OTHER_EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3)

Total number of chains: 15
Active chains: 2
Uniprot: E2AK3_HUMAN
Kinase Domain Residues: 593 - 1077
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 8 53.3% 7MF0AAA
DFGout BBAminus 4 26.7% 4X7KA
DFGin BLAminus 2 13.3% AF-Q9NZJ5-K1A
DFGout None 1 6.7% 4X7HA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q9NZJ5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 585 - 1085 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3
AF-Q9NZJ5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 585 - 1085 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3
4X7OA 2.65 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 3Z6 Type1 585 - 1081 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
7MF0AAA 2.809 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn Z6P Type1 586 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
8EQ9AAA 2.86 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn WPB Type1 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
8EQDAAA 2.92 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn WPX Type1 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
4G31A 2.28 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 0WH Type1.5_Back 588 - 1080 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3
4G34A 2.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 924 Type1.5_Back 588 - 1079 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3
4M7IA 2.34 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 27D Type1.5_Back 588 - 1080 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3
8EQEAAA 2.559 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn WQ2 Type1.5_Back 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
4X7JA 2.3 Inactive DFGout‑BBAminus out-out none-none nonTYR APEdihe_aannn APEdist_nnnn 3Z1 Type1 585 - 1086 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
4X7KA 1.8 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 3Z3 Type2 585 - 1087 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
4X7LA 1.9 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 3Z4 Type2 585 - 1087 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
4X7NA 2.35 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 3Z5 Type2 585 - 1087 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
4X7HA 2.0 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn 3Z2 Type2 585 - 1086 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3

OTHER_EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3)

Total number of chains: 16
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 9 56.2% 7MF0AAA
DFGout BBAminus 4 25.0% 4X7KA
DFGin BLAminus 2 12.5% AF-Q9NZJ5-K1A
DFGout None 1 6.2% 4X7HA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
E2AK3_HUMAN AF-Q9NZJ5-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 585 - 1085 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN AF-Q9NZJ5-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 585 - 1085 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 4X7OA 2.65 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 3Z6 Type1 585 - 1081 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 7MF0AAA 2.809 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn Z6P Type1 586 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 8EQ9AAA 2.86 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn WPB Type1 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 8EQDAAA 2.92 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn WPX Type1 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 4G31A 2.28 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 0WH Type1.5_Back 588 - 1080 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 4G34A 2.7 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 924 Type1.5_Back 588 - 1079 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 4M7IA 2.34 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 27D Type1.5_Back 588 - 1080 0 None None Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 8EQEAAA 2.559 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn WQ2 Type1.5_Back 585 - 1080 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 4X7JA 2.3 Inactive DFGout‑BBAminus out-out none-none nonTYR APEdihe_aannn APEdist_nnnn 3Z1 Type1 585 - 1086 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 4X7KA 1.8 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 3Z3 Type2 585 - 1087 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 4X7LA 1.9 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 3Z4 Type2 585 - 1087 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 4X7NA 2.35 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn 3Z5 Type2 585 - 1087 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_HUMAN 4X7HA 2.0 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn 3Z2 Type2 585 - 1086 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
E2AK3_MOUSE 3QD2B 2.81 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aanoo APEdist_iiin No_ligand No_ligand 582 - 1078 0 TPO980 None Eukaryotic translation initiation factor 2-alpha kinase 3 Mus musculus

OTHER_EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3)

Total number of chains: 1
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 1 100.0% 3QD2B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
E2AK3_MOUSE 3QD2B 2.81 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aanoo APEdist_iiin No_ligand No_ligand 582 - 1078 0 TPO980 None Eukaryotic translation initiation factor 2-alpha kinase 3 Mus musculus