OTHER_EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3)

Total number of chains: 15
Active chains: 2
Uniprot: E2AK3_HUMAN
Kinase Domain Residues: 593 - 1077
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 8 53.3% 7MF0AAA
DFGout BBAminus 4 26.7% 4X7KA
DFGin BLAminus 2 13.3% AF-Q9NZJ5-K1A
DFGout None 1 6.7% 4X7HA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EIF2AK3 AF-Q9NZJ5-K1A Q9NZJ5 585 1085 1116.0 No_ligand No_ligand Active DFGin 6.8694 13.8579 BLAminus -144.99, -173.94 54.37, 67.55 -75.34, 20.54 292.33, 90.53 -60.73, -19.34 in-in in 9.1317 Saltbr-in 2.7032 HRD-in -81.34, -41.96 64.36, -15.0 in-in-in SNCiii in-in ActLoopNT-in 2.9906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.8, 151.1 APE9-dihe-na 99.93, 176.91 APE8-dihe-in -81.29, 119.6 APE8-rot-in 301.9 APE67-dihe-in -78.31, -22.78 -45.12, -27.42 APE12-dist-in 11.0984 APE11-dist-in 12.4051 APE10-dist-in 6.4452 APE9-dist-in 3.6772 None None None AF2 -1.0 1.0 1.0 A 501.0 501.0 0 40 40 0 [[593, 1077]] 1.0 AF-Q9NZJ5-K1 OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 AF-Q9NZJ5-K3A Q9NZJ5 585 1085 1116.0 No_ligand No_ligand Active DFGin 6.6081 13.7326 BLAminus -140.91, -171.67 54.11, 63.74 -75.27, 21.29 296.22, 91.12 -60.87, -20.0 in-in in 8.242 Saltbr-in 2.6715 HRD-in -80.93, -43.84 66.73, -9.25 in-in-in SNCiii in-in ActLoopNT-in 2.9395 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.59, 135.8 APE9-dihe-na 120.91, -171.05 APE8-dihe-in -91.04, 118.7 APE8-rot-in 298.86 APE67-dihe-in -66.86, -27.92 -47.06, -34.99 APE12-dist-in 11.2778 APE11-dist-in 12.3757 APE10-dist-in 6.4781 APE9-dist-in 3.4882 None None None AF2 -1.0 1.0 1.0 A 501.0 501.0 0 40 40 0 [[593, 1077]] 1.0 AF-Q9NZJ5-K3 OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 4X7OA Q9NZJ5 585 1081 1116.0 3Z6:1101 Type1 Inactive DFGin 6.3414 13.6426 None -94.22, -155.12 -53.25, 136.69 -155.12, 166.24 66.84, 102.95 73.29, 999.0 out-out out 12.5237 Saltbr-out 8.5689 HRD-in -83.31, -58.9 75.59, 7.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.73 APE8-rot-out 177.5 APE67-dihe-in -54.31, -34.32 -114.42, 10.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.65 0.2 0.226 A 317.0 246.0 46 40 11 29 [[593, 1077]] 1.0 4x7o OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 7MF0AAA Q9NZJ5 586 1080 1116.0 Z6P:61101 Type1 Inactive DFGin 6.0948 13.7835 None -77.51, -156.87 -60.47, 147.45 -172.68, 155.23 76.53, 99.05 77.56, 168.51 out-out out 12.7278 Saltbr-out 8.739 HRD-in -96.15, -47.28 50.09, 33.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.24 APE8-rot-out 176.88 APE67-dihe-in -78.52, -21.92 -131.22, 23.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.809 0.234 0.273 AAA 317.0 259.0 31 40 13 27 [[593, 1077]] 1.0 7mf0 OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 8EQ9AAA Q9NZJ5 585 1080 1116.0 WPB:1101 Type1 Inactive DFGin 6.336 13.3424 None -89.55, -152.51 -63.21, 140.56 -148.5, 177.54 60.71, 99.01 64.9, 170.78 out-out out 12.6992 Saltbr-out 8.372 HRD-in -76.32, -70.44 74.66, 17.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 156.68 APE8-rot-out 169.43 APE67-dihe-in -67.45, -23.48 -135.96, 8.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.86 0.241 0.277 AAA 317.0 253.0 38 40 13 27 [[593, 1077]] 1.0 8eq9 OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 8EQDAAA Q9NZJ5 585 1080 1116.0 WPX:1101 Type1 Inactive DFGin 6.5107 13.3932 None -76.6, -162.05 -50.39, 140.83 -163.18, 172.47 74.08, 87.8 62.7, 177.79 out-out out 12.9537 Saltbr-out 8.0923 HRD-in -67.23, -62.02 65.5, 23.69 out-out-out SNCooo out-out ActLoopNT-out 11.8159 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.26 APE8-rot-out 186.47 APE67-dihe-in -80.59, -35.16 -113.72, 25.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.92 0.248 0.28 AAA 317.0 256.0 35 40 15 25 [[593, 1077]] 1.0 8eqd OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 4G31A Q9NZJ5 588 1080 1116.0 0WH:61102 Type1.5_Back Inactive DFGin 6.2319 13.8316 None -84.54, -159.02 -56.0, 133.56 -155.02, 170.5 66.17, 105.5 78.35, 175.83 out-out out 13.0614 Saltbr-out 9.6996 HRD-in -87.72, -55.13 80.73, -18.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.1 APE8-dihe-in -65.54, 146.89 APE8-rot-out 180.58 APE67-dihe-in -54.55, -32.6 -106.33, 6.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3041 None None None XRAY 2.28 0.205 0.242 A 299.0 247.0 38 40 14 26 [[593, 1077]] 1.0 4g31 OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 4G34A Q9NZJ5 588 1079 1116.0 924:61101 Type1.5_Back Inactive DFGin 6.097 13.6797 None -82.87, -161.08 -56.81, 138.38 -162.6, 172.39 72.3, 101.28 108.73, -50.4 out-out out 12.6916 Saltbr-out 9.7672 HRD-in -88.56, -52.58 79.71, -18.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.81 APE8-dihe-in -70.71, 157.12 APE8-rot-out 46.57 APE67-dihe-in -60.9, -30.41 -107.3, 13.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.2436 None None None XRAY 2.7 0.21 0.258 A 299.0 247.0 37 40 13 27 [[593, 1077]] 1.0 4g34 OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 4M7IA Q9NZJ5 588 1080 1116.0 27D:61101 Type1.5_Back Inactive DFGin 6.0292 13.826 None -84.66, -156.85 -61.94, 137.1 -158.49, 171.52 68.59, 102.9 119.66, -36.59 out-out out 12.7894 Saltbr-out 10.7583 HRD-in -87.5, -55.06 77.0, -17.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.52 APE8-dihe-in -64.41, 144.81 APE8-rot-out 183.67 APE67-dihe-in -62.47, -30.87 -109.76, 13.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1349 None None None XRAY 2.34 0.209 0.282 A 299.0 246.0 39 40 14 26 [[593, 1077]] 1.0 4m7i OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 8EQEAAA Q9NZJ5 585 1080 1116.0 WQ2:1101 Type1.5_Back Inactive DFGin 6.2009 13.869 None -81.55, -152.92 -57.14, 146.2 -169.63, 166.16 75.82, 96.97 68.96, 171.99 out-out out 13.2313 Saltbr-out 9.1534 HRD-in -75.93, -57.84 73.17, 14.99 out-out-out SNCooo out-out ActLoopNT-out 12.8182 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.43 APE8-rot-out 173.87 APE67-dihe-in -71.31, -21.9 -114.54, 9.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.559 0.227 0.287 AAA 317.0 256.0 35 40 14 26 [[593, 1077]] 1.0 8eqe OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 4X7JA Q9NZJ5 585 1086 1116.0 3Z1:1101 Type1 Inactive DFGout 12.6457 11.7457 BBAminus -176.98, -166.74 -114.82, 83.88 -76.24, -41.23 290.33, 81.74 65.53, 38.29 out-out out 11.6173 Saltbr-out 8.2516 HRD-in -69.35, -52.51 78.62, -22.7 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.01, -22.0 999.0, 154.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.3 0.196 0.225 A 317.0 257.0 40 40 12 28 [[593, 1077]] 1.0 4x7j OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 4X7KA Q9NZJ5 585 1087 1116.0 3Z3:1101 Type2 Inactive DFGout 12.5439 11.3653 BBAminus -164.33, -167.96 -113.88, 89.92 -77.28, -42.74 283.96, 78.23 66.26, 40.59 out-out out 11.5109 Saltbr-out 9.7057 HRD-in -84.11, -56.75 85.81, -21.5 out-out-out SNCooo out-out ActLoopNT-out 21.1534 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.05 APE8-rot-out 179.62 APE67-dihe-in -59.37, -28.86 -109.52, 8.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 1.8 0.177 0.196 A 317.0 260.0 38 40 14 26 [[593, 1077]] 1.0 4x7k OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 4X7LA Q9NZJ5 585 1087 1116.0 3Z4:1101 Type2 Inactive DFGout 12.642 11.31 BBAminus -164.8, -167.28 -114.04, 88.17 -74.87, -43.18 282.08, 78.75 64.58, 42.25 out-out out 11.456 Saltbr-out 9.8439 HRD-in -84.66, -55.97 85.16, -23.49 out-out-out SNCooo out-out ActLoopNT-out 20.9175 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.96 APE8-rot-out 184.8 APE67-dihe-in -58.09, -32.47 -109.67, 8.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 1.9 0.172 0.193 A 317.0 260.0 38 40 14 26 [[593, 1077]] 1.0 4x7l OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 4X7NA Q9NZJ5 585 1087 1116.0 3Z5:1101 Type2 Inactive DFGout 12.6245 11.3362 BBAminus -159.96, -166.6 -113.91, 86.84 -73.68, -38.78 284.48, 77.45 62.04, 46.12 out-out out 11.4657 Saltbr-out 9.7703 HRD-in -89.68, -53.93 84.75, -24.71 out-out-out SNCooo out-out ActLoopNT-out 21.1027 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.8 APE8-rot-out 184.51 APE67-dihe-in -64.57, -30.33 -109.92, 11.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.35 0.211 0.245 A 317.0 259.0 39 40 14 26 [[593, 1077]] 1.0 4x7n OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 4X7HA Q9NZJ5 585 1086 1116.0 3Z2:1101 Type2 Inactive DFGout 16.9881 7.9877 None -147.44, -164.97 -147.31, 104.14 -56.25, -41.74 188.75, 74.74 -79.36, 999.0 out-out out 11.6917 Saltbr-out 7.3605 HRD-in -84.56, -56.41 85.91, -24.54 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.13 APE8-rot-in 311.97 APE67-dihe-in -61.01, -23.09 -108.5, -0.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.0 0.202 0.214 A 317.0 256.0 41 40 11 29 [[593, 1077]] 1.0 4x7h OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3

OTHER_EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3)

Total number of chains: 16
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 9 56.2% 7MF0AAA
DFGout BBAminus 4 25.0% 4X7KA
DFGin BLAminus 2 12.5% AF-Q9NZJ5-K1A
DFGout None 1 6.2% 4X7HA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EIF2AK3 E2AK3_HUMAN AF-Q9NZJ5-K1A Q9NZJ5 585 1085 1116.0 No_ligand No_ligand Active DFGin 6.8694 13.8579 BLAminus -144.99, -173.94 54.37, 67.55 -75.34, 20.54 292.33, 90.53 -60.73, -19.34 in-in in 9.1317 Saltbr-in 2.7032 HRD-in -81.34, -41.96 64.36, -15.0 in-in-in SNCiii in-in ActLoopNT-in 2.9906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.8, 151.1 APE9-dihe-na 99.93, 176.91 APE8-dihe-in -81.29, 119.6 APE8-rot-in 301.9 APE67-dihe-in -78.31, -22.78 -45.12, -27.42 APE12-dist-in 11.0984 APE11-dist-in 12.4051 APE10-dist-in 6.4452 APE9-dist-in 3.6772 None None None AF2 -1.0 1.0 1.0 A 501.0 501.0 0 40 40 0 [[593, 1077]] 1.0 AF-Q9NZJ5-K1 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN AF-Q9NZJ5-K3A Q9NZJ5 585 1085 1116.0 No_ligand No_ligand Active DFGin 6.6081 13.7326 BLAminus -140.91, -171.67 54.11, 63.74 -75.27, 21.29 296.22, 91.12 -60.87, -20.0 in-in in 8.242 Saltbr-in 2.6715 HRD-in -80.93, -43.84 66.73, -9.25 in-in-in SNCiii in-in ActLoopNT-in 2.9395 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.59, 135.8 APE9-dihe-na 120.91, -171.05 APE8-dihe-in -91.04, 118.7 APE8-rot-in 298.86 APE67-dihe-in -66.86, -27.92 -47.06, -34.99 APE12-dist-in 11.2778 APE11-dist-in 12.3757 APE10-dist-in 6.4781 APE9-dist-in 3.4882 None None None AF2 -1.0 1.0 1.0 A 501.0 501.0 0 40 40 0 [[593, 1077]] 1.0 AF-Q9NZJ5-K3 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 4X7OA Q9NZJ5 585 1081 1116.0 3Z6:1101 Type1 Inactive DFGin 6.3414 13.6426 None -94.22, -155.12 -53.25, 136.69 -155.12, 166.24 66.84, 102.95 73.29, 999.0 out-out out 12.5237 Saltbr-out 8.5689 HRD-in -83.31, -58.9 75.59, 7.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.73 APE8-rot-out 177.5 APE67-dihe-in -54.31, -34.32 -114.42, 10.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.65 0.2 0.226 A 317.0 246.0 46 40 11 29 [[593, 1077]] 1.0 4x7o Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 7MF0AAA Q9NZJ5 586 1080 1116.0 Z6P:61101 Type1 Inactive DFGin 6.0948 13.7835 None -77.51, -156.87 -60.47, 147.45 -172.68, 155.23 76.53, 99.05 77.56, 168.51 out-out out 12.7278 Saltbr-out 8.739 HRD-in -96.15, -47.28 50.09, 33.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.24 APE8-rot-out 176.88 APE67-dihe-in -78.52, -21.92 -131.22, 23.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.809 0.234 0.273 AAA 317.0 259.0 31 40 13 27 [[593, 1077]] 1.0 7mf0 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 8EQ9AAA Q9NZJ5 585 1080 1116.0 WPB:1101 Type1 Inactive DFGin 6.336 13.3424 None -89.55, -152.51 -63.21, 140.56 -148.5, 177.54 60.71, 99.01 64.9, 170.78 out-out out 12.6992 Saltbr-out 8.372 HRD-in -76.32, -70.44 74.66, 17.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 156.68 APE8-rot-out 169.43 APE67-dihe-in -67.45, -23.48 -135.96, 8.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.86 0.241 0.277 AAA 317.0 253.0 38 40 13 27 [[593, 1077]] 1.0 8eq9 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 8EQDAAA Q9NZJ5 585 1080 1116.0 WPX:1101 Type1 Inactive DFGin 6.5107 13.3932 None -76.6, -162.05 -50.39, 140.83 -163.18, 172.47 74.08, 87.8 62.7, 177.79 out-out out 12.9537 Saltbr-out 8.0923 HRD-in -67.23, -62.02 65.5, 23.69 out-out-out SNCooo out-out ActLoopNT-out 11.8159 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.26 APE8-rot-out 186.47 APE67-dihe-in -80.59, -35.16 -113.72, 25.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.92 0.248 0.28 AAA 317.0 256.0 35 40 15 25 [[593, 1077]] 1.0 8eqd Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 4G31A Q9NZJ5 588 1080 1116.0 0WH:61102 Type1.5_Back Inactive DFGin 6.2319 13.8316 None -84.54, -159.02 -56.0, 133.56 -155.02, 170.5 66.17, 105.5 78.35, 175.83 out-out out 13.0614 Saltbr-out 9.6996 HRD-in -87.72, -55.13 80.73, -18.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.1 APE8-dihe-in -65.54, 146.89 APE8-rot-out 180.58 APE67-dihe-in -54.55, -32.6 -106.33, 6.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3041 None None None XRAY 2.28 0.205 0.242 A 299.0 247.0 38 40 14 26 [[593, 1077]] 1.0 4g31 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 4G34A Q9NZJ5 588 1079 1116.0 924:61101 Type1.5_Back Inactive DFGin 6.097 13.6797 None -82.87, -161.08 -56.81, 138.38 -162.6, 172.39 72.3, 101.28 108.73, -50.4 out-out out 12.6916 Saltbr-out 9.7672 HRD-in -88.56, -52.58 79.71, -18.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.81 APE8-dihe-in -70.71, 157.12 APE8-rot-out 46.57 APE67-dihe-in -60.9, -30.41 -107.3, 13.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.2436 None None None XRAY 2.7 0.21 0.258 A 299.0 247.0 37 40 13 27 [[593, 1077]] 1.0 4g34 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 4M7IA Q9NZJ5 588 1080 1116.0 27D:61101 Type1.5_Back Inactive DFGin 6.0292 13.826 None -84.66, -156.85 -61.94, 137.1 -158.49, 171.52 68.59, 102.9 119.66, -36.59 out-out out 12.7894 Saltbr-out 10.7583 HRD-in -87.5, -55.06 77.0, -17.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.52 APE8-dihe-in -64.41, 144.81 APE8-rot-out 183.67 APE67-dihe-in -62.47, -30.87 -109.76, 13.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1349 None None None XRAY 2.34 0.209 0.282 A 299.0 246.0 39 40 14 26 [[593, 1077]] 1.0 4m7i Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 9.9e-50 175.3 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 8EQEAAA Q9NZJ5 585 1080 1116.0 WQ2:1101 Type1.5_Back Inactive DFGin 6.2009 13.869 None -81.55, -152.92 -57.14, 146.2 -169.63, 166.16 75.82, 96.97 68.96, 171.99 out-out out 13.2313 Saltbr-out 9.1534 HRD-in -75.93, -57.84 73.17, 14.99 out-out-out SNCooo out-out ActLoopNT-out 12.8182 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.43 APE8-rot-out 173.87 APE67-dihe-in -71.31, -21.9 -114.54, 9.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.559 0.227 0.287 AAA 317.0 256.0 35 40 14 26 [[593, 1077]] 1.0 8eqe Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 4X7JA Q9NZJ5 585 1086 1116.0 3Z1:1101 Type1 Inactive DFGout 12.6457 11.7457 BBAminus -176.98, -166.74 -114.82, 83.88 -76.24, -41.23 290.33, 81.74 65.53, 38.29 out-out out 11.6173 Saltbr-out 8.2516 HRD-in -69.35, -52.51 78.62, -22.7 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.01, -22.0 999.0, 154.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.3 0.196 0.225 A 317.0 257.0 40 40 12 28 [[593, 1077]] 1.0 4x7j Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 4X7KA Q9NZJ5 585 1087 1116.0 3Z3:1101 Type2 Inactive DFGout 12.5439 11.3653 BBAminus -164.33, -167.96 -113.88, 89.92 -77.28, -42.74 283.96, 78.23 66.26, 40.59 out-out out 11.5109 Saltbr-out 9.7057 HRD-in -84.11, -56.75 85.81, -21.5 out-out-out SNCooo out-out ActLoopNT-out 21.1534 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.05 APE8-rot-out 179.62 APE67-dihe-in -59.37, -28.86 -109.52, 8.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 1.8 0.177 0.196 A 317.0 260.0 38 40 14 26 [[593, 1077]] 1.0 4x7k Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 4X7LA Q9NZJ5 585 1087 1116.0 3Z4:1101 Type2 Inactive DFGout 12.642 11.31 BBAminus -164.8, -167.28 -114.04, 88.17 -74.87, -43.18 282.08, 78.75 64.58, 42.25 out-out out 11.456 Saltbr-out 9.8439 HRD-in -84.66, -55.97 85.16, -23.49 out-out-out SNCooo out-out ActLoopNT-out 20.9175 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.96 APE8-rot-out 184.8 APE67-dihe-in -58.09, -32.47 -109.67, 8.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 1.9 0.172 0.193 A 317.0 260.0 38 40 14 26 [[593, 1077]] 1.0 4x7l Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 4X7NA Q9NZJ5 585 1087 1116.0 3Z5:1101 Type2 Inactive DFGout 12.6245 11.3362 BBAminus -159.96, -166.6 -113.91, 86.84 -73.68, -38.78 284.48, 77.45 62.04, 46.12 out-out out 11.4657 Saltbr-out 9.7703 HRD-in -89.68, -53.93 84.75, -24.71 out-out-out SNCooo out-out ActLoopNT-out 21.1027 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.8 APE8-rot-out 184.51 APE67-dihe-in -64.57, -30.33 -109.92, 11.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.35 0.211 0.245 A 317.0 259.0 39 40 14 26 [[593, 1077]] 1.0 4x7n Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_HUMAN 4X7HA Q9NZJ5 585 1086 1116.0 3Z2:1101 Type2 Inactive DFGout 16.9881 7.9877 None -147.44, -164.97 -147.31, 104.14 -56.25, -41.74 188.75, 74.74 -79.36, 999.0 out-out out 11.6917 Saltbr-out 7.3605 HRD-in -84.56, -56.41 85.91, -24.54 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.13 APE8-rot-in 311.97 APE67-dihe-in -61.01, -23.09 -108.5, -0.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.0 0.202 0.214 A 317.0 256.0 41 40 11 29 [[593, 1077]] 1.0 4x7h Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2.0 254.0 253.0 954 955 956 958 960 622 639 643 934 936 935 937.0 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
EIF2AK3 E2AK3_MOUSE 3QD2B Q9Z2B5 582 1078 1114.0 No_ligand No_ligand Inactive DFGin 6.7724 14.1264 None -150.06, 46.53 -144.12, 85.35 -92.69, 31.02 296.57, 72.54 -64.49, -13.2 in-in in 8.8002 Saltbr-in 3.0494 HRD-in -78.7, -42.73 44.71, 30.97 in-in-out SNCiio in-out ActLoopNT-in 2.6916 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_iiin APE10-dihe-na -139.11, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 13.91 APE8-rot-out 183.4 APE67-dihe-out -53.62, -40.83 54.78, -116.69 APE12-dist-in 11.9859 APE11-dist-in 12.2601 APE10-dist-in 7.0504 APE9-dist-none 999.0 None TPO980 TPO980 XRAY 2.81 0.273 0.332 B 332.0 272.0 60 40 25 15 [[382, 1075]] 1.0 3qd2 Mus musculus OTHER_EIF2AK3_MOUSE OTHER 5e-49 173.1 2.0 254.0 253.0 952 953 954 956 958 618 635 639 932 934 933 935.0 1004 992 987 986 985 984 983 982 981 887 Eukaryotic translation initiation factor 2-alpha kinase 3

OTHER_EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3)

Total number of chains: 1
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 1 100.0% 3QD2B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EIF2AK3 E2AK3_MOUSE 3QD2B Q9Z2B5 582 1078 1114.0 No_ligand No_ligand Inactive DFGin 6.7724 14.1264 None -150.06, 46.53 -144.12, 85.35 -92.69, 31.02 296.57, 72.54 -64.49, -13.2 in-in in 8.8002 Saltbr-in 3.0494 HRD-in -78.7, -42.73 44.71, 30.97 in-in-out SNCiio in-out ActLoopNT-in 2.6916 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_iiin APE10-dihe-na -139.11, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 13.91 APE8-rot-out 183.4 APE67-dihe-out -53.62, -40.83 54.78, -116.69 APE12-dist-in 11.9859 APE11-dist-in 12.2601 APE10-dist-in 7.0504 APE9-dist-none 999.0 None TPO980 TPO980 XRAY 2.81 0.273 0.332 B 332.0 272.0 60 40 25 15 [[382, 1075]] 1.0 3qd2 Mus musculus OTHER_EIF2AK3_MOUSE OTHER 5e-49 173.1 2.0 254.0 253.0 952 953 954 956 958 618 635 639 932 934 933 935.0 1004 992 987 986 985 984 983 982 981 887 Eukaryotic translation initiation factor 2-alpha kinase 3