TYR_JAK3-2 (Tyrosine-protein kinase JAK3)

Total number of chains: 74
Active chains: 8
Uniprot: JAK3_HUMAN
Kinase Domain Residues: 822 - 1097
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 72 97.3% AF-P52333-K2A
DFGin ABAminus 2 2.7% 7C3NA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P52333-K2A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 814 - 1105 0 None None Tyrosine-protein kinase JAK3
AF-P52333-K4A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 814 - 1105 0 None None Tyrosine-protein kinase JAK3
6AAKC 2.67 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9T6 Type1 814 - 1099 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
7UYVA 2.15 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai OV5 Type1 814 - 1100 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
7UYVB 2.15 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai OV5 Type1 814 - 1100 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
3PJCA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PJC Type1 815 - 1104 0 None None Tyrosine-protein kinase JAK3
6GL9A 1.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai F3W Type1 812 - 1103 0 None None Tyrosine-protein kinase JAK3
6GL9B 1.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai F3W Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3
7C3NA 1.98 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai FHX Type1 814 - 1102 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
3LXKA 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai MI1 Type1 815 - 1098 0 None C1048S Tyrosine-protein kinase JAK3
5W86A 2.61 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_nniai APEdist_aaao 9YV Type1 814 - 1098 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
5W86D 2.61 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_nniai APEdist_aaao 9YV Type1 814 - 1099 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
6AAKA 2.67 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 9T6 Type1 815 - 1098 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
6AAKB 2.67 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 9T6 Type1 815 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
3ZC6A 2.42 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_noiai APEdist_aaai VFC Type1 814 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
3ZC6C 2.42 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_nniai APEdist_aaao VFC Type1 814 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
3ZEPA 2.35 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1NX Type1 814 - 1098 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
7UYVC 2.15 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao OV5 Type1 812 - 1100 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
4RIOA 2.69 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 3QX Type1 815 - 1099 0 None C811S,C1040S,C1048S Tyrosine-protein kinase JAK3
5WFJA 2.48 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 9Z4 Type1 817 - 1099 0 None C811S,C1040S,C1048S Tyrosine-protein kinase JAK3
4HVDA 1.85 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 933 Type1 815 - 1101 0 None C1040S,C1048S Tyrosine-protein kinase JAK3
4HVGA 2.75 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 19Q Type1 814 - 1103 0 None C1040S,C1048S Tyrosine-protein kinase JAK3
4HVHA 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 19R Type1 814 - 1102 0 None C1040S,C1048S Tyrosine-protein kinase JAK3
4HVIA 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 19S Type1 815 - 1101 0 None C1040S,C1048S Tyrosine-protein kinase JAK3
4I6QA 1.85 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1DT Type1 815 - 1102 0 None C1040S,C1048S Tyrosine-protein kinase JAK3
4QT1A 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 3C9 Type1 814 - 1102 0 None C1040S,C1048S Tyrosine-protein kinase JAK3
5TOZA 1.98 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7H4 Type1 815 - 1100 0 None None Tyrosine-protein kinase JAK3
5TTSA 2.34 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7KU Type1 814 - 1100 0 None C1048S Tyrosine-protein kinase JAK3
5TTUA 1.72 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7KV Type1 815 - 1099 0 None C1048S Tyrosine-protein kinase JAK3
5TTVA 1.93 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7KX Type1 814 - 1100 0 None C1048S Tyrosine-protein kinase JAK3
6DA4A 2.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai G4V Type1 815 - 1099 0 None C1048S Tyrosine-protein kinase JAK3
6DB3A 1.97 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai G54 Type1 814 - 1100 0 None C1048S Tyrosine-protein kinase JAK3
6DB4A 1.662 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai G4Y Type1 814 - 1100 0 None C1048S Tyrosine-protein kinase JAK3
6DUDA 1.66 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai HB4 Type1 814 - 1100 0 None C1048S Tyrosine-protein kinase JAK3
7Q6HAAA 1.749 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 934 Type1 814 - 1100 0 None None Tyrosine-protein kinase JAK3
3LXLA 1.74 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai IZA Type1 814 - 1098 0 None C1048S Tyrosine-protein kinase JAK3
1YVJA 2.55 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaao 4ST Type1 814 - 1103 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
4Z16B 2.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 4LH Type1 814 - 1103 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
4QPSC 1.8 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_nniai APEdist_aaao 37Q Type1 814 - 1102 0 None D949A,C1040S,C1048S Tyrosine-protein kinase JAK3
5LWMA 1.55 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 79T Type1 814 - 1103 0 None None Tyrosine-protein kinase JAK3
7APFA 1.95 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao RQZ Type1 814 - 1103 0 None None Tyrosine-protein kinase JAK3
7APFB 1.95 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao RQZ Type1 814 - 1103 0 None None Tyrosine-protein kinase JAK3
7APGA 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao RQT Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3
7APGB 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaao RQT Type1 814 - 1103 0 None None Tyrosine-protein kinase JAK3
7APGC 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao RQT Type1 812 - 1103 0 None None Tyrosine-protein kinase JAK3
7APGD 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaao RQT Type1 815 - 1103 0 None None Tyrosine-protein kinase JAK3
5LWNA 1.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 79R, 79S Type1, Type1 814 - 1103 0 None None Tyrosine-protein kinase JAK3
6HZVA 2.46 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan GYW Type1 815 - 1098 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
6HZVB 2.46 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan GYW Type1 815 - 1099 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
6HZVC 2.46 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai GYW Type1 815 - 1098 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
6HZVD 2.46 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai GYW Type1 815 - 1098 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
5W86B 2.61 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 9YV Type1 816 - 1098 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
5W86C 2.61 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 9YV Type1 814 - 1099 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
6AAKD 2.67 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 9T6 Type1 814 - 1098 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
3ZC6B 2.42 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai VFC Type1 813 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
3ZC6D 2.42 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan VFC Type1 814 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
3ZEPB 2.35 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 1NX Type1 814 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
3ZEPC 2.35 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 1NX Type1 814 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
3ZEPD 2.35 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 1NX Type1 814 - 1099 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3
7UYVD 2.15 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai OV5 Type1 814 - 1100 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
5VO6A 2.65 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 9J4 Type1 815 - 1099 0 None C1040S,C1048S Tyrosine-protein kinase JAK3
6NY4A 2.33 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai Z3A Type1 815 - 1099 0 None C811S,C1040S,C1048S Tyrosine-protein kinase JAK3
4V0GB 3.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan G9B Type1 816 - 1098 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
4V0GA 3.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan G9B Type1 817 - 1098 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
4Z16A 2.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 4LH Type1 814 - 1103 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
4Z16C 2.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 4LH Type1 814 - 1103 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
4Z16D 2.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 4LH Type1 814 - 1103 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3
4QPSA 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 37Q Type1 814 - 1100 0 None D949A,C1040S,C1048S Tyrosine-protein kinase JAK3
6GLAA 1.92 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai F4B Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3
6GLAB 1.92 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai F4B Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3
6GLBA 2.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai F48 Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3
6GLBB 2.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai F48 Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3
9R5ZA 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan A1JJU Type1 822 - 1101 0 None None Tyrosine-protein kinase JAK3
9R5ZB 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan A1JJU Type1 816 - 1101 0 None None Tyrosine-protein kinase JAK3

TYR_JAK3-2 (Tyrosine-protein kinase JAK3)

Total number of chains: 74
Active chains: 8
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 72 97.3% AF-P52333-K2A
DFGin ABAminus 2 2.7% 7C3NA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
JAK3_HUMAN AF-P52333-K2A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 814 - 1105 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN AF-P52333-K4A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 814 - 1105 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6AAKC 2.67 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9T6 Type1 814 - 1099 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7UYVA 2.15 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai OV5 Type1 814 - 1100 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7UYVB 2.15 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai OV5 Type1 814 - 1100 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 3PJCA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PJC Type1 815 - 1104 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6GL9A 1.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai F3W Type1 812 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6GL9B 1.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai F3W Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7C3NA 1.98 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai FHX Type1 814 - 1102 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 3LXKA 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai MI1 Type1 815 - 1098 0 None C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5W86A 2.61 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_nniai APEdist_aaao 9YV Type1 814 - 1098 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5W86D 2.61 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_nniai APEdist_aaao 9YV Type1 814 - 1099 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6AAKA 2.67 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 9T6 Type1 815 - 1098 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6AAKB 2.67 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 9T6 Type1 815 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 3ZC6A 2.42 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_noiai APEdist_aaai VFC Type1 814 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 3ZC6C 2.42 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_nniai APEdist_aaao VFC Type1 814 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 3ZEPA 2.35 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1NX Type1 814 - 1098 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7UYVC 2.15 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao OV5 Type1 812 - 1100 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4RIOA 2.69 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 3QX Type1 815 - 1099 0 None C811S,C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5WFJA 2.48 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 9Z4 Type1 817 - 1099 0 None C811S,C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4HVDA 1.85 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 933 Type1 815 - 1101 0 None C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4HVGA 2.75 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 19Q Type1 814 - 1103 0 None C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4HVHA 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 19R Type1 814 - 1102 0 None C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4HVIA 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 19S Type1 815 - 1101 0 None C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4I6QA 1.85 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1DT Type1 815 - 1102 0 None C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4QT1A 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 3C9 Type1 814 - 1102 0 None C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5TOZA 1.98 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7H4 Type1 815 - 1100 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5TTSA 2.34 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7KU Type1 814 - 1100 0 None C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5TTUA 1.72 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7KV Type1 815 - 1099 0 None C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5TTVA 1.93 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 7KX Type1 814 - 1100 0 None C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6DA4A 2.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai G4V Type1 815 - 1099 0 None C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6DB3A 1.97 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai G54 Type1 814 - 1100 0 None C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6DB4A 1.662 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai G4Y Type1 814 - 1100 0 None C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6DUDA 1.66 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai HB4 Type1 814 - 1100 0 None C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7Q6HAAA 1.749 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 934 Type1 814 - 1100 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 3LXLA 1.74 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai IZA Type1 814 - 1098 0 None C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 1YVJA 2.55 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaao 4ST Type1 814 - 1103 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4Z16B 2.9 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 4LH Type1 814 - 1103 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4QPSC 1.8 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_nniai APEdist_aaao 37Q Type1 814 - 1102 0 None D949A,C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5LWMA 1.55 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 79T Type1 814 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7APFA 1.95 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao RQZ Type1 814 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7APFB 1.95 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao RQZ Type1 814 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7APGA 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao RQT Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7APGB 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaao RQT Type1 814 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7APGC 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao RQT Type1 812 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7APGD 2.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaao RQT Type1 815 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5LWNA 1.6 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 79R, 79S Type1, Type1 814 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6HZVA 2.46 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan GYW Type1 815 - 1098 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6HZVB 2.46 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan GYW Type1 815 - 1099 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6HZVC 2.46 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai GYW Type1 815 - 1098 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6HZVD 2.46 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai GYW Type1 815 - 1098 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5W86B 2.61 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 9YV Type1 816 - 1098 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5W86C 2.61 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 9YV Type1 814 - 1099 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6AAKD 2.67 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 9T6 Type1 814 - 1098 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 3ZC6B 2.42 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai VFC Type1 813 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 3ZC6D 2.42 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan VFC Type1 814 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 3ZEPB 2.35 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 1NX Type1 814 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 3ZEPC 2.35 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 1NX Type1 814 - 1100 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 3ZEPD 2.35 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 1NX Type1 814 - 1099 0 PTR980,PTR981 C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 7UYVD 2.15 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai OV5 Type1 814 - 1100 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 5VO6A 2.65 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 9J4 Type1 815 - 1099 0 None C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6NY4A 2.33 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai Z3A Type1 815 - 1099 0 None C811S,C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4V0GB 3.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan G9B Type1 816 - 1098 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4V0GA 3.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan G9B Type1 817 - 1098 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4Z16A 2.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 4LH Type1 814 - 1103 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4Z16C 2.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 4LH Type1 814 - 1103 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4Z16D 2.9 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 4LH Type1 814 - 1103 0 PTR980,PTR981 None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 4QPSA 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan 37Q Type1 814 - 1100 0 None D949A,C1040S,C1048S Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6GLAA 1.92 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai F4B Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6GLAB 1.92 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai F4B Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6GLBA 2.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai F48 Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 6GLBB 2.0 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai F48 Type1 813 - 1103 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 9R5ZA 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan A1JJU Type1 822 - 1101 0 None None Tyrosine-protein kinase JAK3 Homo sapiens
JAK3_HUMAN 9R5ZB 1.8 None DFGin‑BLAminus in-in in-none TYR APEdihe_nnnai APEdist_aaan A1JJU Type1 816 - 1101 0 None None Tyrosine-protein kinase JAK3 Homo sapiens

TYR_JAK3-2 (Tyrosine-protein kinase JAK3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism