out 10.405 Saltbr-in 3.408 HRD-in -70.1, -47.78 72.09, -9.5 in-in-none SNCiin in-none ActLoopNT-in 2.884 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T196D None None XRAY 2.4 0.237 0.269 A 317 260 28 0 0 19 [[39, 291]] 1.0 3d5v Danio rerio CAMK_PLK1_DANRE CAMK 1.1e-76 263.5 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK