NEK_NEK7 (Serine/threonine-protein kinase Nek7)

Total number of chains: 37
Active chains: 2
Uniprot: NEK7_HUMAN
Kinase Domain Residues: 34 - 294
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 20 54.1% 9NFQC
DFGout None 7 18.9% 8SXNA
None None 5 13.5% 6S76A
DFGin BLAminus 3 8.1% AF-Q8TDX7-K1A
DFGout BBAminus 2 5.4% 8WS0B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q8TDX7-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 26 - 302 0 None None Serine/threonine-protein kinase Nek7
AF-Q8TDX7-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 26 - 302 0 None None Serine/threonine-protein kinase Nek7
9H59C 3.4 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 23 - 302 0 None None Serine/threonine-protein kinase Nek7
9NFQC 3.25 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo ADP ATPlike 20 - 300 0 None None Serine/threonine-protein kinase Nek7
2WQNA 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ADP ATPlike 21 - 300 0 None None Serine/threonine-protein kinase Nek7
8EJ4K 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
8EJ4L 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
8EJ4M 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
8EJ4N 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
8EJ4O 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
8EJ4P 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
8EJ4Q 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
8EJ4R 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
8EJ4S 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
8EJ4T 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7
2WQMA 2.1 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7
6S76B 3.38 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaino APEdist_nnoo No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7
6S76C 3.38 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7
6S73A 3.5 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaiio APEdist_nooo F9N Type1 21 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7
6S73B 3.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnoo F9N Type1 20 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7
6S73C 3.5 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 26 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7
6S75B 3.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaino APEdist_nnno F9N Type1 20 - 300 0 None None Serine/threonine-protein kinase Nek7
6S75C 3.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 22 - 300 0 None None Serine/threonine-protein kinase Nek7
8WS0B 2.12 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 19 - 299 0 None S195D Serine/threonine-protein kinase Nek7
8WS1B 2.4 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 20 - 300 0 None D161N Serine/threonine-protein kinase Nek7
5DE2A 2.78 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaooo APEdist_nnno No_ligand No_ligand 20 - 300 0 None Y97F Serine/threonine-protein kinase Nek7
6S75D 3.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 28 - 299 0 None None Serine/threonine-protein kinase Nek7
8WS0A 2.12 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 20 - 300 0 None S195D Serine/threonine-protein kinase Nek7
8SXNA 4.04 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aaioo APEdist_oiio No_ligand No_ligand 19 - 302 0 None None Serine/threonine-protein kinase Nek7
8SXNB 4.04 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aaioo APEdist_oiio No_ligand No_ligand 19 - 302 0 None None Serine/threonine-protein kinase Nek7
8WS1A 2.4 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 20 - 300 0 None D161N Serine/threonine-protein kinase Nek7
6S75A 3.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 19 - 300 0 None None Serine/threonine-protein kinase Nek7
6NPYB 3.8 Inactive None‑None none-none none-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 113 - 300 0 None L54R,V58K,P59T,K87A,A99V,S100C,E103T,D104G Serine/threonine-protein kinase Nek7
5DE2B 2.78 Inactive None‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 20 - 300 0 None Y97F Serine/threonine-protein kinase Nek7
6S73D 3.5 Inactive None‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 23 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7
6S76A 3.38 Inactive None‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 21 - 300 0 None None Serine/threonine-protein kinase Nek7
6S76D 3.38 Inactive None‑None out-none none-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 25 - 300 0 None None Serine/threonine-protein kinase Nek7

NEK_NEK7 (Serine/threonine-protein kinase Nek7)

Total number of chains: 37
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 20 54.1% 9NFQC
DFGout None 7 18.9% 8SXNA
None None 5 13.5% 6S76A
DFGin BLAminus 3 8.1% AF-Q8TDX7-K1A
DFGout BBAminus 2 5.4% 8WS0B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
NEK7_HUMAN AF-Q8TDX7-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 26 - 302 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN AF-Q8TDX7-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 26 - 302 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 9H59C 3.4 Inactive DFGin‑BLAminus out-out out-out nonTYR APEdihe_aaiio APEdist_oooo No_ligand No_ligand 23 - 302 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 9NFQC 3.25 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo ADP ATPlike 20 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 2WQNA 2.3 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ADP ATPlike 21 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8EJ4K 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8EJ4L 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8EJ4M 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8EJ4N 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8EJ4O 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8EJ4P 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8EJ4Q 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8EJ4R 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8EJ4S 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8EJ4T 3.4 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn No_ligand No_ligand 20 - 297 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 2WQMA 2.1 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S76B 3.38 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaino APEdist_nnoo No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S76C 3.38 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 20 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S73A 3.5 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaiio APEdist_nooo F9N Type1 21 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S73B 3.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnoo F9N Type1 20 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S73C 3.5 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 26 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S75B 3.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aaino APEdist_nnno F9N Type1 20 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S75C 3.3 Inactive DFGin‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 22 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8WS0B 2.12 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 19 - 299 0 None S195D Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8WS1B 2.4 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 20 - 300 0 None D161N Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 5DE2A 2.78 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaooo APEdist_nnno No_ligand No_ligand 20 - 300 0 None Y97F Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S75D 3.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 28 - 299 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8WS0A 2.12 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 20 - 300 0 None S195D Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8SXNA 4.04 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aaioo APEdist_oiio No_ligand No_ligand 19 - 302 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8SXNB 4.04 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aaioo APEdist_oiio No_ligand No_ligand 19 - 302 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 8WS1A 2.4 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 20 - 300 0 None D161N Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S75A 3.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 19 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6NPYB 3.8 Inactive None‑None none-none none-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 113 - 300 0 None L54R,V58K,P59T,K87A,A99V,S100C,E103T,D104G Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 5DE2B 2.78 Inactive None‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 20 - 300 0 None Y97F Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S73D 3.5 Inactive None‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 23 - 300 0 None L86H,Y97F,L180F Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S76A 3.38 Inactive None‑None out-none none-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 21 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK7_HUMAN 6S76D 3.38 Inactive None‑None out-none none-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 25 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens

NEK_NEK7 (Serine/threonine-protein kinase Nek7)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism