MAP3K12 (Mitogen-activated protein kinase kinase kinase 12)

Group: TKL
Uniprot: M3K12_HUMAN
Domain boundary: 125 - 366


Total number of chains: 11
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q12852-K1A
DFGin BLBminus 1 5CENA
DFGin BLBplus 9 5CEQA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q12852-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 117 - 374 None None 0
5CENA 1.7 Inactive DFGin BLBminus out-out out-out No_ligand No_ligand 117 - 397 None None 0
5CEOA 2.28 Inactive DFGin BLBplus out-out none-out 50D Type1 117 - 398 None None 13
5CEPA 1.99 Inactive DFGin BLBplus out-out none-out 50E Type1 117 - 398 None None 13
5CEQA 1.911 Inactive DFGin BLBplus out-out none-out 50F Type1 117 - 398 None None 13
5VO1A 2.45 Inactive DFGin BLBplus out-out none-out 9FS Type1 117 - 398 None None 13
5VO2A 2.96 Inactive DFGin BLBplus out-out none-out 9FV Type1 117 - 398 None None 13
8OURA 1.95 Inactive DFGin BLBplus out-out none-out W38 Type1 118 - 396 None None 15
8OUSA 2.2 Inactive DFGin BLBplus out-out none-out W3I Type1 118 - 397 None None 15
8OUTA 1.935 Inactive DFGin BLBplus out-out none-out W3C Type1 118 - 399 None None 15
8DEGA 2.79 Inactive DFGin BLBplus out-out none-out SIQ Type1 117 - 398 None None 15

MAP3K12 (Mitogen-activated protein kinase kinase kinase 12)

Group: TKL
Total number of chains: 11
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-Q12852-K1A
DFGin BLBminus 1 5CENA
DFGin BLBplus 9 5CEQA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens M3K12_HUMAN AF-Q12852-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 117 - 374 None None 0
Homo sapiens M3K12_HUMAN 5CENA 1.7 Inactive DFGin BLBminus out-out out-out No_ligand No_ligand 117 - 397 None None 0
Homo sapiens M3K12_HUMAN 5CEOA 2.28 Inactive DFGin BLBplus out-out none-out 50D Type1 117 - 398 None None 13
Homo sapiens M3K12_HUMAN 5CEPA 1.99 Inactive DFGin BLBplus out-out none-out 50E Type1 117 - 398 None None 13
Homo sapiens M3K12_HUMAN 5CEQA 1.911 Inactive DFGin BLBplus out-out none-out 50F Type1 117 - 398 None None 13
Homo sapiens M3K12_HUMAN 5VO1A 2.45 Inactive DFGin BLBplus out-out none-out 9FS Type1 117 - 398 None None 13
Homo sapiens M3K12_HUMAN 5VO2A 2.96 Inactive DFGin BLBplus out-out none-out 9FV Type1 117 - 398 None None 13
Homo sapiens M3K12_HUMAN 8OURA 1.95 Inactive DFGin BLBplus out-out none-out W38 Type1 118 - 396 None None 15
Homo sapiens M3K12_HUMAN 8OUSA 2.2 Inactive DFGin BLBplus out-out none-out W3I Type1 118 - 397 None None 15
Homo sapiens M3K12_HUMAN 8OUTA 1.935 Inactive DFGin BLBplus out-out none-out W3C Type1 118 - 399 None None 15
Homo sapiens M3K12_HUMAN 8DEGA 2.79 Inactive DFGin BLBplus out-out none-out SIQ Type1 117 - 398 None None 15

MAP3K12 (Mitogen-activated protein kinase kinase kinase 12)

No non-human structures known.