TYR_ABL2 (Tyrosine-protein kinase ABL2)

Total number of chains: 7
Active chains: 2
Uniprot: ABL2_HUMAN
Kinase Domain Residues: 288 - 541
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 71.4% AF-P42684-K1A
DFGinter None 1 14.3% 3HMIA
DFGout BBAminus 1 14.3% 3GVUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ABL2 AF-P42684-K1A P42684 280 549 1182.0 No_ligand No_ligand Active DFGin 6.7056 13.6827 BLAminus -123.07, -149.56 30.33, 67.97 -82.67, 15.82 300.55, 100.72 -57.81, -38.97 in-in in 7.8957 Saltbr-in 2.6654 HRD-in -81.77, -46.21 69.33, -14.38 in-in-in SNCiii in-in ActLoopNT-in 2.9848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.41, 141.5 APE9-dihe-in -128.87, 154.05 APE8-dihe-in -69.69, 90.07 APE8-rot-na 30.08 APE67-dihe-in -69.45, -19.1 -44.35, -41.47 APE12-dist-na 14.8025 APE11-dist-na 10.0562 APE10-dist-na 12.5067 APE9-dist-in 6.9995 None None None AF2 -1.0 1.0 1.0 A 270.0 270.0 0 29 29 0 [[288, 541]] 1.0 AF-P42684-K1 TYR_ABL2_HUMAN TYR 1.8e-98 334.9 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 AF-P42684-K3A P42684 280 549 1182.0 No_ligand No_ligand Active DFGin 6.4382 13.1215 BLAminus -139.98, -175.48 56.92, 64.58 -77.48, 10.53 304.35, 106.98 -57.67, -34.14 in-in in 7.8739 Saltbr-in 2.6651 HRD-in -89.25, -46.56 66.66, -10.23 in-in-in SNCiii in-in ActLoopNT-in 2.9778 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.01, 136.36 APE9-dihe-in -124.58, 154.89 APE8-dihe-in -73.54, 85.42 APE8-rot-na 33.6 APE67-dihe-in -65.68, -25.11 -39.49, -45.91 APE12-dist-na 14.6645 APE11-dist-na 9.9126 APE10-dist-na 12.1268 APE9-dist-in 6.8156 None None None AF2 -1.0 1.0 1.0 A 270.0 270.0 0 29 29 0 [[288, 541]] 1.0 AF-P42684-K3 TYR_ABL2_HUMAN TYR 1.8e-98 334.9 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 3HMIA P42684 279 546 1182.0 DKI:1 Type1 Inactive DFGinter 9.1638 4.8262 None -59.51, 142.63 -137.26, 25.26 -75.0, 160.51 298.16, 114.52 70.44, 20.34 in-in in 8.257 Saltbr-in 2.503 HRD-in -92.76, -51.88 76.23, -2.59 in-out-in SNCioi out-in ActLoopNT-out 5.7875 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.13, 129.9 APE9-dihe-in -117.54, 160.6 APE8-dihe-in -76.74, 91.54 APE8-rot-na 26.07 APE67-dihe-in -69.21, -5.26 -46.03, -53.32 APE12-dist-na 19.2053 APE11-dist-na 14.3737 APE10-dist-na 16.8455 APE9-dist-in 6.8515 None None None XRAY 1.65 0.19 0.234 A 292.0 268.0 0 29 29 0 [[288, 541]] 1.0 3hmi TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 3GVUA P42684 279 546 1182.0 STI:61001,STI:61002 Type2,Allosteric Inactive DFGout 14.2058 10.9847 BBAminus -129.16, -178.93 -150.61, 104.02 -86.08, -7.91 307.76, 136.33 64.98, 42.87 in-in in 8.1525 Saltbr-in 2.5576 HRD-in -78.06, -56.85 84.44, -8.66 in-out-none SNCion out-none ActLoopNT-out 16.2997 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 108.72 APE9-dihe-in -120.18, 140.1 APE8-dihe-in -84.77, 90.02 APE8-rot-na 31.34 APE67-dihe-in -70.3, -17.18 -52.1, -40.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.1959 APE9-dist-in 7.6056 None None None XRAY 2.05 0.191 0.226 A 292.0 261.0 7 29 22 7 [[288, 541]] 1.0 3gvu TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 2XYNA P42684 280 545 1182.0 VX6:547 Type1 None DFGin 6.7261 13.6649 BLAminus -141.99, -170.21 61.28, 77.47 -101.93, 23.58 303.32, 105.26 -52.42, -36.84 in-none in 8.1058 Saltbr-none 999.0 HRD-in -82.56, -45.09 67.49, 2.25 none-in-in SNCnii in-in ActLoopNT-in 2.8482 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.06, 130.57 APE9-dihe-in -121.58, 155.8 APE8-dihe-in -71.6, 101.71 APE8-rot-na 8.43 APE67-dihe-in -61.12, -28.03 -60.11, -40.42 APE12-dist-na 15.1229 APE11-dist-na 10.4578 APE10-dist-na 12.9615 APE9-dist-in 7.277 None None None XRAY 2.81 0.248 0.284 A 292.0 264.0 2 29 29 0 [[288, 541]] 1.0 2xyn TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 2XYNB P42684 280 545 1182.0 VX6:547,VX6:548,VX6:549 Type1,Allosteric,Allosteric None DFGin 6.7874 14.1937 BLAminus -138.52, -171.96 62.0, 76.57 -98.4, 37.01 307.54, 93.03 -56.63, -28.99 in-none in 7.8076 Saltbr-none 999.0 HRD-in -81.21, -46.34 70.67, 2.12 none-in-in SNCnii in-in ActLoopNT-in 2.9156 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.55, 131.03 APE9-dihe-in -120.39, 161.06 APE8-dihe-in -76.17, 99.71 APE8-rot-na 7.55 APE67-dihe-in -60.42, -29.93 -57.47, -41.84 APE12-dist-na 15.2497 APE11-dist-na 10.5378 APE10-dist-na 13.0049 APE9-dist-in 7.2355 None None None XRAY 2.81 0.248 0.284 B 292.0 264.0 2 29 29 0 [[288, 541]] 1.0 2xyn TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 2XYNC P42684 281 544 1182.0 VX6:547,VX6:548,VX6:549 Type1,Allosteric,Allosteric None DFGin 6.5211 13.6353 BLAminus -141.45, -177.42 57.6, 72.0 -90.09, 30.83 307.64, 101.04 -59.75, -48.16 in-none in 8.5826 Saltbr-none 999.0 HRD-in -84.39, -43.51 69.55, 0.12 none-in-in SNCnii in-in ActLoopNT-in 2.8247 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.88, 131.51 APE9-dihe-in -121.6, 159.94 APE8-dihe-in -76.78, 100.51 APE8-rot-na 6.7 APE67-dihe-in -59.8, -28.69 -55.61, -43.88 APE12-dist-na 14.8175 APE11-dist-na 10.133 APE10-dist-na 12.4878 APE9-dist-in 7.2426 None None None XRAY 2.81 0.248 0.284 C 292.0 262.0 2 29 29 0 [[288, 541]] 1.0 2xyn TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2

TYR_ABL2 (Tyrosine-protein kinase ABL2)

Total number of chains: 9
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 7 77.8% AF-P42684-K1A
DFGinter None 1 11.1% 3HMIA
DFGout BBAminus 1 11.1% 3GVUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ABL2 ABL2_HUMAN AF-P42684-K1A P42684 280 549 1182.0 No_ligand No_ligand Active DFGin 6.7056 13.6827 BLAminus -123.07, -149.56 30.33, 67.97 -82.67, 15.82 300.55, 100.72 -57.81, -38.97 in-in in 7.8957 Saltbr-in 2.6654 HRD-in -81.77, -46.21 69.33, -14.38 in-in-in SNCiii in-in ActLoopNT-in 2.9848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.41, 141.5 APE9-dihe-in -128.87, 154.05 APE8-dihe-in -69.69, 90.07 APE8-rot-na 30.08 APE67-dihe-in -69.45, -19.1 -44.35, -41.47 APE12-dist-na 14.8025 APE11-dist-na 10.0562 APE10-dist-na 12.5067 APE9-dist-in 6.9995 None None None AF2 -1.0 1.0 1.0 A 270.0 270.0 0 29 29 0 [[288, 541]] 1.0 AF-P42684-K1 Homo sapiens TYR_ABL2_HUMAN TYR 1.8e-98 334.9 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 ABL2_HUMAN AF-P42684-K3A P42684 280 549 1182.0 No_ligand No_ligand Active DFGin 6.4382 13.1215 BLAminus -139.98, -175.48 56.92, 64.58 -77.48, 10.53 304.35, 106.98 -57.67, -34.14 in-in in 7.8739 Saltbr-in 2.6651 HRD-in -89.25, -46.56 66.66, -10.23 in-in-in SNCiii in-in ActLoopNT-in 2.9778 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.01, 136.36 APE9-dihe-in -124.58, 154.89 APE8-dihe-in -73.54, 85.42 APE8-rot-na 33.6 APE67-dihe-in -65.68, -25.11 -39.49, -45.91 APE12-dist-na 14.6645 APE11-dist-na 9.9126 APE10-dist-na 12.1268 APE9-dist-in 6.8156 None None None AF2 -1.0 1.0 1.0 A 270.0 270.0 0 29 29 0 [[288, 541]] 1.0 AF-P42684-K3 Homo sapiens TYR_ABL2_HUMAN TYR 1.8e-98 334.9 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 ABL2_HUMAN 3HMIA P42684 279 546 1182.0 DKI:1 Type1 Inactive DFGinter 9.1638 4.8262 None -59.51, 142.63 -137.26, 25.26 -75.0, 160.51 298.16, 114.52 70.44, 20.34 in-in in 8.257 Saltbr-in 2.503 HRD-in -92.76, -51.88 76.23, -2.59 in-out-in SNCioi out-in ActLoopNT-out 5.7875 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.13, 129.9 APE9-dihe-in -117.54, 160.6 APE8-dihe-in -76.74, 91.54 APE8-rot-na 26.07 APE67-dihe-in -69.21, -5.26 -46.03, -53.32 APE12-dist-na 19.2053 APE11-dist-na 14.3737 APE10-dist-na 16.8455 APE9-dist-in 6.8515 None None None XRAY 1.65 0.19 0.234 A 292.0 268.0 0 29 29 0 [[288, 541]] 1.0 3hmi Homo sapiens TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 ABL2_HUMAN 3GVUA P42684 279 546 1182.0 STI:61001,STI:61002 Type2,Allosteric Inactive DFGout 14.2058 10.9847 BBAminus -129.16, -178.93 -150.61, 104.02 -86.08, -7.91 307.76, 136.33 64.98, 42.87 in-in in 8.1525 Saltbr-in 2.5576 HRD-in -78.06, -56.85 84.44, -8.66 in-out-none SNCion out-none ActLoopNT-out 16.2997 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 108.72 APE9-dihe-in -120.18, 140.1 APE8-dihe-in -84.77, 90.02 APE8-rot-na 31.34 APE67-dihe-in -70.3, -17.18 -52.1, -40.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.1959 APE9-dist-in 7.6056 None None None XRAY 2.05 0.191 0.226 A 292.0 261.0 7 29 22 7 [[288, 541]] 1.0 3gvu Homo sapiens TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 ABL2_HUMAN 2XYNA P42684 280 545 1182.0 VX6:547 Type1 None DFGin 6.7261 13.6649 BLAminus -141.99, -170.21 61.28, 77.47 -101.93, 23.58 303.32, 105.26 -52.42, -36.84 in-none in 8.1058 Saltbr-none 999.0 HRD-in -82.56, -45.09 67.49, 2.25 none-in-in SNCnii in-in ActLoopNT-in 2.8482 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.06, 130.57 APE9-dihe-in -121.58, 155.8 APE8-dihe-in -71.6, 101.71 APE8-rot-na 8.43 APE67-dihe-in -61.12, -28.03 -60.11, -40.42 APE12-dist-na 15.1229 APE11-dist-na 10.4578 APE10-dist-na 12.9615 APE9-dist-in 7.277 None None None XRAY 2.81 0.248 0.284 A 292.0 264.0 2 29 29 0 [[288, 541]] 1.0 2xyn Homo sapiens TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 ABL2_HUMAN 2XYNB P42684 280 545 1182.0 VX6:547,VX6:548,VX6:549 Type1,Allosteric,Allosteric None DFGin 6.7874 14.1937 BLAminus -138.52, -171.96 62.0, 76.57 -98.4, 37.01 307.54, 93.03 -56.63, -28.99 in-none in 7.8076 Saltbr-none 999.0 HRD-in -81.21, -46.34 70.67, 2.12 none-in-in SNCnii in-in ActLoopNT-in 2.9156 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.55, 131.03 APE9-dihe-in -120.39, 161.06 APE8-dihe-in -76.17, 99.71 APE8-rot-na 7.55 APE67-dihe-in -60.42, -29.93 -57.47, -41.84 APE12-dist-na 15.2497 APE11-dist-na 10.5378 APE10-dist-na 13.0049 APE9-dist-in 7.2355 None None None XRAY 2.81 0.248 0.284 B 292.0 264.0 2 29 29 0 [[288, 541]] 1.0 2xyn Homo sapiens TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 ABL2_HUMAN 2XYNC P42684 281 544 1182.0 VX6:547,VX6:548,VX6:549 Type1,Allosteric,Allosteric None DFGin 6.5211 13.6353 BLAminus -141.45, -177.42 57.6, 72.0 -90.09, 30.83 307.64, 101.04 -59.75, -48.16 in-none in 8.5826 Saltbr-none 999.0 HRD-in -84.39, -43.51 69.55, 0.12 none-in-in SNCnii in-in ActLoopNT-in 2.8247 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.88, 131.51 APE9-dihe-in -121.6, 159.94 APE8-dihe-in -76.78, 100.51 APE8-rot-na 6.7 APE67-dihe-in -59.8, -28.69 -55.61, -43.88 APE12-dist-na 14.8175 APE11-dist-na 10.133 APE10-dist-na 12.4878 APE9-dist-in 7.2426 None None None XRAY 2.81 0.248 0.284 C 292.0 262.0 2 29 29 0 [[288, 541]] 1.0 2xyn Homo sapiens TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 ABL2_MOUSE 4XLIB Q4JIM5 279 546 1182.0 1N1:600 Type1.5_Back Active DFGin 6.3912 13.6381 BLAminus -131.7, -165.09 47.95, 80.18 -101.55, 32.58 307.48, 89.21 -70.05, -27.33 in-in in 8.2287 Saltbr-in 2.5374 HRD-in -85.97, -54.42 80.41, 14.17 in-in-in SNCiii in-in ActLoopNT-in 3.1 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.09, 129.65 APE9-dihe-in -110.16, 158.75 APE8-dihe-in -72.12, 103.04 APE8-rot-na 29.85 APE67-dihe-in -62.36, -22.19 -57.39, -43.34 APE12-dist-na 15.0495 APE11-dist-na 10.2063 APE10-dist-na 12.5948 APE9-dist-in 7.0962 None None None XRAY 2.5 0.157 0.205 B 268.0 264.0 4 29 29 0 [[288, 541]] 1.0 4xli Mus musculus TYR_ABL2_MOUSE TYR 2e-98 334.8 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 ABL2_MOUSE 4XLIA Q4JIM5 279 546 1182.0 1N1:601 Type1.5_Back Inactive DFGin 6.5075 13.6034 BLAminus -146.93, -165.44 45.19, 75.22 -96.7, 24.95 303.43, 100.32 -77.67, 1.06 in-out in 8.1979 Saltbr-out 4.2161 HRD-in -89.85, -46.08 70.33, 6.25 out-in-in SNCoii in-in ActLoopNT-in 2.9692 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.74, 141.9 APE9-dihe-in -130.79, 158.17 APE8-dihe-in -65.12, 108.35 APE8-rot-na 22.1 APE67-dihe-in -73.67, -11.6 -58.5, -43.4 APE12-dist-na 15.3379 APE11-dist-na 10.7818 APE10-dist-na 13.3164 APE9-dist-in 7.1309 None None None XRAY 2.5 0.157 0.205 A 268.0 264.0 4 29 29 0 [[288, 541]] 1.0 4xli Mus musculus TYR_ABL2_MOUSE TYR 2e-98 334.8 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2

TYR_ABL2 (Tyrosine-protein kinase ABL2)

Total number of chains: 2
Active chains: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4XLIB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ABL2 ABL2_MOUSE 4XLIB Q4JIM5 279 546 1182.0 1N1:600 Type1.5_Back Active DFGin 6.3912 13.6381 BLAminus -131.7, -165.09 47.95, 80.18 -101.55, 32.58 307.48, 89.21 -70.05, -27.33 in-in in 8.2287 Saltbr-in 2.5374 HRD-in -85.97, -54.42 80.41, 14.17 in-in-in SNCiii in-in ActLoopNT-in 3.1 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.09, 129.65 APE9-dihe-in -110.16, 158.75 APE8-dihe-in -72.12, 103.04 APE8-rot-na 29.85 APE67-dihe-in -62.36, -22.19 -57.39, -43.34 APE12-dist-na 15.0495 APE11-dist-na 10.2063 APE10-dist-na 12.5948 APE9-dist-in 7.0962 None None None XRAY 2.5 0.157 0.205 B 268.0 264.0 4 29 29 0 [[288, 541]] 1.0 4xli Mus musculus TYR_ABL2_MOUSE TYR 2e-98 334.8 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
ABL2 ABL2_MOUSE 4XLIA Q4JIM5 279 546 1182.0 1N1:601 Type1.5_Back Inactive DFGin 6.5075 13.6034 BLAminus -146.93, -165.44 45.19, 75.22 -96.7, 24.95 303.43, 100.32 -77.67, 1.06 in-out in 8.1979 Saltbr-out 4.2161 HRD-in -89.85, -46.08 70.33, 6.25 out-in-in SNCoii in-in ActLoopNT-in 2.9692 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.74, 141.9 APE9-dihe-in -130.79, 158.17 APE8-dihe-in -65.12, 108.35 APE8-rot-na 22.1 APE67-dihe-in -73.67, -11.6 -58.5, -43.4 APE12-dist-na 15.3379 APE11-dist-na 10.7818 APE10-dist-na 13.3164 APE9-dist-in 7.1309 None None None XRAY 2.5 0.157 0.205 A 268.0 264.0 4 29 29 0 [[288, 541]] 1.0 4xli Mus musculus TYR_ABL2_MOUSE TYR 2e-98 334.8 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2