PAK4 (Serine/threonine-protein kinase PAK 4)

Group: STE
Uniprot: PAK4_HUMAN
Domain boundary: 321 - 572


Total number of chains: 51
Spatial Dihedral Chains Representative
DFGin BLAminus 49 AF-O96013-K1A
DFGin ABAminus 1 4XBRA
DFGin None 1 4FIGB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
4XBRA 2.94 Inactive DFGin ABAminus in-in in-in ATP Type1 177 - 589 None X474 0
AF-O96013-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 313 - 580 None None 0
2BVAA 2.3 Inactive DFGin BLAminus out-out out-in No_ligand No_ligand 300 - 587 None X474 2
2BVAB 2.3 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 301 - 587 None X474 2
4L67A 2.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 None X474 0
2Q0NA 1.75 Active DFGin BLAminus in-in in-in No_ligand No_ligand 298 - 591 None X474 0
8YHKA 3.3 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 298 - 591 None None 0
2J0IA 1.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 None X474 0
4XBUA 2.06 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 297 - 589 None X474 0
4JDJA 2.3 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 F461V X474,X562 0
4JDKA 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 F461V X474,X562 0
4FIHA 1.97 Active DFGin BLAminus in-in in-in No_ligand No_ligand 298 - 589 None X474 0
4FIIA 2.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 299 - 590 None X474 0
4FIJA 2.3 Active DFGin BLAminus in-in in-in No_ligand No_ligand 299 - 590 None X474 0
4JDHA 2.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 None X474 0
6WLXA 2.2 Active DFGin BLAminus in-in in-in No_ligand No_ligand 299 - 590 None X474 0
6WLYA 1.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 299 - 590 None X474 0
7S48A 1.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 None X474 0
5UPLA 3.003 Active DFGin BLAminus in-in in-in No_ligand No_ligand 299 - 589 None X474 0
5XVFA 2.655 Active DFGin BLAminus in-in in-in 8FR Type1 300 - 588 None X474 0
5XVAA 1.847 Active DFGin BLAminus in-in in-in 8FU Type1 300 - 591 None X474 0
5XVGA 2.1 Active DFGin BLAminus in-in in-in 8FX Type1 300 - 591 None X474 0
5ZJWA 1.798 Active DFGin BLAminus in-in in-in 9EO Type1 300 - 591 None X474 0
5BMSA 2.903 Active DFGin BLAminus in-in in-in 4T6 Type1 300 - 589 None X474 0
2X4ZA 2.1 Active DFGin BLAminus out-in in-in 7KC Type1 299 - 590 P296G,Q297S,R298H,V299M X474 0
4APPA 2.2 Active DFGin BLAminus out-in in-in N53 Type1 300 - 591 None X474 0
4NJDA 2.5 Active DFGin BLAminus in-in in-in NJD Type1 300 - 589 None X474 0
5I0BA 3.09 Active DFGin BLAminus in-in in-in 67U Type1 301 - 589 None X474 0
8AHGA 1.885 Active DFGin BLAminus in-in in-in M4I Type1 300 - 591 L310A X474 0
8AHHA 2.037 Active DFGin BLAminus in-in in-in M4X Type1 300 - 591 L310A X474 0
8AHIA 2.69 Inactive DFGin BLAminus in-out in-in M56 Type1 300 - 591 L310A X474 0
2CDZA 2.3 Active DFGin BLAminus in-in in-in 23D Type1 299 - 590 None X474 0
5VEDA 2.301 Inactive DFGin BLAminus in-out in-in STU Type1 300 - 589 None X474 0
5VEEA 2.5 Inactive DFGin BLAminus in-out in-in 981 Type1 300 - 589 None X474 0
5VEFA 1.752 Active DFGin BLAminus in-in in-in M77 Type1 300 - 589 None X474 0
4FIFA 2.6 Active DFGin BLAminus in-in in-in ANP Type1 296 - 589 None X474 0
4FIFB 2.6 Active DFGin BLAminus in-in in-in ANP Type1 297 - 589 None X474 0
4FIGA 3.01 Active DFGin BLAminus in-in in-in ANP Type1 298 - 590 None X474 0
4JDIA 1.85 Active DFGin BLAminus in-in in-in ANP Type1 300 - 589 None X474 0
5UPKB 2.4 Active DFGin BLAminus in-in in-in ANP Type1 300 - 588 None X474 0
4FIEA 3.11 Inactive DFGin BLAminus in-out in-in ANP Type1 49 - 590 None X474 0
4FIEB 3.11 Inactive DFGin BLAminus in-out in-in ANP Type1 49 - 590 None X474 0
7S46A 2.1 Active DFGin BLAminus in-in in-in ANP Type1 300 - 589 D440N,S474E None 0
7S47A 2.0 Active DFGin BLAminus in-in in-in ANP Type1 300 - 589 D440N,S474E None 0
7CP3A 2.9 Active DFGin BLAminus in-in in-in GC6 Type1.5_Back 300 - 589 None X474 0
7CP4A 2.5 Active DFGin BLAminus in-in in-in GCC Type1.5_Back 300 - 591 None X474 0
7CMBA 2.592 Active DFGin BLAminus in-in in-in G5X Type1.5_Back 300 - 589 None X474 0
4O0VA 2.8 Active DFGin BLAminus in-in in-in 2OL Type1.5_Back 300 - 589 None X474 0
4O0XA 2.483 Active DFGin BLAminus in-in in-in 2OQ Type1.5_Back 300 - 589 None X474 0
4O0YA 2.2 Active DFGin BLAminus in-in in-in 2OO Type1.5_Back 300 - 589 None X474 0
4FIGB 3.01 Inactive DFGin None in-in in-in ANP Type1 298 - 590 None X474 0

PAK4 (Serine/threonine-protein kinase PAK 4)

Group: STE
Total number of chains: 51
Spatial Dihedral Chains Representative
DFGin BLAminus 49 AF-O96013-K1A
DFGin ABAminus 1 4XBRA
DFGin None 1 4FIGB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens PAK4_HUMAN 4XBRA 2.94 Inactive DFGin ABAminus in-in in-in ATP Type1 177 - 589 None X474 0
Homo sapiens PAK4_HUMAN AF-O96013-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 313 - 580 None None 0
Homo sapiens PAK4_HUMAN 2BVAA 2.3 Inactive DFGin BLAminus out-out out-in No_ligand No_ligand 300 - 587 None X474 2
Homo sapiens PAK4_HUMAN 2BVAB 2.3 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 301 - 587 None X474 2
Homo sapiens PAK4_HUMAN 4L67A 2.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 2Q0NA 1.75 Active DFGin BLAminus in-in in-in No_ligand No_ligand 298 - 591 None X474 0
Homo sapiens PAK4_HUMAN 8YHKA 3.3 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 298 - 591 None None 0
Homo sapiens PAK4_HUMAN 2J0IA 1.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 4XBUA 2.06 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 297 - 589 None X474 0
Homo sapiens PAK4_HUMAN 4JDJA 2.3 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 F461V X474,X562 0
Homo sapiens PAK4_HUMAN 4JDKA 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 F461V X474,X562 0
Homo sapiens PAK4_HUMAN 4FIHA 1.97 Active DFGin BLAminus in-in in-in No_ligand No_ligand 298 - 589 None X474 0
Homo sapiens PAK4_HUMAN 4FIIA 2.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 299 - 590 None X474 0
Homo sapiens PAK4_HUMAN 4FIJA 2.3 Active DFGin BLAminus in-in in-in No_ligand No_ligand 299 - 590 None X474 0
Homo sapiens PAK4_HUMAN 4JDHA 2.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 6WLXA 2.2 Active DFGin BLAminus in-in in-in No_ligand No_ligand 299 - 590 None X474 0
Homo sapiens PAK4_HUMAN 6WLYA 1.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 299 - 590 None X474 0
Homo sapiens PAK4_HUMAN 7S48A 1.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 5UPLA 3.003 Active DFGin BLAminus in-in in-in No_ligand No_ligand 299 - 589 None X474 0
Homo sapiens PAK4_HUMAN 5XVFA 2.655 Active DFGin BLAminus in-in in-in 8FR Type1 300 - 588 None X474 0
Homo sapiens PAK4_HUMAN 5XVAA 1.847 Active DFGin BLAminus in-in in-in 8FU Type1 300 - 591 None X474 0
Homo sapiens PAK4_HUMAN 5XVGA 2.1 Active DFGin BLAminus in-in in-in 8FX Type1 300 - 591 None X474 0
Homo sapiens PAK4_HUMAN 5ZJWA 1.798 Active DFGin BLAminus in-in in-in 9EO Type1 300 - 591 None X474 0
Homo sapiens PAK4_HUMAN 5BMSA 2.903 Active DFGin BLAminus in-in in-in 4T6 Type1 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 2X4ZA 2.1 Active DFGin BLAminus out-in in-in 7KC Type1 299 - 590 P296G,Q297S,R298H,V299M X474 0
Homo sapiens PAK4_HUMAN 4APPA 2.2 Active DFGin BLAminus out-in in-in N53 Type1 300 - 591 None X474 0
Homo sapiens PAK4_HUMAN 4NJDA 2.5 Active DFGin BLAminus in-in in-in NJD Type1 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 5I0BA 3.09 Active DFGin BLAminus in-in in-in 67U Type1 301 - 589 None X474 0
Homo sapiens PAK4_HUMAN 8AHGA 1.885 Active DFGin BLAminus in-in in-in M4I Type1 300 - 591 L310A X474 0
Homo sapiens PAK4_HUMAN 8AHHA 2.037 Active DFGin BLAminus in-in in-in M4X Type1 300 - 591 L310A X474 0
Homo sapiens PAK4_HUMAN 8AHIA 2.69 Inactive DFGin BLAminus in-out in-in M56 Type1 300 - 591 L310A X474 0
Homo sapiens PAK4_HUMAN 2CDZA 2.3 Active DFGin BLAminus in-in in-in 23D Type1 299 - 590 None X474 0
Homo sapiens PAK4_HUMAN 5VEDA 2.301 Inactive DFGin BLAminus in-out in-in STU Type1 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 5VEEA 2.5 Inactive DFGin BLAminus in-out in-in 981 Type1 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 5VEFA 1.752 Active DFGin BLAminus in-in in-in M77 Type1 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 4FIFA 2.6 Active DFGin BLAminus in-in in-in ANP Type1 296 - 589 None X474 0
Homo sapiens PAK4_HUMAN 4FIFB 2.6 Active DFGin BLAminus in-in in-in ANP Type1 297 - 589 None X474 0
Homo sapiens PAK4_HUMAN 4FIGA 3.01 Active DFGin BLAminus in-in in-in ANP Type1 298 - 590 None X474 0
Homo sapiens PAK4_HUMAN 4JDIA 1.85 Active DFGin BLAminus in-in in-in ANP Type1 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 5UPKB 2.4 Active DFGin BLAminus in-in in-in ANP Type1 300 - 588 None X474 0
Homo sapiens PAK4_HUMAN 4FIEA 3.11 Inactive DFGin BLAminus in-out in-in ANP Type1 49 - 590 None X474 0
Homo sapiens PAK4_HUMAN 4FIEB 3.11 Inactive DFGin BLAminus in-out in-in ANP Type1 49 - 590 None X474 0
Homo sapiens PAK4_HUMAN 7S46A 2.1 Active DFGin BLAminus in-in in-in ANP Type1 300 - 589 D440N,S474E None 0
Homo sapiens PAK4_HUMAN 7S47A 2.0 Active DFGin BLAminus in-in in-in ANP Type1 300 - 589 D440N,S474E None 0
Homo sapiens PAK4_HUMAN 7CP3A 2.9 Active DFGin BLAminus in-in in-in GC6 Type1.5_Back 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 7CP4A 2.5 Active DFGin BLAminus in-in in-in GCC Type1.5_Back 300 - 591 None X474 0
Homo sapiens PAK4_HUMAN 7CMBA 2.592 Active DFGin BLAminus in-in in-in G5X Type1.5_Back 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 4O0VA 2.8 Active DFGin BLAminus in-in in-in 2OL Type1.5_Back 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 4O0XA 2.483 Active DFGin BLAminus in-in in-in 2OQ Type1.5_Back 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 4O0YA 2.2 Active DFGin BLAminus in-in in-in 2OO Type1.5_Back 300 - 589 None X474 0
Homo sapiens PAK4_HUMAN 4FIGB 3.01 Inactive DFGin None in-in in-in ANP Type1 298 - 590 None X474 0

PAK4 (Serine/threonine-protein kinase PAK 4)

No non-human structures known.