NEK_NEK7 (Serine/threonine-protein kinase Nek7)

Total number of chains: 37
Active chains: 2
Family: NEK
Uniprot: NEK7_HUMAN
Kinase Domain Residues: 34 - 294
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 20 54.1% 9NFQC
DFGout None 7 18.9% 8SXNA
None None 5 13.5% 6S76A
DFGin BLAminus 3 8.1% AF-Q8TDX7-K1A
DFGout BBAminus 2 5.4% 8WS0B

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q8TDX7-K1A 26 302 302.0 No_ligand No_ligand Active DFGin 5.668 13.157 BLAminus -141.47, -168.08 57.68, 69.72 -89.1, 15.66 300.1, 0.47 -58.86, -26.29 in-in in 9.456 Saltbr-in 2.758 HRD-in -79.82, -44.81 66.18, 3.9 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.71, 153.59 APE9-dihe-na 117.82, -176.31 APE8-dihe-in -88.44, 124.87 APE8-rot-in 302.9 APE67-dihe-in -66.41, -12.02 -48.81, -43.31 APE12-dist-in 8.914 APE11-dist-in 11.785 APE10-dist-in 5.855 APE9-dist-in 3.631 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[34, 294]] 1.0 AF-Q8TDX7-K1 NEK_NEK7_HUMAN NEK 3e-110 373.7 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
AF-Q8TDX7-K3A 26 302 302.0 No_ligand No_ligand Active DFGin 5.858 12.848 BLAminus -147.67, -167.39 52.26, 66.4 -82.56, 18.15 298.34, 0.29 -62.38, -22.17 in-in in 9.586 Saltbr-in 2.795 HRD-in -79.26, -42.39 64.54, 0.59 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.34, 159.52 APE9-dihe-na 110.25, -178.72 APE8-dihe-in -87.52, 121.97 APE8-rot-in 302.39 APE67-dihe-in -62.12, -15.11 -49.18, -42.1 APE12-dist-in 9.045 APE11-dist-in 11.95 APE10-dist-in 6.005 APE9-dist-in 3.704 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[34, 294]] 1.0 AF-Q8TDX7-K3 NEK_NEK7_HUMAN NEK 3e-110 373.7 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
9H59C 23 302 302.0 No_ligand No_ligand Inactive DFGin 6.79 11.802 BLAminus -116.76, -174.43 54.9, 63.37 -77.45, 59.63 324.77, 165.69 66.37, 10.64 out-out out 13.934 Saltbr-out 12.312 HRD-in -105.32, -50.71 68.99, -5.86 out-out-out SNCooo out-out ActLoopNT-out 9.601 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -115.09, 93.23 APE9-dihe-na 78.3, 171.65 APE8-dihe-in -107.78, 112.5 APE8-rot-in 315.55 APE67-dihe-out -69.17, -11.57 -75.76, 83.46 APE12-dist-out 19.989 APE11-dist-out 19.381 APE10-dist-out 15.401 APE9-dist-out 13.447 None None None EM 3.4 999.0 999.0 C 304 280 0 0 0 0 [[34, 294]] 1.0 9h59 NEK_NEK7_HUMAN NEK 4.3e-110 373.2 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
9NFQC 20 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.307 11.98 None -150.16, -164.53 74.32, -54.68 63.51, 118.45 304.42, 170.07 -50.32, 115.41 out-out out 14.52 Saltbr-out 10.448 HRD-in -75.46, -45.69 71.31, -4.13 out-out-out SNCooo out-out ActLoopNT-out 9.177 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -73.74, 126.83 APE9-dihe-na 80.61, 29.64 APE8-dihe-in -127.17, 154.0 APE8-rot-out 66.52 APE67-dihe-out -56.05, -43.39 -68.04, 167.92 APE12-dist-out 15.571 APE11-dist-out 14.531 APE10-dist-out 11.825 APE9-dist-out 8.487 None None None XRAY 3.25 0.214 0.261 C 304 281 0 0 0 0 [[34, 294]] 1.0 9nfq NEK_NEK7_HUMAN NEK 4.3e-110 373.2 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
2WQNA 21 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.366 14.509 None -71.0, 173.16 -64.84, 135.91 -62.15, 999.0 305.22, 52.49 999.0, 999.0 out-out out 14.034 Saltbr-out 12.947 HRD-in -74.75, -50.15 86.13, -19.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 77.46 APE8-rot-none 999.0 APE67-dihe-out -63.25, -48.51 -54.4, 143.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.192 0.221 A 310 259 21 0 0 18 [[34, 294]] 1.0 2wqn NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8EJ4K 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.726 12.702 None -76.42, 178.47 -68.48, 131.61 -71.46, 136.2 73.57, 100.38 -72.87, 999.0 out-none out 15.646 Saltbr-none 999.0 HRD-out -85.33, 115.72 -60.76, -44.72 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.68 APE8-rot-in 320.17 APE67-dihe-out -62.46, -41.14 -76.28, 170.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 K 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8EJ4L 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.728 12.701 None -76.4, 178.58 -68.63, 131.64 -71.57, 136.19 73.61, 100.3 -72.85, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.34, 115.69 -60.77, -44.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.69 APE8-rot-in 320.25 APE67-dihe-out -62.33, -41.29 -76.38, 170.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 L 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8EJ4M 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.727 12.703 None -76.4, 178.51 -68.6, 131.68 -71.51, 136.18 73.59, 100.26 -72.74, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.42, 115.71 -60.74, -44.77 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.73 APE8-rot-in 320.25 APE67-dihe-out -62.39, -41.25 -76.39, 170.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 M 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8EJ4N 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.727 12.701 None -76.43, 178.48 -68.52, 131.6 -71.44, 136.14 73.59, 100.37 -72.79, 999.0 out-none out 15.646 Saltbr-none 999.0 HRD-out -85.34, 115.77 -60.86, -44.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.75 APE8-rot-in 320.35 APE67-dihe-out -62.31, -41.37 -76.45, 170.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 N 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8EJ4O 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.727 12.702 None -76.34, 178.47 -68.49, 131.55 -71.34, 136.17 73.67, 100.39 -72.81, 999.0 out-none out 15.644 Saltbr-none 999.0 HRD-out -85.31, 115.68 -60.76, -44.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.77 APE8-rot-in 320.21 APE67-dihe-out -62.36, -41.36 -76.32, 170.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 O 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8EJ4P 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.729 12.702 None -76.31, 178.45 -68.55, 131.56 -71.36, 136.2 73.73, 100.23 -72.8, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.31, 115.58 -60.59, -44.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.71 APE8-rot-in 320.25 APE67-dihe-out -62.34, -41.31 -76.37, 170.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 P 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8EJ4Q 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.728 12.701 None -76.49, 178.43 -68.49, 131.55 -71.33, 136.21 73.64, 100.4 -72.85, 999.0 out-none out 15.644 Saltbr-none 999.0 HRD-out -85.44, 115.71 -60.71, -44.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.79 APE8-rot-in 320.09 APE67-dihe-out -62.41, -41.17 -76.39, 170.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 Q 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8EJ4R 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.728 12.701 None -76.4, 178.44 -68.5, 131.69 -71.51, 136.22 73.62, 100.38 -72.88, 999.0 out-none out 15.643 Saltbr-none 999.0 HRD-out -85.44, 115.7 -60.7, -44.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.78 APE8-rot-in 320.16 APE67-dihe-out -62.38, -41.22 -76.37, 170.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 R 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8EJ4S 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.729 12.704 None -76.31, 178.32 -68.42, 131.55 -71.49, 136.23 73.63, 100.27 -72.77, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.28, 115.69 -60.57, -45.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.74 APE8-rot-in 320.25 APE67-dihe-out -62.31, -41.25 -76.38, 170.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 S 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8EJ4T 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.727 12.702 None -76.48, 178.46 -68.52, 131.53 -71.34, 136.16 73.66, 100.37 -72.83, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.37, 115.71 -60.75, -44.77 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.75 APE8-rot-in 320.16 APE67-dihe-out -62.36, -41.21 -76.33, 170.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 T 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
2WQMA 20 300 302.0 No_ligand No_ligand Inactive DFGin 7.346 13.778 None -83.18, 179.58 -74.59, 155.64 -97.08, 999.0 302.48, 61.21 999.0, 999.0 out-out out 13.957 Saltbr-out 15.242 HRD-in -76.69, -51.78 83.33, -13.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 71.1 APE8-rot-none 999.0 APE67-dihe-out -59.91, -51.02 -52.53, 142.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.175 0.215 A 310 258 23 0 0 18 [[34, 294]] 1.0 2wqm NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S76B 20 300 302.0 No_ligand No_ligand Inactive DFGin 10.751 13.109 None -166.45, -175.9 66.54, -60.08 52.94, 60.47 203.88, 147.31 -68.33, 173.75 out-none out 14.948 Saltbr-none 999.0 HRD-in -70.18, -57.7 76.2, 16.82 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnoo APE10-dihe-na 999.0, 48.62 APE9-dihe-na -59.14, -24.85 APE8-dihe-in -73.32, 170.94 APE8-rot-none 999.0 APE67-dihe-out -57.66, -44.72 -55.45, 165.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.637 APE9-dist-out 12.992 None None None XRAY 3.38 0.263 0.286 B 310 267 14 0 0 14 [[34, 294]] 1.0 6s76 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S76C 20 300 302.0 No_ligand No_ligand Inactive DFGin 8.583 12.769 None -80.45, -160.94 -77.29, 134.54 -77.74, 135.51 80.77, 94.75 -93.77, 999.0 out-none out 15.943 Saltbr-none 999.0 HRD-out -62.26, 96.66 -62.75, -12.92 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.78 APE8-rot-out 166.56 APE67-dihe-out -62.39, -38.88 -77.41, 171.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.38 0.263 0.286 C 310 264 17 0 0 17 [[34, 294]] 1.0 6s76 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S73A 21 300 302.0 F9N:401 Type1 Inactive DFGin 5.053 16.363 None -130.23, -159.39 -58.38, 166.65 -79.47, 179.09 272.7, 63.92 -73.82, 153.18 out-none out 12.519 Saltbr-none 999.0 HRD-in -67.13, -43.16 71.04, 8.92 none-out-out SNCnoo out-out ActLoopNT-out 13.589 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -68.95, 142.63 APE9-dihe-na -130.01, 150.44 APE8-dihe-in -121.46, 109.43 APE8-rot-in 306.53 APE67-dihe-out -37.47, -40.83 -62.79, 124.97 APE12-dist-none 999.0 APE11-dist-out 15.445 APE10-dist-out 16.342 APE9-dist-out 13.34 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 A 310 269 11 0 0 11 [[34, 294]] 1.0 6s73 NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S73B 20 300 302.0 F9N:401 Type1 Inactive DFGin 4.081 13.935 None -178.99, -162.49 51.26, 73.22 -85.88, 62.38 41.39, 63.66 -85.37, 89.52 out-out out 12.585 Saltbr-out 10.366 HRD-in -66.25, -45.52 76.82, -13.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 162.68 APE9-dihe-na -69.13, -43.33 APE8-dihe-in -76.26, 166.14 APE8-rot-out 72.57 APE67-dihe-out -54.8, -43.78 -51.06, 164.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.705 APE9-dist-out 14.412 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 B 310 268 13 0 0 13 [[34, 294]] 1.0 6s73 NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S73C 26 300 302.0 F9N:401 Type1 Inactive DFGin 5.139 15.712 None 175.05, 74.28 -158.3, 138.44 -107.91, 105.5 333.64, 111.47 -61.5, -31.06 out-none out 13.739 Saltbr-none 999.0 HRD-in -76.21, -36.25 71.18, -6.76 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.69 APE8-rot-in 301.01 APE67-dihe-out -51.09, -38.47 -89.97, 146.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 C 310 259 16 0 0 16 [[34, 294]] 1.0 6s73 NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S75B 20 300 302.0 F9N:401 Type1 Inactive DFGin 7.413 13.763 None -73.24, -152.21 -93.79, 137.64 -65.56, 124.67 301.05, 76.91 -140.58, 68.85 out-none out 15.568 Saltbr-none 999.0 HRD-out -97.46, 106.21 -102.94, 24.07 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 46.75 APE8-dihe-in -82.12, 132.19 APE8-rot-none 999.0 APE67-dihe-out 55.67, -108.68 -80.05, 59.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.817 None None None XRAY 3.3 0.263 0.317 B 310 267 14 0 0 14 [[34, 294]] 1.0 6s75 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S75C 22 300 302.0 F9N:401 Type1 Inactive DFGin 7.903 12.994 None -83.1, -140.31 -120.94, 14.53 61.24, -160.83 311.61, 103.49 -179.49, 170.79 out-none out 16.263 Saltbr-none 999.0 HRD-in -77.1, -41.1 71.89, -12.02 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 68.43 APE8-rot-in 309.88 APE67-dihe-out -56.73, -49.48 -77.1, 161.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.263 0.317 C 310 263 16 0 0 16 [[34, 294]] 1.0 6s75 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8WS0B 19 299 302.0 No_ligand No_ligand Inactive DFGout 11.829 7.315 BBAminus -133.8, -177.99 -130.04, 2.82 -100.28, -18.42 303.31, 171.37 65.02, 27.85 out-out out 12.745 Saltbr-out 11.072 HRD-in -83.35, -48.76 86.54, -17.05 out-out-out SNCooo out-out ActLoopNT-out 21.046 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 100.79 APE8-rot-none 999.0 APE67-dihe-out -57.82, -46.82 -62.82, 161.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S195D None None XRAY 2.12 0.194 0.242 B 310 270 11 0 0 11 [[34, 294]] 1.0 8ws0 NEK_NEK7_HUMAN NEK 2.2e-109 370.9 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8WS1B 20 300 302.0 No_ligand No_ligand Inactive DFGout 12.737 7.123 BBAminus -122.1, -178.22 -130.65, 17.02 -109.65, -29.8 244.31, 55.9 74.43, 25.28 out-out out 12.552 Saltbr-out 9.733 HRD-in -73.6, -51.3 80.92, -17.68 out-out-out SNCooo out-out ActLoopNT-out 20.913 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.66 APE8-rot-none 999.0 APE67-dihe-out -63.68, -58.52 -59.64, 162.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D161N None None XRAY 2.4 0.182 0.238 B 310 270 11 0 0 11 [[34, 294]] 1.0 8ws1 NEK_NEK7_HUMAN NEK 4.7e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
5DE2A 20 300 302.0 No_ligand No_ligand Inactive DFGout 15.956 9.975 None -128.71, -164.31 -159.55, 105.35 -134.06, 13.95 44.91, 64.73 -53.86, 999.0 out-out out 12.455 Saltbr-out 10.152 HRD-in -75.93, -50.83 83.71, -4.84 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na -106.4, -83.92 APE9-dihe-na 54.75, 40.12 APE8-dihe-out -123.55, -175.62 APE8-rot-out 53.04 APE67-dihe-out -60.87, -48.39 -64.23, 167.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.583 Y97F None None XRAY 2.78 0.208 0.254 A 310 267 14 0 0 14 [[34, 294]] 1.0 5de2 NEK_NEK7_HUMAN NEK 1.1e-109 371.9 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S75D 28 299 302.0 No_ligand No_ligand Inactive DFGout 14.999 7.367 None -166.46, 158.29 -82.74, 165.99 -157.73, 999.0 194.93, 158.62 999.0, 999.0 out-none out 14.649 Saltbr-none 999.0 HRD-in -81.95, -31.31 73.93, -11.28 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.27 APE8-rot-out 187.12 APE67-dihe-out -53.24, -37.09 -86.66, 129.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.263 0.317 D 310 254 18 0 0 18 [[34, 294]] 1.0 6s75 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8WS0A 20 300 302.0 No_ligand No_ligand Inactive DFGout 14.793 8.417 None -126.74, -156.49 -164.76, 70.94 -80.34, 105.46 253.24, 45.67 122.99, -12.21 out-out out 12.608 Saltbr-out 12.087 HRD-in -80.21, -59.73 88.07, -8.86 out-out-none SNCoon out-none ActLoopNT-out 7.602 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -50.05, -47.07 999.0, 174.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S195D None None XRAY 2.12 0.194 0.242 A 310 267 14 0 0 14 [[34, 294]] 1.0 8ws0 NEK_NEK7_HUMAN NEK 2.2e-109 370.9 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8SXNA 19 302 302.0 No_ligand No_ligand Inactive DFGout 13.26 7.051 None -97.04, -178.51 -134.2, 15.98 -53.39, -53.98 294.4, 175.32 46.87, -137.52 out-na out 12.289 Saltbr-na 999.0 HRD-in -84.09, -52.6 74.42, 0.89 na-out-out SNCaoo out-out ActLoopNT-out 10.403 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oiio APE10-dihe-na -99.9, 104.59 APE9-dihe-na 131.25, 169.02 APE8-dihe-in -126.44, 85.78 APE8-rot-out 56.84 APE67-dihe-out -117.7, -17.17 -76.53, 52.47 APE12-dist-out 14.424 APE11-dist-in 11.557 APE10-dist-in 6.973 APE9-dist-out 8.493 None None None EM 4.04 999.0 999.0 A 302 284 0 0 0 0 [[34, 294]] 1.0 8sxn NEK_NEK7_HUMAN NEK 4e-108 366.7 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8SXNB 19 302 302.0 No_ligand No_ligand Inactive DFGout 13.282 7.021 None -98.02, -178.13 -134.86, 16.11 -53.29, -53.66 295.46, 175.72 47.19, -137.89 out-na out 12.358 Saltbr-na 999.0 HRD-in -85.26, -51.29 73.01, 1.84 na-out-out SNCaoo out-out ActLoopNT-out 10.451 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oiio APE10-dihe-na -102.12, 104.08 APE9-dihe-na 130.75, 169.65 APE8-dihe-in -126.36, 84.87 APE8-rot-out 56.76 APE67-dihe-out -116.25, -19.71 -76.43, 51.64 APE12-dist-out 14.399 APE11-dist-in 11.59 APE10-dist-in 7.03 APE9-dist-out 8.572 None None None EM 4.04 999.0 999.0 B 302 284 0 0 0 0 [[34, 294]] 1.0 8sxn NEK_NEK7_HUMAN NEK 4e-108 366.7 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
8WS1A 20 300 302.0 No_ligand No_ligand Inactive DFGout 15.643 9.693 None -122.39, -160.29 -158.98, 87.8 -69.33, 110.52 278.14, 2.64 80.33, 43.56 out-out out 12.567 Saltbr-out 11.127 HRD-in -82.09, -55.82 81.38, -4.82 out-out-none SNCoon out-none ActLoopNT-out 7.934 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -52.44, -53.29 999.0, 167.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D161N None None XRAY 2.4 0.182 0.238 A 310 268 13 0 0 13 [[34, 294]] 1.0 8ws1 NEK_NEK7_HUMAN NEK 4.7e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S75A 19 300 302.0 F9N:401 Type1 Inactive DFGout 11.113 9.298 None -95.87, 117.08 -81.73, 113.39 -121.19, -164.54 277.36, 113.08 169.85, 169.25 out-none out 13.693 Saltbr-none 999.0 HRD-out -64.39, 111.72 -90.05, -17.06 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.84 APE8-rot-in 294.52 APE67-dihe-out -50.57, -58.17 -66.53, 143.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.263 0.317 A 310 267 15 0 0 15 [[34, 294]] 1.0 6s75 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6NPYB 113 300 302.0 No_ligand No_ligand Inactive None 999.0 999.0 None -70.39, 159.94 -79.69, -166.49 -68.35, 999.0 292.03, 88.65 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -119.72, -48.43 68.42, -5.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 107.72 APE8-rot-none 999.0 APE67-dihe-out -70.9, -51.67 -73.37, 174.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L54R,V58K,P59T,K87A,A99V,S100C,E103T,D104G None None EM 3.8 999.0 999.0 B 279 188 100 0 0 18 [[34, 294]] 1.0 6npy NEK_NEK7_HUMAN NEK 7e-109 369.2 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
5DE2B 20 300 302.0 No_ligand No_ligand Inactive None 999.0 999.0 None -122.26, 169.15 -110.33, -36.5 -85.96, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.616 Saltbr-out 10.406 HRD-in -69.6, -49.19 79.72, -12.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -73.41, -54.18 999.0, 123.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 Y97F None None XRAY 2.78 0.208 0.254 B 310 262 19 0 0 19 [[34, 294]] 1.0 5de2 NEK_NEK7_HUMAN NEK 1.1e-109 371.9 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S73D 23 300 302.0 No_ligand No_ligand Inactive None 999.0 999.0 None -142.5, 117.16 -74.81, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.907 Saltbr-none 999.0 HRD-in -71.14, -32.97 72.66, -48.89 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.43 APE8-rot-out 166.85 APE67-dihe-out -54.39, -32.76 -76.19, 149.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 D 310 259 19 0 0 19 [[34, 294]] 1.0 6s73 NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S76A 21 300 302.0 No_ligand No_ligand Inactive None 999.0 999.0 None -80.02, -140.08 -107.31, -166.49 -126.34, -163.23 999.0, 999.0 -146.75, 999.0 out-none out 13.145 Saltbr-none 999.0 HRD-in -63.77, -26.33 75.45, -37.94 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -104.41, 111.55 APE9-dihe-na -64.79, 141.94 APE8-dihe-in -133.77, 121.5 APE8-rot-in 279.99 APE67-dihe-out -60.92, -48.93 -72.08, 150.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.77 None None None XRAY 3.38 0.263 0.286 A 310 266 14 0 0 14 [[34, 294]] 1.0 6s76 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
6S76D 25 300 302.0 No_ligand No_ligand Inactive None 999.0 999.0 None 170.47, 120.54 -53.25, 141.84 -130.46, 999.0 999.0, 999.0 999.0, 999.0 out-none out 16.766 Saltbr-none 999.0 HRD-out -82.4, 102.3 -63.51, -66.82 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 107.43 APE8-rot-none 999.0 APE67-dihe-out -56.39, -29.32 -67.06, 85.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.38 0.263 0.286 D 310 258 18 0 0 18 [[34, 294]] 1.0 6s76 NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7

NEK_NEK7 (Serine/threonine-protein kinase Nek7)

Total number of chains: 37
Active chains: 2
Family: NEK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 20 54.1% 9NFQC
DFGout None 7 18.9% 8SXNA
None None 5 13.5% 6S76A
DFGin BLAminus 3 8.1% AF-Q8TDX7-K1A
DFGout BBAminus 2 5.4% 8WS0B

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
NEK7_HUMAN AF-Q8TDX7-K1A Q8TDX7 26 302 302.0 No_ligand No_ligand Active DFGin 5.668 13.157 BLAminus -141.47, -168.08 57.68, 69.72 -89.1, 15.66 300.1, 0.47 -58.86, -26.29 in-in in 9.456 Saltbr-in 2.758 HRD-in -79.82, -44.81 66.18, 3.9 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.71, 153.59 APE9-dihe-na 117.82, -176.31 APE8-dihe-in -88.44, 124.87 APE8-rot-in 302.9 APE67-dihe-in -66.41, -12.02 -48.81, -43.31 APE12-dist-in 8.914 APE11-dist-in 11.785 APE10-dist-in 5.855 APE9-dist-in 3.631 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[34, 294]] 1.0 AF-Q8TDX7-K1 Homo sapiens NEK_NEK7_HUMAN NEK 3e-110 373.7 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN AF-Q8TDX7-K3A Q8TDX7 26 302 302.0 No_ligand No_ligand Active DFGin 5.858 12.848 BLAminus -147.67, -167.39 52.26, 66.4 -82.56, 18.15 298.34, 0.29 -62.38, -22.17 in-in in 9.586 Saltbr-in 2.795 HRD-in -79.26, -42.39 64.54, 0.59 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.34, 159.52 APE9-dihe-na 110.25, -178.72 APE8-dihe-in -87.52, 121.97 APE8-rot-in 302.39 APE67-dihe-in -62.12, -15.11 -49.18, -42.1 APE12-dist-in 9.045 APE11-dist-in 11.95 APE10-dist-in 6.005 APE9-dist-in 3.704 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[34, 294]] 1.0 AF-Q8TDX7-K3 Homo sapiens NEK_NEK7_HUMAN NEK 3e-110 373.7 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 9H59C Q8TDX7 23 302 302.0 No_ligand No_ligand Inactive DFGin 6.79 11.802 BLAminus -116.76, -174.43 54.9, 63.37 -77.45, 59.63 324.77, 165.69 66.37, 10.64 out-out out 13.934 Saltbr-out 12.312 HRD-in -105.32, -50.71 68.99, -5.86 out-out-out SNCooo out-out ActLoopNT-out 9.601 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -115.09, 93.23 APE9-dihe-na 78.3, 171.65 APE8-dihe-in -107.78, 112.5 APE8-rot-in 315.55 APE67-dihe-out -69.17, -11.57 -75.76, 83.46 APE12-dist-out 19.989 APE11-dist-out 19.381 APE10-dist-out 15.401 APE9-dist-out 13.447 None None None EM 3.4 999.0 999.0 C 304 280 0 0 0 0 [[34, 294]] 1.0 9h59 Homo sapiens NEK_NEK7_HUMAN NEK 4.3e-110 373.2 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 9NFQC Q8TDX7 20 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.307 11.98 None -150.16, -164.53 74.32, -54.68 63.51, 118.45 304.42, 170.07 -50.32, 115.41 out-out out 14.52 Saltbr-out 10.448 HRD-in -75.46, -45.69 71.31, -4.13 out-out-out SNCooo out-out ActLoopNT-out 9.177 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -73.74, 126.83 APE9-dihe-na 80.61, 29.64 APE8-dihe-in -127.17, 154.0 APE8-rot-out 66.52 APE67-dihe-out -56.05, -43.39 -68.04, 167.92 APE12-dist-out 15.571 APE11-dist-out 14.531 APE10-dist-out 11.825 APE9-dist-out 8.487 None None None XRAY 3.25 0.214 0.261 C 304 281 0 0 0 0 [[34, 294]] 1.0 9nfq Homo sapiens NEK_NEK7_HUMAN NEK 4.3e-110 373.2 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 2WQNA Q8TDX7 21 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.366 14.509 None -71.0, 173.16 -64.84, 135.91 -62.15, 999.0 305.22, 52.49 999.0, 999.0 out-out out 14.034 Saltbr-out 12.947 HRD-in -74.75, -50.15 86.13, -19.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 77.46 APE8-rot-none 999.0 APE67-dihe-out -63.25, -48.51 -54.4, 143.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.192 0.221 A 310 259 21 0 0 18 [[34, 294]] 1.0 2wqn Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8EJ4K Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.726 12.702 None -76.42, 178.47 -68.48, 131.61 -71.46, 136.2 73.57, 100.38 -72.87, 999.0 out-none out 15.646 Saltbr-none 999.0 HRD-out -85.33, 115.72 -60.76, -44.72 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.68 APE8-rot-in 320.17 APE67-dihe-out -62.46, -41.14 -76.28, 170.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 K 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8EJ4L Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.728 12.701 None -76.4, 178.58 -68.63, 131.64 -71.57, 136.19 73.61, 100.3 -72.85, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.34, 115.69 -60.77, -44.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.69 APE8-rot-in 320.25 APE67-dihe-out -62.33, -41.29 -76.38, 170.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 L 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8EJ4M Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.727 12.703 None -76.4, 178.51 -68.6, 131.68 -71.51, 136.18 73.59, 100.26 -72.74, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.42, 115.71 -60.74, -44.77 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.73 APE8-rot-in 320.25 APE67-dihe-out -62.39, -41.25 -76.39, 170.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 M 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8EJ4N Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.727 12.701 None -76.43, 178.48 -68.52, 131.6 -71.44, 136.14 73.59, 100.37 -72.79, 999.0 out-none out 15.646 Saltbr-none 999.0 HRD-out -85.34, 115.77 -60.86, -44.78 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.75 APE8-rot-in 320.35 APE67-dihe-out -62.31, -41.37 -76.45, 170.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 N 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8EJ4O Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.727 12.702 None -76.34, 178.47 -68.49, 131.55 -71.34, 136.17 73.67, 100.39 -72.81, 999.0 out-none out 15.644 Saltbr-none 999.0 HRD-out -85.31, 115.68 -60.76, -44.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.77 APE8-rot-in 320.21 APE67-dihe-out -62.36, -41.36 -76.32, 170.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 O 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8EJ4P Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.729 12.702 None -76.31, 178.45 -68.55, 131.56 -71.36, 136.2 73.73, 100.23 -72.8, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.31, 115.58 -60.59, -44.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.71 APE8-rot-in 320.25 APE67-dihe-out -62.34, -41.31 -76.37, 170.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 P 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8EJ4Q Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.728 12.701 None -76.49, 178.43 -68.49, 131.55 -71.33, 136.21 73.64, 100.4 -72.85, 999.0 out-none out 15.644 Saltbr-none 999.0 HRD-out -85.44, 115.71 -60.71, -44.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.79 APE8-rot-in 320.09 APE67-dihe-out -62.41, -41.17 -76.39, 170.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 Q 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8EJ4R Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.728 12.701 None -76.4, 178.44 -68.5, 131.69 -71.51, 136.22 73.62, 100.38 -72.88, 999.0 out-none out 15.643 Saltbr-none 999.0 HRD-out -85.44, 115.7 -60.7, -44.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.78 APE8-rot-in 320.16 APE67-dihe-out -62.38, -41.22 -76.37, 170.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 R 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8EJ4S Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.729 12.704 None -76.31, 178.32 -68.42, 131.55 -71.49, 136.23 73.63, 100.27 -72.77, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.28, 115.69 -60.57, -45.0 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.74 APE8-rot-in 320.25 APE67-dihe-out -62.31, -41.25 -76.38, 170.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 S 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8EJ4T Q8TDX7 20 297 302.0 No_ligand No_ligand Inactive DFGin 8.727 12.702 None -76.48, 178.46 -68.52, 131.53 -71.34, 136.16 73.66, 100.37 -72.83, 999.0 out-none out 15.645 Saltbr-none 999.0 HRD-out -85.37, 115.71 -60.75, -44.77 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.75 APE8-rot-in 320.16 APE67-dihe-out -62.36, -41.21 -76.33, 170.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 T 278 261 17 0 0 17 [[34, 294]] 1.0 8ej4 Homo sapiens NEK_NEK7_HUMAN NEK 3.1e-110 373.6 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 2WQMA Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGin 7.346 13.778 None -83.18, 179.58 -74.59, 155.64 -97.08, 999.0 302.48, 61.21 999.0, 999.0 out-out out 13.957 Saltbr-out 15.242 HRD-in -76.69, -51.78 83.33, -13.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 71.1 APE8-rot-none 999.0 APE67-dihe-out -59.91, -51.02 -52.53, 142.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.175 0.215 A 310 258 23 0 0 18 [[34, 294]] 1.0 2wqm Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S76B Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGin 10.751 13.109 None -166.45, -175.9 66.54, -60.08 52.94, 60.47 203.88, 147.31 -68.33, 173.75 out-none out 14.948 Saltbr-none 999.0 HRD-in -70.18, -57.7 76.2, 16.82 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnoo APE10-dihe-na 999.0, 48.62 APE9-dihe-na -59.14, -24.85 APE8-dihe-in -73.32, 170.94 APE8-rot-none 999.0 APE67-dihe-out -57.66, -44.72 -55.45, 165.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.637 APE9-dist-out 12.992 None None None XRAY 3.38 0.263 0.286 B 310 267 14 0 0 14 [[34, 294]] 1.0 6s76 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S76C Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGin 8.583 12.769 None -80.45, -160.94 -77.29, 134.54 -77.74, 135.51 80.77, 94.75 -93.77, 999.0 out-none out 15.943 Saltbr-none 999.0 HRD-out -62.26, 96.66 -62.75, -12.92 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.78 APE8-rot-out 166.56 APE67-dihe-out -62.39, -38.88 -77.41, 171.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.38 0.263 0.286 C 310 264 17 0 0 17 [[34, 294]] 1.0 6s76 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S73A Q8TDX7 21 300 302.0 F9N:401 Type1 Inactive DFGin 5.053 16.363 None -130.23, -159.39 -58.38, 166.65 -79.47, 179.09 272.7, 63.92 -73.82, 153.18 out-none out 12.519 Saltbr-none 999.0 HRD-in -67.13, -43.16 71.04, 8.92 none-out-out SNCnoo out-out ActLoopNT-out 13.589 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nooo APE10-dihe-na -68.95, 142.63 APE9-dihe-na -130.01, 150.44 APE8-dihe-in -121.46, 109.43 APE8-rot-in 306.53 APE67-dihe-out -37.47, -40.83 -62.79, 124.97 APE12-dist-none 999.0 APE11-dist-out 15.445 APE10-dist-out 16.342 APE9-dist-out 13.34 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 A 310 269 11 0 0 11 [[34, 294]] 1.0 6s73 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S73B Q8TDX7 20 300 302.0 F9N:401 Type1 Inactive DFGin 4.081 13.935 None -178.99, -162.49 51.26, 73.22 -85.88, 62.38 41.39, 63.66 -85.37, 89.52 out-out out 12.585 Saltbr-out 10.366 HRD-in -66.25, -45.52 76.82, -13.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 162.68 APE9-dihe-na -69.13, -43.33 APE8-dihe-in -76.26, 166.14 APE8-rot-out 72.57 APE67-dihe-out -54.8, -43.78 -51.06, 164.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.705 APE9-dist-out 14.412 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 B 310 268 13 0 0 13 [[34, 294]] 1.0 6s73 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S73C Q8TDX7 26 300 302.0 F9N:401 Type1 Inactive DFGin 5.139 15.712 None 175.05, 74.28 -158.3, 138.44 -107.91, 105.5 333.64, 111.47 -61.5, -31.06 out-none out 13.739 Saltbr-none 999.0 HRD-in -76.21, -36.25 71.18, -6.76 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.69 APE8-rot-in 301.01 APE67-dihe-out -51.09, -38.47 -89.97, 146.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 C 310 259 16 0 0 16 [[34, 294]] 1.0 6s73 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S75B Q8TDX7 20 300 302.0 F9N:401 Type1 Inactive DFGin 7.413 13.763 None -73.24, -152.21 -93.79, 137.64 -65.56, 124.67 301.05, 76.91 -140.58, 68.85 out-none out 15.568 Saltbr-none 999.0 HRD-out -97.46, 106.21 -102.94, 24.07 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 46.75 APE8-dihe-in -82.12, 132.19 APE8-rot-none 999.0 APE67-dihe-out 55.67, -108.68 -80.05, 59.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.817 None None None XRAY 3.3 0.263 0.317 B 310 267 14 0 0 14 [[34, 294]] 1.0 6s75 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S75C Q8TDX7 22 300 302.0 F9N:401 Type1 Inactive DFGin 7.903 12.994 None -83.1, -140.31 -120.94, 14.53 61.24, -160.83 311.61, 103.49 -179.49, 170.79 out-none out 16.263 Saltbr-none 999.0 HRD-in -77.1, -41.1 71.89, -12.02 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 68.43 APE8-rot-in 309.88 APE67-dihe-out -56.73, -49.48 -77.1, 161.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.263 0.317 C 310 263 16 0 0 16 [[34, 294]] 1.0 6s75 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8WS0B Q8TDX7 19 299 302.0 No_ligand No_ligand Inactive DFGout 11.829 7.315 BBAminus -133.8, -177.99 -130.04, 2.82 -100.28, -18.42 303.31, 171.37 65.02, 27.85 out-out out 12.745 Saltbr-out 11.072 HRD-in -83.35, -48.76 86.54, -17.05 out-out-out SNCooo out-out ActLoopNT-out 21.046 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 100.79 APE8-rot-none 999.0 APE67-dihe-out -57.82, -46.82 -62.82, 161.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S195D None None XRAY 2.12 0.194 0.242 B 310 270 11 0 0 11 [[34, 294]] 1.0 8ws0 Homo sapiens NEK_NEK7_HUMAN NEK 2.2e-109 370.9 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8WS1B Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGout 12.737 7.123 BBAminus -122.1, -178.22 -130.65, 17.02 -109.65, -29.8 244.31, 55.9 74.43, 25.28 out-out out 12.552 Saltbr-out 9.733 HRD-in -73.6, -51.3 80.92, -17.68 out-out-out SNCooo out-out ActLoopNT-out 20.913 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.66 APE8-rot-none 999.0 APE67-dihe-out -63.68, -58.52 -59.64, 162.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D161N None None XRAY 2.4 0.182 0.238 B 310 270 11 0 0 11 [[34, 294]] 1.0 8ws1 Homo sapiens NEK_NEK7_HUMAN NEK 4.7e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 5DE2A Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGout 15.956 9.975 None -128.71, -164.31 -159.55, 105.35 -134.06, 13.95 44.91, 64.73 -53.86, 999.0 out-out out 12.455 Saltbr-out 10.152 HRD-in -75.93, -50.83 83.71, -4.84 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na -106.4, -83.92 APE9-dihe-na 54.75, 40.12 APE8-dihe-out -123.55, -175.62 APE8-rot-out 53.04 APE67-dihe-out -60.87, -48.39 -64.23, 167.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.583 Y97F None None XRAY 2.78 0.208 0.254 A 310 267 14 0 0 14 [[34, 294]] 1.0 5de2 Homo sapiens NEK_NEK7_HUMAN NEK 1.1e-109 371.9 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S75D Q8TDX7 28 299 302.0 No_ligand No_ligand Inactive DFGout 14.999 7.367 None -166.46, 158.29 -82.74, 165.99 -157.73, 999.0 194.93, 158.62 999.0, 999.0 out-none out 14.649 Saltbr-none 999.0 HRD-in -81.95, -31.31 73.93, -11.28 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.27 APE8-rot-out 187.12 APE67-dihe-out -53.24, -37.09 -86.66, 129.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.263 0.317 D 310 254 18 0 0 18 [[34, 294]] 1.0 6s75 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8WS0A Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGout 14.793 8.417 None -126.74, -156.49 -164.76, 70.94 -80.34, 105.46 253.24, 45.67 122.99, -12.21 out-out out 12.608 Saltbr-out 12.087 HRD-in -80.21, -59.73 88.07, -8.86 out-out-none SNCoon out-none ActLoopNT-out 7.602 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -50.05, -47.07 999.0, 174.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S195D None None XRAY 2.12 0.194 0.242 A 310 267 14 0 0 14 [[34, 294]] 1.0 8ws0 Homo sapiens NEK_NEK7_HUMAN NEK 2.2e-109 370.9 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8SXNA Q8TDX7 19 302 302.0 No_ligand No_ligand Inactive DFGout 13.26 7.051 None -97.04, -178.51 -134.2, 15.98 -53.39, -53.98 294.4, 175.32 46.87, -137.52 out-na out 12.289 Saltbr-na 999.0 HRD-in -84.09, -52.6 74.42, 0.89 na-out-out SNCaoo out-out ActLoopNT-out 10.403 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oiio APE10-dihe-na -99.9, 104.59 APE9-dihe-na 131.25, 169.02 APE8-dihe-in -126.44, 85.78 APE8-rot-out 56.84 APE67-dihe-out -117.7, -17.17 -76.53, 52.47 APE12-dist-out 14.424 APE11-dist-in 11.557 APE10-dist-in 6.973 APE9-dist-out 8.493 None None None EM 4.04 999.0 999.0 A 302 284 0 0 0 0 [[34, 294]] 1.0 8sxn Homo sapiens NEK_NEK7_HUMAN NEK 4e-108 366.7 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8SXNB Q8TDX7 19 302 302.0 No_ligand No_ligand Inactive DFGout 13.282 7.021 None -98.02, -178.13 -134.86, 16.11 -53.29, -53.66 295.46, 175.72 47.19, -137.89 out-na out 12.358 Saltbr-na 999.0 HRD-in -85.26, -51.29 73.01, 1.84 na-out-out SNCaoo out-out ActLoopNT-out 10.451 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oiio APE10-dihe-na -102.12, 104.08 APE9-dihe-na 130.75, 169.65 APE8-dihe-in -126.36, 84.87 APE8-rot-out 56.76 APE67-dihe-out -116.25, -19.71 -76.43, 51.64 APE12-dist-out 14.399 APE11-dist-in 11.59 APE10-dist-in 7.03 APE9-dist-out 8.572 None None None EM 4.04 999.0 999.0 B 302 284 0 0 0 0 [[34, 294]] 1.0 8sxn Homo sapiens NEK_NEK7_HUMAN NEK 4e-108 366.7 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 8WS1A Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive DFGout 15.643 9.693 None -122.39, -160.29 -158.98, 87.8 -69.33, 110.52 278.14, 2.64 80.33, 43.56 out-out out 12.567 Saltbr-out 11.127 HRD-in -82.09, -55.82 81.38, -4.82 out-out-none SNCoon out-none ActLoopNT-out 7.934 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -52.44, -53.29 999.0, 167.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D161N None None XRAY 2.4 0.182 0.238 A 310 268 13 0 0 13 [[34, 294]] 1.0 8ws1 Homo sapiens NEK_NEK7_HUMAN NEK 4.7e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S75A Q8TDX7 19 300 302.0 F9N:401 Type1 Inactive DFGout 11.113 9.298 None -95.87, 117.08 -81.73, 113.39 -121.19, -164.54 277.36, 113.08 169.85, 169.25 out-none out 13.693 Saltbr-none 999.0 HRD-out -64.39, 111.72 -90.05, -17.06 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.84 APE8-rot-in 294.52 APE67-dihe-out -50.57, -58.17 -66.53, 143.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.263 0.317 A 310 267 15 0 0 15 [[34, 294]] 1.0 6s75 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6NPYB Q8TDX7 113 300 302.0 No_ligand No_ligand Inactive None 999.0 999.0 None -70.39, 159.94 -79.69, -166.49 -68.35, 999.0 292.03, 88.65 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -119.72, -48.43 68.42, -5.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 107.72 APE8-rot-none 999.0 APE67-dihe-out -70.9, -51.67 -73.37, 174.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L54R,V58K,P59T,K87A,A99V,S100C,E103T,D104G None None EM 3.8 999.0 999.0 B 279 188 100 0 0 18 [[34, 294]] 1.0 6npy Homo sapiens NEK_NEK7_HUMAN NEK 7e-109 369.2 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 5DE2B Q8TDX7 20 300 302.0 No_ligand No_ligand Inactive None 999.0 999.0 None -122.26, 169.15 -110.33, -36.5 -85.96, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.616 Saltbr-out 10.406 HRD-in -69.6, -49.19 79.72, -12.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -73.41, -54.18 999.0, 123.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 Y97F None None XRAY 2.78 0.208 0.254 B 310 262 19 0 0 19 [[34, 294]] 1.0 5de2 Homo sapiens NEK_NEK7_HUMAN NEK 1.1e-109 371.9 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S73D Q8TDX7 23 300 302.0 No_ligand No_ligand Inactive None 999.0 999.0 None -142.5, 117.16 -74.81, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.907 Saltbr-none 999.0 HRD-in -71.14, -32.97 72.66, -48.89 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.43 APE8-rot-out 166.85 APE67-dihe-out -54.39, -32.76 -76.19, 149.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L86H,Y97F,L180F None None XRAY 3.5 0.237 0.271 D 310 259 19 0 0 19 [[34, 294]] 1.0 6s73 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-109 369.8 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S76A Q8TDX7 21 300 302.0 No_ligand No_ligand Inactive None 999.0 999.0 None -80.02, -140.08 -107.31, -166.49 -126.34, -163.23 999.0, 999.0 -146.75, 999.0 out-none out 13.145 Saltbr-none 999.0 HRD-in -63.77, -26.33 75.45, -37.94 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na -104.41, 111.55 APE9-dihe-na -64.79, 141.94 APE8-dihe-in -133.77, 121.5 APE8-rot-in 279.99 APE67-dihe-out -60.92, -48.93 -72.08, 150.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.77 None None None XRAY 3.38 0.263 0.286 A 310 266 14 0 0 14 [[34, 294]] 1.0 6s76 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK7_HUMAN 6S76D Q8TDX7 25 300 302.0 No_ligand No_ligand Inactive None 999.0 999.0 None 170.47, 120.54 -53.25, 141.84 -130.46, 999.0 999.0, 999.0 999.0, 999.0 out-none out 16.766 Saltbr-none 999.0 HRD-out -82.4, 102.3 -63.51, -66.82 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 107.43 APE8-rot-none 999.0 APE67-dihe-out -56.39, -29.32 -67.06, 85.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.38 0.263 0.286 D 310 258 18 0 0 18 [[34, 294]] 1.0 6s76 Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7

NEK_NEK7 (Serine/threonine-protein kinase Nek7)

Total number of chains: 0
Active chains: 0
Family: NEK
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name