TYR_JAK3-2 (Tyrosine-protein kinase JAK3)

Total number of chains: 74
Active chains: 8
Uniprot: JAK3_HUMAN
Kinase Domain Residues: 822 - 1097
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 72 97.3% AF-P52333-K2A
DFGin ABAminus 2 2.7% 7C3NA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
JAK3-2 AF-P52333-K2A P52333 814 1105 1124.0 No_ligand No_ligand Active DFGin 6.1026 13.7936 BLAminus -134.56, -179.19 51.31, 75.31 -82.94, 20.6 292.85, 86.33 -61.55, -30.97 in-in in 8.2483 Saltbr-in 2.6953 HRD-in -70.59, -43.72 65.57, -21.68 in-in-in SNCiii in-in ActLoopNT-in 2.8552 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.42, 123.08 APE9-dihe-in -125.57, 135.88 APE8-dihe-in -78.86, 68.83 APE8-rot-na 34.92 APE67-dihe-in -75.13, -6.36 -53.49, -31.1 APE12-dist-na 10.5223 APE11-dist-na 9.5286 APE10-dist-na 10.1849 APE9-dist-in 7.1879 None None None AF2 -1.0 1.0 1.0 A 292.0 292.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 AF-P52333-K2 TYR_JAK3-2_HUMAN TYR 4.6e-81 277.9 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 AF-P52333-K4A P52333 814 1105 1124.0 No_ligand No_ligand Active DFGin 6.1108 13.7687 BLAminus -141.5, -174.59 54.28, 75.11 -88.15, 17.45 293.92, 89.95 -59.55, -34.59 in-in in 8.1169 Saltbr-in 2.6779 HRD-in -78.79, -45.55 61.88, 0.83 in-in-in SNCiii in-in ActLoopNT-in 2.8819 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.64, 120.49 APE9-dihe-in -128.67, 141.65 APE8-dihe-in -77.57, 68.42 APE8-rot-na 36.41 APE67-dihe-in -72.34, -8.01 -50.71, -34.24 APE12-dist-na 13.4854 APE11-dist-na 9.5574 APE10-dist-na 10.1649 APE9-dist-in 6.4962 None None None AF2 -1.0 1.0 1.0 A 292.0 292.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 AF-P52333-K4 TYR_JAK3-2_HUMAN TYR 4.6e-81 277.9 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6AAKC P52333 814 1099 1124.0 9T6:1201 Type1 Active DFGin 6.7877 14.6346 BLAminus -114.47, 172.4 69.03, 86.81 -107.19, 29.58 286.76, 78.99 -58.47, -55.72 in-in in 8.2406 Saltbr-in 2.7237 HRD-in -89.94, -41.82 71.73, -3.81 in-in-in SNCiii in-in ActLoopNT-in 2.7832 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.85, 76.94 APE9-dihe-in -171.36, 163.86 APE8-dihe-in -58.47, 128.31 APE8-rot-na 338.62 APE67-dihe-in -73.56, -5.95 -79.88, -15.99 APE12-dist-na 12.9746 APE11-dist-na 9.2183 APE10-dist-na 10.3986 APE9-dist-in 7.7513 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.67 0.269 0.326 C 287.0 276.0 10 31 31 0 [[521, 779], [822, 1097]] 2.0 6aak TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7UYVA P52333 814 1100 1124.0 OV5:1201 Type1 Active DFGin 6.3763 14.2869 BLAminus -136.33, -178.14 60.47, 77.06 -94.46, 22.49 283.21, 76.25 -61.39, -33.76 in-in in 8.2009 Saltbr-in 2.6421 HRD-in -69.18, -41.57 72.69, -12.85 in-in-in SNCiii in-in ActLoopNT-in 2.7503 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.18, 82.75 APE9-dihe-in -112.58, 159.26 APE8-dihe-in -47.72, 129.83 APE8-rot-na 329.64 APE67-dihe-in -81.57, 1.11 -69.92, -19.01 APE12-dist-na 11.5311 APE11-dist-na 8.0482 APE10-dist-na 11.6832 APE9-dist-in 7.3388 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 A 291.0 278.0 9 31 31 0 [[521, 779], [822, 1097]] 2.0 7uyv TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7UYVB P52333 814 1100 1124.0 OV5:1201 Type1 Active DFGin 6.2251 14.2162 BLAminus -136.69, -173.44 56.56, 80.52 -96.27, 21.5 284.08, 77.64 -57.68, -39.3 in-in in 8.1504 Saltbr-in 2.6309 HRD-in -80.27, -44.25 68.81, -0.6 in-in-in SNCiii in-in ActLoopNT-in 2.7556 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.34, 85.59 APE9-dihe-in -127.16, 148.54 APE8-dihe-in -37.53, 121.21 APE8-rot-na 325.53 APE67-dihe-in -80.04, -3.68 -72.05, -16.34 APE12-dist-na 11.5779 APE11-dist-na 9.1429 APE10-dist-na 12.2547 APE9-dist-in 7.3873 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 B 291.0 284.0 3 31 31 0 [[521, 779], [822, 1097]] 2.0 7uyv TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 3PJCA P52333 815 1104 1124.0 PJC:800 Type1 Active DFGin 6.6986 14.412 BLAminus -131.65, -174.74 53.97, 85.79 -100.88, 20.12 280.65, 74.1 -60.63, -24.35 in-in in 8.6962 Saltbr-in 2.6139 HRD-in -69.63, -48.63 77.02, -5.32 in-in-in SNCiii in-in ActLoopNT-in 2.8226 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.16, 145.45 APE9-dihe-in -115.3, 150.0 APE8-dihe-in -81.75, 75.29 APE8-rot-na 32.65 APE67-dihe-in -79.59, -4.38 -53.88, -28.84 APE12-dist-na 13.2005 APE11-dist-na 11.5918 APE10-dist-na 12.7974 APE9-dist-in 7.9845 None None None XRAY 2.2 0.182 0.215 A 315.0 286.0 4 31 31 0 [[521, 779], [822, 1097]] 2.0 3pjc TYR_JAK3-2_HUMAN TYR 6.1e-81 277.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6GL9A P52333 812 1103 1124.0 F3W:1201 Type1 Active DFGin 6.2475 14.0115 BLAminus -125.6, -168.17 49.24, 81.71 -98.97, 21.2 279.85, 75.03 -60.06, -26.17 in-in in 7.7934 Saltbr-in 2.6834 HRD-in -78.49, -49.26 75.45, 0.4 in-in-in SNCiii in-in ActLoopNT-in 2.7882 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.67, 117.53 APE9-dihe-in -98.8, 151.13 APE8-dihe-in -79.69, 90.74 APE8-rot-na 31.23 APE67-dihe-in -78.37, -0.16 -59.8, -32.45 APE12-dist-na 9.3301 APE11-dist-na 10.7633 APE10-dist-na 11.753 APE9-dist-in 6.9787 None None None XRAY 1.7 0.209 0.244 A 294.0 292.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 6gl9 TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6GL9B P52333 813 1103 1124.0 F3W:1201 Type1 Active DFGin 6.21 14.019 BLAminus -123.31, -164.34 42.61, 83.03 -97.02, 22.96 280.36, 70.4 -63.87, -26.0 in-in in 7.7595 Saltbr-in 2.667 HRD-in -78.77, -47.46 73.56, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.7746 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.72, 116.63 APE9-dihe-in -97.44, 150.89 APE8-dihe-in -77.79, 91.0 APE8-rot-na 32.15 APE67-dihe-in -73.22, -2.71 -60.01, -35.33 APE12-dist-na 9.3264 APE11-dist-na 10.7827 APE10-dist-na 11.7277 APE9-dist-in 6.9767 None None None XRAY 1.7 0.209 0.244 B 294.0 291.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 6gl9 TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7C3NA P52333 814 1102 1124.0 FHX:9000 Type1 Inactive DFGin 6.068 13.3862 ABAminus -140.24, 14.21 -145.02, 134.62 -131.29, 32.79 294.67, 80.18 -64.88, -27.68 in-in in 8.233 Saltbr-in 2.7822 HRD-in -78.6, -47.11 71.84, 1.59 in-in-in SNCiii in-in ActLoopNT-in 2.8064 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.04, 126.4 APE9-dihe-in -81.7, 145.46 APE8-dihe-in -77.41, 71.31 APE8-rot-na 31.38 APE67-dihe-in -79.88, -2.49 -60.07, -26.59 APE12-dist-na 11.7358 APE11-dist-na 10.4538 APE10-dist-na 12.3096 APE9-dist-in 7.2655 None PTR980,PTR981 PTR980,PTR981 XRAY 1.98 0.17 0.194 A 315.0 289.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 7c3n TYR_JAK3-2_HUMAN TYR 6.1e-81 277.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 3LXKA P52333 815 1098 1124.0 MI1:1125 Type1 Inactive DFGin 6.0647 13.0171 ABAminus -128.16, 7.24 -148.97, 145.15 -138.77, 31.19 300.52, 88.17 -60.03, -27.75 in-in in 8.251 Saltbr-in 2.7565 HRD-in -78.64, -46.72 70.97, -5.63 in-in-out SNCiio in-out ActLoopNT-in 2.8402 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.3, 17.09 APE9-dihe-in -92.59, 156.17 APE8-dihe-in -54.3, 131.46 APE8-rot-na 335.17 APE67-dihe-in -82.42, -7.27 -71.07, -8.83 APE12-dist-na 14.2685 APE11-dist-na 9.9216 APE10-dist-na 10.5049 APE9-dist-in 7.209 C1048S None None XRAY 2.0 0.205 0.265 A 327.0 279.0 5 31 31 0 [[521, 779], [822, 1097]] 2.0 3lxk TYR_JAK3-2_HUMAN TYR 3.2e-81 278.4 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5W86A P52333 814 1098 1124.0 9YV:4000 Type1 Inactive DFGin 6.508 14.2333 BLAminus -130.78, -178.04 55.33, 86.29 -99.45, 24.99 285.64, 80.91 -59.45, -36.09 in-in in 8.3613 Saltbr-in 2.7197 HRD-in -61.74, -49.91 79.02, -19.05 in-in-out SNCiio in-out ActLoopNT-in 2.8338 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -62.63 APE8-dihe-in -73.09, 69.06 APE8-rot-na 28.5 APE67-dihe-in -76.22, -6.14 -68.16, -24.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3257 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 A 287.0 271.0 14 31 26 5 [[521, 779], [822, 1097]] 2.0 5w86 TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5W86D P52333 814 1099 1124.0 9YV:4000 Type1 Inactive DFGin 6.5614 14.2551 BLAminus -130.88, -178.77 56.18, 85.97 -99.02, 25.19 285.73, 80.24 -59.91, -34.36 in-in in 8.1827 Saltbr-in 2.7569 HRD-in -62.59, -49.55 78.85, -19.41 in-in-out SNCiio in-out ActLoopNT-in 2.814 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -64.08 APE8-dihe-in -73.59, 57.74 APE8-rot-na 27.09 APE67-dihe-in -73.08, -10.82 -59.31, -28.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2414 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 D 287.0 274.0 12 31 26 5 [[521, 779], [822, 1097]] 2.0 5w86 TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6AAKA P52333 815 1098 1124.0 9T6:1201 Type1 Inactive DFGin 6.4258 14.4877 BLAminus -141.28, -175.48 60.31, 80.99 -97.75, 30.98 284.74, 77.33 -61.02, -46.05 in-in in 8.5254 Saltbr-in 2.67 HRD-in -75.62, -45.99 77.6, -18.1 in-in-out SNCiio in-out ActLoopNT-in 2.7362 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.2, -11.07 APE9-dihe-in -68.95, 155.07 APE8-dihe-in -47.57, 131.1 APE8-rot-na 329.72 APE67-dihe-in -73.4, -26.9 -66.76, -22.48 APE12-dist-na 11.9929 APE11-dist-na 8.6734 APE10-dist-na 11.3981 APE9-dist-in 7.4704 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.67 0.269 0.326 A 287.0 277.0 7 31 31 0 [[521, 779], [822, 1097]] 2.0 6aak TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6AAKB P52333 815 1100 1124.0 9T6:1201 Type1 Inactive DFGin 6.549 14.3135 BLAminus -132.57, -171.05 56.03, 83.09 -98.42, 24.6 281.38, 75.24 -63.47, -40.11 in-in in 8.0358 Saltbr-in 2.7546 HRD-in -65.5, -48.18 78.33, -13.38 in-in-out SNCiio in-out ActLoopNT-in 2.9074 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.61, -28.55 APE9-dihe-in -64.46, 151.35 APE8-dihe-in -40.19, 130.42 APE8-rot-na 326.93 APE67-dihe-in -77.17, -14.56 -72.74, -10.57 APE12-dist-na 13.1081 APE11-dist-na 9.526 APE10-dist-na 10.0845 APE9-dist-in 7.2029 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.67 0.269 0.326 B 287.0 285.0 1 31 31 0 [[521, 779], [822, 1097]] 2.0 6aak TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 3ZC6A P52333 814 1100 1124.0 VFC:2103 Type1 Inactive DFGin 6.3992 14.249 BLAminus -132.73, -176.21 56.45, 83.25 -97.56, 22.77 285.82, 73.7 -62.6, -27.55 in-in in 8.2919 Saltbr-in 2.8022 HRD-in -72.44, -47.03 73.15, -6.89 in-in-out SNCiio in-out ActLoopNT-in 2.7419 ActLoopCT-out TYR APEdihe_noiai APEdist_aaai APE10-dihe-none 999.0, 118.21 APE9-dihe-out -83.58, -179.01 APE8-dihe-in -60.9, 137.23 APE8-rot-na 332.96 APE67-dihe-in -76.45, -9.26 -65.3, -16.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.5354 APE9-dist-in 5.9074 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 A 288.0 279.0 8 31 27 4 [[521, 779], [822, 1097]] 2.0 3zc6 TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 3ZC6C P52333 814 1100 1124.0 VFC:2103 Type1 Inactive DFGin 6.2807 14.0027 BLAminus -123.64, -177.74 61.16, 80.91 -97.9, 27.04 288.23, 77.53 -66.72, -26.1 in-in in 8.1905 Saltbr-in 2.6842 HRD-in -72.21, -46.31 77.05, -24.4 in-in-out SNCiio in-out ActLoopNT-in 2.7606 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.85 APE8-dihe-in -77.18, 80.1 APE8-rot-na 33.09 APE67-dihe-in -76.9, -10.93 -67.13, -29.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1774 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 C 288.0 277.0 10 31 27 4 [[521, 779], [822, 1097]] 2.0 3zc6 TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 3ZEPA P52333 814 1098 1124.0 1NX:2099 Type1 Inactive DFGin 6.4201 14.3445 BLAminus -139.2, 179.6 58.57, 83.63 -103.43, 28.82 290.46, 79.48 -67.26, -39.4 in-in in 8.1983 Saltbr-in 2.7236 HRD-in -72.97, -44.84 72.81, -0.01 in-in-out SNCiio in-out ActLoopNT-in 2.7642 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -90.83, 0.53 APE9-dihe-in -141.71, 168.37 APE8-dihe-in -61.5, 133.7 APE8-rot-na 333.46 APE67-dihe-in -72.33, -1.68 -64.6, -21.71 APE12-dist-na 13.4306 APE11-dist-na 10.6555 APE10-dist-na 6.8245 APE9-dist-in 6.4001 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 A 288.0 276.0 9 31 31 0 [[521, 779], [822, 1097]] 2.0 3zep TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7UYVC P52333 812 1100 1124.0 OV5:1201 Type1 Inactive DFGin 6.5497 14.2474 BLAminus -139.0, -178.89 62.41, 84.96 -102.47, 24.54 285.05, 80.61 -63.66, -34.31 in-in in 8.1764 Saltbr-in 2.7239 HRD-in -72.48, -47.02 76.02, -14.38 in-in-out SNCiio in-out ActLoopNT-in 2.6962 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -72.04, 75.71 APE9-dihe-in -159.34, 174.75 APE8-dihe-in -55.7, 114.03 APE8-rot-na 331.85 APE67-dihe-in -81.89, -1.84 -68.05, -12.84 APE12-dist-na 12.9994 APE11-dist-na 8.9457 APE10-dist-na 10.9307 APE9-dist-out 8.0032 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 C 291.0 281.0 8 31 31 0 [[521, 779], [822, 1097]] 2.0 7uyv TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4RIOA P52333 815 1099 1124.0 3QX:4000 Type1 Inactive DFGin 6.3935 13.5705 BLAminus -146.26, -172.55 60.58, 82.0 -101.14, 19.19 286.89, 85.95 -65.85, -24.53 in-in in 7.6666 Saltbr-in 2.8105 HRD-in -70.94, -43.53 62.59, 2.86 in-in-out SNCiio in-out ActLoopNT-in 2.9783 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -135.63, 27.38 APE9-dihe-in -118.75, 159.28 APE8-dihe-in -55.16, 127.94 APE8-rot-na 333.58 APE67-dihe-in -76.1, -3.72 -64.2, -13.91 APE12-dist-na 12.5847 APE11-dist-na 9.8864 APE10-dist-na 9.9276 APE9-dist-in 7.1524 C811S,C1040S,C1048S None None XRAY 2.69 0.218 0.281 A 293.0 285.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 4rio TYR_JAK3-2_HUMAN TYR 2.1e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5WFJA P52333 817 1099 1124.0 9Z4:4000 Type1 Inactive DFGin 6.5811 13.8338 BLAminus -136.44, -170.83 58.73, 75.78 -96.48, 23.06 286.97, 86.34 -64.05, -24.53 in-in in 7.6299 Saltbr-in 2.8738 HRD-in -76.6, -46.72 68.06, 1.53 in-in-out SNCiio in-out ActLoopNT-in 2.9182 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.32, 20.43 APE9-dihe-in -103.33, 153.28 APE8-dihe-in -50.05, 126.35 APE8-rot-na 333.7 APE67-dihe-in -76.71, 0.96 -65.58, -12.14 APE12-dist-na 13.631 APE11-dist-na 9.8634 APE10-dist-na 10.1142 APE9-dist-in 7.0412 C811S,C1040S,C1048S None None XRAY 2.48 0.205 0.255 A 293.0 265.0 18 31 29 2 [[521, 779], [822, 1097]] 2.0 5wfj TYR_JAK3-2_HUMAN TYR 2.1e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4HVDA P52333 815 1101 1124.0 933:1202 Type1 Inactive DFGin 6.5272 14.0171 BLAminus -128.55, -166.42 58.39, 76.56 -98.5, 22.97 288.27, 78.76 -65.56, -24.6 in-in in 8.047 Saltbr-in 2.8425 HRD-in -70.62, -50.61 83.01, -13.8 in-in-out SNCiio in-out ActLoopNT-in 2.8441 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -120.35, 6.88 APE9-dihe-in -87.79, 153.51 APE8-dihe-in -47.35, 128.71 APE8-rot-na 328.03 APE67-dihe-in -81.29, -0.66 -70.05, -11.78 APE12-dist-na 13.6702 APE11-dist-na 9.8379 APE10-dist-na 10.1082 APE9-dist-in 7.3252 C1040S,C1048S None None XRAY 1.85 0.225 0.259 A 314.0 276.0 11 31 31 0 [[521, 779], [822, 1097]] 2.0 4hvd TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4HVGA P52333 814 1103 1124.0 19Q:1201 Type1 Inactive DFGin 6.3691 14.0706 BLAminus -130.41, -171.25 53.38, 75.08 -85.23, 20.51 289.87, 75.57 -58.89, -29.62 in-in in 8.256 Saltbr-in 2.8006 HRD-in -81.72, -46.13 83.55, -16.25 in-in-out SNCiio in-out ActLoopNT-in 2.9723 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -135.6, 18.04 APE9-dihe-in -102.46, 155.94 APE8-dihe-in -50.03, 129.65 APE8-rot-na 326.24 APE67-dihe-in -77.88, -2.28 -61.37, -21.51 APE12-dist-na 13.6391 APE11-dist-na 9.8591 APE10-dist-na 10.1069 APE9-dist-in 7.4421 C1040S,C1048S None None XRAY 2.75 0.214 0.274 A 314.0 281.0 9 31 31 0 [[521, 779], [822, 1097]] 2.0 4hvg TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4HVHA P52333 814 1102 1124.0 19R:1201 Type1 Inactive DFGin 6.4361 14.1039 BLAminus -140.81, -174.18 54.94, 86.96 -103.32, 27.47 289.17, 75.35 -59.86, -26.99 in-in in 8.1031 Saltbr-in 2.73 HRD-in -70.65, -47.69 79.95, -7.3 in-in-out SNCiio in-out ActLoopNT-in 2.8656 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -125.66, 18.79 APE9-dihe-in -103.72, 157.23 APE8-dihe-in -46.25, 127.99 APE8-rot-na 329.23 APE67-dihe-in -82.32, 1.96 -65.92, -16.55 APE12-dist-na 13.6054 APE11-dist-na 9.7978 APE10-dist-na 10.0657 APE9-dist-in 7.3949 C1040S,C1048S None None XRAY 2.3 0.23 0.283 A 314.0 278.0 11 31 31 0 [[521, 779], [822, 1097]] 2.0 4hvh TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4HVIA P52333 815 1101 1124.0 19S:1201 Type1 Inactive DFGin 6.4427 13.9006 BLAminus -133.13, -169.35 58.25, 80.79 -103.46, 21.02 290.11, 82.66 -64.8, -24.06 in-in in 8.1481 Saltbr-in 2.7134 HRD-in -70.83, -44.69 73.14, -9.21 in-in-out SNCiio in-out ActLoopNT-in 3.0118 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.42, 8.91 APE9-dihe-in -93.49, 161.0 APE8-dihe-in -50.05, 128.83 APE8-rot-na 327.89 APE67-dihe-in -77.81, -4.37 -61.08, -19.7 APE12-dist-na 13.3068 APE11-dist-na 9.5384 APE10-dist-na 9.8434 APE9-dist-in 7.267 C1040S,C1048S None None XRAY 2.4 0.238 0.303 A 314.0 274.0 13 31 31 0 [[521, 779], [822, 1097]] 2.0 4hvi TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4I6QA P52333 815 1102 1124.0 1DT:1202 Type1 Inactive DFGin 6.5477 13.8797 BLAminus -122.27, -166.37 58.65, 80.25 -102.66, 18.99 282.73, 92.38 -63.16, -27.69 in-in in 8.1701 Saltbr-in 2.6678 HRD-in -82.65, -46.76 80.12, -11.61 in-in-out SNCiio in-out ActLoopNT-in 2.8258 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.82, 1.26 APE9-dihe-in -88.25, 159.4 APE8-dihe-in -50.29, 130.77 APE8-rot-na 324.04 APE67-dihe-in -86.64, 4.17 -68.93, -13.66 APE12-dist-na 13.7233 APE11-dist-na 9.8721 APE10-dist-na 9.9493 APE9-dist-in 7.3231 C1040S,C1048S None None XRAY 1.85 0.198 0.245 A 314.0 277.0 11 31 31 0 [[521, 779], [822, 1097]] 2.0 4i6q TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4QT1A P52333 814 1102 1124.0 3C9:1201 Type1 Inactive DFGin 6.6492 13.9762 BLAminus -139.02, 177.24 52.6, 80.83 -91.99, 24.19 292.74, 76.91 -57.05, -27.61 in-in in 7.854 Saltbr-in 2.8081 HRD-in -76.1, -42.64 74.06, 0.56 in-in-out SNCiio in-out ActLoopNT-in 2.8439 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.55, 16.0 APE9-dihe-in -104.71, 155.27 APE8-dihe-in -51.8, 130.25 APE8-rot-na 330.69 APE67-dihe-in -80.61, -3.03 -68.8, -13.83 APE12-dist-na 13.5093 APE11-dist-na 9.8141 APE10-dist-na 9.9829 APE9-dist-in 7.1611 C1040S,C1048S None None XRAY 2.4 0.21 0.273 A 314.0 277.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 4qt1 TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5TOZA P52333 815 1100 1124.0 7H4:1201 Type1 Inactive DFGin 6.4346 14.1797 BLAminus -132.42, -172.67 55.17, 83.47 -97.89, 23.39 288.4, 75.31 -59.42, -27.52 in-in in 8.0531 Saltbr-in 2.7698 HRD-in -70.7, -45.74 70.21, -7.3 in-in-out SNCiio in-out ActLoopNT-in 2.8052 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.82, 11.45 APE9-dihe-in -93.23, 156.46 APE8-dihe-in -46.82, 125.7 APE8-rot-na 327.47 APE67-dihe-in -74.64, -1.89 -65.68, -15.53 APE12-dist-na 13.7154 APE11-dist-na 9.6672 APE10-dist-na 10.1541 APE9-dist-in 7.336 None None None XRAY 1.98 0.184 0.215 A 321.0 278.0 8 31 31 0 [[521, 779], [822, 1097]] 2.0 5toz TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5TTSA P52333 814 1100 1124.0 7KU:4000 Type1 Inactive DFGin 6.4256 14.158 BLAminus -129.0, -169.11 47.63, 82.34 -97.79, 20.5 281.57, 83.57 -59.54, -22.32 in-in in 7.8793 Saltbr-in 2.727 HRD-in -71.68, -45.64 72.69, -11.39 in-in-out SNCiio in-out ActLoopNT-in 2.8295 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -120.94, 5.03 APE9-dihe-in -92.95, 155.15 APE8-dihe-in -50.68, 128.91 APE8-rot-na 333.75 APE67-dihe-in -73.89, 0.34 -64.16, -15.93 APE12-dist-na 13.6385 APE11-dist-na 9.8268 APE10-dist-na 9.9629 APE9-dist-in 7.3964 C1048S None None XRAY 2.34 0.205 0.263 A 321.0 274.0 13 31 31 0 [[521, 779], [822, 1097]] 2.0 5tts TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5TTUA P52333 815 1099 1124.0 7KV:1201 Type1 Inactive DFGin 6.5073 14.2203 BLAminus -134.44, -163.93 59.24, 64.07 -87.63, 14.18 281.02, 85.09 -61.33, -21.77 in-in in 8.1783 Saltbr-in 2.6873 HRD-in -74.44, -46.15 74.73, -11.09 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.51, 0.99 APE9-dihe-in -84.97, 156.58 APE8-dihe-in -52.23, 128.18 APE8-rot-na 331.46 APE67-dihe-in -73.87, -5.17 -63.29, -14.0 APE12-dist-na 13.6239 APE11-dist-na 9.6774 APE10-dist-na 9.9919 APE9-dist-in 7.2843 C1048S None None XRAY 1.72 0.193 0.212 A 321.0 271.0 14 31 31 0 [[521, 779], [822, 1097]] 2.0 5ttu TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5TTVA P52333 814 1100 1124.0 7KX:4000 Type1 Inactive DFGin 6.389 13.9545 BLAminus -134.13, -173.38 47.72, 81.12 -99.64, 24.47 284.98, 81.27 -61.89, -30.49 in-in in 7.571 Saltbr-in 2.7566 HRD-in -68.58, -49.94 77.2, -11.61 in-in-out SNCiio in-out ActLoopNT-in 2.887 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.83, -8.71 APE9-dihe-in -81.68, 166.25 APE8-dihe-in -54.83, 134.34 APE8-rot-na 333.98 APE67-dihe-in -68.58, -14.21 -64.91, -25.89 APE12-dist-na 13.454 APE11-dist-na 10.1045 APE10-dist-na 9.8444 APE9-dist-in 7.0476 C1048S None None XRAY 1.93 0.195 0.25 A 321.0 280.0 7 31 31 0 [[521, 779], [822, 1097]] 2.0 5ttv TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6DA4A P52333 815 1099 1124.0 G4V:1201 Type1 Inactive DFGin 6.3399 14.1592 BLAminus -125.34, -166.51 46.1, 93.47 -106.56, 19.65 286.03, 81.95 -61.5, -24.21 in-in in 8.0349 Saltbr-in 2.8116 HRD-in -66.39, -43.11 68.24, -5.72 in-in-out SNCiio in-out ActLoopNT-in 2.8446 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -76.16, 17.06 APE9-dihe-in -99.01, 151.3 APE8-dihe-in -54.06, 116.09 APE8-rot-na 335.02 APE67-dihe-in -66.76, -9.61 -46.02, -19.91 APE12-dist-na 13.2424 APE11-dist-na 9.376 APE10-dist-na 10.3711 APE9-dist-in 7.2615 C1048S None None XRAY 2.9 0.229 0.263 A 321.0 281.0 4 31 31 0 [[521, 779], [822, 1097]] 2.0 6da4 TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6DB3A P52333 814 1100 1124.0 G54:4000 Type1 Inactive DFGin 6.286 13.9012 BLAminus -131.89, -177.11 58.86, 88.06 -99.15, 20.97 289.91, 81.31 -57.3, -32.4 in-in in 8.2338 Saltbr-in 2.6892 HRD-in -69.32, -44.77 72.88, -9.11 in-in-out SNCiio in-out ActLoopNT-in 2.7455 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.94, 10.67 APE9-dihe-in -91.58, 152.91 APE8-dihe-in -48.92, 124.78 APE8-rot-na 329.3 APE67-dihe-in -70.97, -6.33 -60.73, -15.87 APE12-dist-na 13.7116 APE11-dist-na 9.5497 APE10-dist-na 10.1421 APE9-dist-in 7.3914 C1048S None None XRAY 1.97 0.19 0.224 A 321.0 275.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 6db3 TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6DB4A P52333 814 1100 1124.0 G4Y:4000 Type1 Inactive DFGin 6.3293 13.8866 BLAminus -129.96, -177.19 65.04, 85.51 -102.45, 21.04 283.09, 83.98 -63.09, -23.83 in-in in 8.1031 Saltbr-in 2.6779 HRD-in -75.95, -47.04 72.28, -5.11 in-in-out SNCiio in-out ActLoopNT-in 2.844 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.18, 10.26 APE9-dihe-in -87.73, 153.8 APE8-dihe-in -51.18, 129.01 APE8-rot-na 329.23 APE67-dihe-in -72.48, -3.98 -65.43, -15.27 APE12-dist-na 14.0574 APE11-dist-na 9.8642 APE10-dist-na 10.2997 APE9-dist-in 7.1511 C1048S None None XRAY 1.662 0.187 0.216 A 321.0 276.0 11 31 31 0 [[521, 779], [822, 1097]] 2.0 6db4 TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6DUDA P52333 814 1100 1124.0 HB4:1201 Type1 Inactive DFGin 6.3774 14.08 BLAminus -130.37, -174.96 58.79, 79.77 -94.85, 21.4 284.9, 80.47 -61.75, -24.01 in-in in 7.8751 Saltbr-in 2.7643 HRD-in -71.12, -48.96 73.72, -5.63 in-in-out SNCiio in-out ActLoopNT-in 2.844 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.73, 7.91 APE9-dihe-in -89.0, 155.98 APE8-dihe-in -50.13, 125.96 APE8-rot-na 330.56 APE67-dihe-in -75.78, -4.72 -64.96, -12.29 APE12-dist-na 14.024 APE11-dist-na 9.7788 APE10-dist-na 10.0218 APE9-dist-in 7.0938 C1048S None None XRAY 1.66 0.185 0.215 A 321.0 272.0 15 31 31 0 [[521, 779], [822, 1097]] 2.0 6dud TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7Q6HAAA P52333 814 1100 1124.0 934:1201 Type1 Inactive DFGin 6.4415 13.9124 BLAminus -128.11, -171.29 67.58, 71.88 -97.45, 20.62 287.7, 81.42 -64.43, -23.85 in-in in 7.9084 Saltbr-in 2.684 HRD-in -72.1, -52.28 82.4, -12.01 in-in-out SNCiio in-out ActLoopNT-in 2.789 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.93, 11.02 APE9-dihe-in -86.89, 152.23 APE8-dihe-in -44.63, 129.97 APE8-rot-na 328.93 APE67-dihe-in -80.65, 0.41 -70.73, -15.65 APE12-dist-na 13.7773 APE11-dist-na 9.7373 APE10-dist-na 10.3425 APE9-dist-in 7.2322 None None None XRAY 1.749 0.185 0.22 AAA 327.0 282.0 5 31 31 0 [[521, 779], [822, 1097]] 2.0 7q6h TYR_JAK3-2_HUMAN TYR 3.1e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 3LXLA P52333 814 1098 1124.0 IZA:1 Type1 Inactive DFGin 6.3563 13.9832 BLAminus -131.21, -163.1 63.94, 61.73 -90.52, 13.42 287.27, 88.72 -63.24, -20.77 in-in in 7.8734 Saltbr-in 2.759 HRD-in -76.94, -49.02 80.12, -11.64 in-in-out SNCiio in-out ActLoopNT-in 2.8049 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -131.67, 15.09 APE9-dihe-in -90.67, 156.23 APE8-dihe-in -48.41, 132.69 APE8-rot-na 328.44 APE67-dihe-in -80.87, -3.57 -71.39, -11.92 APE12-dist-na 13.8943 APE11-dist-na 9.8069 APE10-dist-na 10.408 APE9-dist-in 7.3708 C1048S None None XRAY 1.74 0.195 0.227 A 327.0 281.0 4 31 31 0 [[521, 779], [822, 1097]] 2.0 3lxl TYR_JAK3-2_HUMAN TYR 3.2e-81 278.4 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 1YVJA P52333 814 1103 1124.0 4ST:2000 Type1 Inactive DFGin 6.5054 14.0048 BLAminus -117.35, -176.34 48.83, 98.04 -113.48, 29.61 287.79, 84.73 -71.88, -20.61 in-in in 8.6181 Saltbr-in 2.8369 HRD-in -75.54, -39.16 74.88, -34.81 in-in-out SNCiio in-out ActLoopNT-in 2.8318 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.81, -5.63 APE9-dihe-in -95.15, 159.49 APE8-dihe-in -47.0, 152.52 APE8-rot-na 325.56 APE67-dihe-in -77.97, 4.18 -53.16, -16.76 APE12-dist-na 9.8059 APE11-dist-na 6.854 APE10-dist-na 8.7777 APE9-dist-out 8.1995 None PTR980,PTR981 PTR980,PTR981 XRAY 2.55 0.204 0.254 A 290.0 290.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 1yvj TYR_JAK3-2_HUMAN TYR 5.4e-81 277.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4Z16B P52333 814 1103 1124.0 4LH:2000 Type1 Inactive DFGin 6.6659 14.5322 BLAminus -124.7, -170.19 45.77, 83.37 -100.74, 26.17 289.95, 82.89 -68.35, -28.49 in-in in 8.3877 Saltbr-in 2.8503 HRD-in -66.49, -45.94 73.56, -20.74 in-in-out SNCiio in-out ActLoopNT-in 2.8618 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -56.65, -6.62 APE9-dihe-in -78.46, 132.64 APE8-dihe-in -45.17, 131.02 APE8-rot-na 5.36 APE67-dihe-in -79.95, -14.25 -79.37, 1.19 APE12-dist-na 12.5366 APE11-dist-na 9.232 APE10-dist-na 10.615 APE9-dist-in 7.017 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 B 316.0 278.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 4z16 TYR_JAK3-2_HUMAN TYR 7.5e-81 277.2 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4QPSC P52333 814 1102 1124.0 37Q:1201 Type1 Inactive DFGin 6.7747 14.2003 BLAminus -137.32, -176.14 60.46, 91.64 -108.44, 19.09 284.35, 76.96 -56.92, -26.19 in-in in 8.5021 Saltbr-in 2.8029 HRD-in -82.86, -44.58 73.92, -46.68 in-in-out SNCiio in-out ActLoopNT-in 2.8214 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.79 APE8-dihe-in -74.25, 110.88 APE8-rot-na 352.69 APE67-dihe-in -70.61, -6.19 -68.78, -23.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.9914 D949A,C1040S,C1048S None None XRAY 1.8 0.21 0.251 C 293.0 276.0 13 31 26 5 [[521, 779], [822, 1097]] 2.0 4qps TYR_JAK3-2_HUMAN TYR 3.9e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5LWMA P52333 814 1103 1124.0 79T:1201 Type1 Inactive DFGin 6.1807 14.0847 BLAminus -127.82, -164.11 50.78, 78.32 -96.87, 23.57 279.03, 70.69 -64.42, -25.51 in-in in 7.8434 Saltbr-in 2.7715 HRD-in -83.79, -41.29 73.45, -47.71 in-in-out SNCiio in-out ActLoopNT-in 2.8732 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -137.31, 98.87 APE9-dihe-in -108.79, 137.75 APE8-dihe-in -66.78, 85.64 APE8-rot-na 29.56 APE67-dihe-in -76.19, -3.82 -62.47, -28.25 APE12-dist-na 10.173 APE11-dist-na 13.4615 APE10-dist-na 12.5843 APE9-dist-out 8.869 None None None XRAY 1.55 0.166 0.204 A 294.0 290.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 5lwm TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7APFA P52333 814 1103 1124.0 RQZ:1201 Type1 Inactive DFGin 6.1423 14.108 BLAminus -125.02, -164.76 52.74, 82.07 -99.72, 24.14 279.87, 69.9 -58.8, -33.19 in-in in 8.0164 Saltbr-in 2.735 HRD-in -77.19, -45.73 75.08, -49.11 in-in-out SNCiio in-out ActLoopNT-in 2.8014 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -141.26, 128.28 APE9-dihe-in -143.67, 157.99 APE8-dihe-in -81.92, 93.49 APE8-rot-na 7.76 APE67-dihe-in -79.55, -5.28 -69.3, -23.78 APE12-dist-na 10.1511 APE11-dist-na 13.6863 APE10-dist-na 13.2698 APE9-dist-out 9.0224 None None None XRAY 1.95 0.206 0.255 A 294.0 290.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 7apf TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7APFB P52333 814 1103 1124.0 RQZ:1201 Type1 Inactive DFGin 6.2636 13.9552 BLAminus -125.48, -163.38 48.35, 84.73 -99.0, 25.48 280.41, 70.13 -63.69, -28.85 in-in in 8.0989 Saltbr-in 2.7319 HRD-in -80.63, -44.7 74.93, -48.31 in-in-out SNCiio in-out ActLoopNT-in 2.7771 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -141.78, 126.08 APE9-dihe-in -146.46, 155.19 APE8-dihe-in -90.31, 98.72 APE8-rot-na 9.96 APE67-dihe-in -78.0, -2.22 -75.31, -23.81 APE12-dist-na 9.6188 APE11-dist-na 13.0285 APE10-dist-na 12.5423 APE9-dist-out 9.1313 None None None XRAY 1.95 0.206 0.255 B 294.0 285.0 5 31 31 0 [[521, 779], [822, 1097]] 2.0 7apf TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7APGA P52333 813 1103 1124.0 RQT:61201 Type1 Inactive DFGin 6.0309 13.9524 BLAminus -145.19, -172.66 53.39, 85.17 -97.7, 25.99 284.4, 73.93 -62.87, -25.47 in-in in 8.4915 Saltbr-in 3.0886 HRD-in -83.97, -50.23 79.99, -46.84 in-in-out SNCiio in-out ActLoopNT-in 2.9125 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -120.14, 50.45 APE9-dihe-in -76.86, 156.83 APE8-dihe-in -73.67, 136.77 APE8-rot-na 351.29 APE67-dihe-in -81.27, -2.59 -94.73, -13.37 APE12-dist-na 10.6785 APE11-dist-na 10.8995 APE10-dist-na 13.6012 APE9-dist-out 8.9847 None None None XRAY 2.4 0.214 0.256 A 294.0 279.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 7apg TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7APGB P52333 814 1103 1124.0 RQT:61201 Type1 Inactive DFGin 6.0387 14.0695 BLAminus -144.05, -171.58 55.33, 84.79 -97.11, 25.47 284.03, 75.74 -64.12, -25.92 in-in in 8.44 Saltbr-in 3.0791 HRD-in -83.8, -49.69 80.24, -45.58 in-in-out SNCiio in-out ActLoopNT-in 2.9057 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -121.16, 48.46 APE9-dihe-in -74.89, 156.25 APE8-dihe-in -72.87, 137.28 APE8-rot-na 354.01 APE67-dihe-in -82.99, -1.84 -93.81, -9.25 APE12-dist-na 10.8058 APE11-dist-na 10.8121 APE10-dist-na 13.4192 APE9-dist-out 8.9175 None None None XRAY 2.4 0.214 0.256 B 294.0 278.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 7apg TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7APGC P52333 812 1103 1124.0 RQT:61201 Type1 Inactive DFGin 6.0574 14.0501 BLAminus -143.35, -172.89 56.23, 84.96 -97.07, 24.64 284.44, 74.77 -64.51, -25.55 in-in in 8.468 Saltbr-in 3.0668 HRD-in -82.68, -50.65 80.68, -46.32 in-in-out SNCiio in-out ActLoopNT-in 2.9124 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -120.01, 55.65 APE9-dihe-in -74.89, 157.1 APE8-dihe-in -74.45, 136.81 APE8-rot-na 351.06 APE67-dihe-in -81.76, -1.91 -93.74, -14.98 APE12-dist-na 10.5477 APE11-dist-na 11.1621 APE10-dist-na 13.9629 APE9-dist-out 8.9485 None None None XRAY 2.4 0.214 0.256 C 294.0 287.0 5 31 31 0 [[521, 779], [822, 1097]] 2.0 7apg TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7APGD P52333 815 1103 1124.0 RQT:61201 Type1 Inactive DFGin 6.0092 14.041 BLAminus -143.73, -171.03 51.78, 85.49 -96.62, 26.59 283.85, 72.76 -64.13, -26.23 in-in in 8.434 Saltbr-in 3.0873 HRD-in -83.66, -49.57 81.52, -47.38 in-in-out SNCiio in-out ActLoopNT-in 2.9154 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -120.66, 45.43 APE9-dihe-in -76.74, 156.2 APE8-dihe-in -73.01, 137.72 APE8-rot-na 354.08 APE67-dihe-in -79.85, -1.41 -95.44, -12.08 APE12-dist-na 10.8366 APE11-dist-na 10.5366 APE10-dist-na 13.2359 APE9-dist-out 8.9582 None None None XRAY 2.4 0.214 0.256 D 294.0 277.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 7apg TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5LWNA P52333 814 1103 1124.0 79R:1208,79S:1209 Type1,Type1 Inactive DFGin 6.1459 14.132 BLAminus -129.49, -162.36 48.02, 73.73 -88.01, 20.06 281.83, 72.86 -61.77, -25.11 in-in in 7.8172 Saltbr-in 2.7083 HRD-in -84.52, -44.16 75.64, -46.25 in-in-out SNCiio in-out ActLoopNT-in 2.8251 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -141.38, 98.08 APE9-dihe-in -113.86, 140.78 APE8-dihe-in -73.27, 87.08 APE8-rot-na 29.33 APE67-dihe-in -77.95, -2.97 -61.74, -27.63 APE12-dist-na 10.0824 APE11-dist-na 13.4052 APE10-dist-na 12.4459 APE9-dist-out 8.904 None None None XRAY 1.6 0.169 0.209 A 294.0 290.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 5lwn TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6HZVA P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.4293 14.257 BLAminus -133.87, 178.6 61.51, 90.4 -109.85, 28.17 289.99, 77.52 -67.6, -31.52 in-in in 8.3241 Saltbr-in 2.9312 HRD-in -62.66, -43.13 71.32, -8.68 in-in-none SNCiin in-none ActLoopNT-in 2.7324 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 119.68 APE8-rot-na 14.07 APE67-dihe-in -79.55, -1.3 -80.03, -13.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 A 285.0 266.0 18 31 26 5 [[521, 779], [822, 1097]] 2.0 6hzv TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6HZVB P52333 815 1099 1124.0 GYW:1101 Type1 None DFGin 6.1943 14.2143 BLAminus -135.38, 176.48 64.47, 86.88 -105.43, 20.89 286.69, 85.17 -66.35, -29.51 in-in in 8.1494 Saltbr-in 2.8265 HRD-in -61.18, -44.44 71.7, 4.93 in-in-none SNCiin in-none ActLoopNT-in 2.6907 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 129.11 APE8-rot-na 330.57 APE67-dihe-in -79.98, -2.63 -77.74, -18.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 B 285.0 269.0 16 31 25 6 [[521, 779], [822, 1097]] 2.0 6hzv TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6HZVC P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.477 14.2719 BLAminus -130.86, 179.06 58.44, 90.28 -109.09, 23.07 290.05, 84.12 -62.59, -33.96 in-in in 8.0905 Saltbr-in 2.8088 HRD-in -69.82, -48.24 78.15, -8.29 in-in-none SNCiin in-none ActLoopNT-in 2.6892 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -41.25 APE8-dihe-in -66.72, 131.5 APE8-rot-na 341.69 APE67-dihe-in -75.5, -7.29 -73.63, -18.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.346 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 C 285.0 265.0 19 31 26 5 [[521, 779], [822, 1097]] 2.0 6hzv TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6HZVD P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.418 14.1518 BLAminus -133.07, -178.12 58.66, 85.08 -104.02, 25.84 292.67, 81.24 -61.98, -32.78 in-in in 8.1402 Saltbr-in 2.7701 HRD-in -71.74, -43.92 75.22, -14.51 in-in-none SNCiin in-none ActLoopNT-in 2.7079 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -35.5 APE8-dihe-in -66.27, 131.93 APE8-rot-na 340.52 APE67-dihe-in -79.97, 1.1 -77.2, -17.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6337 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 D 285.0 259.0 25 31 26 5 [[521, 779], [822, 1097]] 2.0 6hzv TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5W86B P52333 816 1098 1124.0 9YV:4000 Type1 None DFGin 6.5719 14.1258 BLAminus -130.89, -177.7 55.33, 86.59 -98.74, 23.53 285.65, 80.73 -58.36, -36.34 in-in in 8.1755 Saltbr-in 2.7815 HRD-in -61.09, -43.56 75.39, -22.05 in-in-none SNCiin in-none ActLoopNT-in 2.8266 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-in -98.06, 144.28 APE8-rot-na 28.22 APE67-dihe-in -84.46, -5.87 -122.29, -17.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7561 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 B 287.0 269.0 14 31 26 5 [[521, 779], [822, 1097]] 2.0 5w86 TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5W86C P52333 814 1099 1124.0 9YV:4000 Type1 None DFGin 6.5069 14.1113 BLAminus -131.5, -178.51 55.57, 86.1 -97.59, 23.31 285.7, 80.13 -57.67, -36.43 in-in in 8.1655 Saltbr-in 2.9403 HRD-in -62.63, -48.44 77.31, -20.33 in-in-none SNCiin in-none ActLoopNT-in 2.8223 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -67.29 APE8-rot-na 15.79 APE67-dihe-in -70.13, -18.29 -58.03, -20.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 C 287.0 275.0 11 31 25 6 [[521, 779], [822, 1097]] 2.0 5w86 TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6AAKD P52333 814 1098 1124.0 9T6:1201 Type1 None DFGin 6.3309 14.1383 BLAminus -145.03, 168.99 56.55, 97.11 -103.75, 32.24 293.47, 81.71 -62.01, -33.71 in-in in 8.0179 Saltbr-in 2.8556 HRD-in -76.49, -42.81 76.74, -36.27 in-in-none SNCiin in-none ActLoopNT-in 2.7662 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 72.65 APE8-dihe-in -50.29, 134.06 APE8-rot-na 332.19 APE67-dihe-in -63.85, -16.03 -70.13, -20.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3842 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.67 0.269 0.326 D 287.0 268.0 17 31 26 5 [[521, 779], [822, 1097]] 2.0 6aak TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 3ZC6B P52333 813 1100 1124.0 VFC:2103 Type1 None DFGin 6.2181 14.0462 BLAminus -128.88, -176.96 59.69, 81.97 -99.61, 22.0 289.18, 82.46 -63.53, -20.72 in-in in 8.2087 Saltbr-in 2.7991 HRD-in -71.31, -49.71 79.31, 3.34 in-in-none SNCiin in-none ActLoopNT-in 2.7475 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 25.15 APE9-dihe-in -99.95, 171.81 APE8-dihe-in -50.02, 112.29 APE8-rot-na 325.04 APE67-dihe-in -73.29, -4.3 -58.87, -25.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.4818 APE9-dist-in 6.8402 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 B 288.0 278.0 10 31 27 4 [[521, 779], [822, 1097]] 2.0 3zc6 TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 3ZC6D P52333 814 1100 1124.0 VFC:2103 Type1 None DFGin 6.3147 14.132 BLAminus -134.59, -176.68 59.2, 81.95 -97.58, 24.75 285.45, 76.49 -66.73, -25.04 in-in in 8.057 Saltbr-in 2.7416 HRD-in -74.86, -52.02 77.99, -12.75 in-in-none SNCiin in-none ActLoopNT-in 2.7303 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 79.2 APE8-rot-na 32.25 APE67-dihe-in -80.63, -5.09 -78.85, -21.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 D 288.0 269.0 18 31 26 5 [[521, 779], [822, 1097]] 2.0 3zc6 TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 3ZEPB P52333 814 1100 1124.0 1NX:2101 Type1 None DFGin 6.3528 14.2219 BLAminus -142.2, 177.46 62.39, 84.45 -101.38, 32.38 292.96, 77.07 -73.1, -37.75 in-in in 8.2407 Saltbr-in 2.735 HRD-in -71.3, -45.86 73.98, -5.89 in-in-none SNCiin in-none ActLoopNT-in 2.7688 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 174.81 APE8-dihe-in -59.17, 141.04 APE8-rot-na 332.8 APE67-dihe-in -80.76, -5.98 -67.68, -15.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.4769 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 B 288.0 270.0 17 31 27 4 [[521, 779], [822, 1097]] 2.0 3zep TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 3ZEPC P52333 814 1100 1124.0 1NX:2101 Type1 None DFGin 6.2667 14.2845 BLAminus -143.3, 179.56 63.59, 86.35 -106.32, 31.56 290.45, 75.82 -68.82, -32.0 in-in in 8.1744 Saltbr-in 2.7545 HRD-in -76.43, -48.0 76.34, -21.16 in-in-none SNCiin in-none ActLoopNT-in 2.7144 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 45.01 APE9-dihe-in -93.38, 161.79 APE8-dihe-in -56.5, 116.98 APE8-rot-na 326.42 APE67-dihe-in -74.98, -4.7 -72.25, -13.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.7287 APE9-dist-in 6.8497 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 C 288.0 278.0 9 31 29 2 [[521, 779], [822, 1097]] 2.0 3zep TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 3ZEPD P52333 814 1099 1124.0 1NX:2100 Type1 None DFGin 6.5755 14.572 BLAminus -134.12, 176.57 59.25, 80.73 -100.38, 28.57 291.24, 76.13 -63.83, -42.01 in-in in 8.3615 Saltbr-in 2.6719 HRD-in -72.39, -47.07 79.2, -13.88 in-in-none SNCiin in-none ActLoopNT-in 2.7779 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 161.47 APE8-dihe-in -52.69, 138.76 APE8-rot-na 329.47 APE67-dihe-in -77.9, -7.22 -77.25, -13.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.5559 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 D 288.0 274.0 12 31 28 3 [[521, 779], [822, 1097]] 2.0 3zep TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 7UYVD P52333 814 1100 1124.0 OV5:1201 Type1 None DFGin 6.4207 14.2582 BLAminus -133.29, -179.06 58.4, 83.86 -99.71, 22.65 285.23, 81.71 -62.49, -28.09 in-in in 8.2976 Saltbr-in 2.6722 HRD-in -64.99, -48.29 76.96, -0.25 in-in-none SNCiin in-none ActLoopNT-in 2.7457 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 163.98 APE8-dihe-in -58.27, 129.89 APE8-rot-na 335.93 APE67-dihe-in -80.69, -3.3 -71.81, -12.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4681 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 D 291.0 272.0 15 31 26 5 [[521, 779], [822, 1097]] 2.0 7uyv TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 5VO6A P52333 815 1099 1124.0 9J4:4000 Type1 None DFGin 6.5587 13.7482 BLAminus -128.78, -173.97 61.05, 89.09 -107.4, 19.66 285.17, 86.8 -68.24, -28.8 in-in in 7.5123 Saltbr-in 2.9107 HRD-in -75.3, -50.06 76.72, -16.95 in-in-none SNCiin in-none ActLoopNT-in 2.9825 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 135.66 APE8-rot-na 332.57 APE67-dihe-in -81.44, -5.82 -70.82, -9.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1040S,C1048S None None XRAY 2.65 0.215 0.284 A 293.0 271.0 14 31 25 6 [[521, 779], [822, 1097]] 2.0 5vo6 TYR_JAK3-2_HUMAN TYR 2.1e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6NY4A P52333 815 1099 1124.0 Z3A:4000 Type1 None DFGin 6.4319 13.7522 BLAminus -130.0, -166.41 50.15, 85.44 -100.28, 21.12 284.91, 84.56 -64.41, -23.36 in-in in 7.6903 Saltbr-in 2.7769 HRD-in -74.4, -47.07 70.71, -6.14 in-in-none SNCiin in-none ActLoopNT-in 2.8428 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -0.08 APE9-dihe-in -95.23, 160.07 APE8-dihe-in -49.81, 129.43 APE8-rot-na 333.86 APE67-dihe-in -73.45, 2.08 -64.08, -16.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.7064 APE9-dist-in 7.0951 C811S,C1040S,C1048S None None XRAY 2.33 0.216 0.241 A 293.0 277.0 8 31 27 4 [[521, 779], [822, 1097]] 2.0 6ny4 TYR_JAK3-2_HUMAN TYR 2.1e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4V0GB P52333 816 1098 1124.0 G9B:2099 Type1 None DFGin 6.202 14.6329 BLAminus -137.8, -174.69 52.03, 76.68 -96.09, 37.57 296.46, 78.81 -70.34, -40.16 in-in in 8.7004 Saltbr-in 2.629 HRD-in -75.76, -37.0 67.95, -17.09 in-in-none SNCiin in-none ActLoopNT-in 2.8243 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -54.69 APE8-rot-na 331.57 APE67-dihe-in -77.98, -0.68 -62.56, -42.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 3.0 0.254 0.295 B 283.0 274.0 9 31 26 5 [[521, 779], [822, 1097]] 2.0 4v0g TYR_JAK3-2_HUMAN TYR 2.3e-81 278.9 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4V0GA P52333 817 1098 1124.0 G9B:2099 Type1 None DFGin 6.198 14.7166 BLAminus -144.75, -176.45 39.25, 85.88 -90.52, 22.25 286.27, 74.42 -61.38, -18.98 in-in in 8.3521 Saltbr-in 2.7066 HRD-in -65.46, -44.14 69.1, 4.41 in-in-none SNCiin in-none ActLoopNT-in 2.8503 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -33.75 APE8-rot-na 330.77 APE67-dihe-in -73.45, -1.83 -68.02, -39.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 3.0 0.254 0.295 A 283.0 269.0 13 31 27 4 [[521, 779], [822, 1097]] 2.0 4v0g TYR_JAK3-2_HUMAN TYR 2.3e-81 278.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4Z16A P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.693 14.5354 BLAminus -125.11, -170.67 46.31, 83.09 -100.98, 26.25 290.17, 83.28 -67.99, -29.42 in-in in 8.3468 Saltbr-in 2.8339 HRD-in -67.29, -45.59 73.41, -19.17 in-in-none SNCiin in-none ActLoopNT-in 2.8291 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 77.57 APE8-rot-na 328.09 APE67-dihe-in -74.64, -13.67 -80.93, -12.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 A 316.0 273.0 17 31 26 5 [[521, 779], [822, 1097]] 2.0 4z16 TYR_JAK3-2_HUMAN TYR 7.5e-81 277.2 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4Z16C P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.724 14.5409 BLAminus -124.89, -171.04 46.95, 83.36 -101.0, 25.74 290.21, 83.17 -68.15, -28.94 in-in in 8.3723 Saltbr-in 2.8403 HRD-in -67.03, -45.78 73.53, -19.66 in-in-none SNCiin in-none ActLoopNT-in 2.7882 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 38.92 APE8-rot-na 335.43 APE67-dihe-in -76.63, -13.6 -68.45, -18.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 C 316.0 273.0 17 31 26 5 [[521, 779], [822, 1097]] 2.0 4z16 TYR_JAK3-2_HUMAN TYR 7.5e-81 277.2 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4Z16D P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.6883 14.5667 BLAminus -124.04, -170.5 45.94, 82.68 -99.35, 24.89 290.17, 82.54 -66.47, -27.42 in-in in 8.3931 Saltbr-in 2.8748 HRD-in -67.23, -45.45 73.09, -20.62 in-in-none SNCiin in-none ActLoopNT-in 2.7942 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 52.48 APE8-rot-na 345.61 APE67-dihe-in -77.91, -13.97 -72.79, -6.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 D 316.0 273.0 17 31 26 5 [[521, 779], [822, 1097]] 2.0 4z16 TYR_JAK3-2_HUMAN TYR 7.5e-81 277.2 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 4QPSA P52333 814 1100 1124.0 37Q:1201 Type1 None DFGin 6.8957 14.0909 BLAminus -130.94, -174.49 64.52, 86.82 -104.86, 15.71 281.27, 81.21 -57.28, -32.23 in-in in 8.5879 Saltbr-in 2.8637 HRD-in -78.56, -46.33 74.55, -53.21 in-in-none SNCiin in-none ActLoopNT-in 2.801 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 149.07 APE8-rot-na 18.94 APE67-dihe-in -69.31, -9.6 -100.11, -5.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D949A,C1040S,C1048S None None XRAY 1.8 0.21 0.251 A 293.0 270.0 17 31 25 6 [[521, 779], [822, 1097]] 2.0 4qps TYR_JAK3-2_HUMAN TYR 3.9e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6GLAA P52333 813 1103 1124.0 F4B:1201 Type1 None DFGin 6.1255 14.0661 BLAminus -126.69, -163.69 45.61, 84.37 -97.16, 18.74 276.14, 73.33 -60.39, -30.05 in-in in 7.8334 Saltbr-in 2.6744 HRD-in -80.36, -50.35 74.06, -4.7 in-in-none SNCiin in-none ActLoopNT-in 2.7495 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 115.39 APE9-dihe-in -100.65, 143.31 APE8-dihe-in -75.22, 92.35 APE8-rot-na 30.49 APE67-dihe-in -81.25, -0.82 -60.88, -31.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.6793 APE9-dist-in 7.0014 None None None XRAY 1.92 0.228 0.273 A 294.0 288.0 3 31 28 3 [[521, 779], [822, 1097]] 2.0 6gla TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6GLAB P52333 813 1103 1124.0 F4B:1201 Type1 None DFGin 6.1346 14.0372 BLAminus -126.98, -166.17 47.87, 84.06 -100.26, 19.16 275.64, 73.52 -60.46, -30.51 in-in in 7.8307 Saltbr-in 2.6702 HRD-in -83.39, -49.56 74.28, -3.93 in-in-none SNCiin in-none ActLoopNT-in 2.7748 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 114.52 APE9-dihe-in -101.31, 145.02 APE8-dihe-in -77.95, 91.55 APE8-rot-na 29.11 APE67-dihe-in -79.72, -1.04 -62.76, -29.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.7449 APE9-dist-in 6.9663 None None None XRAY 1.92 0.228 0.273 B 294.0 286.0 5 31 28 3 [[521, 779], [822, 1097]] 2.0 6gla TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6GLBA P52333 813 1103 1124.0 F48:1201 Type1 None DFGin 6.0868 14.0047 BLAminus -127.29, -165.11 42.2, 80.94 -98.99, 18.18 281.6, 72.22 -46.91, -40.63 in-in in 7.5761 Saltbr-in 2.7125 HRD-in -78.7, -52.76 77.75, 9.6 in-in-none SNCiin in-none ActLoopNT-in 2.7344 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.22 APE9-dihe-in -106.96, 151.72 APE8-dihe-in -79.63, 91.52 APE8-rot-na 32.17 APE67-dihe-in -74.91, -5.23 -62.01, -34.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.734 APE9-dist-in 6.7274 None None None XRAY 2.0 0.236 0.29 A 294.0 288.0 3 31 28 3 [[521, 779], [822, 1097]] 2.0 6glb TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 6GLBB P52333 813 1103 1124.0 F48:1201 Type1 None DFGin 6.117 14.0249 BLAminus -125.81, -165.95 42.86, 80.87 -97.87, 18.6 282.22, 74.99 -51.1, -37.8 in-in in 7.5451 Saltbr-in 2.7085 HRD-in -76.97, -51.62 77.21, 8.56 in-in-none SNCiin in-none ActLoopNT-in 2.7568 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 130.97 APE9-dihe-in -105.16, 150.45 APE8-dihe-in -79.13, 89.35 APE8-rot-na 33.14 APE67-dihe-in -76.14, -3.82 -57.76, -35.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.6293 APE9-dist-in 6.7039 None None None XRAY 2.0 0.236 0.29 B 294.0 288.0 3 31 28 3 [[521, 779], [822, 1097]] 2.0 6glb TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 9R5ZA P52333 822 1101 1124.0 A1JJU:60301 Type1 None DFGin 6.1324 14.0012 BLAminus -127.52, -161.85 48.17, 81.61 -92.0, 24.85 277.91, 73.75 -73.44, -23.7 in-in in 7.6679 Saltbr-in 2.7676 HRD-in -79.16, -47.46 79.61, -35.13 in-in-none SNCiin in-none ActLoopNT-in 2.8804 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.63 APE8-rot-na 20.77 APE67-dihe-in -76.47, -3.83 -62.4, -34.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.239 0.289 A 294.0 258.0 22 31 26 5 [[521, 779], [822, 1097]] 2.0 9r5z TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 9R5ZB P52333 816 1101 1124.0 A1JJU:60301 Type1 None DFGin 6.2264 14.1304 BLAminus -127.35, -164.41 49.32, 77.12 -91.09, 23.07 281.2, 72.28 -62.52, -23.26 in-in in 7.8816 Saltbr-in 2.8186 HRD-in -86.18, -46.89 79.27, -42.6 in-in-none SNCiin in-none ActLoopNT-in 2.8747 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 79.25 APE8-rot-na 31.77 APE67-dihe-in -82.31, -0.99 -65.94, -24.16 APE12-dist-na 11.0451 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.239 0.289 B 294.0 275.0 11 31 28 3 [[521, 779], [822, 1097]] 2.0 9r5z TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3

TYR_JAK3-2 (Tyrosine-protein kinase JAK3)

Total number of chains: 74
Active chains: 8
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 72 97.3% AF-P52333-K2A
DFGin ABAminus 2 2.7% 7C3NA

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
JAK3-2 JAK3_HUMAN AF-P52333-K2A P52333 814 1105 1124.0 No_ligand No_ligand Active DFGin 6.1026 13.7936 BLAminus -134.56, -179.19 51.31, 75.31 -82.94, 20.6 292.85, 86.33 -61.55, -30.97 in-in in 8.2483 Saltbr-in 2.6953 HRD-in -70.59, -43.72 65.57, -21.68 in-in-in SNCiii in-in ActLoopNT-in 2.8552 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.42, 123.08 APE9-dihe-in -125.57, 135.88 APE8-dihe-in -78.86, 68.83 APE8-rot-na 34.92 APE67-dihe-in -75.13, -6.36 -53.49, -31.1 APE12-dist-na 10.5223 APE11-dist-na 9.5286 APE10-dist-na 10.1849 APE9-dist-in 7.1879 None None None AF2 -1.0 1.0 1.0 A 292.0 292.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 AF-P52333-K2 Homo sapiens TYR_JAK3-2_HUMAN TYR 4.6e-81 277.9 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN AF-P52333-K4A P52333 814 1105 1124.0 No_ligand No_ligand Active DFGin 6.1108 13.7687 BLAminus -141.5, -174.59 54.28, 75.11 -88.15, 17.45 293.92, 89.95 -59.55, -34.59 in-in in 8.1169 Saltbr-in 2.6779 HRD-in -78.79, -45.55 61.88, 0.83 in-in-in SNCiii in-in ActLoopNT-in 2.8819 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.64, 120.49 APE9-dihe-in -128.67, 141.65 APE8-dihe-in -77.57, 68.42 APE8-rot-na 36.41 APE67-dihe-in -72.34, -8.01 -50.71, -34.24 APE12-dist-na 13.4854 APE11-dist-na 9.5574 APE10-dist-na 10.1649 APE9-dist-in 6.4962 None None None AF2 -1.0 1.0 1.0 A 292.0 292.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 AF-P52333-K4 Homo sapiens TYR_JAK3-2_HUMAN TYR 4.6e-81 277.9 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6AAKC P52333 814 1099 1124.0 9T6:1201 Type1 Active DFGin 6.7877 14.6346 BLAminus -114.47, 172.4 69.03, 86.81 -107.19, 29.58 286.76, 78.99 -58.47, -55.72 in-in in 8.2406 Saltbr-in 2.7237 HRD-in -89.94, -41.82 71.73, -3.81 in-in-in SNCiii in-in ActLoopNT-in 2.7832 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.85, 76.94 APE9-dihe-in -171.36, 163.86 APE8-dihe-in -58.47, 128.31 APE8-rot-na 338.62 APE67-dihe-in -73.56, -5.95 -79.88, -15.99 APE12-dist-na 12.9746 APE11-dist-na 9.2183 APE10-dist-na 10.3986 APE9-dist-in 7.7513 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.67 0.269 0.326 C 287.0 276.0 10 31 31 0 [[521, 779], [822, 1097]] 2.0 6aak Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7UYVA P52333 814 1100 1124.0 OV5:1201 Type1 Active DFGin 6.3763 14.2869 BLAminus -136.33, -178.14 60.47, 77.06 -94.46, 22.49 283.21, 76.25 -61.39, -33.76 in-in in 8.2009 Saltbr-in 2.6421 HRD-in -69.18, -41.57 72.69, -12.85 in-in-in SNCiii in-in ActLoopNT-in 2.7503 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.18, 82.75 APE9-dihe-in -112.58, 159.26 APE8-dihe-in -47.72, 129.83 APE8-rot-na 329.64 APE67-dihe-in -81.57, 1.11 -69.92, -19.01 APE12-dist-na 11.5311 APE11-dist-na 8.0482 APE10-dist-na 11.6832 APE9-dist-in 7.3388 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 A 291.0 278.0 9 31 31 0 [[521, 779], [822, 1097]] 2.0 7uyv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7UYVB P52333 814 1100 1124.0 OV5:1201 Type1 Active DFGin 6.2251 14.2162 BLAminus -136.69, -173.44 56.56, 80.52 -96.27, 21.5 284.08, 77.64 -57.68, -39.3 in-in in 8.1504 Saltbr-in 2.6309 HRD-in -80.27, -44.25 68.81, -0.6 in-in-in SNCiii in-in ActLoopNT-in 2.7556 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.34, 85.59 APE9-dihe-in -127.16, 148.54 APE8-dihe-in -37.53, 121.21 APE8-rot-na 325.53 APE67-dihe-in -80.04, -3.68 -72.05, -16.34 APE12-dist-na 11.5779 APE11-dist-na 9.1429 APE10-dist-na 12.2547 APE9-dist-in 7.3873 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 B 291.0 284.0 3 31 31 0 [[521, 779], [822, 1097]] 2.0 7uyv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 3PJCA P52333 815 1104 1124.0 PJC:800 Type1 Active DFGin 6.6986 14.412 BLAminus -131.65, -174.74 53.97, 85.79 -100.88, 20.12 280.65, 74.1 -60.63, -24.35 in-in in 8.6962 Saltbr-in 2.6139 HRD-in -69.63, -48.63 77.02, -5.32 in-in-in SNCiii in-in ActLoopNT-in 2.8226 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.16, 145.45 APE9-dihe-in -115.3, 150.0 APE8-dihe-in -81.75, 75.29 APE8-rot-na 32.65 APE67-dihe-in -79.59, -4.38 -53.88, -28.84 APE12-dist-na 13.2005 APE11-dist-na 11.5918 APE10-dist-na 12.7974 APE9-dist-in 7.9845 None None None XRAY 2.2 0.182 0.215 A 315.0 286.0 4 31 31 0 [[521, 779], [822, 1097]] 2.0 3pjc Homo sapiens TYR_JAK3-2_HUMAN TYR 6.1e-81 277.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6GL9A P52333 812 1103 1124.0 F3W:1201 Type1 Active DFGin 6.2475 14.0115 BLAminus -125.6, -168.17 49.24, 81.71 -98.97, 21.2 279.85, 75.03 -60.06, -26.17 in-in in 7.7934 Saltbr-in 2.6834 HRD-in -78.49, -49.26 75.45, 0.4 in-in-in SNCiii in-in ActLoopNT-in 2.7882 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.67, 117.53 APE9-dihe-in -98.8, 151.13 APE8-dihe-in -79.69, 90.74 APE8-rot-na 31.23 APE67-dihe-in -78.37, -0.16 -59.8, -32.45 APE12-dist-na 9.3301 APE11-dist-na 10.7633 APE10-dist-na 11.753 APE9-dist-in 6.9787 None None None XRAY 1.7 0.209 0.244 A 294.0 292.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 6gl9 Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6GL9B P52333 813 1103 1124.0 F3W:1201 Type1 Active DFGin 6.21 14.019 BLAminus -123.31, -164.34 42.61, 83.03 -97.02, 22.96 280.36, 70.4 -63.87, -26.0 in-in in 7.7595 Saltbr-in 2.667 HRD-in -78.77, -47.46 73.56, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.7746 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.72, 116.63 APE9-dihe-in -97.44, 150.89 APE8-dihe-in -77.79, 91.0 APE8-rot-na 32.15 APE67-dihe-in -73.22, -2.71 -60.01, -35.33 APE12-dist-na 9.3264 APE11-dist-na 10.7827 APE10-dist-na 11.7277 APE9-dist-in 6.9767 None None None XRAY 1.7 0.209 0.244 B 294.0 291.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 6gl9 Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7C3NA P52333 814 1102 1124.0 FHX:9000 Type1 Inactive DFGin 6.068 13.3862 ABAminus -140.24, 14.21 -145.02, 134.62 -131.29, 32.79 294.67, 80.18 -64.88, -27.68 in-in in 8.233 Saltbr-in 2.7822 HRD-in -78.6, -47.11 71.84, 1.59 in-in-in SNCiii in-in ActLoopNT-in 2.8064 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.04, 126.4 APE9-dihe-in -81.7, 145.46 APE8-dihe-in -77.41, 71.31 APE8-rot-na 31.38 APE67-dihe-in -79.88, -2.49 -60.07, -26.59 APE12-dist-na 11.7358 APE11-dist-na 10.4538 APE10-dist-na 12.3096 APE9-dist-in 7.2655 None PTR980,PTR981 PTR980,PTR981 XRAY 1.98 0.17 0.194 A 315.0 289.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 7c3n Homo sapiens TYR_JAK3-2_HUMAN TYR 6.1e-81 277.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 3LXKA P52333 815 1098 1124.0 MI1:1125 Type1 Inactive DFGin 6.0647 13.0171 ABAminus -128.16, 7.24 -148.97, 145.15 -138.77, 31.19 300.52, 88.17 -60.03, -27.75 in-in in 8.251 Saltbr-in 2.7565 HRD-in -78.64, -46.72 70.97, -5.63 in-in-out SNCiio in-out ActLoopNT-in 2.8402 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.3, 17.09 APE9-dihe-in -92.59, 156.17 APE8-dihe-in -54.3, 131.46 APE8-rot-na 335.17 APE67-dihe-in -82.42, -7.27 -71.07, -8.83 APE12-dist-na 14.2685 APE11-dist-na 9.9216 APE10-dist-na 10.5049 APE9-dist-in 7.209 C1048S None None XRAY 2.0 0.205 0.265 A 327.0 279.0 5 31 31 0 [[521, 779], [822, 1097]] 2.0 3lxk Homo sapiens TYR_JAK3-2_HUMAN TYR 3.2e-81 278.4 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5W86A P52333 814 1098 1124.0 9YV:4000 Type1 Inactive DFGin 6.508 14.2333 BLAminus -130.78, -178.04 55.33, 86.29 -99.45, 24.99 285.64, 80.91 -59.45, -36.09 in-in in 8.3613 Saltbr-in 2.7197 HRD-in -61.74, -49.91 79.02, -19.05 in-in-out SNCiio in-out ActLoopNT-in 2.8338 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -62.63 APE8-dihe-in -73.09, 69.06 APE8-rot-na 28.5 APE67-dihe-in -76.22, -6.14 -68.16, -24.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3257 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 A 287.0 271.0 14 31 26 5 [[521, 779], [822, 1097]] 2.0 5w86 Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5W86D P52333 814 1099 1124.0 9YV:4000 Type1 Inactive DFGin 6.5614 14.2551 BLAminus -130.88, -178.77 56.18, 85.97 -99.02, 25.19 285.73, 80.24 -59.91, -34.36 in-in in 8.1827 Saltbr-in 2.7569 HRD-in -62.59, -49.55 78.85, -19.41 in-in-out SNCiio in-out ActLoopNT-in 2.814 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -64.08 APE8-dihe-in -73.59, 57.74 APE8-rot-na 27.09 APE67-dihe-in -73.08, -10.82 -59.31, -28.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2414 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 D 287.0 274.0 12 31 26 5 [[521, 779], [822, 1097]] 2.0 5w86 Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6AAKA P52333 815 1098 1124.0 9T6:1201 Type1 Inactive DFGin 6.4258 14.4877 BLAminus -141.28, -175.48 60.31, 80.99 -97.75, 30.98 284.74, 77.33 -61.02, -46.05 in-in in 8.5254 Saltbr-in 2.67 HRD-in -75.62, -45.99 77.6, -18.1 in-in-out SNCiio in-out ActLoopNT-in 2.7362 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.2, -11.07 APE9-dihe-in -68.95, 155.07 APE8-dihe-in -47.57, 131.1 APE8-rot-na 329.72 APE67-dihe-in -73.4, -26.9 -66.76, -22.48 APE12-dist-na 11.9929 APE11-dist-na 8.6734 APE10-dist-na 11.3981 APE9-dist-in 7.4704 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.67 0.269 0.326 A 287.0 277.0 7 31 31 0 [[521, 779], [822, 1097]] 2.0 6aak Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6AAKB P52333 815 1100 1124.0 9T6:1201 Type1 Inactive DFGin 6.549 14.3135 BLAminus -132.57, -171.05 56.03, 83.09 -98.42, 24.6 281.38, 75.24 -63.47, -40.11 in-in in 8.0358 Saltbr-in 2.7546 HRD-in -65.5, -48.18 78.33, -13.38 in-in-out SNCiio in-out ActLoopNT-in 2.9074 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.61, -28.55 APE9-dihe-in -64.46, 151.35 APE8-dihe-in -40.19, 130.42 APE8-rot-na 326.93 APE67-dihe-in -77.17, -14.56 -72.74, -10.57 APE12-dist-na 13.1081 APE11-dist-na 9.526 APE10-dist-na 10.0845 APE9-dist-in 7.2029 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.67 0.269 0.326 B 287.0 285.0 1 31 31 0 [[521, 779], [822, 1097]] 2.0 6aak Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 3ZC6A P52333 814 1100 1124.0 VFC:2103 Type1 Inactive DFGin 6.3992 14.249 BLAminus -132.73, -176.21 56.45, 83.25 -97.56, 22.77 285.82, 73.7 -62.6, -27.55 in-in in 8.2919 Saltbr-in 2.8022 HRD-in -72.44, -47.03 73.15, -6.89 in-in-out SNCiio in-out ActLoopNT-in 2.7419 ActLoopCT-out TYR APEdihe_noiai APEdist_aaai APE10-dihe-none 999.0, 118.21 APE9-dihe-out -83.58, -179.01 APE8-dihe-in -60.9, 137.23 APE8-rot-na 332.96 APE67-dihe-in -76.45, -9.26 -65.3, -16.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.5354 APE9-dist-in 5.9074 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 A 288.0 279.0 8 31 27 4 [[521, 779], [822, 1097]] 2.0 3zc6 Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 3ZC6C P52333 814 1100 1124.0 VFC:2103 Type1 Inactive DFGin 6.2807 14.0027 BLAminus -123.64, -177.74 61.16, 80.91 -97.9, 27.04 288.23, 77.53 -66.72, -26.1 in-in in 8.1905 Saltbr-in 2.6842 HRD-in -72.21, -46.31 77.05, -24.4 in-in-out SNCiio in-out ActLoopNT-in 2.7606 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.85 APE8-dihe-in -77.18, 80.1 APE8-rot-na 33.09 APE67-dihe-in -76.9, -10.93 -67.13, -29.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1774 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 C 288.0 277.0 10 31 27 4 [[521, 779], [822, 1097]] 2.0 3zc6 Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 3ZEPA P52333 814 1098 1124.0 1NX:2099 Type1 Inactive DFGin 6.4201 14.3445 BLAminus -139.2, 179.6 58.57, 83.63 -103.43, 28.82 290.46, 79.48 -67.26, -39.4 in-in in 8.1983 Saltbr-in 2.7236 HRD-in -72.97, -44.84 72.81, -0.01 in-in-out SNCiio in-out ActLoopNT-in 2.7642 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -90.83, 0.53 APE9-dihe-in -141.71, 168.37 APE8-dihe-in -61.5, 133.7 APE8-rot-na 333.46 APE67-dihe-in -72.33, -1.68 -64.6, -21.71 APE12-dist-na 13.4306 APE11-dist-na 10.6555 APE10-dist-na 6.8245 APE9-dist-in 6.4001 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 A 288.0 276.0 9 31 31 0 [[521, 779], [822, 1097]] 2.0 3zep Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7UYVC P52333 812 1100 1124.0 OV5:1201 Type1 Inactive DFGin 6.5497 14.2474 BLAminus -139.0, -178.89 62.41, 84.96 -102.47, 24.54 285.05, 80.61 -63.66, -34.31 in-in in 8.1764 Saltbr-in 2.7239 HRD-in -72.48, -47.02 76.02, -14.38 in-in-out SNCiio in-out ActLoopNT-in 2.6962 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -72.04, 75.71 APE9-dihe-in -159.34, 174.75 APE8-dihe-in -55.7, 114.03 APE8-rot-na 331.85 APE67-dihe-in -81.89, -1.84 -68.05, -12.84 APE12-dist-na 12.9994 APE11-dist-na 8.9457 APE10-dist-na 10.9307 APE9-dist-out 8.0032 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 C 291.0 281.0 8 31 31 0 [[521, 779], [822, 1097]] 2.0 7uyv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4RIOA P52333 815 1099 1124.0 3QX:4000 Type1 Inactive DFGin 6.3935 13.5705 BLAminus -146.26, -172.55 60.58, 82.0 -101.14, 19.19 286.89, 85.95 -65.85, -24.53 in-in in 7.6666 Saltbr-in 2.8105 HRD-in -70.94, -43.53 62.59, 2.86 in-in-out SNCiio in-out ActLoopNT-in 2.9783 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -135.63, 27.38 APE9-dihe-in -118.75, 159.28 APE8-dihe-in -55.16, 127.94 APE8-rot-na 333.58 APE67-dihe-in -76.1, -3.72 -64.2, -13.91 APE12-dist-na 12.5847 APE11-dist-na 9.8864 APE10-dist-na 9.9276 APE9-dist-in 7.1524 C811S,C1040S,C1048S None None XRAY 2.69 0.218 0.281 A 293.0 285.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 4rio Homo sapiens TYR_JAK3-2_HUMAN TYR 2.1e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5WFJA P52333 817 1099 1124.0 9Z4:4000 Type1 Inactive DFGin 6.5811 13.8338 BLAminus -136.44, -170.83 58.73, 75.78 -96.48, 23.06 286.97, 86.34 -64.05, -24.53 in-in in 7.6299 Saltbr-in 2.8738 HRD-in -76.6, -46.72 68.06, 1.53 in-in-out SNCiio in-out ActLoopNT-in 2.9182 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.32, 20.43 APE9-dihe-in -103.33, 153.28 APE8-dihe-in -50.05, 126.35 APE8-rot-na 333.7 APE67-dihe-in -76.71, 0.96 -65.58, -12.14 APE12-dist-na 13.631 APE11-dist-na 9.8634 APE10-dist-na 10.1142 APE9-dist-in 7.0412 C811S,C1040S,C1048S None None XRAY 2.48 0.205 0.255 A 293.0 265.0 18 31 29 2 [[521, 779], [822, 1097]] 2.0 5wfj Homo sapiens TYR_JAK3-2_HUMAN TYR 2.1e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4HVDA P52333 815 1101 1124.0 933:1202 Type1 Inactive DFGin 6.5272 14.0171 BLAminus -128.55, -166.42 58.39, 76.56 -98.5, 22.97 288.27, 78.76 -65.56, -24.6 in-in in 8.047 Saltbr-in 2.8425 HRD-in -70.62, -50.61 83.01, -13.8 in-in-out SNCiio in-out ActLoopNT-in 2.8441 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -120.35, 6.88 APE9-dihe-in -87.79, 153.51 APE8-dihe-in -47.35, 128.71 APE8-rot-na 328.03 APE67-dihe-in -81.29, -0.66 -70.05, -11.78 APE12-dist-na 13.6702 APE11-dist-na 9.8379 APE10-dist-na 10.1082 APE9-dist-in 7.3252 C1040S,C1048S None None XRAY 1.85 0.225 0.259 A 314.0 276.0 11 31 31 0 [[521, 779], [822, 1097]] 2.0 4hvd Homo sapiens TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4HVGA P52333 814 1103 1124.0 19Q:1201 Type1 Inactive DFGin 6.3691 14.0706 BLAminus -130.41, -171.25 53.38, 75.08 -85.23, 20.51 289.87, 75.57 -58.89, -29.62 in-in in 8.256 Saltbr-in 2.8006 HRD-in -81.72, -46.13 83.55, -16.25 in-in-out SNCiio in-out ActLoopNT-in 2.9723 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -135.6, 18.04 APE9-dihe-in -102.46, 155.94 APE8-dihe-in -50.03, 129.65 APE8-rot-na 326.24 APE67-dihe-in -77.88, -2.28 -61.37, -21.51 APE12-dist-na 13.6391 APE11-dist-na 9.8591 APE10-dist-na 10.1069 APE9-dist-in 7.4421 C1040S,C1048S None None XRAY 2.75 0.214 0.274 A 314.0 281.0 9 31 31 0 [[521, 779], [822, 1097]] 2.0 4hvg Homo sapiens TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4HVHA P52333 814 1102 1124.0 19R:1201 Type1 Inactive DFGin 6.4361 14.1039 BLAminus -140.81, -174.18 54.94, 86.96 -103.32, 27.47 289.17, 75.35 -59.86, -26.99 in-in in 8.1031 Saltbr-in 2.73 HRD-in -70.65, -47.69 79.95, -7.3 in-in-out SNCiio in-out ActLoopNT-in 2.8656 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -125.66, 18.79 APE9-dihe-in -103.72, 157.23 APE8-dihe-in -46.25, 127.99 APE8-rot-na 329.23 APE67-dihe-in -82.32, 1.96 -65.92, -16.55 APE12-dist-na 13.6054 APE11-dist-na 9.7978 APE10-dist-na 10.0657 APE9-dist-in 7.3949 C1040S,C1048S None None XRAY 2.3 0.23 0.283 A 314.0 278.0 11 31 31 0 [[521, 779], [822, 1097]] 2.0 4hvh Homo sapiens TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4HVIA P52333 815 1101 1124.0 19S:1201 Type1 Inactive DFGin 6.4427 13.9006 BLAminus -133.13, -169.35 58.25, 80.79 -103.46, 21.02 290.11, 82.66 -64.8, -24.06 in-in in 8.1481 Saltbr-in 2.7134 HRD-in -70.83, -44.69 73.14, -9.21 in-in-out SNCiio in-out ActLoopNT-in 3.0118 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.42, 8.91 APE9-dihe-in -93.49, 161.0 APE8-dihe-in -50.05, 128.83 APE8-rot-na 327.89 APE67-dihe-in -77.81, -4.37 -61.08, -19.7 APE12-dist-na 13.3068 APE11-dist-na 9.5384 APE10-dist-na 9.8434 APE9-dist-in 7.267 C1040S,C1048S None None XRAY 2.4 0.238 0.303 A 314.0 274.0 13 31 31 0 [[521, 779], [822, 1097]] 2.0 4hvi Homo sapiens TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4I6QA P52333 815 1102 1124.0 1DT:1202 Type1 Inactive DFGin 6.5477 13.8797 BLAminus -122.27, -166.37 58.65, 80.25 -102.66, 18.99 282.73, 92.38 -63.16, -27.69 in-in in 8.1701 Saltbr-in 2.6678 HRD-in -82.65, -46.76 80.12, -11.61 in-in-out SNCiio in-out ActLoopNT-in 2.8258 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.82, 1.26 APE9-dihe-in -88.25, 159.4 APE8-dihe-in -50.29, 130.77 APE8-rot-na 324.04 APE67-dihe-in -86.64, 4.17 -68.93, -13.66 APE12-dist-na 13.7233 APE11-dist-na 9.8721 APE10-dist-na 9.9493 APE9-dist-in 7.3231 C1040S,C1048S None None XRAY 1.85 0.198 0.245 A 314.0 277.0 11 31 31 0 [[521, 779], [822, 1097]] 2.0 4i6q Homo sapiens TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4QT1A P52333 814 1102 1124.0 3C9:1201 Type1 Inactive DFGin 6.6492 13.9762 BLAminus -139.02, 177.24 52.6, 80.83 -91.99, 24.19 292.74, 76.91 -57.05, -27.61 in-in in 7.854 Saltbr-in 2.8081 HRD-in -76.1, -42.64 74.06, 0.56 in-in-out SNCiio in-out ActLoopNT-in 2.8439 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.55, 16.0 APE9-dihe-in -104.71, 155.27 APE8-dihe-in -51.8, 130.25 APE8-rot-na 330.69 APE67-dihe-in -80.61, -3.03 -68.8, -13.83 APE12-dist-na 13.5093 APE11-dist-na 9.8141 APE10-dist-na 9.9829 APE9-dist-in 7.1611 C1040S,C1048S None None XRAY 2.4 0.21 0.273 A 314.0 277.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 4qt1 Homo sapiens TYR_JAK3-2_HUMAN TYR 2.7e-81 278.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5TOZA P52333 815 1100 1124.0 7H4:1201 Type1 Inactive DFGin 6.4346 14.1797 BLAminus -132.42, -172.67 55.17, 83.47 -97.89, 23.39 288.4, 75.31 -59.42, -27.52 in-in in 8.0531 Saltbr-in 2.7698 HRD-in -70.7, -45.74 70.21, -7.3 in-in-out SNCiio in-out ActLoopNT-in 2.8052 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.82, 11.45 APE9-dihe-in -93.23, 156.46 APE8-dihe-in -46.82, 125.7 APE8-rot-na 327.47 APE67-dihe-in -74.64, -1.89 -65.68, -15.53 APE12-dist-na 13.7154 APE11-dist-na 9.6672 APE10-dist-na 10.1541 APE9-dist-in 7.336 None None None XRAY 1.98 0.184 0.215 A 321.0 278.0 8 31 31 0 [[521, 779], [822, 1097]] 2.0 5toz Homo sapiens TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5TTSA P52333 814 1100 1124.0 7KU:4000 Type1 Inactive DFGin 6.4256 14.158 BLAminus -129.0, -169.11 47.63, 82.34 -97.79, 20.5 281.57, 83.57 -59.54, -22.32 in-in in 7.8793 Saltbr-in 2.727 HRD-in -71.68, -45.64 72.69, -11.39 in-in-out SNCiio in-out ActLoopNT-in 2.8295 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -120.94, 5.03 APE9-dihe-in -92.95, 155.15 APE8-dihe-in -50.68, 128.91 APE8-rot-na 333.75 APE67-dihe-in -73.89, 0.34 -64.16, -15.93 APE12-dist-na 13.6385 APE11-dist-na 9.8268 APE10-dist-na 9.9629 APE9-dist-in 7.3964 C1048S None None XRAY 2.34 0.205 0.263 A 321.0 274.0 13 31 31 0 [[521, 779], [822, 1097]] 2.0 5tts Homo sapiens TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5TTUA P52333 815 1099 1124.0 7KV:1201 Type1 Inactive DFGin 6.5073 14.2203 BLAminus -134.44, -163.93 59.24, 64.07 -87.63, 14.18 281.02, 85.09 -61.33, -21.77 in-in in 8.1783 Saltbr-in 2.6873 HRD-in -74.44, -46.15 74.73, -11.09 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.51, 0.99 APE9-dihe-in -84.97, 156.58 APE8-dihe-in -52.23, 128.18 APE8-rot-na 331.46 APE67-dihe-in -73.87, -5.17 -63.29, -14.0 APE12-dist-na 13.6239 APE11-dist-na 9.6774 APE10-dist-na 9.9919 APE9-dist-in 7.2843 C1048S None None XRAY 1.72 0.193 0.212 A 321.0 271.0 14 31 31 0 [[521, 779], [822, 1097]] 2.0 5ttu Homo sapiens TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5TTVA P52333 814 1100 1124.0 7KX:4000 Type1 Inactive DFGin 6.389 13.9545 BLAminus -134.13, -173.38 47.72, 81.12 -99.64, 24.47 284.98, 81.27 -61.89, -30.49 in-in in 7.571 Saltbr-in 2.7566 HRD-in -68.58, -49.94 77.2, -11.61 in-in-out SNCiio in-out ActLoopNT-in 2.887 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.83, -8.71 APE9-dihe-in -81.68, 166.25 APE8-dihe-in -54.83, 134.34 APE8-rot-na 333.98 APE67-dihe-in -68.58, -14.21 -64.91, -25.89 APE12-dist-na 13.454 APE11-dist-na 10.1045 APE10-dist-na 9.8444 APE9-dist-in 7.0476 C1048S None None XRAY 1.93 0.195 0.25 A 321.0 280.0 7 31 31 0 [[521, 779], [822, 1097]] 2.0 5ttv Homo sapiens TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6DA4A P52333 815 1099 1124.0 G4V:1201 Type1 Inactive DFGin 6.3399 14.1592 BLAminus -125.34, -166.51 46.1, 93.47 -106.56, 19.65 286.03, 81.95 -61.5, -24.21 in-in in 8.0349 Saltbr-in 2.8116 HRD-in -66.39, -43.11 68.24, -5.72 in-in-out SNCiio in-out ActLoopNT-in 2.8446 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -76.16, 17.06 APE9-dihe-in -99.01, 151.3 APE8-dihe-in -54.06, 116.09 APE8-rot-na 335.02 APE67-dihe-in -66.76, -9.61 -46.02, -19.91 APE12-dist-na 13.2424 APE11-dist-na 9.376 APE10-dist-na 10.3711 APE9-dist-in 7.2615 C1048S None None XRAY 2.9 0.229 0.263 A 321.0 281.0 4 31 31 0 [[521, 779], [822, 1097]] 2.0 6da4 Homo sapiens TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6DB3A P52333 814 1100 1124.0 G54:4000 Type1 Inactive DFGin 6.286 13.9012 BLAminus -131.89, -177.11 58.86, 88.06 -99.15, 20.97 289.91, 81.31 -57.3, -32.4 in-in in 8.2338 Saltbr-in 2.6892 HRD-in -69.32, -44.77 72.88, -9.11 in-in-out SNCiio in-out ActLoopNT-in 2.7455 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.94, 10.67 APE9-dihe-in -91.58, 152.91 APE8-dihe-in -48.92, 124.78 APE8-rot-na 329.3 APE67-dihe-in -70.97, -6.33 -60.73, -15.87 APE12-dist-na 13.7116 APE11-dist-na 9.5497 APE10-dist-na 10.1421 APE9-dist-in 7.3914 C1048S None None XRAY 1.97 0.19 0.224 A 321.0 275.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 6db3 Homo sapiens TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6DB4A P52333 814 1100 1124.0 G4Y:4000 Type1 Inactive DFGin 6.3293 13.8866 BLAminus -129.96, -177.19 65.04, 85.51 -102.45, 21.04 283.09, 83.98 -63.09, -23.83 in-in in 8.1031 Saltbr-in 2.6779 HRD-in -75.95, -47.04 72.28, -5.11 in-in-out SNCiio in-out ActLoopNT-in 2.844 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.18, 10.26 APE9-dihe-in -87.73, 153.8 APE8-dihe-in -51.18, 129.01 APE8-rot-na 329.23 APE67-dihe-in -72.48, -3.98 -65.43, -15.27 APE12-dist-na 14.0574 APE11-dist-na 9.8642 APE10-dist-na 10.2997 APE9-dist-in 7.1511 C1048S None None XRAY 1.662 0.187 0.216 A 321.0 276.0 11 31 31 0 [[521, 779], [822, 1097]] 2.0 6db4 Homo sapiens TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6DUDA P52333 814 1100 1124.0 HB4:1201 Type1 Inactive DFGin 6.3774 14.08 BLAminus -130.37, -174.96 58.79, 79.77 -94.85, 21.4 284.9, 80.47 -61.75, -24.01 in-in in 7.8751 Saltbr-in 2.7643 HRD-in -71.12, -48.96 73.72, -5.63 in-in-out SNCiio in-out ActLoopNT-in 2.844 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -109.73, 7.91 APE9-dihe-in -89.0, 155.98 APE8-dihe-in -50.13, 125.96 APE8-rot-na 330.56 APE67-dihe-in -75.78, -4.72 -64.96, -12.29 APE12-dist-na 14.024 APE11-dist-na 9.7788 APE10-dist-na 10.0218 APE9-dist-in 7.0938 C1048S None None XRAY 1.66 0.185 0.215 A 321.0 272.0 15 31 31 0 [[521, 779], [822, 1097]] 2.0 6dud Homo sapiens TYR_JAK3-2_HUMAN TYR 3e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7Q6HAAA P52333 814 1100 1124.0 934:1201 Type1 Inactive DFGin 6.4415 13.9124 BLAminus -128.11, -171.29 67.58, 71.88 -97.45, 20.62 287.7, 81.42 -64.43, -23.85 in-in in 7.9084 Saltbr-in 2.684 HRD-in -72.1, -52.28 82.4, -12.01 in-in-out SNCiio in-out ActLoopNT-in 2.789 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.93, 11.02 APE9-dihe-in -86.89, 152.23 APE8-dihe-in -44.63, 129.97 APE8-rot-na 328.93 APE67-dihe-in -80.65, 0.41 -70.73, -15.65 APE12-dist-na 13.7773 APE11-dist-na 9.7373 APE10-dist-na 10.3425 APE9-dist-in 7.2322 None None None XRAY 1.749 0.185 0.22 AAA 327.0 282.0 5 31 31 0 [[521, 779], [822, 1097]] 2.0 7q6h Homo sapiens TYR_JAK3-2_HUMAN TYR 3.1e-81 278.5 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 3LXLA P52333 814 1098 1124.0 IZA:1 Type1 Inactive DFGin 6.3563 13.9832 BLAminus -131.21, -163.1 63.94, 61.73 -90.52, 13.42 287.27, 88.72 -63.24, -20.77 in-in in 7.8734 Saltbr-in 2.759 HRD-in -76.94, -49.02 80.12, -11.64 in-in-out SNCiio in-out ActLoopNT-in 2.8049 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -131.67, 15.09 APE9-dihe-in -90.67, 156.23 APE8-dihe-in -48.41, 132.69 APE8-rot-na 328.44 APE67-dihe-in -80.87, -3.57 -71.39, -11.92 APE12-dist-na 13.8943 APE11-dist-na 9.8069 APE10-dist-na 10.408 APE9-dist-in 7.3708 C1048S None None XRAY 1.74 0.195 0.227 A 327.0 281.0 4 31 31 0 [[521, 779], [822, 1097]] 2.0 3lxl Homo sapiens TYR_JAK3-2_HUMAN TYR 3.2e-81 278.4 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 1YVJA P52333 814 1103 1124.0 4ST:2000 Type1 Inactive DFGin 6.5054 14.0048 BLAminus -117.35, -176.34 48.83, 98.04 -113.48, 29.61 287.79, 84.73 -71.88, -20.61 in-in in 8.6181 Saltbr-in 2.8369 HRD-in -75.54, -39.16 74.88, -34.81 in-in-out SNCiio in-out ActLoopNT-in 2.8318 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.81, -5.63 APE9-dihe-in -95.15, 159.49 APE8-dihe-in -47.0, 152.52 APE8-rot-na 325.56 APE67-dihe-in -77.97, 4.18 -53.16, -16.76 APE12-dist-na 9.8059 APE11-dist-na 6.854 APE10-dist-na 8.7777 APE9-dist-out 8.1995 None PTR980,PTR981 PTR980,PTR981 XRAY 2.55 0.204 0.254 A 290.0 290.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 1yvj Homo sapiens TYR_JAK3-2_HUMAN TYR 5.4e-81 277.7 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4Z16B P52333 814 1103 1124.0 4LH:2000 Type1 Inactive DFGin 6.6659 14.5322 BLAminus -124.7, -170.19 45.77, 83.37 -100.74, 26.17 289.95, 82.89 -68.35, -28.49 in-in in 8.3877 Saltbr-in 2.8503 HRD-in -66.49, -45.94 73.56, -20.74 in-in-out SNCiio in-out ActLoopNT-in 2.8618 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -56.65, -6.62 APE9-dihe-in -78.46, 132.64 APE8-dihe-in -45.17, 131.02 APE8-rot-na 5.36 APE67-dihe-in -79.95, -14.25 -79.37, 1.19 APE12-dist-na 12.5366 APE11-dist-na 9.232 APE10-dist-na 10.615 APE9-dist-in 7.017 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 B 316.0 278.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 4z16 Homo sapiens TYR_JAK3-2_HUMAN TYR 7.5e-81 277.2 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4QPSC P52333 814 1102 1124.0 37Q:1201 Type1 Inactive DFGin 6.7747 14.2003 BLAminus -137.32, -176.14 60.46, 91.64 -108.44, 19.09 284.35, 76.96 -56.92, -26.19 in-in in 8.5021 Saltbr-in 2.8029 HRD-in -82.86, -44.58 73.92, -46.68 in-in-out SNCiio in-out ActLoopNT-in 2.8214 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.79 APE8-dihe-in -74.25, 110.88 APE8-rot-na 352.69 APE67-dihe-in -70.61, -6.19 -68.78, -23.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.9914 D949A,C1040S,C1048S None None XRAY 1.8 0.21 0.251 C 293.0 276.0 13 31 26 5 [[521, 779], [822, 1097]] 2.0 4qps Homo sapiens TYR_JAK3-2_HUMAN TYR 3.9e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5LWMA P52333 814 1103 1124.0 79T:1201 Type1 Inactive DFGin 6.1807 14.0847 BLAminus -127.82, -164.11 50.78, 78.32 -96.87, 23.57 279.03, 70.69 -64.42, -25.51 in-in in 7.8434 Saltbr-in 2.7715 HRD-in -83.79, -41.29 73.45, -47.71 in-in-out SNCiio in-out ActLoopNT-in 2.8732 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -137.31, 98.87 APE9-dihe-in -108.79, 137.75 APE8-dihe-in -66.78, 85.64 APE8-rot-na 29.56 APE67-dihe-in -76.19, -3.82 -62.47, -28.25 APE12-dist-na 10.173 APE11-dist-na 13.4615 APE10-dist-na 12.5843 APE9-dist-out 8.869 None None None XRAY 1.55 0.166 0.204 A 294.0 290.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 5lwm Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7APFA P52333 814 1103 1124.0 RQZ:1201 Type1 Inactive DFGin 6.1423 14.108 BLAminus -125.02, -164.76 52.74, 82.07 -99.72, 24.14 279.87, 69.9 -58.8, -33.19 in-in in 8.0164 Saltbr-in 2.735 HRD-in -77.19, -45.73 75.08, -49.11 in-in-out SNCiio in-out ActLoopNT-in 2.8014 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -141.26, 128.28 APE9-dihe-in -143.67, 157.99 APE8-dihe-in -81.92, 93.49 APE8-rot-na 7.76 APE67-dihe-in -79.55, -5.28 -69.3, -23.78 APE12-dist-na 10.1511 APE11-dist-na 13.6863 APE10-dist-na 13.2698 APE9-dist-out 9.0224 None None None XRAY 1.95 0.206 0.255 A 294.0 290.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 7apf Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7APFB P52333 814 1103 1124.0 RQZ:1201 Type1 Inactive DFGin 6.2636 13.9552 BLAminus -125.48, -163.38 48.35, 84.73 -99.0, 25.48 280.41, 70.13 -63.69, -28.85 in-in in 8.0989 Saltbr-in 2.7319 HRD-in -80.63, -44.7 74.93, -48.31 in-in-out SNCiio in-out ActLoopNT-in 2.7771 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -141.78, 126.08 APE9-dihe-in -146.46, 155.19 APE8-dihe-in -90.31, 98.72 APE8-rot-na 9.96 APE67-dihe-in -78.0, -2.22 -75.31, -23.81 APE12-dist-na 9.6188 APE11-dist-na 13.0285 APE10-dist-na 12.5423 APE9-dist-out 9.1313 None None None XRAY 1.95 0.206 0.255 B 294.0 285.0 5 31 31 0 [[521, 779], [822, 1097]] 2.0 7apf Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7APGA P52333 813 1103 1124.0 RQT:61201 Type1 Inactive DFGin 6.0309 13.9524 BLAminus -145.19, -172.66 53.39, 85.17 -97.7, 25.99 284.4, 73.93 -62.87, -25.47 in-in in 8.4915 Saltbr-in 3.0886 HRD-in -83.97, -50.23 79.99, -46.84 in-in-out SNCiio in-out ActLoopNT-in 2.9125 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -120.14, 50.45 APE9-dihe-in -76.86, 156.83 APE8-dihe-in -73.67, 136.77 APE8-rot-na 351.29 APE67-dihe-in -81.27, -2.59 -94.73, -13.37 APE12-dist-na 10.6785 APE11-dist-na 10.8995 APE10-dist-na 13.6012 APE9-dist-out 8.9847 None None None XRAY 2.4 0.214 0.256 A 294.0 279.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 7apg Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7APGB P52333 814 1103 1124.0 RQT:61201 Type1 Inactive DFGin 6.0387 14.0695 BLAminus -144.05, -171.58 55.33, 84.79 -97.11, 25.47 284.03, 75.74 -64.12, -25.92 in-in in 8.44 Saltbr-in 3.0791 HRD-in -83.8, -49.69 80.24, -45.58 in-in-out SNCiio in-out ActLoopNT-in 2.9057 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -121.16, 48.46 APE9-dihe-in -74.89, 156.25 APE8-dihe-in -72.87, 137.28 APE8-rot-na 354.01 APE67-dihe-in -82.99, -1.84 -93.81, -9.25 APE12-dist-na 10.8058 APE11-dist-na 10.8121 APE10-dist-na 13.4192 APE9-dist-out 8.9175 None None None XRAY 2.4 0.214 0.256 B 294.0 278.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 7apg Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7APGC P52333 812 1103 1124.0 RQT:61201 Type1 Inactive DFGin 6.0574 14.0501 BLAminus -143.35, -172.89 56.23, 84.96 -97.07, 24.64 284.44, 74.77 -64.51, -25.55 in-in in 8.468 Saltbr-in 3.0668 HRD-in -82.68, -50.65 80.68, -46.32 in-in-out SNCiio in-out ActLoopNT-in 2.9124 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -120.01, 55.65 APE9-dihe-in -74.89, 157.1 APE8-dihe-in -74.45, 136.81 APE8-rot-na 351.06 APE67-dihe-in -81.76, -1.91 -93.74, -14.98 APE12-dist-na 10.5477 APE11-dist-na 11.1621 APE10-dist-na 13.9629 APE9-dist-out 8.9485 None None None XRAY 2.4 0.214 0.256 C 294.0 287.0 5 31 31 0 [[521, 779], [822, 1097]] 2.0 7apg Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7APGD P52333 815 1103 1124.0 RQT:61201 Type1 Inactive DFGin 6.0092 14.041 BLAminus -143.73, -171.03 51.78, 85.49 -96.62, 26.59 283.85, 72.76 -64.13, -26.23 in-in in 8.434 Saltbr-in 3.0873 HRD-in -83.66, -49.57 81.52, -47.38 in-in-out SNCiio in-out ActLoopNT-in 2.9154 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -120.66, 45.43 APE9-dihe-in -76.74, 156.2 APE8-dihe-in -73.01, 137.72 APE8-rot-na 354.08 APE67-dihe-in -79.85, -1.41 -95.44, -12.08 APE12-dist-na 10.8366 APE11-dist-na 10.5366 APE10-dist-na 13.2359 APE9-dist-out 8.9582 None None None XRAY 2.4 0.214 0.256 D 294.0 277.0 12 31 31 0 [[521, 779], [822, 1097]] 2.0 7apg Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5LWNA P52333 814 1103 1124.0 79R:1208,79S:1209 Type1,Type1 Inactive DFGin 6.1459 14.132 BLAminus -129.49, -162.36 48.02, 73.73 -88.01, 20.06 281.83, 72.86 -61.77, -25.11 in-in in 7.8172 Saltbr-in 2.7083 HRD-in -84.52, -44.16 75.64, -46.25 in-in-out SNCiio in-out ActLoopNT-in 2.8251 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -141.38, 98.08 APE9-dihe-in -113.86, 140.78 APE8-dihe-in -73.27, 87.08 APE8-rot-na 29.33 APE67-dihe-in -77.95, -2.97 -61.74, -27.63 APE12-dist-na 10.0824 APE11-dist-na 13.4052 APE10-dist-na 12.4459 APE9-dist-out 8.904 None None None XRAY 1.6 0.169 0.209 A 294.0 290.0 0 31 31 0 [[521, 779], [822, 1097]] 2.0 5lwn Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6HZVA P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.4293 14.257 BLAminus -133.87, 178.6 61.51, 90.4 -109.85, 28.17 289.99, 77.52 -67.6, -31.52 in-in in 8.3241 Saltbr-in 2.9312 HRD-in -62.66, -43.13 71.32, -8.68 in-in-none SNCiin in-none ActLoopNT-in 2.7324 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 119.68 APE8-rot-na 14.07 APE67-dihe-in -79.55, -1.3 -80.03, -13.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 A 285.0 266.0 18 31 26 5 [[521, 779], [822, 1097]] 2.0 6hzv Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6HZVB P52333 815 1099 1124.0 GYW:1101 Type1 None DFGin 6.1943 14.2143 BLAminus -135.38, 176.48 64.47, 86.88 -105.43, 20.89 286.69, 85.17 -66.35, -29.51 in-in in 8.1494 Saltbr-in 2.8265 HRD-in -61.18, -44.44 71.7, 4.93 in-in-none SNCiin in-none ActLoopNT-in 2.6907 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 129.11 APE8-rot-na 330.57 APE67-dihe-in -79.98, -2.63 -77.74, -18.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 B 285.0 269.0 16 31 25 6 [[521, 779], [822, 1097]] 2.0 6hzv Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6HZVC P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.477 14.2719 BLAminus -130.86, 179.06 58.44, 90.28 -109.09, 23.07 290.05, 84.12 -62.59, -33.96 in-in in 8.0905 Saltbr-in 2.8088 HRD-in -69.82, -48.24 78.15, -8.29 in-in-none SNCiin in-none ActLoopNT-in 2.6892 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -41.25 APE8-dihe-in -66.72, 131.5 APE8-rot-na 341.69 APE67-dihe-in -75.5, -7.29 -73.63, -18.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.346 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 C 285.0 265.0 19 31 26 5 [[521, 779], [822, 1097]] 2.0 6hzv Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6HZVD P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.418 14.1518 BLAminus -133.07, -178.12 58.66, 85.08 -104.02, 25.84 292.67, 81.24 -61.98, -32.78 in-in in 8.1402 Saltbr-in 2.7701 HRD-in -71.74, -43.92 75.22, -14.51 in-in-none SNCiin in-none ActLoopNT-in 2.7079 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -35.5 APE8-dihe-in -66.27, 131.93 APE8-rot-na 340.52 APE67-dihe-in -79.97, 1.1 -77.2, -17.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6337 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 D 285.0 259.0 25 31 26 5 [[521, 779], [822, 1097]] 2.0 6hzv Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5W86B P52333 816 1098 1124.0 9YV:4000 Type1 None DFGin 6.5719 14.1258 BLAminus -130.89, -177.7 55.33, 86.59 -98.74, 23.53 285.65, 80.73 -58.36, -36.34 in-in in 8.1755 Saltbr-in 2.7815 HRD-in -61.09, -43.56 75.39, -22.05 in-in-none SNCiin in-none ActLoopNT-in 2.8266 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-in -98.06, 144.28 APE8-rot-na 28.22 APE67-dihe-in -84.46, -5.87 -122.29, -17.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7561 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 B 287.0 269.0 14 31 26 5 [[521, 779], [822, 1097]] 2.0 5w86 Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5W86C P52333 814 1099 1124.0 9YV:4000 Type1 None DFGin 6.5069 14.1113 BLAminus -131.5, -178.51 55.57, 86.1 -97.59, 23.31 285.7, 80.13 -57.67, -36.43 in-in in 8.1655 Saltbr-in 2.9403 HRD-in -62.63, -48.44 77.31, -20.33 in-in-none SNCiin in-none ActLoopNT-in 2.8223 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -67.29 APE8-rot-na 15.79 APE67-dihe-in -70.13, -18.29 -58.03, -20.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 C 287.0 275.0 11 31 25 6 [[521, 779], [822, 1097]] 2.0 5w86 Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6AAKD P52333 814 1098 1124.0 9T6:1201 Type1 None DFGin 6.3309 14.1383 BLAminus -145.03, 168.99 56.55, 97.11 -103.75, 32.24 293.47, 81.71 -62.01, -33.71 in-in in 8.0179 Saltbr-in 2.8556 HRD-in -76.49, -42.81 76.74, -36.27 in-in-none SNCiin in-none ActLoopNT-in 2.7662 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 72.65 APE8-dihe-in -50.29, 134.06 APE8-rot-na 332.19 APE67-dihe-in -63.85, -16.03 -70.13, -20.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3842 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.67 0.269 0.326 D 287.0 268.0 17 31 26 5 [[521, 779], [822, 1097]] 2.0 6aak Homo sapiens TYR_JAK3-2_HUMAN TYR 1.9e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 3ZC6B P52333 813 1100 1124.0 VFC:2103 Type1 None DFGin 6.2181 14.0462 BLAminus -128.88, -176.96 59.69, 81.97 -99.61, 22.0 289.18, 82.46 -63.53, -20.72 in-in in 8.2087 Saltbr-in 2.7991 HRD-in -71.31, -49.71 79.31, 3.34 in-in-none SNCiin in-none ActLoopNT-in 2.7475 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 25.15 APE9-dihe-in -99.95, 171.81 APE8-dihe-in -50.02, 112.29 APE8-rot-na 325.04 APE67-dihe-in -73.29, -4.3 -58.87, -25.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.4818 APE9-dist-in 6.8402 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 B 288.0 278.0 10 31 27 4 [[521, 779], [822, 1097]] 2.0 3zc6 Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 3ZC6D P52333 814 1100 1124.0 VFC:2103 Type1 None DFGin 6.3147 14.132 BLAminus -134.59, -176.68 59.2, 81.95 -97.58, 24.75 285.45, 76.49 -66.73, -25.04 in-in in 8.057 Saltbr-in 2.7416 HRD-in -74.86, -52.02 77.99, -12.75 in-in-none SNCiin in-none ActLoopNT-in 2.7303 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 79.2 APE8-rot-na 32.25 APE67-dihe-in -80.63, -5.09 -78.85, -21.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 D 288.0 269.0 18 31 26 5 [[521, 779], [822, 1097]] 2.0 3zc6 Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 3ZEPB P52333 814 1100 1124.0 1NX:2101 Type1 None DFGin 6.3528 14.2219 BLAminus -142.2, 177.46 62.39, 84.45 -101.38, 32.38 292.96, 77.07 -73.1, -37.75 in-in in 8.2407 Saltbr-in 2.735 HRD-in -71.3, -45.86 73.98, -5.89 in-in-none SNCiin in-none ActLoopNT-in 2.7688 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 174.81 APE8-dihe-in -59.17, 141.04 APE8-rot-na 332.8 APE67-dihe-in -80.76, -5.98 -67.68, -15.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.4769 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 B 288.0 270.0 17 31 27 4 [[521, 779], [822, 1097]] 2.0 3zep Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 3ZEPC P52333 814 1100 1124.0 1NX:2101 Type1 None DFGin 6.2667 14.2845 BLAminus -143.3, 179.56 63.59, 86.35 -106.32, 31.56 290.45, 75.82 -68.82, -32.0 in-in in 8.1744 Saltbr-in 2.7545 HRD-in -76.43, -48.0 76.34, -21.16 in-in-none SNCiin in-none ActLoopNT-in 2.7144 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 45.01 APE9-dihe-in -93.38, 161.79 APE8-dihe-in -56.5, 116.98 APE8-rot-na 326.42 APE67-dihe-in -74.98, -4.7 -72.25, -13.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.7287 APE9-dist-in 6.8497 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 C 288.0 278.0 9 31 29 2 [[521, 779], [822, 1097]] 2.0 3zep Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 3ZEPD P52333 814 1099 1124.0 1NX:2100 Type1 None DFGin 6.5755 14.572 BLAminus -134.12, 176.57 59.25, 80.73 -100.38, 28.57 291.24, 76.13 -63.83, -42.01 in-in in 8.3615 Saltbr-in 2.6719 HRD-in -72.39, -47.07 79.2, -13.88 in-in-none SNCiin in-none ActLoopNT-in 2.7779 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 161.47 APE8-dihe-in -52.69, 138.76 APE8-rot-na 329.47 APE67-dihe-in -77.9, -7.22 -77.25, -13.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.5559 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 D 288.0 274.0 12 31 28 3 [[521, 779], [822, 1097]] 2.0 3zep Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 7UYVD P52333 814 1100 1124.0 OV5:1201 Type1 None DFGin 6.4207 14.2582 BLAminus -133.29, -179.06 58.4, 83.86 -99.71, 22.65 285.23, 81.71 -62.49, -28.09 in-in in 8.2976 Saltbr-in 2.6722 HRD-in -64.99, -48.29 76.96, -0.25 in-in-none SNCiin in-none ActLoopNT-in 2.7457 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 163.98 APE8-dihe-in -58.27, 129.89 APE8-rot-na 335.93 APE67-dihe-in -80.69, -3.3 -71.81, -12.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4681 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 D 291.0 272.0 15 31 26 5 [[521, 779], [822, 1097]] 2.0 7uyv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 5VO6A P52333 815 1099 1124.0 9J4:4000 Type1 None DFGin 6.5587 13.7482 BLAminus -128.78, -173.97 61.05, 89.09 -107.4, 19.66 285.17, 86.8 -68.24, -28.8 in-in in 7.5123 Saltbr-in 2.9107 HRD-in -75.3, -50.06 76.72, -16.95 in-in-none SNCiin in-none ActLoopNT-in 2.9825 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 135.66 APE8-rot-na 332.57 APE67-dihe-in -81.44, -5.82 -70.82, -9.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C1040S,C1048S None None XRAY 2.65 0.215 0.284 A 293.0 271.0 14 31 25 6 [[521, 779], [822, 1097]] 2.0 5vo6 Homo sapiens TYR_JAK3-2_HUMAN TYR 2.1e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6NY4A P52333 815 1099 1124.0 Z3A:4000 Type1 None DFGin 6.4319 13.7522 BLAminus -130.0, -166.41 50.15, 85.44 -100.28, 21.12 284.91, 84.56 -64.41, -23.36 in-in in 7.6903 Saltbr-in 2.7769 HRD-in -74.4, -47.07 70.71, -6.14 in-in-none SNCiin in-none ActLoopNT-in 2.8428 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -0.08 APE9-dihe-in -95.23, 160.07 APE8-dihe-in -49.81, 129.43 APE8-rot-na 333.86 APE67-dihe-in -73.45, 2.08 -64.08, -16.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.7064 APE9-dist-in 7.0951 C811S,C1040S,C1048S None None XRAY 2.33 0.216 0.241 A 293.0 277.0 8 31 27 4 [[521, 779], [822, 1097]] 2.0 6ny4 Homo sapiens TYR_JAK3-2_HUMAN TYR 2.1e-81 279.0 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4V0GB P52333 816 1098 1124.0 G9B:2099 Type1 None DFGin 6.202 14.6329 BLAminus -137.8, -174.69 52.03, 76.68 -96.09, 37.57 296.46, 78.81 -70.34, -40.16 in-in in 8.7004 Saltbr-in 2.629 HRD-in -75.76, -37.0 67.95, -17.09 in-in-none SNCiin in-none ActLoopNT-in 2.8243 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -54.69 APE8-rot-na 331.57 APE67-dihe-in -77.98, -0.68 -62.56, -42.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 3.0 0.254 0.295 B 283.0 274.0 9 31 26 5 [[521, 779], [822, 1097]] 2.0 4v0g Homo sapiens TYR_JAK3-2_HUMAN TYR 2.3e-81 278.9 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4V0GA P52333 817 1098 1124.0 G9B:2099 Type1 None DFGin 6.198 14.7166 BLAminus -144.75, -176.45 39.25, 85.88 -90.52, 22.25 286.27, 74.42 -61.38, -18.98 in-in in 8.3521 Saltbr-in 2.7066 HRD-in -65.46, -44.14 69.1, 4.41 in-in-none SNCiin in-none ActLoopNT-in 2.8503 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -33.75 APE8-rot-na 330.77 APE67-dihe-in -73.45, -1.83 -68.02, -39.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 3.0 0.254 0.295 A 283.0 269.0 13 31 27 4 [[521, 779], [822, 1097]] 2.0 4v0g Homo sapiens TYR_JAK3-2_HUMAN TYR 2.3e-81 278.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4Z16A P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.693 14.5354 BLAminus -125.11, -170.67 46.31, 83.09 -100.98, 26.25 290.17, 83.28 -67.99, -29.42 in-in in 8.3468 Saltbr-in 2.8339 HRD-in -67.29, -45.59 73.41, -19.17 in-in-none SNCiin in-none ActLoopNT-in 2.8291 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 77.57 APE8-rot-na 328.09 APE67-dihe-in -74.64, -13.67 -80.93, -12.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 A 316.0 273.0 17 31 26 5 [[521, 779], [822, 1097]] 2.0 4z16 Homo sapiens TYR_JAK3-2_HUMAN TYR 7.5e-81 277.2 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4Z16C P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.724 14.5409 BLAminus -124.89, -171.04 46.95, 83.36 -101.0, 25.74 290.21, 83.17 -68.15, -28.94 in-in in 8.3723 Saltbr-in 2.8403 HRD-in -67.03, -45.78 73.53, -19.66 in-in-none SNCiin in-none ActLoopNT-in 2.7882 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 38.92 APE8-rot-na 335.43 APE67-dihe-in -76.63, -13.6 -68.45, -18.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 C 316.0 273.0 17 31 26 5 [[521, 779], [822, 1097]] 2.0 4z16 Homo sapiens TYR_JAK3-2_HUMAN TYR 7.5e-81 277.2 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4Z16D P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.6883 14.5667 BLAminus -124.04, -170.5 45.94, 82.68 -99.35, 24.89 290.17, 82.54 -66.47, -27.42 in-in in 8.3931 Saltbr-in 2.8748 HRD-in -67.23, -45.45 73.09, -20.62 in-in-none SNCiin in-none ActLoopNT-in 2.7942 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 52.48 APE8-rot-na 345.61 APE67-dihe-in -77.91, -13.97 -72.79, -6.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 D 316.0 273.0 17 31 26 5 [[521, 779], [822, 1097]] 2.0 4z16 Homo sapiens TYR_JAK3-2_HUMAN TYR 7.5e-81 277.2 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 4QPSA P52333 814 1100 1124.0 37Q:1201 Type1 None DFGin 6.8957 14.0909 BLAminus -130.94, -174.49 64.52, 86.82 -104.86, 15.71 281.27, 81.21 -57.28, -32.23 in-in in 8.5879 Saltbr-in 2.8637 HRD-in -78.56, -46.33 74.55, -53.21 in-in-none SNCiin in-none ActLoopNT-in 2.801 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 149.07 APE8-rot-na 18.94 APE67-dihe-in -69.31, -9.6 -100.11, -5.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D949A,C1040S,C1048S None None XRAY 1.8 0.21 0.251 A 293.0 270.0 17 31 25 6 [[521, 779], [822, 1097]] 2.0 4qps Homo sapiens TYR_JAK3-2_HUMAN TYR 3.9e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6GLAA P52333 813 1103 1124.0 F4B:1201 Type1 None DFGin 6.1255 14.0661 BLAminus -126.69, -163.69 45.61, 84.37 -97.16, 18.74 276.14, 73.33 -60.39, -30.05 in-in in 7.8334 Saltbr-in 2.6744 HRD-in -80.36, -50.35 74.06, -4.7 in-in-none SNCiin in-none ActLoopNT-in 2.7495 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 115.39 APE9-dihe-in -100.65, 143.31 APE8-dihe-in -75.22, 92.35 APE8-rot-na 30.49 APE67-dihe-in -81.25, -0.82 -60.88, -31.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.6793 APE9-dist-in 7.0014 None None None XRAY 1.92 0.228 0.273 A 294.0 288.0 3 31 28 3 [[521, 779], [822, 1097]] 2.0 6gla Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6GLAB P52333 813 1103 1124.0 F4B:1201 Type1 None DFGin 6.1346 14.0372 BLAminus -126.98, -166.17 47.87, 84.06 -100.26, 19.16 275.64, 73.52 -60.46, -30.51 in-in in 7.8307 Saltbr-in 2.6702 HRD-in -83.39, -49.56 74.28, -3.93 in-in-none SNCiin in-none ActLoopNT-in 2.7748 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 114.52 APE9-dihe-in -101.31, 145.02 APE8-dihe-in -77.95, 91.55 APE8-rot-na 29.11 APE67-dihe-in -79.72, -1.04 -62.76, -29.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.7449 APE9-dist-in 6.9663 None None None XRAY 1.92 0.228 0.273 B 294.0 286.0 5 31 28 3 [[521, 779], [822, 1097]] 2.0 6gla Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6GLBA P52333 813 1103 1124.0 F48:1201 Type1 None DFGin 6.0868 14.0047 BLAminus -127.29, -165.11 42.2, 80.94 -98.99, 18.18 281.6, 72.22 -46.91, -40.63 in-in in 7.5761 Saltbr-in 2.7125 HRD-in -78.7, -52.76 77.75, 9.6 in-in-none SNCiin in-none ActLoopNT-in 2.7344 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 129.22 APE9-dihe-in -106.96, 151.72 APE8-dihe-in -79.63, 91.52 APE8-rot-na 32.17 APE67-dihe-in -74.91, -5.23 -62.01, -34.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.734 APE9-dist-in 6.7274 None None None XRAY 2.0 0.236 0.29 A 294.0 288.0 3 31 28 3 [[521, 779], [822, 1097]] 2.0 6glb Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 6GLBB P52333 813 1103 1124.0 F48:1201 Type1 None DFGin 6.117 14.0249 BLAminus -125.81, -165.95 42.86, 80.87 -97.87, 18.6 282.22, 74.99 -51.1, -37.8 in-in in 7.5451 Saltbr-in 2.7085 HRD-in -76.97, -51.62 77.21, 8.56 in-in-none SNCiin in-none ActLoopNT-in 2.7568 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 130.97 APE9-dihe-in -105.16, 150.45 APE8-dihe-in -79.13, 89.35 APE8-rot-na 33.14 APE67-dihe-in -76.14, -3.82 -57.76, -35.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.6293 APE9-dist-in 6.7039 None None None XRAY 2.0 0.236 0.29 B 294.0 288.0 3 31 28 3 [[521, 779], [822, 1097]] 2.0 6glb Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 9R5ZA P52333 822 1101 1124.0 A1JJU:60301 Type1 None DFGin 6.1324 14.0012 BLAminus -127.52, -161.85 48.17, 81.61 -92.0, 24.85 277.91, 73.75 -73.44, -23.7 in-in in 7.6679 Saltbr-in 2.7676 HRD-in -79.16, -47.46 79.61, -35.13 in-in-none SNCiin in-none ActLoopNT-in 2.8804 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.63 APE8-rot-na 20.77 APE67-dihe-in -76.47, -3.83 -62.4, -34.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.239 0.289 A 294.0 258.0 22 31 26 5 [[521, 779], [822, 1097]] 2.0 9r5z Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
JAK3-2 JAK3_HUMAN 9R5ZB P52333 816 1101 1124.0 A1JJU:60301 Type1 None DFGin 6.2264 14.1304 BLAminus -127.35, -164.41 49.32, 77.12 -91.09, 23.07 281.2, 72.28 -62.52, -23.26 in-in in 7.8816 Saltbr-in 2.8186 HRD-in -86.18, -46.89 79.27, -42.6 in-in-none SNCiin in-none ActLoopNT-in 2.8747 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 79.25 APE8-rot-na 31.77 APE67-dihe-in -82.31, -0.99 -65.94, -24.16 APE12-dist-na 11.0451 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.239 0.289 B 294.0 275.0 11 31 28 3 [[521, 779], [822, 1097]] 2.0 9r5z Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3

TYR_JAK3-2 (Tyrosine-protein kinase JAK3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name