2Z8C

INSR (Insulin receptor)
Group: TYR
Uniprot: INSR_HUMAN
Organism: Homo sapiens
Domain boundary: 1023 - 1292
Resolu: 3.25

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-out in-in S91 Type1 1011 - 1310 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
      1017       1027       1037       1047 
ssvFVPDEWE VSREKITLLR ELGQGSFGMV YEGNARDIIK 
      1057       1067       1077       1087 
GEAETRVAVK TVNESASLRE RIEFLNEASV MKGFTCHHVV 
      1097       1107       1117       1127 
RLLGVVSKGQ PTLVVMELMA HGDLKSYLRS LRPEAENNPG 
      1137       1147       1157       1167 
RPPPTLQEMI QMAAEIADGM AYLNAKKFVH RDLAARNCMV 
      1177       1187       1197       1207 
AHDFTVKIGD FGMTRDIYET DYYRKGGKGL LPVRWMAPES 
      1217       1227       1237       1247 
LKDGVFTTSS DMWSFGVVLW EITSLAEQPY QGLSNEQVLK 
      1257       1267       1277       1287 
FVMDGGYLDQ PDNCPERVTD LMRMCWQFNP KMRPTFLEIV 
      1297       1307 
NLLKDDLHPS FPEVSFFHSE ENK
Lower-case residues are disordered in structure.
Mutations: C1008S,Y1011F
Phosphorylation: X1185,X1189,X1190