STE_PAK2 (Serine/threonine-protein kinase PAK 2)

Total number of chains: 10
Active chains: 2
Uniprot: PAK2_HUMAN
Kinase Domain Residues: 249 - 499
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 30.0% AF-Q13177-K1A
DFGin BLAplus 3 30.0% 9LBGA
DFGin BLBplus 2 20.0% 9D51B
DFGout BBAminus 1 10.0% 9M41A
DFGout None 1 10.0% 9M41B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PAK2 AF-Q13177-K1A Q13177 241 507 524.0 No_ligand No_ligand Active DFGin 6.1059 14.1768 BLAminus -135.07, -175.85 58.55, 59.21 -73.59, 13.06 296.91, 90.17 -57.5, -32.35 in-in in 8.5537 Saltbr-in 2.6615 HRD-in -71.74, -47.32 65.15, 10.01 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.9, 154.76 APE9-dihe-na 122.93, 169.69 APE8-dihe-in -75.49, 126.8 APE8-rot-in 301.61 APE67-dihe-in -71.28, -19.99 -49.18, -46.82 APE12-dist-in 9.1369 APE11-dist-in 11.7377 APE10-dist-in 5.9107 APE9-dist-in 3.2627 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 28 28 0 [[249, 500]] 1.0 AF-Q13177-K1 STE_PAK2_HUMAN STE 8.1e-94 319.7 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 AF-Q13177-K3A Q13177 241 507 524.0 No_ligand No_ligand Active DFGin 6.0202 14.7686 BLAminus -139.09, -177.01 63.44, 60.48 -79.31, 6.7 296.85, 88.93 -60.63, -34.09 in-in in 9.1588 Saltbr-in 2.9611 HRD-in -72.87, -48.71 68.14, 8.1 in-in-in SNCiii in-in ActLoopNT-in 2.8653 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.83, 137.26 APE9-dihe-na 124.91, 173.85 APE8-dihe-in -83.8, 128.3 APE8-rot-in 305.88 APE67-dihe-in -64.82, -24.49 -41.62, -53.25 APE12-dist-in 9.8558 APE11-dist-in 11.8781 APE10-dist-in 5.9658 APE9-dist-in 3.0319 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 28 28 0 [[249, 500]] 1.0 AF-Q13177-K3 STE_PAK2_HUMAN STE 8.1e-94 319.7 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 9D51A Q13177 230 523 524.0 A1A2Q:601 Type1 Inactive DFGin 6.8219 14.5788 BLAminus -155.68, -177.12 53.06, 83.32 -103.92, 22.39 298.47, 78.95 -74.5, -13.78 in-out in 9.8522 Saltbr-out 4.8692 HRD-in -82.04, -50.53 71.3, -6.01 out-in-in SNCoii in-in ActLoopNT-in 2.7358 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.33, 143.33 APE9-dihe-na 133.67, -179.52 APE8-dihe-in -102.94, 126.72 APE8-rot-in 307.45 APE67-dihe-in -60.66, -27.49 -40.35, -53.95 APE12-dist-in 10.2321 APE11-dist-in 12.0439 APE10-dist-in 6.4214 APE9-dist-in 3.3192 D368N,T402E,P498Q,M514A None None XRAY 2.1 0.215 0.285 A 297.0 289.0 5 28 23 5 [[249, 500]] 1.0 9d51 STE_PAK2_HUMAN STE 2.5e-92 314.8 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 9LBGB Q13177 91 522 524.0 MLT:601 Allosteric Inactive DFGin 7.3435 15.3775 BLAplus -148.26, 179.51 67.37, 35.52 -105.65, 12.32 43.07, 76.53 -162.93, -168.03 out-none out 11.4982 Saltbr-none 999.0 HRD-in -75.52, -44.19 73.12, -22.5 none-out-out SNCnoo out-out ActLoopNT-out 13.07 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 70.38 APE8-rot-out 40.39 APE67-dihe-out -59.74, -24.06 -87.06, 54.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K278R None None XRAY 2.89 0.197 0.233 B 466.0 336.0 10 28 18 10 [[249, 500]] 1.0 9lbg STE_PAK2_HUMAN STE 1.7e-92 315.7 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 9LBGA Q13177 84 522 524.0 No_ligand No_ligand Inactive DFGin 7.2462 13.2399 BLAplus -134.8, 169.74 69.29, 40.07 -99.67, -19.31 46.77, 86.97 -137.31, -170.73 out-none out 10.5922 Saltbr-none 999.0 HRD-in -69.25, -50.33 80.39, -13.72 none-out-out SNCnoo out-out ActLoopNT-out 11.5425 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 140.98 APE9-dihe-na 66.3, -179.07 APE8-dihe-in -110.51, 131.01 APE8-rot-out 171.97 APE67-dihe-out -62.5, -23.12 -83.48, 66.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.1508 APE9-dist-out 13.6894 K278R None None XRAY 2.89 0.197 0.233 A 466.0 351.0 7 28 21 7 [[249, 500]] 1.0 9lbg STE_PAK2_HUMAN STE 1.7e-92 315.7 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 9LBFA Q13177 86 522 524.0 No_ligand No_ligand Inactive DFGin 7.8448 13.6141 BLAplus -139.51, 166.88 74.2, 35.56 -96.67, -31.69 40.66, 100.7 -123.09, -146.04 out-out out 11.1426 Saltbr-out 7.8631 HRD-in -64.29, -56.59 86.77, -3.8 out-out-out SNCooo out-out ActLoopNT-out 11.6767 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoo APE10-dihe-na 999.0, -26.57 APE9-dihe-na 176.19, -152.47 APE8-dihe-in -84.91, 126.9 APE8-rot-in 306.43 APE67-dihe-out -58.07, -24.38 -83.02, 68.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.6347 APE9-dist-out 13.9739 D368N None None XRAY 2.62 0.199 0.222 A 479.0 351.0 8 28 20 8 [[249, 500]] 1.0 9lbf STE_PAK2_HUMAN STE 4.2e-92 314.4 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 9LBFB Q13177 93 522 524.0 No_ligand No_ligand Inactive DFGin 7.0308 16.6912 BLBplus -134.23, -173.46 72.48, 42.23 -141.91, 145.41 70.0, 102.23 66.59, -144.55 out-out out 11.2269 Saltbr-out 9.4629 HRD-in -79.1, -48.8 75.21, -20.52 out-out-out SNCooo out-out ActLoopNT-out 12.1265 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.12 APE8-rot-in 303.98 APE67-dihe-out -61.34, -24.51 -89.78, 56.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D368N None None XRAY 2.62 0.199 0.222 B 479.0 324.0 14 28 14 14 [[249, 500]] 1.0 9lbf STE_PAK2_HUMAN STE 4.2e-92 314.4 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 9D51B Q13177 231 522 524.0 A1A2Q:601 Type1 Inactive DFGin 7.4627 14.6272 BLBplus -148.89, 171.4 55.47, 51.12 -127.9, 150.94 47.62, 98.01 -123.17, -151.45 out-out out 12.7071 Saltbr-out 7.4493 HRD-in -83.39, -45.71 84.58, -20.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -102.48, -50.47 APE9-dihe-na -87.43, 155.09 APE8-dihe-in -94.3, 130.54 APE8-rot-in 291.03 APE67-dihe-out -70.68, -23.25 -91.81, 72.44 APE12-dist-out 25.9945 APE11-dist-out 22.8678 APE10-dist-out 24.1234 APE9-dist-out 13.675 D368N,T402E,P498Q,M514A None None XRAY 2.1 0.215 0.285 B 297.0 288.0 4 28 24 4 [[249, 500]] 1.0 9d51 STE_PAK2_HUMAN STE 2.5e-92 314.8 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 9M41A Q13177 85 520 524.0 No_ligand No_ligand Inactive DFGout 12.6843 9.0142 BBAminus -125.12, 135.19 -131.33, 83.56 -80.02, -27.51 287.94, 159.18 -71.75, -11.49 out-none out 11.1819 Saltbr-none 999.0 HRD-in -73.25, -40.38 68.65, -7.58 none-out-out SNCnoo out-out ActLoopNT-out 4.847 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -90.46, 3.09 APE9-dihe-na 125.79, -159.31 APE8-dihe-in -79.99, 115.22 APE8-rot-in 285.02 APE67-dihe-out -64.36, -25.19 -89.83, 65.97 APE12-dist-out 16.0864 APE11-dist-out 15.2925 APE10-dist-out 11.2605 APE9-dist-out 11.4899 K278R,D368N None None XRAY 3.02 0.206 0.244 A 547.0 340.0 4 28 24 4 [[249, 500]] 1.0 9m41 STE_PAK2_HUMAN STE 2.1e-91 312.3 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 9M41B Q13177 83 521 524.0 No_ligand No_ligand Inactive DFGout 14.6841 8.8721 None -119.07, 158.3 -116.1, 82.98 -67.22, 153.05 292.21, 125.16 75.02, -7.43 out-none out 12.0054 Saltbr-none 999.0 HRD-in -63.31, -45.58 68.96, -6.32 none-out-out SNCnoo out-out ActLoopNT-out 4.7448 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -164.74 APE8-dihe-in -105.73, 116.09 APE8-rot-in 316.87 APE67-dihe-out -63.1, -27.55 -87.37, 73.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.4544 K278R,D368N None None XRAY 3.02 0.206 0.244 B 547.0 342.0 7 28 21 7 [[249, 500]] 1.0 9m41 STE_PAK2_HUMAN STE 2.1e-91 312.3 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2

STE_PAK2 (Serine/threonine-protein kinase PAK 2)

Total number of chains: 10
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 30.0% AF-Q13177-K1A
DFGin BLAplus 3 30.0% 9LBGA
DFGin BLBplus 2 20.0% 9D51B
DFGout BBAminus 1 10.0% 9M41A
DFGout None 1 10.0% 9M41B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PAK2 PAK2_HUMAN AF-Q13177-K1A Q13177 241 507 524.0 No_ligand No_ligand Active DFGin 6.1059 14.1768 BLAminus -135.07, -175.85 58.55, 59.21 -73.59, 13.06 296.91, 90.17 -57.5, -32.35 in-in in 8.5537 Saltbr-in 2.6615 HRD-in -71.74, -47.32 65.15, 10.01 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.9, 154.76 APE9-dihe-na 122.93, 169.69 APE8-dihe-in -75.49, 126.8 APE8-rot-in 301.61 APE67-dihe-in -71.28, -19.99 -49.18, -46.82 APE12-dist-in 9.1369 APE11-dist-in 11.7377 APE10-dist-in 5.9107 APE9-dist-in 3.2627 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 28 28 0 [[249, 500]] 1.0 AF-Q13177-K1 Homo sapiens STE_PAK2_HUMAN STE 8.1e-94 319.7 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 PAK2_HUMAN AF-Q13177-K3A Q13177 241 507 524.0 No_ligand No_ligand Active DFGin 6.0202 14.7686 BLAminus -139.09, -177.01 63.44, 60.48 -79.31, 6.7 296.85, 88.93 -60.63, -34.09 in-in in 9.1588 Saltbr-in 2.9611 HRD-in -72.87, -48.71 68.14, 8.1 in-in-in SNCiii in-in ActLoopNT-in 2.8653 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.83, 137.26 APE9-dihe-na 124.91, 173.85 APE8-dihe-in -83.8, 128.3 APE8-rot-in 305.88 APE67-dihe-in -64.82, -24.49 -41.62, -53.25 APE12-dist-in 9.8558 APE11-dist-in 11.8781 APE10-dist-in 5.9658 APE9-dist-in 3.0319 None None None AF2 -1.0 1.0 1.0 A 267.0 267.0 0 28 28 0 [[249, 500]] 1.0 AF-Q13177-K3 Homo sapiens STE_PAK2_HUMAN STE 8.1e-94 319.7 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 PAK2_HUMAN 9D51A Q13177 230 523 524.0 A1A2Q:601 Type1 Inactive DFGin 6.8219 14.5788 BLAminus -155.68, -177.12 53.06, 83.32 -103.92, 22.39 298.47, 78.95 -74.5, -13.78 in-out in 9.8522 Saltbr-out 4.8692 HRD-in -82.04, -50.53 71.3, -6.01 out-in-in SNCoii in-in ActLoopNT-in 2.7358 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.33, 143.33 APE9-dihe-na 133.67, -179.52 APE8-dihe-in -102.94, 126.72 APE8-rot-in 307.45 APE67-dihe-in -60.66, -27.49 -40.35, -53.95 APE12-dist-in 10.2321 APE11-dist-in 12.0439 APE10-dist-in 6.4214 APE9-dist-in 3.3192 D368N,T402E,P498Q,M514A None None XRAY 2.1 0.215 0.285 A 297.0 289.0 5 28 23 5 [[249, 500]] 1.0 9d51 Homo sapiens STE_PAK2_HUMAN STE 2.5e-92 314.8 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 PAK2_HUMAN 9LBGB Q13177 91 522 524.0 MLT:601 Allosteric Inactive DFGin 7.3435 15.3775 BLAplus -148.26, 179.51 67.37, 35.52 -105.65, 12.32 43.07, 76.53 -162.93, -168.03 out-none out 11.4982 Saltbr-none 999.0 HRD-in -75.52, -44.19 73.12, -22.5 none-out-out SNCnoo out-out ActLoopNT-out 13.07 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 70.38 APE8-rot-out 40.39 APE67-dihe-out -59.74, -24.06 -87.06, 54.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K278R None None XRAY 2.89 0.197 0.233 B 466.0 336.0 10 28 18 10 [[249, 500]] 1.0 9lbg Homo sapiens STE_PAK2_HUMAN STE 1.7e-92 315.7 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 PAK2_HUMAN 9LBGA Q13177 84 522 524.0 No_ligand No_ligand Inactive DFGin 7.2462 13.2399 BLAplus -134.8, 169.74 69.29, 40.07 -99.67, -19.31 46.77, 86.97 -137.31, -170.73 out-none out 10.5922 Saltbr-none 999.0 HRD-in -69.25, -50.33 80.39, -13.72 none-out-out SNCnoo out-out ActLoopNT-out 11.5425 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 140.98 APE9-dihe-na 66.3, -179.07 APE8-dihe-in -110.51, 131.01 APE8-rot-out 171.97 APE67-dihe-out -62.5, -23.12 -83.48, 66.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.1508 APE9-dist-out 13.6894 K278R None None XRAY 2.89 0.197 0.233 A 466.0 351.0 7 28 21 7 [[249, 500]] 1.0 9lbg Homo sapiens STE_PAK2_HUMAN STE 1.7e-92 315.7 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 PAK2_HUMAN 9LBFA Q13177 86 522 524.0 No_ligand No_ligand Inactive DFGin 7.8448 13.6141 BLAplus -139.51, 166.88 74.2, 35.56 -96.67, -31.69 40.66, 100.7 -123.09, -146.04 out-out out 11.1426 Saltbr-out 7.8631 HRD-in -64.29, -56.59 86.77, -3.8 out-out-out SNCooo out-out ActLoopNT-out 11.6767 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoo APE10-dihe-na 999.0, -26.57 APE9-dihe-na 176.19, -152.47 APE8-dihe-in -84.91, 126.9 APE8-rot-in 306.43 APE67-dihe-out -58.07, -24.38 -83.02, 68.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.6347 APE9-dist-out 13.9739 D368N None None XRAY 2.62 0.199 0.222 A 479.0 351.0 8 28 20 8 [[249, 500]] 1.0 9lbf Homo sapiens STE_PAK2_HUMAN STE 4.2e-92 314.4 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 PAK2_HUMAN 9LBFB Q13177 93 522 524.0 No_ligand No_ligand Inactive DFGin 7.0308 16.6912 BLBplus -134.23, -173.46 72.48, 42.23 -141.91, 145.41 70.0, 102.23 66.59, -144.55 out-out out 11.2269 Saltbr-out 9.4629 HRD-in -79.1, -48.8 75.21, -20.52 out-out-out SNCooo out-out ActLoopNT-out 12.1265 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.12 APE8-rot-in 303.98 APE67-dihe-out -61.34, -24.51 -89.78, 56.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D368N None None XRAY 2.62 0.199 0.222 B 479.0 324.0 14 28 14 14 [[249, 500]] 1.0 9lbf Homo sapiens STE_PAK2_HUMAN STE 4.2e-92 314.4 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 PAK2_HUMAN 9D51B Q13177 231 522 524.0 A1A2Q:601 Type1 Inactive DFGin 7.4627 14.6272 BLBplus -148.89, 171.4 55.47, 51.12 -127.9, 150.94 47.62, 98.01 -123.17, -151.45 out-out out 12.7071 Saltbr-out 7.4493 HRD-in -83.39, -45.71 84.58, -20.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -102.48, -50.47 APE9-dihe-na -87.43, 155.09 APE8-dihe-in -94.3, 130.54 APE8-rot-in 291.03 APE67-dihe-out -70.68, -23.25 -91.81, 72.44 APE12-dist-out 25.9945 APE11-dist-out 22.8678 APE10-dist-out 24.1234 APE9-dist-out 13.675 D368N,T402E,P498Q,M514A None None XRAY 2.1 0.215 0.285 B 297.0 288.0 4 28 24 4 [[249, 500]] 1.0 9d51 Homo sapiens STE_PAK2_HUMAN STE 2.5e-92 314.8 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 PAK2_HUMAN 9M41A Q13177 85 520 524.0 No_ligand No_ligand Inactive DFGout 12.6843 9.0142 BBAminus -125.12, 135.19 -131.33, 83.56 -80.02, -27.51 287.94, 159.18 -71.75, -11.49 out-none out 11.1819 Saltbr-none 999.0 HRD-in -73.25, -40.38 68.65, -7.58 none-out-out SNCnoo out-out ActLoopNT-out 4.847 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -90.46, 3.09 APE9-dihe-na 125.79, -159.31 APE8-dihe-in -79.99, 115.22 APE8-rot-in 285.02 APE67-dihe-out -64.36, -25.19 -89.83, 65.97 APE12-dist-out 16.0864 APE11-dist-out 15.2925 APE10-dist-out 11.2605 APE9-dist-out 11.4899 K278R,D368N None None XRAY 3.02 0.206 0.244 A 547.0 340.0 4 28 24 4 [[249, 500]] 1.0 9m41 Homo sapiens STE_PAK2_HUMAN STE 2.1e-91 312.3 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2
PAK2 PAK2_HUMAN 9M41B Q13177 83 521 524.0 No_ligand No_ligand Inactive DFGout 14.6841 8.8721 None -119.07, 158.3 -116.1, 82.98 -67.22, 153.05 292.21, 125.16 75.02, -7.43 out-none out 12.0054 Saltbr-none 999.0 HRD-in -63.31, -45.58 68.96, -6.32 none-out-out SNCnoo out-out ActLoopNT-out 4.7448 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -164.74 APE8-dihe-in -105.73, 116.09 APE8-rot-in 316.87 APE67-dihe-out -63.1, -27.55 -87.37, 73.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.4544 K278R,D368N None None XRAY 3.02 0.206 0.244 B 547.0 342.0 7 28 21 7 [[249, 500]] 1.0 9m41 Homo sapiens STE_PAK2_HUMAN STE 2.1e-91 312.3 1.0 257.0 257.0 385 386 387 389 391 278 294 298 365 367 366 368.0 425 413 408 407 406 405 404 403 402 324 Serine/threonine-protein kinase PAK 2

STE_PAK2 (Serine/threonine-protein kinase PAK 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name