TYR_JAK2-1 (Tyrosine-protein kinase JAK2)

Total number of chains: 61
Active chains: 0
Family: TYR
Uniprot: JAK2_HUMAN
Kinase Domain Residues: 545 - 807
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 61 100.0% 8BA3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
5I4NA 1.54 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 809 0 None E596A,V617F,W659A,W777A,F794H Tyrosine-protein kinase JAK2
4FVRA 2.0 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None V617F,W777A,F794H Tyrosine-protein kinase JAK2
4FVQA 1.75 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8C08A 2.2 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8C08B 2.2 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8BA4B 2.1 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
4FVPA 2.01 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8C09A 1.9 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 538 - 809 0 None I559F,W659A,W777A,F794H Tyrosine-protein kinase JAK2
6G3CA 1.6 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao EKT Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6G3CB 1.6 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao EKT Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6D2IA 3.192 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6D2IB 3.192 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8B8NA 2.0 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8B8UA 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8B8UB 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 538 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8BA2A 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q9X Type1 536 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8BA4A 2.1 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao Q8U Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
7F7WA 1.83 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 36H Type1 536 - 810 0 None None Tyrosine-protein kinase JAK2
7F7WB 1.83 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 36H Type1 536 - 810 0 None None Tyrosine-protein kinase JAK2
8B99A 1.6 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2
8B9EA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2
8BABA 1.55 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q8N Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2
8BAKA 1.65 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao AD5 Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2
8C0AA 1.7 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 809 0 None W659A,R683S,W777A,F794H Tyrosine-protein kinase JAK2
8C0AB 1.7 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 808 0 None W659A,R683S,W777A,F794H Tyrosine-protein kinase JAK2
5WIJA 2.04 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5WIKB 2.6 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 584 Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5WILA 2.2 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao YDJ Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5WIMA 2.55 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5WINA 2.38 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5USZA 2.103 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5UT0A 2.102 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5UT1A 1.95 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 7DZ Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5UT2A 1.75 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 3YT Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5UT3A 1.501 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao IK1 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5UT4A 2.0 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao DQX Type1 537 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5UT5A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 2HB Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
5UT6A 1.645 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 8MY Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6BRWA 2.031 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 5BS Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6BS0A 1.541 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao E4V Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6BSSA 2.1 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 4SP Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6M9HA 1.79 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao J9D Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6OAVA 1.939 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao M3A Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6OBBA 1.904 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M3Y Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6OBFA 1.71 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M4G Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6OBLA 2.061 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M4P Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6OCCA 2.03 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M57 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
6XJKA 2.024 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao V4D Type1 539 - 807 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
7JYOA 2.161 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VPS Type1 539 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
7JYQA 1.859 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao VPJ Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
7SZWA 1.906 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao DVY Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
7T0PA 2.04 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E3W Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
7T0PB 2.04 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E3W Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
7T1TA 2.08 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E8I Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8B9HA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8BA3A 1.4 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q8U Type1 536 - 812 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8EX0A 1.85 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8EX1A 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AD5 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
8EX2A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao Q2Q Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
9ND5A 2.4 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao A1BXA Type1 536 - 809 0 None None Tyrosine-protein kinase JAK2
9ND3A 1.62 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao A1BW6 Type1 536 - 808 0 None None Tyrosine-protein kinase JAK2

TYR_JAK2-1 (Tyrosine-protein kinase JAK2)

Total number of chains: 61
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 61 100.0% 8BA3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
JAK2_HUMAN 5I4NA 1.54 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 809 0 None E596A,V617F,W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4FVRA 2.0 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None V617F,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4FVQA 1.75 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8C08A 2.2 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 537 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8C08B 2.2 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao ATP ATPlike 536 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BA4B 2.1 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 4FVPA 2.01 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8C09A 1.9 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao No_ligand No_ligand 538 - 809 0 None I559F,W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6G3CA 1.6 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao EKT Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6G3CB 1.6 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao EKT Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6D2IA 3.192 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6D2IB 3.192 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8B8NA 2.0 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8B8UA 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8B8UB 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 538 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BA2A 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q9X Type1 536 - 810 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BA4A 2.1 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao Q8U Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7F7WA 1.83 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 36H Type1 536 - 810 0 None None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7F7WB 1.83 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 36H Type1 536 - 810 0 None None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8B99A 1.6 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8B9EA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BABA 1.55 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q8N Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BAKA 1.65 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao AD5 Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8C0AA 1.7 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 809 0 None W659A,R683S,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8C0AB 1.7 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao T7I Type1 536 - 808 0 None W659A,R683S,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5WIJA 2.04 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5WIKB 2.6 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 584 Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5WILA 2.2 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao YDJ Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5WIMA 2.55 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5WINA 2.38 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5USZA 2.103 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao SKE Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5UT0A 2.102 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 35R Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5UT1A 1.95 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 7DZ Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5UT2A 1.75 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 3YT Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5UT3A 1.501 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao IK1 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5UT4A 2.0 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao DQX Type1 537 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5UT5A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 2HB Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 5UT6A 1.645 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 8MY Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6BRWA 2.031 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 5BS Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6BS0A 1.541 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao E4V Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6BSSA 2.1 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao 4SP Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6M9HA 1.79 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao J9D Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6OAVA 1.939 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao M3A Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6OBBA 1.904 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M3Y Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6OBFA 1.71 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M4G Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6OBLA 2.061 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M4P Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6OCCA 2.03 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao M57 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 6XJKA 2.024 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao V4D Type1 539 - 807 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7JYOA 2.161 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao VPS Type1 539 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7JYQA 1.859 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao VPJ Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7SZWA 1.906 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao DVY Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7T0PA 2.04 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E3W Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7T0PB 2.04 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E3W Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 7T1TA 2.08 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao E8I Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8B9HA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8BA3A 1.4 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q8U Type1 536 - 812 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8EX0A 1.85 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AQG Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8EX1A 1.5 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AD5 Type1 537 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 8EX2A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao Q2Q Type1 536 - 808 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 9ND5A 2.4 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao A1BXA Type1 536 - 809 0 None None Tyrosine-protein kinase JAK2 Homo sapiens
JAK2_HUMAN 9ND3A 1.62 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao A1BW6 Type1 536 - 808 0 None None Tyrosine-protein kinase JAK2 Homo sapiens

TYR_JAK2-1 (Tyrosine-protein kinase JAK2)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism