TYR_JAK2-1 (Tyrosine-protein kinase JAK2)

Total number of chains: 61
Active chains: 0
Uniprot: JAK2_HUMAN
Kinase Domain Residues: 545 - 807
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 61 100.0% 8BA3A

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
JAK2-1 5I4NA O60674 537 809 1132.0 ATP:61000 ATPlike Pseudo DFGin 5.6682 13.3858 None -68.19, 172.29 -64.41, 158.19 -73.31, -26.63 342.84, 34.8 77.82, -169.16 out-na out 11.405 Saltbr-na 999.0 HRD-in -78.6, -60.98 86.96, 3.87 na-out-out SNCaoo out-out ActLoopNT-out 8.6814 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.12, -41.49 APE9-dihe-out -58.18, -29.35 APE8-dihe-out -88.11, 6.74 APE8-rot-na 290.83 APE67-dihe-out -103.83, 26.01 -65.06, 135.53 APE12-dist-na 10.0371 APE11-dist-na 11.7 APE10-dist-na 16.2781 APE9-dist-out 12.3723 E596A,V617F,W659A,W777A,F794H None None XRAY 1.54 0.174 0.193 A 290.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5i4n TYR_JAK2-1_HUMAN TYR 7.1e-64 221.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 4FVRA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 5.7656 13.3758 None -77.86, -178.54 -72.61, 163.95 -75.06, -27.39 334.11, 39.64 77.27, -166.65 out-na out 11.7821 Saltbr-na 999.0 HRD-in -74.66, -57.27 90.8, -3.55 na-out-out SNCaoo out-out ActLoopNT-out 8.5367 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.48, -33.68 APE9-dihe-out -63.8, -34.8 APE8-dihe-out -85.1, 11.44 APE8-rot-na 293.02 APE67-dihe-out -101.64, 24.24 -66.8, 135.55 APE12-dist-na 9.675 APE11-dist-na 11.4734 APE10-dist-na 16.0369 APE9-dist-out 12.0279 V617F,W777A,F794H None None XRAY 2.0 0.183 0.229 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvr TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 4FVQA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 6.4109 13.5312 None -82.38, -178.3 -71.29, 157.18 -64.23, -31.16 342.38, 32.32 77.45, -167.94 out-na out 10.3574 Saltbr-na 999.0 HRD-in -81.79, -59.57 93.66, -10.87 na-out-out SNCaoo out-out ActLoopNT-out 9.0941 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.14, -35.28 APE9-dihe-out -67.39, -22.98 APE8-dihe-out -92.26, 6.93 APE8-rot-na 290.03 APE67-dihe-out -106.47, 27.81 -64.4, 133.6 APE12-dist-na 9.9123 APE11-dist-na 11.4873 APE10-dist-na 16.0746 APE9-dist-out 12.3782 W659A,W777A,F794H None None XRAY 1.75 0.176 0.199 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvq TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8C08A O60674 537 810 1132.0 ATP:901 ATPlike Pseudo DFGin 6.5983 13.736 None -72.21, 176.69 -66.6, 164.57 -72.8, -15.2 349.18, 27.02 73.34, -163.25 in-na in 9.3998 Saltbr-na 999.0 HRD-in -80.72, -74.63 111.24, -16.83 na-out-out SNCaoo out-out ActLoopNT-out 9.4736 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.86, -37.52 APE9-dihe-out -72.05, -28.92 APE8-dihe-out -74.69, -10.21 APE8-rot-na 283.12 APE67-dihe-out -93.42, 18.23 -54.81, 139.34 APE12-dist-na 9.9203 APE11-dist-na 11.8594 APE10-dist-na 16.3524 APE9-dist-out 12.5304 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 A 289.0 270.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8C08B O60674 536 810 1132.0 ATP:901 ATPlike Pseudo DFGin 5.6459 13.5394 None -63.04, -178.12 -72.48, 164.14 -59.19, -39.37 337.51, 34.58 89.58, -173.09 out-na out 12.1784 Saltbr-na 999.0 HRD-in -76.08, -63.96 89.49, 0.26 na-out-out SNCaoo out-out ActLoopNT-out 8.7296 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.09, -36.29 APE9-dihe-out -67.21, -14.45 APE8-dihe-out -97.09, 0.9 APE8-rot-na 279.42 APE67-dihe-out -95.31, 21.21 -63.75, 135.54 APE12-dist-na 10.8478 APE11-dist-na 11.8372 APE10-dist-na 16.5999 APE9-dist-out 12.658 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 B 289.0 269.0 6 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8BA4B O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.0162 13.6285 None -84.33, -175.92 -78.92, 160.47 -67.97, -29.51 344.52, 29.43 84.02, -159.01 out-na out 10.5477 Saltbr-na 999.0 HRD-in -80.56, -60.88 93.85, -0.35 na-out-out SNCaoo out-out ActLoopNT-out 9.2529 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.77, -41.18 APE9-dihe-out -60.58, -30.76 APE8-dihe-out -85.29, 2.29 APE8-rot-na 288.75 APE67-dihe-out -100.46, 22.84 -59.03, 138.57 APE12-dist-na 9.6698 APE11-dist-na 11.3976 APE10-dist-na 15.9347 APE9-dist-out 12.6673 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 B 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba4 TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 4FVPA O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.8931 13.0904 None -91.01, 179.45 -75.79, 153.56 -78.3, -11.29 26.93, 143.21 73.75, -158.65 out-na out 13.1657 Saltbr-na 999.0 HRD-in -83.21, -62.84 93.75, -4.6 na-out-out SNCaoo out-out ActLoopNT-out 9.629 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.0, -41.33 APE9-dihe-out -58.79, -30.31 APE8-dihe-out -86.85, 3.46 APE8-rot-na 297.22 APE67-dihe-out -102.61, 25.98 -63.62, 134.65 APE12-dist-na 9.8827 APE11-dist-na 11.6748 APE10-dist-na 16.1441 APE9-dist-out 12.5432 W659A,W777A,F794H None None XRAY 2.01 0.181 0.212 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvp TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8C09A O60674 538 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.0525 13.2527 None -86.22, -176.26 -73.29, 161.33 -72.41, -30.09 344.35, 29.81 80.16, -162.74 out-na out 11.184 Saltbr-na 999.0 HRD-in -80.44, -66.09 97.2, -4.64 na-out-out SNCaoo out-out ActLoopNT-out 9.0791 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.51, -34.73 APE9-dihe-out -64.77, -31.42 APE8-dihe-out -84.71, 1.64 APE8-rot-na 292.35 APE67-dihe-out -99.58, 28.31 -60.08, 137.86 APE12-dist-na 9.8638 APE11-dist-na 11.5573 APE10-dist-na 16.1216 APE9-dist-out 12.4835 I559F,W659A,W777A,F794H None None XRAY 1.9 0.223 0.257 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c09 TYR_JAK2-1_HUMAN TYR 1.3e-63 220.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6G3CA O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.9293 13.2972 None -92.88, -174.23 -74.55, 160.0 -77.81, -9.76 27.51, 143.79 70.13, -167.0 in-na in 9.4623 Saltbr-na 999.0 HRD-in -89.47, -61.45 91.27, -4.79 na-out-out SNCaoo out-out ActLoopNT-out 9.753 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.76, -39.79 APE9-dihe-out -61.91, -29.13 APE8-dihe-out -80.12, 0.2 APE8-rot-na 289.19 APE67-dihe-out -101.75, 22.48 -69.62, 136.72 APE12-dist-na 9.7666 APE11-dist-na 11.5665 APE10-dist-na 16.1545 APE9-dist-out 12.7021 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 A 272.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6g3c TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6G3CB O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.9902 13.415 None -91.77, -175.11 -73.45, 159.45 -76.52, -11.86 28.49, 143.52 73.41, -164.04 in-na in 9.643 Saltbr-na 999.0 HRD-in -89.94, -61.82 90.1, -3.95 na-out-out SNCaoo out-out ActLoopNT-out 9.6929 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.88, -39.41 APE9-dihe-out -62.88, -28.18 APE8-dihe-out -81.21, 1.24 APE8-rot-na 288.18 APE67-dihe-out -102.69, 23.29 -70.43, 136.03 APE12-dist-na 9.7694 APE11-dist-na 11.5802 APE10-dist-na 16.1381 APE9-dist-out 12.6902 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 B 272.0 268.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6g3c TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6D2IA O60674 536 808 1132.0 35R:901 Type1 Pseudo DFGin 6.5522 13.6514 None -85.6, -168.64 -71.02, 159.25 -67.8, -19.61 341.93, 32.5 72.61, -145.53 in-na in 9.6393 Saltbr-na 999.0 HRD-in -88.15, -70.56 100.36, -8.76 na-out-out SNCaoo out-out ActLoopNT-out 9.7002 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.19, -30.63 APE9-dihe-out -73.76, -13.56 APE8-dihe-out -89.52, 2.58 APE8-rot-na 300.29 APE67-dihe-out -99.98, 28.53 -66.76, 135.82 APE12-dist-na 10.5196 APE11-dist-na 11.5137 APE10-dist-na 16.3152 APE9-dist-out 13.0189 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 A 273.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6D2IB O60674 537 808 1132.0 35R:901 Type1 Pseudo DFGin 6.7449 13.508 None -83.97, -172.62 -69.78, 158.02 -65.46, -20.62 341.26, 32.34 71.79, -145.54 in-na in 9.4363 Saltbr-na 999.0 HRD-in -84.58, -69.97 97.0, -6.55 na-out-out SNCaoo out-out ActLoopNT-out 9.4489 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.97, -30.79 APE9-dihe-out -72.59, -17.09 APE8-dihe-out -89.77, 2.61 APE8-rot-na 301.92 APE67-dihe-out -99.31, 27.86 -67.19, 135.78 APE12-dist-na 10.5863 APE11-dist-na 11.8904 APE10-dist-na 16.6501 APE9-dist-out 12.8955 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 B 273.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8B8NA O60674 536 809 1132.0 AQG:904 Type1 Pseudo DFGin 6.9922 13.5588 None -86.6, 176.83 -72.07, 163.0 -83.55, -11.71 8.83, 7.64 73.11, -166.45 out-na out 10.2232 Saltbr-na 999.0 HRD-in -77.47, -60.54 92.78, -1.1 na-out-out SNCaoo out-out ActLoopNT-out 9.2549 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.27, -38.06 APE9-dihe-out -61.66, -30.26 APE8-dihe-out -80.2, 3.05 APE8-rot-na 289.81 APE67-dihe-out -99.17, 33.25 -63.6, 138.44 APE12-dist-na 9.5537 APE11-dist-na 11.4484 APE10-dist-na 15.9705 APE9-dist-out 12.4531 W659A,W777A,F794H None None XRAY 2.0 0.211 0.255 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8n TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8B8UA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.821 13.2982 None -86.5, 168.2 -72.83, 159.81 -77.39, -5.69 29.32, 142.66 68.85, -165.5 in-na in 9.6368 Saltbr-na 999.0 HRD-in -85.53, -63.36 91.05, -0.77 na-out-out SNCaoo out-out ActLoopNT-out 9.5857 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -40.18 APE9-dihe-out -60.78, -27.05 APE8-dihe-out -85.5, 2.2 APE8-rot-na 288.85 APE67-dihe-out -105.88, 26.49 -64.53, 136.9 APE12-dist-na 9.8393 APE11-dist-na 11.5435 APE10-dist-na 16.1353 APE9-dist-out 12.651 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8u TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8B8UB O60674 538 809 1132.0 T7I:903 Type1 Pseudo DFGin 7.6842 13.3671 None -85.95, 172.23 -73.23, 159.57 -79.19, -7.74 28.18, 144.77 71.86, -165.96 in-na in 9.8706 Saltbr-na 999.0 HRD-in -85.44, -62.47 91.56, -1.37 na-out-out SNCaoo out-out ActLoopNT-out 9.4049 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.42, -39.8 APE9-dihe-out -61.59, -26.48 APE8-dihe-out -85.69, -0.76 APE8-rot-na 289.8 APE67-dihe-out -104.95, 23.87 -61.36, 134.02 APE12-dist-na 9.8928 APE11-dist-na 11.4874 APE10-dist-na 16.1064 APE9-dist-out 12.5476 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 B 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8u TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8BA2A O60674 536 810 1132.0 Q9X:907 Type1 Pseudo DFGin 5.7073 13.2724 None -74.82, 174.75 -67.11, 161.11 -77.71, -21.19 340.67, 34.41 73.6, -166.64 out-na out 11.6572 Saltbr-na 999.0 HRD-in -83.09, -59.59 87.04, -0.99 na-out-out SNCaoo out-out ActLoopNT-out 8.9491 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.59, -40.16 APE9-dihe-out -57.17, -31.99 APE8-dihe-out -85.57, 4.75 APE8-rot-na 288.77 APE67-dihe-out -102.79, 29.41 -64.21, 136.1 APE12-dist-na 9.7351 APE11-dist-na 11.4317 APE10-dist-na 16.0182 APE9-dist-out 12.2832 W659A,W777A,F794H None None XRAY 1.5 0.178 0.204 A 289.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba2 TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8BA4A O60674 536 809 1132.0 Q8U:901 Type1 Pseudo DFGin 7.9438 13.4117 None -71.69, 172.79 -67.86, 161.07 -79.48, -19.97 29.54, 146.52 81.3, -166.68 in-na in 9.7879 Saltbr-na 999.0 HRD-in -74.34, -63.4 91.62, 2.89 na-out-out SNCaoo out-out ActLoopNT-out 8.5896 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.98, -39.28 APE9-dihe-out -56.91, -30.54 APE8-dihe-out -86.08, -1.03 APE8-rot-na 290.49 APE67-dihe-out -99.32, 21.83 -60.56, 137.6 APE12-dist-na 9.9255 APE11-dist-na 11.6473 APE10-dist-na 16.1443 APE9-dist-out 12.3271 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba4 TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 7F7WA O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.915 13.7962 None -91.54, 171.73 -67.57, 155.24 -69.34, -22.33 351.29, 21.05 78.83, -168.1 out-na out 10.1693 Saltbr-na 999.0 HRD-in -84.02, -62.23 90.48, 0.05 na-out-out SNCaoo out-out ActLoopNT-out 9.7232 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.04, -35.76 APE9-dihe-out -66.77, -25.16 APE8-dihe-out -85.21, 3.67 APE8-rot-na 284.34 APE67-dihe-out -100.56, 25.85 -66.38, 135.35 APE12-dist-na 9.6893 APE11-dist-na 11.4731 APE10-dist-na 16.0322 APE9-dist-out 12.6531 None None None XRAY 1.83 0.208 0.238 A 275.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7f7w TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 7F7WB O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.9033 13.6869 None -84.95, 175.07 -74.42, 156.63 -70.62, -23.21 351.87, 21.25 77.0, -167.15 out-na out 10.2517 Saltbr-na 999.0 HRD-in -79.03, -66.0 95.6, -1.12 na-out-out SNCaoo out-out ActLoopNT-out 9.4951 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.33, -37.68 APE9-dihe-out -69.53, -21.97 APE8-dihe-out -87.12, 4.19 APE8-rot-na 285.11 APE67-dihe-out -99.09, 24.95 -67.63, 136.04 APE12-dist-na 9.7044 APE11-dist-na 11.4907 APE10-dist-na 16.0173 APE9-dist-out 12.671 None None None XRAY 1.83 0.208 0.238 B 275.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7f7w TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8B99A O60674 536 809 1132.0 SKE:1003 Type1 Pseudo DFGin 5.8292 13.1897 None -69.78, 174.05 -70.57, 162.32 -72.88, -28.63 342.75, 30.69 79.14, -167.36 out-na out 11.6139 Saltbr-na 999.0 HRD-in -83.46, -62.07 90.64, -3.52 na-out-out SNCaoo out-out ActLoopNT-out 8.8443 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.87, -40.42 APE9-dihe-out -54.81, -33.54 APE8-dihe-out -85.07, 3.29 APE8-rot-na 283.44 APE67-dihe-out -103.17, 28.18 -66.12, 134.93 APE12-dist-na 9.7642 APE11-dist-na 11.3667 APE10-dist-na 15.959 APE9-dist-out 12.1602 W777A,F794H None None XRAY 1.6 0.19 0.211 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b99 TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8B9EA O60674 536 809 1132.0 Q7F:1003 Type1 Pseudo DFGin 5.7694 13.2256 None -72.27, 175.04 -67.31, 162.54 -76.41, -26.42 340.6, 33.67 78.05, -163.23 out-na out 11.7256 Saltbr-na 999.0 HRD-in -83.9, -60.17 88.41, -6.41 na-out-out SNCaoo out-out ActLoopNT-out 8.9495 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.18, -39.02 APE9-dihe-out -59.74, -28.13 APE8-dihe-out -86.36, 6.28 APE8-rot-na 284.57 APE67-dihe-out -105.41, 26.85 -68.63, 134.78 APE12-dist-na 9.6132 APE11-dist-na 11.3156 APE10-dist-na 15.8543 APE9-dist-out 12.1058 W777A,F794H None None XRAY 1.5 0.17 0.194 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9e TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8BABA O60674 536 809 1132.0 Q8N:908 Type1 Pseudo DFGin 5.7827 13.347 None -82.44, 178.74 -69.43, 159.24 -76.71, -21.64 341.13, 33.08 75.74, -169.92 out-na out 11.796 Saltbr-na 999.0 HRD-in -85.23, -57.58 89.38, -3.23 na-out-out SNCaoo out-out ActLoopNT-out 9.0793 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.14, -39.62 APE9-dihe-out -58.1, -35.37 APE8-dihe-out -80.74, 3.58 APE8-rot-na 288.39 APE67-dihe-out -100.89, 27.42 -62.52, 138.56 APE12-dist-na 9.8808 APE11-dist-na 11.4994 APE10-dist-na 16.1225 APE9-dist-out 12.5374 W777A,F794H None None XRAY 1.55 0.176 0.203 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8bab TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8BAKA O60674 536 809 1132.0 AD5:906 Type1 Pseudo DFGin 5.9 13.4848 None -79.74, 176.09 -70.26, 155.83 -67.8, -33.14 338.52, 35.12 82.51, -172.71 out-na out 11.7434 Saltbr-na 999.0 HRD-in -82.49, -60.1 89.16, -0.66 na-out-out SNCaoo out-out ActLoopNT-out 9.0218 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.79, -43.24 APE9-dihe-out -56.17, -32.1 APE8-dihe-out -84.4, 4.03 APE8-rot-na 284.51 APE67-dihe-out -100.67, 27.47 -64.95, 137.17 APE12-dist-na 9.8834 APE11-dist-na 11.5875 APE10-dist-na 16.1406 APE9-dist-out 12.6164 W777A,F794H None None XRAY 1.65 0.185 0.207 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8bak TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8C0AA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.565 13.3537 None -83.75, 166.81 -71.24, 158.41 -74.12, -10.51 25.45, 142.36 78.43, -168.66 in-na in 9.5594 Saltbr-na 999.0 HRD-in -83.22, -65.0 92.23, 1.81 na-out-out SNCaoo out-out ActLoopNT-out 9.6006 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -71.23, -34.89 APE9-dihe-out -65.21, -28.5 APE8-dihe-out -84.82, 8.34 APE8-rot-na 293.37 APE67-dihe-out -106.96, 23.1 -69.15, 131.91 APE12-dist-na 9.8924 APE11-dist-na 11.6237 APE10-dist-na 16.1468 APE9-dist-out 12.5708 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c0a TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8C0AB O60674 536 808 1132.0 T7I:902 Type1 Pseudo DFGin 7.4852 13.3983 None -84.77, 172.51 -72.53, 156.76 -75.35, -8.78 26.64, 140.87 71.28, -164.53 in-na in 9.8045 Saltbr-na 999.0 HRD-in -81.32, -65.94 88.05, 6.45 na-out-out SNCaoo out-out ActLoopNT-out 9.4136 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.73, -37.68 APE9-dihe-out -64.41, -27.87 APE8-dihe-out -85.03, 1.77 APE8-rot-na 284.08 APE67-dihe-out -105.43, 24.1 -65.54, 134.17 APE12-dist-na 9.7722 APE11-dist-na 11.4589 APE10-dist-na 16.0887 APE9-dist-out 12.4962 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 B 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c0a TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5WIJA O60674 536 809 1132.0 AQG:901 Type1 Pseudo DFGin 7.8557 13.5657 None -91.12, 177.94 -71.51, 155.95 -79.01, -8.25 29.98, 143.91 73.76, -166.11 in-na in 9.9173 Saltbr-na 999.0 HRD-in -72.47, -68.91 101.27, -5.66 na-out-out SNCaoo out-out ActLoopNT-out 9.3062 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.59, -26.98 APE9-dihe-out -64.74, -27.71 APE8-dihe-out -87.29, 3.84 APE8-rot-na 291.39 APE67-dihe-out -100.01, 30.88 -65.27, 134.93 APE12-dist-na 9.6175 APE11-dist-na 11.4946 APE10-dist-na 15.9937 APE9-dist-out 12.5098 W659A,W777A,F794H None None XRAY 2.04 0.209 0.231 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wij TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5WIKB O60674 536 809 1132.0 584:901 Type1 Pseudo DFGin 8.1996 13.4773 None -86.83, -177.1 -74.98, 154.5 -75.92, -8.34 30.63, 142.46 77.38, -163.2 out-na out 10.0153 Saltbr-na 999.0 HRD-in -75.13, -71.22 102.4, -1.09 na-out-out SNCaoo out-out ActLoopNT-out 9.4124 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.94, -26.86 APE9-dihe-out -70.71, -25.41 APE8-dihe-out -85.62, 4.24 APE8-rot-na 286.3 APE67-dihe-out -97.88, 28.27 -66.61, 137.0 APE12-dist-na 9.6629 APE11-dist-na 11.4185 APE10-dist-na 16.0555 APE9-dist-out 12.5943 W659A,W777A,F794H None None XRAY 2.6 0.211 0.251 B 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wik TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5WILA O60674 536 809 1132.0 YDJ:901 Type1 Pseudo DFGin 7.5307 13.7171 None -83.87, 163.34 -72.42, 163.18 -87.02, -3.44 24.44, 145.33 75.07, -167.72 out-na out 10.4597 Saltbr-na 999.0 HRD-in -86.92, -55.39 94.23, -3.93 na-out-out SNCaoo out-out ActLoopNT-out 9.6652 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.97, -30.77 APE9-dihe-out -75.41, -19.35 APE8-dihe-out -84.61, 10.2 APE8-rot-na 287.01 APE67-dihe-out -99.8, 25.99 -70.86, 137.89 APE12-dist-na 9.547 APE11-dist-na 11.4807 APE10-dist-na 16.0397 APE9-dist-out 12.6921 W659A,W777A,F794H None None XRAY 2.2 0.201 0.231 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wil TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5WIMA O60674 536 809 1132.0 35R:901 Type1 Pseudo DFGin 7.7523 13.5845 None -93.28, 176.5 -38.24, 151.14 -78.63, -21.68 29.2, 149.11 81.15, -169.97 out-na out 10.5675 Saltbr-na 999.0 HRD-in -83.09, -66.39 96.8, 0.86 na-out-out SNCaoo out-out ActLoopNT-out 9.8496 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -105.18, -10.47 APE9-dihe-out -83.98, -20.52 APE8-dihe-out -80.31, 9.26 APE8-rot-na 299.8 APE67-dihe-out -97.29, 28.98 -67.31, 132.23 APE12-dist-na 9.8326 APE11-dist-na 11.5419 APE10-dist-na 15.898 APE9-dist-out 12.8889 W659A,W777A,F794H None None XRAY 2.55 0.211 0.258 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wim TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5WINA O60674 536 809 1132.0 SKE:901 Type1 Pseudo DFGin 7.2805 13.7901 None -75.17, 174.41 -74.13, 155.6 -73.15, -17.87 26.75, 146.64 81.14, -159.91 out-na out 10.8153 Saltbr-na 999.0 HRD-in -80.84, -67.43 99.6, -2.16 na-out-out SNCaoo out-out ActLoopNT-out 9.5544 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -35.02 APE9-dihe-out -59.2, -25.51 APE8-dihe-out -88.93, -4.07 APE8-rot-na 287.0 APE67-dihe-out -96.98, 26.41 -56.71, 138.03 APE12-dist-na 9.5649 APE11-dist-na 11.6365 APE10-dist-na 16.0252 APE9-dist-out 12.3691 W659A,W777A,F794H None None XRAY 2.38 0.221 0.244 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5win TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5USZA O60674 537 808 1132.0 SKE:901 Type1 Pseudo DFGin 7.1469 13.1661 None -89.06, 179.4 -74.28, 155.49 -78.9, -12.42 30.8, 143.13 73.21, -171.41 in-na in 9.3491 Saltbr-na 999.0 HRD-in -84.39, -62.72 100.4, -8.06 na-out-out SNCaoo out-out ActLoopNT-out 9.8029 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.11, -40.08 APE9-dihe-out -63.02, -23.47 APE8-dihe-out -87.07, 3.62 APE8-rot-na 290.38 APE67-dihe-out -103.08, 29.45 -63.02, 136.82 APE12-dist-na 10.1185 APE11-dist-na 11.6069 APE10-dist-na 16.2335 APE9-dist-out 12.8894 W659A,W777A,F794H None None XRAY 2.103 0.174 0.224 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5usz TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5UT0A O60674 537 808 1132.0 35R:903 Type1 Pseudo DFGin 7.594 13.5715 None -93.9, 174.39 -69.93, 155.11 -74.3, -13.06 28.06, 143.5 77.21, -173.63 in-na in 9.9387 Saltbr-na 999.0 HRD-in -83.57, -61.23 99.02, -12.98 na-out-out SNCaoo out-out ActLoopNT-out 9.9661 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.47, -40.74 APE9-dihe-out -59.34, -26.03 APE8-dihe-out -86.35, 4.34 APE8-rot-na 287.5 APE67-dihe-out -101.06, 28.12 -64.23, 136.97 APE12-dist-na 10.0051 APE11-dist-na 11.4779 APE10-dist-na 16.1348 APE9-dist-out 12.9322 W659A,W777A,F794H None None XRAY 2.102 0.171 0.226 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut0 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5UT1A O60674 537 808 1132.0 7DZ:905 Type1 Pseudo DFGin 7.3785 13.4637 None -94.09, -179.69 -75.66, 158.87 -74.76, -6.96 27.15, 144.11 69.28, -174.72 in-na in 9.6956 Saltbr-na 999.0 HRD-in -82.87, -62.64 95.48, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.8118 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -38.46 APE9-dihe-out -62.2, -22.99 APE8-dihe-out -88.42, 4.71 APE8-rot-na 293.57 APE67-dihe-out -104.03, 27.01 -63.75, 135.14 APE12-dist-na 10.1099 APE11-dist-na 11.6437 APE10-dist-na 16.2104 APE9-dist-out 12.8829 W659A,W777A,F794H None None XRAY 1.95 0.165 0.202 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut1 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5UT2A O60674 536 808 1132.0 3YT:903 Type1 Pseudo DFGin 7.1266 13.3116 None -90.0, 179.18 -75.04, 157.7 -78.17, -8.03 29.61, 139.64 71.77, -178.13 in-na in 9.4878 Saltbr-na 999.0 HRD-in -87.63, -60.17 95.16, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.8702 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.9, -38.59 APE9-dihe-out -61.51, -24.95 APE8-dihe-out -88.74, 4.33 APE8-rot-na 288.64 APE67-dihe-out -101.61, 25.26 -63.02, 138.09 APE12-dist-na 10.0143 APE11-dist-na 11.5548 APE10-dist-na 16.1573 APE9-dist-out 12.8792 W659A,W777A,F794H None None XRAY 1.75 0.163 0.201 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut2 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5UT3A O60674 537 808 1132.0 IK1:901 Type1 Pseudo DFGin 7.2677 13.4017 None -92.6, 177.07 -71.65, 158.85 -79.65, -10.03 26.8, 143.01 73.38, -177.18 in-na in 9.6825 Saltbr-na 999.0 HRD-in -85.94, -61.54 97.51, -8.49 na-out-out SNCaoo out-out ActLoopNT-out 10.02 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.63, -39.44 APE9-dihe-out -66.05, -19.54 APE8-dihe-out -89.06, 2.9 APE8-rot-na 290.51 APE67-dihe-out -104.18, 27.32 -64.34, 136.22 APE12-dist-na 9.9898 APE11-dist-na 11.5779 APE10-dist-na 16.1923 APE9-dist-out 12.9958 W659A,W777A,F794H None None XRAY 1.501 0.156 0.17 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut3 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5UT4A O60674 537 809 1132.0 DQX:901 Type1 Pseudo DFGin 7.4596 13.2847 None -91.51, 174.25 -72.2, 155.17 -81.53, -6.98 30.25, 144.04 71.5, -173.67 in-na in 9.7389 Saltbr-na 999.0 HRD-in -82.44, -62.81 97.57, -6.96 na-out-out SNCaoo out-out ActLoopNT-out 9.5951 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.04, -37.57 APE9-dihe-out -62.17, -24.8 APE8-dihe-out -89.02, 2.73 APE8-rot-na 291.23 APE67-dihe-out -103.04, 31.05 -61.52, 137.36 APE12-dist-na 9.8738 APE11-dist-na 11.6283 APE10-dist-na 16.1461 APE9-dist-out 12.7464 W659A,W777A,F794H None None XRAY 2.0 0.18 0.22 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut4 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5UT5A O60674 537 808 1132.0 2HB:905 Type1 Pseudo DFGin 7.1887 13.2929 None -93.16, 174.58 -69.71, 153.91 -76.54, -10.06 29.7, 141.93 72.88, -178.86 in-na in 9.8227 Saltbr-na 999.0 HRD-in -86.78, -65.09 96.66, -4.13 na-out-out SNCaoo out-out ActLoopNT-out 9.8918 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.35, -36.77 APE9-dihe-out -64.06, -22.66 APE8-dihe-out -88.95, 4.87 APE8-rot-na 294.92 APE67-dihe-out -99.37, 27.39 -66.22, 138.89 APE12-dist-na 10.0661 APE11-dist-na 11.6537 APE10-dist-na 16.2639 APE9-dist-out 12.8254 W659A,W777A,F794H None None XRAY 1.9 0.162 0.201 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut5 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 5UT6A O60674 537 808 1132.0 8MY:901 Type1 Pseudo DFGin 7.8108 13.3833 None -94.36, -179.3 -74.79, 159.2 -78.43, -9.68 26.67, 142.51 69.48, -170.15 in-na in 9.7616 Saltbr-na 999.0 HRD-in -88.85, -58.65 93.81, -8.0 na-out-out SNCaoo out-out ActLoopNT-out 9.8903 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.58, -38.89 APE9-dihe-out -63.87, -22.26 APE8-dihe-out -88.04, 3.04 APE8-rot-na 294.63 APE67-dihe-out -105.83, 26.71 -62.56, 137.4 APE12-dist-na 10.0473 APE11-dist-na 11.6725 APE10-dist-na 16.2366 APE9-dist-out 13.0236 W659A,W777A,F794H None None XRAY 1.645 0.169 0.206 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut6 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6BRWA O60674 537 808 1132.0 5BS:901 Type1 Pseudo DFGin 7.7052 13.3794 None -93.41, 174.89 -67.04, 156.04 -83.01, 0.59 33.82, 139.96 67.03, -167.12 in-na in 9.6698 Saltbr-na 999.0 HRD-in -76.15, -62.39 95.18, -6.76 na-out-out SNCaoo out-out ActLoopNT-out 9.3464 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.9, -35.05 APE9-dihe-out -58.77, -25.82 APE8-dihe-out -90.17, 2.34 APE8-rot-na 284.96 APE67-dihe-out -99.82, 21.48 -62.86, 134.79 APE12-dist-na 9.9909 APE11-dist-na 11.5633 APE10-dist-na 16.1812 APE9-dist-out 12.8111 W659A,W777A,F794H None None XRAY 2.031 0.197 0.25 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6brw TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6BS0A O60674 537 808 1132.0 E4V:901 Type1 Pseudo DFGin 7.0805 13.2557 None -88.58, 177.61 -73.17, 156.09 -79.5, -8.28 28.34, 142.63 71.71, -176.36 in-na in 9.568 Saltbr-na 999.0 HRD-in -86.4, -62.0 95.3, -5.83 na-out-out SNCaoo out-out ActLoopNT-out 9.9043 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.75, -38.73 APE9-dihe-out -60.18, -24.31 APE8-dihe-out -91.13, 4.36 APE8-rot-na 292.13 APE67-dihe-out -103.61, 24.99 -63.19, 136.77 APE12-dist-na 10.05 APE11-dist-na 11.6293 APE10-dist-na 16.2311 APE9-dist-out 12.9298 W659A,W777A,F794H None None XRAY 1.541 0.162 0.195 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6bs0 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6BSSA O60674 537 808 1132.0 4SP:902 Type1 Pseudo DFGin 7.5682 13.5106 None -92.12, 176.26 -71.33, 155.06 -76.95, -9.06 29.95, 143.27 73.96, -170.06 in-na in 9.6875 Saltbr-na 999.0 HRD-in -85.06, -63.73 98.07, -5.96 na-out-out SNCaoo out-out ActLoopNT-out 9.8876 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.01, -35.23 APE9-dihe-out -61.99, -26.69 APE8-dihe-out -86.73, 3.75 APE8-rot-na 289.32 APE67-dihe-out -100.38, 23.52 -64.28, 136.45 APE12-dist-na 9.9849 APE11-dist-na 11.5508 APE10-dist-na 16.1873 APE9-dist-out 12.8821 W659A,W777A,F794H None None XRAY 2.1 0.194 0.235 A 289.0 271.0 1 24 24 0 [[545, 807], [849, 1125]] 2.0 6bss TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6M9HA O60674 536 808 1132.0 J9D:901 Type1 Pseudo DFGin 7.8658 13.1991 None -93.81, -179.33 -75.36, 156.59 -79.44, -11.27 28.67, 140.35 75.69, -170.14 in-na in 9.7885 Saltbr-na 999.0 HRD-in -82.1, -57.99 92.46, -9.79 na-out-out SNCaoo out-out ActLoopNT-out 9.792 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.63, -41.5 APE9-dihe-out -66.06, -19.63 APE8-dihe-out -87.45, 2.93 APE8-rot-na 291.17 APE67-dihe-out -101.95, 25.55 -63.43, 136.79 APE12-dist-na 10.0491 APE11-dist-na 11.5902 APE10-dist-na 16.2066 APE9-dist-out 12.9593 W659A,W777A,F794H None None XRAY 1.79 0.172 0.206 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6m9h TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6OAVA O60674 537 808 1132.0 M3A:901 Type1 Pseudo DFGin 7.1118 13.0392 None -89.82, 175.57 -71.85, 155.92 -76.93, -12.28 28.1, 145.13 74.45, -170.6 in-na in 9.8149 Saltbr-na 999.0 HRD-in -81.92, -60.26 97.52, -13.09 na-out-out SNCaoo out-out ActLoopNT-out 9.6491 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.27, -33.28 APE9-dihe-out -70.41, -15.65 APE8-dihe-out -94.12, 2.48 APE8-rot-na 295.49 APE67-dihe-out -103.53, 27.01 -62.67, 134.47 APE12-dist-na 9.9283 APE11-dist-na 11.4908 APE10-dist-na 16.0829 APE9-dist-out 12.7056 W659A,W777A,F794H None None XRAY 1.939 0.202 0.236 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6oav TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6OBBA O60674 537 808 1132.0 M3Y:901 Type1 Pseudo DFGin 7.3423 13.2339 None -84.34, 177.39 -74.24, 159.35 -79.81, -16.97 27.48, 144.61 78.13, -168.92 out-na out 10.1344 Saltbr-na 999.0 HRD-in -82.45, -60.11 93.59, -13.21 na-out-out SNCaoo out-out ActLoopNT-out 9.7343 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -38.37 APE9-dihe-out -67.29, -18.2 APE8-dihe-out -91.42, 5.55 APE8-rot-na 289.4 APE67-dihe-out -101.89, 28.31 -66.13, 136.22 APE12-dist-na 9.9763 APE11-dist-na 11.4381 APE10-dist-na 16.1001 APE9-dist-out 12.826 W659A,W777A,F794H None None XRAY 1.904 0.197 0.225 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obb TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6OBFA O60674 537 808 1132.0 M4G:902 Type1 Pseudo DFGin 5.8016 13.5747 None -75.4, 175.18 -69.61, 155.48 -61.14, -31.23 333.27, 38.74 78.42, -174.91 out-na out 11.7301 Saltbr-na 999.0 HRD-in -79.03, -58.03 90.73, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.1257 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.35, -37.95 APE9-dihe-out -66.08, -20.0 APE8-dihe-out -89.74, 3.4 APE8-rot-na 287.78 APE67-dihe-out -103.65, 28.29 -65.52, 135.12 APE12-dist-na 9.8761 APE11-dist-na 11.4144 APE10-dist-na 16.0183 APE9-dist-out 12.5198 W659A,W777A,F794H None None XRAY 1.71 0.199 0.222 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obf TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6OBLA O60674 537 808 1132.0 M4P:901 Type1 Pseudo DFGin 6.1314 13.618 None -84.06, 175.88 -72.71, 160.31 -68.63, -25.11 336.97, 36.63 73.61, -166.98 out-na out 11.5997 Saltbr-na 999.0 HRD-in -78.47, -60.55 94.84, -3.9 na-out-out SNCaoo out-out ActLoopNT-out 9.0751 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.59, -34.77 APE9-dihe-out -65.45, -25.46 APE8-dihe-out -86.12, 6.91 APE8-rot-na 289.77 APE67-dihe-out -101.28, 22.22 -64.94, 134.76 APE12-dist-na 9.8653 APE11-dist-na 11.3953 APE10-dist-na 16.0439 APE9-dist-out 12.7108 W659A,W777A,F794H None None XRAY 2.061 0.2 0.239 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obl TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6OCCA O60674 537 808 1132.0 M57:1002 Type1 Pseudo DFGin 6.0618 13.5692 None -84.33, 174.58 -71.42, 156.44 -66.05, -27.79 338.24, 34.72 78.91, -171.69 out-na out 11.7166 Saltbr-na 999.0 HRD-in -79.87, -63.55 97.41, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.2604 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.17, -40.0 APE9-dihe-out -66.58, -22.02 APE8-dihe-out -86.2, 2.55 APE8-rot-na 295.02 APE67-dihe-out -102.04, 27.42 -65.31, 136.06 APE12-dist-na 9.937 APE11-dist-na 11.4119 APE10-dist-na 16.0003 APE9-dist-out 12.4336 W659A,W777A,F794H None None XRAY 2.03 0.227 0.272 A 289.0 268.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6occ TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 6XJKA O60674 539 807 1132.0 V4D:901 Type1 Pseudo DFGin 7.0861 13.1101 None -82.39, -178.8 -73.6, 159.61 -82.47, -18.87 26.68, 148.75 79.98, -172.67 out-na out 10.9429 Saltbr-na 999.0 HRD-in -78.39, -61.79 94.59, -5.62 na-out-out SNCaoo out-out ActLoopNT-out 9.1768 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.63, -38.8 APE9-dihe-out -69.88, -19.28 APE8-dihe-out -90.06, 4.72 APE8-rot-na 291.97 APE67-dihe-out -100.24, 24.73 -62.96, 137.34 APE12-dist-na 9.833 APE11-dist-na 11.6512 APE10-dist-na 16.1346 APE9-dist-out 12.5371 W659A,W777A,F794H None None XRAY 2.024 0.229 0.273 A 289.0 265.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6xjk TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 7JYOA O60674 539 808 1132.0 VPS:901 Type1 Pseudo DFGin 7.3133 13.2651 None -88.9, -179.5 -76.4, 155.67 -78.17, -11.76 25.61, 146.28 75.85, -168.38 in-na in 9.9397 Saltbr-na 999.0 HRD-in -78.1, -62.53 100.04, -11.32 na-out-out SNCaoo out-out ActLoopNT-out 9.47 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.05, -35.44 APE9-dihe-out -67.28, -21.98 APE8-dihe-out -89.32, 5.73 APE8-rot-na 292.48 APE67-dihe-out -104.2, 24.04 -63.78, 134.25 APE12-dist-na 10.0063 APE11-dist-na 11.4947 APE10-dist-na 16.0721 APE9-dist-out 12.6709 W659A,W777A,F794H None None XRAY 2.161 0.188 0.246 A 289.0 270.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7jyo TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 7JYQA O60674 537 808 1132.0 VPJ:902 Type1 Pseudo DFGin 7.645 13.0055 None -92.98, -175.16 -77.54, 154.64 -78.8, -12.58 29.28, 143.4 74.39, -171.67 out-na out 13.0732 Saltbr-na 999.0 HRD-in -86.04, -59.14 96.24, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.8115 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.31, -38.61 APE9-dihe-out -62.73, -23.3 APE8-dihe-out -89.27, 2.43 APE8-rot-na 292.66 APE67-dihe-out -102.33, 26.3 -62.62, 135.22 APE12-dist-na 10.0152 APE11-dist-na 11.5681 APE10-dist-na 16.1683 APE9-dist-out 12.8664 W659A,W777A,F794H None None XRAY 1.859 0.181 0.221 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7jyq TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 7SZWA O60674 537 808 1132.0 DVY:901 Type1 Pseudo DFGin 6.4516 13.2599 None -82.57, 177.58 -73.21, 157.07 -69.74, -29.09 341.81, 33.15 77.93, -172.46 out-na out 12.3056 Saltbr-na 999.0 HRD-in -80.57, -59.83 95.34, -11.68 na-out-out SNCaoo out-out ActLoopNT-out 9.2552 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -37.85 APE9-dihe-out -63.74, -25.15 APE8-dihe-out -91.51, 8.03 APE8-rot-na 297.58 APE67-dihe-out -99.24, 24.79 -65.54, 137.42 APE12-dist-na 9.9259 APE11-dist-na 11.4265 APE10-dist-na 16.0645 APE9-dist-out 12.4083 W659A,W777A,F794H None None XRAY 1.906 0.195 0.226 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7szw TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 7T0PA O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.5356 13.4525 None -71.36, 169.62 -64.37, 154.19 -64.4, -34.91 335.03, 35.41 82.73, -164.25 out-na out 11.6251 Saltbr-na 999.0 HRD-in -78.49, -60.16 92.47, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.4113 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.7, -41.68 APE9-dihe-out -61.62, -27.73 APE8-dihe-out -89.13, 13.42 APE8-rot-na 292.46 APE67-dihe-out -104.69, 27.09 -67.15, 136.9 APE12-dist-na 10.1283 APE11-dist-na 11.4772 APE10-dist-na 16.1721 APE9-dist-out 12.8246 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t0p TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 7T0PB O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.5841 13.3753 None -73.4, 171.14 -67.99, 156.9 -65.04, -35.98 333.3, 36.74 84.58, -160.86 out-na out 11.6751 Saltbr-na 999.0 HRD-in -82.44, -59.87 91.7, -5.68 na-out-out SNCaoo out-out ActLoopNT-out 9.5252 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.77, -34.38 APE9-dihe-out -70.23, -20.91 APE8-dihe-out -95.01, 13.79 APE8-rot-na 294.77 APE67-dihe-out -106.03, 28.99 -67.37, 133.92 APE12-dist-na 10.0828 APE11-dist-na 11.624 APE10-dist-na 16.2602 APE9-dist-out 12.9567 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 B 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t0p TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 7T1TA O60674 536 809 1132.0 E8I:901 Type1 Pseudo DFGin 7.0745 13.1989 None -85.56, -179.34 -72.27, 154.59 -78.75, -8.81 22.02, 154.16 65.96, -165.49 out-na out 10.8121 Saltbr-na 999.0 HRD-in -83.69, -59.16 91.95, -7.4 na-out-out SNCaoo out-out ActLoopNT-out 9.7297 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.83, -40.65 APE9-dihe-out -65.84, -24.48 APE8-dihe-out -87.52, 8.41 APE8-rot-na 292.81 APE67-dihe-out -105.4, 28.45 -65.24, 133.84 APE12-dist-na 9.9478 APE11-dist-na 11.6118 APE10-dist-na 16.1823 APE9-dist-out 12.9375 W659A,W777A,F794H None None XRAY 2.08 0.183 0.228 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t1t TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8B9HA O60674 536 809 1132.0 Q7F:901 Type1 Pseudo DFGin 6.0102 13.3074 None -84.93, -177.89 -74.12, 157.3 -67.76, -31.57 343.4, 32.07 81.26, -168.8 out-na out 12.0967 Saltbr-na 999.0 HRD-in -82.25, -60.3 91.76, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 9.1429 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.85, -39.85 APE9-dihe-out -62.27, -26.85 APE8-dihe-out -86.04, 1.76 APE8-rot-na 292.25 APE67-dihe-out -100.68, 23.58 -62.84, 136.16 APE12-dist-na 9.712 APE11-dist-na 11.4338 APE10-dist-na 15.9334 APE9-dist-out 12.4277 W659A,W777A,F794H None None XRAY 1.5 0.182 0.208 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9h TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8BA3A O60674 536 812 1132.0 Q8U:60901 Type1 Pseudo DFGin 7.9449 13.7079 None -77.62, 172.89 -67.28, 156.81 -77.15, -9.78 24.71, 146.25 70.37, -168.01 out-na out 10.5812 Saltbr-na 999.0 HRD-in -73.02, -63.41 91.28, -5.41 na-out-out SNCaoo out-out ActLoopNT-out 8.8315 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.97, -37.88 APE9-dihe-out -69.87, -18.94 APE8-dihe-out -88.79, 5.92 APE8-rot-na 290.58 APE67-dihe-out -110.89, 28.54 -69.8, 129.69 APE12-dist-na 10.0415 APE11-dist-na 11.8896 APE10-dist-na 16.4253 APE9-dist-out 12.5092 W659A,W777A,F794H None None XRAY 1.4 0.175 0.197 A 289.0 277.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba3 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8EX0A O60674 536 808 1132.0 AQG:901 Type1 Pseudo DFGin 7.4123 13.4018 None -87.55, 174.91 -71.81, 159.18 -77.63, -11.45 24.29, 145.18 73.87, -172.91 in-na in 9.643 Saltbr-na 999.0 HRD-in -81.87, -61.41 94.19, -7.67 na-out-out SNCaoo out-out ActLoopNT-out 9.6084 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.42, -37.24 APE9-dihe-out -64.33, -22.0 APE8-dihe-out -89.33, 0.5 APE8-rot-na 287.44 APE67-dihe-out -103.06, 26.06 -59.07, 135.76 APE12-dist-na 9.8884 APE11-dist-na 11.5611 APE10-dist-na 16.1357 APE9-dist-out 12.686 W659A,W777A,F794H None None XRAY 1.85 0.179 0.228 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex0 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8EX1A O60674 537 808 1132.0 AD5:901 Type1 Pseudo DFGin 7.2822 13.5699 None -94.73, 174.88 -71.85, 156.73 -78.3, -7.64 23.96, 145.89 75.85, -176.26 in-na in 9.8513 Saltbr-na 999.0 HRD-in -83.17, -61.66 95.43, -4.68 na-out-out SNCaoo out-out ActLoopNT-out 9.7446 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.78, -38.61 APE9-dihe-out -63.17, -26.48 APE8-dihe-out -86.79, 6.17 APE8-rot-na 291.87 APE67-dihe-out -106.59, 26.74 -65.58, 134.04 APE12-dist-na 9.8512 APE11-dist-na 11.5504 APE10-dist-na 16.0568 APE9-dist-out 12.7733 W659A,W777A,F794H None None XRAY 1.5 0.169 0.191 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex1 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 8EX2A O60674 536 808 1132.0 Q2Q:901 Type1 Pseudo DFGin 7.6828 13.3897 None -89.91, 173.83 -74.44, 158.35 -75.25, -10.25 27.64, 142.49 74.64, -169.3 in-na in 9.7258 Saltbr-na 999.0 HRD-in -84.46, -65.65 96.23, -6.71 na-out-out SNCaoo out-out ActLoopNT-out 9.5614 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.11, -41.46 APE9-dihe-out -59.07, -26.71 APE8-dihe-out -87.22, 3.02 APE8-rot-na 287.18 APE67-dihe-out -104.5, 26.8 -63.95, 134.55 APE12-dist-na 9.9758 APE11-dist-na 11.51 APE10-dist-na 16.1308 APE9-dist-out 12.6339 W659A,W777A,F794H None None XRAY 1.9 0.172 0.203 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex2 TYR_JAK2-1_HUMAN TYR 2.7e-64 222.9 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 9ND5A O60674 536 809 1132.0 A1BXA:901 Type1 Pseudo DFGin 7.1967 13.4361 None -78.37, 174.28 -71.06, 155.85 -82.01, -13.03 28.16, 149.91 71.45, -157.96 out-na out 10.3765 Saltbr-na 999.0 HRD-in -81.65, -70.18 103.7, -2.47 na-out-out SNCaoo out-out ActLoopNT-out 9.4735 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -76.62, -29.08 APE9-dihe-out -76.41, -20.7 APE8-dihe-out -84.83, 10.94 APE8-rot-na 287.64 APE67-dihe-out -108.27, 36.81 -81.67, 130.11 APE12-dist-na 9.6535 APE11-dist-na 11.4413 APE10-dist-na 16.0178 APE9-dist-out 12.4531 None None None XRAY 2.4 0.214 0.278 A 280.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 9nd5 TYR_JAK2-1_HUMAN TYR 2.8e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 9ND3A O60674 536 808 1132.0 A1BW6:901 Type1 Pseudo DFGin 5.9957 13.1158 None -64.1, 173.67 -70.95, 163.72 -78.01, -24.74 341.83, 32.74 77.82, -165.18 out-na out 11.374 Saltbr-na 999.0 HRD-in -84.19, -60.63 89.29, -1.33 na-out-out SNCaoo out-out ActLoopNT-out 9.1954 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.37, -39.11 APE9-dihe-out -58.8, -29.7 APE8-dihe-out -87.32, 4.81 APE8-rot-na 289.91 APE67-dihe-out -104.68, 28.28 -65.86, 133.14 APE12-dist-na 9.6569 APE11-dist-na 11.4611 APE10-dist-na 16.0024 APE9-dist-out 12.276 None None None XRAY 1.62 0.189 0.22 A 283.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 9nd3 TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2

TYR_JAK2-1 (Tyrosine-protein kinase JAK2)

Total number of chains: 61
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 61 100.0% 8BA3A

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
JAK2-1 JAK2_HUMAN 5I4NA O60674 537 809 1132.0 ATP:61000 ATPlike Pseudo DFGin 5.6682 13.3858 None -68.19, 172.29 -64.41, 158.19 -73.31, -26.63 342.84, 34.8 77.82, -169.16 out-na out 11.405 Saltbr-na 999.0 HRD-in -78.6, -60.98 86.96, 3.87 na-out-out SNCaoo out-out ActLoopNT-out 8.6814 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.12, -41.49 APE9-dihe-out -58.18, -29.35 APE8-dihe-out -88.11, 6.74 APE8-rot-na 290.83 APE67-dihe-out -103.83, 26.01 -65.06, 135.53 APE12-dist-na 10.0371 APE11-dist-na 11.7 APE10-dist-na 16.2781 APE9-dist-out 12.3723 E596A,V617F,W659A,W777A,F794H None None XRAY 1.54 0.174 0.193 A 290.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5i4n Homo sapiens TYR_JAK2-1_HUMAN TYR 7.1e-64 221.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 4FVRA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 5.7656 13.3758 None -77.86, -178.54 -72.61, 163.95 -75.06, -27.39 334.11, 39.64 77.27, -166.65 out-na out 11.7821 Saltbr-na 999.0 HRD-in -74.66, -57.27 90.8, -3.55 na-out-out SNCaoo out-out ActLoopNT-out 8.5367 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.48, -33.68 APE9-dihe-out -63.8, -34.8 APE8-dihe-out -85.1, 11.44 APE8-rot-na 293.02 APE67-dihe-out -101.64, 24.24 -66.8, 135.55 APE12-dist-na 9.675 APE11-dist-na 11.4734 APE10-dist-na 16.0369 APE9-dist-out 12.0279 V617F,W777A,F794H None None XRAY 2.0 0.183 0.229 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvr Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 4FVQA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 6.4109 13.5312 None -82.38, -178.3 -71.29, 157.18 -64.23, -31.16 342.38, 32.32 77.45, -167.94 out-na out 10.3574 Saltbr-na 999.0 HRD-in -81.79, -59.57 93.66, -10.87 na-out-out SNCaoo out-out ActLoopNT-out 9.0941 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.14, -35.28 APE9-dihe-out -67.39, -22.98 APE8-dihe-out -92.26, 6.93 APE8-rot-na 290.03 APE67-dihe-out -106.47, 27.81 -64.4, 133.6 APE12-dist-na 9.9123 APE11-dist-na 11.4873 APE10-dist-na 16.0746 APE9-dist-out 12.3782 W659A,W777A,F794H None None XRAY 1.75 0.176 0.199 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvq Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8C08A O60674 537 810 1132.0 ATP:901 ATPlike Pseudo DFGin 6.5983 13.736 None -72.21, 176.69 -66.6, 164.57 -72.8, -15.2 349.18, 27.02 73.34, -163.25 in-na in 9.3998 Saltbr-na 999.0 HRD-in -80.72, -74.63 111.24, -16.83 na-out-out SNCaoo out-out ActLoopNT-out 9.4736 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.86, -37.52 APE9-dihe-out -72.05, -28.92 APE8-dihe-out -74.69, -10.21 APE8-rot-na 283.12 APE67-dihe-out -93.42, 18.23 -54.81, 139.34 APE12-dist-na 9.9203 APE11-dist-na 11.8594 APE10-dist-na 16.3524 APE9-dist-out 12.5304 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 A 289.0 270.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8C08B O60674 536 810 1132.0 ATP:901 ATPlike Pseudo DFGin 5.6459 13.5394 None -63.04, -178.12 -72.48, 164.14 -59.19, -39.37 337.51, 34.58 89.58, -173.09 out-na out 12.1784 Saltbr-na 999.0 HRD-in -76.08, -63.96 89.49, 0.26 na-out-out SNCaoo out-out ActLoopNT-out 8.7296 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.09, -36.29 APE9-dihe-out -67.21, -14.45 APE8-dihe-out -97.09, 0.9 APE8-rot-na 279.42 APE67-dihe-out -95.31, 21.21 -63.75, 135.54 APE12-dist-na 10.8478 APE11-dist-na 11.8372 APE10-dist-na 16.5999 APE9-dist-out 12.658 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 B 289.0 269.0 6 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8BA4B O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.0162 13.6285 None -84.33, -175.92 -78.92, 160.47 -67.97, -29.51 344.52, 29.43 84.02, -159.01 out-na out 10.5477 Saltbr-na 999.0 HRD-in -80.56, -60.88 93.85, -0.35 na-out-out SNCaoo out-out ActLoopNT-out 9.2529 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.77, -41.18 APE9-dihe-out -60.58, -30.76 APE8-dihe-out -85.29, 2.29 APE8-rot-na 288.75 APE67-dihe-out -100.46, 22.84 -59.03, 138.57 APE12-dist-na 9.6698 APE11-dist-na 11.3976 APE10-dist-na 15.9347 APE9-dist-out 12.6673 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 B 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba4 Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 4FVPA O60674 536 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.8931 13.0904 None -91.01, 179.45 -75.79, 153.56 -78.3, -11.29 26.93, 143.21 73.75, -158.65 out-na out 13.1657 Saltbr-na 999.0 HRD-in -83.21, -62.84 93.75, -4.6 na-out-out SNCaoo out-out ActLoopNT-out 9.629 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.0, -41.33 APE9-dihe-out -58.79, -30.31 APE8-dihe-out -86.85, 3.46 APE8-rot-na 297.22 APE67-dihe-out -102.61, 25.98 -63.62, 134.65 APE12-dist-na 9.8827 APE11-dist-na 11.6748 APE10-dist-na 16.1441 APE9-dist-out 12.5432 W659A,W777A,F794H None None XRAY 2.01 0.181 0.212 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvp Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8C09A O60674 538 809 1132.0 No_ligand No_ligand Pseudo DFGin 7.0525 13.2527 None -86.22, -176.26 -73.29, 161.33 -72.41, -30.09 344.35, 29.81 80.16, -162.74 out-na out 11.184 Saltbr-na 999.0 HRD-in -80.44, -66.09 97.2, -4.64 na-out-out SNCaoo out-out ActLoopNT-out 9.0791 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.51, -34.73 APE9-dihe-out -64.77, -31.42 APE8-dihe-out -84.71, 1.64 APE8-rot-na 292.35 APE67-dihe-out -99.58, 28.31 -60.08, 137.86 APE12-dist-na 9.8638 APE11-dist-na 11.5573 APE10-dist-na 16.1216 APE9-dist-out 12.4835 I559F,W659A,W777A,F794H None None XRAY 1.9 0.223 0.257 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c09 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.3e-63 220.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6G3CA O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.9293 13.2972 None -92.88, -174.23 -74.55, 160.0 -77.81, -9.76 27.51, 143.79 70.13, -167.0 in-na in 9.4623 Saltbr-na 999.0 HRD-in -89.47, -61.45 91.27, -4.79 na-out-out SNCaoo out-out ActLoopNT-out 9.753 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.76, -39.79 APE9-dihe-out -61.91, -29.13 APE8-dihe-out -80.12, 0.2 APE8-rot-na 289.19 APE67-dihe-out -101.75, 22.48 -69.62, 136.72 APE12-dist-na 9.7666 APE11-dist-na 11.5665 APE10-dist-na 16.1545 APE9-dist-out 12.7021 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 A 272.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6g3c Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6G3CB O60674 537 808 1132.0 EKT:901 Type1 Pseudo DFGin 7.9902 13.415 None -91.77, -175.11 -73.45, 159.45 -76.52, -11.86 28.49, 143.52 73.41, -164.04 in-na in 9.643 Saltbr-na 999.0 HRD-in -89.94, -61.82 90.1, -3.95 na-out-out SNCaoo out-out ActLoopNT-out 9.6929 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.88, -39.41 APE9-dihe-out -62.88, -28.18 APE8-dihe-out -81.21, 1.24 APE8-rot-na 288.18 APE67-dihe-out -102.69, 23.29 -70.43, 136.03 APE12-dist-na 9.7694 APE11-dist-na 11.5802 APE10-dist-na 16.1381 APE9-dist-out 12.6902 W659A,W777A,F794H None None XRAY 1.6 0.196 0.22 B 272.0 268.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6g3c Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6D2IA O60674 536 808 1132.0 35R:901 Type1 Pseudo DFGin 6.5522 13.6514 None -85.6, -168.64 -71.02, 159.25 -67.8, -19.61 341.93, 32.5 72.61, -145.53 in-na in 9.6393 Saltbr-na 999.0 HRD-in -88.15, -70.56 100.36, -8.76 na-out-out SNCaoo out-out ActLoopNT-out 9.7002 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.19, -30.63 APE9-dihe-out -73.76, -13.56 APE8-dihe-out -89.52, 2.58 APE8-rot-na 300.29 APE67-dihe-out -99.98, 28.53 -66.76, 135.82 APE12-dist-na 10.5196 APE11-dist-na 11.5137 APE10-dist-na 16.3152 APE9-dist-out 13.0189 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 A 273.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6D2IB O60674 537 808 1132.0 35R:901 Type1 Pseudo DFGin 6.7449 13.508 None -83.97, -172.62 -69.78, 158.02 -65.46, -20.62 341.26, 32.34 71.79, -145.54 in-na in 9.4363 Saltbr-na 999.0 HRD-in -84.58, -69.97 97.0, -6.55 na-out-out SNCaoo out-out ActLoopNT-out 9.4489 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.97, -30.79 APE9-dihe-out -72.59, -17.09 APE8-dihe-out -89.77, 2.61 APE8-rot-na 301.92 APE67-dihe-out -99.31, 27.86 -67.19, 135.78 APE12-dist-na 10.5863 APE11-dist-na 11.8904 APE10-dist-na 16.6501 APE9-dist-out 12.8955 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 B 273.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8B8NA O60674 536 809 1132.0 AQG:904 Type1 Pseudo DFGin 6.9922 13.5588 None -86.6, 176.83 -72.07, 163.0 -83.55, -11.71 8.83, 7.64 73.11, -166.45 out-na out 10.2232 Saltbr-na 999.0 HRD-in -77.47, -60.54 92.78, -1.1 na-out-out SNCaoo out-out ActLoopNT-out 9.2549 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.27, -38.06 APE9-dihe-out -61.66, -30.26 APE8-dihe-out -80.2, 3.05 APE8-rot-na 289.81 APE67-dihe-out -99.17, 33.25 -63.6, 138.44 APE12-dist-na 9.5537 APE11-dist-na 11.4484 APE10-dist-na 15.9705 APE9-dist-out 12.4531 W659A,W777A,F794H None None XRAY 2.0 0.211 0.255 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8n Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8B8UA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.821 13.2982 None -86.5, 168.2 -72.83, 159.81 -77.39, -5.69 29.32, 142.66 68.85, -165.5 in-na in 9.6368 Saltbr-na 999.0 HRD-in -85.53, -63.36 91.05, -0.77 na-out-out SNCaoo out-out ActLoopNT-out 9.5857 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -40.18 APE9-dihe-out -60.78, -27.05 APE8-dihe-out -85.5, 2.2 APE8-rot-na 288.85 APE67-dihe-out -105.88, 26.49 -64.53, 136.9 APE12-dist-na 9.8393 APE11-dist-na 11.5435 APE10-dist-na 16.1353 APE9-dist-out 12.651 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8u Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8B8UB O60674 538 809 1132.0 T7I:903 Type1 Pseudo DFGin 7.6842 13.3671 None -85.95, 172.23 -73.23, 159.57 -79.19, -7.74 28.18, 144.77 71.86, -165.96 in-na in 9.8706 Saltbr-na 999.0 HRD-in -85.44, -62.47 91.56, -1.37 na-out-out SNCaoo out-out ActLoopNT-out 9.4049 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.42, -39.8 APE9-dihe-out -61.59, -26.48 APE8-dihe-out -85.69, -0.76 APE8-rot-na 289.8 APE67-dihe-out -104.95, 23.87 -61.36, 134.02 APE12-dist-na 9.8928 APE11-dist-na 11.4874 APE10-dist-na 16.1064 APE9-dist-out 12.5476 W659A,W777A,F794H None None XRAY 1.5 0.224 0.259 B 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b8u Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8BA2A O60674 536 810 1132.0 Q9X:907 Type1 Pseudo DFGin 5.7073 13.2724 None -74.82, 174.75 -67.11, 161.11 -77.71, -21.19 340.67, 34.41 73.6, -166.64 out-na out 11.6572 Saltbr-na 999.0 HRD-in -83.09, -59.59 87.04, -0.99 na-out-out SNCaoo out-out ActLoopNT-out 8.9491 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.59, -40.16 APE9-dihe-out -57.17, -31.99 APE8-dihe-out -85.57, 4.75 APE8-rot-na 288.77 APE67-dihe-out -102.79, 29.41 -64.21, 136.1 APE12-dist-na 9.7351 APE11-dist-na 11.4317 APE10-dist-na 16.0182 APE9-dist-out 12.2832 W659A,W777A,F794H None None XRAY 1.5 0.178 0.204 A 289.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba2 Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8BA4A O60674 536 809 1132.0 Q8U:901 Type1 Pseudo DFGin 7.9438 13.4117 None -71.69, 172.79 -67.86, 161.07 -79.48, -19.97 29.54, 146.52 81.3, -166.68 in-na in 9.7879 Saltbr-na 999.0 HRD-in -74.34, -63.4 91.62, 2.89 na-out-out SNCaoo out-out ActLoopNT-out 8.5896 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.98, -39.28 APE9-dihe-out -56.91, -30.54 APE8-dihe-out -86.08, -1.03 APE8-rot-na 290.49 APE67-dihe-out -99.32, 21.83 -60.56, 137.6 APE12-dist-na 9.9255 APE11-dist-na 11.6473 APE10-dist-na 16.1443 APE9-dist-out 12.3271 W659A,W777A,F794H None None XRAY 2.1 0.219 0.274 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba4 Homo sapiens TYR_JAK2-1_HUMAN TYR 3.7e-64 222.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 7F7WA O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.915 13.7962 None -91.54, 171.73 -67.57, 155.24 -69.34, -22.33 351.29, 21.05 78.83, -168.1 out-na out 10.1693 Saltbr-na 999.0 HRD-in -84.02, -62.23 90.48, 0.05 na-out-out SNCaoo out-out ActLoopNT-out 9.7232 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.04, -35.76 APE9-dihe-out -66.77, -25.16 APE8-dihe-out -85.21, 3.67 APE8-rot-na 284.34 APE67-dihe-out -100.56, 25.85 -66.38, 135.35 APE12-dist-na 9.6893 APE11-dist-na 11.4731 APE10-dist-na 16.0322 APE9-dist-out 12.6531 None None None XRAY 1.83 0.208 0.238 A 275.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7f7w Homo sapiens TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 7F7WB O60674 536 810 1132.0 36H:1000 Type1 Pseudo DFGin 6.9033 13.6869 None -84.95, 175.07 -74.42, 156.63 -70.62, -23.21 351.87, 21.25 77.0, -167.15 out-na out 10.2517 Saltbr-na 999.0 HRD-in -79.03, -66.0 95.6, -1.12 na-out-out SNCaoo out-out ActLoopNT-out 9.4951 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.33, -37.68 APE9-dihe-out -69.53, -21.97 APE8-dihe-out -87.12, 4.19 APE8-rot-na 285.11 APE67-dihe-out -99.09, 24.95 -67.63, 136.04 APE12-dist-na 9.7044 APE11-dist-na 11.4907 APE10-dist-na 16.0173 APE9-dist-out 12.671 None None None XRAY 1.83 0.208 0.238 B 275.0 275.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7f7w Homo sapiens TYR_JAK2-1_HUMAN TYR 5.3e-64 222.0 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8B99A O60674 536 809 1132.0 SKE:1003 Type1 Pseudo DFGin 5.8292 13.1897 None -69.78, 174.05 -70.57, 162.32 -72.88, -28.63 342.75, 30.69 79.14, -167.36 out-na out 11.6139 Saltbr-na 999.0 HRD-in -83.46, -62.07 90.64, -3.52 na-out-out SNCaoo out-out ActLoopNT-out 8.8443 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.87, -40.42 APE9-dihe-out -54.81, -33.54 APE8-dihe-out -85.07, 3.29 APE8-rot-na 283.44 APE67-dihe-out -103.17, 28.18 -66.12, 134.93 APE12-dist-na 9.7642 APE11-dist-na 11.3667 APE10-dist-na 15.959 APE9-dist-out 12.1602 W777A,F794H None None XRAY 1.6 0.19 0.211 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b99 Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8B9EA O60674 536 809 1132.0 Q7F:1003 Type1 Pseudo DFGin 5.7694 13.2256 None -72.27, 175.04 -67.31, 162.54 -76.41, -26.42 340.6, 33.67 78.05, -163.23 out-na out 11.7256 Saltbr-na 999.0 HRD-in -83.9, -60.17 88.41, -6.41 na-out-out SNCaoo out-out ActLoopNT-out 8.9495 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.18, -39.02 APE9-dihe-out -59.74, -28.13 APE8-dihe-out -86.36, 6.28 APE8-rot-na 284.57 APE67-dihe-out -105.41, 26.85 -68.63, 134.78 APE12-dist-na 9.6132 APE11-dist-na 11.3156 APE10-dist-na 15.8543 APE9-dist-out 12.1058 W777A,F794H None None XRAY 1.5 0.17 0.194 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9e Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8BABA O60674 536 809 1132.0 Q8N:908 Type1 Pseudo DFGin 5.7827 13.347 None -82.44, 178.74 -69.43, 159.24 -76.71, -21.64 341.13, 33.08 75.74, -169.92 out-na out 11.796 Saltbr-na 999.0 HRD-in -85.23, -57.58 89.38, -3.23 na-out-out SNCaoo out-out ActLoopNT-out 9.0793 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.14, -39.62 APE9-dihe-out -58.1, -35.37 APE8-dihe-out -80.74, 3.58 APE8-rot-na 288.39 APE67-dihe-out -100.89, 27.42 -62.52, 138.56 APE12-dist-na 9.8808 APE11-dist-na 11.4994 APE10-dist-na 16.1225 APE9-dist-out 12.5374 W777A,F794H None None XRAY 1.55 0.176 0.203 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8bab Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8BAKA O60674 536 809 1132.0 AD5:906 Type1 Pseudo DFGin 5.9 13.4848 None -79.74, 176.09 -70.26, 155.83 -67.8, -33.14 338.52, 35.12 82.51, -172.71 out-na out 11.7434 Saltbr-na 999.0 HRD-in -82.49, -60.1 89.16, -0.66 na-out-out SNCaoo out-out ActLoopNT-out 9.0218 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.79, -43.24 APE9-dihe-out -56.17, -32.1 APE8-dihe-out -84.4, 4.03 APE8-rot-na 284.51 APE67-dihe-out -100.67, 27.47 -64.95, 137.17 APE12-dist-na 9.8834 APE11-dist-na 11.5875 APE10-dist-na 16.1406 APE9-dist-out 12.6164 W777A,F794H None None XRAY 1.65 0.185 0.207 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8bak Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8C0AA O60674 536 809 1132.0 T7I:902 Type1 Pseudo DFGin 7.565 13.3537 None -83.75, 166.81 -71.24, 158.41 -74.12, -10.51 25.45, 142.36 78.43, -168.66 in-na in 9.5594 Saltbr-na 999.0 HRD-in -83.22, -65.0 92.23, 1.81 na-out-out SNCaoo out-out ActLoopNT-out 9.6006 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -71.23, -34.89 APE9-dihe-out -65.21, -28.5 APE8-dihe-out -84.82, 8.34 APE8-rot-na 293.37 APE67-dihe-out -106.96, 23.1 -69.15, 131.91 APE12-dist-na 9.8924 APE11-dist-na 11.6237 APE10-dist-na 16.1468 APE9-dist-out 12.5708 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c0a Homo sapiens TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8C0AB O60674 536 808 1132.0 T7I:902 Type1 Pseudo DFGin 7.4852 13.3983 None -84.77, 172.51 -72.53, 156.76 -75.35, -8.78 26.64, 140.87 71.28, -164.53 in-na in 9.8045 Saltbr-na 999.0 HRD-in -81.32, -65.94 88.05, 6.45 na-out-out SNCaoo out-out ActLoopNT-out 9.4136 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.73, -37.68 APE9-dihe-out -64.41, -27.87 APE8-dihe-out -85.03, 1.77 APE8-rot-na 284.08 APE67-dihe-out -105.43, 24.1 -65.54, 134.17 APE12-dist-na 9.7722 APE11-dist-na 11.4589 APE10-dist-na 16.0887 APE9-dist-out 12.4962 W659A,R683S,W777A,F794H None None XRAY 1.7 0.196 0.237 B 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8c0a Homo sapiens TYR_JAK2-1_HUMAN TYR 1.5e-64 223.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5WIJA O60674 536 809 1132.0 AQG:901 Type1 Pseudo DFGin 7.8557 13.5657 None -91.12, 177.94 -71.51, 155.95 -79.01, -8.25 29.98, 143.91 73.76, -166.11 in-na in 9.9173 Saltbr-na 999.0 HRD-in -72.47, -68.91 101.27, -5.66 na-out-out SNCaoo out-out ActLoopNT-out 9.3062 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.59, -26.98 APE9-dihe-out -64.74, -27.71 APE8-dihe-out -87.29, 3.84 APE8-rot-na 291.39 APE67-dihe-out -100.01, 30.88 -65.27, 134.93 APE12-dist-na 9.6175 APE11-dist-na 11.4946 APE10-dist-na 15.9937 APE9-dist-out 12.5098 W659A,W777A,F794H None None XRAY 2.04 0.209 0.231 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wij Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5WIKB O60674 536 809 1132.0 584:901 Type1 Pseudo DFGin 8.1996 13.4773 None -86.83, -177.1 -74.98, 154.5 -75.92, -8.34 30.63, 142.46 77.38, -163.2 out-na out 10.0153 Saltbr-na 999.0 HRD-in -75.13, -71.22 102.4, -1.09 na-out-out SNCaoo out-out ActLoopNT-out 9.4124 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.94, -26.86 APE9-dihe-out -70.71, -25.41 APE8-dihe-out -85.62, 4.24 APE8-rot-na 286.3 APE67-dihe-out -97.88, 28.27 -66.61, 137.0 APE12-dist-na 9.6629 APE11-dist-na 11.4185 APE10-dist-na 16.0555 APE9-dist-out 12.5943 W659A,W777A,F794H None None XRAY 2.6 0.211 0.251 B 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wik Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5WILA O60674 536 809 1132.0 YDJ:901 Type1 Pseudo DFGin 7.5307 13.7171 None -83.87, 163.34 -72.42, 163.18 -87.02, -3.44 24.44, 145.33 75.07, -167.72 out-na out 10.4597 Saltbr-na 999.0 HRD-in -86.92, -55.39 94.23, -3.93 na-out-out SNCaoo out-out ActLoopNT-out 9.6652 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.97, -30.77 APE9-dihe-out -75.41, -19.35 APE8-dihe-out -84.61, 10.2 APE8-rot-na 287.01 APE67-dihe-out -99.8, 25.99 -70.86, 137.89 APE12-dist-na 9.547 APE11-dist-na 11.4807 APE10-dist-na 16.0397 APE9-dist-out 12.6921 W659A,W777A,F794H None None XRAY 2.2 0.201 0.231 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wil Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5WIMA O60674 536 809 1132.0 35R:901 Type1 Pseudo DFGin 7.7523 13.5845 None -93.28, 176.5 -38.24, 151.14 -78.63, -21.68 29.2, 149.11 81.15, -169.97 out-na out 10.5675 Saltbr-na 999.0 HRD-in -83.09, -66.39 96.8, 0.86 na-out-out SNCaoo out-out ActLoopNT-out 9.8496 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -105.18, -10.47 APE9-dihe-out -83.98, -20.52 APE8-dihe-out -80.31, 9.26 APE8-rot-na 299.8 APE67-dihe-out -97.29, 28.98 -67.31, 132.23 APE12-dist-na 9.8326 APE11-dist-na 11.5419 APE10-dist-na 15.898 APE9-dist-out 12.8889 W659A,W777A,F794H None None XRAY 2.55 0.211 0.258 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wim Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5WINA O60674 536 809 1132.0 SKE:901 Type1 Pseudo DFGin 7.2805 13.7901 None -75.17, 174.41 -74.13, 155.6 -73.15, -17.87 26.75, 146.64 81.14, -159.91 out-na out 10.8153 Saltbr-na 999.0 HRD-in -80.84, -67.43 99.6, -2.16 na-out-out SNCaoo out-out ActLoopNT-out 9.5544 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -35.02 APE9-dihe-out -59.2, -25.51 APE8-dihe-out -88.93, -4.07 APE8-rot-na 287.0 APE67-dihe-out -96.98, 26.41 -56.71, 138.03 APE12-dist-na 9.5649 APE11-dist-na 11.6365 APE10-dist-na 16.0252 APE9-dist-out 12.3691 W659A,W777A,F794H None None XRAY 2.38 0.221 0.244 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5win Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5USZA O60674 537 808 1132.0 SKE:901 Type1 Pseudo DFGin 7.1469 13.1661 None -89.06, 179.4 -74.28, 155.49 -78.9, -12.42 30.8, 143.13 73.21, -171.41 in-na in 9.3491 Saltbr-na 999.0 HRD-in -84.39, -62.72 100.4, -8.06 na-out-out SNCaoo out-out ActLoopNT-out 9.8029 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.11, -40.08 APE9-dihe-out -63.02, -23.47 APE8-dihe-out -87.07, 3.62 APE8-rot-na 290.38 APE67-dihe-out -103.08, 29.45 -63.02, 136.82 APE12-dist-na 10.1185 APE11-dist-na 11.6069 APE10-dist-na 16.2335 APE9-dist-out 12.8894 W659A,W777A,F794H None None XRAY 2.103 0.174 0.224 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5usz Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5UT0A O60674 537 808 1132.0 35R:903 Type1 Pseudo DFGin 7.594 13.5715 None -93.9, 174.39 -69.93, 155.11 -74.3, -13.06 28.06, 143.5 77.21, -173.63 in-na in 9.9387 Saltbr-na 999.0 HRD-in -83.57, -61.23 99.02, -12.98 na-out-out SNCaoo out-out ActLoopNT-out 9.9661 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.47, -40.74 APE9-dihe-out -59.34, -26.03 APE8-dihe-out -86.35, 4.34 APE8-rot-na 287.5 APE67-dihe-out -101.06, 28.12 -64.23, 136.97 APE12-dist-na 10.0051 APE11-dist-na 11.4779 APE10-dist-na 16.1348 APE9-dist-out 12.9322 W659A,W777A,F794H None None XRAY 2.102 0.171 0.226 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut0 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5UT1A O60674 537 808 1132.0 7DZ:905 Type1 Pseudo DFGin 7.3785 13.4637 None -94.09, -179.69 -75.66, 158.87 -74.76, -6.96 27.15, 144.11 69.28, -174.72 in-na in 9.6956 Saltbr-na 999.0 HRD-in -82.87, -62.64 95.48, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.8118 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.26, -38.46 APE9-dihe-out -62.2, -22.99 APE8-dihe-out -88.42, 4.71 APE8-rot-na 293.57 APE67-dihe-out -104.03, 27.01 -63.75, 135.14 APE12-dist-na 10.1099 APE11-dist-na 11.6437 APE10-dist-na 16.2104 APE9-dist-out 12.8829 W659A,W777A,F794H None None XRAY 1.95 0.165 0.202 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut1 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5UT2A O60674 536 808 1132.0 3YT:903 Type1 Pseudo DFGin 7.1266 13.3116 None -90.0, 179.18 -75.04, 157.7 -78.17, -8.03 29.61, 139.64 71.77, -178.13 in-na in 9.4878 Saltbr-na 999.0 HRD-in -87.63, -60.17 95.16, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.8702 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.9, -38.59 APE9-dihe-out -61.51, -24.95 APE8-dihe-out -88.74, 4.33 APE8-rot-na 288.64 APE67-dihe-out -101.61, 25.26 -63.02, 138.09 APE12-dist-na 10.0143 APE11-dist-na 11.5548 APE10-dist-na 16.1573 APE9-dist-out 12.8792 W659A,W777A,F794H None None XRAY 1.75 0.163 0.201 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut2 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5UT3A O60674 537 808 1132.0 IK1:901 Type1 Pseudo DFGin 7.2677 13.4017 None -92.6, 177.07 -71.65, 158.85 -79.65, -10.03 26.8, 143.01 73.38, -177.18 in-na in 9.6825 Saltbr-na 999.0 HRD-in -85.94, -61.54 97.51, -8.49 na-out-out SNCaoo out-out ActLoopNT-out 10.02 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.63, -39.44 APE9-dihe-out -66.05, -19.54 APE8-dihe-out -89.06, 2.9 APE8-rot-na 290.51 APE67-dihe-out -104.18, 27.32 -64.34, 136.22 APE12-dist-na 9.9898 APE11-dist-na 11.5779 APE10-dist-na 16.1923 APE9-dist-out 12.9958 W659A,W777A,F794H None None XRAY 1.501 0.156 0.17 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut3 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5UT4A O60674 537 809 1132.0 DQX:901 Type1 Pseudo DFGin 7.4596 13.2847 None -91.51, 174.25 -72.2, 155.17 -81.53, -6.98 30.25, 144.04 71.5, -173.67 in-na in 9.7389 Saltbr-na 999.0 HRD-in -82.44, -62.81 97.57, -6.96 na-out-out SNCaoo out-out ActLoopNT-out 9.5951 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.04, -37.57 APE9-dihe-out -62.17, -24.8 APE8-dihe-out -89.02, 2.73 APE8-rot-na 291.23 APE67-dihe-out -103.04, 31.05 -61.52, 137.36 APE12-dist-na 9.8738 APE11-dist-na 11.6283 APE10-dist-na 16.1461 APE9-dist-out 12.7464 W659A,W777A,F794H None None XRAY 2.0 0.18 0.22 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut4 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5UT5A O60674 537 808 1132.0 2HB:905 Type1 Pseudo DFGin 7.1887 13.2929 None -93.16, 174.58 -69.71, 153.91 -76.54, -10.06 29.7, 141.93 72.88, -178.86 in-na in 9.8227 Saltbr-na 999.0 HRD-in -86.78, -65.09 96.66, -4.13 na-out-out SNCaoo out-out ActLoopNT-out 9.8918 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.35, -36.77 APE9-dihe-out -64.06, -22.66 APE8-dihe-out -88.95, 4.87 APE8-rot-na 294.92 APE67-dihe-out -99.37, 27.39 -66.22, 138.89 APE12-dist-na 10.0661 APE11-dist-na 11.6537 APE10-dist-na 16.2639 APE9-dist-out 12.8254 W659A,W777A,F794H None None XRAY 1.9 0.162 0.201 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut5 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 5UT6A O60674 537 808 1132.0 8MY:901 Type1 Pseudo DFGin 7.8108 13.3833 None -94.36, -179.3 -74.79, 159.2 -78.43, -9.68 26.67, 142.51 69.48, -170.15 in-na in 9.7616 Saltbr-na 999.0 HRD-in -88.85, -58.65 93.81, -8.0 na-out-out SNCaoo out-out ActLoopNT-out 9.8903 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.58, -38.89 APE9-dihe-out -63.87, -22.26 APE8-dihe-out -88.04, 3.04 APE8-rot-na 294.63 APE67-dihe-out -105.83, 26.71 -62.56, 137.4 APE12-dist-na 10.0473 APE11-dist-na 11.6725 APE10-dist-na 16.2366 APE9-dist-out 13.0236 W659A,W777A,F794H None None XRAY 1.645 0.169 0.206 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut6 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6BRWA O60674 537 808 1132.0 5BS:901 Type1 Pseudo DFGin 7.7052 13.3794 None -93.41, 174.89 -67.04, 156.04 -83.01, 0.59 33.82, 139.96 67.03, -167.12 in-na in 9.6698 Saltbr-na 999.0 HRD-in -76.15, -62.39 95.18, -6.76 na-out-out SNCaoo out-out ActLoopNT-out 9.3464 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -74.9, -35.05 APE9-dihe-out -58.77, -25.82 APE8-dihe-out -90.17, 2.34 APE8-rot-na 284.96 APE67-dihe-out -99.82, 21.48 -62.86, 134.79 APE12-dist-na 9.9909 APE11-dist-na 11.5633 APE10-dist-na 16.1812 APE9-dist-out 12.8111 W659A,W777A,F794H None None XRAY 2.031 0.197 0.25 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6brw Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6BS0A O60674 537 808 1132.0 E4V:901 Type1 Pseudo DFGin 7.0805 13.2557 None -88.58, 177.61 -73.17, 156.09 -79.5, -8.28 28.34, 142.63 71.71, -176.36 in-na in 9.568 Saltbr-na 999.0 HRD-in -86.4, -62.0 95.3, -5.83 na-out-out SNCaoo out-out ActLoopNT-out 9.9043 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.75, -38.73 APE9-dihe-out -60.18, -24.31 APE8-dihe-out -91.13, 4.36 APE8-rot-na 292.13 APE67-dihe-out -103.61, 24.99 -63.19, 136.77 APE12-dist-na 10.05 APE11-dist-na 11.6293 APE10-dist-na 16.2311 APE9-dist-out 12.9298 W659A,W777A,F794H None None XRAY 1.541 0.162 0.195 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6bs0 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6BSSA O60674 537 808 1132.0 4SP:902 Type1 Pseudo DFGin 7.5682 13.5106 None -92.12, 176.26 -71.33, 155.06 -76.95, -9.06 29.95, 143.27 73.96, -170.06 in-na in 9.6875 Saltbr-na 999.0 HRD-in -85.06, -63.73 98.07, -5.96 na-out-out SNCaoo out-out ActLoopNT-out 9.8876 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.01, -35.23 APE9-dihe-out -61.99, -26.69 APE8-dihe-out -86.73, 3.75 APE8-rot-na 289.32 APE67-dihe-out -100.38, 23.52 -64.28, 136.45 APE12-dist-na 9.9849 APE11-dist-na 11.5508 APE10-dist-na 16.1873 APE9-dist-out 12.8821 W659A,W777A,F794H None None XRAY 2.1 0.194 0.235 A 289.0 271.0 1 24 24 0 [[545, 807], [849, 1125]] 2.0 6bss Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6M9HA O60674 536 808 1132.0 J9D:901 Type1 Pseudo DFGin 7.8658 13.1991 None -93.81, -179.33 -75.36, 156.59 -79.44, -11.27 28.67, 140.35 75.69, -170.14 in-na in 9.7885 Saltbr-na 999.0 HRD-in -82.1, -57.99 92.46, -9.79 na-out-out SNCaoo out-out ActLoopNT-out 9.792 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.63, -41.5 APE9-dihe-out -66.06, -19.63 APE8-dihe-out -87.45, 2.93 APE8-rot-na 291.17 APE67-dihe-out -101.95, 25.55 -63.43, 136.79 APE12-dist-na 10.0491 APE11-dist-na 11.5902 APE10-dist-na 16.2066 APE9-dist-out 12.9593 W659A,W777A,F794H None None XRAY 1.79 0.172 0.206 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6m9h Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6OAVA O60674 537 808 1132.0 M3A:901 Type1 Pseudo DFGin 7.1118 13.0392 None -89.82, 175.57 -71.85, 155.92 -76.93, -12.28 28.1, 145.13 74.45, -170.6 in-na in 9.8149 Saltbr-na 999.0 HRD-in -81.92, -60.26 97.52, -13.09 na-out-out SNCaoo out-out ActLoopNT-out 9.6491 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.27, -33.28 APE9-dihe-out -70.41, -15.65 APE8-dihe-out -94.12, 2.48 APE8-rot-na 295.49 APE67-dihe-out -103.53, 27.01 -62.67, 134.47 APE12-dist-na 9.9283 APE11-dist-na 11.4908 APE10-dist-na 16.0829 APE9-dist-out 12.7056 W659A,W777A,F794H None None XRAY 1.939 0.202 0.236 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6oav Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6OBBA O60674 537 808 1132.0 M3Y:901 Type1 Pseudo DFGin 7.3423 13.2339 None -84.34, 177.39 -74.24, 159.35 -79.81, -16.97 27.48, 144.61 78.13, -168.92 out-na out 10.1344 Saltbr-na 999.0 HRD-in -82.45, -60.11 93.59, -13.21 na-out-out SNCaoo out-out ActLoopNT-out 9.7343 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -38.37 APE9-dihe-out -67.29, -18.2 APE8-dihe-out -91.42, 5.55 APE8-rot-na 289.4 APE67-dihe-out -101.89, 28.31 -66.13, 136.22 APE12-dist-na 9.9763 APE11-dist-na 11.4381 APE10-dist-na 16.1001 APE9-dist-out 12.826 W659A,W777A,F794H None None XRAY 1.904 0.197 0.225 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obb Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6OBFA O60674 537 808 1132.0 M4G:902 Type1 Pseudo DFGin 5.8016 13.5747 None -75.4, 175.18 -69.61, 155.48 -61.14, -31.23 333.27, 38.74 78.42, -174.91 out-na out 11.7301 Saltbr-na 999.0 HRD-in -79.03, -58.03 90.73, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.1257 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.35, -37.95 APE9-dihe-out -66.08, -20.0 APE8-dihe-out -89.74, 3.4 APE8-rot-na 287.78 APE67-dihe-out -103.65, 28.29 -65.52, 135.12 APE12-dist-na 9.8761 APE11-dist-na 11.4144 APE10-dist-na 16.0183 APE9-dist-out 12.5198 W659A,W777A,F794H None None XRAY 1.71 0.199 0.222 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obf Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6OBLA O60674 537 808 1132.0 M4P:901 Type1 Pseudo DFGin 6.1314 13.618 None -84.06, 175.88 -72.71, 160.31 -68.63, -25.11 336.97, 36.63 73.61, -166.98 out-na out 11.5997 Saltbr-na 999.0 HRD-in -78.47, -60.55 94.84, -3.9 na-out-out SNCaoo out-out ActLoopNT-out 9.0751 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.59, -34.77 APE9-dihe-out -65.45, -25.46 APE8-dihe-out -86.12, 6.91 APE8-rot-na 289.77 APE67-dihe-out -101.28, 22.22 -64.94, 134.76 APE12-dist-na 9.8653 APE11-dist-na 11.3953 APE10-dist-na 16.0439 APE9-dist-out 12.7108 W659A,W777A,F794H None None XRAY 2.061 0.2 0.239 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6obl Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6OCCA O60674 537 808 1132.0 M57:1002 Type1 Pseudo DFGin 6.0618 13.5692 None -84.33, 174.58 -71.42, 156.44 -66.05, -27.79 338.24, 34.72 78.91, -171.69 out-na out 11.7166 Saltbr-na 999.0 HRD-in -79.87, -63.55 97.41, -5.73 na-out-out SNCaoo out-out ActLoopNT-out 9.2604 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.17, -40.0 APE9-dihe-out -66.58, -22.02 APE8-dihe-out -86.2, 2.55 APE8-rot-na 295.02 APE67-dihe-out -102.04, 27.42 -65.31, 136.06 APE12-dist-na 9.937 APE11-dist-na 11.4119 APE10-dist-na 16.0003 APE9-dist-out 12.4336 W659A,W777A,F794H None None XRAY 2.03 0.227 0.272 A 289.0 268.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6occ Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 6XJKA O60674 539 807 1132.0 V4D:901 Type1 Pseudo DFGin 7.0861 13.1101 None -82.39, -178.8 -73.6, 159.61 -82.47, -18.87 26.68, 148.75 79.98, -172.67 out-na out 10.9429 Saltbr-na 999.0 HRD-in -78.39, -61.79 94.59, -5.62 na-out-out SNCaoo out-out ActLoopNT-out 9.1768 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.63, -38.8 APE9-dihe-out -69.88, -19.28 APE8-dihe-out -90.06, 4.72 APE8-rot-na 291.97 APE67-dihe-out -100.24, 24.73 -62.96, 137.34 APE12-dist-na 9.833 APE11-dist-na 11.6512 APE10-dist-na 16.1346 APE9-dist-out 12.5371 W659A,W777A,F794H None None XRAY 2.024 0.229 0.273 A 289.0 265.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 6xjk Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 7JYOA O60674 539 808 1132.0 VPS:901 Type1 Pseudo DFGin 7.3133 13.2651 None -88.9, -179.5 -76.4, 155.67 -78.17, -11.76 25.61, 146.28 75.85, -168.38 in-na in 9.9397 Saltbr-na 999.0 HRD-in -78.1, -62.53 100.04, -11.32 na-out-out SNCaoo out-out ActLoopNT-out 9.47 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.05, -35.44 APE9-dihe-out -67.28, -21.98 APE8-dihe-out -89.32, 5.73 APE8-rot-na 292.48 APE67-dihe-out -104.2, 24.04 -63.78, 134.25 APE12-dist-na 10.0063 APE11-dist-na 11.4947 APE10-dist-na 16.0721 APE9-dist-out 12.6709 W659A,W777A,F794H None None XRAY 2.161 0.188 0.246 A 289.0 270.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7jyo Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 7JYQA O60674 537 808 1132.0 VPJ:902 Type1 Pseudo DFGin 7.645 13.0055 None -92.98, -175.16 -77.54, 154.64 -78.8, -12.58 29.28, 143.4 74.39, -171.67 out-na out 13.0732 Saltbr-na 999.0 HRD-in -86.04, -59.14 96.24, -12.09 na-out-out SNCaoo out-out ActLoopNT-out 9.8115 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.31, -38.61 APE9-dihe-out -62.73, -23.3 APE8-dihe-out -89.27, 2.43 APE8-rot-na 292.66 APE67-dihe-out -102.33, 26.3 -62.62, 135.22 APE12-dist-na 10.0152 APE11-dist-na 11.5681 APE10-dist-na 16.1683 APE9-dist-out 12.8664 W659A,W777A,F794H None None XRAY 1.859 0.181 0.221 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7jyq Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 7SZWA O60674 537 808 1132.0 DVY:901 Type1 Pseudo DFGin 6.4516 13.2599 None -82.57, 177.58 -73.21, 157.07 -69.74, -29.09 341.81, 33.15 77.93, -172.46 out-na out 12.3056 Saltbr-na 999.0 HRD-in -80.57, -59.83 95.34, -11.68 na-out-out SNCaoo out-out ActLoopNT-out 9.2552 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -37.85 APE9-dihe-out -63.74, -25.15 APE8-dihe-out -91.51, 8.03 APE8-rot-na 297.58 APE67-dihe-out -99.24, 24.79 -65.54, 137.42 APE12-dist-na 9.9259 APE11-dist-na 11.4265 APE10-dist-na 16.0645 APE9-dist-out 12.4083 W659A,W777A,F794H None None XRAY 1.906 0.195 0.226 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7szw Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 7T0PA O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.5356 13.4525 None -71.36, 169.62 -64.37, 154.19 -64.4, -34.91 335.03, 35.41 82.73, -164.25 out-na out 11.6251 Saltbr-na 999.0 HRD-in -78.49, -60.16 92.47, -7.36 na-out-out SNCaoo out-out ActLoopNT-out 9.4113 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.7, -41.68 APE9-dihe-out -61.62, -27.73 APE8-dihe-out -89.13, 13.42 APE8-rot-na 292.46 APE67-dihe-out -104.69, 27.09 -67.15, 136.9 APE12-dist-na 10.1283 APE11-dist-na 11.4772 APE10-dist-na 16.1721 APE9-dist-out 12.8246 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t0p Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 7T0PB O60674 536 808 1132.0 E3W:901 Type1 Pseudo DFGin 5.5841 13.3753 None -73.4, 171.14 -67.99, 156.9 -65.04, -35.98 333.3, 36.74 84.58, -160.86 out-na out 11.6751 Saltbr-na 999.0 HRD-in -82.44, -59.87 91.7, -5.68 na-out-out SNCaoo out-out ActLoopNT-out 9.5252 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.77, -34.38 APE9-dihe-out -70.23, -20.91 APE8-dihe-out -95.01, 13.79 APE8-rot-na 294.77 APE67-dihe-out -106.03, 28.99 -67.37, 133.92 APE12-dist-na 10.0828 APE11-dist-na 11.624 APE10-dist-na 16.2602 APE9-dist-out 12.9567 W659A,W777A,F794H None None XRAY 2.04 0.197 0.247 B 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t0p Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 7T1TA O60674 536 809 1132.0 E8I:901 Type1 Pseudo DFGin 7.0745 13.1989 None -85.56, -179.34 -72.27, 154.59 -78.75, -8.81 22.02, 154.16 65.96, -165.49 out-na out 10.8121 Saltbr-na 999.0 HRD-in -83.69, -59.16 91.95, -7.4 na-out-out SNCaoo out-out ActLoopNT-out 9.7297 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.83, -40.65 APE9-dihe-out -65.84, -24.48 APE8-dihe-out -87.52, 8.41 APE8-rot-na 292.81 APE67-dihe-out -105.4, 28.45 -65.24, 133.84 APE12-dist-na 9.9478 APE11-dist-na 11.6118 APE10-dist-na 16.1823 APE9-dist-out 12.9375 W659A,W777A,F794H None None XRAY 2.08 0.183 0.228 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 7t1t Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8B9HA O60674 536 809 1132.0 Q7F:901 Type1 Pseudo DFGin 6.0102 13.3074 None -84.93, -177.89 -74.12, 157.3 -67.76, -31.57 343.4, 32.07 81.26, -168.8 out-na out 12.0967 Saltbr-na 999.0 HRD-in -82.25, -60.3 91.76, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 9.1429 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.85, -39.85 APE9-dihe-out -62.27, -26.85 APE8-dihe-out -86.04, 1.76 APE8-rot-na 292.25 APE67-dihe-out -100.68, 23.58 -62.84, 136.16 APE12-dist-na 9.712 APE11-dist-na 11.4338 APE10-dist-na 15.9334 APE9-dist-out 12.4277 W659A,W777A,F794H None None XRAY 1.5 0.182 0.208 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9h Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8BA3A O60674 536 812 1132.0 Q8U:60901 Type1 Pseudo DFGin 7.9449 13.7079 None -77.62, 172.89 -67.28, 156.81 -77.15, -9.78 24.71, 146.25 70.37, -168.01 out-na out 10.5812 Saltbr-na 999.0 HRD-in -73.02, -63.41 91.28, -5.41 na-out-out SNCaoo out-out ActLoopNT-out 8.8315 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.97, -37.88 APE9-dihe-out -69.87, -18.94 APE8-dihe-out -88.79, 5.92 APE8-rot-na 290.58 APE67-dihe-out -110.89, 28.54 -69.8, 129.69 APE12-dist-na 10.0415 APE11-dist-na 11.8896 APE10-dist-na 16.4253 APE9-dist-out 12.5092 W659A,W777A,F794H None None XRAY 1.4 0.175 0.197 A 289.0 277.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ba3 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8EX0A O60674 536 808 1132.0 AQG:901 Type1 Pseudo DFGin 7.4123 13.4018 None -87.55, 174.91 -71.81, 159.18 -77.63, -11.45 24.29, 145.18 73.87, -172.91 in-na in 9.643 Saltbr-na 999.0 HRD-in -81.87, -61.41 94.19, -7.67 na-out-out SNCaoo out-out ActLoopNT-out 9.6084 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.42, -37.24 APE9-dihe-out -64.33, -22.0 APE8-dihe-out -89.33, 0.5 APE8-rot-na 287.44 APE67-dihe-out -103.06, 26.06 -59.07, 135.76 APE12-dist-na 9.8884 APE11-dist-na 11.5611 APE10-dist-na 16.1357 APE9-dist-out 12.686 W659A,W777A,F794H None None XRAY 1.85 0.179 0.228 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex0 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8EX1A O60674 537 808 1132.0 AD5:901 Type1 Pseudo DFGin 7.2822 13.5699 None -94.73, 174.88 -71.85, 156.73 -78.3, -7.64 23.96, 145.89 75.85, -176.26 in-na in 9.8513 Saltbr-na 999.0 HRD-in -83.17, -61.66 95.43, -4.68 na-out-out SNCaoo out-out ActLoopNT-out 9.7446 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.78, -38.61 APE9-dihe-out -63.17, -26.48 APE8-dihe-out -86.79, 6.17 APE8-rot-na 291.87 APE67-dihe-out -106.59, 26.74 -65.58, 134.04 APE12-dist-na 9.8512 APE11-dist-na 11.5504 APE10-dist-na 16.0568 APE9-dist-out 12.7733 W659A,W777A,F794H None None XRAY 1.5 0.169 0.191 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex1 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 8EX2A O60674 536 808 1132.0 Q2Q:901 Type1 Pseudo DFGin 7.6828 13.3897 None -89.91, 173.83 -74.44, 158.35 -75.25, -10.25 27.64, 142.49 74.64, -169.3 in-na in 9.7258 Saltbr-na 999.0 HRD-in -84.46, -65.65 96.23, -6.71 na-out-out SNCaoo out-out ActLoopNT-out 9.5614 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.11, -41.46 APE9-dihe-out -59.07, -26.71 APE8-dihe-out -87.22, 3.02 APE8-rot-na 287.18 APE67-dihe-out -104.5, 26.8 -63.95, 134.55 APE12-dist-na 9.9758 APE11-dist-na 11.51 APE10-dist-na 16.1308 APE9-dist-out 12.6339 W659A,W777A,F794H None None XRAY 1.9 0.172 0.203 A 289.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8ex2 Homo sapiens TYR_JAK2-1_HUMAN TYR 2.7e-64 222.9 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 9ND5A O60674 536 809 1132.0 A1BXA:901 Type1 Pseudo DFGin 7.1967 13.4361 None -78.37, 174.28 -71.06, 155.85 -82.01, -13.03 28.16, 149.91 71.45, -157.96 out-na out 10.3765 Saltbr-na 999.0 HRD-in -81.65, -70.18 103.7, -2.47 na-out-out SNCaoo out-out ActLoopNT-out 9.4735 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -76.62, -29.08 APE9-dihe-out -76.41, -20.7 APE8-dihe-out -84.83, 10.94 APE8-rot-na 287.64 APE67-dihe-out -108.27, 36.81 -81.67, 130.11 APE12-dist-na 9.6535 APE11-dist-na 11.4413 APE10-dist-na 16.0178 APE9-dist-out 12.4531 None None None XRAY 2.4 0.214 0.278 A 280.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 9nd5 Homo sapiens TYR_JAK2-1_HUMAN TYR 2.8e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
JAK2-1 JAK2_HUMAN 9ND3A O60674 536 808 1132.0 A1BW6:901 Type1 Pseudo DFGin 5.9957 13.1158 None -64.1, 173.67 -70.95, 163.72 -78.01, -24.74 341.83, 32.74 77.82, -165.18 out-na out 11.374 Saltbr-na 999.0 HRD-in -84.19, -60.63 89.29, -1.33 na-out-out SNCaoo out-out ActLoopNT-out 9.1954 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.37, -39.11 APE9-dihe-out -58.8, -29.7 APE8-dihe-out -87.32, 4.81 APE8-rot-na 289.91 APE67-dihe-out -104.68, 28.28 -65.86, 133.14 APE12-dist-na 9.6569 APE11-dist-na 11.4611 APE10-dist-na 16.0024 APE9-dist-out 12.276 None None None XRAY 1.62 0.189 0.22 A 283.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 9nd3 Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2

TYR_JAK2-1 (Tyrosine-protein kinase JAK2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name